Cross-Modal Image Registration

Overview

Cross-modal image registration estimates how images from different sources—such as MRI and CT, infrared and visible light, or cameras and point clouds—overlap in space. Methods range from mutual-information and anatomical-feature matching to learned shared representations, coarse-to-fine correspondence networks, and geometry- or uncertainty-aware optimization; they may estimate rigid poses, local deformations, or both. The goal is to transfer information reliably across modalities for tasks such as image fusion, navigation, and measurement, including when appearance, viewpoint, or tissue shape differs. A central challenge is that stronger overlap scores do not always mean anatomically or geometrically correct alignment, so generalization and task-specific evaluation remain important.

Latest papers

70 papers9 papers in the last four weeks, down 25% on the four weeks before. 0.1% of all new papers.

Aug 12, 2026

Warping Earth Observations for better ice labeling in the Marginal Marginal Ice Zone

Multimodal satellite imagery provides complementary information for Earth Observation, but accurately combining heterogeneous sensors remains challenging in dynamic environments. Fast-changing regions, such as the Antarctic marginal ice zone, cannot fully exploit multimodal information from different satellite sensors because surface features move between image acquisitions. This spatial and temporal mismatch challenges effective perceptual grounding, violating the assumption of pixel-level correspondence that underpins most multimodal reasoning and downstream classification pipelines. Antarctic sea ice provides a challenging benchmark due to the rapid, heterogeneous drift of individual ice floes and the differing responses of sea ice to radar, visible and thermal sensing modalities. Accurate, dense supervision of sea ice remains scarce because generating pixel-wise labels requires time-consuming expert interpretation of noisy data, leading to historical reliance on coarse-resolution maritime ice charts for model training. This paper presents a novel architecture based on mutual information warping to align multi-satellite (Sentinel-1 and MODIS platforms) multimodal (visible, thermal, radar) satellite scenes. To demonstrate the approach, we introduce a sparse expert-labeled dataset of 2,088 pixel-wise annotations (7,046 expert point classifications) located at the ice-water margin interface across 43 scenes. Our results demonstrate that spatially grounding and aligning modalities prior to segmentation improves classification accuracy, and enables accurate, dense sea ice segmentation from sparse point-wise supervision.
Aug 11, 2026

Bridging Severe Cross-Modal Misalignment: End-to-End Visible-Infrared Object Detection via Explicit Feature-Domain Affine Registration

Visible-infrared object detection relies on complementary RGB and thermal cues, but its performance is often degraded by cross-modal spatial misalignment. Most existing methods rely on implicit feature adaptation to handle weakly misaligned scenarios, while large-offset geometric discrepancies remain insufficiently addressed. In this paper, we propose a Joint Feature-domain Registration and Detection network (JFRDet), an end-to-end visible-infrared oriented object detector tailored for severely cross-modal geometric discrepancies. JFRDet introduces a Cross-Modal Affine Alignment (CMAA) module to estimate an image-level affine transformation for explicit multi-level feature alignment. Note that illumination changes directly affect the reliability of RGB cues, an Illumination-Guided Complementary Fusion (IGCF) module adaptively exploits modality reliability under varying illumination conditions for cross-modal fusion. Then, an Alignment Quality-Consistency Gating (AQCG) strategy stabilizes joint optimization by modulating detection supervision according to alignment reliability and gradient consistency. We further construct DroneVehicle Misaligned (DVMA), a benchmark for evaluating visible-infrared oriented object detection under severe cross-modal geometric misalignment. The proposed JFRDet achieves 69.7% mAP50\mathrm{mAP}_{50} on DVMA, which represents state-of-the-art (SOTA) performance. The code and dataset will be available on GitHub.
Aug 7, 2026

APCReg: Anatomical-Prior-Guided Coarse-to-Fine CBCT--IOS Registration via Multi-View Projection and Reliability-Controlled Residual Correction

