Overview

Classification studies how to assign inputs such as images, text, signals, graphs, and tabular records to discrete categories, supporting decisions across science and everyday systems. Methods range from linear and kernel discriminants, trees and ensembles, and deep neural networks to pretrained language and vision models, using supervised, few-shot, semi-supervised, and in-context learning. Current work also addresses class imbalance, label noise, distribution shift, open-set recognition, calibration, abstention, and structured labels through robust losses, uncertainty estimates, retrieval, and hierarchical or multimodal models. A central tension is that high benchmark accuracy can conceal shortcut reliance, poor calibration, subgroup failures, or weak transfer, so evaluation increasingly tests reliability, error costs, and performance under deployment shifts.

Latest papers

413 papers54 papers in the last four weeks, down 4% on the four weeks before. 0.3% of all new papers.

Mar 27, 2026

DuSCN-FusionNet: An Interpretable Dual-Channel Structural Covariance Fusion Framework for ADHD Classification Using Structural MRI

Attention Deficit Hyperactivity Disorder (ADHD) is a highly prevalent neurodevelopmental condition; however, its neurobiological diagnosis remains challenging due to the lack of reliable imaging-based biomarkers, particularly anatomical markers. Structural MRI (sMRI) provides a non-invasive modality for investigating brain alterations associated with ADHD; nevertheless, most deep learning approaches function as black-box systems, limiting clinical trust and interpretability. In this work, we propose DuSCN-FusionNet, an interpretable sMRI-based framework for ADHD classification that leverages dual-channel Structural Covariance Networks (SCNs) to capture inter-regional morphological relationships. ROI-wise mean intensity and intra-regional variability descriptors are used to construct intensity-based and heterogeneity-based SCNs, which are processed through an SCN-CNN encoder. In parallel, auxiliary ROI-wise variability features and global statistical descriptors are integrated via late-stage fusion to enhance performance. The model is evaluated using stratified 10-fold cross-validation with a 5-seed ensemble strategy, achieving a mean balanced accuracy of 80.59% and an AUC of 0.778 on the Peking University site of the ADHD-200 dataset. DuSCN-FusionNet further achieves precision, recall, and F1-scores of 81.66%, 80.59%, and 80.27%, respectively. Moreover, Grad-CAM is adapted to the SCN domain to derive ROI-level importance scores, enabling the identification of structurally relevant brain regions as potential biomarkers.
Mar 27, 2026

D-GATNet: Interpretable Temporal Graph Attention Learning for ADHD Identification Using Dynamic Functional Connectivity

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder whose neuroimaging-based diagnosis remains challenging due to complex time-varying disruptions in brain connectivity. Functional MRI (fMRI) provides a powerful non-invasive modality for identifying functional alterations. Existing deep learning (DL) studies employ diverse neuroimaging features; however, static functional connectivity remains widely used, whereas dynamic connectivity modeling is comparatively underexplored. Moreover, many DL models lack interpretability. In this work, we propose D-GATNet, an interpretable temporal graph-based framework for automated ADHD classification using dynamic functional connectivity (dFC). Sliding-window Pearson correlation constructs sequences of functional brain graphs with regions of interest as nodes and connectivity strengths as edges. Spatial dependencies are learned via a multi-layer Graph Attention Network, while temporal dynamics are modeled using 1D convolution followed by temporal attention. Interpretability is achieved through graph attention weights revealing dominant ROI interactions, ROI importance scores identifying influential regions, and temporal attention emphasizing informative connectivity segments. Experiments on the Peking University site of the ADHD-200 dataset using stratified 10-fold cross-validation with a 5-seed ensemble achieved 85.18% +_5.64 balanced accuracy and 0.881 AUC, outperforming state-of-the-art methods. Attention analysis reveals cerebellar and default mode network disruptions, indicating potential neuroimaging biomarkers.
Mar 26, 2026

Evaluating Synthetic Images as Effective Substitutes for Experimental Data in Surface Roughness Classification

Hard coatings play a critical role in industry, with ceramic materials offering outstanding hardness and thermal stability for applications that demand superior mechanical performance. However, deploying artificial intelligence (AI) for surface roughness classification is often constrained by the need for large labeled datasets and costly high-resolution imaging equipment. In this study, we explore the use of synthetic images, generated with Stable Diffusion XL, as an efficient alternative or supplement to experimentally acquired data for classifying ceramic surface roughness. We show that augmenting authentic datasets with generative images yields test accuracies comparable to those obtained using exclusively experimental images, demonstrating that synthetic images effectively reproduce the structural features necessary for classification. We further assess method robustness by systematically varying key training hyperparameters (epoch count, batch size, and learning rate), and identify configurations that preserve performance while reducing data requirements. Our results indicate that generative AI can substantially improve data efficiency and reliability in materials-image classification workflows, offering a practical route to lower experimental cost, accelerate model development, and expand AI applicability in materials engineering.
Mar 26, 2026

