Missing-Modality Learning

Multimodal medical image segmentation often faces missing modalities at inference, which induces disagreement among modality experts and makes fusion unstable, particularly on small foreground structures. We propose Consistency Learning of Experts (CLoE), a consistency-driven framework for missing-modality segmentation that preserves strong performance when all modalities are available. CLoE formulates robustness as decision-level expert consistency control and introduces a dual-branch Expert Consistency Learning objective. Modality Expert Consistency enforces global agreement among expert predictions to reduce case-wise drift under partial inputs, while Region Expert Consistency emphasizes agreement on clinically critical foreground regions to avoid background-dominated regularization. We further map consistency scores to modality reliability weights using a lightweight gating network, enabling reliability-aware feature recalibration before fusion. Extensive experiments on BraTS 2020 and MSD Prostate demonstrate that CLoE outperforms state-of-the-art methods in incomplete multimodal segmentation, while exhibiting strong cross-dataset generalization and improving robustness on clinically critical structures.

Multimodal Sentiment Analysis (MSA) seeks to infer human emotions by integrating textual, acoustic, and visual cues. However, existing approaches often rely on all modalities are completeness, whereas real-world applications frequently encounter noise, hardware failures, or privacy restrictions that result in missing modalities. There exists a significant feature misalignment between incomplete and complete modalities, and directly fusing them may even distort the well-learned representations of the intact modalities. To this end, we propose PRLF, a Progressive Representation Learning Framework designed for MSA under uncertain missing-modality conditions. PRLF introduces an Adaptive Modality Reliability Estimator (AMRE), which dynamically quantifies the reliability of each modality using recognition confidence and Fisher information to determine the dominant modality. In addition, the Progressive Interaction (ProgInteract) module iteratively aligns the other modalities with the dominant one, thereby enhancing cross-modal consistency while suppressing noise. Extensive experiments on CMU-MOSI, CMU-MOSEI, and SIMS verify that PRLF outperforms state-of-the-art methods across both inter- and intra-modality missing scenarios, demonstrating its robustness and generalization capability.

Collaborative perception integrates multi-agent perspectives to enhance the sensing range and overcome occlusion issues. While existing multimodal approaches leverage complementary sensors to improve performance, they are highly prone to failure--especially when a key sensor like LiDAR is unavailable. The root cause is that feature fusion leads to semantic mismatches between single-modality features and the downstream modules. This paper addresses this challenge for the first time in the field of collaborative perception, introducing Single-Modality-Operable Multimodal Collaborative Perception (SiMO). By adopting the proposed Length-Adaptive Multi-Modal Fusion (LAMMA), SiMO can adaptively handle remaining modal features during modal failures while maintaining consistency of the semantic space. Additionally, leveraging the innovative "Pretrain-Align-Fuse-RD" training strategy, SiMO addresses the issue of modality competition--generally overlooked by existing methods--ensuring the independence of each individual modality branch. Experiments demonstrate that SiMO effectively aligns multimodal features while simultaneously preserving modality-specific features, enabling it to maintain optimal performance across all individual modalities. The implementation details can be found in https://github.com/dempsey-wen/SiMO.

Emotion recognition in real-world environments is hindered by partial occlusions, missing modalities, and severe class imbalance. To address these issues, particularly for the Affective Behavior Analysis in-the-wild (ABAW) Expression challenge, we propose a multimodal framework that dynamically fuses visual and audio representations. Our approach uses a dual-branch Transformer architecture featuring a safe cross-attention mechanism and a modality dropout strategy. This design allows the network to rely on audio-based predictions when visual cues are absent. To mitigate the long-tail distribution of the Aff-Wild2 dataset, we apply focal loss optimization, combined with a sliding-window soft voting strategy to capture dynamic emotional transitions and reduce frame-level classification jitter. Experiments demonstrate that our framework effectively handles missing modalities and complex spatiotemporal dependencies, achieving an accuracy of 60.79% and an F1-score of 0.5029 on the Aff-Wild2 validation set.

