Weakly Supervised Image Segmentation

Multi-tumor segmentation is important for early cancer detection and allows radiologists to visualize, verify, and understand AI predictions. However, tumor segmentation masks are expensive, time-consuming, and unavailable for many tumor types in public data. Instead, hospitals have vast, readily available data that can guide segmentation: radiology reports, longitudinal images, and multi-phase images. We use this readily available data to substitute for tumor masks in training AI for tumor segmentation. To this end, we propose a new architecture, RT-Super. It has a teacher network, which analyzes the patient's longitudinal images and reports to create high-quality tumor masks. These masks train a student network, which sees a single image and no report. At inference, when longitudinal images and reports are unavailable, we use the student. RT-Super uses a new CNN-Transformer architecture and novel Consistency Losses that exploit tumor location consistency across longitudinal images. We train RT-Super to segment esophagus, uterus and spleen tumors, which have few or no public masks. Even without training masks, RT-Super can segment these tumors and surpass public AI models. Overall, we demonstrate that learning from longitudinal images, multi-phase images, and reports can overcome mask scarcity and advance multi-cancer detection and segmentation. Code: https://github.com/MrGiovanni/RT-Super

Segmentation of complex structures in X-ray tomographic data is a fundamental task in biomedical research, but it often requires large amounts of precisely annotated data, making fully supervised approaches costly and difficult to scale. In this study, weakly supervised deep learning is investigated as a strategy to reduce annotation effort while maintaining accurate segmentation. A two-dimensional convolutional neural network based on the nnU-Net framework was adapted to a weak supervision setting using sparse dot-based annotations, complemented by a limited number of fully segmented images. The approach was evaluated on high-resolution microCT slices of rat kidneys, targeting the segmentation of renal glomeruli, which are small, low-contrast anatomical structures. Results indicate that weak supervision provides a meaningful learning signal, enabling reliable localization of glomeruli even in the absence of dense labels. Incorporating a small set of high-quality annotations substantially improves segmentation performance, approaching that of a fully supervised model. These findings highlight the potential of weakly supervised learning as an annotation-efficient strategy for the analysis of complex structures in X-ray tomographic data, and suggest that alternative loss formulations tailored to sparse annotations may further enhance performance.

In semiconductor manufacturing, defect analysis is essential, but manual inspection cannot scale. However, existing automated inspection methods remain insufficient for root-cause analysis and process optimization. To this end, we present SePArate, a weakly supervised wafer defect segmentation method. SePArate enables pixel-level separation of patterns by leveraging only image-level annotations. It consists of a three-phase training: encoder pretraining, knowledge transfer to learn spatial cues, and training on synthetic mixed-defect data for accurate segmentation. Experiments demonstrate that SePArate outperforms the baselines.

Medical image segmentation heavily depends on labor-intensive and time-consuming pixel-level annotations. Eye tracking offers a cost-effective solution that can be naturally integrated into clinical workflows. Recorded by eye trackers, gaze conveys the spatial regions of clinicians' attention through fixations and the temporal context of clinicians' progressive visual perception from trajectories. Nevertheless, effective modeling of temporal trajectories remains challenging, and noise in gaze caused by exploratory fixations greatly limits segmentation performance. To overcome these limitations, we propose the Trajectory-guided Uncertainty-aware Network (TrailNet), which exploits gaze-supervised medical image segmentation from spatial semantics modeling to temporal context by jointly leveraging fixations and trajectories. Specifically, the proposed trajectory-guided spatio-temporal encoder models temporal context and establishes complementary interactions with image spatial semantics to strengthen target perception. Furthermore, the multi-scale uncertainty decoder leverages category mutual-exclusivity constraints to produce deterministic predictions and mitigate supervision uncertainty induced by noise. To enable gaze-free inference, we further introduce a cycle distillation strategy that transfers feature-level knowledge via teacher-student networks. Experimental results on two public datasets demonstrate that TrailNet outperforms state-of-the-art methods, achieving Dice scores of 81.25% and 81.85%, respectively.

