Latest papers 274

30 papers in the last four weeks, down 6% on the four weeks before. 0.2% of all new papers.

May 9, 2026

The Direct Integration Theorem: A Rigorous Framework for Consistent Discrete Solutions of the Inverse Radon Problem

This paper presents a novel Direct Integration Theorem (DIT), derived as a non-trivial corollary of the classical Central Slice Theorem (CST). The DIT provides a mathematically consistent transition from the continuous to the discrete domain - a fundamental challenge in computed tomography - thereby eliminating the need for frequency-domain interpolation without resorting to conventional ramp-filtering. The proposed approach circumvents two principal limitations inherent in traditional methods: (i) the zero-frequency singularity and spectral distortions introduced by the mandatory ramp-filtering step, and (ii) discretization inaccuracies associated with frequency-domain interpolation. Based on the DIT, we develop a rigorous framework for consistent discrete solutions of the inverse Radon problem. Mathematical modeling demonstrates that this approach achieves quasi-exact reconstruction, with errors constrained solely by sampling parameters and grid geometry. Furthermore, while Filtered Back Projection (FBP) inherently distorts the variance of the reconstructed image, the DIT-based algorithm preserves it. Comparative simulations confirm that the proposed method eliminates common artifacts, such as intensity cupping, and consistently outperforms FBP in terms of PSNR, SSIM, and reprojection fidelity, faithfully restoring the original image's statistical characteristics.
May 8, 2026

EmambaIR: Efficient Visual State Space Model for Event-guided Image Reconstruction

Recent event-based image reconstruction methods predominantly rely on Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) to process complementary event information. However, these architectures face fundamental limitations: CNNs often fail to capture global feature correlations, whereas ViTs incur quadratic computational complexity (e.g., O(n2)O(n^2)), hindering their application in high-resolution scenarios. To address these bottlenecks, we introduce EmambaIR, an Efficient visual State Space Model designed for image reconstruction using spatially sparse and temporally continuous event streams. Our framework introduces two key components: the cross-modal Top-k Sparse Attention Module (TSAM) and the Gated State-Space Module (GSSM). TSAM efficiently performs pixel-level top-k sparse attention to guide cross-modal interactions, yielding rich yet sparse fusion features. Subsequently, GSSM utilizes a nonlinear gated unit to enhance the temporal representation of vanilla linear-complexity (O(n)O(n)) SSMs, effectively capturing global contextual dependencies without the typical computational overhead. Extensive experiments on six datasets across three diverse image reconstruction tasks - motion deblurring, deraining, and High Dynamic Range (HDR) enhancement - demonstrate that EmambaIR significantly outperforms state-of-the-art methods while offering substantial reductions in memory consumption and computational cost. The source code and data are publicly available at: https://github.com/YunhangWickert/EmambaIR
May 8, 2026

PET-Adapter: Test-Time Domain Adaptation for Full and Limited-Angle PET Image Reconstruction

Positron Emission Tomography (PET) image reconstruction is inherently challenged by Poisson noise and physical degradation factors, which are further exacerbated in limited-angle acquisitions. While deep learning methods demonstrate promising performance, their generalization to unseen clinical data distributions remains limited without extensive retraining. We propose PET-Adapter, a test-time domain adaptation framework for generative PET reconstruction models pretrained solely on phantom data. Our method enables adaptation to clinical datasets with varying anatomies, tracers, and scanner configurations without requiring paired ground truth. PET-Adapter introduces layer-wise low-rank anatomical conditioning during adaptation and Ordered Subset Expectation Maximization-based warm-starting that initializes the generation from physics-informed reconstructions, reducing diffusion steps from 50 to 2 without compromising quality. Experiments across multiple clinical datasets demonstrate superior 3D reconstruction performance in both full-angle and limited-angle settings, highlighting the clinical feasibility and computational efficiency of the proposed approach.
May 7, 2026

The frame-level leakage trap: rethinking evaluation protocols for intrinsic image decomposition, with source-separable uncertainty as a case study