Accurate brain tumor typing requires integrating heterogeneous clinical evidence, including magnetic resonance imaging (MRI), histopathology, and pathology reports, which are often incomplete at the time of diagnosis. We introduce CoRe-BT, a cross-modal radiology-pathology-text benchmark for brain tumor typing, designed to study robust multimodal learning under missing modality conditions. The dataset comprises 310 patients with multi-sequence brain MRI (T1, T1c, T2, FLAIR), including 95 cases with paired H&E-stained whole-slide pathology images and pathology reports. All cases are annotated with tumor type and grade, and MRI volumes include expert-annotated tumor masks, enabling both region-aware modeling and auxiliary learning tasks. Tumors are categorized into six clinically relevant classes capturing the heterogeneity of common and rare glioma subtypes. We evaluate tumor typing under variable modality availability by comparing MRI-only models with multimodal approaches that incorporate pathology information when present. Baseline experiments demonstrate the feasibility of multimodal fusion and highlight complementary modality contributions across clinically relevant typing tasks. CoRe-BT provides a grounded testbed for advancing multimodal glioma typing and representation learning in realistic scenarios with incomplete clinical data.

Multimodal data encountered in real-world scenarios are typically of low quality, with noisy modalities and missing modalities being typical forms that severely hinder model performance and robustness. However, prior works often handle noisy and missing modalities separately. In contrast, we jointly address missing and noisy modalities to enhance model robustness in low-quality data scenarios. We regard both noisy and missing modalities as a unified low-quality modality problem, and propose a unified modality-quality (UMQ) framework to enhance low-quality representations for multimodal affective computing. Firstly, we train a quality estimator with explicit supervised signals via a rank-guided training strategy that compares the relative quality of different representations by adding a ranking constraint, avoiding training noise caused by inaccurate absolute quality labels. Then, a quality enhancer for each modality is constructed, which uses the sample-specific information provided by other modalities and the modality-specific information provided by the defined modality baseline representation to enhance the quality of unimodal representations. Finally, we propose a quality-aware mixture-of-experts module with particular routing mechanism to enable multiple modality-quality problems to be addressed more specifically. UMQ consistently outperforms state-of-the-art baselines on multiple datasets under the settings of complete, missing, and noisy modalities.

Multimodal semantic segmentation integrates complementary information from diverse sensors for remote sensing Earth observation. However, practical systems often encounter missing modalities due to sensor failures or incomplete coverage, termed Incomplete Multimodal Semantic Segmentation (IMSS). IMSS faces three key challenges: (1) multimodal imbalance, where dominant modalities suppress fragile ones; (2) intra-class variation in scale, shape, and orientation across modalities; and (3) cross-modal heterogeneity with conflicting cues producing inconsistent semantic responses. Existing methods rely on contrastive learning or joint optimization, which risk over-alignment, discarding modality-specific cues or imbalanced training, favoring robust modalities, while largely overlooking intra-class variation and cross-modal heterogeneity. To address these limitations, we propose the Semantic-Guided Modality-Aware (SGMA) framework, which ensures balanced multimodal learning while reducing intra-class variation and reconciling cross-modal inconsistencies through semantic guidance. SGMA introduces two complementary plug-and-play modules: (1) Semantic-Guided Fusion (SGF) module extracts multi-scale, class-wise semantic prototypes that capture consistent categorical representations across modalities, estimates per-modality robustness based on prototype-feature alignment, and performs adaptive fusion weighted by robustness scores to mitigate intra-class variation and cross-modal heterogeneity; (2) Modality-Aware Sampling (MAS) module leverages robustness estimations from SGF to dynamically reweight training samples, prioritizing challenging samples from fragile modalities to address modality imbalance. Extensive experiments across multiple datasets and backbones demonstrate that SGMA consistently outperforms state-of-the-art methods, with particularly significant improvements in fragile modalities.

Multi-modal 3D object detection is pivotal for autonomous driving, integrating complementary sensors like LiDAR and cameras. However, its real-world reliability is challenged by transient data interruptions and missing, where modalities can momentarily drop due to hardware glitches, adverse weather, or occlusions. This poses a critical risk, especially during a simultaneous modality drop, where the vehicle is momentarily blind. To address this problem, we introduce ModalPatch, the first plug-and-play module designed to enable robust detection under arbitrary modality-drop scenarios. Without requiring architectural changes or retraining, ModalPatch can be seamlessly integrated into diverse detection frameworks. Technically, ModalPatch leverages the temporal nature of sensor data for perceptual continuity, using a history-based module to predict and compensate for transiently unavailable features. To improve the fidelity of the predicted features, we further introduce an uncertainty-guided cross-modality fusion strategy that dynamically estimates the reliability of compensated features, suppressing biased signals while reinforcing informative ones. Extensive experiments show that ModalPatch consistently enhances both robustness and accuracy of state-of-the-art 3D object detectors under diverse modality-drop conditions.

