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Automated ICD-10 coding from clinical discharge summaries requires models that are both accurate on long-tailed multi-label classification tasks and interpretable to clinicians. Concept Bottleneck Models (CBMs) offer a principled framework for interpretability by routing predictions through human-interpretable concepts, but this transparency often comes at a cost: compressing rich clinical text representations into a narrow concept layer can restrict gradient flow and limit predictive capacity. We present ShifaMind, a concept-grounded architecture built around a Multiplicative Concept Bottleneck (MCB), which changes the form, rather than the width, of the bottleneck. Instead of projecting through a narrow concept layer, ShifaMind uses a learned multiplicative gate over a concept-grounded representation while retaining a scalar concept interface for inspection. On MIMIC-IV top-50 ICD-10 coding, ShifaMind achieves performance competitive with LAAT, the strongest baseline, across F1, AUC, and ranking metrics, while outperforming five additional ICD-coding baselines and providing concept-mediated explanations. Its substantial gains over a capacity-matched Vanilla CBM in both predictive performance and interpretability-oriented metrics highlight the importance of the bottleneck design.

The proliferation of large-scale and structurally complex data has spurred the integration of machine learning methods into statistical modeling. Recurrent neural networks (RNNs), a foundational class of models for time-dependent data, can be viewed as nonlinear extensions of classical autoregressive moving average models. Despite their flexibility and empirical success in machine learning, RNNs often suffer from limited interpretability and slow training, which hinders their use in statistics. This paper proposes the Parallelized RNN (ParaRNN), a novel model composed of multiple small recurrent units. ParaRNN admits an additive representation that decouples recurrent dynamics into interpretable components, whose behavior can be characterized through recurrence features. This interpretability enables its applications in nonparametric regression for time-dependent data, while the design also allows efficient parallelization. The approximation capacity and non-asymptotic prediction error bounds in a nonparametric regression setting are established for ParaRNN. Empirical results on three sequential modeling tasks further demonstrate that ParaRNN achieves performance comparable to vanilla RNNs while offering improved interpretability and efficiency.

Recent advances in large language models (LLMs) have led to the development of AI-powered tutoring systems that provide interactive support via dialogue. To enable these tutoring systems to provide personalized support, it is essential to assess student performance at each turn, motivating knowledge tracing (KT) in dialogue settings. However, existing dialogue-based KT approaches often ignore question difficulty modeling and rely on opaque latent representations from LLMs, hindering accurate and interpretable prediction. In this work, we propose an interpretable difficulty-aware conversational KT framework built upon LLMs, which explicitly models students' abilities and the difficulty of tutor-posed tasks at each turn. The framework incorporates the original textual question and the next tutor-posed task to estimate the student's knowledge state and the difficulty of the upcoming turn. Furthermore, it integrates Item Response Theory to map LLM's outputs into student ability and question difficulty parameters, enabling interpretable prediction of student performance grounded in cognitive theories of learning. We evaluate the framework on two tutor-student dialogue datasets. Both quantitative and qualitative results show that our framework outperforms existing KT baselines, meanwhile generating interpretable outputs consistent with cognitive theory.

The rapid spread of memes makes harmful content detection increasingly crucial, as effective identification can curb the circulation of misinformation. However, existing methods rely heavily on high-volume annotated data, which leads to substantial training costs and limited generalization. To address these challenges, we propose PrismAgent, a zero-shot, multi-agent, interpretable framework. PrismAgent conceptualizes this task as a criminal case investigation, employing four specialized agents responsible for the analysis, investigation, prosecution, and judgment stages within a structured collaborative workflow. In the first stage, the analyst agent paraphrases each meme under benevolent and malicious assumptions to probe its underlying intent. The investigator agent then retrieves supporting evidence from an unannotated dataset and constructs contextual interpretations for the meme and its variants. Next, the prosecutor agent performs three independent preliminary judgments by pairing the original meme with each of the three interpretations. Finally, the judge agent deliberates across all evidence to render a final verdict. Moreover, PrismAgent's explicit multi-stage reasoning chain makes the model inherently interpretable, as every intermediate step is explicitly explained rather than only producing a final detection result. Extensive experiments on three public datasets show that PrismAgent significantly outperforms existing zero-shot detection methods.

