Conditional Diffusion Models

Subseasonal-to-seasonal (S2S) precipitation forecasting has substantial financial and societal impact, yet remains challenging because of weak predictive signals, high associated uncertainty, and the computational cost of operational systems, which constrains simulation fidelity. We introduce SimCast-S2S, a generative latent-diffusion framework for probabilistic S2S precipitation forecasting that addresses three major bottlenecks in data-driven prediction. First, because S2S prediction requires uncertainty quantification rather than only deterministic point forecasts, SimCast-S2S is the first data-driven system that uses a diffusion-based generative pipeline for S2S prediction, enabling effective sampling from the underlying conditional distribution. Second, since generating large probabilistic ensembles is computationally costly in physical space, SimCast-S2S instead operates in a compact latent space learned by variational autoencoders (VAEs), enabling efficient large-ensemble generation. Third, diffusion models typically require large training datasets; SimCast-S2S overcomes this via transfer learning with low-rank adaptation (LoRA), pretraining on large ensembles of climate simulations before fine-tuning on limited reanalysis data. On reanalysis data, SimCast-S2S outperforms deep learning baselines, including convolutional neural networks and U-Net architectures. Notably, despite using only a subset of atmospheric input variables and no post-processing, bias correction, or calibration, SimCast-S2S remains competitive with, and in many aspects outperforms, state-of-the-art operational systems such as the ECMWF-S2S baseline. These results indicate that latent generative modeling combined with simulation-to-reanalysis transfer learning offers an efficient and scalable path toward data-driven probabilistic S2S precipitation forecasting.

Hyperspectral pansharpening aims to reconstruct a high resolution hyperspectral (HRHS) image from a panchromatic (PAN) image and a low resolution hyperspectral (LRHS) image while preserving both spatial details and spectral fidelity. Recent diffusion based methods exploit pretrained image priors by generating a low dimensional representation and subsequently mapping it to the hyperspectral domain. However, the observed panchromatic and hyperspectral images are typically imposed only through external reconstruction objectives, limiting their direct interaction with the diffusion prior. To address this issue, we propose dual-modality image-prompted diffusion model (DIDM) for zero shot hyperspectral pansharpening. DIDM encodes the low resolution hyperspectral and panchromatic observations into spectral and spatial prompt tokens, respectively, and injects them into intermediate features of a frozen remote sensing diffusion model through cross attention, allowing complementary spectral and spatial information to directly guide diffusion feature evolution. In addition, we introduce a panchromatic guided weighted pixel aware total variation regularizer that combines low resolution hyperspectral degradation fidelity and panchromatic response fidelity with gradient adaptive structural regularization, thereby preserving structural discontinuities while suppressing spurious variations in homogeneous regions. Extensive experiments on Pavia, Chikusei, and Houston under reduced resolution protocols show that DIDM achieves the best performance across all evaluated metrics, while full resolution evaluation on FR1 yields the highest HQNR among the compared methods. These results demonstrate that internal dual modality prompting and panchromatic guided structural regularization provide an effective balance between spatial detail enhancement and spectral preservation.

During standard radiotherapy planning, repeated CT acquisitions are often required for patient registration, verification, and adaptive planning, resulting in increased cumulative X-ray dose. To mitigate this, low-dose cone-beam CT (CBCT) is routinely acquired during treatment delivery. However, CBCT image quality remains insufficient for accurate dose calculation and adaptive radiotherapy planning due to increased scatter, noise, beam hardening, and reconstruction related artifacts. This study develops a supervised deep learning based CBCT to CT synthesis framework using a conditional denoising diffusion probabilistic model (DDPM), where the generation of a CT-based planning for accurate positioning and dose calculation is obtained using generative models with low dose CBCT imaging. Beyond demonstrating CBCT to CT synthesis, the primary objective is to investigate how the representation of CBCT input data, either standard clinical DICOM CBCT images or filtered back-projection (FDK) reconstructions from raw projection data, affects the performance of diffusion based CT synthesis. The overarching aim is to assess whether physics aware CBCT representations better support CT-equivalent image quality while maintaining reduced imaging dose in radiotherapy workflows.

Precipitation nowcasting predicts the spatiotemporal evolution of future radar echoes from historical radar echo sequences, thereby estimating the occurrence, development, and movement of precipitation over the near term. In recent years, deep learning has become an important approach to precipitation nowcasting. Although state-of-the-art models can generally capture the overall spatial distribution of future precipitation, their predictions still exhibit substantial biases in radar echo intensity at individual locations. This observation motivates a more targeted strategy for reducing forecast errors. Instead of regenerating an entire radar echo sequence without spatial constraints, the predicted precipitation structure can be used to guide the refinement of echo intensities at individual locations. This structure-guided refinement directly targets echo intensity biases. Accordingly, we propose FreCast, a two-stage framework for radar echo prediction. The first stage generates an initial forecast of future radar echoes. The second stage uses the spatial structure of the initial forecast as a constraint to further correct intensity biases at individual locations in the first-stage prediction. Experiments on three datasets demonstrate that FreCast achieves consistent improvements across forecast skill metrics. Qualitative results further show that FreCast better preserves rainband continuity and intense precipitation structures at longer lead times.