Adapting Large Multimodal Models (LMMs) to real-world scenarios poses the dual challenges of learning from sequential data streams while handling frequent modality incompleteness, a task known as Continual Missing Modality Learning (CMML). However, existing works on CMML have predominantly relied on prompt tuning, a technique that struggles with this task due to cross-task interference between its learnable prompts in their shared embedding space. A naive application of Low-Rank Adaptation (LoRA) with modality-shared module will also suffer modality interference from competing gradients. To this end, we propose DeLo, the first framework to leverage a novel dual-decomposed low-rank expert architecture for CMML. Specifically, this architecture resolves modality interference through decomposed LoRA expert, dynamically composing LoRA update matrix with rank-one factors from disentangled modality-specific factor pools. Embedded within a task-partitioned framework that structurally prevents catastrophic forgetting, this expert system is supported by two key mechanisms: a Cross-Modal Guided Routing strategy to handle incomplete data and a Task-Key Memory for efficient, task-agnostic inference. Extensive experiments on established CMML benchmarks demonstrate that our method significantly outperforms state-of-the-art approaches. This highlights the value of a principled, architecturally-aware LoRA design for real-world multimodal challenges.

Multimodal sentiment analysis in federated learning environments faces significant challenges due to missing modalities, heterogeneous data distributions, and unreliable client updates. Existing federated approaches often struggle to maintain robust performance under these practical conditions. In this paper, we propose FedUAF, a unified multimodal federated learning framework that addresses these challenges through uncertainty-aware fusion and reliability-guided aggregation. FedUAF explicitly models modality-level uncertainty during local training and leverages client reliability to guide global aggregation, enabling effective learning under incomplete and noisy multimodal data. Extensive experiments on CMU-MOSI and CMU-MOSEI demonstrate that FedUAF consistently outperforms state-of-the-art federated baselines across various missing-modality patterns and Non-IID settings. Moreover, FedUAF exhibits superior robustness against noisy clients, highlighting its potential for real-world multimodal federated applications.

Machine learning holds promise for advancing clinical decision support, yet it remains unclear when multimodal learning truly helps in practice, particularly under modality missingness and fairness constraints. In this work, we conduct a systematic benchmark of multimodal fusion between Electronic Health Records (EHR) and chest X-rays (CXR) on standardized cohorts from MIMIC-IV and MIMIC-CXR, aiming to answer four fundamental questions: when multimodal fusion improves clinical prediction, how different fusion strategies compare, how robust existing methods are to missing modalities, and whether multimodal models achieve algorithmic fairness. Our study reveals several key insights. Multimodal fusion improves performance when modalities are complete, with gains concentrating in diseases that require complementary information from both EHR and CXR. While cross-modal learning mechanisms capture clinically meaningful dependencies beyond simple concatenation, the rich temporal structure of EHR introduces strong modality imbalance that architectural complexity alone cannot overcome. Under realistic missingness, multimodal benefits rapidly degrade unless models are explicitly designed to handle incomplete inputs. Moreover, multimodal fusion does not inherently improve fairness, with subgroup disparities mainly arising from unequal sensitivity across demographic groups. To support reproducible and extensible evaluation, we further release a flexible benchmarking toolkit that enables plug-and-play integration of new models and datasets. Together, this work provides actionable guidance on when multimodal learning helps, when it fails, and why, laying the foundation for developing clinically deployable multimodal systems that are both effective and reliable. The open-source toolkit can be found at https://github.com/jakeykj/CareBench.

