Cognitive Digital Twins

The purpose of this paper is the identification of high-fidelity digital twin data models from numerical code outputs by non-intrusive techniques (i.e., not requiring Galerkin projection of the governing equations onto the reduced modes basis). In this paper the author defines the concept of the digital twin data model (DTM) as a model of reduced complexity that has the main feature of mirroring the original process behavior. The significant advantage of a DTM is to reproduce the dynamics with high accuracy and reduced costs in CPU time and hardware for settings difficult to explore because of the complexity of the dynamics over time. This paper introduces a new framework for creating efficient digital twin data models by combining two state-of-the-art tools: randomized dynamic mode decomposition and deep learning artificial intelligence. It is shown that the outputs are consistent with the original source data with the advantage of reduced complexity. The DTMs are investigated in the numerical simulation of three shock wave phenomena with increasing complexity. The author performs a thorough assessment of the performance of the new digital twin data models in terms of numerical accuracy and computational efficiency.

Post-treatment MRI in patients with glioma provides serial observations for updating patient-specific tumor-state proxy estimates, but variable appearances and trajectories complicate forecasting. We formulate forecasting as an observation-aware digital-twin update in which an intermediate observation anchors the patient-specific state. Among 203 patients and 594 follow-up time points, a predefined no-new-treatment criterion retained 120 of 236 candidate triplets, split into 81/24/15 training/validation/test triplets at the patient level. Each time point was represented by a continuous voxel-wise tumor-state proxy map in [0,1] derived from MRI lesion labels. A SegMamba-based single-step forecaster predicted update proposals from multimodal source-state tensors. Observation-Anchored Selective Assimilation (OASA) retained the observed intermediate proxy as the state anchor and selectively applied updates through a validation-selected tiered case-level rule and voxel-wise soft gate. We compared initial-scan forecasting, rollout without assimilation, latest-observation persistence, direct prediction, OASA, OASA + calibration, and morphological dilation. Checkpoints, OASA rules, and calibration thresholds were selected using validation data only. Across three seeds on 15 held-out test triplets, OASA maintained Dice at $\tau$ = 0.2 comparable to persistence (0.6071 $\pm$ 0.0025 vs. 0.6070) while yielding numerically higher Dice at $\tau$ = 0.5 (0.4269 $\pm$ 0.0079 vs. 0.3981), with a small RMSE increase. Calibration increased Dice at $\tau$ = 0.2 to 0.6178 $\pm$ 0.0025, increased false-positive (FP) support (11,836$\rightarrow$18,663), and reduced false-negative (FN) support (22,107$\rightarrow$17,536). This reflects near-threshold support calibration rather than improved biological predictive capability. Code is publicly available at https://github.com/jsudg436/longitudinal-proxy-forecasting.

As Digital Twin (DT) systems evolve beyond state synchronization toward task-oriented and knowledge-driven operation, Cognitive Digital Twins (CDTs) have emerged as an extension that incorporates cognitive capabilities into twin operation. Existing CDT studies often focus on specific enabling techniques, such as learning modules, knowledge graphs, and large language models, while providing limited insight into how cognition can be systematically integrated into DT architectures. To address this issue, this paper proposes a four-layer CDT architecture consisting of the physical layer, digital-twin layer, cognitive layer, and task layer. The proposed architecture establishes a self-evolving closed operational loop spanning these four layers, in which physical states are synchronized into digital representations, cognition constructs task-specific cognitive models through knowledge, memory, and attention, and task-level decisions are generated under practical constraints. Operational feedback further refines cognitive experience and updates relationships and annotations in the digital representation, enabling subsequent task interpretation, initiation, and reasoning to evolve with system operation. Based on this framework, two representative operation modes are characterized: user-request-driven cognition and self-driven cognition. We further discuss key enabling mechanisms and deployment challenges associated with semantic communication, knowledge querying, task orchestration, and closed-loop synchronization. A lightweight simulation study illustrates reliable closed-loop task feasibility under limited semantic information and improved operational efficiency through accumulated task experience. The proposed framework provides a structured foundation for the design and development of future CDT systems.

