Single-Cell Foundation Models

Latest papers 33

Sep 21, 2026cs.IT

On the Information-Theoretic Limits of Latent-Space Watermarking Through Pretrained Generators

We study latent-space watermarking through a pretrained generator using a prescribed latent-to-output stochastic mapping, called the renderer. A watermark encoder selects the latent input using a message and secret key. For every message and semantic context, the released output must have exactly the desired conditional output distribution. For finite alphabets, we derive rate--key inner and outer bounds and characterize the coding and coordination requirements for realizing watermark communication through the prescribed latent interface. When the target output distribution of the generator uniquely determines the corresponding latent input distribution through the renderer, a strengthened converse yields the capacity region; the same region governs explicit preservation of the pretrained latent distribution. We extend the analysis to general jointly Gaussian models and identify a sufficient statistic of the latent that captures both the watermark-bearing information available at the generated output and the latent coordination required to preserve its target distribution. For the vector Gaussian model, we further characterize the optimal allocation of the secret-key resource across the resulting modes. Finally, we turn to an emerging robustness threat that is particularly natural in generative watermarking: an adversary can regenerate the released sample to obtain a fresh realization of the same underlying content while attenuating or destroying the embedded watermark. We incorporate this robustness axis into our framework and characterize the one-pass compound capacity of the scalar Gaussian model when the semantic context is known to the encoder but hidden from the detector, while the regeneration attack may depend on that context. Extending the analysis to multiple rounds of repeated canonical regeneration, we characterize the resulting watermark-capacity decay.
Sep 15, 2026cs.CV

FRPSS: Feature Rearrangement in Pre-Shape Space for Single-Image Generation

Generative models trained on a single image often struggle to balance global structural integrity and local diversity. Existing single-image generation methods commonly rely on random noise to drive the generation process and lack explicit global structural constraints, making the generated results prone to spatial structural misalignment when structural variations occur. To address the issue, Feature Rearrangement in Pre-Shape Space for Single-Image Generation (FRPSS) is proposed in this paper. The core of FRPSS is the Manifold Structural Rearrangement with Feature Augmentation on Geodesic Surface (MSR-FAGS) module. MSR-FAGS replaces the randomly initialized features of the low-scale generator with rearranged Pre-Shape features and uses the features to guide image generation at subsequent scales, thereby reducing the risk of structural misalignment. To support downstream tasks such as stylization, a Scale-adaptive Sliding-window Patch Extraction (SSPE) strategy is further designed, and a directional Contrastive Language-Image Pre-training supervision module with SSPE (CLIP-SSPE) is constructed. Qualitative and quantitative experiments demonstrate that FRPSS achieves the best Single Image Fréchet Inception Distance (SIFID) scores on all three datasets while maintaining competitive Learned Perceptual Image Patch Similarity (LPIPS). Further qualitative experiments verify the effectiveness of FRPSS across multiple downstream tasks with the CLIP-SSPE module.
Sep 9, 2026cs.CV

Isotropic Embedding Perturbations for Robust Vision Language Encoders

Data augmentation is fundamental to training modern deep vision and multimodal models. While individual methods, such as RandAug, CutMix, Mixup, RandErase, and DropPath, offer strong regularization effects, their combined use has saturated in performance due to overlapping functionalities, and aggressive pixel-level manipulations may disrupt delicate cross-modal alignment. This saturation motivates the search for a new augmentation axis within the embedding space rather than the input space. We introduce Aether, a simple plug-in method that applies diffusion-style random perturbations in the embedding space via controlled alpha-mixing, specifically designed to provide isotropic regularization that remains semantically consistent. Inspired by feature-space perturbations in language models and image degradation in generative pretraining, Aether induces mild yet effective perturbations that smooth the representations without compromising the fine-grained structural information required for strong vision-language encoders. Across diverse architectures and across multiple recognition tasks, Aether delivers consistent gains over the advanced recipe combining CutMix, Mixup, DropPath, and RandAug---a level of improvement rarely observed with modern augmentation alternatives. Notably, Aether demonstrates superior effectiveness in multi-modal alignment, succeeding where traditional pixel-space augmentations fail by providing a stable, isotropic regularization signal that respects the integrity of the high-dimensional feature space.
Aug 6, 2026cs.CV

Robust-WAM: Bridging Generative Pretraining and Semantic Foresight in World-Action Models

Mainstream World-Action Models (WAMs) adapt pretrained video generation models (VGMs) for robot control, transferring their learned dynamics prior for action prediction. These VGMs are typically trained in a variational autoencoder (VAE) latent space. However, the VAE latent space is optimized for pixel reconstruction, which rewards fine appearance detail and leaves the action prediction fragile under visual shifts. Recent works build WAMs in semantic latent space, which are more robust to appearance shifts. However, these models cannot leverage the large-scale VGM pretraining that exists only in VAE space. To overcome this dilemma, we propose Robust-WAM, a general post-training method for video-generation-based WAMs that preserves the VAE-based generative path and adds a lightweight semantic foresight alignment objective on the action stream. This retains the large-scale VGM pretraining while grounding actions in appearance-invariant dynamics that stay reliable under illumination shifts and other visual out-of-distribution conditions. Specifically, we employ learnable query tokens to bring future-scene semantics into the action stream by aligning their output hidden states with the semantic foresight of future ground-truth frames. To establish the temporal correspondence between each query and the future step it describes, we give it the positional encoding of the matching action tokens. Experiments on out-of-distribution generalization simulation benchmarks and a real-robot setup show that our Robust-WAM consistently improves the success rates of multiple WAM baselines without sacrificing in-distribution performance.
Aug 4, 2026cs.CV