Decoding Market Emotions in Cryptocurrency Tweets via Predictive Statement Classification with Machine Learning and Transformers

The growing prominence of cryptocurrencies has triggered widespread public engagement and increased speculative activity, particularly on social media platforms. This study introduces a novel classification framework for identifying predictive statements in cryptocurrency-related tweets, focusing on five popular cryptocurrencies: Cardano, Matic, Binance, Ripple, and Fantom. The classification process is divided into two stages: Task 1 involves binary classification to distinguish between Predictive and Non-Predictive statements. Tweets identified as Predictive proceed to Task 2, where they are further categorized as Incremental, Decremental, or Neutral. To build a robust dataset, we combined manual and GPT-based annotation methods and utilized SenticNet to extract emotion features corresponding to each prediction category. To address class imbalance, GPT-generated paraphrasing was employed for data augmentation. We evaluated a wide range of machine learning, deep learning, and transformer-based models across both tasks. The results show that GPT-based balancing significantly enhanced model performance, with transformer models achieving the highest F1-score in Task 1, while traditional machine learning models performed best in Task 2. Furthermore, our emotion analysis revealed distinct emotional patterns associated with each prediction category across the different cryptocurrencies.
Mar 25, 2026

Enhancing Structured Meaning Representations with Aspect Classification

To fully capture the meaning of a sentence, semantic representations should encode aspect, which describes the internal temporal structure of events. In graph-based meaning representation frameworks such as Uniform Meaning Representations (UMR), aspect lets one know how events unfold over time, including distinctions such as states, activities, and completed events. Despite its importance, aspect remains sparsely annotated across semantic meaning representation frameworks. This has, in turn, hindered not only current manual annotation, but also the development of automatic systems capable of predicting aspectual information. In this paper, we introduce a new dataset of English sentences annotated with UMR aspect labels over Abstract Meaning Representation (AMR) graphs that lack the feature. We describe the annotation scheme and guidelines used to label eventive predicates according to the UMR aspect lattice, as well as the annotation pipeline used to ensure consistency and quality across annotators through a multi-step adjudication process. To demonstrate the utility of our dataset for future automation, we present baseline experiments using three modeling approaches. Our results establish initial benchmarks for automatic UMR aspect prediction and provide a foundation for integrating aspect into semantic meaning representations more broadly.
Mar 24, 2026

Robustness Quantification for Discriminative Models: a New Robustness Metric and its Application to Dynamic Classifier Selection

Among the different possible strategies for evaluating the reliability of individual predictions of classifiers, robustness quantification stands out as a method that evaluates how much uncertainty a classifier could cope with before changing its prediction. However, its applicability is more limited than some of its alternatives, since it requires the use of generative models and restricts the analyses either to specific model architectures or discrete features. In this work, we propose a new robustness metric applicable to any probabilistic discriminative classifier and any type of features. We demonstrate that this new metric is capable of distinguishing between reliable and unreliable predictions, and use this observation to develop new strategies for dynamic classifier selection.
Mar 24, 2026

Physical Knot Classification Beyond Accuracy: A Benchmark and Diagnostic Study

Physical knot classification is a challenging fine-grained recognition task in which the intended discriminative cue is rope crossing structure; however, high closed-set accuracy may still arise from low-level appearance shortcuts rather than genuine topological understanding. In this work, we introduce dataset (1,440 images, 10 classes), which trains models on loosely tied knots and evaluates them on tightly dressed configurations to probe whether structure-guided training yields topology-specific gains. We demonstrate that topological distance successfully predicts residual inter-class confusion across multiple backbone architectures, validating the utility of our topology-aware evaluation framework. Furthermore, we propose topology-aware centroid alignment (TACA) and an auxiliary crossing-number prediction objective as two complementary forms of structural supervision. Notably, Swin-T with TACA achieves a consistent positive specificity gain (Delta_spec = +1.18 pp) across all random seeds under the canonical protocol, and auxiliary crossing-number prediction exhibits robust performance across data regimes without the real-versus-random reversal observed for centroid alignment. Causal probes reveal that background changes alone flip 17-32% of predictions and phone-photo accuracy drops by 58-69 percentage points, underscoring that appearance bias remains the principal obstacle to deployment. These results collectively demonstrate that our diagnostic workflow provides a principled and practical tool for evaluating whether a hand-crafted structural prior delivers genuine task-relevant benefit beyond generic regularization.
Mar 24, 2026