Missing modalities present a fundamental challenge in multimodal models, often causing catastrophic performance degradation. Our observations suggest that this fragility stems from an imbalanced learning process, where the model develops an implicit preference for certain modalities, leading to the under-optimization of others. We propose a simple yet efficient method to address this challenge. The central insight of our work is that the dominance relationship between modalities can be effectively discerned and quantified in the frequency domain. To leverage this principle, we first introduce a Frequency Ratio Metric (FRM) to quantify modality preference by analyzing features in the frequency domain. Guided by FRM, we then propose a Multimodal Weight Allocation Module, a plug-and-play component that dynamically re-balances the contribution of each branch during training, promoting a more holistic learning paradigm. Extensive experiments demonstrate that MWAM can be seamlessly integrated into diverse architectural backbones, such as those based on CNNs and ViTs. Furthermore, MWAM delivers consistent performance gains across a wide range of tasks and modality combinations. This advancement extends beyond merely optimizing the performance of the base model; it also manifests as further performance improvements to state-of-the-art methods addressing the missing modality problem.

Synthesizing missing modalities in multi-modal magnetic resonance imaging (MRI) is vital for ensuring diagnostic completeness, particularly when full acquisitions are infeasible due to time constraints, motion artifacts, and patient tolerance. Recent unified synthesis models have enabled flexible synthesis tasks by accommodating various input-output configurations. However, their training and evaluation are typically restricted to a single dataset, limiting their generalizability across diverse clinical datasets and impeding practical deployment. To address this limitation, we propose PMM-Synth, a personalized MRI synthesis framework that not only supports various synthesis tasks but also generalizes effectively across heterogeneous datasets. PMM-Synth is jointly trained on multiple multi-modal MRI datasets that differ in modality coverage, disease types, and intensity distributions. It achieves cross-dataset generalization through three core innovations: a Personalized Feature Modulation module that dynamically adapts feature representations based on dataset identifier to mitigate the impact of distributional shifts; a Modality-Consistent Batch Scheduler that facilitates stable and efficient batch training under inconsistent modality conditions; and a selective supervision loss to ensure effective learning when ground truth modalities are partially missing. Evaluated on four clinical multi-modal MRI datasets, PMM-Synth consistently outperforms state-of-the-art methods in both one-to-one and many-to-one synthesis tasks, achieving superior PSNR and SSIM scores. Qualitative results further demonstrate improved preservation of anatomical structures and pathological details. Additionally, downstream tumor segmentation and radiological reporting studies suggest that PMM-Synth holds potential for supporting reliable diagnosis under real-world modality-missing scenarios.

Action Quality Assessment (AQA) aims to score how well an action is performed and is widely used in sports analysis, rehabilitation assessment, and human skill evaluation. Multi-modal AQA has recently achieved strong progress by leveraging complementary visual and kinematic cues, yet real-world deployments often suffer from non-stationary modality imbalance, where certain modalities become missing or intermittently available due to sensor failures or annotation gaps. Existing continual AQA methods overlook this issue and assume that all modalities remain complete and stable throughout training, which restricts their practicality. To address this challenge, we introduce Bridged Modality Adaptation (BriMA), an innovative approach to multi-modal continual AQA under modality-missing conditions. BriMA consists of a memory-guided bridging imputation module that reconstructs missing modalities using both task-agnostic and task-specific representations, and a modality-aware replay mechanism that prioritizes informative samples based on modality distortion and distribution drift. Experiments on three representative multi-modal AQA datasets (RG, Fis-V, and FS1000) show that BriMA consistently improves performance under different modality-missing conditions, achieving 6--8% higher correlation and 12--15% lower error on average. These results demonstrate a step toward robust multi-modal AQA systems under real-world deployment constraints.

Predicting survival outcomes for non-small cell lung cancer (NSCLC) patients is challenging due to the different individual prognostic features. This task can benefit from the integration of whole-slide images, bulk transcriptomics, and DNA methylation, which offer complementary views of the patient's condition at diagnosis. However, real-world clinical datasets are often incomplete, with entire modalities missing for a significant fraction of patients. State-of-the-art models rely on available data to create patient-level representations or use generative models to infer missing modalities, but they lack robustness in cases of severe missingness. We propose a Multimodal Contrastive Variational AutoEncoder (MCVAE) to address this issue: modality-specific variational encoders capture the uncertainty in each data source, and a fusion bottleneck with learned gating mechanisms is introduced to normalize the contributions from present modalities. We propose a multi-task objective that combines survival loss and reconstruction loss to regularize patient representations, along with a cross-modal contrastive loss that enforces cross-modal alignment in the latent space. During training, we apply stochastic modality masking to improve the robustness to arbitrary missingness patterns. Extensive evaluations on the TCGA-LUAD (n=475) and TCGA-LUSC (n=446) datasets demonstrate the efficacy of our approach in predicting disease-specific survival (DSS) and its robustness to severe missingness scenarios compared to two state-of-the-art models. Finally, we bring some clarifications on multimodal integration by testing our model on all subsets of modalities, finding that integration is not always beneficial to the task.

