Cross-Domain Generalization

Federated domain generalization for person re-identification (FedDG-ReID) aims to collaboratively train a pedestrian retrieval model across multiple decentralized source domains such that it can generalize to unseen target environments without compromising raw data privacy. However, this task is significantly challenged by the inherent stylistic gaps across decentralized clients. Without global supervision, models easily succumb to shortcut learning where representations overfit to domain specific camera biases rather than universal identity features. We propose CO-EVO, a novel federated framework that resolves this semantic-style conflict through a co-evolutionary mechanism. On the semantic side, Camera-Invariant Semantic Anchoring (CSA) learns identity prompts with cross-camera consistency to establish purified and domain-agnostic anchors that filter out local imaging noise. On the visual side, Global Style Diversification (GSD), powered by a Global Camera-Style Bank (GCSB), synthesizes realistic perturbations to expand the visual boundaries of training data. The core of CO-EVO is its co-evolutionary loop where purified anchors act as gravitational centers to guide the image encoder toward robust anatomical attributes amidst diverse style variations. Extensive experiments demonstrate that CO-EVO achieves state-of-the-art (SOTA) performance, proving that the synergy between semantic purification and style expansion is essential for robust cross-domain generalization. Our code is available at: https://github.com/NanYiyuzurn/ACL-LGPS-2026.

Magnification shift is a major obstacle to robust histopathology classification, because models trained on one imaging scale often generalize poorly to another. Here, we evaluated this problem on the BreaKHis dataset using a strict patient-disjoint leave-one-magnification-out protocol, comparing supervised baseline, baseline augmented with DCGAN-generated patches, and a gradient-reversal domain-general model designed to preserve discriminative information while suppressing magnification-specific variation. Across held-out magnifications, the domain-general model achieved the strongest overall discrimination and its clearest gain was observed when 200X was held out. By contrast, GAN augmentation produced inconsistent effects, improving some folds but degrading others, particularly at 400X. The domain-general model also yielded the lowest Brier score at 0.063 vs 0.089 at baseline. Sparse embedding analysis further revealed that domain-general training reduced average signature size more than three-fold (306 versus 1,074 dimensions) while preserving equivalent predictive performance (AUC: 0.967 vs 0.965; F1: 0.930 vs 0.931). It also increased cross-fold signature reproducibility from near-zero Jaccard overlap in the baseline to 0.99 between the 100X and 200X folds. These findings show that calibrated, compact, and transferable representations can be learned without added architectural complexity, with clear implications for the reliable deployment of computational pathology models across heterogeneous acquisition settings.

Accurate predictions of smallholder maize yields across national boundaries are critical for food security planning in sub-Saharan Africa, yet most published benchmarks report within-country performance that overstates true generalisability. This paper evaluates whether geospatial foundation model embeddings, specifically Prithvi-EO-1.0-100M and ViT-Base, outperform traditional Sentinel-2 spectral features under a Leave-One-Country-Out cross-validation scheme on 6,404 maize field observations from five African countries. The results show a clear generalisability gap: within-country random cross-validation yields moderate R^2 values, but all feature sets perform poorly under cross-country testing, with universally negative R^2. Frozen Prithvi-EO embeddings provide no meaningful advantage over engineered spectral features for cross-country prediction in this setting. The paper argues that the main limitation is a shift in yield distribution between countries rather than representation quality and releases a reproducible negative benchmark for future work.

Real-world weather, illumination, and imaging variations often induce severe domain shifts, degrading single-source detectors in unseen environments. Existing single-domain generalized object detection (SDGOD) methods mainly rely on data augmentation or domain-invariant learning, while largely overlooking how domain shift disrupts detector prediction stability. Through analytical experiments, we find that performance degradation is mainly dominated by increasing missed detections. Further analysis shows that this phenomenon stems from reduced cross-domain stability in DETR-style detectors: domain shift disrupts encoder-side object-background and inter-instance relations, and further weakens the semantic-spatial binding between decoder queries and real objects. Motivated by this, we find that vision foundation models (VFMs) still preserve stable relational structures and object responses under severe shifts, making them suitable cross-domain stability priors to compensate for detector degradation. To this end, we propose VFM$^{4}$SDG, a dual-prior learning framework for SDGOD, which introduces a frozen VFM into encoder representation learning and decoder query modeling. Specifically, we propose Cross-domain Stable Relational Prior Distillation to distill stable object-background and inter-instance relations from the VFM into the encoder, compensating for relational degradation. Meanwhile, we propose Semantic-Contextual Prior-based Query Enhancement, which injects category semantic prototypes and global object context into queries before they enter the decoder layer, enhancing semantic-spatial query-object binding stability. Extensive experiments show that VFM$^{4}$SDG significantly outperforms existing advanced methods on standard SDGOD benchmarks and two mainstream DETR-based detection frameworks, demonstrating its effectiveness, robustness, and generality.

