Cancer Genomics

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Overview

Cancer genomics studies how mutations, gene expression, copy-number changes, and other molecular features shape tumor development, patient outcomes, and treatment response. Common approaches include statistical driver and mutation-signature analysis, multi-omics integration, and pathway or regulatory-network models, alongside machine learning on sequencing, pathology images, and scans. Researchers evaluate these methods on resources such as TCGA and clinical cohorts, with tasks including subtype classification, survival prediction, biomarker discovery, and drug response. A central challenge is making predictions that generalize across cancers and incomplete datasets while remaining biologically interpretable and reliable enough for clinical use.

Latest papers

CardsList

34 papers1 paper in the last four weeks, down 75% on the four weeks before. 0.0% of all new papers.

  1. Tensor-based Fusion of Multi-modal Data for Predicting Cancer Risk Levels

    Oct 9, 2026Ali Anaissi, Yuanzhe Jia, Qishun Peng +3Clinical Risk PredictionMultimodal Fusion

    University of Sydney, Australia · University of Technology Sydney, Australia · University of New South Wales, Australia

  2. Semi-Supervised Learning-Based Genetic Biomarkers Dataset for Multiple-Stage Hepatocellular Carcinoma Prediction

    Sep 15, 2026Ahmed Ammar Kubba, Manar Abu Talib, Jibran Sualeh Muhammad +4Cancer GenomicsGenomics

    Department of Computer Science, University of Sharjah, Sharjah, UAE · Department of Biomedical Sciences, University of Birmingham, Birmingham, United Kingdom · Department of Computer Engineering, University of Sharjah, Sharjah, UAE +1

  3. Democratizing Clinical Tumor Whole Genome Sequencing: 18-hour End-to-end Analysis via Trillion-parameter Large Language Models Locally Deployed on Consumer-grade Hardware

    Sep 14, 2026Rui Xiao, Yili XuGenomicsCancer Genomics

    Hangzhou Tsingxin quantum Co., Ltd.

  4. Potential of Artificial Intelligence Algorithms for Identification of Relevant Diagnostic and Prognostic Biomarkers of Early-Stage Liver Cancer

    Sep 14, 2026Ali Bou Nassif, Darko Castven, Manar Abu Talib +4Cancer GenomicsMedical Diagnosis

    Department of Computer Engineering, College of Computing and Informatics University of Sharjah, Sharjah, United Arab Emirates · Department of Medicine I, University Medical Center Schleswig-Holstein, University of Lubeck, Lübeck, Germany · Department of Computer Science, College of Computing and Informatics University of Sharjah, Sharjah, United Arab Emirates +1

  5. Responsible Integration of AI in Cancer Genomics: Barriers, Risks, and Pathways to Trustworthy Clinical Translation

    Aug 31, 2026Bahar İlgen, Yiannos Tolias, Denise Kühnert +5Cancer GenomicsOncology

    1*Centre for Artificial Intelligence in Public Health Research (ZKI-PH),2026 Robert Koch Institute, Nordufer 20, Berlin, 13353, Germany. · 2Directorate-General for Health and Food Safety, European Commission, Rue de Loi 200, Brussels, B-1049, Belgium.Aug · Department of Natural Sciences, School of Science and Technology, Deree-The American College of Greece, Gravias 6, Athens, 15342,31 Greece. +5

  6. Orchestra: Corroboration-Based Regulatory Candidate Discovery via Composed Bioinformatics MCP Agents

    Aug 27, 2026Jose A. BirdCancer GenomicsMulti-Agent Orchestration

    Independent Researcher, Bird AI Solutions

  7. PerturbRx: Learning Treatment-Conditioned Latent Transitions for Patient Drug Response Prediction

    Aug 21, 2026Yoshitaka Inoue, Minoh Jeong, Alfred Hero +2Cancer Drug Response PredictionPredictive Representation Learning

    Department of Computer Science, University of Minnesota, Minneapolis, MN, USA · Computational Biology Branch, National Library of Medicine, Bethesda, MD, USA · Therapeutic Development Branch, National Library of Medicine, Bethesda, MD, USA +2