Despite the recent success of Multimodal Large Language Models (MLLMs), existing approaches predominantly assume the availability of multiple modalities during training and inference. In practice, multimodal data is often incomplete because modalities may be missing, collected asynchronously, or available only for a subset of examples. In this work, we propose PRIMO, a supervised latent-variable imputation model that quantifies the predictive impact of any missing modality within the multimodal learning setting. PRIMO enables the use of all available training examples, whether modalities are complete or partial. Specifically, it models the missing modality through a latent variable that captures its relationship with the observed modality in the context of prediction. During inference, we draw many samples from the learned distribution over the missing modality to both obtain the marginal predictive distribution (for the purpose of prediction) and analyze the impact of the missing modalities on the prediction for each instance. We evaluate PRIMO on a synthetic XOR dataset, Audio-Vision MNIST, and MIMIC-III for mortality and ICD-9 prediction. Across all datasets, PRIMO obtains performance comparable to unimodal baselines when a modality is fully missing and to multimodal baselines when all modalities are available. PRIMO quantifies the predictive impact of a modality at the instance level using a variance-based metric computed from predictions across latent completions. We visually demonstrate how varying completions of the missing modality result in a set of plausible labels.

Multimodal systems are vulnerable to partial or complete loss of input channels at deployment, which undermines reliability in real-world settings. This paper presents ModalImmune, a training framework that enforces modality immunity by intentionally and controllably collapsing selected modality information during training so the model learns joint representations that are robust to destructive modality influence. The framework combines a spectrum-adaptive collapse regularizer, an information-gain guided controller for targeted interventions, curvature-aware gradient masking to stabilize destructive updates, and a certified Neumann-truncated hyper-gradient procedure for automatic meta-parameter adaptation. Empirical evaluation on standard multimodal benchmarks demonstrates that ModalImmune improves resilience to modality removal and corruption while retaining convergence stability and reconstruction capacity.

As multimodal systems increasingly process sensitive personal data, the ability to selectively revoke specific data modalities has become a critical requirement for privacy compliance and user autonomy. We present Missing-by-Design (MBD), a unified framework for revocable multimodal sentiment analysis that combines structured representation learning with a certifiable parameter-modification pipeline. Revocability is critical in privacy-sensitive applications where users or regulators may request removal of modality-specific information. MBD learns property-aware embeddings and employs generator-based reconstruction to recover missing channels while preserving task-relevant signals. For deletion requests, the framework applies saliency-driven candidate selection and a calibrated Gaussian update to produce a machine-verifiable Modality Deletion Certificate. Experiments on benchmark datasets show that MBD achieves strong predictive performance under incomplete inputs and delivers a practical privacy-utility trade-off, positioning surgical unlearning as an efficient alternative to full retraining.

Current Multimodal Affective Computing (MAC) systems heavily rely on the completeness of multiple modalities to accurately understand human's affective state. However, in real-world scenarios, the availability of modality data is often dynamic and uncertain, leading to substantial performance fluctuations due to the distribution shifts and semantic deficiencies of the incomplete multimodal inputs. Known as the missing modality issue, this challenge poses a critical barrier to the robustness and practical deployment of MAC models. To systematically quantify this issue, we introduce MissMAC-Bench, a comprehensive benchmark designed to establish fair and unified evaluation standards from the perspective of cross-modal synergy. Two guiding principles are proposed, including no missing prior during training, and one single model capable of handling both complete and incomplete modality scenarios, thereby ensuring better generalization. Moreover, to bridge the gap between academic research and real-world applications, our benchmark integrates evaluation protocols with both fixed and random missing patterns at the dataset and instance levels. Extensive experiments conducted on 3 widely-used language models across 4 datasets validate the effectiveness of diverse MAC approaches in tackling the missing modality issue. Our benchmark provides a solid foundation for advancing robust MAC and promotes the development of multimedia data mining. Our code is released in https://github.com/RH-Lin/MissMAC-Bench.

