Design of a Robot-Assisted Chemical Dialysis System

Open-source social robots offer accessibility, repairability, and student empowerment, yet the build itself often presents a barrier. Existing platforms either ship pre-assembled, foreclosing hands-on learning, or expose students to unfamiliar fasteners, opaque wiring, and inaccessible service points that erode engagement. Whether targeted mechanical redesign can lower this barrier whilst maintaining structural integrity remains untested. Here we show that Design for Assembly (DfA) and Design for Disassembly (DfD) interventions reshape how a build feels before they shorten how long it takes. Working with university students in Guyana and Estonia, we applied the Double Diamond framework to co-create the Robot Study Companion (RSC) v4.1: mapping pain points, then redesigning its chassis around twist-lock fasteners, snap-fit joints, and tool-free service latches. Across two studies with developers and first-time builders, system usability climbed from Poor to Excellent (SUS 59.4 to 89.4), perceived workload trended downward (NASA-TLX 4.29 to 4.00), and mean assembly time trended downward (21.4 to 13.7 minutes, with juniors' learning effect), whilst orientation cues and navigation continuity for first-time builders emerged as the next documentation frontier. Perceived workload, not completion time, appears to govern whether students take up open hardware.

Laboratory automation accelerates discovery, yet its adoption is constrained by the high cost, proprietary design, and limited remote supervisability of commercial liquid-handling systems. This work presents RAINBOT\textsuperscript{TM}, a low-cost, openly reproducible liquid-handling robot built by converting a consumer-grade Cartesian 3D printer (Elegoo Neptune 4 Max). The printer extruder is replaced by a precision single-channel pipette actuated through the printer's own G-code-driven X--Y--Z gantry, with plunger and tip-eject motions effected by two compact linear actuators under Python control. To make experiments transparent and remotely supervisable, a browser-based digital twin is implemented to synchronise bidirectionally with the physical platform, mirroring kinematics and pipetting states in real time and exposing remote monitoring, intervention, and an emergency stop from any web browser. As a proof of concept, RAINBOT\textsuperscript{TM} performed sequential exchanges of differently coloured aqueous solutions while an integrated colour sensor quantified the resulting mixtures; measured red, yellow, and blue (RYB) responses agreed with expected mixing behaviour to within a mean absolute error of two percentage points, validating correct execution and real-time tracking. Closing the loop, the platform is coupled to the CEID\textsuperscript{TM} (Cooperative Explorer for Inverse Design) framework, which recasts experimentation from iterative manual guessing into a goal-directed inverse-design search while keeping a human in the loop. The complete hardware costs under US$1300, which is roughly an order of magnitude below entry-level commercial handlers, thereby establishing an accessible physical--virtual framework for self-driving laboratory automation.

AI is evaluated through knowledge, reasoning and plan generation, yet scientific agency requires reliable physical action and adaptation to evidence. Here, we use a robotic chemistry laboratory as a physical-world testbed to make scientific agency measurable. Its 45 modular workstations exposed as machine-readable skills enabled 4,608 trials. Only 3.3% of trials produced expert-assessed executable workflows under laboratory constraints; even the best system achieved 28.1%. Long-horizon planning remained a challenge: only three executable workflows exceeded 30 operations, although the longest contained 44. Across five rounds, experimental feedback prompted local adjustments but no workflow-level replanning or analytical-method redesign. By making physical executability and evidence-driven replanning measurable, our study provides an evidence-based assessment of deployment readiness and a diagnostic framework to guide closed-loop improvements towards physically grounded autonomous research.