  8. DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification

    Aug 19, 2026Jana T. Winterstein, Lukas Heinlein, Günter Raddatz +34Skin Lesion ClassificationCancer Genomics

    Division of Digital Prevention, Diagnostics and Therapy Guidance, German Cancer Research Center (DKFZ), INF 223, 69120 Heidelberg, Germany · Medical Faculty, University Heidelberg, Heidelberg, Germany · Department of Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany +24

  9. PET/CT Radiogenomic Mutation Prediction in Non-Small Cell Lung Cancer Using Multi-Label Learning

    Aug 10, 2026Mona Furukawa, Sai Hyne, Daniel R. McGowan +1Cancer GenomicsMulti-Label Classification

    Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK · Department of Radiology, Oxford University Hospitals NHS FT, Churchill Hospital, Oxford, UK · Department of Oncology, University of Oxford, Oxford, UK +1

  10. CASCADE: An Agentic Regulatory Network Framework for Patient-Data-Validated Downstream Perturbation Prediction

    Aug 5, 2026Jose A. BirdCancer GenomicsGenomics

    Independent Researcher

  11. CLARA: Clarification of Language Ambiguity through Result Analysis for Natural-Language Cancer Genomics Queries

    Aug 3, 2026Pratyush Kumar Shukla, Manveer Singh Tib, Siddhant GargCancer GenomicsClarification Question Generation

    Independent Researchers

  12. Foundation-model-guided radiogenomic discovery linking cancer genomes to cancer scans

    Jul 22, 2026Frederik Hauke, Jeremias Krause, Patrick Wienholt +6Cancer GenomicsOncology

    Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany · Center for Human Genetics and Genomic Medicine, University Hospital RWTH Aachen, Aachen, Germany · Department of Nephrology, Rheumatology and Immunology (Medical Clinic II), University Hospital RWTH Aachen, Aachen, Germany +3

  13. Predicting Therapeutic Outcome via Aligning Patient-Specific Knowledge Graph and Gene-Level Perturbation Representations

    Jul 6, 2026Dongmin Bang, Sugyun An, Inyoung Sung +3Cancer GenomicsHealthcare

    Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea · AIGENDRUG Co., Ltd., Seoul, Republic of Korea · BK21 FOUR Intelligence Computing, Seoul National University, Seoul, Republic of Korea +2

  14. SHIFT: Survival Prediction from Incomplete and Heterogeneous Genomic Data

    Jul 4, 2026Muhammet Sami Yavuz, Ayhan Can Erdur, Sabri Mustafa Kahya +2Cancer GenomicsCancer Survival Prediction

    AI for Image-Guided Diagnosis and Therapy, School of Medicine and Health, Technical University of Munich (TUM), Munich, Germany · Munich Center for Machine Learning (MCML) · Department of Radiation Oncology, TUM University Hospital +4

  15. Explainable AI for Cancer Drug Response Prediction: Beyond Univariate Feature Attributions

    Jul 1, 2026Martino Ciaperoni, Margherita Lalli, Simone Piaggesi +6Cancer GenomicsFeature Attribution

    KDD Lab, Scuola Normale Superiore Pisa, Italy · KDD Lab, University of Pisa Pisa, Italy · EMBL-EBI Hinxton, United Kingdom +1

  16. JASPR: Joint Spatial Representation learning of histology and spatial genomics for improved virtual genomic screening and clinical prognostication

    Jun 24, 2026Marija Pizurica, Eric Zimmermann, Neil Tenenholtz +5Cancer GenomicsComputational Pathology

    Microsoft Research, Cambridge, MA, United States · Stanford University, CA, United States

  17. A Bayesian Boolean Matrix Factorization with Application to Copy Number Analysis in Cancer

    Jun 16, 2026Adolphus Wagala, Mehmet Samur, Giovanni ParmigianiCancer GenomicsBayesian Inference

    Department of Data Science, Dana-Farber Cancer Institute · Department of Biostatistics, Harvard T.H. Chan School of Public Health

  18. OncoTraj: a public benchmark for longitudinal resistance prediction in EGFR-mutant non-small-cell lung cancer on osimertinib

    Jun 9, 2026Abhijoy Sarkar, Aarchi Singh ThakurCancer GenomicsClinical Outcome Prediction