This work proposes deep nonparametric Instrumental variable quantile regression (IVQR), a two-stage estimator that combines conditional diffusion modeling with a kernel-smoothed conditional moment formulation. In the first stage, we estimate the joint conditional distribution of the outcome and endogenous covariates given the instrument using a variance-preserving conditional diffusion model. In the second stage, we approximate the conditional moment operator through Monte Carlo sampling and a kernel-smoothed surrogate for the indicator function, and then estimate the structural quantile function by empirical risk minimization over deep neural networks. We establish an excess-risk bound for the proposed estimator and derive end-to-end total variation guarantees for the conditional diffusion model under unbounded support, explicitly accounting for score estimation, early stopping, and discretization errors. Our theory is developed under a polynomial-tail envelope on the data distribution and degenerates continuously to the exponential setting: as the tail index grows, the obtained excess-risk rate converges to the minimax-optimal rate of nonparametric regression, thus our heavy-tailed theory covers the classical light-tailed nonparametric guarantees as a limiting case. Simulation studies and a real-data application demonstrate that the proposed method outperforms existing nonparametric IVQR approaches, with gains that become increasingly pronounced as the dimensionality of the covariates and instruments increases.

Face inpainting with diffusion models has recently achieved impressive visual quality, yet preserving identity fidelity under significant occlusion and conflicting text guidance remains a major challenge. To address this issue, we present Reference Semantic Inpainting for Face (ReSem-Face), a cascaded diffusion framework that introduces an explicit identity-conditioned semantic prior for multi-reference face inpainting. Our approach distills representative identity features from multiple references to reconstruct missing semantic regions, which then guide the diffusion process through a multi-stream conditioning architecture. This design provides strong semantic constraints when pixels are absent and stabilizes identity reconstruction while remaining compatible with prompt-driven edits. Experiments on CelebAHQ-IDI-5 and VGGFace2 demonstrate that ReSem-Face yields more reliable identity-preserving completion under severe semantic masks and improves text-controlled editing quality compared with representative baselines.

Multimodal named entity recognition (MNER) determines whether each candidate span and entity-type hypothesis is supported by joint textual and visual evidence. Existing imagine-and-compare verifiers map each (span, type) pair to one predicted visual feature, compressing diverse visual realisations into a single prototype and providing a compatibility score without explicit probabilistic semantics. We introduce DiffImaginE, which formulates MNER type verification as conditional latent diffusion inference. Given span-localised visual evidence, a type-conditioned denoiser predicts noise injected into its standardised latent. The resulting denoising error provides an ELBO-consistent surrogate for type-conditional negative log-likelihood, allowing competing type hypotheses to be ranked by how well they explain the observation. DiffImaginE retains a standard multimodal encoder stack and replaces the deterministic verifier with a classifier-free-guided diffusion scorer trained using Min-SNR weighting. We directly supervise per-type diffusion scores as classification logits, learn aggregation across noise levels, and use antithetic sampling to reduce Monte Carlo comparison variance. Our analysis shows that classifier-free guidance sharpens the induced type posterior and characterises when antithetic pairing reduces variance at equal denoiser cost. Experiments on Twitter-2015 and Twitter-2017 show consistent gains over a matched deterministic ImaginE control under the same encoder, auxiliary objectives, and evaluation protocol, supported by ablations and paired significance tests.