Rapid bespoke commissioning of the Cognitive Digital Twin (CDT) is a major challenge in reconfigurable manufacturing. Traditional digital twin (DT) construction methods primarily focus on geometric reconstruction, often neglecting the deep semantic integration and functional interoperability necessary for autonomous reasoning. This paper proposes an agent-based, AI-driven workflow to automate end-to-end CDT debugging. The system utilises LangGraph as a multi-agent orchestration engine to achieve dual-path synthesis: the semantic path extracts technical specifications from unstructured documents using Retrieval Augmented Generation (RAG), while the functional path autonomously discovers and binds to real-time industrial telemetry data using Model Context Protocol (MCP). Experimental validation in a robotic machining cell demonstrates that the system achieves a mean average accuracy (mAP) of 97.2% in perception and reduces the deployment cycle from several weeks to an average of 2 hours, marking a paradigm shift from manual scripting to autonomous orchestration.

Head-and-neck (HN) proton therapy is highly sensitive to anatomical change over a 4-to-6-week course, as tumor shrinkage, weight loss, and setup variation can misposition the Bragg peak near critical organs such as the parotids, oral cavity, brainstem, and spinal cord, leading to target underdosing or organ-at-risk overdosing. Online adaptive proton therapy replans on the anatomy of the day, yet standard workflows rely on offline replanning that requires repeated CT acquisition and roughly a week of preparation, adding burden, cost, and delay. We investigate whether a patient's treatment-day anatomy can be predicted before image acquisition by transferring longitudinal change from a population database. We propose a digital-twin framework built on a pretrained foundation-model deformable registration network used without patient-specific training. A first registration aligns a prior patient's planning CT to the target and carries the prior's during-treatment quality assurance CT (QACT) into the target frame; a second registration estimates the prior's planning-to-QACT change, which is then applied to the target's own planning CT to synthesize predicted CTs (pdCTs) with propagated contours. Using 88 HN patients, each with a planning CT and three QACTs, we show that pdCTs better match treatment-day anatomy than the static planning CT. Compared with the planning CT alone, normalized cross-correlation improves by 22.8%, Dice for organs-at-risk by 20.2%, and CT-number error decreases by 23.4%. Gains are largest for patients with major anatomical change and negligible when anatomy is stable. This cross-patient motion transfer leverages the digital-twin concept to anticipate treatment-day anatomy, enabling personalized online adaptive proton therapy without repeated imaging.

Digital twins are often used to predict how a system would respond to an intervention. In systems with feedback, a twin must reproduce an equilibrium counterfactual, and a twin developed in one domain may fail after mechanisms change. We study when these predictions can be validated and transported. For equilibrium causal games, we give conditions on the mechanisms, equilibrium selection, and intervention design under which agreement with experimental distributions identifies the counterfactual of interest. We show why agreement of means and covariances is insufficient for distributional queries. We then introduce cyclic selection diagrams and derive criteria for direct reuse and for hybrid models that combine invariant source mechanisms with target information. An impossibility result constructs systems that agree under every experiment in a finite design but disagree on the target counterfactual, showing that validation requires structural assumptions. For linear models, we derive intervention requirements that depend on the mechanisms that changed, the observation model, and graph support. When point identification fails, we characterize the remaining range of query values. We also provide statistical tests for reconstructed means and covariances and illustrate the theory in synthetic feedback systems.