We introduce a method for training a text-conditioned segmentation model for CT scans, which combines voxel-level supervision with coarse but scalable slice-level supervision from reports. We extract, from a large database of scan-report pairs, descriptions of findings with indices of slices where those findings occur. We then finetune a general-purpose 2D image segmentation model, SAM3, with standard segmentation losses from strongly labeled data and with a slice-level classification loss from the extracted weak supervision. Our results on the ReXGroundingCT dataset illustrate that this strategy improves the segmentation dice score: from an 8% relative gain when there are 1000 fully labeled volumes to 22% when there are 250 fully labeled volumes.

Scribble annotations offer an efficient alternative to costly pixel-wise labeling for medical image segmentation, yet in real clinical scenarios, scribble-annotated samples are often still limited, imposing the dual challenges of sparse supervision and annotated sample scarcity. These compounded constraints severely deprive models of the structural evidence needed for complete region recovery and precise boundary delineation. To break this bottleneck, we propose a bi-level collaborative learning framework for few-shot scribble-supervised medical image segmentation. Specifically, an upper-level learnable superpixel model is introduced to provide region-structural priors for lower-level segmentation, while superpixel-based region-wise pseudo-label propagation and a spatial-prior-guided filtering strategy are performed to generate reliable dense pseudo-labels for segmentation learning. Meanwhile, the anatomical semantics learned by the lower-level segmentation model under the guidance of the current superpixels are fed back to the upper level, further driving it to learn region-structural representations better aligned with the segmentation task. Through bidirectional interaction and collaborative learning between the upper and lower levels, the proposed framework significantly outperforms existing state-of-the-art scribble-supervised methods on the ACDC and Prostate datasets under the few-shot scribble-supervised setting.

Few-shot segmentation (FSS) commonly assumes clean pixel-level support masks, yet practical support supervision often uses boxes, scribbles, coarse masks, or pseudo-masks. These weak annotations may include texture-similar distractors and background context alongside the target, contaminating class prototypes or visual prompts before query prediction. We introduce SADe, a predictor-agnostic support decontamination layer that estimates the reliability of selected support patches without query information. Central to SADe is sparse autoencoder (SAE) atom evidence: dense similarity may respond to both target and texture-similar context, whereas contrasting atom activations inside and outside the weak-support region provides factor-level reliability cues. A lightweight router combines atom evidence with dense similarity and episode statistics to predict patch reliability and generate a cleaned support mask. Trained once on synthetic weak-support episodes from FSS-1000, the router is frozen for all target evaluations. The resulting mask supports standalone prediction or can be supplied to heterogeneous FSS models through native support interfaces without altering query-side inference. Under a matched weak-support protocol, SADe achieves the highest query mIoU in six of nine standalone prompt-shot combinations. With the same ProMi query head, it is within 0.03 mIoU of SAM3-derived masks under tight boxes and surpasses them by 11.17 and 19.49 points under box-r2 and box-r4, respectively. As a plug-in, SADe improves over raw support in 70 of 72 matched box-family comparisons across four frozen downstream models and two datasets. On point and scribble prompts, its average performance remains close to the corresponding raw-support baseline. Ablations and atom-removal controls show that atom evidence contributes reliability information beyond dense similarity.

Weakly supervised segmentation relies heavily on class activation maps (CAMs) to initially localize target regions. However, CAMs are often noisy and prone to catastrophic failures. Existing remedies typically introduce additional training stages or prototype learning, increasing computational cost and reducing robustness. In this paper, we propose a training-free prototype-free framework that rectifies unreliable CAMs by exploiting temporal and structural coherence in volumetric data as a free lunch. Our approach is built on two key components. First, we introduce Variance-Reduced Activation Aggregation (VRAA) which suppresses noise and amplify coherent semantic signals. We provide a theoretical justification by modeling CAMs as high-dimensional random vectors and show that aggregation yields provable variance reduction. Second, we design a Bidirectional Extremity Rectification (BER) mechanism that detects and rectifies implausible activations through bidirectional extremity checks, effectively mitigating extreme-value failures without learning additional parameters. Our method is model-agnostic and can be seamlessly integrated with existing pipelines. Extensive experiments on multiple public benchmarks demonstrate substantial improvements over state-of-the-art weakly supervised methods, achieving up to 20% Dice and 40% mIoU gains while reducing inference time by more than 5 times. These results indicate that leveraging coherence as an implicit inductive bias yields a principled and efficient approach to stabilizing weakly supervised volumetric segmentation. Our code will be available.