Fault diagnosis under unseen operating conditions remains highly challenging when labeled data are scarce. Semi-supervised domain generalization fault diagnosis (SSDGFD) provides a practical solution by jointly exploiting labeled and unlabeled source domains. However, existing methods still suffer from two coupled limitations. First, pseudo-labels for unlabeled domains are typically generated primarily from knowledge learned on the labeled source domain, which neglects domain-specific geometric discrepancies and thus induces systematic cross-domain pseudo-label bias. Second, unlabeled samples are commonly handled with a hard accept-or-discard strategy, where rigid thresholding causes imbalanced sample utilization across domains, while hard-label assignment for uncertain samples can easily introduce additional noise. To address these issues, we propose a unified framework termed domain-aware hierarchical contrastive learning (DAHCL) for SSDGFD. Specifically, DAHCL introduces a domain-aware learning (DAL) module to explicitly capture source-domain geometric characteristics and calibrate pseudo-label predictions across heterogeneous source domains, thereby mitigating cross-domain bias in pseudo-label generation. In addition, DAHCL develops a hierarchical contrastive learning (HCL) module that combines dynamic confidence stratification with fuzzy contrastive supervision, enabling uncertain samples to contribute to representation learning without relying on unreliable hard labels. In this way, DAHCL jointly improves the quality of supervision and the utilization of unlabeled samples. Furthermore, to better reflect practical industrial scenarios, we incorporate engineering noise into the SSDGFD evaluation protocol. Extensive experiments on three benchmark datasets demonstrate that...

Automated bacterial colony counting from images is an important technique to obtain data required for the development of vaccines and antibiotics. However, bacterial colonies present unique machine vision challenges that affect counting, including (1) small physical size, (2) object clustering, (3) high data annotation cost, and (4) limited cross-species generalisation. While FamNet is an established object counting technique effective for clustered objects and costly data annotation, its effectiveness for small colony sizes and cross-species generalisation remains unknown. To address the first three challenges, we propose ACFamNet, an extension of FamNet that handles small and clustered objects using a novel region of interest pooling with alignment and optimised feature engineering. To address all four challenges above, we introduce ACFamNet Pro, which augments ACFamNet with multi-head attention and residual connections, enabling dynamic weighting of objects and improved gradient flow. Experiments show that ACFamNet Pro achieves a mean normalised absolute error (MNAE) of 9.64% under 5-fold cross-validation, outperforming ACFamNet and FamNet by 2.23% and 12.71%, respectively.

Pretrained biomedical vision-language models (VLMs) such as BioMedCLIP perform well on average but often degrade on challenging modalities where inter-class margins are small and acquisition-specific variations are pronounced, especially under few-shot supervision and when modality priors differ from pretraining corpora substantially. We propose BioVLM, a prompt-learning framework that improves cross-domain generalization without extensive backbone fine-tuning. BioVLM learns a diverse prompt bank and introduces dynamic prompt selection: for each input, it selects the most discriminative prompts via a low-entropy criterion on the predictive distribution, effectively coupling sparse few-shot evidence with rich LLM semantic priors. To strengthen this coupling, we distill high-confidence LLM-derived attributes and enforce robust knowledge transfer through strong/weak augmentation consistency. At test time, BioVLM adapts by choosing modality-appropriate prompts, enabling transfer to unseen categories and domains, while keeping training lightweight and inference efficient. On 11 MedMNIST+ 2D datasets, BioVLM achieves new state of the art across three distinct generalization settings. Codes are available at https://github.com/mainaksingha01/BioVLM.