Brain tumor progression exhibits spatially heterogeneous growth, patient-specific treatment response, and complex interactions with surrounding anatomy, making accurate long-term prediction challenging. We propose an AI-augmented adaptive digital twin (DT) framework for brain tumor evolution prediction and treatment scheduling. The framework integrates an interpretable reaction--diffusion (RD) model, a 3D residual learning module for model-form correction, patient-specific DT updating during recursive rollout, and model predictive control (MPC) for constrained chemotherapy and radiotherapy scheduling. Experiments on 387 synthetic tumor trajectories with 120-step evolution show that the baseline RD model captures tumor location and overall temporal behavior but underestimates heterogeneous tumor burden during long-horizon prediction. Hybrid RD--residual modeling reduces masked voxel-wise mean squared error by 84.3% and increases Dice overlap by 43.5% relative to the RD baseline under dense simulated observations. Online DT updating further reduces mean squared error by 45.9% and improves Dice overlap by 9.6% compared with the non-updated hybrid model. In MPC-based scheduling simulations, the updated DT controller reduces final tumor burden by 22.4% relative to a fixed treatment schedule under the terminal-burden objective. Together, these results demonstrate a unified framework for patient-specific initialization, mechanistic modeling, adaptive learning, and constrained treatment optimization. Although validated using patient-data-informed synthetic trajectories rather than clinical longitudinal data, the proposed framework establishes a foundation for future translation to real-world adaptive treatment planning.

Autonomous driving systems require reliable safety validation before real-world deployment. However, large-scale road testing is costly, difffcult to reproduce, and inefffcient for exposing rare safety-critical scenarios. Conventional simulation improves repeatability, but an offfine simulator alone cannot continuously connect physical trafffc states, virtual reconstruction, algorithm evaluation, and scenario evolution. This paper proposes a risk-ffeld enhanced closed-loop digital twin framework for autonomous driving safety validation. The framework integrates physical data acquisition, data synchronization, virtual twin reconstruction, risk-aware scenario generation, autonomous driving algorithm evaluation, and safety analysis. A driving risk ffeld is introduced as a uniffed intermediate representation to describe obstacle, lane-departure, road-boundary, time-to-collision, and comfort-related risks around the ego vehicle. The risk ffeld ranks high-risk scenarios in the digital twin scenario library and provides dense safety guidance for reinforcement learning-based driving policies. A simulation-style evaluation protocol is designed to compare conventional reinforcement learning baselines, risk-penalty baselines, and the proposed risk-ffeld guided method. The study indicates that embedding explicit risk structure into digital twins can make autonomous driving validation more targeted, interpretable, and reusable, while its practical effectiveness remains bounded by model ffdelity, risk calibration, and sim-to-real transfer.

Accurately predicting the spatiotemporal evolution of amyloid-$β$ and tau proteins at the individual level is critical for improving the diagnosis and treatment of Alzheimer's disease. We consider the problem of constructing patient-specific digital twins that model the propagation of these biomarkers on the cortical surface using reaction--diffusion dynamics. A major challenge is that the underlying nonlinear aggregation mechanisms are unknown and must be inferred from sparse, noisy, and heterogeneous longitudinal PET imaging data. To address this, we develop a data-driven framework that learns biomarker dynamics directly from clinical observations. The approach combines operator learning with reduced-order representations to infer governing equations of disease progression from data. Using this framework, we achieve predictive accuracies of 87% for amyloid-$β$ and 81% for tau. Building on the learned dynamics, we further formulate a PDE-constrained optimal control problem to design personalized therapeutic strategies that regulate pathological protein propagation. By integrating data-driven dynamical modeling with treatment optimization, the proposed digital twin framework provides an interpretable and predictive platform for understanding disease progression and enabling precision interventions in neurodegenerative disorders.

Digital twins (DTs) have become a potential technology to perform risk-free simulation of physical entities for deterministic and high-reliability services in diverse scenarios such as autonomous driving and low-altitude economy. In the autonomous driving scenario, traditional DT methods that rely solely on vehicle's real-time state synchronization, however, might lead to unacceptable computing and communication consumption for construction of high-fidelity DT with redundant data. To address this issue, we first propose a query-driven DT architecture to enable the DT to actively request the desired environment data from vehicles based on its simulation result. Then, we formulate an optimization problem whose goal is to minimize autonomous driving position error while accounting for DT fidelity and communication constraints. We also design a cross-time-step progressive query mechanism to further improve communication efficiency. The simulation results show that our proposed method achieves a 24% reduction in planning position error compared to traditional methods, while reducing communication overhead by 40%.