Evaluation protocols for learned intrinsic image decomposition on MPI Sintel have been inconsistent. Several prior works split the dataset by frames, which allows spatially similar frames of the same scene to appear in both train and test partitions. We quantify this leakage effect for the first time, across three architectures: a frame-level split inflates test R_PSNR by 1.6 to 2.0 dB (p less than 0.01 for all three, paired t-test across 3 seeds) relative to a scene-level split, confirming an architecture-independent protocol effect. A three-point gradient (random/temporal/scene) shows the gap is continuous, and under extended training the frame-level inflation exceeds 10 dB. We advocate scene-level splits as the community standard and provide reference numbers for six representative models under this protocol. As a case study within the corrected protocol, we present a physics-informed decomposition I = R composed with S + N with a source-separable three-way heteroscedastic uncertainty head. We empirically verify channel specialization: the non-Lambertian uncertainty channel shows r = 0.67 cross-correlation with non-Lambertian residual error, more than 4 times the texture channel's correlation. We further demonstrate downstream utility: filtering out the 75% highest-uncertainty pixels reduces reconstruction MSE by 77% on retained pixels, whereas random filtering produces no improvement. The specialization also holds on out-of-distribution real photographs. We report negative results for a more elaborate variant combining frequency decomposition, cross-task supervision, evidential learning, contrastive loss, and test-time adaptation. Our method reaches 15.98 plus or minus 0.41 dB R_PSNR, within 0.8 dB of a 5-member Deep Ensemble at one-fifth the cost, with the unique capability of source-separated uncertainty.
May 7, 2026

MUSE: Resolving Manifold Misalignment in Visual Tokenization via Topological Orthogonality

Unified visual tokenization faces a fundamental trade-off between high-fidelity pixel reconstruction (spatial equivariance) and semantic abstraction (conceptual invariance). We attribute this conflict to Manifold Misalignment: naive joint optimization induces opposing gradients, creating a zero-sum game between reconstruction and perception. To address this, we propose MUSE, a framework based on Topological Orthogonality. By treating Structure as an orthogonal bridge, MUSE decouples optimization within Transformers: structural gradients refine attention topology, while semantic gradients update feature values. This turns destructive interference into Mutual Reinforcement. Experiments show that MUSE breaks the trade-off, achieving state-of-the-art generation quality (gFID 3.08) and surpassing its teacher InternViT-300M in linear probing (85.2% vs. 82.5%), demonstrating that structurally aligned reconstruction can enhance semantic perception. Code is available at https://github.com/PanqiYang1/MUSE.
May 6, 2026

ViTok-v2: Scaling Native Resolution Auto-Encoders to 5 Billion Parameters

Vision Transformer (ViT) autoencoders have emerged as compelling tokenizers for images, offering improved reconstruction over convolutional tokenizers. However, existing ViT tokenizers cannot explore this landscape as performance degrades outside training resolutions, and reliance on adversarial losses prevents stable scaling. ViTok (Hansen-Estruch et al., 2025) found that the compression ratio r mediates a reconstruction-generation trade-off where lower r means better reconstructions but harder generations, so improving tokenizer reconstruction is key to more Pareto-optimal tokenizers. We introduce ViTok-v2, which addresses these limitations with native resolution support via NaFlex for generalization across resolutions and aspect ratios, and a novel DINOv3 perceptual loss that replaces both LPIPS and GAN objectives for stable training at any scale. ViTok-v2 is trained on about 2B images and scaled to 5B parameters, the largest image autoencoder to date. ViTok-v2 matches or exceeds state-of-the-art reconstruction at 256p and outperforms all baselines at 512p and above. In joint scaling experiments with flow matching generators, we show that scaling both the autoencoder and the generator advances the Pareto frontier of this trade-off.
May 5, 2026

Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction

Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the shared modules directly from limited raw measurements, removing the need for pre-acquired high-quality images. During test-time adaptation, only the subject-specific encoder is optimized, while the shared pair remains frozen, effectively preserving learned priors. Extensive evaluations on three representative medical imaging tasks show that DisINR significantly outperforms state-of-the-art INRs in both reconstruction accuracy and efficiency.
May 5, 2026

MK-ResRecon: Multi-Kernel Residual Framework for Texture-Aware 3D MRI Refinement from Sparse 2D Slices

Magnetic Resonance Imaging (MRI) acquisition remains a time-intensive and patient-straining process, as prolonged scan dura- tions increase the likelihood of motion artifacts, which degrade image quality and frequently require repeated scans. To address these chal- lenges, we propose a novel framework with two models MK-ResRecon and IdentityRefineNet3D to reconstruct high-fidelity 3D MRI volumes from sparsely sampled 2D slices-requiring only 12.5% of the axial slices for full resolution 3D reconstruction. MK-ResRecon predicts missing in- termediate 2D slices using a multi-kernel texture-aware loss, preserving fine anatomical details. IdentityRefineNet3D refines the predicted slices and the original sparse slices as a single 3D volume to obtain a smooth anatomical structure. We train the models on a large T1-sequence POST- contrast brain MRI dataset and evaluate on a large heterogeneous brain MRI cohort. The work provides accurate, hallucination-free, generaliz- able and clinically validated framework for 3D MRI reconstruction from highly sparse inputs and enables a clinically viable path towards faster and more patient-friendly MRI imaging.
May 4, 2026