Registration between cone-beam computed tomography (CBCT) and intraoral scans (IOS) is essential for patient-specific surgical planning. However, disparate imaging modalities, limited overlap, and large pose offsets make automated registration unreliable. Consequently, clinical registration remains dependent on conventional geometry pipelines and manual clinician adjustment. To address these challenges, we propose APCReg, an anatomical-prior-guided coarse-to-fine framework for global registration and reliability-controlled residual correction. Specifically, multi-view anatomical coarse registration (MACR) performs ordered orthogonal projection alignment (buccal, proximal, and occlusal) to decompose the six-degree-of-freedom search before three-dimensional refinement. Overlap-aware residual registration (OARR) combines shared KPConv features, a folded arch-length cue, overlap-gated cross-attention, and Sinkhorn matching. Finally, dental-arch-structured hypothesis selection evaluates diverse poses on held-out reliable correspondences, while a ground-truth-free coarse-retention guard conditionally retains a geometrically reliable coarse pose. On 60 held-out jaw pairs, APCReg achieves a submillimeter mean Chamfer distance of 0.87 mm and a Hausdorff distance of 2.92 mm under this evaluation protocol, and ranks first across the six reported metrics among the evaluated open-source baselines.
Aug 3, 2026

Coarse-to-Fine Registration of Jawbone CT and Intraoral Scan Data Using GeDi and ICP with Pseudo-IOS Ground Truth

In digital dentistry and oral surgery, the registration of jawbone CT and intraoral scanner (IOS) data is essential for integrating internal bone structure with high-resolution dental surface geometry. However, this registration is challenging because the two modalities share only a limited region in common, and their true correspondence is generally unknown. This uncertainty has prevented rigorous quantitative evaluation of registration accuracy. In this study, we propose a pseudoIOS evaluation framework in which a point cloud emulating an intraoral scan is generated from CT data within the same coordinate frame, so that the transformation between them is known by construction and can serve as a true ground truth. Using this framework, we propose a coarse-to-fine registration method that combines a domain-generalizable local descriptor (GeDi) for initialization-independent global alignment with the iterative closest point (ICP) algorithm for local refinement, and also evaluate the influence of metal artifacts on registration. In experiments on seven cases, ICP alone frequently converged to local minima from a perturbed initial position, whereas GeDi++ICP maintained submillimeter mean absolute error (MAE) across all evaluated jaw and artifact conditions (0.55-0.69 mm). A three-way repeated-measures analysis confirmed that GeDi++ICP was significantly more accurate than GeDi alone. Metal artifacts had a statistically detectable overall effect, but their absolute impact on GeDi++ICP was small.
Jul 19, 2026

Cross-Coordinate Correspondence Pruning for Image-to-Point Cloud Registration

Recent detection-free approaches have shown significant efficacy in image-to-point cloud (I2P) registration by employing a coarse-to-fine matching pipeline. In the coarse stage, down-sampled image features and voxelized point cloud features are typically fused to establish initial coarse correspondences for subsequent refinement. However, existing methods largely overlook the critical role of point cloud density, which fundamentally dictates the quality of coarse correspondences and the final registration results. Specifically, excessively sparse point clouds lead to an insufficient number of inliers, while overly dense ones often introduce a high outlier ratio. Consequently, this creates an inherent density trade-off, thereby significantly limiting the registration accuracy of current approaches. For mitigating this trade-off, we propose a novel Cross-Coordinate Correspondences Pruning (CCP) strategy to acquire sufficient inliers while ensuring a low outlier ratio. To minimize interference from inter-modal coordinate discrepancies, we first project cross-coordinate coarse correspondences to the 2D image coordinate system for spatial unification. Subsequently, a lightweight pruning network is responsible for predicting the inlier confidences, which are used to filter coarse outliers, from coordinate geometric and modal feature dimensions. To maximize inlier recall, we further design a Multi-Density Point Ensemble (MDPE) strategy that consolidates and deduplicates pruned coarse correspondences across varying point cloud densities. Our method achieves a significant performance improvement, surpassing existing state-of-the-art methods by at least 8.6% in Registration Recall across various benchmarks.
Jul 16, 2026

Image-to-Point Cloud Registration Made Easy with Rectified Flow-based LiDAR Upsampling

Image-to-Point Cloud Registration (I2P) is essential for integrating camera and LiDAR in perception and autonomous systems, yet the modality gap between images and point clouds makes it difficult to achieve both high accuracy and strong generalization. In this paper, we propose a simple yet effective I2P method that treats LiDAR as an imaging sensor: from a single sparse LiDAR scan, we generate a dense LiDAR intensity image using Conditional Rectified Flow, match it with a camera image using a pre-trained feature matcher, and estimate the 6-DoF relative pose via PnP-RANSAC. The proposed model is pre-trained through a self-supervised image completion task and fine-tuned on a small amount of LiDAR data (neither image-point cloud pairs nor ground-truth sensor poses are required), enabling it to scale to diverse LiDAR and camera configurations. Experiments on the R3LIVE dataset show that the proposed method achieves a mean error of 4.89° / 1.63 m, outperforming existing methods, while completing a single registration in approximately 0.68 s.
Jul 1, 2026