Self-Supervised Representation-Guided Generative Dataset Distillation

Dataset distillation compresses a large training set into a compact synthetic set while retaining its downstream utility. Most existing methods target randomly initialized networks, whereas modern vision systems often adapt frozen pretrained encoders with lightweight modules. Distilled samples should therefore preserve the discriminative geometry of the pretrained representation space, which existing generative objectives do not explicitly consider. We propose self-supervised representation-guided generative dataset distillation (SRG), a framework that translates the SSL geometry into diffusion guidance. Specifically, SRG constructs class-wise prototypes from real-image SSL representations and performs guidance through three SSL-space objectives for prototype alignment, inter-class discrimination, and intra-class assignment. During diffusion sampling, it adopts a stage-wise guidance strategy: early denoising is anchored to the latent of the real image whose SSL representation is nearest to the assigned prototype, whereas later denoising is guided by the SSL-space objectives. This division preserves the visual realism provided by the generative prior while progressively steering samples toward representative and class-discriminative regions of the SSL representation space. SRG consistently outperforms the evaluated generative baselines across multiple datasets and IPC settings. A cross-encoder evaluation further indicates transfer across pretrained representation spaces. These results demonstrate the effectiveness of representation-guided generation for dataset distillation with pretrained SSL models.
Aug 2, 2026cs.LG

Beyond Gene Reconstruction: Learning Cell Representations through Complementary Transcriptomic Views

The rapid growth of single-cell transcriptomic data has enabled the development of foundation models pretrained primarily by reconstructing masked expression values. This objective encourages these models to learn gene dependencies but does not directly optimize whole-cell representations, which are essential for many downstream tasks. To bridge this gap, we propose a contrastive pretraining framework that learns cell representations through complementary transcriptomic views. Since standard contrastive learning is not readily applicable to single-cell pretraining, we introduce specific adaptations along three dimensions --- co-expression-guided gene partitioning, expression-aware contrast-set construction, and competence-gated contrastive onset. Specifically, we first construct two complementary views of each cell by partitioning its genes according to their co-expression structure. Then, to prevent the model from using gene-set identity as a shortcut, we construct hard negatives by permuting expression values while keeping gene identities unchanged. Finally, we introduce a competence-aware controller to determine how the contrastive objective is applied. Experiments on cell-type annotation and gene regulatory network inference demonstrate competitive transfer under the evaluated protocols. In the six-network GRN evaluation, our method records the highest mean AUROC and AUPRC point estimates among the compared variants, while the highest-scoring variant differs across individual networks. These results establish complementary-view contrastive learning as an effective direction for single-cell pretraining beyond gene reconstruction.
Jul 18, 2026cs.CV

Test-Time Registers as Global Priors for Tokenized Image Generation

Attention-based models often develop attention sinks, where a small number of tokens repeatedly attract attention and accumulate unusually large activations. In vision transformers, these outliers are closely related to registers, which have been diagnostically linked to global, low-frequency image structure. Existing work has largely studied registers through interpretability analyses and linear probes, leaving open whether they can be operationalized as plug-and-play signals for generation without retraining. We revisit this question in tokenized image generation. Using OpenCLIP and DINOv2 on ImageNet, we find that test-time register features exhibit stronger low-frequency concentration than both [CLS] readouts and patch-mean features, and show a consistent (albeit moderate) correlation with pixel-space DCT low-frequency energy. Motivated by these diagnostics, we introduce RegToken, a training-free procedure that converts register structure into a small set of global prior tokens by (i) NFN-based layer localization, (ii) TokenRank-guided subspace extraction, and (iii) a projection-and-conservation update on the register subspace. Inserted into a frozen compact 1D token generation pipeline, RegToken improves ImageNet generation and alignment metrics (e.g., FID-5k 20.5 to 20.1, SigLIP 3.6 to 3.9) without modifying pretrained weights, and accelerates test-time optimization (Steps@ττ 74 to 52). Overall, our results suggest that structures often viewed as attention artifacts can be repurposed as lightweight global priors for tokenized generation.
Jul 13, 2026cs.CV

Read It Back: Pretrained MLLMs Are Zero-Shot Reward Models for Text-to-Image Generation

In this paper, we propose SpectraReward, a training-free reward function that turns pretrained MLLMs into off-the-shelf reward models for image-generation reinforcement learning. Instead of asking the MLLM to judge a generated image or answer decomposed verification questions, SpectraReward measures how well the original prompt can be recovered from the generated image through a single image-conditioned, teacher-forced forward pass. We use the average image-conditioned prompt log-likelihood as the reward, directly reusing the MLLM's pretrained image-text alignment ability without preference labels, reward-model fine-tuning. We further introduce Self-SpectraReward, a special case for unified multimodal models where the policy's own understanding branch serves as the reward model for its generation branch, forming a closed-loop self-improving framework without external reward models or external knowledge. Extensive experiments validate SpectraReward through a broad image-generation RL study covering two diffusion models, three RL algorithms, nine reward MLLM backbones from four MLLM families spanning 4B to 235B parameters, and five out-of-distribution text-to-image benchmarks. Results show that both SpectraReward and Self-SpectraReward significantly and consistently improve generation performance and outperform prior MLLM-derived reward training methods. Further analysis reveals that larger reward MLLMs are not always better, while Self-SpectraReward can match or surpass much larger external reward models, suggesting that reward-policy alignment is a key factor for effective image-generation RL. Project Page: https://huangrh99.github.io/SpectraReward/
Jul 13, 2026cs.CV