ExpoCM: Exposure-Aware One-Step Generative Single-Image HDR Reconstruction

Single-image HDR reconstruction aims to recover high dynamic range radiance from a single low dynamic range (LDR) input, but remains highly ill-posed due to detail saturation in over-exposed regions and noise amplification in under-exposed areas. While recent diffusion-based approaches offer powerful generative priors, they often overlook the exposure-dependent nature of the degradation and incur substantial computational costs from iterative sampling. To address these challenges, we propose ExpoCM, a novel one-step generative HDR reconstruction framework that reformulates HDR reconstruction as a Probability Flow ODE (PF-ODE) and constructs exposure-aware consistency trajectories via exposure-dependent perturbations. Specifically, a soft exposure mask is first constructed to separate the LDR image into over-, under-, and well-exposed regions. Based on this partition, region-conditioned consistency trajectories are designed to hallucinate saturated details, suppress noise in dark regions, and preserve reliable structures within a single, distillation-free inference step. To further enhance perceptual quality, we introduce an Exposure-guided Luminance-Chromaticity Loss in the CIE~L∗a∗b∗\text{L}^*\text{a}^*\text{b}^* space, which assigns exposure-aware weights to luminance and chromaticity components, effectively mitigating brightness bias and color drift. Extensive experiments on the HDR-REAL, HDR-EYE, and AIM2025 benchmarks demonstrate that ExpoCM achieves state-of-the-art fidelity and perceptual accuracy, while enabling over 400×\times and 20×\times faster inference compared to DDPM (1000 steps) and DDIM (50 steps), respectively.
May 1, 2026

Machine Learning-Augmented Acceleration of Iterative Ptychographic Reconstruction

Iterative ptychographic reconstruction algorithms are widely used for coherent diffractive imaging but can exhibit slow convergence under realistic experimental conditions. We propose a machine learning-augmented approach that accelerates iterative ptychographic reconstruction by introducing a learned fast-forward operator applied during reconstruction. Following an initial warm-up using standard iterations, the fast-forward operator advances the reconstruction toward a more converged state, after which conventional iterative updates are resumed. This strategy preserves the physical consistency and flexibility of established ptychographic solvers while reducing the number of iterations required for convergence. The model is trained on diverse ptychographic datasets and evaluated on experimental data acquired in a different year, demonstrating robustness and temporal generalization. Compared with conventional iterative solvers, the machine learning-augmented method achieves comparable reconstruction quality while converging faster in terms of Poisson negative log-likelihood, yielding over a two-fold reduction in wall-clock time. The approach has been integrated into an existing reconstruction pipeline and deployed in production at a synchrotron beamline, demonstrating practicality for real-time experimental operation.
Apr 30, 2026

RayFormer: Modeling Inter- and Intra-Ray Similarity for NeRF-Based Video Snapshot Compressive Imaging

Video snapshot compressive imaging (SCI) enables the reconstruction of dynamic scenes from a single snapshot measurement. Recently, NeRF-based methods have shown promising reconstruction performance. However, such methods typically adopt random ray sampling strategies and fail to capture content structural similarities, resulting in limited reconstruction quality. To address these issues, we first propose a patch-level ray sampling strategy to enable the modeling of content structure. Then, we propose an Inter- and Intra-Ray Transformer (RayFormer) to capture the structural similarities, modeling both inter-ray similarities among spatially neighboring points at the same depth and intra-ray correlations between adjacent points along the viewing ray. Finally, benefiting from the patch-level sampling strategy, the total variation prior is incorporated into the objective function to enhance spatial smoothness and suppress artifacts. Experiments in both simulated and real-world scenes demonstrate that the proposed method achieves state-of-the-art (SOTA) reconstruction performance.
Apr 30, 2026

FUN: A Focal U-Net Combining Reconstruction and Object Detection for Snapshot Spectral Imaging

Conventional push-broom hyperspectral imaging suffers from slow acquisition speeds, precluding real-time object detection; in contrast, snapshot spectral imaging enables instantaneous hyperspectral images (HSIs) capture, making real-time object detection feasible, yet its potential is often compromised by time-consuming post-capture reconstruction. To address this issue, we propose the Focal U-shaped Network (FUN), a novel end-to-end framework that jointly performs HSI reconstruction and object detection via multi-task learning. FUN employs a shared U-shaped backbone, where reconstruction provides underlying spectral information while detection guides semantic-aware priors learning, facilitating mutually beneficial task interaction. Crucially, we introduce focal modulation, an efficient alternative to self-attention that modulates spatial and spectral features while reducing quadratic computational complexity, enabling a self-attention-free architecture for joint reconstruction and detection. Furthermore, we contribute a new HSI object detection dataset with 8712 annotated objects across 363 HSIs to facilitate evaluation of the proposed method. Experiments demonstrate that FUN achieves state-of-the-art performance on both tasks, using 40% fewer parameters and 30% less computation than recent alternatives, making it promising for future real-time edge deployment. The code and datasets are available: https://github.com/ShawnDong98/FUN.
Apr 29, 2026