Autoregressive models accumulate error over long rollouts, yet at deployment there is no ground truth to measure it against. We train a single conditional latent diffusion model that steps a dynamical system forward or backward in time via a direction flag, and show that this bidirectionality supplies a measurement-free test-time error signal: rolling forward $i$ steps and then backward $i$ steps must return the model to its start, so the round-trip discrepancy $\mathcal{C}_i$ is a self-supervised proxy for the unobservable rollout error: no ensembles, no held-out data, no governing equations, for one extra rollout. We validate on compressible magnetohydrodynamics (MHD), an astrophysical turbulent radiative mixing layer, and natural face videos (CelebV-HQ). On held-out MHD trajectories, $\mathcal{C}_i$ ranks rollout error (Spearman $0.91$-$0.98$ at fixed depth; $0.69 \pm 0.16$ within trajectories), and a simple calibrator fit on training rollouts predicts its magnitude to within $1.14\times$ ($68\%$) and $1.29\times$ ($95\%$) with near-nominal coverage - one nat beyond a depth-only predictor, transferring to all six decoded physical fields. The same signal flags the out-of-distribution Orszag-Tang vortex (AUROC $0.98$; $1.0$ by depth $10$) exactly where sampling-dispersion baselines invert, and it cuts incurred error by $15\%$ at $80\%$ coverage - three times the depth-only baseline. Bidirectional training comes at negative cost, beating direction specialists in both directions, and the backward direction doubles as a fast inverse solver. On LE-PDE-UQ's turbulent Navier-Stokes benchmark, a single bidirectional model reaches accuracy within $1.3\times$ of their ten-model ensemble at a tenth of the training cost, with the best training-free pixel-level calibration. Round-trip consistency turns reversibility into a practical trust signal for generative models.

Utility data (e.g., electricity, water, and gas consumption), collected by ubiquitous sensors and embedded devices, often contains substantial missing values due to various factors such as device failures and data transmission issues. The data missingness can severely impact utility billing accuracy, hinder demand forecasting, and disrupt efficient utility supply management. As a result, utility data imputation has attracted much interest from both industry and academia. While many studies have attempted to address this issue, most of them rely on aggregated datasets for training, overlooking rich user behavior information, which could provide valuable insights for more accurate imputation. However, learning comprehensive user behavior from long-term, diverse, and incomplete utility data remains a significant challenge. Moreover, leveraging user behavior information to guide imputation is nontrivial due to the indirect nature of the correlations. To address these challenges, we propose MBDiff, a Multi-view Behavior-aware Diffusion Model for Probabilistic Utility Data Imputation. MBDiff incorporates two key technical components: (i) a multi-view User Behavior Extraction module that learns comprehensive user behavior from multiple perspectives, including global, local, and instance-level views; and (ii) a behavior-aware conditional diffusion model consisting of a reference selection module and a conditional attentional denoising network to impute utility data in a computationally efficient manner. We implement and evaluate MBDiff by collaborating with one of the largest municipal utility providers in Florida. Experimental results demonstrate our proposed MBDiff effectively outperforms state-of-the-art baselines, e.g., it improves 7.04% and 29.1% on the electricity and water usage datasets for block missingness imputation, respectively.

Commercial mapping partnerships are often unavailable in low-resource regions, leaving satellite basemaps stale and motivating synthesis of satellite imagery from independently maintained cartographic data. Existing ControlNet-based diffusion methods typically condition on structural signals like edges or segmentation extracted from the target image itself, assuming the imagery already exists and limiting their use exactly where synthesis matters most. Map-conditioned alternatives add cues like edge detection but omit frequency-domain structure. We propose a ControlNet-based diffusion framework conditioned only on cartographic sources obtainable independently of the target imagery: OpenStreetMap (OSM) raster maps and their stationary wavelet transform (SWT) subbands, a conditioning signal previously unexplored for map-to-satellite diffusion. Two ControlNet adapters, trained separately on the map and wavelet representations atop a frozen Stable Diffusion backbone, are fused via MultiControlNet, jointly drawing on spatial structure and frequency detail without retraining a multi-input model. We evaluate on a new paired map-satellite dataset curated for Nepal, a data-scarce, topographically diverse region, alongside the Pix2Pix maps-satellite benchmark. Combined conditioning wins six of eight metric-dataset comparisons -- SSIM and PSNR on both datasets, plus LPIPS (both Alex and VGG backbones) on ours and ties map-only on both Pix2Pix LPIPS backbones while still edging past wavelet-only there. Wavelet-only takes the lowest FID on both datasets, matching the tradeoff between per-image fidelity and distributional realism. We treat this gap cautiously given our modest test-set sizes and FID's known small-sample bias.

The vast chemical design space and complex, interdependent design variables make catalyst discovery for targeted properties highly labor- and resource-intensive. Although generative models have emerged as a promising solution, existing approaches are generally limited to single-property conditioning or narrow chemical spaces. Here, we present Catalyst Diffusion Transformer (CatDiT), a unified framework for inverse catalyst design that generates valid and novel structures ranging from intermetallic alloys to oxide surfaces. By learning compressed latent representations, CatDiT enables efficient training and rapid sampling while supporting simultaneous conditioning on adsorbate type, binding energy, and catalyst class. The model provides reliable control of discrete properties and directional control of continuous properties, enriching candidate pools for reaction-specific catalyst discovery. As a representative application, multi-conditional generation for the nitrogen reduction reaction (NRR) yields 28 density functional theory (DFT)-relaxed alloy candidates that satisfy the target activity window and lie above the pure-metal *N-*H scaling line, corresponding to a ~1.5-fold enrichment over the source distribution. These results establish CatDiT as a practical and scalable approach for property-directed catalyst inverse design and targeted catalyst generation.

