AI-Assisted Scientific Research

Overview

The field studies how AI can help across the research process, from finding and synthesizing literature to proposing ideas, analyzing data, writing code, and planning experiments. Common approaches include retrieval-augmented language models, knowledge graphs, tool-using multi-agent systems, and domain-specific models for areas such as chemistry, biology, and astronomy. Evaluation ranges from literature and coding benchmarks to reproducibility tests and prospective laboratory or field studies. AI is often useful for structured, tool-mediated tasks, but open-ended discovery, reliable screening, calibrated uncertainty, and faithful experimental validation remain difficult, making provenance and human oversight central.

Latest papers

CardsList

253 papers25 papers in the last four weeks, down 7% on the four weeks before. 0.1% of all new papers.

  1. ASTER -- Agentic Science Toolkit for Exoplanet Research

    Mar 27, 2026Emilie Panek, Alexander Roman, Gaurav Shukla +3AI-Assisted Scientific ResearchLLM Agent Orchestration

  2. How Open Must Language Models be to Enable Reliable Scientific Inference?

    Mar 27, 2026James A. Michaelov, Catherine Arnett, Tyler A. Chang +7AI-Assisted Scientific ResearchLLM Reliability

  3. Hierarchy-Guided Multimodal Representation Learning for Taxonomic Inference

    Mar 26, 2026Sk Miraj Ahmed, Xi Yu, Yunqi Li +2Hierarchical Representation LearningMultimodal Robustness

  4. BioVITA: Biological Dataset, Model, and Benchmark for Visual-Textual-Acoustic Alignment

    Mar 25, 2026Risa Shinoda, Kaede Shiohara, Nakamasa Inoue +3Cross-Modal AlignmentMultimodal Embedding

  5. AwesomeLit: Towards Hypothesis Generation with Agent-Supported Literature Research

    Mar 23, 2026Zefei Xie, Yuhan Guo, Kai XuAI-Assisted Scientific ResearchResearch Idea Generation

  6. Research Novelty in Information Systems Journals After ChatGPT: Differences Across Institutional Language Contexts

    Mar 23, 2026Ali Safari, Sahar BabaeiAI-Assisted Scientific Research

  7. On the Carbon Footprint of Economic Research in the Age of Generative AI

    Mar 17, 2026Andres Alonso-Robisco, Carlos Esparcia, Francisco JareñoAI-Assisted Scientific ResearchResponsible AI

  8. The Agentic Researcher: A Practical Guide to AI-Assisted Research in Mathematics and Machine Learning

    Mar 16, 2026Max Zimmer, Nico Pelleriti, Christophe Roux +1AI-Assisted Scientific ResearchAutonomous Research Agents

  9. An Empirical Investigation of Pre-Trained Deep Learning Model Reuse in the Scientific Process

    Mar 13, 2026Nicholas M. Synovic, Karolina Ryzka, Alessandra V. Vellucci Solari +3AI-Assisted Scientific ResearchTransfer Learning

  10. RetroReasoner: A Reasoning LLM for Strategic Retrosynthesis Prediction

    Mar 13, 2026Hanbum Ko, Chanhui Lee, Ye Rin Kim +4AI-Assisted Scientific ResearchLanguage Modeling

  11. OpenExtract: Automated Data Extraction for Systematic Reviews in Health

    Mar 6, 2026Jim Achterberg, Bram Van Dijk, Jing Meng +8Systematic Review AutomationDocument Information Extraction

  12. ResearchEnvBench: Benchmarking Agents on Environment Synthesis for Research Code Execution

    Mar 6, 2026Yubang Wang, Chenxi Zhang, Bowen Chen +7AI Agent BenchmarksAutonomous Research Agents

  13. .tmu: A Low-Entropy Tree-Structured Representation for LLM-Assisted Scientific Writing

    Mar 3, 2026Tianyou Liu, Ziqiang Li, Xurui Liu +2AI-Assisted Scientific ResearchLLM Training

  14. Inference-time optimization for experiment-grounded protein ensemble generation

    Feb 27, 2026Advaith Maddipatla, Anar Rzayev, Marco Pegoraro +5Diffusion Model GuidanceInference-Time Optimization

  15. LLM Novice Uplift on Dual-Use, In Silico Biology Tasks

    Feb 26, 2026Chen Bo Calvin Zhang, Christina Q. Knight, Nicholas Kruus +16AI-Assisted Scientific ResearchLLM Safety Evaluation

  16. CiteLLM: An Agentic Platform for Trustworthy Scientific Reference Discovery

    Feb 26, 2026Mengze Hong, Di Jiang, Chen Jason Zhang +5AI-Assisted Scientific ResearchCitation Verification

  17. The AI Research Assistant: Promise, Peril, and a Proof of Concept

    Feb 26, 2026Tan Bui-ThanhAI-Assisted Scientific ResearchHuman-AI Collaboration

  18. Many AI Analysts, One Dataset: Navigating the Agentic Data Science Multiverse

    Feb 21, 2026Martin Bertran, Riccardo Fogliato, Zhiwei Steven WuAI-Assisted Scientific ResearchData Analysis Agents

  19. From Labor to Collaboration: A Methodological Experiment Using AI Agents to Augment Research Perspectives in Taiwan's Humanities and Social Sciences

    Feb 19, 2026Yi-Chih HuangAgentic WorkflowsHuman-AI Collaboration

  20. Measuring Mid-2025 LLM-Assistance on Novice Performance in Biology

    Feb 18, 2026Shen Zhou Hong, Alex Kleinman, Alyssa Mathiowetz +9AI-Assisted Scientific ResearchHuman-in-the-Loop AI

  21. Two Stages of Folding: Convergent Mechanisms in AI Protein Folding Trunks

    Feb 5, 2026Kevin Lu, Jannik Brinkmann, Stefan Huber +4Protein Structure PredictionAI-Assisted Scientific Research

  22. The Rise of Large Language Models and the Direction and Impact of US Federal Research Funding

    Jan 21, 2026Yifan Qian, Zhe Wen, Alexander C. Furnas +3AI-Assisted Scientific Research