Circular Phase Representation and Geometry-Aware Optimization for Ptychographic Image Reconstruction

Traditional iterative reconstruction methods are accurate but computationally expensive, limiting their use in high-throughput and real-time ptychography. Recent deep learning approaches improve speed, but often predict phase as a Euclidean scalar despite its 2π2π periodicity, which can introduce wrapping artifacts, discontinuities at ±π\pmπ, and a mismatch between the loss and the underlying signal geometry. We present a deep learning framework for ptychographic reconstruction that models phase on the unit circle using cosine and sine components. Phase error is optimized with a differentiable geodesic loss, which avoids branch-cut discontinuities and provides bounded gradients. The network further incorporates saturation-aware dual-gain input scaling, parallel encoder branches, and three decoders for amplitude, cosine, and sine prediction, together with a composite loss that promotes circular consistency and structural fidelity. Experiments on synthetic and experimental datasets show consistent improvements in both amplitude and phase reconstruction over existing deep learning methods. Frequency-domain analysis further shows better preservation of mid- and high-frequency phase content. The proposed method also provides substantial speedup over iterative solvers while maintaining physically consistent reconstructions.
Apr 27, 2026

Shared-kernel Wavelet Neural Networks for Poisson Image Reconstruction

The Laplacian operator transforms the image into its Laplacian field, which usually is sparse and satisfies a stable distribution. On the other hand, an image can be uniquely reconstructed from its Laplacian field via solving a Poisson equation with a proper boundary condition. Such uniqueness is mathematically guaranteed. Thanks to these properties, we propose to use the sparse Laplacian field to present the image. We first show that the Laplacian field is sparse and satisfies a stable distribution on hundreds images. Then, we show that the image can be accurately reconstruct from its Laplacian field. For the reconstruction task, we propose a shared-kernel wavelet neural network, which solves the Poisson equation and has three advantages. First, it has less than {\bf 0.0002M} parameters, which is compact enough for most of devices. Second, it has linear computation complexity, leading to a real-time reconstruction. Third, it achieves higher accuracy than previous methods. Several numerical experiments are conducted to show the effectiveness and efficiency of the sparse Laplacian field and the proposed Poisson solver. The proposed method can be applied in a large range of applications such as image compression, low light enhancement, object tracking, etc.
Apr 26, 2026

Focus on What Matters: Two-Stage ROI-Aware Refinement for Anatomy-Preserving Fetal Ultrasound Reconstruction

Measurement-critical ultrasound tasks often depend on a small anatomical region, making global reconstruction metrics an unreliable proxy for clinical fidelity. We propose an ROI-aware representation learning framework and instantiate it for first-trimester nuchal translucency (NT) screening under multi-hospital domain shift. A two-phase convolutional autoencoder (CAE) first learns a globally faithful 128-D latent code via MS-SSIM, then refines the NT ROI using intensity (L1) and normalized Sobel-edge constraints. To combine these heterogeneous objectives without manual tuning, we initialize loss weights via gradient-based calibration from per-term gradient magnitudes. Under strict hospital-wise evaluation with one hospital held out, ROI refinement improves both global and measurement-relevant quality: on the standard dev split it increases PSNR by +0.27 dB (val) and +0.29 dB (held-out test), reduces ROI MAE by 8.87% (val) and 6.43% (held-out test), and reduces ROI Edge-MAE by 11.10% on source hospitals and 4.90% on the unseen hospital. Beyond reconstruction, frozen-latent probes provide additional evidence of generalization: hospital provenance becomes less confidently predictable on the unseen site (0.556 to 0.541 max-softmax; 0.684 to 0.688 entropy) while OOD detection remains strong across site-held-out protocols (Mahalanobis AUROC up to 0.9956, with modest KNN gains in challenging splits). The same ROI-aware refinement principle is anatomy-agnostic and can be adopted for other fetal biometry targets (e.g., crown-rump length (CRL), nasal bone (NB)) and broader medical imaging settings where small ROIs dominate clinical decisions.
Apr 26, 2026

ShredBench: Evaluating the Semantic Reasoning Capabilities of Multimodal LLMs in Document Reconstruction