Slot-RAE: Streamlining Object-Centric Learning via Direct Representation Auto-Encoders

Deploying object-centric models for real-world scene understanding typically requires complex pipelines to achieve both robust scene decomposition and high-fidelity generation. Recent diffusion-based approaches have improved visual quality, but they almost universally rely on heavy, pretrained generative priors (e.g., Stable Diffusion) and external VAE latent spaces. In this paper, we propose Slot-RAE, a much simpler, fully integrated framework that operates directly within the continuous semantic feature space of visual foundation models (e.g., DINOv3). Slot-RAE employs a feature-space diffusion process using a Diffusion Transformer (DiT) decoder and a Representation Alignment (REPA) head. Unlike existing diffusion-based objectcentric methods that rely heavily on subsidized text-toimage priors, the generative core of Slot-RAE (Slot Attention and the DiT) is trained from scratch within the frozen VFM feature space. This eliminates the need for VAE bottlenecks and task-agnostic generative pre-training. Experiments on the COCO dataset demonstrate that despite its architectural simplicity, Slot-RAE achieves state-of-the-art results. It delivers comparable unsupervised object discovery, higher-fidelity image reconstruction, and robust zero-shot compositionality, all while being significantly faster and more computationally efficient than existing object-centric latent diffusion models.
Jul 7, 2026cs.CV

From RGB Generation to Dense Field Readout: Pixel-Space Dense Prediction with Text-to-Image Models

Large-scale text-to-image models are attractive backbones for dense prediction because RGB generation pretraining learns rich semantic, structural, and geometric priors. Existing generative and editing approaches reuse these priors by casting dense prediction as target generation: annotations such as depth, normals, alpha mattes, masks, and heatmaps are encoded into an RGB-trained VAE latent space and decoded back as image-like targets. We argue this inherits more of the generative output interface than dense prediction requires: unlike RGB synthesis, dense prediction asks for pixel-correct, task-native fields on the same image plane, not new RGB content to be rendered. Our key observation is that a pretrained DiT already organizes RGB inputs through a patch-to-token-to-patch lattice on the image plane, so each token indexes a fixed output patch whose channels can carry task-native quantities instead of RGB appearance. We instantiate this as ReChannel: we keep the VAE encoder for the DiT's input distribution but drop the target-side decoder, adapt the frozen DiT with task LoRA, and map each token to its p x p x K_t pixel-space patch through a shared token-local linear head--about 33K parameters, no spatial mixing. Using FLUX-Klein, we evaluate on six dense prediction tasks and over a dozen benchmarks. This minimal interface sets new state-of-the-art on trimap-free matting, KITTI depth, and referring segmentation, and stays competitive on normals, saliency, and pose. In a matched 4B setting it is more accurate and 2.48x faster than an edit-plus-latent-decode counterpart--dense perception can benefit from generative pretraining without inheriting its output interface.
Jun 30, 2026cs.CV

UniCoder: Unified Visual-to-Code Generation via Symbolic Rewards and Reference-Guided Code Optimization

Visual-to-Code generation, which transforms scientific plots, vector graphics, and webpages into executable scripts, demands a level of pixel-precise alignment that standard Multimodal Large Language Models (MLLMs) fail to achieve through Supervised Fine-Tuning (SFT) alone. While Reinforcement Learning (RL) offers a theoretical pathway to bridge this gap, its application is hindered by two fundamental obstacles: (1) \textit{Reward Coarseness}, where semantic metrics like CLIP scores fail to penalize fine-grained element deviations, and (2) \textit{Exploration Stagnation}, where the sparse, heterogeneous code search space prevents the policy from bootstrapping valid trajectories. To overcome these limitations, we introduce UniCoder, a unified RL framework that integrates two novel mechanisms. First, we propose \textbf{Symbolic Attribute Alignment}, which employs a lightweight auxiliary LLM to parse generated code into discrete visual attributes (e.g., hex colors, coordinate limits), enabling dense, element-wise reward computation. Second, to escape local optima, we devise \textbf{Reference-Guided Code Optimization}, a strategy that dynamically injects ground-truth trajectories into low-performing rollout groups, transforming blind exploration into guided policy improvement. Extensive experiments on ChartMimic, UniSVG, Design2Code and ScreenBench benchmarks demonstrate that our 8B-parameter model not only surpasses all open-source baselines but also achieves state-of-the-art performance comparable to proprietary models, establishing a new paradigm for generalized visual-to-code synthesis.
Jun 22, 2026cs.LG