Where Experts Disagree, Models Fail: Detecting Implicit Legal Citations in French Court Decisions

Applying computational methods to law at scale requires separating genuine legal reasoning from surface similarity. We study this through a concrete task: detecting implicit citations of the French Civil Code, where a court applies a statutory rule without naming it (a post-hoc question about the reasoning a court actually used). We release a benchmark of 1,015 passage-article pairs annotated by three legal experts. Our central finding is that their disagreement is itself informative: the third of cases the experts dispute are where models fail. Our best ensemble reaches an F1 score of 0.70 overall. Yet, two-thirds of its false positives fall on those disputed cases, a concentration that holds across all ten models we evaluate. Expert disagreement thus signals uncertainty in the task and in its gold label, which aggregate metrics hide. This should not block useful tools, however: reframed as top-kk ranking with multi-model consensus, the same signals reach 76% precision for the top-200 candidates of the benchmark without supervision.
Mar 23, 2026

Computationally lightweight classifiers with frequentist bounds on predictions

While both classical and neural network classifiers can achieve high accuracy, they fall short on offering uncertainty bounds on their predictions, making them unfit for safety-critical applications. Existing kernel-based classifiers that provide such bounds scale with O(n∼3)\mathcal O (n^{\sim3}) in time, making them computationally intractable for large datasets. To address this, we propose a novel, computationally efficient classification algorithm based on the Nadaraya-Watson estimator, for whose estimates we derive frequentist uncertainty intervals. We evaluate our classifier on synthetically generated data and on electrocardiographic heartbeat signals from the MIT-BIH Arrhythmia database. We show that the method achieves competitive accuracy >>\SI{96}{\percent} at O(n)\mathcal O(n) and O(log⁡n)\mathcal O(\log n) operations, while providing actionable uncertainty bounds. These bounds can, e.g., aid in flagging low-confidence predictions, making them suitable for real-time settings with resource constraints, such as diagnostic monitoring or implantable devices.
Mar 22, 2026

A Large-Scale Remote Sensing Dataset and VLM-based Algorithm for Fine-Grained Road Hierarchy Classification

In this work, we present SYSU-HiRoads, a large-scale hierarchical road dataset, and RoadReasoner, a vision-language-geometry framework for automatic multi-grade road mapping from remote sensing imagery. SYSU-HiRoads is built from GF-2 imagery covering 3631 km2 in Henan Province, China, and contains 1079 image tiles at 0.8 m spatial resolution. Each tile is annotated with dense road masks, vectorized centerlines, and three-level hierarchy labels, enabling the joint training and evaluation of segmentation, topology reconstruction, and hierarchy classification. Building on this dataset, RoadReasoner is designed to generate robust road surface masks, topology-preserving road networks, and semantically coherent hierarchy assignments. We strengthen road feature representation and network connectivity by explicitly enhancing frequency-sensitive cues and multi-scale context. Moreover, we perform hierarchy inference at the skeleton-segment level with geometric descriptors and geometry-aware textual prompts, queried by vision-language models to obtain linguistically interpretable grade decisions. Experiments on SYSU-HiRoads and the CHN6-CUG dataset show that RoadReasoner surpasses state-of-the-art road extraction baselines and produces accurate and semantically consistent road hierarchy maps with 72.6% OA, 64.2% F1 score, and 60.6% SegAcc. The dataset and code will be publicly released to support automated transport infrastructure mapping, road inventory updating, and broader infrastructure management applications.
Mar 21, 2026

Exponential Family Discriminant Analysis: Generalizing LDA-Style Generative Classification to Non-Gaussian Models

We introduce Exponential Family Discriminant Analysis (EFDA), a unified generative framework that extends classical Linear Discriminant Analysis (LDA) beyond the Gaussian setting to any member of the exponential family. Under the assumption that each class-conditional density belongs to a common exponential family, EFDA derives closed-form maximum-likelihood estimators for all natural parameters and yields a decision rule that is linear in the sufficient statistic, recovering LDA as a special case and capturing nonlinear decision boundaries in the original feature space. We prove that EFDA is asymptotically calibrated and statistically efficient under correct specification, and we generalise it to K≥2K \geq 2 classes and multivariate data. Through extensive simulation across five exponential-family distributions (Weibull, Gamma, Exponential, Poisson, Negative Binomial), EFDA matches the classification accuracy of LDA, QDA, and logistic regression while reducing Expected Calibration Error (ECE) by 22-6×6\times, a gap that is structural: it persists for all nn and across all class-imbalance levels, because misspecified models remain asymptotically miscalibrated. We further prove and empirically confirm that EFDA's log-odds estimator approaches the Cramér-Rao bound under correct specification, and is the only estimator in our comparison whose mean squared error converges to zero. Complete derivations are provided for nine distributions. Finally, we formally verify all four theoretical propositions in Lean 4, using Aristotle (Harmonic) and OpenGauss (Math, Inc.) as proof generators, with all outputs independently machine-checked by AXLE (Axiom).
Mar 20, 2026