UAV-based pavement inspection can reduce the cost and risk of road-surface monitoring, but real-world deployment remains difficult when traffic, pedestrians, and temporary occlusions affect defect visibility. This paper presents a Unity-based digital twin framework for traffic-aware UAV pavement monitoring in open-traffic conditions. The proposed environment integrates procedurally generated road defects, dynamic traffic agents, autonomous UAV navigation, and a multitask YOLOv8n perception module for detecting road defects, pedestrians, and vehicles while classifying road-defect subtypes. After synthetic-domain fine-tuning, the perception model achieved 0.959 mAP@0.5 and 0.940 macro F1-score on a held-out synthetic test set generated from the simulator. The digital twin was then used to evaluate hover-and-recheck, micro-repositioning, and skip-and-revisit recovery strategies across different traffic densities and flight altitudes. Results show that flight altitude strongly affects inspection coverage, while recovery strategies introduce different trade-offs between coverage, mission duration, energy consumption, and revisit behaviour. These findings demonstrate that digital twins can support the development and evaluation of traffic-aware UAV inspection strategies before real-world deployment. The full implementation and trained models are available at https://github.com/EdwinTSalcedo/RDMO-DigitalTwin.

Despite steady advances in flexible automation in sectors such as electronics and automotive manufacturing, apparel automation remains challenging because fabrics are deformable and difficult to manipulate with robots. This paper presents a deployment-oriented case study of a robotic sewing system for denim manufacturing, emphasizing the system-level integration required for practical adoption. At the engineering level, a digital thread module parses DXF production drawings into process parameters and executable robot trajectories, reducing manual programming effort and enabling rapid re-targeting across sewing operations. In parallel, a digital twin of the workcell is used during pre-deployment to validate reach and clearance, refine layout and sequencing, evaluate operator access, and assess cycle-time compatibility with upstream and downstream tasks, thereby reducing commissioning risk. At deployment, the system integrates a collaborative robot with conventional sewing equipment, welding, suction fixtures, and machine-level controllers through an interoperability layer. Runtime monitoring and verification, including seam monitoring, collision checking, and trajectory-level validation, improve robustness under environmental variability, while operator-facing training and guidance tools support setup, troubleshooting, and technology adoption. Two staged factory deployments on denim shorts, covering 2D pocket operations and 3D garment-shaping seams, show that digital-twin-based validation, digital-thread-driven task generation, interoperability, runtime verification, and operator training are important for scaling robotic apparel automation.

Business intelligence (BI) increasingly combines dashboard interaction with LLM-based assistance, but these two modes often fall out of sync during multi-step analysis. As users switch between direct dashboard manipulation and natural-language queries, it becomes difficult to preserve a consistent analytical state across filters, hierarchies, metrics, and chart context. We present TwinBI, an agentic digital-twin framework that couples an LLM-based agent system with an executable BI dashboard state. TwinBI unifies conversational interaction, dashboard manipulation, semantic grounding, and provenance tracking through a shared analytical state reconstructed from a unified interaction log. It also exposes artifacts such as schema views, SQL, logs, and an /insights command for state-grounded analytical summaries. We evaluate TwinBI in two complementary ways. In a controlled A/B benchmark with the same backbone agent, TwinBI improves exact-match accuracy from 43.3% to 63.3%, partial-credit accuracy from 48.3% to 70.8%, and substantially reduces timeout rate from 40.0% to 10.0% relative to Dashboard alone. In a usability study, participants benefited from the integrated dashboard-and-chat workflow, with high task accuracy, moderate workload, and favorable ratings for state-aware interaction mechanisms. These results suggest that TwinBI improves both agent-level analytical reliability and user-facing analytical support by turning visible dashboard state into richer actionable context. Our dataset and source code are available at: https://github.com/simonjisu/TwinBI

