Synthetic-To-Real Domain Gap

Myotubes are multinucleated muscle fibers serving as key model systems for studying muscle physiology, disease mechanisms, and drug responses. Mechanistic studies and drug screening thereby rely on quantitative morphological readouts such as diameter, length, and branching degree, which in turn require precise three-dimensional instance segmentation. Yet established pretrained biomedical segmentation models fail to generalize to this domain due to the absence of large annotated myotube datasets. We introduce a geometry-driven synthesis pipeline that models individual myotubes via polynomial centerlines, locally varying radii, branching structures, and ellipsoidal end caps derived from real microscopy observations. Synthetic volumes are rendered with realistic noise, optical artifacts, and CycleGAN-based Domain Adaptation (DA). A compact 3D U-Net with self-supervised encoder pretraining, trained exclusively on synthetic data, achieves a mean IPQ of 0.22 on real data, significantly outperforming three established zero-shot segmentation models, demonstrating that biophysics-driven synthesis enables effective instance segmentation in annotation-scarce biomedical domains.

Training multimodal large language models (MLLMs) for video understanding requires large-scale annotated data spanning diverse tasks such as object counting, question answering, and segmentation. However, collecting and annotating multimodal video data in real-world is costly, slow, and inherently limited in diversity and coverage. To address this challenge, we propose~\textbf{SynMulti} dataset, along with a unified synthetic data generation pipeline capable of automatically producing unlimited multimodal video data with rich and diverse supervision. Our framework supports multiple task formats within a single pipeline, enabling scalable and consistent data creation across tasks. To further enhance reasoning ability, we introduce a VQA-based fine-tuning strategy that trains models to answer structured questions about visual content rather than relying solely on captions or simple instructions. This formulation encourages deeper visual grounding and reasoning. We evaluate our approach in three challenging tasks: video object counting, video-based visual question answering, and video object segmentation. Experimental results demonstrate that models trained predominantly on synthetic data generalize effectively to real-world datasets, often outperforming traditionally trained counterparts. Our findings highlight the potential of unified synthetic data pipelines as a scalable alternative to expensive real-world annotation for multimodal video understanding.

Despite remarkable advances in image-driven stereo matching over the past decade, Synthetic-to-Realistic ZeroShot (Syn-to-Real) generalization remains an open challenge. This suboptimal generalization performance mainly stems from cross-domain shifts and ill-posed ambiguities inherent in image textures, particularly in occluded, textureless, repetitive, and non-Lambertian (specular/transparent) regions. To improve Synto-Real generalization, we propose GREATEN, a framework that incorporates surface normals as domain-invariant, object-intrinsic, and discriminative geometric cues to compensate for the limitations of image textures. The proposed framework consists of three key components. First, a Gated Contextual-Geometric Fusion (GCGF) module adaptively suppresses unreliable contextual cues in image features and fuses the filtered image features with normal-driven geometric features to construct domain-invariant and discriminative contextual-geometric representations. Second, a Specular-Transparent Augmentation (STA) strategy improves the robustness of GCGF against misleading visual cues in non-Lambertian regions. Third, sparse attention designs preserve the fine-grained global feature extraction capability of GREATStereo for handling occlusion and texture-related ambiguities while substantially reducing computational overhead, including Sparse Spatial (SSA), Sparse Dual-Matching (SDMA), and Simple Volume (SVA) attentions. Trained exclusively on synthetic data such as SceneFlow, GREATEN-IGEV achieves outstanding Syn-to-Real performance. Specifically, it reduces errors by 30% on ETH3D, 8.5% on the non-Lambertian Booster, and 14.1% on KITTI-2015, compared to FoundationStereo, Monster-Stereo, and DEFOM-Stereo, respectively. In addition, GREATEN-IGEV runs 19.2% faster than GREAT-IGEV and supports high-resolution (3K) inference on Middlebury with disparity ranges up to 768.

Deep learning models deployed in safety critical applications like autonomous driving use simulations to test their robustness against adversarial attacks in realistic conditions. However, these simulations are non-differentiable, forcing researchers to create attacks that do not integrate simulation environmental factors, reducing attack success. To address this limitation, we introduce UNDREAM, the first software framework that bridges the gap between photorealistic simulators and differentiable renderers to enable end-to-end optimization of adversarial perturbations on any 3D objects. UNDREAM enables manipulation of the environment by offering complete control over weather, lighting, backgrounds, camera angles, trajectories, and realistic human and object movements, thereby allowing the creation of diverse scenes. We showcase a wide array of distinct physically plausible adversarial objects that UNDREAM enables researchers to swiftly explore in different configurable environments. This combination of photorealistic simulation and differentiable optimization opens new avenues for advancing research of physical adversarial attacks.

Synthetic Aperture Radar (SAR) imagery provides robust environmental and temporal coverage (e.g., during clouds, seasons, day-night cycles), yet its noise and unique structural patterns pose interpretation challenges, especially for non-experts. SAR-to-EO (Electro-Optical) image translation (SET) has emerged to make SAR images more perceptually interpretable. However, traditional approaches trained from scratch on limited SAR-EO datasets are prone to overfitting. To address these challenges, we introduce Confidence Diffusion for SAR-to-EO Translation, called C-DiffSET, a framework leveraging pretrained Latent Diffusion Model (LDM) extensively trained on natural images, thus enabling effective adaptation to the EO domain. Remarkably, we find that the pretrained VAE encoder aligns SAR and EO images in the same latent space, even with varying noise levels in SAR inputs. To further improve pixel-wise fidelity for SET, we propose a confidence-guided diffusion (C-Diff) loss that mitigates artifacts from temporal discrepancies, such as appearing or disappearing objects, thereby enhancing structural accuracy. C-DiffSET achieves state-of-the-art (SOTA) results on multiple datasets, significantly outperforming the very recent image-to-image translation methods and SET methods with large margins.