DiT-Reward: Generative Representations for Text-to-Image Reward Modeling

Can representations learned for image generation also support the evaluation of generated images? We study text-to-image reward prediction as a downstream task of generative representation learning. To this end, we introduce DiT-Reward, which converts a pretrained text-to-image Diffusion Transformer into a reward model by processing near-clean image latents and aggregating text-conditioned image representations across transformer layers. Under the same training data mixture as HPSv3, DiT-Reward outperforms HPSv3 on all four evaluated preference benchmarks, reaching 85.6% on HPDv2 and 77.6% on HPDv3. When the generative backbone is frozen, a lightweight learned head can still extract meaningful preference predictions from its representations. Probing across depth further reveals that downstream reward performance is strongest in the middle-to-late layers and benefits from combining representations across different stages. We also observe consistent positive scaling with generative backbone capacity. Finally, when used to optimize Stable Diffusion 3.5 Large with Flow-GRPO, DiT-Reward outperforms HPSv3 along the matched training trajectory, with particularly clear gains in realism. Direct latent scoring also achieves a 1.65x inference speedup over HPSv3 with comparable peak memory. These results show that pretrained generative DiTs provide transferable representations for reward modeling and policy optimization.
Jun 19, 2026cs.CV

Adversarial Domain Prompt Tuning and Generation for Single Domain Generalization

Single domain generalization (SDG) aims to learn a robust model, which could perform well on many unseen domains while there is only one single domain available for training. One of the promising directions for achieving single-domain generalization is to generate out-of-domain (OOD) training data through data augmentation or image generation. Given the rapid advancements in AI-generated content (AIGC), this paper is the first to propose leveraging powerful pre-trained text-to-image (T2I) foundation models to create the training data. However, manually designing textual prompts to generate images for all possible domains is often impractical, and some domain characteristics may be too abstract to describe with words. To address these challenges, we propose a novel Progressive Adversarial Prompt Tuning (PAPT) framework for pre-trained diffusion models. Instead of relying on static textual domains, our approach learns two sets of abstract prompts as conditions for the diffusion model: one that captures domain-invariant category information and another that models domain-specific styles. This adversarial learning mechanism enables the T2I model to generate images in various domain styles while preserving key categorical features. Extensive experiments demonstrate the effectiveness of the proposed method, achieving superior performances to state-of-the-art single-domain generalization approaches.
Jun 5, 2026cs.CV

Breaking the Lock-in: Diversifying Text-to-Image Generation via Representation Modulation

Recent text-to-image models built on large-scale Transformer backbones and flow-based objectives deliver strong text-image alignment and high visual quality, yet often produce overly similar samples under a fixed prompt. Existing diversity-enhancement methods alleviate this issue, but typically require expensive sampling or auxiliary optimization, incurring non-trivial overhead. To investigate the root cause of this homogeneity, we examine intermediate Transformer features and observe that the zero-frequency spatial average (DC) component rapidly converges across seeds early in generation, causing early trajectory lock-in that limits downstream variation. Building on this observation, we propose DC Attenuation for diVersity Enhancement (DAVE), a training-free representation-level intervention that selectively attenuates this component in the early regime. DAVE preserves the sampling pipeline with negligible overhead, improving prompt-consistent diversity while maintaining competitive image quality.
Jun 4, 2026cs.LG

Balancing Image Compression and Generation with Bootstrapped Tokenization

Despite progress in image tokenization, standard methods encode redundant information by mixing all granularities within each token, thus redundancy persists between tokens. The mix of information of different granularity also complicates the training of generators. This paper introduces SelfBootTok, a method that resolves this by cleanly decomposing information into global and local token groups. Through self-bootstrapped learning, the model predicts local details exclusively from global tokens, shifting the burden of visual details from the generator to the tokenizer. Consequently, our generator is far more efficient, requiring only global tokens and reducing computation by approximately 40%, while delivering superior reconstruction and generation. Moreover, this paradigm scales elegantly: by leveraging more data or parameters to self-supervise local representation learning, SelfBootTok achieves a new state-of-the-art gFID score of 1.56 using only 64 tokens.
May 27, 2026cs.CV

GAP3D: Generative Alignment of VLM Latents to Patch-Level Embeddings for 3D Generation

Recent approaches integrating vision-language models (VLMs) as prompt encoders for generative model conditioning typically rely on expensive end-to-end training or map features to compressed representations, discarding the dense spatial structure required for geometry-aware tasks like 3D asset generation. To address this, we propose GAP3D, a modular, diffusion-based approach that aligns VLM-generated latents directly to the complete, patch-level feature space of a pre-trained image encoder, enabling a frozen downstream generative model to utilize a VLM as prompt encoder while maintaining a spatially structured conditioning signal. Evaluated on 3D asset generation, our method bypasses the need for large-scale 3D data by training mainly on general-domain image-text pairs. It also exhibits emergent zero-shot capabilities for multimodal prompts, despite being trained exclusively on text input. Finally, while currently prioritizing high-level semantics over fine-grained detail, GAP3D demonstrates that the representation gap between VLM and image-encoder feature spaces can be partially bridged through diffusion-based alignment, taking the first steps towards a modular integration of foundation models through generative alignment to dense embedding spaces.
May 25, 2026cs.CV