Binary Classification from Coupled Pairwise Labels

Even when it is difficult to assign absolute class labels to individual instances, relational information may still be available, such as whether two instances belong to the same class or which instance is more likely to belong to the positive class. In this study, we refer to these two types of information as Similarity/Dissimilarity (SD) labels and Pairwise Comparison (Pcomp) labels, respectively, and consider binary classification that uses both types of relational information from the same instance pairs. SD learning uses the distinction between similar and dissimilar pairs but does not use the ordering within each pair, whereas Pcomp learning uses the ordering within each pair but does not distinguish between similar and dissimilar pairs. We therefore propose SD-Pcomp learning, whose objective function simultaneously preserves the structures of both SD learning and Pcomp learning. The proposed objective function admits two decompositions: one consists of an SD estimator plus a term that represents ordering information from Pcomp labels, and the other consists of a Pcomp estimator plus a term that represents pair-type information from SD labels. These decompositions clarify how the complementary information provided by SD and Pcomp labels is integrated into the proposed objective function. Experiments on eight datasets compare the proposed method with SD learning, Pcomp learning, and a method that takes a convex combination of their objective functions. We evaluate the effect of using both types of relational information on classification performance in terms of classification accuracy and AUC.
Mar 20, 2026

Smartphone-Based Identification of Unknown Liquids via Active Vibration Sensing

Traditional liquid identification instruments are often unavailable to the general public. This paper shows the feasibility of identifying unknown liquids with commercial lightweight devices, such as a smartphone. The key insight is that different liquid molecules have different viscosity coefficients and therefore must overcome different energy barriers during relative motion. With this intuition in mind, we introduce a novel model that measures liquids' viscosity based on active vibration. However, building a robust system using built-in smartphone accelerometers is challenging. Practical issues include under-sampling, self-interference, and the impact of liquid-volume changes. Instead of machine learning, we tackle these issues through multiple signal processing stages to reconstruct the original signals and cancel out the interference. Our approach estimates liquid viscosity with a mean relative error of 2.9% and distinguishes 30 types of liquids with an average accuracy of 95.47%.
Mar 19, 2026

Interpretable liquid crystal phase classification via two-by-two ordinal patterns

Liquid crystal textures encode rich structural information, yet mapping these images to mesophase identity remains challenging because visually similar patterns can arise from distinct structures. Here we present a simple, interpretable representation that maps textures to a 75-dimensional frequency vector of two-by-two ordinal patterns, grouped into eleven symmetry-based types to characterize a large-scale dataset spanning seven mesophases. Combined with a simple machine learning classifier, this lightweight representation yields near-perfect phase recognition, including the difficult distinction between smectic A and smectic B mesophases. Our approach generalizes to unseen compounds and accurately distinguishes between phase identity and material origin. Unlike deep learning methods, each ordinal pattern is readily interpretable, and model explanations augmented with network visualizations of pattern interactions reveal the specific types and pairwise dependencies that drive each mesophase decision, providing compact, physically meaningful summaries of texture determinants. These results establish two-by-two ordinal patterns as an interpretable and scalable tool for liquid crystal image analysis, with potential applications to other complex patterned systems in materials science.
Mar 19, 2026

Hardness of High-Dimensional Linear Classification

We establish new exponential in dimension lower bounds for the Maximum Halfspace Discrepancy problem, which models linear classification. Both are fundamental problems in computational geometry and machine learning in their exact and approximate forms. However, only O(nd)O(n^d) and respectively O~(1/εd)\tilde O(1/\varepsilon^d) upper bounds are known and complemented by polynomial lower bounds that do not support the exponential in dimension dependence. We close this gap up to polylogarithmic terms by reduction from widely-believed hardness conjectures for Affine Degeneracy testing and kk-Sum problems. Our reductions yield matching lower bounds of Ω~(nd)\tildeΩ(n^d) and respectively Ω~(1/εd)\tildeΩ(1/\varepsilon^d) based on Affine Degeneracy testing, and Ω~(nd/2)\tildeΩ(n^{d/2}) and respectively Ω~(1/εd/2)\tildeΩ(1/\varepsilon^{d/2}) conditioned on kk-Sum. The first bound also holds unconditionally if the computational model is restricted to make sidedness queries, which corresponds to a widely spread setting implemented and optimized in many contemporary algorithms and computing paradigms.
Mar 19, 2026