Catastrophic forgetting remains a fundamental challenge in continual learning, in which models often forget previous knowledge when fine-tuned on a new task. This issue is especially pronounced in class incremental learning (CIL), which is the most challenging setting in continual learning. Existing methods to address catastrophic forgetting often sacrifice either model interpretability or accuracy. To address this challenge, we introduce ClassIncremental Concept Bottleneck Model (CI-CBM), which leverage effective techniques, including concept regularization and pseudo-concept generation to maintain interpretable decision processes throughout incremental learning phases. Through extensive evaluation on seven datasets, CI-CBM achieves comparable performance to black-box models and outperforms previous interpretable approaches in CIL, with an average 36% accuracy gain. CICBM provides interpretable decisions on individual inputs and understandable global decision rules, as shown in our experiments, thereby demonstrating that human understandable concepts can be maintained during incremental learning without compromising model performance. Our approach is effective in both pretrained and non-pretrained scenarios; in the latter, the backbone is trained from scratch during the first learning phase. Code is publicly available at github.com/importAmir/CI-CBM.

Foundation models are used to extract transferable representations from large amounts of unlabeled data, typically via self-supervised learning (SSL). However, many of these models rely on architectures that offer limited interpretability, a critical issue in high-stakes domains such as medical imaging. We propose \model, a foundation model that is interpretable-by-design via a BagNet backbone whose small receptive fields generate class evidence maps that are faithful to the model's decision-making process. Additionally, \model{} incorporates a $2D$ projection layer during pretraining that enables direct visualization of the representation space, providing a dataset-level view of the learned structure including meaningful clinical clusters as well as potential spurious correlations. We trained \model{} on over 800,000 color fundus photographs from various sources to learn generalizable representations for different downstream tasks. Our model achieves performance comparable to RETFound, which has $16\times$ more parameters, while providing interpretable predictions on out-of-distribution data. These results suggest that large-scale SSL pretraining paired with inherent interpretability can lead to robust representations for retinal imaging. Code and pretrained models are available at \href{https://anonymous.4open.science/r/dual-ifm-3D5A/README.md}{www.anonymous.4open.science/dual-IFM}.

While dense biomedical embeddings achieve strong performance, their opaque dimensions limit transparency in biomedical NLP. Recent question-based interpretable embeddings represent text through binary answers to natural-language questions, but existing approaches rely primarily on corpus-driven signals, often capturing topical or stylistic differences rather than fine-grained biomedical distinctions. We propose QIME, an ontology-grounded framework for interpretable biomedical text embeddings in which each dimension corresponds to an explicit biomedical-domain yes/no question. QIME leverages a biomedical ontology to guide contrastive question generation from semantic clusters, producing atomic, domain-grounded questions. It constructs embeddings via similarity-based semantic activation with MMR-based diversity-aware dimension selection, yielding sparse representations efficiently. Experiments on biomedical clustering, STS and retrieval benchmarks show that QIME consistently outperforms prior interpretable embedding methods and substantially narrows the gap to strong black-box biomedical encoders. It also imposes substantially lower cognitive burden than existing methods, providing concise and domain-specific interpretations. The code is available at https://github.com/L1nzh/QIME.

Social scientists are increasingly turning to unstructured datasets to unlock new empirical insights, e.g., estimating descriptive statistics of or causal effects on quantitative measures derived from text, audio, or video data. In many settings, unsupervised analysis is of primary interest, in that the researcher does not want to (or cannot) manually pre-specify all important aspects of the unstructured data to measure; they are interested in "discovery." This paper proposes a general and flexible framework for pursuing such discovery from unstructured data in a statistically principled way. The framework leverages recent methods from the literature on AI interpretability to map unstructured data points to high-dimensional, sparse, and interpretable "concept embeddings"; computes statistics from these concept embeddings for testing interpretable, concept-by-concept hypotheses; performs selective inference on these hypotheses using algorithms validated by new results in high-dimensional central limit theory, producing a selected set ("discoveries"); and both generates and evaluates human-interpretable natural language descriptions of these discoveries. The proposed framework has few researcher degrees of freedom, is robust to data snooping and other post-selection inference concerns, and facilitates fast and inexpensive sensitivity analysis and replication. Applications to recent descriptive and causal analyses of unstructured data in empirical economics are explored.