Reliability-Aware CT-MRI Registration: A Quality Engineering Framework with Stability Analysis and Risk Classification

Multimodal CT-MRI registration is central to image-guided radiotherapy, surgical navigation, and diagnostic workflows, but most pipelines report only aggregate quality metrics without per-case reliability signals. We propose a reliability-aware framework that converts registration quality into Green/Yellow/Red risk categories using data-learned thresholds. CT images were registered to T1-weighted MRI using rigid and affine transformations on 90 paired slices from 18 patients across brain, abdominal, and neck anatomies. Reliability was assessed using Delta NMI, Delta SSIM, Dice overlap, registration stability, and inverse consistency error, combined into a single score R. Thresholds learned from training patients were applied unchanged to held-out test patients. Affine registration outperformed rigid registration on NMI and SSIM, yielding 44% Green classifications versus 33% for rigid. Reliability-filtered registrations improved the average alignment profile compared with unfiltered methods. Per-anatomy analysis showed substantial variation, with stronger reliability for abdominal registrations than brain registrations. Weight sensitivity analysis identified Dice overlap as the dominant reliability component. The proposed framework provides an interpretable quality-control layer for multimodal registration, while risk thresholds reflect statistical rather than clinical validation.
Jun 29, 2026

RBE-Flow: Recurrent Bayesian Estimation on Feature Manifolds for Cross-Modal Registration

Cross-modal image registration is essential for multi-sensor perception but remains fundamentally challenging due to severe non-linear radiometric discrepancies and geometric distortions. Existing deterministic matching methods lack uncertainty awareness, struggling to navigate the resulting highly non-convex optimization landscape and frequently accumulating errors in ambiguous regions. In this paper, we propose RBE-Flow, a novel framework that reformulates dense cross-modal flow estimation as a closed-loop recurrent Bayesian estimation problem on learned feature manifolds. Diverging from standard feed-forward regression, RBE-Flow establishes a robust self-correcting mechanism by deeply coupling feature-metric non-linear optimization with probabilistic state updates. Specifically, a Recurrent Manifold Optimization (RMO) block iteratively generates flow observations and their associated uncertainties, which are then optimally assimilated into the prior state via an Uncertainty-Adaptive Probabilistic Update (UAPU) using deterministic sigma-point projection. Crucially, the resulting calibrated posterior covariance is fed back to adaptively regularize the damping of subsequent optimization steps, allowing the system to modulate its convergence based on predictive confidence. To ensure stable probabilistic training, we introduce a hybrid supervision scheme featuring a geometry-aware rectified NLL loss that structurally prevents variance collapse. Extensive experiments on challenging OSdataset, WHU-OPT-SAR, and RoadScene benchmarks demonstrate that RBE-Flow consistently achieves state-of-the-art performance, outperforming existing methods by a significant margin, particularly under strict sub-pixel criteria. Project page: https://github.com/NEU-Liuxuecong/RBE-Flow
Jun 27, 2026

Projection-based coupling of infrared thermography and stereocorrelation-based digital image correlation

Full-field measurement techniques such as digital image correlation and infrared thermography are prevalent in experimental solid mechanics. Digital image correlation is used to analyze surface deformation, while infrared thermography quantifies surface temperature fields. However, sophisticated procedures are necessary to express both datasets in the same Lagrangian frame, especially when analyzing non-flat surfaces. In this study, we propose an external projection-based coupling that uses the pinhole camera model to relate two-dimensional temperature data measured by infrared thermography to three-dimensional point coordinates from stereocorrelation-based digital image correlation. Unlike existing multiview approaches, we utilize two independently calibrated industrial-grade systems and augment the experimental evaluation with the pinhole camera model. The projection matrix of the camera model is calibrated using a single image of a reference object. Through this projection, temperature fields are accurately represented at material points. Our method is particularly suited for, but not restricted to, curved surfaces and is straightforward to embed in existing experimental protocols, as the image registration is kept as is. Additionally, we use radial basis functions as a global interpolation ansatz in both space and time to compute in-plane temperature gradients and even temperature rates on curved surfaces, thereby providing an extensive and information-rich full-field dataset.
Jun 25, 2026

LayersReg: A Layer-by-Layer Progressive Regressor for Reliable Intraoperative 3D/2D Registration