Cross-Modal Rationale Transfer for Explainable Humanitarian Classification on Social Media

Advances in social media data dissemination enable the provision of real-time information during a crisis. The information comes from different classes, such as infrastructure damages, persons missing or stranded in the affected zone, etc. Existing methods attempted to classify text and images into various humanitarian categories, but their decision-making process remains largely opaque, which affects their deployment in real-life applications. Recent work has sought to improve transparency by extracting textual rationales from tweets to explain predicted classes. However, such explainable classification methods have mostly focused on text, rather than crisis-related images. In this paper, we propose an interpretable-by-design multimodal classification framework. Our method first learns the joint representation of text and image using a visual language transformer model and extracts text rationales. Next, it extracts the image rationales via the mapping with text rationales. Our approach demonstrates how to learn rationales in one modality from another through cross-modal rationale transfer, which saves annotation effort. Finally, tweets are classified based on extracted rationales. Experiments are conducted over CrisisMMD benchmark dataset, and results show that our proposed method boosts the classification Macro-F1 by 2-35% while extracting accurate text tokens and image patches as rationales. Human evaluation also supports the claim that our proposed method is able to retrieve better image rationale patches (12%) that help to identify humanitarian classes. Our method adapts well to new, unseen datasets in zero-shot mode, achieving an accuracy of 80%.
Mar 16, 2026

Enhancing classification accuracy through chaos

We propose a novel approach which exploits chaos to enhance classification accuracy. Specifically, the available data that need to be classified are treated as vectors that are first lifted into a higher-dimensional space and then used as initial conditions for the evolution of a chaotic dynamical system for a prescribed temporal interval. The evolved state of the dynamical system is then fed to a trainable softmax classifier which outputs the probabilities of the various classes. As proof-of-concept, we use samples of randomly perturbed orthogonal vectors of moderate dimension (2 to 20), with a corresponding number of classes equal to the vector dimension, and show how our approach can both significantly accelerate the training process and improve the classification accuracy compared to a standard softmax classifier which operates on the original vectors, as well as a softmax classifier which only lifts the vectors to a higher-dimensional space without evolving them. We also provide an explanation for the improved performance of the chaos-enhanced classifier and a selection process for the optimal chaotic evolution interval.
Mar 16, 2026

Fine-tuning RoBERTa for CVE-to-CWE Classification: A 125M Parameter Model Competitive with LLMs

We present a fine-tuned RoBERTa-base classifier (125M parameters) for mapping Common Vulnerabilities and Exposures (CVE) descriptions to Common Weakness Enumeration (CWE) categories. We construct a large-scale training dataset of 234,770 CVE descriptions with AI-refined CWE labels using Claude Sonnet 4.6, and agreement-filtered evaluation sets where NVD and AI labels agree. On our held-out test set (27,780 samples, 205 CWE classes), the model achieves 87.4% top-1 accuracy and 60.7% Macro F1 -- a +15.5 percentage-point Macro F1 gain over a TF-IDF baseline that already reaches 84.9% top-1, demonstrating the model's advantage on rare weakness categories. On the external CTI-Bench benchmark (NeurIPS 2024), the model achieves 75.6% strict accuracy (95% CI: 72.8-78.2%) -- statistically indistinguishable from Cisco Foundation-Sec-8B-Reasoning (75.3%, 8B parameters) at 64x fewer parameters. We release the dataset, model, and training code.
Mar 13, 2026

SortScrews: A Dataset and Baseline for Real-time Screw Classification

Automatic identification of screw types is important for industrial automation, robotics, and inventory management. However, publicly available datasets for screw classification are scarce, particularly for controlled single-object scenarios commonly encountered in automated sorting systems. In this work, we introduce SortScrews\textbf{SortScrews}, a dataset for casewise visual classification of screws. The dataset contains 560 RGB images at 512×512512\times512 resolution covering six screw types and a background class. Images are captured using a standardized acquisition setup and include mild variations in lighting and camera perspective across four capture settings. To facilitate reproducible research and dataset expansion, we also provide a reusable data collection script that allows users to easily construct similar datasets for custom hardware components using inexpensive camera setups. We establish baseline results using transfer learning with EfficientNet-B0 and ResNet-18 classifiers pretrained on ImageNet. In addition, we conduct a well-explored failure analysis. Despite the limited dataset size, these lightweight models achieve strong classification accuracy, demonstrating that controlled acquisition conditions enable effective learning even with relatively small datasets. The dataset, collection pipeline, and baseline training code are publicly available at https://github.com/ATATC/SortScrews.
Mar 13, 2026