Psychiatry research seeks to understand the manifestations of psychopathology in behavior, as measured in questionnaire data, by identifying a small number of latent factors that explain them. While factor analysis is the canonical tool for this purpose, the resulting factors may not be interpretable, and may also be subject to confounding variables. Moreover, missing data are common, and explicit imputation is often required. To overcome these limitations, we introduce Interpretability Constrained Questionnaire Factorization (ICQF), a non-negative matrix factorization method with regularization tailored for questionnaire data. Our method aims to promote factor interpretability and solution stability. We provide an optimization procedure with theoretical convergence guarantees, and an automated procedure to determine latent dimensionality accurately. We validate these procedures using realistic synthetic data. We demonstrate the effectiveness of our method in a widely used general-purpose questionnaire, in two independent datasets (the Healthy Brain Network and Adolescent Brain Cognitive Development studies). Specifically, we show that ICQF preserves diagnostic information across a range of disorders, outperforming competing methods for smaller dataset sizes, and improves interpretability, as assessed by our clinical research collaborators and co-authors. This suggests that the regularization in our method matches domain characteristics, in addition to satisfying qualitative desiderata.

Judicial reasoning remains challenging for large language models (LLMs) to analyze. This paper contributes a sentence-level benchmark for evaluating the ability of LLMs to classify interpretive canons as articulated by Larenz in the tradition of Savigny. Our contributions are threefold. First, we operationalize this conception of interpretation as classification criteria. Second, we provide a dataset of decisions of the German Federal Constitutional Court annotated at the sentence level. Third, we report baseline evaluations of four LLMs from three model families under expert hand-written prompts, compared against prompts optimized with Genetic-Pareto (GEPA). Mean F1 over the seven binary subtasks clusters between 70.4 and 79.2 across models, with grammatical interpretation usually the easiest canon to identify and systematic interpretation usually the hardest; under the tested configuration, GEPA-optimized prompts do not systematically outperform the hand-written ones, suggesting that the expert prompts provide a meaningful baseline.

Reward models are central to learning from human preferences, yet identifying what drives their predictions remains challenging. Recent sparse Mixture-of-Experts (MoE) reward models seek to improve interpretability by routing prompts to specialized experts and characterizing experts through examples with high routing weights. However, routing weights only reveal which prompts an expert $\textit{receives}$, not how it $\textit{judges}$ responses, providing only a partial account of expert behavior. We therefore propose $\textbf{Co}$ntribution-$\textbf{Co}$ntrast ($\textbf{CoCo}$) response-level interpretation, which faithfully characterizes experts' roles using chosen-rejected response pairs with the largest contribution contrasts, jointly capturing routing and preference behavior. Across automatic and human evaluations, CoCo yields more coherent, faithful, and specialized interpretations than router-based, score-based, and sparse autoencoder-based alternatives while maintaining competitive reward modeling accuracy. To the best of our knowledge, this is the first systematic study of interpretation methods for MoE reward models.

Large vision-language models have improved at describing visual content, but accurate descriptions do not ensure interpretation when meaning depends on knowledge beyond the pixels. Memes expose this gap because they rely on cultural entities, background knowledge, and community conventions. Most meme benchmarks reduce interpretation to labels or holistic scores, obscuring where an explanation breaks down. We introduce MemeBench, a diagnostic benchmark of 1,253 Chinese and English memes with human-written references and quality-controlled VIKR annotations, centered on anime, comics, games, and adjacent online subcultures. Its VIKR schema decomposes explanations into Visual clues, Identity links, Knowledge units, and Reasoning mechanisms. Across 26 LVLMs, every model covers visible content more reliably than the knowledge needed to interpret it, and even the strongest retains a 22.6% Visual-Knowledge gap. To test whether this diagnosis can guide improvement, we introduce KAR, an entity-guided retrieval baseline built on CultureBase. Across four controlled models, KAR raises VIKR Success by 3.6-7.4% and, compared with generic retrieval, repairs more answers and breaks fewer. Yet both retrieval conditions improve Identity and Knowledge while reducing Visual coverage in every comparison. MemeBench reveals whether an interpretation succeeds, what is missing, and whether targeted evidence fills the diagnosed gap.