We propose a unified variational framework for image segmentation under sparse pixel-level supervision. Our method is based on a simplex-constrained Potts model with a smooth perimeter regularizer, yielding a convex, smooth energy functional that can be used as a training loss in weakly supervised deep learning paradigms or optimized efficiently using iterative methods. Sparse labels are incorporated into the data fidelity term by constructing a fuzzy membership function via a function extension problem in a Reproducing Kernel Hilbert Space (RKHS), which can effectively capture inhomogeneous intensity statistics. The derived discrete loss for training standard networks demonstrates robustness and consistent improvements over non-training and partial cross-entropy (PCE) baselines in experiments, achieving comparable performance without requiring ground-truth segmentation images.

Weakly-supervised RGB-D Salient Object Detection (SOD) is explored to reduce the heavy burden of pixel-level annotations. But scribble annotations lack the structure and details of objects, resulting in inaccurate saliency maps. In this paper, we propose a novel scribble-supervised RGB-D SOD method, consisting of a Segment Anything Model (SAM)-driven pseudo annotation generation method (\emph{SAM-PAG}) and a state space interaction-based conditional diffusion model (\emph{$S^2$Diff}). Specifically, SAM-PAG is tailored to address the issue of sparse supervision information. In SAM-PAG, we adopt the advanced SAM to expand sparse scribbles to dense pixel-level pseudo annotations through the dual-branch structure and the consistency of segmentation masks. In $S^2$Diff, we adopt the diffusion model to iteratively refine the noisy saliency maps with the guidance of conditional information, generating accurate saliency maps. Naturally, the core of our $S^2$Diff lies in the acquisition of conditional features and the denoising of saliency maps. For the former, we employ a cross-modal conditional generation module to interweave cross-modal features through frequency integration and implicit-explicit state space interaction, effectively achieving global conditional features. For the latter, we employ a context injection module to mitigate noise interference and to enhance object information with the conditional context. With the close cooperation of SAM-PAG and $S^2$Diff, our method outperforms relevant scribble-supervised methods and achieves competitive performance compared to fully-supervised methods on seven datasets. The code and results of our method are available at https://github.com/Switch457/WeakS2Diff_SOD.

Whole-slide images (WSIs) provide rich tissue-level and cellular-level information, but storing and transmitting high-magnification pathology data is resource-intensive. Moreover, annotating WSIs at the pixel level is labor-intensive and time-consuming. Therefore, it is important to investigate whether low-magnification pathology images with limited annotations (i.e., image-level instead of pixel-level labels) can achieve performance comparable to high-magnification images. This paper presents a systematic benchmark study on weakly supervised histopathological image segmentation under different low-resolution storage settings. Starting from high-resolution image patches, we simulate lower-magnification inputs and reconstruct them to the original size using interpolation and deep learning-based reconstruction methods before applying the weakly-supervised segmentation pipeline. This framework enables a quantitative evaluation of how weakly supervised methods respond to different levels of resolution degradation. Experimental results show that reconstruction quality metrics alone are insufficient to predict downstream segmentation performance. In particular, the study identifies a critical degradation point where the localization of small-scale structures declines significantly. These findings provide practical guidance for designing efficient digital pathology storage systems while maintaining reliable automated analysis. Code is available at https://github.com/Dung-Dx/LowMagWSS

Pixel-level annotation remains a major bottleneck in medical image segmentation, making weak supervision an attractive yet under-constrained alternative. We propose OBBSeg, an intermediate supervision paradigm guided by Oriented Bounding Boxes (OBBs) that bridges the gap between full and weak supervision. By jointly encoding spatial extent and orientation, OBBs provide compact geometric supervision that better aligns with elongated or anisotropic lesions, reducing the ambiguity of coarse box annotations. To mitigate the inherent rectangular bias of OBBs, we introduce a Mask-to-OBB loss, a differentiable formulation that enforces geometric consistency between predicted masks and OBB regions. Furthermore, we incorporate prompt-driven semantic guidance through two complementary modules-PAFE and DBFE-which enhance foreground representation and suppress background interference. Extensive experiments on 13 datasets across 5 imaging modalities show that OBBSeg not only outperforms existing weakly supervised methods but also achieves performance comparable to fully supervised approaches, demonstrating its potential for efficient and scalable medical image segmentation. The code is available at https://github.com/StarLxc3/OBBSeg.