Thermal-to-visible face translation presents fundamental challenges including geometric discontinuities, semantic attribute mismatches, and identity degradation. We propose MTVDiff, a novel multimodal latent diffusion framework that synergistically integrates depth and textual information to address these limitations while preserving identity characteristics. The MTVDiff framework presents three core technical contributions: (1) a Dual-Branch Cross-Attention Fusion (DBCAF) module for multi-scale thermal-depth feature extraction and fusion; (2) a Gated Text-to-Visual Feature Alignment mechanism for semantically-guided generation; and (3) Spatial Feature Transformations (SFT) for adaptive multimodal prior integration. Extensive experiments on the MCXFace and SpeakingFaces datasets demonstrate that our multimodal approach significantly outperforms existing GAN-based and diffusion-based approaches across multiple metrics, achieving substantial improvements in both image quality and face verification performance, with FID reductions of up to 48.3% and Rank-1 accuracy improvements of up to 8.9%. Our work provides a robust solution for face recognition systems operating under varying illumination conditions and advances the state-of-the-art in cross-spectral facial image translation through effective multimodal integration.

Conditional diffusion models have become a powerful and flexible framework for learning complex conditional distributions from labeled data. In practice, however, acquiring high-quality labels is costly and time-consuming, leaving large volumes of unlabeled data unused. To address this, we introduce label-augmented conditional diffusion (LACD), a simple and effective approach that incorporates unlabeled examples by assigning them a designated trivial label and performing joint denoising score matching over the augmented dataset. We provide sufficient conditions guaranteeing population-level identifiability of the target conditional distribution under this scheme. Moreover, we establish rigorous statistical guarantees: when sufficiently many unlabeled samples are available, the sampling distribution produced by LACD converges strictly faster than the purely supervised estimator in total variation distance, and at least as fast in Wasserstein-1 distance. Extensive experiments on synthetic, image, and tabular benchmarks corroborate our theory and show substantial gains in sample efficiency and generative performance compared with the purely supervised estimator.

Accurate routability estimation during physical design is important for reducing costly post-routing iterations. Prior learning-based methods treat this task as deterministic prediction, mapping placement-stage features to a single congestion or DRC outcome. We instead formulate routability estimation as a conditional generation problem, where both routing congestion and DRC violations are modeled as spatially structured routability fields. Our framework, Conditional Latent Diffusion for Routeability estimation (CLDRoute), uses physics-aware conditioning and task-specific latent modeling to handle the different characteristics of congestion and DRC maps. This allows our method to supports sample-based inference, producing both a mean prediction and a spatial uncertainty estimate for the same input design. On CircuitNet 2.0 (N28), our method achieves, for DRC violation generation, an SSIM of 0.9678, an MAE of 0.0028, and a TopK@1% of 0.3494; for congestion generation, it achieves an SSIM of 0.9031, an MAE of 0.0286, and an NZ-Pearson of 0.3692. Overall, our framework provides a more practical view of routability at placement by generating both the expected outcome and its uncertainty.

Weakly-supervised RGB-D Salient Object Detection (SOD) is explored to reduce the heavy burden of pixel-level annotations. But scribble annotations lack the structure and details of objects, resulting in inaccurate saliency maps. In this paper, we propose a novel scribble-supervised RGB-D SOD method, consisting of a Segment Anything Model (SAM)-driven pseudo annotation generation method (\emph{SAM-PAG}) and a state space interaction-based conditional diffusion model (\emph{$S^2$Diff}). Specifically, SAM-PAG is tailored to address the issue of sparse supervision information. In SAM-PAG, we adopt the advanced SAM to expand sparse scribbles to dense pixel-level pseudo annotations through the dual-branch structure and the consistency of segmentation masks. In $S^2$Diff, we adopt the diffusion model to iteratively refine the noisy saliency maps with the guidance of conditional information, generating accurate saliency maps. Naturally, the core of our $S^2$Diff lies in the acquisition of conditional features and the denoising of saliency maps. For the former, we employ a cross-modal conditional generation module to interweave cross-modal features through frequency integration and implicit-explicit state space interaction, effectively achieving global conditional features. For the latter, we employ a context injection module to mitigate noise interference and to enhance object information with the conditional context. With the close cooperation of SAM-PAG and $S^2$Diff, our method outperforms relevant scribble-supervised methods and achieves competitive performance compared to fully-supervised methods on seven datasets. The code and results of our method are available at https://github.com/Switch457/WeakS2Diff_SOD.