ERNIE-Image Technical Report

We introduce ERNIE-Image, an open-source text-to-image generation model built upon an 8B single-stream DiT architecture. ERNIE-Image aims to bridge the gap between current open-source models and leading closed-source systems through more effective mining of large-scale pre-training data and improved supervision quality throughout training. During pre-training, we adopt a bottom-up data construction pipeline that combines fine-grained image categorization, rich caption annotation, aesthetic assessment, and hierarchical sampling. This strategy reduces data noise while preserving long-tail concepts and detailed real-world knowledge, providing a stronger foundation for complex generation tasks. In the post-training stage, we use a top-down data construction pipeline for high-demand scenarios, diversify prompt annotations to better match real user inputs, and apply a stabilized DPO strategy to align the model with human aesthetic preferences. We further train ERNIE-Image-Turbo for efficient 8-NFE generation and propose MT-DMD to mitigate capability drift during distillation. To make the model easier to use in practical scenarios, we equip it with a lightweight Prompt Enhancer that expands concise user intents into structured visual descriptions. In addition, we develop ERNIE-Image-Aes, an industrial-grade aesthetic model, together with ERNIE-Image-Aes-1K, a human-annotated benchmark for realistic aesthetic evaluation. Extensive qualitative and quantitative experiments show that ERNIE-Image achieves leading performance among open-source models and approaches top-tier commercial models in instruction following, text rendering, and aesthetic quality. We release the trained models and aesthetic resources to facilitate further academic research and technical progress in the AIGC community.
May 18, 2026cs.CL

Generating Pretraining Tokens from Organic Data for Data-Bound Scaling

LLM pretraining is shifting from a compute-bound to a data-bound regime, where available human (organic) text falls far short of scaling demands. However, reaching the data-bound regime does not mean the model has fully utilized its organic corpus. In this paper, we introduce SynPro, a synthetic data generation framework that helps LLMs more thoroughly learn from limited organic data. SynPro applies two operations, rephrasing and reformat, that present the same organic source in diverse forms to facilitate deeper learning without introducing external information. Both generators are optimized via reinforcement learning with quality, faithfulness, and data influence rewards, and are continuously updated as pretraining plateaus to target content the model has yet to absorb. We pretrain 400M and 1.1B models with 10% of their Chinchilla-optimal tokens (0.8B and 2.2B) from DCLM-Baseline, reflecting a realistic data-bound regime in frontier pretraining. Our results reveal that organic data is significantly underutilized by standard repetition: SynPro unlocks 3.7-5.2x the effective tokens of repetition, even surpassing the non-data-bound oracle that trains on equivalent unique data at the 1.1B scale. Analyses confirm that faithful, model-aware synthesis sustains data-bound scaling without causing distribution collapse. We open-source our code at https://github.com/cxcscmu/SynPro.
May 15, 2026cs.LG

ITGPT: Generative Pretraining on Irregular Timeseries

Timeseries regression models often struggle to leverage large volumes of labeled multimodal data, particularly when the data are irregularly sampled or contain missing values. This is common in domains like healthcare and predictive maintenance, where data are collected from unreliable sources, and labeling requires expert knowledge or costly equipments. Transformer-based large language models have proven effective on structured data such as text through self-supervised learning (SSL) and generative pretraining (GPT) frameworks. However, such models lack the flexibility to efficiently process irregularly sampled multimodal timeseries data. In this paper, we introduce ITGPT, an attention-based architecture designed for handling multimodal, irregularly sampled timeseries by allowing training with both SSL losses and GPT-like objectives. We evaluate its performance on a healthcare task with the TIHM dataset, and a predictive maintenance task with the CompX dataset. Our results demonstrate that ITGPT achieves state-of-the-art performance without requiring resampling, feature fusion or explicit data imputation. Furthermore, when labels are scarce, ITGPT effectively leverages unlabeled data through SSL and GPT training, outperforming the purely supervised approach. This represents an important step towards efficiently using large and unstructured timeseries datasets for practical inference tasks.
May 11, 2026cs.CV

HiDream-O1-Image: A Natively Unified Image Generative Foundation Model with Pixel-level Unified Transformer

The evolution of visual generative models has long been constrained by fragmented architectures relying on disjoint text encoders and external VAEs. In this report, we present HiDream-O1-Image, a natively unified generative foundation model via pixel-space Diffusion Transformer, that pioneers a paradigm shift from modular architectures to an end-to-end in-context visual generation engine. By mapping raw image pixels, text tokens, and task-specific conditions into a single shared token space, HiDream-O1-Image achieves a structural unification of multimodal inputs within an Unified Transformer (UiT) architecture. This native encoding paradigm eliminates the need for separate VAEs or disjoint pre-trained text encoders, allowing the model to treat diverse generation and editing tasks as a consistent in-context reasoning process. Extensive experiments show that HiDream-O1-Image excels across various generation tasks, including text-to-image generation, instruction-based editing, and subject-driven personalization. Notably, with only 8B parameters, HiDream-O1-Image (8B) achieves performance parity with or even surpasses established state-of-the-art models with significantly larger parameters (e.g., 27B Qwen-Image). Crucially, to validate the immense scalability of this paradigm, we successfully scale the architecture up to over 200B parameters. Experimental results demonstrate that this massive-scale version HiDream-O1-Image-Pro (200B+) unlocks unprecedented generative capabilities and superior performance, establishing new state-of-the-art benchmarks. Ultimately, HiDream-O1-Image highlights the immense potential of natively unified architectures and charts a highly scalable path toward next-generation multimodal AI.
May 11, 2026cs.CV