Alzheimer's disease (AD) progression is highly heterogeneous and is typically observed through sparse and irregular longitudinal data, posing challenges for prediction and personalised monitoring. Existing machine learning approaches have improved AD prediction using multimodal data, yet often focus on static classification or cohort-level risk estimation, providing limited support for subject-specific modelling and uncertainty-aware reasoning. To address these limitations, we present a personalised digital twin framework for AD prediction and scenario-based analysis using multimodal longitudinal data. The proposed approach integrates complementary modelling strategies to capture clinical transitions and temporal dependencies across visits. Using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), including cognitive assessments, clinical variables, and MRI-derived phenotypes, the framework predicts cognitive status and diagnostic categories while quantifying predictive uncertainty and enabling patient-specific what-if trajectory analysis. Evaluation on leak-free subject-level splits demonstrates strong performance in score forecasting and diagnosis classification. In this sparse and irregular ADNI setting, transition-based modelling of adjacent visits achieved higher predictive accuracy than the sequence-based branch, suggesting that local transition modelling may be more data-efficient. While sequence models remain valuable for uncertainty-aware trajectory forecasting, local transition modelling offers a more data-efficient and robust predictive strategy. These findings highlight the importance of aligning temporal modelling strategies with clinical data structure and suggest that transition-based digital twin formulations may provide a practical and interpretable approach for personalised disease forecasting in neurodegenerative disorders.

Digital twins (DTs) allow the digitalization of road infrastructure inspection, though this is hindered by limited annotated data. This work exploits the relational nature of continuous asset condition monitoring to reformulate image-based defect detection as image difference classification (IDC) to reduce data reliance. This was evaluated in a case study on low-resource traffic sign inspection with different IDC classifiers using a newly-curated, high quality dataset. Results indicate that the instruction-based classifier outperforms encoder-based ones and gains from comparison with reference images. This shows that IDC can be an effective task modeling for tackling data constraints in infrastructure inspection and DT asset condition updating.

Alternatives to soil-based horticulture, such as hydroponics, have been developed to respond to food distribution concerns for dense urban centers. A new system was developed to track an individual lettuce plant's growth in a hydroponic environment, utilizing streams of measured information and available models to continuously update the growth trajectory estimates for a plant. These "digital twin" models were integrated into an operating hydroponic greenhouse, with custom horticultural and sensor hardware to grow and measure relevant information. To aid in updating model parameters, plant yield was continuously measured with a custom neural network, using RGB-D images of the plants as an input. The network, trained on a collected dataset of 1300 images, was able to estimate mass within 1.5 g of the ground-truth value. After integration into the custom system, digital twin growth projections could approximate future yield between one and four days in the future, maintaining around a 2 g forecasting error.

Generating complete digital twins from videos requires precise camera control, global scene coverage, and strict spatial-temporal consistency constraints that remain challenging for perspective video generators due to their limited field of view (FoV). Their narrow FoV forces long or multi-view trajectories, amplifying cross-view inconsistency and temporal drift. We argue that 360° video generation offers a natural solution: panoramic coverage simplifies trajectory design and provides a strong global context for maintaining coherence. We introduce Pantheon360: Taming Digital Twin Generation via 3D-Aware 360° Video Diffusion, a controllable 360° video generation framework that synthesizes high-fidelity videos from sparse 360° inputs. The key idea is an explicit 3D Cache, reconstructed from the input, which serves as a geometric scaffold for any user-defined camera path. This allows the diffusion model to focus on photorealistic texture refinement while the 3D Cache enforces global geometric consistency. Experiments show that Pantheon360 achieves superior visual quality and unmatched geometric coherence, enabling reliable and flexible 360° scene generation for downstream simulation and digital-twin applications.