The interpretation phase of life cycle assessment often lacks structured mechanisms for translating quantified improvement opportunities addressing environmental hotspots into actionable strategic pathways under technological, social, and policy uncertainty. To overcome this limitation, this study introduces a perspective-conditioned retrieval-augmented generation framework for LCA interpretation, where a multi-perspective retrieval and controlled synthesis is incorporated in the artificial intelligence (AI)-assisted LCA. To operationalise large language models in LCA interpretation, a perspective fusion RAG architecture was developed, covering academic, industry, public discourse, and European union (EU) funding datasets. Our approach comprises three steps: (1) a scenario anchor defining system boundaries and decarbonization targets, (2) a set of perspective-specific micro-queries with constrained retrieval, and (3) a neutral synthesis step integrating only ledger-stored outputs without further retrieval. The framework is demonstrated through a hydrogen-enabled diesel reduction use case in an Italian apple production facility using GPT-5 nano as the reasoning model. Overall, the structured retrieval and constrained synthesis are designed to mitigate the risk of hallucination while preserving cross-domain diversity. The approach presented can support more disciplined translation of impact results into strategic pathways and opens up new avenues for the use of advanced AI tools in LCA studies, particularly those focused on technologies that could be deployed at scale. This proof-of-concept demonstrates how AI-assisted, evidence-grounded interpretation can support implementation-oriented decision-making beyond conventional LCA studies.

Neural Combinatorial Optimization (NCO) achieves strong performance, yet its black-box nature remains a key roadblock to deployment and scientific diagnosis. Standard interpretability tools, such as Concept Bottleneck Models (CBMs), are ill-equipped for NCO, whose decisions are dynamic, state-dependent, and lack proper concept vocabulary definition. To close this gap, we introduce Evolving Programmatic Bottlenecks (EPB), to our knowledge, the first framework for interpreting NCO policies by distilling black-box NCO models into human-readable program portfolios. EPB employs an LLM to autonomously evolve a bank of programs, where each program's per-step action distribution serves as the bottleneck. EPB works through an iterative framework: Block I fixes program bank capacity and introduces a hybrid textual-numerical gradient descent scheme that couples numerical gradients for student router updates and textual gradients for LLM-based program revision; Block II dynamically adapts bank capacity via fault-targeted expansion and redundancy pruning. Extensive experiments demonstrate EPB's effectiveness and broad applicability, where the distilled program portfolios largely match original performance. EPB also reveals that NCO behavior shifts across optimization stages and can be approximated as a composition of classic heuristic variants. Our work advances interpretable NCO and establishes EPB as a promising tool for interpreting sequential decision-making models.

A prominent research direction in mechanistic interpretability is learning sparse circuits over LLM components to reveal how they jointly produce model behavior. However, raw neurons are polysemantic, making learned circuits hard to interpret. Sparse autoencoder (SAE) features alleviate this, but their high dimensionality makes existing intervention-based circuit learning methods computationally prohibitive. We propose CircuitLasso, a scalable circuit-learning approach based on sparse linear regression. CircuitLasso recovers circuits whose structural accuracy matches that of state-of-the-art intervention-based methods on the benchmark data, at a fraction of the computational cost. For interpretability, CircuitLasso efficiently uncovers relationships among SAE features, showing how human-interpretable semantic features propagate through the model and influence its predictions. Finally, we validate the utility of our learned circuits by leveraging their insights to achieve comparable performance at substantially lower cost on a domain-generalization task.