3D/2D registration serves as a cornerstone technique in surgical navigation. Traditional iterative optimization algorithms suffer from low efficiency and high failure rates in intraoperative settings. Deep learning-based methods reformulate registration from iterative optimization to a regression problem that maps image appearance features to spatial pose, typically achieving improved real-time performance and accuracy. However, such learnable methods are confined to memory-driven retrieval of specific pose features rather than understanding the task of image alignment itself, which limits their generalization in complex scenarios. We propose LayersReg, a pioneering regression paradigm that endows the model with 3D anatomical awareness and searches for the correct pose in a progressive, layer-by-layer manner. Inspired by the iterative pose-searching optimization criterion of classical registration, LayersReg searches for correlations between the moving and fixed images in feature space, capturing the trend of pixel flow and thereby converging iteratively toward the correct spatial pose transformation. We further design a coupling of node-wise regression with the progressive registration framework to enhance the model's perception of spatial pose changes. Experimental results demonstrate that under large offsets and multimodality conditions, LayersReg achieves high accuracy on both X-ray/CT registration (0.68°, 1.41 mm) and slice localization (0.73°, 1.55 mm) tasks, outperforming existing state-of-the-art methods while meeting the intraoperative demands for precision and real-time capability.
Jun 2, 2026

Cross-Modality Feature Fusion Based on Structured State Space Duality for Multimodal Image Registration Network

In multi-modal image registration, the primary challenge lies in shared structural information extraction. Compared to Transformers, Structured State Space Duality (SSD) offers greater global structural feature extraction with higher efficiency during training and inference. Inspired by these advantages, we propose a novel algorithm for multi-modal image registration, named RegNetMamba-2. Our algorithm incorporates SSD into coarse-to-fine matching process to extract local and global structural features effectively. Firstly, SSD is applied in three different scales for multi-modal feature extraction in our network. To strengthen local representation, we pay more attention on foreground edge and structural information by feature scaling function of SSD. Secondly, for shared feature extraction of input images and multi-modal feature fusion in all scales, we propose cross-modality feature fusion model based on SSD, consisting of Cross-Modality feature Interaction (CMI) module and Multi-Scale feature Fusion (MSF) module. CMI module is designed for cross-modality feature extraction of each scale by SSD in cross form. MSF module is designed to employ a progressive upward fusion in feature-level to obtain fine features, consisting of multi-modal features in all scales. Following coarse-to-fine, the features in 1/8 scale from CMI and 1/2 scale from MSF are collected to calculate matching probability scores. Then we respectively establish matching process by correspondences of pixel-wise. Extensive experiments demonstrate that comparing with state-of-the-art deep-learning based algorithms, RegNetMamba-2 has achieved good effects in both performance and efficiency for multi-modal image registration on the following datasets: VIS-SAR (OSDataset), VIS-IR (LGHD/RoadSence) and VIS-NIR (RGB-NIR sense).
May 13, 2026

VoxCor: Training-Free Volumetric Features for Multimodal Voxel Correspondence

Cross-modal 3D medical image analysis requires voxelwise representations that remain anatomically consistent across imaging contrasts, scanners, and acquisition protocols. Recent work has shown that frozen 2D Vision Transformer (ViT) foundation models can support such representations, but typical pipelines extract features along a single anatomical axis and adapt those features inside a registration solver for one image pair at a time, leaving complementary viewing directions unused and producing representations that do not transfer to new volumes. We introduce VoxCor, a training-free fit--transform method for reusable volumetric feature representations from frozen 2D ViT foundation models. During an offline fitting phase, VoxCor combines triplanar ViT inference with a compact closed-form weighted partial least squares (WPLS) projection that uses fitting-time voxel correspondences to select modality-stable anatomical directions in the triplanar feature space. At transform time, new volumes are mapped by triplanar ViT inference and linear projection alone, without fine-tuning or registration. Voxel correspondences can then be queried directly by nearest-neighbor search. We evaluate VoxCor on intra-subject Abdomen MR--CT and inter-subject HCP T2w--T1w tasks using deformable registration, voxelwise k-nearest-neighbor segmentation, and segmentation-center landmark localization. VoxCor improves the hardest cross-subject, cross-modality transfer settings, reduces encoder sensitivity for dense correspondence transfer, and yields registration performance competitive with handcrafted descriptors and learned 3D features. This positions VoxCor as a reusable feature layer for downstream multimodal analysis beyond pairwise registration. Code, configuration files, and implementation details are publicly available on GitHub at guneytombak/VoxCor.
May 13, 2026