Uni-Synergy: Bridging Understanding and Generation for Personalized Reasoning via Co-operative Reinforcement Learning

Unified Multimodal Models (UMMs) excel in general tasks but struggle to bridge the gap between personalized understanding and generation. Prior works largely rely on implicit token-level alignment via supervised fine-tuning, which fails to fully capture the potential synergy between comprehension and creation. In this work, we propose Sync-R1, an end-to-end reinforcement learning framework that jointly optimizes personalized understanding and generation within a single, explicit reasoning loop. Through this unified feedback process, Sync-R1 enables personalized comprehension to guide content creation, while the resulting generation quality reciprocally refines understanding within an integrated reward landscape. To efficiently orchestrate this dual-task synergy, we introduce Sync-GRPO, a reinforcement learning method utilizing an ensemble reward system. Furthermore, we propose Dynamic Group Scaling (DGS), which adaptively filters low-potential trajectories to reduce gradient variance and accelerate convergence. To better reflect real-world complexity, we introduce UnifyBench++, featuring denser textual descriptions and richer user contexts. Experimental results demonstrate that Sync-R1 achieves state-of-the-art performance, showcasing superior cross-task reasoning and robust personalization without requiring complex cold-start procedures. The code and the UnifyBench++ dataset will be released at: https://github.com/arctanxarc/UniCTokens.
May 8, 2026cs.LG

Prototype Guided Post-pretraining for Single-Cell Representation Learning

Single-cell representation learning (SCRL) from gene expression data offers a way to uncover the complex regulatory logic underlying cellular function. Inspired by large language models in natural language modeling, several single-cell pretrained models have recently been proposed that treat genes as tokens and cells as sentences. However, these models are fundamentally limited by the long-tailed nature of cell-type distributions and struggle to generalize under covariate shifts in gene expression data. While fine-tuning is often used to mitigate these issues, we observe that performance remains bounded. To address this challenge, we introduce CellRefine, a post-pretraining method that operates between the pretraining and fine-tuning stages of a single-cell foundation model. CellRefine uses a multi-faceted objective that incorporates marker-gene sets as structural priors to guide post-pretraining and refine the latent embedding manifold of cells. Across multiple computational biology tasks, empirical results show that CellRefine consistently improves downstream performance, yielding gains up to 15%.
May 1, 2026cs.CV

Let ViT Speak: Generative Language-Image Pre-training

In this paper, we present \textbf{Gen}erative \textbf{L}anguage-\textbf{I}mage \textbf{P}re-training (GenLIP), a minimalist generative pretraining framework for Vision Transformers (ViTs) designed for multimodal large language models (MLLMs). To better align vision encoders with the autoregressive nature of LLMs, GenLIP trains a ViT to predict language tokens directly from visual tokens using a standard language modeling objective, without contrastive batch construction or an additional text decoder. This design offers three key advantages: (1) \textbf{Simplicity}: a single transformer jointly models visual and textual tokens; (2) \textbf{Scalability}: it scales effectively with both data and model size; and (3) \textbf{Performance}: it achieves competitive or superior results across diverse multimodal benchmarks. Trained on 8B samples from Recap-DataComp-1B, GenLIP matches or surpasses strong baselines despite using substantially less pretraining data. After continued pretraining on multi-resolution images at native aspect ratios, GenLIP further improves on detail-sensitive tasks such as OCR and chart understanding, making it a strong foundation for vision encoders in MLLMs.
May 1, 2026cs.LG

Towards Universal Gene Regulatory Network Inference: Unlocking Generalizable Regulatory Knowledge in Single-cell Foundation Models

Gene Regulatory Network (GRN) inference is essential for understanding complex cellular mechanisms, rendered tractable through single-cell transcriptomic data. With the emergence of single-cell Foundation Models (scFMs), enhanced transcriptomic encoding is widely expected to revolutionize GRN inference. However, we observe that their performance remains far from satisfactory. The primary reason is that the standard reconstruction-based pre-training objectives often fail to explicitly capture latent regulatory signals. To bridge this gap, we first introduce a GRN generalization benchmark designed to evaluate regulatory predictions on unseen genes and datasets, which relies on the zero-shot capabilities of scFMs and is inherently challenging for traditional methods. Furthermore, to unlock the regulatory knowledge within the foundation models, we propose two novel methods, Virtual Value Perturbation and Gradient Trajectory, to distill implicit regulatory information from scFMs into highly generalizable inter-gene features. Extensive experiments demonstrate that our approach significantly outperforms existing methods, establishing a new paradigm for leveraging the potential of scFMs in universal GRN inference.
Apr 30, 2026cs.SD

Alethia: A Foundational Encoder for Voice Deepfakes

Existing voice deepfake detection and localization models rely heavily on representations extracted from speech foundation models (SFMs). However, downstream finetuning has now reached a state of diminishing returns. In this paper, we shift the focus to pretraining and propose a novel recipe that combines bottleneck masked embedding prediction with flow-matching based spectrogram reconstruction. The outcome, Alethia, is the first foundational audio encoder for various voice deepfake detection and localization tasks. We evaluate on 55 different tasks with 5656 benchmark datasets, and note Alethia significantly outperforms state-of-the-art SFMs with superior robustness to real-world perturbations and zero-shot generalization to unseen domains (e.g., singing deepfakes). We also demonstrate the limitation of discrete targets in masked token prediction, and show the importance of continuous embedding prediction and generative pretraining for capturing deepfake artifacts.
Apr 27, 2026cs.CV