Histopathological tissue segmentation is essential for computer-aided diagnosis, yet weakly supervised methods often suffer from noisy pseudo-labels generated by Class Activation Mapping (CAM). Existing CAM approaches tend to focus on staining-driven appearance cues rather than true causal tissue morphology, resulting in spurious localization and poor structural consistency. To address this issue, we propose C$^2$RM-Seg, a two-stage framework that integrates causal pseudo-label refinement with structure-aware semantic enhancement. For classification, we introduce a Causal Counterfactual Reasoning Module (C$^2$RM) that decomposes features into latent factors and performs counterfactual intervention via a learned causal structure matrix, suppressing confounding context and producing morphology-aligned CAMs. For segmentation, we design a Dual-Path Structural-Semantic Architecture that combines fine-grained structural features from ResNeSt with global semantic priors from a frozen DINOV3 foundation model. A cross-path gating mechanism adaptively regulates semantic injection using local structural cues to preserve boundary fidelity. To further mitigate residual pseudo-label noise, we propose an Uncertainty-Gated Margin (UGM) loss, which dynamically balances margin enforcement and confidence learning based on prediction uncertainty. Extensive experiments on two public histopathological tissue datasets show that C$^2$RM-Seg achieves state-of-the-art performance.

Existing weakly supervised semantic segmentation (WSSS) methods in computational pathology rely on a multi-stage paradigm: class activation map (CAM) generation, offline pseudo-mask refinement, and fully supervised retraining. While established, this decoupled approach presents fundamental limitations. The multi-stage process not only incurs high computational training costs but also suffers from error propagation: local texture biases in shallow CNN layers generate false-positive artifacts that subsequent refinement steps often fail to correct. To address these persistent challenges through a simple yet highly effective approach, we propose the Single-Stage Hierarchical Rectification (SSHR) framework. Rather than passively refining CAMs post-hoc, our method proactively purifies intermediate feature representations during the forward pass. We introduce a Hierarchical Feature Rectification Module (HFRM) that utilizes deep global semantic context to filter out local anomalies in shallow layers. This mechanism generates high-fidelity activation maps directly within a single training loop. Experiments on the LUAD-HistoSeg and BCSS datasets demonstrate that SSHR outperforms state-of-the-art multi-stage methods. Furthermore, SSHR reduces training duration by 2 to 5 times. This efficiency minimizes computational overhead and accelerates clinical translation for large-scale histopathology workflows. The code is available at: https://github.com/trongduc-nguyen/SSHR

Open-vocabulary scene sketch semantic segmentation aims to assign dense semantic labels to sparse line drawings based on flexible category vocabularies specified at inference time, without relying on pixel-level annotations during training. Unlike natural images, sketches lack texture and color cues, making semantic understanding heavily dependent on stroke layout and spatial configuration, a challenge that renders single-layer vision-language features inherently unstable. Our key observation is that attention maps from different Vision Transformer layers encode complementary spatial cues: shallow layers capture global structural layouts, while deeper layers focus on local stroke intersections and object parts. This suggests that cross-layer aggregation provides a more robust structural prior than any individual layer alone. Leveraging this insight, we propose a structure-aware framework built upon \textbf{L}ayer-wise \textbf{A}ccumulated \textbf{S}tructural \textbf{A}ttention (\textbf{LASA}), which aggregates multi-layer attention to guide hierarchical semantic alignment under weak supervision and refine predictions during inference. Experiments on FS-COCO, SFSD, and FrISS show that LASA improves mIoU by $+3.43$, $+8.01$, and $+15.74$ over the prior weakly supervised baselines, demonstrating consistent gains in both segmentation accuracy and spatial coherence. Our source code will be made publicly available.