Uncertainty-aware Spatial-Frequency Registration and Fusion for Infrared and Visible Images

Infrared and Visible Image Fusion (IVIF) has shown promise in visual tasks under challenging environments, but fusion under unregistered conditions faces inherent misalignments. Current studies to solve them either predict the deformation parameters coarse-to-fine (i.e., coarse registration and fine registration) or estimate the deformation fields in multi-scales for registration. Though straightforward, they overlook the cumulative errors in registration, which contaminate the fusion stage and severely deteriorate the resulting images. We introduce the Spatial-Frequency Registration and Fusion (SFRF) framework, which incorporates uncertainty estimation and infrared thermal radiation distribution consistency into a unified pipeline to handle the error accumulation for robust registration and fusion across both spatial and frequency domains. Specifically, SFRF constructs a Multi-scale Iterative Registration (MIR) framework that iteratively refines the deformation field across scales, leveraging uncertainty estimation at each stage to mitigate error accumulation and enhance alignment accuracy dynamically. To ensure the accurate alignment of infrared thermal distributions during registration, thermal radiation distribution consistency is employed as a frequency-domain supervisory signal, promoting global consistency in the frequency domain. Based on the spatial-frequency alignment, SFRF further adopts a Dual-branch Spatial-Frequency Fusion (DSFF) module, which incorporates spatial geometric features and frequency distribution information to reconstruct visually appealing images. SFRF achieves impressive performance across diverse datasets.
May 12, 2026

TAR: Text Semantic Assisted Cross-modal Image Registration Framework for Optical and SAR Images

Existing deep learning-based methods can capture shared features from optical and synthetic aperture radar (SAR) images for spatial alignment. However, optical-SAR registration remains challenging under large geometric deformations, because the model needs to simultaneously handle cross-modal appearance discrepancies and complex spatial transformations. To address this issue, this paper proposes a text semantic-assisted cross-modal image registration framework, named TAR, for optical and SAR images. TAR exploits text semantic priors from remote sensing scenes and land-cover categories to alleviate the modality gap and enhance cross-modal feature learning. TAR consists of three components: a multi-scale visual feature learning (MSFL) module, a text-assisted feature enhancement (TAFE) module, and a coarse-to-fine dense matching (CFDM) module. MSFL extracts multi-scale visual features from optical and SAR images. TAFE constructs text descriptors related to remote sensing scenes and land-cover objects, and uses a frozen RemoteCLIP text encoder to extract text features. These text features are introduced through visual-text interaction to enhance high-level visual features for more reliable coarse matching. CFDM then establishes coarse correspondences based on the enhanced high-level features and refines the matched locations using low-level features. Experimental results on cross-modal remote sensing images demonstrate the effectiveness of TAR, which achieves stronger matching performance than several state-of-the-art methods and yields significant gains under large geometric deformations.
May 8, 2026

FS-I2P:A Hierarchical Focus-Sweep Registration Network with Dynamically Allocated Depth

Image-to-point cloud registration is often challenged by viewpoint changes, cross-modal discrepancies, and repetitive textures, which induce scale ambiguity and consequently lead to erroneous correspondences. Recent detection-free methods alleviate this issue by leveraging multi-scale features and transformer-based interactions. However, they still suffer from attention drift across layers and intra-scale inconsistencies, hindering precise registration. Inspired by human behavior, we propose a ``Focus--Sweep'' paradigm and develop a Hierarchical Focus--Sweep Interaction Module within an SSM-based framework to enhance multi-level cross-modal feature association. In addition, we introduce a Dynamic Layer Allocation Strategy that adaptively determines the iteration depth to better exploit geometric constraints and improve matching robustness. Extensive experiments and ablations on two benchmarks, RGB-D Scenes V2 and 7-Scenes, demonstrate that our approach achieves state-of-the-art performance.
May 6, 2026

Angle-I2P: Angle-Consistent-Aware Hierarchical Attention for Cross-Modality Outlier Rejection

Image-to-point-cloud registration (I2P) is a fundamental task in robotic applications such as manipulation,grasping, and localization. Existing deep learning-based I2P methods seek to align image and point cloud features in a learned representation space to establish correspondences, and have achieved promising results. However, when the inlier ratio of the initial matching pairs is low, conventional Perspective-n-Points (PnP) methods may struggle to achieve accurate results. To address this limitation, we propose Angle-I2P, an outlier rejection network that leverages angle-consistent geometric constraints and hierarchical attention. First, we design a scale-invariant, crossmodality geometric constraint based on angular consistency. This explicit geometric constraint guides the model in distinguishing inliers from outliers. Furthermore, we propose a global-tolocal hierarchical attention mechanism that effectively filters out geometrically inconsistent matches under rigid transformation, thereby improving the Inlier Ratio (IR) and Registration Recall (RR). Experimental results demonstrate that our method achieves state-of-the-art performance on the 7Scenes, RGBD Scenes V2, and a self-collected dataset, with consistent improvements across all benchmarks.
Apr 11, 2026