Sign language production, which generates continuous 3D skeletal motion from spoken language input, must simultaneously satisfy two constraints: semantic fidelity, so that a deaf viewer can recognize the intended sequence of glosses, and biomechanical plausibility, so that the generated skeleton respects anatomical constraints. Existing approaches optimize semantic reconstruction through coordinate-based objectives that treat the skeleton as an unstructured vector, thus allowing for bone length drift, joint angle violations, and temporarily locked fingers. We introduce PIDiffSign, a physics-informed diffusion model for gloss-to-pose translation that incorporates anatomical constraints into both the architecture and training objective. The model uses a Transformer encoder-decoder, where the decoder is conditioned on the diffusion time step through adaptive zero-initialized layer normalization and cross-attends to gloss representations. A differentiable geometry module enforces bone length consistency and biologically valid joint angles throughout generation. Training combines anthropomorphic, kinematic, angular, and finger-joint constraints with a contrastive gloss-pose alignment loss and classifier-free guidance for semantically conditioned sampling. Experiments on the PHOENIX14T and CSL-Daily benchmarks show consistent improvements over a strong diffusion baseline in pose accuracy, joint-angle correctness, distributional realism, and back-translation quality. These results demonstrate that physics-informed diffusion improves both motion realism and semantic fidelity for sign language generation.

We present a diffusion based model for asynchronous time series prediction, where the goal is to predict the next inter event time and event type. To address the inherent uncertainty of future events, we introduce ReDiTT, a retrieval augmented conditional diffusion transformer that operates in latent space. ReDiTT retrieves structurally similar latent sequences from a memory bank during both training and inference and incorporates them as reference conditions through cross attention. This retrieval based conditioning allows the model to attend to relevant temporal dynamics and provides global structural guidance for generation. As a result, ReDiTT stabilizes long horizon forecasting and improves sample diversity. Experiments on seven real world datasets demonstrate state of the art performance on next event prediction and long horizon forecasting. Our code is available at https://github.com/BorealisAI/ReDiTT.

Drug discovery and development is time-consuming and resource-intensive, motivating computational approaches such as diffusion models for de novo drug design. Many such models follow the structure-based drug design (SBDD) paradigm, generating molecules to fit a target binding pocket. However, existing diffusion-based SBDD methods typically couple pocket and ligand representation learning, model interactions only at the atom level, and prioritize binding affinity over other developability properties. Here, we introduce conDitar-dev, a conditional diffusion-based SBDD framework for generating ligands with strong binding affinities and favorable ADMET properties. It consists of three modules: msPRL, a pretrained multi-scale pocket representation learning module; conDitar, a pocket-conditioned diffusion model guided by msPRL representations; and paOPT, a generation-time method for optimizing ligand developability. On a newly curated benchmark of human disease targets, conDitar outperforms state-of-the-art SBDD baselines, achieving an average binding score of -8.85 kcal/mol. Across five ADMET properties, conDitar-dev improves performance by up to 73% over conDitar. To further validate the abilities of conDitar-dev to generate developable molecules, we have applied it to two validated druggable targets: programmed death-ligand 1 (PD-L1) and colony-stimulating factor 1 receptor (CSF1R) proteins. Top-ranked generatively designed molecules and their analogs have been experimentally synthesized and biologically tested. Two molecules generated directly by conDitar-dev for PD-L1 exhibited SPR-derived $K_D$ values of 3.49 and 3.75 $μ$M, respectively. Hit expansion based on conDitar-dev-designed molecules identified selective CSF1R inhibitors with IC$_{50}$ values as low as 200 nM, while also uncovering opportunities for drug repositioning.

Conditional diffusion models can generate anatomically plausible medical ultrasound (US) images, but anatomical plausibility alone does not ensure realistic B-mode appearance. Most US pipelines adapt standard generative architectures and condition them on anatomical masks, or use guidance mechanisms that reinforce the same anatomical signal. However, B-mode US images are shaped by acquisition-dependent properties such as speckle texture, tissue contrast, and attenuation. Using a frozen US foundation model, we show that standard conditional diffusion baselines remain separated from real images in representation space. In this work, we propose Feature-Space Candidate Guidance (FSCG), a training-free sampling strategy to reduce this gap. At sampling time, FSCG applies local k-NN feature correction and selects the best of multiple stochastic candidates according to their feature-space energy. In this way, the mask defines the anatomy, while FSCG steers samples toward the real US domain. Across three different datasets, FSCG reduces average FID64 by 56%, FID192 by 57%, and nearest-neighbour feature distance by 47% over standard conditional diffusion sampling, outperforming alternative inference-time guidance baselines. The results suggest that domain-aware feature representations can reveal and reduce realism gaps in medical diffusion synthesis without retraining the generator. Our code is available at https://github.com/marinadominguez/FSCG.