Domain generalization (DG) aims to maintain performance under domain shift, which in computer vision appears primarily as stylistic variations that cause models to overfit to domain-specific appearance cues rather than class semantics. To overcome this, recent methods use textual representations as stable, domain-invariant anchors. However, multimodal approaches that rely on cosine similarity-based contrastive alignment leave a modality gap where image and text embeddings remain geometrically separated despite semantic correspondence. We propose CrossFlowDG, a novel DG framework that addresses this residual gap using noise-free, cross-modal flow matching. By learning a continuous transformation in the joint Euclidean latent space, our framework explicitly transports domain-biased image embeddings toward domain-invariant text embeddings of the correct class. Using the efficient VMamba image encoder and CLIP's text encoder, CrossFlowDG is tested against four common DG benchmarks, and achieves competitive performance on several benchmarks and state-of-the-art on TerraIncognita. Code is available at: https://github.com/ajkrit/CrossFlowDG

With the rapid development of generative models and multimodal content editing technologies, the key challenge faced by synthetic image detection (SID) lies in cross-distribution generalization to unknown generation sources. In recent years, visual foundation models (VFM), which acquire rich visual priors through large scale image-text alignment pretraining, have become a promising technical route for improving the generalization ability of SID. However, existing VFM-based methods remain relatively coarse-grained in their adaptation strategies. They typically either directly use the final layer representations of VFM or simply fuse multi layer features, lacking explicit modeling of the optimal representational hierarchy for transferable forgery cues. Meanwhile, although directly fine-tuning VFM can enhance task adaptation, it may also damage the cross-modal pretrained structure that supports open-set generalization. To address this task specific tension, we reformulate VFM adaptation for SID as a joint optimization problem: it is necessary both to identify the critical representational layer that is more suitable for carrying forgery discriminative information and to constrain the disturbance caused by task knowledge injection to the pretrained structure. Based on this, we propose I2P, an SID framework centered on intrinsic importance perception. I2P first adaptively identifies the critical layer representations that are most discriminative for SID, and then constrains task-driven parameter updates within a low sensitivity parameter subspace, thereby improving task specificity while preserving the transferable structure of pretrained representations as much as possible.

Generalizable gaze estimation methods have garnered increasing attention due to their critical importance in real-world applications and have achieved significant progress. However, they often overlook the effect of label noise, arising from the inherent difficulty of acquiring precise gaze annotations, on model generalization performance. In this paper, we are the first to comprehensively investigate the negative effects of label noise on generalization in gaze estimation. Further, we propose a novel solution, called See-Through-Noise (SeeTN) framework, which improves generalization from a novel perspective of mitigating label noise. Specifically, we propose to construct a semantic embedding space via a prototype-based transformation to preserve a consistent topological structure between gaze features and continuous labels. We then measure feature-label affinity consistency to distinguish noisy from clean samples, and introduce a novel affinity regularization in the semantic manifold to transfer gaze-related information from clean to noisy samples. Our proposed SeeTN promotes semantic structure alignment and enforces domain-invariant gaze relationships, thereby enhancing robustness against label noise. Extensive experiments demonstrate that our SeeTN effectively mitigates the adverse impact of source-domain noise, leading to superior cross-domain generalization without compromising the source-domain accuracy, and highlight the importance of explicitly handling noise in generalized gaze estimation.

Multimodal deception detection aims to identify deceptive behavior by analyzing audiovisual cues for forensics and security. In these high-stakes settings, investigators need verifiable evidence connecting audiovisual cues to final decisions, along with reliable generalization across domains and cultural contexts. However, existing benchmarks provide only binary labels without intermediate reasoning cues. Datasets are also small with limited scenario coverage, leading to shortcut learning. We address these issues through three contributions. First, we construct reasoning datasets by augmenting existing benchmarks with structured cue-level descriptions and reasoning chains, enabling models to output auditable reports. Second, we release T4-Deception, a multicultural dataset based on the unified ``To Tell the Truth'' television format implemented across four countries. With 1695 samples, it is the largest non-laboratory deception detection dataset. Third, we propose two modules for robust learning under small-data conditions. Stabilized Individuality-Commonality Synergy (SICS) refines multimodal representations by combining learnable global priors with sample-adaptive residuals and applying polarity-aware recalibration. Distilled Modality Consistency (DMC) aligns modality-specific predictions with the fused multimodal predictions via knowledge distillation to prevent unimodal shortcut learning. Experiments on three established benchmarks and our novel dataset demonstrate that our method achieves state-of-the-art performance in both in-domain and cross-domain scenarios, while exhibiting superior transferability across diverse cultural contexts. The datasets and code are available at this link.