Warm-Started Reinforcement Learning for Iterative 3D/2D Liver Registration

Registration between preoperative CT and intraoperative laparoscopic video plays a crucial role in augmented reality (AR) guidance for minimally invasive surgery. Learning-based methods have recently achieved registration errors comparable to optimization-based approaches while offering faster inference. However, many supervised methods produce coarse alignments that rely on additional optimization-based refinement, thereby increasing inference time. We present a discrete-action reinforcement learning (RL) framework that formulates CT-to-video registration as a sequential decision-making process. A shared feature encoder, warm-started from a supervised pose estimation network to provide stable geometric features and faster convergence, extracts representations from CT renderings and laparoscopic frames, while an RL policy head learns to choose rigid transformations along six degrees of freedom and to decide when to stop the iteration. Experiments on a public laparoscopic dataset demonstrated that our method achieved an average target registration error (TRE) of 15.70 mm, comparable to supervised approaches with optimization, while achieving faster convergence. The proposed RL-based formulation enables automated, efficient iterative registration without manually tuned step sizes or stopping criteria. This discrete framework provides a practical foundation for future continuous-action and deformable registration models in surgical AR applications.
Apr 11, 2026

Are Pretrained Image Matchers Good Enough for SAR-Optical Satellite Registration?

Cross-modal optical--SAR (Synthetic Aperture Radar) registration is a bottleneck in remote-sensing disaster response. Modern image matchers are developed and benchmarked almost exclusively on natural-image domains. We evaluate twenty-four pretrained matcher configurations in a zero-shot setting, with no fine-tuning or domain adaptation on satellite or SAR data. The evaluation spans SpaceNet9 and two additional cross-modal benchmarks under a deterministic protocol that uses tiled large-image inference, robust geometric filtering, and tie-point-grounded metrics. Our results show uneven transfer: matchers with explicit cross-modal training do not uniformly outperform those without it. XoFTR (trained for visible--thermal matching) and RoMa achieve the lowest reported mean tie-point error at 3.03.0 px on the labeled SpaceNet9 training scenes. RoMa achieves this result without any cross-modal training. MatchAnything-ELoFTR (3.43.4 px), trained on synthetic cross-modal pairs, is close behind. XoFTR also runs roughly an order of magnitude faster than the RoMa family (0.40.4 s vs. 5.05.0 s per pair). RoMa's performance is consistent with the hypothesis that frozen DINOv2 features confer robustness to large appearance shifts. Deployment protocol choices (geometry model, tile size, inlier gating) change mean error by up to 33×33\times for a single matcher. This shift can exceed the effect of swapping matchers within our evaluated protocol ablations. Affine geometry alone reduces mean error from 12.312.3 to 9.79.7 px.
Apr 11, 2026

Particle Diffusion Matching: Random Walk Correspondence Search for the Alignment of Standard and Ultra-Widefield Fundus Images

We propose a robust alignment technique for Standard Fundus Images (SFIs) and Ultra-Widefield Fundus Images (UWFIs), which are challenging to align due to differences in scale, appearance, and the scarcity of distinctive features. Our method, termed Particle Diffusion Matching (PDM), performs alignment through an iterative Random Walk Correspondence Search (RWCS) guided by a diffusion model. At each iteration, the model estimates displacement vectors for particle points by considering local appearance, the structural distribution of particles, and an estimated global transformation, enabling progressive refinement of correspondences even under difficult conditions. PDM achieves state-of-the-art performance across multiple retinal image alignment benchmarks, showing substantial improvement on a primary dataset of SFI-UWFI pairs and demonstrating its effectiveness in real-world clinical scenarios. By providing accurate and scalable correspondence estimation, PDM overcomes the limitations of existing methods and facilitates the integration of complementary retinal image modalities. This diffusion-guided search strategy offers a new direction for improving downstream supervised learning, disease diagnosis, and multi-modal image analysis in ophthalmology.
Apr 11, 2026

Active Diffusion Matching: Score-based Iterative Alignment of Cross-Modal Retinal Images