Hairstyle transfer aims to synthesize a photorealistic portrait by transplanting the hairstyle from a reference image onto a source subject while preserving the source identity. Recent foundation models show strong generative capability, but they struggle with the zero-shot disentanglement required for precise local editing, often entangling the reference hairstyle with its original identity and pose. Existing diffusion-based pipelines typically decompose the task by first generating a "bald" image from the source and then injecting hairstyle features from the reference. However, we show that this paradigm suffers from a fundamental leakage problem. Identity Leakage in Hairstyle occurs when hairstyle features retain reference identity or pose information, while Flaw Leakage in Bald arises when residual artifacts in the bald image are propagated into the final synthesis. To address both issues, we propose the Dual-Purification Framework (DPF), which introduces two complementary training-time regularizers. Adversarial Hairstyle Purification (AHP) purifies hairstyle features by suppressing identity predictability under a mutual-information-inspired adversarial objective. Contrastive Geometric Purification (CGP) regularizes the ControlNet pathway with a contrastive objective, reducing the model's reliance on geometric artifacts in the bald condition. By jointly purifying the hairstyle representation and geometric pathway, DPF achieves high-fidelity, identity-preserving hairstyle transfer and state-of-the-art performance on diverse benchmarks.

Computed tomography (CT) is a critical imaging modality for clinical diagnosis, but reducing radiation dose inevitably introduces severe noise and structured artifacts that degrade image quality. Existing deep learning-based low-dose CT (LDCT) reconstruction methods are typically optimized for fixed dose levels or specific anatomical regions, limiting their robustness and generalization in realistic clinical settings. We propose GenDiff, a generalizable diffusion-based framework for LDCT reconstruction that jointly models continuous radiation dose and anatomical information within a unified reconstruction network. The proposed framework integrates a Dose-Anatomy Encoder to learn acquisition-aware embeddings, a dose- and anatomy-conditioned cold diffusion backbone for iterative refinement, a physics-consistency update to enforce fidelity to the CT forward model, and a Structural Prior Refinement Module (SPRM) that preserves anatomical structures while suppressing dose-dependent artifacts. Extensive experiments on multi-anatomy clinical datasets, including unseen ultra-low-dose conditions as well as out-of-distribution phantom and animal datasets, demonstrate that GenDiff consistently outperforms state-of-the-art convolutional neural network and diffusion-based reconstruction methods. The proposed approach achieves superior reconstruction quality while maintaining strong robustness across different dose levels, anatomical regions, and acquisition domains, making it a promising solution for practical low-dose CT imaging.

Personalizing exoskeleton assistance requires user-specific gait data across many locomotor tasks, yet collecting this data demands repeated motion capture sessions that are costly, time-intensive, and especially burdensome for clinical populations. This challenge is most acute across walking speeds, where gait changes substantially and deviates further in clinical gait. This work introduces a subject-conditioned residual diffusion framework that generates personalized lower-limb kinematics at unseen walking speeds from a subject's gait sequence at a single seen speed. Given sagittal-plane hip, knee, and ankle trajectories at a seen speed and a desired unseen speed, the model generates a residual that transforms the seen trajectory into the unseen one, using a transformer denoiser conditioned on the subject's gait and the two speeds through feature-wise linear modulation. Trained only on able-bodied data, the model achieved a mean absolute error (MAE) of 3.4° on held-out able-bodied subjects. Without any stroke-specific fine-tuning, it achieved a 6.0° MAE on out-of-training-distribution stroke subjects, retaining subject identity for clinical gait. The framework reduced the MAE by over 70% relative to supervised feed-forward baselines, and a single seen speed matched the accuracy of four speeds within 0.4°. These results demonstrate that subject-conditioned residual diffusion can synthesize personalized gait across speeds from minimal data, reducing the collection burden for downstream exoskeleton personalization.

Sampling stochastic signals supported on a graph underlies many graph machine learning tasks, including recommender systems, forecasting in financial markets, and wireless network optimization. In these settings, the target signals are realizations of unknown conditional distributions. However, prevailing approaches rely mostly on intricate, application-tailored designs that often regress to a conditional mean instead of sampling from the conditional law. This paper unifies such problems as conditional graph signal generative modeling and tackles them with a single denoising diffusion framework. We learn a reverse diffusion process, parametrized by graph neural networks (GNNs), that draws graph signals conditioned directly on the graph topology and on node-feature side information. The reverse process is realized by a novel architecture, the U-Graph Neural Network (U-GNN), which generalizes the image-convolutional U-Net to graph-structured signals. The U-GNN performs multi-resolution encoder--decoder processing in which pooling and unpooling reduce to a learned node selection, expressed by nested selection matrices, and a zero-padded lifting of coarse signals back to the full node set. The graph convolutions are carried out on the original graph, with a stride that sets their hop reach, so the U-GNN bypasses explicit graph coarsening at every resolution. We demonstrate our method on two generative tasks: stock price forecasting and optimal wireless resource allocation, with extensive numerical results in both domains.