Federated Learning with LoRA fine-tuning offers an efficient and privacy-aware solution for institutions to collaboratively leverage their large datasets to train VLLMs. However, participating institutions often possess heterogeneous computational resources, resulting in imbalanced LoRA ranks, which pose a major challenge for effective collaboration. In addition, real-world applications in domains such as healthcare and transportation frequently suffer from missing modalities due to user mistakes or device failures, which significantly degrade global model performance in federated settings. To the best of our knowledge, no prior work has addressed these two challenges simultaneously in federated VLLMs. To tackle these issues, we propose FediLoRA, a lightweight federated LoRA aggregation framework that effectively mitigates the impact of missing modalities in heterogeneous environment. FediLoRA is explicitly motivated by the observation that simple averaging and structured editing can jointly benefit both global and personalized models. Our approach achieves strong performance across multiple general-domain and medical-domain benchmark datasets. Additional experiments on healthcare data further demonstrate that FediLoRA is well-suited for practical, real-world deployment scenarios. Our code is released at https://github.com/gotobcn8/FediLoRA.

Multimodal emotion and intent recognition is essential for automated human-computer interaction, It aims to analyze users' speech, text, and visual information to predict their emotions or intent. One of the significant challenges is that missing modalities due to sensor malfunctions or incomplete data. Traditional methods that attempt to reconstruct missing information often suffer from over-coupling and imprecise generation processes, leading to suboptimal outcomes. To address these issues, we introduce an Attention-based Diffusion model for Missing Modalities feature Completion (ADMC). Our framework independently trains feature extraction networks for each modality, preserving their unique characteristics and avoiding over-coupling. The Attention-based Diffusion Network (ADN) generates missing modality features that closely align with authentic multimodal distribution, enhancing performance across all missing-modality scenarios. Moreover, ADN's cross-modal generation offers improved recognition even in full-modality contexts. Our approach achieves state-of-the-art results on the IEMOCAP and MIntRec benchmarks, demonstrating its effectiveness in both missing and complete modality scenarios.

With the increasing multimodal knowledge privatization requirements, multimodal knowledge graphs in different institutes are usually decentralized, lacking of effective collaboration system with both stronger reasoning ability and transmission safety guarantees. In this paper, we propose the Federated Multimodal Knowledge Graph Completion (FedMKGC) task, aiming at training over federated MKGs for better predicting the missing links in clients without sharing sensitive knowledge. We propose a framework named MMFeD3-HidE for addressing multimodal uncertain unavailability and multimodal client heterogeneity challenges of FedMKGC. (1) Inside the clients, our proposed Hyper-modal Imputation Diffusion Embedding model (HidE) recovers the complete multimodal distributions from incomplete entity embeddings constrained by available modalities. (2) Among clients, our proposed Multimodal FeDerated Dual Distillation (MMFeD3) transfers knowledge mutually between clients and the server with logit and feature distillation to improve both global convergence and semantic consistency. We propose a FedMKGC benchmark for a comprehensive evaluation, consisting of a general FedMKGC backbone named MMFedE, datasets with heterogeneous multimodal information, and three groups of constructed baselines. Experiments conducted on our benchmark validate the effectiveness, semantic consistency, and convergence robustness of MMFeD3-HidE.

Building reliable speech systems often requires combining multiple modalities, like audio and visual cues. While such multimodal solutions frequently lead to improvements in performance and may even be critical in certain cases, they come with several constraints such as increased sensory requirements, computational cost, and modality synchronization, to mention a few. These challenges constrain the direct uses of these multimodal solutions in real-world applications. In this work, we develop approaches where the learning happens with all available modalities but the deployment or inference is done with just one or reduced modalities. To do so, we propose a Multimodal Training and Unimodal Deployment (MUTUD) framework which includes a Temporally Aligned Modality feature Estimation (TAME) module that can estimate information from missing modality using modalities present during inference. This innovative approach facilitates the integration of information across different modalities, enhancing the overall inference process by leveraging the strengths of each modality to compensate for the absence of certain modalities during inference. We apply MUTUD to various audiovisual speech tasks and show that it can reduce the performance gap between the multimodal and corresponding unimodal models to a considerable extent. MUTUD can achieve this while reducing the model size and compute compared to multimodal models, in some cases by almost 80%.