Frame analysis of migration news is a socially consequential task: media scholars and researchers who study how migration is narrated need tools that are not only accurate, but transparent, auditable, and accessible within the resource constraints typical of academic research groups. Existing LLM-based approaches rely on proprietary APIs and large models that raise concerns about data privacy, reproducibility and equitable access among media researchers. This work studies how a locally deployable open-source LLM can support interpretable frame analysis as an assistive tool. We introduce a Structured Chain-of-Thought (SCoT) prompting approach using Llama3-8B, enabling step-by-step justifications grounded in predefined framing categories. This structured design allows users to audit model outputs and examine alternative interpretations in a task that is inherently subjective. We evaluate our approach on a dataset of migration-related news and show that SCoT improves classification performance over zero-shot and few-shot baselines while remaining feasible on a single GPU. Then, we conduct a human-centered evaluation in which annotators assess the coherence and influence of "the model's reasoning". Results indicate that SCoT explanations are generally perceived as logical (mean score 4.1/5, though with notable variation across texts) and can prompt reflection on initial interpretations, even when disagreement persists. Our findings highlight both the potential and risks of LLM-assisted frame analysis. While structured reasoning can increase the traceability of model outputs and support critical interpretation, it can also influence human judgment in subtle ways. By enabling local deployment and emphasizing human-in-the-loop interaction, this work contributes to discussions on responsible and accessible computational tools for the study of socially impactful media narratives.

Large Language Models (LLMs) are being rapidly adopted in agricultural imaging applications, ranging from crop interpretation to synthetic field image generation. However, these models frequently exhibit hallucinations outputs that appear confident yet deviate from biological or environmental reality potentially leading to misinformed agronomic insights. This study investigates such hallucinations in two complementary directions: image-to-text, where LLMs interpret crop or field imagery to describe conditions such as biotic and abiotic stresses, and text-to-image, where models generate synthetic agricultural scenes based on descriptive prompts. We examine errors involving biological inconsistency, contextual inaccuracy, and agronomic implausibility, evaluating the outputs under domain-informed criteria across multiple imaging modalities. Our analysis identifies recurring hallucination patterns within both interpretive and generative tasks. In image interpretation, LLMs (e.g., Gemma, LLAVA, Qwen, and MiniCPM) achieved modest zero-shot accuracy (63 to 75 percent), whereas few-shot prompting improved performance up to 86.8 percent, exhibiting false detections and missed infections, indicating residual hallucination effects. In text-to-image tasks, advanced models such as GPT-5 and Gemini 2.5 Flash generate up to 91 percent biologically inconsistent scenes under relaxed prompt constraints, revealing fundamental weaknesses in current LLMs. This systematic assessment of visual reasoning and generation offers critical insights toward enhancing the reliability and trustworthiness of LLM-based agricultural imaging platforms.

Concept Bottleneck Models (CBMs) in medical imaging aim to improve model interpretability by predicting intermediate clinical concepts before final diagnoses. However, most existing CBMs treat concepts as discriminative predictors of pathology labels, without explicitly modelling the underlying clinical generative process where diseases produce observable radiographic findings. We propose XpertCausal, a radiologist-guided causal CBM for chest X-ray interpretation which models pathology-to-concept relationships using a probabilistic noisy-OR framework. This generative model is then inverted via Bayesian inference to estimate pathology probabilities from predicted concepts. Radiologist-curated concept-pathology associations are used to constrain model structure to radiologist-defined clinically plausible reasoning pathways. We evaluate XpertCausal on MIMIC-CXR across pathology classification performance, calibration, explanation quality, and alignment with radiologist-defined reasoning pathways. Compared with both a non-causal CBM baseline and a causal ablation with unconstrained learned associations, XpertCausal achieves improved AUROC, calibration, and clinically relevant explanation quality, while learning concept-pathology relationships that more closely align with expert knowledge. These results demonstrate that incorporating clinically motivated causal structure and expert domain knowledge into CBMs can lead to more accurate, interpretable, and clinically aligned models for CXR interpretation.

Peripheral Blood Smear (PBS) is a critical microscopic examination in hematopathology that yields whole-slide imaging (WSI). Unlike solid tissue pathology, PBS interpretation focuses on individual cell morphologies rather than tissue architecture, making it distinct in both visual characteristics and diagnostic reasoning. However, current multimodal large language models (MLLMs) for pathology are primarily developed on solid-tissue WSIs and struggle to generalize to PBS. To bridge this gap, we construct PBSInstr, the first vision-language dataset for PBS interpretation, comprising 353 PBS WSIs paired with microscopic impression paragraphs and 29k cell-level image crops annotated with cell type labels and morphological descriptions. To facilitate instruction tuning, PBSInstr further includes 27k question-answer (QA) pairs for cell crops and 1,286 QA pairs for PBS slides. Building upon PBSInstr, we develop PBS-VL, a hematopathology-tailored vision-language model for multi-level PBS interpretation at both cell and slide levels. To comprehensively evaluate PBS understanding, we construct PBSBench, a visual question answering (VQA) benchmark featuring four question categories and six PBS interpretation tasks. Experiments show that PBS-VL outperforms existing general-purpose and pathology MLLMs, underscoring the value of PBS-specific data. We release our code, datasets, and model weights to facilitate future research. Our proposed framework lays the foundation for developing practical AI assistants supporting decision-making in hematopathology.