Every new clinical imaging device creates a domain shift where dense gland masks are expensive yet cheap clinical signals -- eyelid outlines, Pult grades, morphometric ratios -- are routinely recorded. We present TopoPult-SSL, a two-stage framework for cross-device meibomian gland segmentation. Stage 1 adapts a source-trained model without target gland masks in the training loss, using four weak-prior anchors driven by target eyelid masks and clinical metadata only. Stage 2, when target gland masks are available, distils complementary Stage-1 teachers into a single compact student via supervised self-distillation. We develop and validate the technique on the public MGD-1k to CAMG research benchmark (1,000 to 100 images, different device), where the distilled model achieves Dice 0.716+/-0.006 (best 0.726), surpassing UA-MT (0.710) and the ensemble teacher (0.720) -- with a single pass. The gland-mask-free Stage-1 variant reaches Precision 0.694 vs. 0.30-0.34 for SAM/MedSAM (p<0.001), enabling deployment without dense gland contouring. Code and reproducibility scripts are released.

Weakly Incremental Learning for Semantic Segmentation (WILSS) suffers from the continuous introduction of noisy supervision, which progressively corrupts class-level representations, leading to severe feature drift and semantic corruption, thereby causing newly learned classes to overwrite old ones. To address these issues, we propose a drift-resilient WILSS approach, named SASA, designed to stabilize semantic learning via Semantic Anchors and Spatial Arbitration. Specifically, at the representation level, we introduce semantic anchors of learnable tokens as rigid class-level references to preserve long-term semantic identity. Complementary to this, an elastic residual adaptation facilitates controlled, instance-specific refinement, ensuring a stable yet flexible learning trajectory. At the supervision level, we develop a Spatial Label Arbitration mechanism that performs geometry-aware decisions to directly filter unreliable signals and enforce a strict "one object, one class" constraint. By synergistically stabilizing representations and improving supervision reliability, SASA effectively mitigates feature drift under weak supervision. Extensive experiments on standard benchmarks demonstrate that our approach consistently outperforms existing state-of-the-art methods, particularly in challenging multi-step incremental settings. The code is available at https://github.com/ZhonggaiWang/SASA.

Instance-level quantification of kidney functional units is essential for morphometric analysis, yet most publicly available pathology datasets provide only semantic segmentation annotations, where adjacent structures of the same class are merged into single regions. This prevents reliable instance-level analysis and limits downstream quantitative studies. Existing heuristic post-processing methods often yield suboptimal instance separation, particularly in crowded and adherent regions, while deep learning-based instance segmentation approaches typically require intensive instance-level annotations that are costly and labor-intensive to obtain. We propose MORI-Seg, a deep learning framework that enables instance segmentation without requiring instance-level annotations. Instead of heuristic splitting or instance supervision, MORI-Seg learns morphology-aware geometric representations directly from semantic masks by jointly modeling object-centric distance fields and boundary-band representations to encode interior structure and contact interfaces. A class-conditioned feature disentanglement module further promotes intra-instance coherence and inter-instance separation. Under semantic-only supervision, MORI-Seg decomposes connected semantic regions into distinct instance masks in an end-to-end manner. Experiments demonstrate improved instance separation accuracy and more reliable morphometric quantification compared with classical post-processing pipelines and representative semantic-to-instance learning approaches. The official implementation is publicly available at https://github.com/ddrrnn123/MORI-Seg.

Camouflaged object detection (COD) from a single image is a challenging task due to the high similarity between objects and their surroundings. Existing fully supervised methods require labor-intensive pixel-level annotations, making weakly supervised methods a viable compromise that balances accuracy and annotation efficiency. However, weakly supervised methods often experience performance degradation due to the use of coarse annotations. In this paper, we introduce a new weakly supervised approach for camouflaged object detection to overcome these limitations. Specifically, we propose a novel network, MGNet, which tackles edge ambiguity and missed detections by utilizing initial masks generated by our custom-designed Cascaded Mask Decoder (CMD) to guide the segmentation process and enhance edge predictions. We introduce a Context Enhancement Module(CEM) to reduce the missing detection, and a Mask-guided Feature Aggregation Module (MFAM) for effective feature aggregation. For the weak supervision challenge, we propose BoxSAM, which leverages the Segment Anything Model (SAM) with bounding-box prompts to generate pseudo-labels. By employing a redundant processing strategy, high quality pixel-level pseudo-labels are provided for training MGNet. Extensive experiments demonstrate that our method delivers competitive performance against current state-of-the-art methods.