Seismic wavefield simulation is fundamental to seismology, but conventional finite-difference (FD) methods remain limited by numerical dispersion and stability constraints, which often require dense spatial grids and small time steps and thereby severely limit the effectiveness of iterative inversion workflows. We introduce a conditional diffusion-based wavefield propagator that advances seismic wavefields recursively from one time step to the next. Instead of learning an unconditional data distribution of wavefield evolution, the model is conditioned by a short history of recent wavefield time steps (snapshots), the velocity model, and the wavefield time step index, allowing it to represent the conditional transition between adjacent physical states. By training the network to directly predict the clean next wavefield snapshot, this strong physical conditioning makes it possible to replace the iterative reverse diffusion process with a single network evaluation for each predicted snapshot. To improve stability over long recursive rollouts, we further introduce a causal time-weighted loss, in which adaptive weights, accumulated as exponential moving averages of per-snapshot training errors, emphasize training directions that are consistent with the forward propagation sequence and reduce the amplification of one-step prediction errors. Because the learned propagator is tied to the temporal spacing of the training snapshots rather than to the FD stability limit, it can advance the wavefield using a physical time step ten times larger than that required by the underlying solver. Experiments on the Overthrust, SEG/EAGE, and Marmousi models show that the proposed method accurately reproduces wavefield snapshots and shot gathers and achieves an end-to-end speedup of 2.17 x over a GPU-accelerated tenth-order staggered-grid FD implementation under matched hardware conditions.

Existing Salient Object Detection in Optical Remote Sensing Image (ORSI-SOD) methods mainly adopt the static inference strategy, which uses fixed trained model parameters for saliency inference in the testing phase. This means that even if the generated saliency map has errors, it cannot be further optimized. In this paper, we propose the novel IPDiff, a Diffusion-driven ORSI-SOD method with Information Reconstruction and Multi-Prior Guidance. We build IPDiff based on a unique dynamic optimization strategy, which endows IPDiff with the ability to iteratively optimize saliency maps with a dynamic parameter. Specifically, we formulate ORSI-SOD as a conditional diffusion problem in IPDiff. IPDiff first extracts informative conditional priors from ORSIs, including the saliency prior and the hierarchical priors, in the prior network with the assistance of the information reconstruction-driven attention module. The saliency prior can provide positional information of salient objects, while the hierarchical priors can provide specific detail and semantic information of salient objects. Under the guidance of these priors, IPDiff then iteratively denoises random noise as the timestep dynamically changes in the denoising network, generating saliency maps that are close to ground truths. Notably, we simultaneously supervise IPDiff in both spatial and spectral domains through a hybrid loss function to achieve efficient network training. Comprehensive experiments on public ORSSD, EORSSD, and ORSI-4199 datasets demonstrate that our proposed IPDiff achieves the best performance compared to 46 state-of-the-art methods. The code and results of our method are available at https://github.com/MathLee/IPDiff.

Controllable generative models of 3D medical images can synthesize volumes with specified clinical attributes, but this demands samples that are simultaneously high-fidelity, natively 3D, and faithful to the requested conditioning. We present CONFLUX, a latent diffusion model for chest computed tomography (CT): a 3D variational autoencoder compresses each volume, and a rectified-flow transformer generates in the latent space. Generation is conditioned on structured radiological metadata (18 abnormality findings, sex, age, and reconstruction kernel) through adaptive layer normalization. The model leads strong volumetric baselines on tri-planar Frechet distance (FID 32.3 vs. 74.6 for MAISI) while exposing direct control over clinical attributes. To strengthen that control we add an online reinforcement-learning post-training stage (group-relative policy optimization) that rewards how reliably a classifier recovers the requested findings from each generated volume. Judged by a separate, independent classifier, post-training removes 47% of the shortfall relative to real-scan reliability. We release the model and a ~200k synthetic chest-CT dataset with conditioning metadata spanning a wide variety of clinical findings.