We propose a novel swap-adversarial framework that mitigates high inter-subject variability and the high-dimensional low-sample-size problem in electrocorticography (ECoG) data. It achieves robust domain generalization across ECoG and electroencephalography (EEG)-based brain-computer interface datasets. Our framework integrates (1) robust preprocessing, (2) inter-subject balanced channel swap (ISBCS) for cross-subject augmentation, and (3) domain-adversarial learning (DAL) to suppress subject-specific bias. The ISBCS method is a bio-inspired channel swapping strategy that exchanges only functionally corresponding channels across subjects, guided by a brain map, to mitigate inter-subject distribution differences. The DAL strategy encourages the model to learn task-relevant shared features. We validate the effectiveness of this framework through extensive experiments under cross-subject, cross-session, and cross-dataset settings. Our framework consistently outperforms all baselines across all settings, showing the most significant improvements in highly variable environments. It also achieves superior cross-dataset performance between public EEG benchmarks, demonstrating strong generalization capability not only for ECoG but also for EEG data. In addition, we introduce a new ECoG dataset, the first reproducible benchmark, which is constructed from long-term ECoG recordings of 6-hydroxydopamine-induced rat models and annotated with neural responses measured before and after electrical stimulation.

LiDAR scene flow is the task of estimating per-point 3D motion between consecutive point clouds. Recent methods achieve centimeter-level accuracy on popular autonomous vehicle (AV) datasets, but are typically only trained and evaluated on a single sensor. In this paper, we aim to learn general motion priors that transfer to diverse and unseen LiDAR sensors. However, prior work in LiDAR semantic segmentation and 3D object detection demonstrate that naively training on multiple datasets yields worse performance than single dataset models. Interestingly, we find that this conventional wisdom does not hold for motion estimation, and that state-of-the-art scene flow methods greatly benefit from cross-dataset training without architectural modification. We posit that low-level tasks such as motion estimation may be less sensitive to sensor configuration; indeed, our analysis shows that models trained on fast-moving objects (e.g., from highway datasets) perform well on fast-moving objects, even across different datasets. Informed by our analysis, we propose UniFlow, a feedforward model that unifies and trains on multiple large-scale LiDAR scene flow datasets with diverse sensor placements and point cloud densities. Our frustratingly simple solution establishes a new state-of-the-art on Waymo and nuScenes, improving over prior work by 5.1% and 35.2% respectively. Moreover, UniFlow achieves state-of-the-art accuracy on unseen datasets like TruckScenes and AEVAScenes, outperforming prior dataset-specific models by 30.1% and 22.5% respectively.

Domain generalization (DG) aims to improve the generalizability of computer vision models toward distribution shifts. The mainstream DG methods predominantly focus on learning domain invariance across domains, however, such methods overlook the untapped potential inherent in domain-specific information. While the prevailing practice of discriminative linear classifier has been tailored to domain-invariant features, it struggles when confronted with diverse domain-specific information, \emph{e.g.,} intra-class shifts, that exhibits multi-modality. To address these issues, we explore the theoretical implications of relying on domain-invariant features, revealing the crucial role of domain-specific information in mitigating the target risk for DG. Drawing from these insights, we propose Generative Classifier-driven Domain Generalization (GCDG), introducing a generative paradigm for the DG classifier based on Gaussian Mixture Models (GMMs) for each class across domains. GCDG consists of three key modules: Heterogeneity Learning Classifier~(HLC), Spurious Correlation Blocking~(SCB), and Diverse Component Balancing~(DCB). Concretely, HLC attempts to model the feature distributions and thereby capture valuable domain-specific information via GMMs. SCB identifies the neural units containing spurious correlations and perturbs them, mitigating the risk of HLC learning irrelevant spurious patterns. Meanwhile, DCB ensures a balanced contribution of components within HLC, preventing the underestimation or neglect of critical components. In this way, GCDG excels in capturing the nuances of domain-specific information characterized by diverse distributions. Extensive experiments show GCDG's comparable performance on five DG benchmarks and one face anti-spoofing dataset, seamlessly integrating into existing DG methods with consistent improvements.