Wear Classification of Abrasive Flap Wheels using a Hierarchical Deep Learning Approach

Abrasive flap wheels are common for finishing complex free-form surfaces due to their flexibility. However, this flexibility results in complex wear patterns such as concave/convex flap profiles or flap tears, which influence the grinding result. This paper proposes a novel, vision-based hierarchical classification framework to automate the wear condition monitoring of flap wheels. Unlike monolithic classification approaches, we decompose the problem into three logical levels: (1) state detection (new vs. worn), (2) wear type identification (rectangular, concave, convex) and flap tear detection, and (3) severity assessment (partial vs. complete deformation). A custom-built dataset of real flap wheel images was generated and a transfer learning approach with EfficientNetV2 architecture was used. The results demonstrate high robustness with classification accuracies ranging from 93.8% (flap tears) to 99.3% (concave severity). Furthermore, Gradient-weighted Class Activation Mapping (Grad-CAM) is utilized to validate that the models learn physically relevant features and examine false classifications. The proposed hierarchical method provides a basis for adaptive process control and wear consideration in automated flap wheel grinding.
Mar 13, 2026

Deep Learning Based Estimation of Blood Glucose Levels from Multidirectional Scleral Blood Vessel Imaging

Regular monitoring of glycemic status is essential for diabetes management, yet conventional blood-based testing can be burdensome for frequent assessment. The sclera contains superficial microvasculature that may exhibit diabetes related alterations and is readily visible on the ocular surface. We propose ScleraGluNet, a multiview deep-learning framework for three-class metabolic status classification (normal, controlled diabetes, and high-glucose diabetes) and continuous fasting plasma glucose (FPG) estimation from multidirectional scleral vessel images. The dataset comprised 445 participants (150/140/155) and 2,225 anterior-segment images acquired from five gaze directions per participant. After vascular enhancement, features were extracted using parallel convolutional branches, refined with Manta Ray Foraging Optimization (MRFO), and fused via transformer-based cross-view attention. Performance was evaluated using subject-wise five-fold cross-validation, with all images from each participant assigned to the same fold. ScleraGluNet achieved 93.8% overall accuracy, with one-vs-rest AUCs of 0.971,0.956, and 0.982 for normal, controlled diabetes, and high-glucose diabetes, respectively. For FPG estimation, the model achieved MAE = 6.42 mg/dL and RMSE = 7.91 mg/dL, with strong correlation to laboratory measurements (r = 0.983; R2 = 0.966). Bland Altman analysis showed a mean bias of +1.45 mg/dL with 95% limits of agreement from -8.33 to +11.23$ mg/dL. These results support multidirectional scleral vessel imaging with multiview learning as a promising noninvasive approach for glycemic assessment, warranting multicenter validation before clinical deployment.
Mar 12, 2026

Chemical Reaction Networks Learn Better than Spiking Neural Networks

We mathematically prove that chemical reaction networks without hidden layers can solve tasks for which spiking neural networks require hidden layers. Our proof uses the deterministic mass-action kinetics formulation of chemical reaction networks. Specifically, we prove that a certain reaction network without hidden layers can learn a classification task previously proved to be achievable by a spiking neural network with hidden layers. We provide analytical regret bounds for the global behavior of the network and analyze its asymptotic behavior and Vapnik-Chervonenkis dimension. In a numerical experiment, we confirm the learning capacity of the proposed chemical reaction network for classifying handwritten digits in pixel images, and we show that it solves the task more accurately and efficiently than a spiking neural network with hidden layers. This provides a motivation for machine learning in chemical computers and a mathematical explanation for how biological cells might exhibit more efficient learning behavior within biochemical reaction networks than neuronal networks.
Mar 12, 2026

Multimodal classification of Radiation-Induced Contrast Enhancements and tumor recurrence using deep learning