Multimodal Large Language Models (MLLMs) have achieved remarkable performance in Visually Rich Document Understanding (VRDU) tasks, but their capabilities are mainly evaluated on pristine, well-structured document images. We consider content restoration from shredded fragments, a challenging VRDU setting that requires integrating visual pattern recognition with semantic reasoning under significant content discontinuities. To facilitate systematic evaluation of complex VRDU tasks, we introduce ShredBench, a benchmark supported by an automated generation pipeline that renders fragmented documents directly from Markdown. The proposed pipeline ensures evaluation validity by allowing the flexible integration of latest or unseen textual sources to prevent training data contamination. ShredBench assesses four scenarios (English, Chinese, Code, Table) with three fragmentation granularities (8, 12, 16 pieces). Empirical evaluations on state-of-the-art MLLMs reveal a significant performance gap: The method is effective on intact documents; however, once the document is shredded, restoration becomes a significant challenge, with NED dropping sharply as fragmentation increases. Our findings highlight that current MLLMs lack the fine-grained cross-modal reasoning required to bridge visual discontinuities, identifying a critical gap in robust VRDU research.
Apr 26, 2026

GS-DOT: Gaussian splatting-based image reconstruction for diffuse optical tomography

This work presents GS-DOT, a novel image reconstruction framework based on Gaussian Splatting (GS) for diffuse optical tomography (DOT). Inspired by GS for rendering applications, absorption coefficients are represented as a sparse sum of anisotropic Gaussian primitives optimized to fit measured time-resolved point-spread functions through analytic gradients and Adam optimization. This is the first adaptation of GS algorithms in the photon diffusion regime, where the ray transport function is replaced by the diffusion functions to enable accurate modeling of light transport in highly scattering media. Validation on synthetic tissue models demonstrate high accuracy in localization and quantification of reconstructed absorption maps for both clean and noisy signals. GS-DOT has demonstrated high robustness to noise and showed a huge reduction in memory demand.
Apr 25, 2026

LatentBurst: A Fast and Efficient Multi Frame Super-Resolution for Hexadeca-Bayer Pattern CIS images

This paper introduces a novel multi frame super-resolution network (MFSR) for burst hexadeca Bayer pattern Contact Image Sensor (CIS) images, which includes demosaicing, denoising, multi-frame fusion, and super-resolution. Designing a high-quality reconstruction network poses several challenges as follows: 1) Unlike the Bayer color filter array (CFA) pattern, it is hard to interpolate hexadeca-Bayer pattern since the pixel distance between the same color groups increases; 2) Due to large object motion and camera movements, the final fusion result usually suffers the misalignment resulting a blurry image or ghosting artifacts; 3) The proposed network should be fast and efficient enough to operate in real-time on mobile devices. To overcome these challenges, we propose a novel network, called LatentBurst, which contains: 1) a pyramid align and fusion approach in latent feature to deal with large motion scenario; 2) an efficient UNet-based structure which can run efficiently on mobile device; 3) fine-tuned optical flow estimation and two-step knowledge distillation to reduce domain-gap more effectively. Experimental results in various scenarios demonstrate the effectiveness of our proposed method compared with other state-of-the-art methods.
Apr 24, 2026

Structure-Guided Diffusion Model for EEG-Based Visual Cognition Reconstruction

Objective: Decoding visual information from electroencephalography (EEG) is an important problem in neuroscience and brain-computer interface (BCI) research. Existing methods are largely restricted to natural images and categorical representations, with limited capacity to capture structural features and to differentiate objective perception from subjective cognition. We propose a Structure-Guided Diffusion Model (SGDM) that incorporates explicit structural information for EEG-based visual reconstruction. Approach: SGDM is evaluated on the Kilogram abstract visual object dataset and the THINGS natural image dataset using a two-stage generative mechanism. The framework combines a structurally supervised variational autoencoder with a spatiotemporal EEG encoder aligned to a visual embedding space via contrastive learning. Structural information is integrated into a diffusion model through ControlNet to guide image generation from EEG features. Results: SGDM outperforms existing methods on both abstract and natural image datasets. Reconstructed images achieve higher fidelity in low-level visual features and semantic representations, indicating improved decoding accuracy and strong generalization across diverse visual domains. Spatiotemporal analysis of EEG signals further reveals hierarchical structural encoding patterns, consistent with the neural dynamics of visual cognition. Significance: These findings validate the effectiveness of SGDM in capturing explicit structural geometry and generating images with high fidelity to individual cognitive representations. By enabling decoding of complex visual content from EEG signals, the framework extends neural decoding beyond low-dimensional or categorical outputs. This supports BCIs with increased degrees of freedom for intention decoding and more flexible brain-to-machine communication.
Apr 22, 2026