Deploying deep learning-based imaging tools across various clinical sites poses significant challenges due to inherent domain shifts and regulatory hurdles associated with site-specific fine-tuning. For histopathology, stain normalization techniques can mitigate discrepancies, but they often fall short of eliminating inter-site variations. Therefore, we present Data Alchemy, an explainable stain normalization method combined with test time data calibration via a template learning framework to overcome barriers in cross-site analysis. Data Alchemy handles shifts inherent to multi-site data and minimizes them without needing to change the weights of the normalization or classifier networks. Our approach extends to unseen sites in various clinical settings where data domain discrepancies are unknown. Extensive experiments highlight the efficacy of our framework in tumor classification in hematoxylin and eosin-stained patches. Our explainable normalization method boosts classification tasks' area under the precision-recall curve(AUPR) by 0.165, 0.545 to 0.710. Additionally, Data Alchemy further reduces the multisite classification domain gap, by improving the 0.710 AUPR an additional 0.142, elevating classification performance further to 0.852, from 0.545. Our Data Alchemy framework can popularize precision medicine with minimal operational overhead by allowing for the seamless integration of pre-trained deep learning-based clinical tools across multiple sites.

Inspired by the impressive success of image-text foundation models, recent works have proposed to adapt these foundation models to video data, leading to efficient and effective video models for open-vocabulary action recognition. However, through a comprehensive evaluation, our work finds that state-of-the-art open-vocabulary action recognition models still struggle with generalization to video domains that they have not encountered. To address this limitation, we introduce \textit{generalizable open-vocabulary action recognition}, which aims to develop action recognition models capable of generalizing to both novel action categories and unseen video domains. Our work contributes a novel model named XOV-Action to overcome two critical challenges: (1) understanding novel action concepts of open-set categories, and (2) mitigating the scenario discrepancy between training and test datasets. Specifically, XOV-Action first proposes to capture diverse action-related concepts by learning diversified elaboration representations, which enables better generalization to open-set action categories. Second, XOV-Action learns scene-agnostic video representations to overcome the scene bias, which improves the generalization in unseen video domains. Additionally, to evaluate models in generalizable open-vocabulary action recognition, we contribute a new cross-domain action benchmark named XOVABench, which covers multiple video domains with varying degrees of gaps and consists of both closed-set and open-set action categories. Extensive quantitative and qualitative experiments demonstrate that our proposed XOV-Action can effectively improve action recognition performance for both closed-set and open-set categories across video domains. The benchmark is available at https://github.com/KunyuLin/XOV-Action/.

Building trustworthy machine learning algorithms for biological applications requires adapting to data heterogeneity from different sources, batches, distributions, or studies. We propose the 'Cross-Cluster Weighted Forest' (CCWF), an ensembling approach that explicitly leverages heterogeneity in the feature distribution to produce more accurate and more generalizable predictors than the standard Random Forest in cases when data can be naturally clustered. CCWF generalizes the RF architecture to an outer unsupervised layer, supervised subtasks, and ensembling. Specifically it involves unsupervised clustering of the training data, fitting a Random Forest on each cluster, and combining the forests via stacked regression weights that reward cross-cluster generalizability. We provide a theoretical analysis of an analytically tractable forest model showing that cluster-based ensembling is asymptotically more accurate than training a single forest on the full data, with the gain driven by bias reduction. In simulations, we find that CCWF is robust across data-generating regimes and outcome models; furthermore, we explore the influence of data partitioning and ensemble weighting strategies on the benefits of our method. Finally, we apply our approach to cancer molecular profiling and gene expression datasets that are naturally divisible into clusters; in both simulations and real data examples, we illustrate that our approach outperforms classic Random Forest by margins of 30-40%, aligning with our theoretical results. Overall, we show that CCWF provides a statistically grounded prediction algorithm for data spanning multiple domains or sub-populations, a structure common in biological applications.

This paper studies continual test-time adaptation (CTTA), the task of adapting a model to constantly changing unseen domains in testing while preserving previously learned knowledge. Existing CTTA methods mostly focus on adaptation to the current test domain only, overlooking generalization to arbitrary test domains a model may face in the future. To tackle this limitation, we present a novel online test-time domain generalization framework for CTTA, dubbed TestDG. TestDG aims to learn features invariant to both current and previous test domains on the fly during testing, improving the potential for effective generalization to future domains. To this end, we propose a new model architecture and a test-time adaptation strategy dedicated to learning domain-invariant features, along with prototype selection and update mechanisms for effectively managing information from previous test domains. TestDG achieved state of the art on four public CTTA benchmarks. Moreover, it showed superior generalization to unseen test domains.