Accurate cell segmentation in pathology images typically requires dense pixel-wise annotations, which are costly and time-consuming to obtain. This challenge is especially important for emerging biological imaging modalities and multiplexed datasets with variable channel configurations, where expert-labeled data are scarce. In this work, we introduce ImPartial, a deep learning framework designed to achieve state-of-the-art segmentation performance in low-annotation regimes using sparse scribbles and limited supervision. ImPartial augments the segmentation objective via self-supervised multi-channel quantized imputation. This approach leverages the observation that perfect pixel-wise reconstruction or denoising of the image is not needed for accurate segmentation, and thus, introduces a self-supervised classification objective that better aligns with the overall segmentation goal. We demonstrate that ImPartial achieves performance at par with fully supervised models while requiring substantially fewer annotations. Extensive experiments on benchmark multiplexed cellular imaging and single-plex clinical brightfield immunohistochemistry datasets show consistent improvements over strong baselines with only partial annotations. All benchmark datasets and code are available via our Github: https://github.com/nadeemlab/ImPartial.

Weakly supervised semantic segmentation (WSSS) trains dense pixel-level segmentation models from partial or coarse annotations such as bounding boxes, scribbles, or image-level tags. While recent work leverages foundation models such as the Segment Anything Model (SAM) to generate pseudo-labels, these approaches typically depend on heuristic prompt choices and offer limited ways to incorporate prior knowledge or heterogeneous labels. We address this gap by taking a neurosymbolic perspective: integrating differentiable fuzzy logic with deep segmentation models. Weak annotations and domain-specific priors are unified as continuous logical constraints that fine-tune SAM under weak supervision. The refined foundation model then produces improved pseudo-labels, from which we train a second-stage prompt-free segmentation model. Experiments on Pascal VOC 2012 and the REFUGE2 optic disc/cup segmentation dataset show that our logic-guided fine-tuning yields higher-quality pseudo-labels, leading to state-of-the-art segmentation accuracy that often exceeds densely supervised baselines.

INTRODUCTION | Fully supervised 3D segmentation of high-resolution ex vivo MRI is limited by the prohibitive cost of volumetric annotation, forcing reliance on sparse 2D slices. Weakly supervised Sparse-to-Dense frameworks bridge this gap, but guidelines remain ambiguous regarding human-centric visual enhancements and transferring optimization strategies across dimensions. We analyze divergent regularization needs for multi-class segmentation of high-resolution ex vivo spinal cord MRI. METHODS | We used 9.4T MRI of multiple sclerosis spinal cords (>104,000 slices) with sparse annotations (428 slices). A 2D Teacher trained on sparse slices generated dense pseudo-labels to train a 3D Student. We systematically evaluated the impact of human-centric preprocessing, spatial augmentation, and soft-label regularization on both architectures. RESULTS | We identified a critical divergence in training dynamics. The 2D Teacher required strong spatial augmentation and soft-labeling to overcome data scarcity, improving White Matter Lesion Dice scores by >11 points. However, propagating these techniques to the 3D Student degraded its performance. Furthermore, human-centric preprocessing (e.g., CLAHE) disrupted global statistical cues, dropping Gray Matter Lesion Dice scores by ~25 points. DISCUSSION | Our study highlights a perception divergence (human-centric contrast enhancement harms machine models) and a regularization conflict across dimensions. 3D architectures trained on dense pseudo-labels exhibit fundamentally different optimization landscapes than 2D counterparts and require distinct, conservative regularization. Code and models: https://github.com/ivadomed/model_seg_sc-gm-lesion_human_ms_exvivo_t2star.

Curating fully annotated datasets for medical image segmentation is labour-intensive and expertise-demanding. To alleviate this problem, prior studies have explored scribble annotations for weakly supervised segmentation. Existing solutions mainly compute losses on annotated areas and generate pseudo labels by propagating annotations to adjacent regions. However, these methods often suffer from inaccurate and unrealistic segmentations due to insufficient supervision and incomplete shape information. In contrast, we first investigate the principle of good scribble annotations, which leads to efficient scribble forms via supervision maximization and randomness simulation. We further introduce regularization terms to encode the spatial relationship and the shape constraints, where the EM algorithm is utilized to estimate the mixture ratios of label classes. These ratios are critical in identifying the unlabeled pixels for each class and correcting erroneous predictions, thus the accurate estimation lays the foundation for the incorporation of spatial prior. Finally, we integrate the efficient scribble supervision with the prior into a framework, referred to as ZScribbleSeg, and apply it to multiple scenarios. Leveraging only scribble annotations, ZScribbleSeg achieves competitive performance on six segmentation tasks including ACDC, MSCMRseg, BTCV, MyoPS, Decathlon-BrainTumor and Decathlon-Prostate. Our code will be released via https://github.com/DLwbm123/ZScribbleSeg.