ViPO: Visual Preference Optimization at Scale

While preference optimization is crucial for improving visual generative models, how to effectively scale this paradigm remains largely unexplored. Current open-source preference datasets contain conflicting preference patterns, where winners excel in some dimensions but underperform in others. Naively optimizing on such noisy datasets fails to learn preferences, hindering effective scaling. To enhance robustness against noise, we propose Poly-DPO, which extends the DPO objective with an additional polynomial term that dynamically adjusts model confidence based on dataset characteristics, enabling effective learning across diverse data distributions. Beyond biased patterns, existing datasets suffer from low resolution, limited prompt diversity, and imbalanced distributions. To facilitate large-scale visual preference optimization by tackling data bottlenecks, we construct ViPO, a massive-scale preference dataset with 1M image pairs at 1024px across five categories and 300K video pairs at 720p+ across three categories. State-of-the-art generative models and diverse prompts ensure reliable preference signals with balanced distributions. Remarkably, when applying Poly-DPO to our high-quality dataset, the optimal configuration converges to standard DPO. This convergence validates dataset quality and Poly-DPO's adaptive nature: sophisticated optimization becomes unnecessary with sufficient data quality, yet remains valuable for imperfect datasets. We validate our approach across visual generation models. On noisy datasets like Pick-a-Pic V2, Poly-DPO achieves 6.87 and 2.32 gains over Diffusion-DPO on GenEval for SD1.5 and SDXL, respectively. For ViPO, models achieve performance far exceeding those trained on existing open-source preference datasets. These results confirm that addressing both algorithmic adaptability and data quality is essential for scaling visual preference optimization.
Apr 24, 2026cs.CV

CheXmix: Unified Generative Pretraining for Vision Language Models in Medical Imaging

Recent medical multimodal foundation models are built as multimodal LLMs (MLLMs) by connecting a CLIP-pretrained vision encoder to an LLM using LLaVA-style finetuning. This two-stage, decoupled approach introduces a projection layer that can distort visual features. This is especially concerning in medical imaging where subtle cues are essential for accurate diagnoses. In contrast, early-fusion generative approaches such as Chameleon eliminate the projection bottleneck by processing image and text tokens within a single unified sequence, enabling joint representation learning that leverages the inductive priors of language models. We present CheXmix, a unified early-fusion generative model trained on a large corpus of chest X-rays paired with radiology reports. We expand on Chameleon's autoregressive framework by introducing a two-stage multimodal generative pretraining strategy that combines the representational strengths of masked autoencoders with MLLMs. The resulting models are highly flexible, supporting both discriminative and generative tasks at both coarse and fine-grained scales. Our approach outperforms well-established generative models across all masking ratios by 6.0% and surpasses CheXagent by 8.6% on AUROC at high image masking ratios on the CheXpert classification task. We further inpaint images over 51.0% better than text-only generative models and outperform CheXagent by 45% on the GREEN metric for radiology report generation. These results demonstrate that CheXmix captures fine-grained information across a broad spectrum of chest X-ray tasks. Our code is at: https://github.com/StanfordMIMI/CheXmix.
Apr 22, 2026cs.CV

Image Generators are Generalist Vision Learners

Recent works show that image and video generators exhibit zero-shot visual understanding behaviors, in a way reminiscent of how LLMs develop emergent capabilities of language understanding and reasoning from generative pretraining. While it has long been conjectured that the ability to create visual content implies an ability to understand it, there has been limited evidence that generative vision models have developed strong understanding capabilities. In this work, we demonstrate that image generation training serves a role similar to LLM pretraining, and lets models learn powerful and general visual representations that enable SOTA performance on various vision tasks. We introduce Vision Banana, a generalist model built by instruction-tuning Nano Banana Pro (NBP) on a mixture of its original training data alongside a small amount of vision task data. By parameterizing the output space of vision tasks as RGB images, we seamlessly reframe perception as image generation. Our generalist model, Vision Banana, achieves SOTA results on a variety of vision tasks involving both 2D and 3D understanding, beating or rivaling zero-shot domain-specialists, including Segment Anything Model 3 on segmentation tasks, and the Depth Anything series on metric depth estimation. We show that these results can be achieved with lightweight instruction-tuning without sacrificing the base model's image generation capabilities. The superior results suggest that image generation pretraining is a generalist vision learner. It also shows that image generation serves as a unified and universal interface for vision tasks, similar to text generation's role in language understanding and reasoning. We could be witnessing a major paradigm shift for computer vision, where generative vision pretraining takes a central role in building Foundational Vision Models for both generation and understanding.
Apr 21, 2026cs.RO