Vision-language models (VLM) have markedly advanced AI-driven interpretation and reporting of complex medical imaging, such as computed tomography (CT). Yet, existing methods largely relegate clinicians to passive observers of final outputs, offering no interpretable reasoning trace for them to inspect, validate, or refine. To address this, we introduce RadAgent, a tool-using AI agent that generates CT reports through a stepwise and interpretable process. Each resulting report is accompanied by a fully inspectable trace of intermediate decisions and tool interactions, allowing clinicians to examine how the reported findings are derived. In our experiments, we observe that RadAgent improves chest CT report generation over its 3D VLM counterpart, CT-Chat, across three dimensions. Clinical accuracy improves by 5.8 points (35.4% relative) in macro-F1 and 5.1 points (18.6% relative) in micro-F1. Robustness under adversarial conditions improves by 24.7 points (41.9% relative). Furthermore, RadAgent achieves 37.0% in faithfulness, a new capability entirely absent in its 3D VLM counterpart. By structuring the interpretation of chest CT as an explicit, tool-augmented and iterative reasoning trace, RadAgent brings us closer toward transparent and reliable AI for radiology.

Grad-ECLIP is published at ICML 2024 and represents a new Transformer interpretation technical route (intermediate features-based). First, this paper demonstrates that the intermediate features-based technical route is not a novel one. Based on the existing attention-based route, we have developed Attention-ECLIP, which is completely equivalent to Grad-ECLIP but with simpler computation. Both through formal derivation and experimental validation, we prove that the intermediate feature-based route represented by Grad-ECLIP is actually an equivalent variant of the attention-based route. Next, this paper demonstrates that the Grad-ECLIP method is flawed. The model interpretation results obtained by Grad-ECLIP are not those of the original model, and the interpretation results are misaligned with the model's performance. We analyze the causes of Grad-ECLIP's flaws and propose, or rather, explicitly emphasize two fundamental principles that model interpretation should adhere to in order to avoid similar errors.

Concept bottleneck models (CBMs) can improve the transparency of cancer image diagnostic prediction by expressing predictions through radiological concepts. However, their dependence on instance-level concept annotations limits practical applicability. We propose a prior-guided hybrid CBM that integrates limited concept annotations, class-conditional concept distribution matching on unannotated patients, and prior initialization of the concept-to-diagnosis head. We evaluate the method on CBIS-DDSM mammographic masses and calcifications and LIDC-IDRI pulmonary nodules across 0-100% concept annotation. In the clinically relevant 0-20% annotation regime, the hybrid CBM consistently improves mean concept AUC over a matched standard CBM, while maintaining diagnostic performance close to black-box models. At 10% annotation specifically, concept AUC increases from 0.619 to 0.741 for masses, from 0.650 to 0.787 for calcifications, and from 0.597 to 0.642 for pulmonary nodules. Ablation experiments identify prior initialization as the main component contributing to improved concept detection, likely by stabilizing the concept-to-diagnosis head. Zero-shot VLMs remain insufficient for reliable fine-grained tumor-level concept prediction. These findings suggest that structured priors can substantially reduce the annotation burden of interpretable cancer imaging models.