Weakly Supervised Semantic Segmentation (WSSS) with image-level labels typically leverages Class Activation Maps (CAMs) to achieve pixel-level predictions. Recently, Contrastive Language-Image Pre-training (CLIP) has been introduced to generate CAMs in WSSS. However, previous WSSS methods solely adopt CLIP's vision-language paired property for dense localization, neglecting its inherently limited dense knowledge across both visual and text modalities, which renders CAM generation suboptimal. In this work, we propose DiCLIP, a novel WSSS framework that leverages the generative diffusion model to enhance CLIP's dense knowledge across two modalities. Specifically, Visual Correlation Enhancement (VCE) and Text Semantic Augmentation (TSA) modules are proposed for dense prediction enhancement. To improve the spatial awareness of visual features, our VCE module utilizes diffusion's reliable spatial consistency to mitigate the over-smoothing issue in CLIP's attention. It designs the Attention Clustering Refinement (ACR) module to reliably extract diverse correlation maps from the diffusion model. The correlation maps act as a diversity bias for CLIP's self-attention, recursively pushing its visual features towards a more discriminative dense distribution. To augment the semantics of text embeddings, our TSA module argues that a single text modality is insufficient to encompass the variability of visual categories. Thus, we leverage diffusion's generative power to maintain a dynamic key-value cache model, shifting CAM generation from a patch-text matching mechanism to a novel visual knowledge retrieval paradigm. With these enhancements, DiCLIP not only outperforms state-of-the-art methods on PASCAL VOC and MS COCO but also significantly reduces training costs. Code is publicly available at https://github.com/zwyang6/DiCLIP.

Medical experts often manually segment images to obtain diagnostic statistics and discard the resulting annotations. We aim to train segmentation models to alleviate this burden, but constrained to the retained summary statistics (e.g., the area of the annotated region). Empirical results suggest that statistics alone are insufficient for this task, but adding weak information in the form of a few pixels within the area of interest significantly improves performance. We use a novel loss function that combines terms for image reconstruction quality, matching to summary statistics, and overlap between the predicted foreground and the weak supervisory signal. Experiments on standard image, ultrasound (breast cancer), and Computed Tomography (CT) scan (kidney tumors) data demonstrate the utility and potential of the approach.

In pathology, the spatial distribution and proportions of tissue types are key indicators of disease progression, and are more readily available than fine-grained annotations. However, these assessments are rarely mapped to pixel-wise segmentation. The task is fundamentally underdetermined, as many spatially distinct segmentations can satisfy the same global proportions in the absence of pixel-wise constraints. To address this, we introduce Variational Segmentation from Label Proportions (VSLP), a two-stage framework that infers dense segmentations from global label proportions, without any pixel-level annotations. This framework first leverages a pre-trained transformer model with test-time augmentation to produce a pixel-wise confidence estimate. In the second stage, these estimates are fused by solving a variational optimization problem that incorporates a Wasserstein data fidelity term alongside a learned regularizer. Unlike end-to-end networks, our variational method can visualize the fidelity-regularization energy, resulting in more interpretable segmentation. We validate our approach on two public datasets, achieving superior performance over existing weakly supervised and unsupervised methods. For one of these datasets, proportions have been estimated by an experienced pathologist to provide a realistic benchmark to the community. Furthermore, the method scales to an in-house dataset with noisy pathologist labels, severely outperforming state-of-the-art methods, thereby demonstrating practical applicability. The code and data will be made publicly available upon acceptance at https://github.com/xiaoliangpi/VSLP.