Optimizing Diffusion Priors in Image Reconstruction from a Single Observation

While diffusion priors generate high-quality posterior samples across many inverse problems, they are often trained on limited training sets or purely simulated data, thus inheriting the errors and biases of these underlying sources. Current approaches to finetuning diffusion models rely on a large number of observations with varying forward operators, which can be difficult to collect for many applications, and thus lead to overfitting when the measurement set is small. We propose a method for tuning a prior from only a single observation by combining existing diffusion priors into a single product-of-experts prior and identifying the exponents that maximize the Bayesian evidence. We validate our method on real-world inverse problems, including black hole imaging, where the true prior is unknown a priori, and image deblurring with text-conditioned priors. We find that the evidence is often maximized by priors that extend beyond those trained on a single dataset. By generalizing the prior through exponent weighting, our approach enables posterior sampling from both tempered and combined diffusion models, yielding more flexible priors that improve the trustworthiness of the resulting posterior image distribution.
Apr 22, 2026

Physics-Informed Conditional Diffusion for Motion-Robust Retinal Temporal Laser Speckle Contrast Imaging

Retinal laser speckle contrast imaging (LSCI) is a noninvasive optical modality for monitoring retinal blood flow dynamics. However, conventional temporal LSCI (tLSCI) reconstruction relies on sufficiently long speckle sequences to obtain stable temporal statistics, which makes it vulnerable to acquisition disturbances and limits effective temporal resolution. A physically informed reconstruction framework, termed RetinaDiff (Retinal Diffusion Model), is proposed for retinal tLSCI that is robust to motion and requires only a few frames. In RetinaDiff, registration based on phase correlation is first applied to stabilize the raw speckle sequence before contrast computation, reducing interframe misalignment so that fluctuations at each pixel primarily reflect true flow dynamics. From the long registered sequence this step yields a high-quality multiframe tLSCI map that serves only as the reconstruction target, while a motion-corrected contrast prior is computed independently from the few input frames. Next, guided by this prior, a conditional diffusion model performs inverse reconstruction by jointly conditioning on the registered few-frame sequence and the prior. On stable sequences acquired with an in-house retinal LSCI system, RetinaDiff improved SSIM from 0.159 to 0.533, PSNR from 14.83 to 18.06 dB, and FID from 211.50 to 111.55 compared with direct five-frame reconstruction, showing improved structural continuity and statistical stability over representative baselines. The framework also remains effective in a small number of extremely challenging cases, where both the direct five-frame input and the conventional multiframe reconstruction are severely degraded. Overall, this work provides a practical and physically grounded route for reliable retinal tLSCI reconstruction from extremely limited frames. The source code and model weights will be released upon acceptance.
Apr 22, 2026

Maximum Likelihood Reconstruction for Multi-Look Digital Holography with Markov-Modeled Speckle Correlation

Multi-look acquisition is a widely used strategy for reducing speckle noise in coherent imaging systems such as digital holography. By acquiring multiple measurements, speckle can be suppressed through averaging or joint reconstruction, typically under the assumption that speckle realizations across looks are statistically independent. In practice, however, hardware constraints limit measurement diversity, leading to inter-look correlation that degrades the performance of conventional methods. In this work, we study the reconstruction of speckle-free reflectivity from complex-valued multi-look measurements in the presence of correlated speckle. We model the inter-look dependence using a first-order Markov process and derive the corresponding likelihood under a first-order Markov approximation, resulting in a constrained maximum likelihood estimation problem. To solve this problem, we develop an efficient projected gradient descent framework that combines gradient-based updates with implicit regularization via deep image priors, and leverages Monte Carlo approximation and matrix-free operators for scalable computation. Simulation results demonstrate that the proposed approach remains robust under strong inter-look correlation, achieving performance close to the ideal independent-look scenario and consistently outperforming methods that ignore such dependencies. These results highlight the importance of explicitly modeling inter-look correlation and provide a practical framework for multi-look holographic reconstruction under realistic acquisition conditions. Our code is available at: https://github.com/Computational-Imaging-RU/MLE-Holography-Markov.
Apr 21, 2026

Deep Image Prior for photoacoustic tomography can mitigate limited-view artifacts