Comprehensive and efficient validation of connected and automated vehicles (CAVs) is critical prior to real-world deployment. While simulation-based testing offers scalability, existing approaches often lack seamless integration with real vehicles and field data, limiting their fidelity in capturing dynamic, real-world interactions. To bridge this gap, this paper proposes a novel real-time hybrid digital twin platform. Its core innovation lies in the tight coupling of a high-fidelity CARLA-SUMO co-simulation with a physical test site and vehicle via a low-latency Vehicle-to-Everything (V2X) communication link. A custom-developed middleware serves as the critical bridge, synchronizing a real CAV's kinematic state as a shadow vehicle in the simulation and translating virtual control commands into chassis-actuating Controller Area Network (CAN) messages for closed-loop control. Detailed implementation includes using photogrammetry for full-scale asset reconstruction and a cloud-edge collaborative architecture for scalable, multi-user operation. Experimental results demonstrate stable synchronization and effective closed-loop control with low latency, confirming the platform's practicality for multi-scenario CAV verification.

AI-driven flood digital twins demand fast hydrodynamic surrogates for ensemble forecasting and observation assimilation. Yet even GPU-accelerated two-dimensional shallow water equation (SWE) solvers still require $\sim 55$ minutes per $96$-hour run on a $\sim 4.2$-million-active-cell metropolitan basin (the DesPlaines River basin at $30\,\mathrm{m}$ resolution), making such workloads prohibitive at native resolution. We present the Conditional Latent Dynamics Network (CLDNet): a low-dimensional latent neural ODE driven by rainfall, paired with a coordinate-based decoder conditioned on static terrain (elevation, slope, Manning roughness) that reconstructs depth and discharge at arbitrary query points. Pointwise decoding decouples memory from grid size and handles irregular watersheds natively, enabling metropolitan-scale training on a single compute node and direct queries at exact gauge coordinates without raster snapping. We evaluate CLDNet on a synthetic $250{,}000$-cell Texas benchmark and on a new DesPlaines case study of $114$ real-rainfall StageIV storms whose reference simulator we validate against United States Geological Survey (USGS) gauges at the April2013 flood-of-record (Nash--Sutcliffe efficiency $0.57$--$0.94$ on mean-recentered water-surface elevation). CLDNet roughly halves the relative root-mean-squared error of an unconditional baseline, outperforms regular-grid VAE--ConvLSTM and FNO baselines on the Texas benchmark (both presuppose a Cartesian grid and do not apply to the irregular Des~Plaines watershed), reaches a critical success index of $\approx 86\%$ at the $0.5\,\mathrm{m}$ inundation threshold, and produces a full $96$-hour basin-wide forecast in $\sim 29$ seconds -- a $\sim 115\times$ speedup.

The Industry Foundation Classes (IFC) standard is central to building data exchange across the lifecycle, from design and construction to facility management and Digital Twin integration. In operational settings, stakeholders increasingly require access to building information without specialist knowledge of IFC's complex, deeply nested schema, motivating natural language interfaces. Existing LLM-based querying approaches typically rely on a single data representation, which is not equally suited to attribute retrieval and spatial reasoning. We present IfcLLM, a framework that combines complementary relational and graph representations, routing each query type to the more suitable backend. An LLM agent integrates both through iterative retry-and-refine reasoning, recovering from failures without user input. Evaluated across three IFC models on 30 query scenarios, our implementation achieves first-attempt accuracy between 93.3% and 100%, with all failed queries resolved via a fallback LLM. Built on an open-weight LLM, it supports local deployment in data-sensitive AEC settings.

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike traditional predictive models, the framework focuses on generating interpretable simulated trajectories rather than clinically validated outcomes. Evaluation is conducted using a public dataset combined with controlled synthetic scenarios to illustrate temporal behavior and intervention effects. Results illustrate the feasibility of integrating prediction with counterfactual simulation for decision-aware analysis. This work does not claim clinical readiness but provides a foundation for future research on simulation-driven digital twin systems in healthcare.