Weakly supervised semantic segmentation aims to achieve pixel-level predictions using image-level labels. Existing methods typically entangle semantic recognition and object localization, which often leads models to focus exclusively on sparse discriminative regions. Although foundation models show immense potential, many approaches still follow the tightly coupled optimization paradigm, struggling to effectively alleviate pseudo-label noise and often relying on time-consuming multi-stage retraining or unstable end-to-end joint optimization. To address the above challenges, we present ModuSeg, a training-free weakly supervised semantic segmentation framework centered on explicitly decoupling object discovery and semantic assignment. Specifically, we integrate a general mask proposer to extract geometric proposals with reliable boundaries, while leveraging semantic foundation models to construct an offline feature bank, transforming segmentation into a non-parametric feature retrieval process. Furthermore, we propose semantic boundary purification and soft-masked feature aggregation strategies to effectively mitigate boundary ambiguity and quantization errors, thereby extracting high-quality category prototypes. Extensive experiments demonstrate that the proposed decoupled architecture better preserves fine boundaries without parameter fine-tuning and achieves highly competitive performance on standard benchmark datasets. Code is available at https://github.com/Autumnair007/ModuSeg.

Meta-learning aims to uniformly sample homogeneous support-query pairs, characterized by the same categories and similar attributes, and extract useful inductive biases through identical network architectures. However, this identical network design results in over-semantic homogenization. To address this, we propose a novel homologous but heterogeneous network. By treating support-query pairs as dual perspectives, we introduce heterogeneous visual aggregation (HA) modules to enhance complementarity while preserving semantic commonality. To further reduce semantic noise and amplify the uniqueness of heterogeneous semantics, we design a heterogeneous transfer (HT) module. Finally, we propose heterogeneous CLIP (HC) textual information to enhance the generalization capability of multimodal models. In the weakly-supervised few-shot semantic segmentation (WFSS) task, with only 1/24 of the parameters of existing state-of-the-art models, TLG achieves a 13.2% improvement on Pascal-5\textsuperscript{i} and a 9.7% improvement on COCO-20\textsuperscript{i}. To the best of our knowledge, TLG is also the first weakly supervised (image-level) model that outperforms fully supervised (pixel-level) models under the same backbone architectures. The code is available at https://github.com/jarch-ma/TLG.

Semantic segmentation in open-vocabulary scenarios presents significant challenges due to the wide range and granularity of semantic categories. Existing weakly-supervised methods often rely on category-specific supervision and ill-suited feature construction methods for contrastive learning, leading to semantic misalignment and poor performance. In this work, we introduce a novel weakly-supervised approach, SynSeg, to address the challenges. SynSeg performs Multi-Category Contrastive Learning (MCCL) as a stronger training signal which robustly injecting intra- and inter-category knowledge during training. We also propose a new feature reconstruction framework named Feature Synergy Structure (FSS). FSS reconstructs discriminative features for contrastive learning through prior fusion and semantic-activation-map enhancement, effectively avoiding the foreground bias introduced by the visual encoder. Furthermore, SynSeg is a lightweight end-to-end solution capable for real-time inference. In general, SynSeg effectively improves the abilities in semantic localization and discrimination under weak supervision in an efficient manner. Extensive experiments on benchmarks demonstrate that our method outperforms state-of-the-art (SOTA) performance, with mIoU score gains ranging from 0.6% up to 8.9% across all reported benchmarks.

We propose a vision transformer (ViT)-based deep learning framework to refine disaster-affected area segmentation from remote sensing imagery, aiming to support and enhance the Emergent Value Added Product (EVAP) developed by the Taiwan Space Agency (TASA). The process starts with a small set of manually annotated regions. We then apply principal component analysis (PCA)-based feature space analysis and construct a confidence index (CI) to expand these labels, producing a weakly supervised training set. These expanded labels are then used to train ViT-based encoder-decoder models with multi-band inputs from Sentinel-2 and Formosat-5 imagery. Our architecture supports multiple decoder variants and multi-stage loss strategies to improve performance under limited supervision. During the evaluation, model predictions are compared with higher-resolution EVAP output to assess spatial coherence and segmentation consistency. Case studies on the 2022 Poyang Lake drought and the 2023 Rhodes wildfire demonstrate that our framework improves the smoothness and reliability of segmentation results, offering a scalable approach for disaster mapping when accurate ground truth is unavailable.