Objective: The study aims to address the challenge of aligning Standard Fundus Images (SFIs) and Ultra-Widefield Fundus Images (UWFIs), which is difficult due to their substantial differences in viewing range and the amorphous appearance of the retina. Currently, no specialized method exists for this task, and existing image alignment techniques lack accuracy. Methods: We propose Active Diffusion Matching (ADM), a novel cross-modal alignment method. ADM integrates two interdependent score-based diffusion models to jointly estimate global transformations and local deformations via an iterative Langevin Markov chain. This approach facilitates a stochastic, progressive search for optimal alignment. Additionally, custom sampling strategies are introduced to enhance the adaptability of ADM to given input image pairs. Results: Comparative experimental evaluations demonstrate that ADM achieves state-of-the-art alignment accuracy. This was validated on two datasets: a private dataset of SFI-UWFI pairs and a public dataset of SFI-SFI pairs, with mAUC improvements of 5.2 and 0.4 points on the private and public datasets, respectively, compared to existing state-of-the-art methods. Conclusion: ADM effectively bridges the gap in aligning SFIs and UWFIs, providing an innovative solution to a previously unaddressed challenge. The method's ability to jointly optimize global and local alignment makes it highly effective for cross-modal image alignment tasks. Significance: ADM has the potential to transform the integrated analysis of SFIs and UWFIs, enabling better clinical utility and supporting learning-based image enhancements. This advancement could significantly improve diagnostic accuracy and patient outcomes in ophthalmology.
Apr 10, 2026

Search-MIND: Training-Free Multi-Modal Medical Image Registration

Multi-modal image registration plays a critical role in precision medicine but faces challenges from non-linear intensity relationships and local optima. While deep learning models enable rapid inference, they often suffer from generalization collapse on unseen modalities. To address this, we propose Search-MIND, a training-free, iterative optimization framework for instance-specific registration. Our pipeline utilizes a coarse-to-fine strategy: a hierarchical coarse alignment stage followed by deformable refinement. We introduce two novel loss functions: Variance-Weighted Mutual Information (VWMI), which prioritizes informative tissue regions to shield global alignment from background noise and uniform regions, and Search-MIND (S-MIND), which broadens the convergence basin of structural descriptors by considering larger local search range. Evaluations on CARE Liver 2025 and CHAOS Challenge datasets show that Search-MIND consistently outperforms classical baselines like ANTs and foundation model-based approaches like DINO-reg, offering superior stability across diverse modalities.
Apr 7, 2026

Automatic dental superimposition of 3D intraorals and 2D photographs for human identification

Dental comparison is considered a primary identification method, at the level of fingerprints and DNA profiling. One crucial but time-consuming step of this method is the morphological comparison. One of the main challenges to apply this method is the lack of ante-mortem medical records, specially on scenarios such as migrant death at the border and/or in countries where there is no universal healthcare. The availability of photos on social media where teeth are visible has led many odontologists to consider morphological comparison using them. However, state-of-the-art proposals have significant limitations, including the lack of proper modeling of perspective distortion and the absence of objective approaches that quantify morphological differences. Our proposal involves a 3D (post-mortem scan) - 2D (ante-mortem photos) approach. Using computer vision and optimization techniques, we replicate the ante-mortem image with the 3D model to perform the morphological comparison. Two automatic approaches have been developed: i) using paired landmarks and ii) using a segmentation of the teeth region to estimate camera parameters. Both are capable of obtaining very promising results over 20,164 cross comparisons from 142 samples, obtaining mean ranking values of 1.6 and 1.5, respectively. These results clearly outperform filtering capabilities of automatic dental chart comparison approaches, while providing an automatic, objective and quantitative score of the morphological correspondence, easily to interpret and analyze by visualizing superimposed images.
Apr 7, 2026

CRFT: Consistent-Recurrent Feature Flow Transformer for Cross-Modal Image Registration