Network digital twins (NDTs) are transforming network management by offering precise virtual replicas of physical network systems. However, their reliance on diverse and sensitive data introduces significant challenges related to data management, regulatory compliance, and user privacy. In scenarios where selective data removal is necessary, such as device deactivation, network reconfiguration, or regulatory compliance, traditional approaches often fall short of preserving the integrity of the twin model. To address this gap, we introduce a network digital untwinning framework that enables the targeted removal of deprecated NDT contributions while maintaining model integrity. Our approach comprises two complementary components: Single Request Untwinning (\algO) and Parallel Request Untwinning (\algM) mechanisms. \algO leverages connectivity metrics based on geographical proximity, data distribution, and network-level attributes to identify and remove the target NDT along with its propagating influence. This is achieved through an optimally selected rollback checkpoint augmented with injected Gaussian noise, followed by a precise remapping phase. \algM extends this mechanism to efficiently handle multiple removal requests by clustering NDTs with similar attributes and performing a coordinated rollback and untwinning schedule. We provide theoretical guarantees on model indistinguishability from scratch-built twins, and validate the framework through extensive experiments on real-world traffic data, demonstrating its effectiveness and operational efficiency.

Wastewater treatment plants (WWTPs) need digital-twin-style decision support tools that can simulate plant response under prescribed control plans, tolerate irregular and missing sensing, and remain informative over 12-36 h planning horizons. Meeting these requirements with full-scale plant data remains an open engineering-AI challenge. We present CCSS-RS, a controlled continuous-time state-space model that separates historical state inference from future control and exogenous rollout. The model combines typed context encoding, gain-weighted forcing of prescribed and forecast drivers, semigroup-consistent rollouts, and Student-t plus hurdle outputs for heavy-tailed and zero-inflated WWTP sensor data. On the public Avedøre full-scale benchmark, with 906,815 timesteps, 43% missingness, and 1-20 min irregular sampling, CCSS-RS achieves RMSE 0.696 and CRPS 0.349 at H=1000 across 10,000 test windows. This reduces RMSE by 40-46% relative to Neural CDE baselines and by 31-35% relative to simplified internal variants. Four case studies using a frozen checkpoint on test data demonstrate operational value: oxygen-setpoint perturbations shift predicted ammonium by -2.3 to +1.4 over horizons 300-1000; a smoothed setpoint plan ranks first in multi-criterion screening; context-only sensor outages raise monitored-variable RMSE by at most 10%; and ammonium, nitrate, and oxygen remain more accurate than persistence throughout the rollout. These results establish CCSS-RS as a practical learned simulator for offline scenario screening in industrial wastewater treatment, complementary to mechanistic models.

As AI systems become increasingly persistent and personalized, they make possible a class of technologies that we call cognitive digital twins (CDTs): dynamic computational representations of a specific person's cognition, updated from behavioral, contextual, or physiological data in order to model, predict, or simulate that person's cognition, or to act as that person's communicative or decision-making proxy. CDTs combine cognitive inference with longitudinal representation, simulation, and proxy action in ways that existing governance strategies for personal assistants, autonomous agents, recommender systems, and automated decision systems only partially address. This paper makes four contributions. First, we define CDTs and distinguish them from adjacent systems. Second, we introduce a 5A governance framework organized around authority, autonomy, access and control, accountability, and availability. Third, we identify CDT-specific risks, from misrepresentation and epistemic authority shifts to shadow twins, simulated participation, proxy action, and proxy-power asymmetries. Fourth, we analyze governance gaps and propose requirements for high-risk CDTs that strengthen consent, purpose limitation, validity, traceability, contestation, independent review, and model retirement. Existing frameworks primarily regulate data processing, automated decisions, or autonomous actions; CDTs also require governance at the level of cognitive representation itself, before any final decision or external action occurs. We argue that CDTs require governance not only because they can act for people, but because they can become infrastructures through which cognition is represented, simulated, classified, and operationalized.