The differentiation between tumor recurrence and radiation-induced contrast enhancements in post-treatment glioblastoma patients remains a major clinical challenge. Existing approaches rely on clinically sparsely available diffusion MRI or do not consider radiation maps, which are gaining increasing interest in the tumor board for this differentiation. We introduce RICE-NET, a multimodal 3D deep learning model that integrates longitudinal MRI data with radiotherapy dose distributions for automated lesion classification using conventional T1-weighted MRI data. Using a cohort of 92 patients, the model achieved an F1 score of 0.92 on an independent test set. During extensive ablation experiments, we quantified the contribution of each timepoint and modality and showed that reliable classification largely depends on the radiation map. Occlusion-based interpretability analyses further confirmed the model's focus on clinically relevant regions. These findings highlight the potential of multimodal deep learning to enhance diagnostic accuracy and support clinical decision-making in neuro-oncology.
Mar 12, 2026

Large Language Models for Biomedical Article Classification

This work presents a systematic and in-depth investigation of the utility of large language models as text classifiers for biomedical article classification. The study uses several small and mid-size open source models, as well as selected closed source ones, and is more comprehensive than most prior work with respect to the scope of evaluated configurations: different types of prompts, output processing methods for generating both class and class probability predictions, as well as few-shot example counts and selection methods. The performance of the most successful configurations is compared to that of conventional classification algorithms. The obtained average PR AUC over 15 challenging datasets above 0.4 for zero-shot prompting and nearly 0.5 for few-shot prompting comes close to that of the naïve Bayes classifier (0.5), the random forest algorithm (0.5 with default settings or 0.55 with hyperparameter tuning) and fine-tuned transformer models (0.5). These results confirm the utility of large language models as text classifiers for non-trivial domains and provide practical recommendations of the most promising setups, including in particular using output token probabilities for class probability prediction.
Mar 12, 2026

Prediction of Grade, Gender, and Academic Performance of Children and Teenagers from Handwriting Using the Sigma-Lognormal Model

Digital handwriting acquisition enables the capture of detailed temporal and kinematic signals reflecting the motor processes underlying writing behavior. While handwriting analysis has been extensively explored in clinical or adult populations, its potential for studying developmental and educational characteristics in children remains less investigated. In this work, we examine whether handwriting dynamics encode information related to student characteristics using a large-scale online dataset collected from Japanese students from elementary school to junior high school. We systematically compare three families of handwriting-derived features: basic statistical descriptors of kinematic signals, entropy-based measures of variability, and parameters obtained from the sigma-lognormal model. Although the dataset contains dense stroke-level recordings, features are aggregated at the student level to enable a controlled comparison between representations. These features are evaluated across three prediction tasks: grade prediction, gender classification, and academic performance classification, using Linear or Logistic Regression and Random Forest models under consistent experimental settings. The results show that handwriting dynamics contain measurable signals related to developmental stage and individual differences, especially for the grade prediction task. These findings highlight the potential of kinematic handwriting analysis and confirm that through their development, children's handwriting evolves toward a lognormal motor organization.
Mar 11, 2026

Cross-Species Transfer Learning for Electrophysiology-to-Transcriptomics Mapping in Cortical GABAergic Interneurons

Single-cell electrophysiological recordings provide a powerful window into neuronal functional diversity and offer an interpretable route for linking intrinsic physiology to transcriptomic identity. Here, we replicate and extend the electrophysiology-to-transcriptomics framework introduced by Gouwens et al. (2020) using publicly available Allen Institute Patch-seq datasets from both mouse and human cortex. We focus on GABAergic inhibitory interneurons to target a subclass structure (Lamp5, Pvalb, Sst, Vip) that is comparable and conserved across species. After quality control, we analyzed 3,699 mouse visual cortex neurons and 506 human neocortical neurons from neurosurgical resections. Using standardized electrophysiological features and sparse PCA, we reproduced the major class-level separations reported in the original mouse study. For supervised prediction, a class-balanced random forest provided a strong feature-engineered baseline in mouse data and a reduced but still informative baseline in human data. We then developed an attention-based BiLSTM that operates directly on the structured IPFX feature-family representation, avoiding sPCA and providing feature-family-level interpretability via learned attention weights. Finally, we evaluated a cross-species transfer setting in which the sequence model is pretrained on mouse data and fine-tuned on human data for an aligned 4-class task, improving human macro-F1 relative to a human-only training baseline. Together, these results confirm reproducibility of the Gouwens pipeline in mouse data, demonstrate that sequence models can match feature-engineered baselines, and show that mouse-to-human transfer learning can provide measurable gains for human subclass prediction.
Mar 8, 2026

A Joint Neural Baseline for Concept, Assertion, and Relation Extraction from Clinical Text