    Span AI

  19. TRAPS: Therapeutic Response Analysis via Pathway-informed Stratification

    Jun 5, 2026Sujoy Banik, Sayantan Chakraborty, Boishakhi Das Toma +4Cancer GenomicsCancer Survival Prediction

    Rajshahi University of Engineering & Technology Bangladesh · University of Dhaka Bangladesh · American International University of Bangladesh Bangladesh +2

  20. Graph neural network explanations reveal a topological signature of disease-associated hubs in biological networks

    May 8, 2026Kyle Higgins, Ivan Laponogov, Dennis Veselkov +1Cancer GenomicsFeature Attribution

    1Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. · Department of Computing, Imperial College London, U.K. · Department of Environmental Health Sciences, Yale University, New Haven, CT, USA.

  21. PPI-Net connects molecular protein interactions to functional processes in disease

    May 8, 2026Kyle Higgins, Guadalupe Gonzalez, Dennis Veselkov +2Cancer GenomicsGraph Neural Networks

    Division of Cancer, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. · Prescient Design, Genentech, South San Francisco, CA, USA. · Department of Computing, Imperial College London, U.K.

  22. PathMoG: A Pathway-Centric Modular Graph Neural Network for Multi-Omics Survival Prediction

    Apr 27, 2026Di Wang, Chupei Tang, Junxiao Kong +3Survival AnalysisGraph Neural Networks

    1Cuiying Honors College, Lanzhou University, China · School of Mathematics and Statistics, Lanzhou University, China · School of Mathematics and Statistics, Lanzhou University, China and Shanghai Innovation Institute +1

  23. Graph Transformer-Based Pathway Embedding for Cancer Prognosis

    Apr 17, 2026Koushik Howlader, Md Tauhidul Islam, Wei LeCancer GenomicsCancer Survival Prediction

    Iowa State University, Iowa, USA · Stanford University, CA, USA

  24. RegNetAgents: A Multi-Agent Framework for Cross-Network Regulatory Driver Identification in Cancer Genomics

    Apr 16, 2026Jose A. BirdCancer Genomics

    Bird AI Solutions

  25. Mamba-SSM with LLM Reasoning for Feature Selection: Faithfulness-Aware Biomarker Discovery

    Apr 15, 2026Pushpa Kumar Balan, Aijing FengFeature SelectionScientific Discovery

    Department of Computer Science and Cybersecurity, University of Central Missouri

  26. Combining Bayesian and Frequentist Inference for Laboratory-Specific Performance Guarantees in Copy Number Variation Detection

    Apr 15, 2026Austin Talbot, Alex V. Kotlar, Yue KeUncertainty CalibrationGenomics

    Pillar Biosciences Inc Natick, MA, USA

  27. Pan-Cancer Mapping of the Tumor Immune Landscape through Metagene Clustering and Predictive Modeling

    Mar 28, 2026Soham ChatterjeeCancer Subtype ClassificationOncology

  28. Dictionary-based Pathology Mining with Hard-instance-assisted Classifier Debiasing for Genetic Biomarker Prediction from WSIs

    Mar 26, 2026Ling Zhang, Boxiang Yun, Ting Jin +3Computational PathologyHistopathology Image Classification

    Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai, China · Department of General Surgery, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China

  29. SynLeaF: A Dual-Stage Multimodal Fusion Framework for Synthetic Lethality Prediction Across Pan- and Single-Cancer Contexts

    Mar 23, 2026Zheming Xing, Siyuan Zhou, Ruinan Wang +9Multimodal FusionCancer Genomics

    1*School of Computer Science and Technology, Harbin Institute of Technology (Shenzhen), Shenzhen, Guang Dong 518055, China. · School of Biomedical Sciences, The University of Hong Kong, Hong Kong SAR, China. · 4Departments of Mathematics and Computer Science, Hong Kong Baptist University, Hong Kong SAR, China. +1

  30. Contextual Invertible World Models: A Neuro-Symbolic Agentic Framework for Colorectal Cancer Drug Response

    Mar 1, 2026Christopher Baker, Tianyu Ren, Karen Rafferty +1Cancer Drug Response PredictionWorld Models

    School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, United Kingdom