Radio-frequency (RF) monitoring is essential for space domain awareness, but it often generates large, variable, and sparsely populated datasets with few labels. These observations can capture satellites, space debris, and the ionospheric background, yet interpreting them typically requires specialized subject-matter expertise. Supervised deep learning methods can perform well on labeled RF data, but they require many annotated examples and may need careful retraining as RF conditions change. Semi-supervised approaches offer a practical alternative for limited-data settings by using unlabeled observations to reveal latent patterns that experts can interpret. In this paper, we present a semi-supervised RF detection and classification workflow for satellite monitoring that combines Non-negative Matrix Factorization with automatic model determination (NMFk), expert-guided cluster interpretation, and classifier-based prediction. We first represent RF observations as a non-negative feature matrix and apply NMFk to estimate the number of clusters that best captures patterns in the unlabeled data. Subject-matter experts then assign physical meaning to the resulting clusters, including satellite detections, ionospheric environmental conditions, and other RF event categories. Finally, we train a classifier on these interpreted clusters to evaluate performance on a test set and categorize future observations. This pipeline reduces reliance on large pre-labeled datasets by pairing unsupervised factorization with expert interpretation, enabling an interpretable and transferable methodology for detecting, observing, and classifying behavior in RF data.

Recent advances in Deep Learning (DL) have strengthened data-driven System Identification (SysID), with Neural and Fuzzy Ordinary Differential Equation (NODE/FODE) models achieving high accuracy in nonlinear dynamic modeling. Yet, system states in these frameworks are often reconstructed without clear physical meaning, and input contributions to the state derivatives remain difficult to interpret. To address these limitations, we propose Explainable FODE (xFODE), an interpretable SysID framework with integrated DL-based training. In xFODE, we define states in an incremental form to provide them with physical meanings. We employ fuzzy additive models to approximate the state derivative, thereby enhancing interpretability per input. To provide further interpretability, Partitioning Strategies (PSs) are developed, enabling the training of fuzzy additive models with explainability. By structuring the antecedent space during training so that only two consecutive rules are activated for any given input, PSs not only yield lower complexity for local inference but also enhance the interpretability of the antecedent space. To train xFODE, we present a DL framework with parameterized membership function learning that supports end-to-end optimization. Across benchmark SysID datasets, xFODE matches the accuracy of NODE, FODE, and NLARX models while providing interpretable insights.

Intelligent spectroscopy serves as a pivotal element in AI-driven closed-loop scientific discovery, functioning as the critical bridge between matter structure and artificial intelligence. However, conventional expert-dependent spectral interpretation encounters substantial hurdles, including susceptibility to human bias and error, dependence on limited specialized expertise, and variability across interpreters. To address these challenges, we propose SpecXMaster, an intelligent framework leveraging Agentic Reinforcement Learning (RL) for NMR molecular spectral interpretation. SpecXMaster enables automated extraction of multiplicity information from both 1H and 13C spectra directly from raw FID (free induction decay) data. This end-to-end pipeline enables fully automated interpretation of NMR spectra into chemical structures. It demonstrates superior performance across multiple public NMR interpretation benchmarks and has been refined through iterative evaluations by professional chemical spectroscopists. We believe that SpecXMaster, as a novel methodological paradigm for spectral interpretation, will have a profound impact on the organic chemistry community.

Prototype-based neural networks provide inherent interpretability through case-based reasoning, yet suffer from critical limitations: prototypes converge to redundant features, fail to capture diverse semantic parts, and lack quantitative interpretability assessment. We propose Diversity-Aware Prototype Learning (DAPL), which enforces prototype diversity through architectural constraints rather than explicit regularization. Our approach leverages multi-head self-attention with strict one-to-one attention-to-prototype mapping, ensuring each prototype specializes in distinct visual features. We further introduce foreground-aware training to focus prototypes on semantically meaningful regions and develop comprehensive evaluation metrics (Coverage and Diversity) for quantitative interpretability assessment. Experiments on CUB-200-2011 demonstrate substantial improvements: DAPL with foreground-aware training achieves 81.69% accuracy with 0.596 Coverage and 0.427 Diversity, providing the best overall balance across all evaluated prototype-based methods. Code is available at https://github.com/xinmiaolin/DAPL.