We study the deep image prior (DIP) framework applied to photoacoustic tomography (PAT) as an unsupervised reconstruction approach to mitigate limited-view artifacts and noise commonly encountered in experimental settings. Efficient implementation is achieved by employing recently published fast forward and adjoint algorithms for circular measurement geometries. Initialization via a fast inverse and total variation (TV) regularization are applied to further suppress noise and mitigate overfitting. For comparison, we compute a classical TV reconstruction. Our experiments comprise simulated PAT measurements under limited-view geometries and varying levels of added noise as well as experimental measurements together with using a digital twin for quality assessment. Our findings suggest that DIP framework provides an effective unsupervised strategy for robust PAT reconstruction even in the challenging case of a limited view geometry providing improvement in several quantitative measures over total variation reconstructions.
Apr 20, 2026

LBFTI: Layer-Based Facial Template Inversion for Identity-Preserving Fine-Grained Face Reconstruction

In face recognition systems, facial templates are widely adopted for identity authentication due to their compliance with the data minimization principle. However, facial template inversion technologies have posed a severe privacy leakage risk by enabling face reconstruction from templates. This paper proposes a Layer-Based Facial Template Inversion (LBFTI) method to reconstruct identity-preserving fine-grained face images. Our scheme decomposes face images into three layers: foreground layers (including eyebrows, eyes, nose, and mouth), midground layers (skin), and background layers (other parts). LBFTI leverages dedicated generators to produce these layers, adopting a rigorous three-stage training strategy: (1) independent refined generation of foreground and midground layers, (2) fusion of foreground and midground layers with template secondary injection to produce complete panoramic face images with background layers, and (3) joint fine-tuning of all modules to optimize inter-layer coordination and identity consistency. Experiments demonstrate that our LBFTI not only outperforms state-of-the-art methods in machine authentication performance, with a 25.3% improvement in TAR, but also achieves better similarity in human perception, as validated by both quantitative metrics and a questionnaire survey.
Apr 18, 2026

Structured 3D-SVD: A Practical Framework for the Compression and Reconstruction of Biological Volumetric Images

This work introduces Structured 3D-SVD as a practical framework for the reconstruction, compression, and analysis of biological volumetric data. Inspired by the logic of matrix singular value decomposition (SVD), the proposed approach represents third-order volumetric data in the spatial domain and supports progressive reconstruction through ordered quasi-singular coeffients. The experimental evaluation was carried out on two biological volumetric datasets: one full-volume scan of a fish and another of a brain. The results show that Structured 3D-SVD achieves reconstruction quality close to that of Tucker decomposition while requiring shorter computation times and outperforms canonical polyadic decomposition (CPD) in both accuracy and runtime. In addition, a progressive reconstruction analysis shows that relatively low truncation levels are sufficient to preserve the main volumetric structures, while higher truncation levels lead to more detailed reconstructions.
Apr 18, 2026

Applications of deep generative models to DNA reaction kinetics and to cryogenic electron microscopy

This dissertation explores how deep generative models can advance the analysis of challenging biological problems by integrating domain knowledge with deep learning. It focuses on two areas: DNA reaction kinetics and cryogenic electron microscopy (cryo-EM). In the first part, we present ViDa, a biophysics-informed framework leveraging variational autoencoders (VAEs) and geometric scattering transforms to generate biophysically-plausible embeddings of DNA reaction kinetics simulations. These embeddings are reduced to a two-dimensional space to visualize DNA hybridization and toehold-mediated strand displacement reactions. ViDa preserves structure and clusters trajectory ensembles into reaction pathways, making simulation results more interpretable and revealing new mechanistic insights. In the second part, we address key challenges in cryo-EM density map interpretation and protein structure modeling. We provide a comprehensive review and benchmarking of deep learning methods for atomic model building, with improved evaluation metrics and practical guidance. We then present Struc2mapGAN, a generative adversarial network that synthesizes high-fidelity experimental-like cryo-EM density maps from protein structures. Finally, we present CryoSAMU, a structure-aware multimodal U-Net that enhances intermediate-resolution cryo-EM maps by integrating density features with structural embeddings from protein language models via cross-attention. Overall, these contributions demonstrate the potential of deep generative models to interpret DNA reaction mechanisms and advance cryo-EM density map analysis and protein structure modeling.
Apr 18, 2026

Improving Radio Interferometry Imaging by Explicitly Modeling Cross-Domain Consistency in Reconstruction