Mask World Model: Predicting What Matters for Robust Robot Policy Learning

World models derived from large-scale video generative pre-training have emerged as a promising paradigm for generalist robot policy learning. However, standard approaches often focus on high-fidelity RGB video prediction, this can result in overfitting to irrelevant factors, such as dynamic backgrounds and illumination changes. These distractions reduce the model's ability to generalize, ultimately leading to unreliable and fragile control policies. To address this, we introduce the Mask World Model (MWM), which leverages video diffusion architectures to predict the evolution of semantic masks instead of pixels. This shift imposes a geometric information bottleneck, forcing the model to capture essential physical dynamics and contact relations while filtering out visual noise. We seamlessly integrate this mask dynamics backbone with a diffusion-based policy head to enable robust end-to-end control. Extensive evaluations demonstrate the superiority of MWM on the LIBERO and RLBench simulation benchmarks, significantly outperforming the state-of-the-art RGB-based world models. Furthermore, real-world experiments and robustness evaluation (via random token pruning) reveal that MWM exhibits superior generalization capabilities and robust resilience to texture information loss.
Apr 21, 2026cs.CV

Generative Texture Filtering

We present a generative method for texture filtering, which exhibits surprisingly good performance and generalizability. Our core idea is to empower texture filtering by taking full advantage of the strong learned image prior of pre-trained generative models. To this end, we propose to fine-tune a pre-trained generative model via a two-stage strategy. Specifically, we first conduct supervised fine-tuning on a very small set of paired images, and then perform reinforcement fine-tuning on a large-scale unlabeled dataset under the guidance of a reward function that quantifies the quality of texture removal and structure preservation. Extensive experiments show that our method clearly outperforms previous methods, and is effective to deal with previously challenging cases. Our code is available at https://github.com/OnlyZZZZ/Generative_Texture_Filtering.
Apr 16, 2026cs.AI

Intermediate Layers Encode Optimal Biological Representations in Single-Cell Foundation Models

Current single-cell foundation model benchmarks universally extract final layer embeddings, assuming these represent optimal feature spaces. We systematically evaluate layer-wise representations from scFoundation (100M parameters) and Tahoe-X1 (1.3B parameters) across trajectory inference and perturbation response prediction. Our analysis reveals that optimal layers are task-dependent (trajectory peaks at 60% depth, 31% above final layers) and context-dependent (perturbation optima shift 0-96% across T cell activation states). Notably, first-layer embeddings outperform all deeper layers in quiescent cells, challenging assumptions about hierarchical feature abstraction. These findings demonstrate that "where" to extract features matters as much as "what" the model learns, necessitating systematic layer evaluation tailored to biological task and cellular context rather than defaulting to final-layer embeddings.
Nov 27, 2025cs.CV

Z-Image: An Efficient Image Generation Foundation Model with Single-Stream Diffusion Transformer

The landscape of high-performance image generation models is currently dominated by proprietary systems, such as Nano Banana Pro and Seedream 4.0. Leading open-source alternatives, including Qwen-Image, Hunyuan-Image-3.0 and FLUX.2, are characterized by massive parameter counts (20B to 80B), making them impractical for inference, and fine-tuning on consumer-grade hardware. To address this gap, we propose Z-Image, an efficient 6B-parameter foundation generative model built upon a Scalable Single-Stream Diffusion Transformer (S3-DiT) architecture that challenges the "scale-at-all-costs" paradigm. By systematically optimizing the entire model lifecycle -- from a curated data infrastructure to a streamlined training curriculum -- we complete the full training workflow in just 314K H800 GPU hours (approx. $630K). Our few-step distillation scheme with reward post-training further yields Z-Image-Turbo, offering both sub-second inference latency on an enterprise-grade H800 GPU and compatibility with consumer-grade hardware (<16GB VRAM). Additionally, our omni-pre-training paradigm also enables efficient training of Z-Image-Edit, an editing model with impressive instruction-following capabilities. Both qualitative and quantitative experiments demonstrate that our model achieves performance comparable to or surpassing that of leading competitors across various dimensions. Most notably, Z-Image exhibits exceptional capabilities in photorealistic image generation and bilingual text rendering, delivering results that rival top-tier commercial models, thereby demonstrating that state-of-the-art results are achievable with significantly reduced computational overhead. We publicly release our code, weights, and online demo to foster the development of accessible, budget-friendly, yet state-of-the-art generative models.
Oct 1, 2025cs.CL

Verbalized Sampling: How to Mitigate Mode Collapse and Unlock LLM Diversity

Post-training alignment often reduces LLM diversity, leading to a phenomenon known as mode collapse. Unlike prior work that attributes this effect to algorithmic limitations, we identify a fundamental, pervasive data-level driver: typicality bias in preference data, whereby annotators systematically favor familiar text as a result of well-established findings in cognitive psychology. We formalize this bias theoretically, verify it on preference datasets empirically, and show that it plays a central role in mode collapse. Motivated by this analysis, we introduce Verbalized Sampling, a simple, training-free prompting strategy to circumvent mode collapse. VS prompts the model to verbalize a probability distribution over a set of responses (e.g., "Generate 5 jokes about coffee and their corresponding probabilities"). Comprehensive experiments show that VS significantly improves performance across creative writing (poems, stories, jokes), dialogue simulation, open-ended QA, and synthetic data generation, without sacrificing factual accuracy and safety. For instance, in creative writing, VS increases diversity by 1.6-2.1x over direct prompting. We further observe an emergent trend that more capable models benefit more from VS. In sum, our work provides a new data-centric perspective on mode collapse and a practical inference-time remedy that helps unlock pre-trained generative diversity.