Reinforcement learning (RL) is widely utilized in large language model training to improve targeted capabilities, yet how RL reshapes a model remains poorly understood. Prior attempts to explain how RL works largely offer behavioral perspectives, leaving open what RL gives a model at the representation level: can RL create genuinely novel features, and which existing features does it enhance or suppress? Recent developments in mechanistic interpretability suggest sparse autoencoders (SAEs) as a promising lens to decompose internal activations into human-interpretable features; however, they cannot be directly applied to tracking change across training. In this work, we introduce Fixed-SAE Track, a framework that trains one shared SAE per considered layer on activations pooled across the base model and all RL checkpoints, holding every feature direction fixed so that representation shifts are rigorously defined through the activations of interpretable SAE latents, including the detection of emerging novel features. Validated across multiple datasets and RL algorithms, we find that RL-induced drift is small, gradual, concept specific, and concentrated in late layers, mainly enhancing the sampling rates of a small set of ladder tokens, formatting scaffolding such as step breaks and answer delimiters, rather than reshaping problem content. Steering these features into the base model recovers around 80% of RL's performance gain, suggesting that RL primarily elicits capabilities the model already possesses, much as steering does. We further design a synthetic benchmark with features known by construction to test whether RL can instill genuinely novel features. We believe Fixed-SAE Track provides a principled approach to tracking representation shifts and offers representational evidence for understanding how reinforcement learning changes the inner representation of LLMs.

This paper presents Murano, an open source framework for designing, running, and reproducing mechanistic interpretability studies of large language models, intended for researchers across disciplines. These studies often combine loading, recording, attribution, intervention, and evaluation, while existing libraries tend to focus on different parts of this workflow. As a result, researchers using several libraries may need to adapt outputs from one for use by another. To bridge this gap, Murano represents operations from these five areas as composable steps. Steps exchange named result artifacts and declare the inputs they require and the outputs they produce. A pipeline executes its steps in the order supplied, and Murano uses canonical addresses when component identities pass between operations. Murano builds on existing interpretability and machine learning libraries. We demonstrate Murano through two reproductions of established interpretability studies and one illustrative sparse autoencoder case study.

The adaptive neuro-fuzzy inference system (ANFIS) is an interpretable reasoning framework capable of generating explicit IF-THEN fuzzy rules, making it suitable for tasks requiring transparent reasoning. However, existing ANFIS models generally construct rule antecedents and perform inference in Euclidean space, limiting their representational capacity and predictive performance. To address this issue, we propose Hyperbolic ANFIS (HyperANFIS), a hyperbolic extension of ANFIS. HyperANFIS preserves the fuzzy semantics and core architecture of conventional ANFIS while performing rule-prototype learning, rule activation, and consequent aggregation in hyperbolic space. It also retains the ability to generate interpretable IF-THEN rules. By exploiting the representational properties of hyperbolic geometry, HyperANFIS strengthens the fuzzy inference process, thereby improving predictive accuracy, inter-rule collaboration, and the credibility of its interpretable rules. Experimental results show that HyperANFIS consistently outperforms the standard ANFIS baseline and various ANFIS variants across all datasets, while also generating higher-quality fuzzy rules.

Mechanistic interpretability explains models by identifying circuits inside them, but has no way to tell whether a circuit is a property of the model or an artifact of the method that found it. Sparse autoencoders illustrate the problem: different seeds and widths recover materially different features from the same activations, and no theory says whether that variability is incidental or structural. We put dictionary learning for interpretability on an identifiability footing. Treating the forward pass as a controlled dynamical system with depth as time and lifting it with the Koopman operator yields a finite linear realisation whose \emph{spectrum} is a coordinate-free property of the model. We prove the spectrum is recoverable from $M$ calibration samples at rate $M^{-1/2}$ up to permutation - to our knowledge the first identifiability theorem for a mechanistic-interpretability primitive, with a matching minimax lower bound, a median-of-means variant for heavy-tailed activations, and a dissociation theorem: whenever the realisation is non-normal, the directions carrying activation variance and the directions carrying information across depth cannot coincide. The identifiable object and the legible object are not the same object. On GPT-2 small, Gemma-2-2B and Qwen3-8B-Base the spectrum converges everywhere and attains the predicted exponent on Qwen3-8B-Base ($0.506 \pm 0.031$); shortfalls collapse onto one curve against each cell's sample threshold. Koopman modes beat random directions but lose to principal components on indirect-object identification, with the gap decaying $4.1\times$ in depth-distance, as the theorem predicts. The Koopman spectrum is an identifiable, model-intrinsic fingerprint with a stated error bar, not a legible decomposition.