Radio astronomy plays a crucial role in understanding the universe, particularly within the realm of non-thermal astrophysics. Images of celestial objects are derived from the signals (called visibility) measured by radio telescopes. Such imaging results, called dirty images, contain artifacts due to factors such as sparsity and therefore require reconstruction to improve imaging quality. Existing methods typically restrict reconstruction to a unimodal domain, either to the dirty image after imaging or to the sparse visibility prior to imaging. Focusing solely on each unimodal reconstruction results in the loss of complementary in-context information in either the visibility or image domain, leading to an incomplete modeling of mutual dependency and consistency. To address these challenges, we propose CDCRec, a multimodal radio interferometric data reconstruction method that explicitly models cross-domain consistency. We design a hierarchical multi-task and multi-stage framework to enhance the exploration of interplays between domains during reconstruction. Our experimental results demonstrate that CDCRec improves imaging performance through enhanced cross-domain correlation extraction. In particular, our self-supervised complementary modeling strategy is better than current methods at interferometric domain translations that rely heavily on recovering dense information from constrained source-domain data.
Apr 17, 2026

DENALI: A Dataset Enabling Non-Line-of-Sight Spatial Reasoning with Low-Cost LiDARs

Consumer LiDARs in mobile devices and robots typically output a single depth value per pixel. Yet internally, they record full time-resolved histograms containing direct and multi-bounce light returns; these multi-bounce returns encode rich non-line-of-sight (NLOS) cues that can enable perception of hidden objects in a scene. However, severe hardware limitations of consumer LiDARs make NLOS reconstruction with conventional methods difficult. In this work, we motivate a complementary direction: enabling NLOS perception with low-cost LiDARs through data-driven inference. We present DENALI, the first large-scale real-world dataset of space-time histograms from low-cost LiDARs capturing hidden objects. We capture time-resolved LiDAR histograms for 72,000 hidden-object scenes across diverse object shapes, positions, lighting conditions, and spatial resolutions. Using our dataset, we show that consumer LiDARs can enable accurate, data-driven NLOS perception. We further identify key scene and modeling factors that limit performance, as well as simulation-fidelity gaps that hinder current sim-to-real transfer, motivating future work toward scalable NLOS vision with consumer LiDARs.
Apr 17, 2026

Self-Supervised Angular Deblurring in Photoacoustic Reconstruction via Noisier2Inverse

Photoacoustic tomography (PAT) is an emerging imaging modality that combines the complementary strengths of optical contrast and ultrasonic resolution. A central task is image reconstruction, where measured acoustic signals are used to recover the initial pressure distribution. For ideal point-like or line-like detectors, several efficient and fast reconstruction algorithms exist, including Fourier methods, filtered backprojection, and time reversal. However, when applied to data acquired with finite-size detectors, these methods yield systematically blurred images. Although sharper images can be obtained by compensating for finite-detector effects, supervised learning approaches typically require ground-truth images that may not be available in practice. We propose a self-supervised reconstruction method based on Noisier2Inverse that addresses finite-size detector effects without requiring ground-truth data. Our approach operates directly on noisy measurements and learns to recover high-quality PAT images in a ground-truth-free manner. Its key components are: (i) PAT-specific modeling that recasts the problem as angular deblurring; (ii) a Noisier2Inverse formulation in the polar domain that leverages the known angular point-spread function; and (iii) a novel, statistically grounded early-stopping rule. In experiments, the proposed method consistently outperforms alternative approaches that do not use supervised data and achieves performance close to supervised benchmarks, while remaining practical for real acquisitions with finite-size detectors.
Apr 16, 2026

High-Speed Full-Color HDR Imaging via Unwrapping Modulo-Encoded Spike Streams

Conventional RGB-based high dynamic range (HDR) imaging faces a fundamental trade-off between motion artifacts in multi-exposure captures and irreversible information loss in single-shot techniques. Modulo sensors offer a promising alternative by encoding theoretically unbounded dynamic range into wrapped measurements. However, existing modulo solutions remain bottlenecked by iterative unwrapping overhead and hardware constraints limiting them to low-speed, grayscale capture. In this work, we present a complete modulo-based HDR imaging system that enables high-speed, full-color HDR acquisition by synergistically advancing both the sensing formulation and the unwrapping algorithm. At the core of our approach is an exposure-decoupled formulation of modulo imaging that allows multiple measurements to be interleaved in time, preserving a clean, observation-wise measurement model. Building upon this, we introduce an iteration-free unwrapping algorithm that integrates diffusion-based generative priors with the physical least absolute remainder property of modulo images, supporting highly efficient, physics-consistent HDR reconstruction. Finally, to validate the practical viability of our system, we demonstrate a proof-of-concept hardware implementation based on modulo-encoded spike streams. This setup preserves the native high temporal resolution of spike cameras, achieving 1000 FPS full-color imaging while reducing output data bandwidth from approximately 20 Gbps to 6 Gbps. Extensive evaluations indicate that our coordinated approach successfully overcomes key systemic bottlenecks, demonstrating the feasibility of deploying modulo imaging in dynamic scenarios.