Clinical information extraction (e.g., 2010 i2b2/VA challenge) usually presents tasks of concept recognition, assertion classification, and relation extraction. Jointly modeling the multi-stage tasks in the clinical domain is an underexplored topic. The existing independent task setting (reference inputs given in each stage) makes the joint models not directly comparable to the existing pipeline work. To address these issues, we define a joint task setting and propose a novel end-to-end system to jointly optimize three-stage tasks. We empirically investigate the joint evaluation of our proposal and the pipeline baseline with various embedding techniques: word, contextual, and in-domain contextual embeddings. The proposed joint system substantially outperforms the pipeline baseline by +0.3, +1.4, +3.1 for the concept, assertion, and relation F1. This work bridges joint approaches and clinical information extraction. The proposed approach could serve as a strong joint baseline for future research. The code is publicly available.
Mar 7, 2026

Discovering the Hidden Role of Gini Index In Prompt-based Classification

In classification tasks, the long-tailed minority classes usually offer the predictions that are most important. Yet these classes consistently exhibit low accuracies, whereas a few high-performing classes dominate the game. We pursue a foundational understanding of the hidden role of Gini Index as a tool for detecting and optimizing (debiasing) disparities in class accuracy, focusing on the case of prompt-based classification. We introduce the intuitions, benchmark Gini scores in real-world LLMs and vision models, and thoroughly discuss the insights of Gini not only as a measure of relative accuracy dominance but also as a direct optimization metric. Through rigorous case analyses, we first show that weak to strong relative accuracy imbalance exists in both prompt-based, text and image classification results and regardless of whether the classification is high-dimensional or low-dimensional. Then, we harness the Gini metric to propose a post-hoc model-agnostic bias mitigation method. Experimental results across few-shot news, biomedical, and zero-shot image classification show that our method significantly reduces both relative and absolute accuracy imbalances, minimizing top class relative dominance while elevating weakest classes.
Mar 6, 2026

Fairness May Backfire: When Leveling-Down Occurs in Fair Machine Learning

As machine learning (ML) systems increasingly shape access to credit, jobs, and other opportunities, the fairness of algorithmic decisions has become a central concern. Yet it remains unclear when enforcing fairness constraints in these systems genuinely improves outcomes for affected groups or instead leads to "leveling down," making one or both groups worse off. We address this question in a unified, population-level (Bayes) framework for binary classification under prevalent group fairness notions. Our Bayes approach is distribution-free and algorithm-agnostic, isolating the intrinsic effect of fairness requirements from finite-sample noise and from training and intervention specifics. We analyze two deployment regimes for ML classifiers under common legal and governance constraints: attribute-aware decision-making (sensitive attributes available at decision time) and attribute-blind decision-making (sensitive attributes excluded from prediction). We show that, in the attribute-aware regime, fair ML necessarily (weakly) improves outcomes for the disadvantaged group and (weakly) worsens outcomes for the advantaged group. In contrast, in the attribute-blind regime, the impact of fairness is distribution-dependent: fairness can benefit or harm either group and may shift both groups' outcomes in the same direction, leading to either leveling up or leveling down. We characterize the conditions under which these patterns arise and highlight the role of "masked" candidates in driving them. Overall, our results provide structural guidance on when pursuing algorithmic fairness is likely to improve group outcomes and when it risks systemic leveling down, informing fair ML design and deployment choices.
Mar 6, 2026

Validation of a Small Language Model for DSM-5 Substance Category Classification in Child Welfare Records

Background: Recent studies have demonstrated that large language models (LLMs) can perform binary classification tasks on child welfare narratives, detecting the presence or absence of constructs such as substance-related problems, domestic violence, and firearms involvement. Whether smaller, locally deployable models can move beyond binary detection to classify specific substance types from these narratives remains untested. Objective: To validate a locally hosted LLM classifier for identifying specific substance types aligned with DSM-5 categories in child welfare investigation narratives. Methods: A locally hosted 20-billion-parameter LLM classified child maltreatment investigation narratives from a Midwestern U.S. state. Records previously identified as containing substance-related problems were passed to a second classification stage targeting seven DSM-5 substance categories. Expert human review of 900 stratified cases assessed classification precision, recall, and inter-method reliability (Cohen's kappa). Test-retest stability was evaluated using approximately 15,000 independently classified records. Results: Five substance categories achieved almost perfect inter-method agreement (kappa = 0.94-1.00): alcohol, cannabis, opioid, stimulant, and sedative/hypnotic/anxiolytic. Classification precision ranged from 92% to 100% for these categories. Two low-prevalence categories (hallucinogen, inhalant) performed poorly. Test-retest agreement ranged from 92.1% to 99.1% across the seven categories. Conclusions: A small, locally hosted LLM can reliably classify substance types from child welfare administrative text, extending prior work on binary classification to multi-label substance identification.