Salient Object Detection in underwater images remains challenging due to low contrast, uneven illumination, and color distortion caused by scattering and absorption effects, which limit the effectiveness of conventional SOD methods in underwater environments. To address these challenges, we propose a Degradation-aware Conditional Generation Network (DCGNet), specifically designed to construct reliable conditional features for underwater saliency generation. First, we design a Dynamic Multi-Granularity module (DMG) grounded in the human visual system to robustly detect salient objects of varying scales with blurred boundaries. Then, we develop an Underwater Physics-Prior module (UPP), which utilizes pseudo-depth guidance to estimate underwater light attenuation and backscatter, thereby restoring degradation-aware RGB features and mitigating color distortion and boundary ambiguity. Based on the physics-guided representation, we introduce an Underwater Spatial Gaussian module (USG), which constructs a spatial Gaussian saliency prior from the strongest guided response to enhance object-centered salient regions and suppress cluttered underwater backgrounds. In addition, a lightweight timestep-adaptive Diffusion Transformer (DiT) bottleneck is inserted into the denoising decoder to refine fused features at different diffusion timesteps. Comprehensive experiments on USOD10K, USOD, CSOD10K, MAS3K, and RMAS demonstrate that DCGNet significantly outperforms existing state-of-the-art methods, verifying its potential for complex underwater visual applications.

Reconstruction-based generative models offer a natural framework for unsupervised out-of-distribution (OOD) detection, but multi-class normality modelling requires a single detector to capture multiple in-distribution manifolds and produce comparable anomaly scores across classes. We study this problem in copy detection pattern (CDP) authentication, where authentic and counterfeit samples are visually similar but differ in subtle printing-and-digitisation (P&D) signatures. We propose a diffusion based multi-class normality framework in which a single class-conditional ControlNet is trained exclusively on authentic CDPs from multiple P&D classes and detects counterfeits through reconstruction error under authentic-class conditioning. We further introduce dual template masking, which hides complementary regions of the input template and scores only withheld pixels, reducing reliance on visible binary structure. On the Indigo 1 x 1 Base dataset, the proposed method outperforms traditional and adapted generative baselines under multi-class authentic-versus-counterfeit evaluation, without using counterfeit samples for training or threshold calibration.

Synthetic data generation has emerged as a powerful tool for improving data scalability in computer vision. Recent diffusion-based pipelines have demonstrated strong photorealism. However, how to enforce precise 3D structure and pose consistency in generated images remains challenging. Existing methods leverage visual prompts such as edge maps to guide diffusion models, but often suffer from over-conditioning artifacts that degrade image realism and limit dataset quality. In this paper, we present a diffusion-based image generation framework that enforces 3D structural alignment while preserving photorealism through adaptive conditioning. Our framework, Adaptive Conditioning for 3D-Aware Synthetic Data Generation (AC3S), introduces a self-supervised visual prompt modulator that dynamically adjusts the strength of ControlNet conditioning, preventing over-conditioning and enabling the diffusion model to retain its generative expressiveness. To further enhance diversity and semantic consistency, we develop a multi-agent vision language model framework that composes detailed and 3D-aware prompts aligned with the underlying geometric structure. Together, these components enable the scalable generation of high-quality synthetic datasets with accurate 2D and 3D annotations. Extensive experiments demonstrate that our method significantly improves image quality and downstream utility.

Recent progress in Text-to-Image generation benefits from large-scale Text-Image pairs. However, the scarcity of Text-LiDAR pairs often causes over-smoothed scenes and limited controllability. In this paper, we rethink the limitations of Text-LiDAR generation task, focusing on alleviating insufficient training priors and constructing controllable Text-LiDAR data. We propose a \textbf{T}ext-\textbf{to}-\textbf{L}iDAR \textbf{D}iffusion \textbf{M}odel for LiDAR scene generation, T2LDM++, with a Self-Conditioned Representation Guidance (SCRG). Specifically, to alleviate object over-smoothing, SCRG employs a Guidance Network (GN) to provide reconstruction-based soft supervision to the Denoising Network (DN). This enables DN to learn geometry-aware representations through reconstruction guidance, leading to more accurate denoising in DDPMs. Meanwhile, through analysis and design, SCRG exhibits more effective and lightweight, while decoupled in inference, avoiding computational overhead. Furthermore, we construct two high-quality Text-LiDAR benchmarks ($>$100K samples) using a generalized strategy of geometric annotations, along with a controllability metric. Moreover, a directional position prior is designed to mitigate street distortion, further improving scene fidelity. Additionally, T2LDM++ supports multiple conditions, including (Semantic, Box, BEV, Camera)-to-LiDAR, Sparse-to-Dense, and Dense-to-Sparse generation, by learning a control encoder via frozen DN. With effective prior modeling and high-quality Text-LiDAR benchmarks, T2LDM++ can generate realistic LiDAR scenes with rich geometric details in unconditional and conditional settings.