We present Consistent-Recurrent Feature Flow Transformer (CRFT), a unified coarse-to-fine framework based on feature flow learning for robust cross-modal image registration. CRFT learns a modality-independent feature flow representation within a transformer-based architecture that jointly performs feature alignment and flow estimation. The coarse stage establishes global correspondences through multi-scale feature correlation, while the fine stage refines local details via hierarchical feature fusion and adaptive spatial reasoning. To enhance geometric adaptability, an iterative discrepancy-guided attention mechanism with a Spatial Geometric Transform (SGT) recurrently refines the flow field, progressively capturing subtle spatial inconsistencies and enforcing feature-level consistency. This design enables accurate alignment under large affine and scale variations while maintaining structural coherence across modalities. Extensive experiments on diverse cross-modal datasets demonstrate that CRFT consistently outperforms state-of-the-art registration methods in both accuracy and robustness. Beyond registration, CRFT provides a generalizable paradigm for multimodal spatial correspondence, offering broad applicability to remote sensing, autonomous navigation, and medical imaging. Code and datasets are publicly available at https://github.com/NEU-Liuxuecong/CRFT.
Apr 3, 2026

SCC-Loc: A Unified Semantic Cascade Consensus Framework for UAV Thermal Geo-Localization

Cross-modal Thermal Geo-localization (TG) provides a robust, all-weather solution for Unmanned Aerial Vehicles (UAVs) in Global Navigation Satellite System (GNSS)-denied environments. However, profound thermal-visible modality gaps introduce severe feature ambiguity, systematically corrupting conventional coarse-to-fine registration. To dismantle this bottleneck, we propose SCC-Loc, a unified Semantic-Cascade-Consensus localization framework. By sharing a single DINOv2 backbone across global retrieval and MINIMARoMa_{\text{RoMa}} matching, it minimizes memory footprint and achieves zero-shot, highly accurate absolute position estimation. Specifically, we tackle modality ambiguity by introducing three cohesive components. First, we design the Semantic-Guided Viewport Alignment (SGVA) module to adaptively optimize satellite crop regions, effectively correcting initial spatial deviations. Second, we develop the Cascaded Spatial-Adaptive Texture-Structure Filtering (C-SATSF) mechanism to explicitly enforce geometric consistency, thereby eradicating dense cross-modal outliers. Finally, we propose the Consensus-Driven Reliability-Aware Position Selection (CD-RAPS) strategy to derive the optimal solution through a synergy of physically constrained pose optimization. To address data scarcity, we construct Thermal-UAV, a comprehensive dataset providing 11,890 diverse thermal queries referenced against a large-scale satellite ortho-photo and corresponding spatially aligned Digital Surface Model (DSM). Extensive experiments demonstrate that SCC-Loc establishes a new state-of-the-art, suppressing the mean localization error to 9.37 m and providing a 7.6-fold accuracy improvement within a strict 5-m threshold over the strongest baseline. Code and dataset are available at https://github.com/FloralHercules/SCC-Loc.
Mar 30, 2026

Hg-I2P: Bridging Modalities for Generalizable Image-to-Point-Cloud Registration via Heterogeneous Graphs

Image-to-point-cloud (I2P) registration aims to align 2D images with 3D point clouds by establishing reliable 2D-3D correspondences. The drastic modality gap between images and point clouds makes it challenging to learn features that are both discriminative and generalizable, leading to severe performance drops in unseen scenarios. We address this challenge by introducing a heterogeneous graph that enables refining both cross-modal features and correspondences within a unified architecture. The proposed graph represents a mapping between segmented 2D and 3D regions, which enhances cross-modal feature interaction and thus improves feature discriminability. In addition, modeling the consistency among vertices and edges within the graph enables pruning of unreliable correspondences. Building on these insights, we propose a heterogeneous graph embedded I2P registration method, termed Hg-I2P. It learns a heterogeneous graph by mining multi-path feature relationships, adapts features under the guidance of heterogeneous edges, and prunes correspondences using graph-based projection consistency. Experiments on six indoor and outdoor benchmarks under cross-domain setups demonstrate that Hg-I2P significantly outperforms existing methods in both generalization and accuracy. Code is released on https://github.com/anpei96/hg-i2p-demo.
Mar 27, 2026

Adapting Frozen Mono-modal Backbones for Multi-modal Registration via Contrast-Agnostic Instance Optimization

Deformable image registration remains a central challenge in medical image analysis, particularly under multi-modal scenarios where intensity distributions vary significantly across scans. While deep learning methods provide efficient feed-forward predictions, they often fail to generalize robustly under distribution shifts at test time. A straightforward remedy is full network fine-tuning, yet for modern architectures such as Transformers or deep U-Nets, this adaptation is prohibitively expensive in both memory and runtime when operating in 3D. Meanwhile, the naive fine-tuning struggles more with potential degradation in performance in the existence of drastic domain shifts. In this work, we propose a registration framework that integrates a frozen pretrained mono-modal registration model with a lightweight adaptation pipeline for multi-modal image registration. Specifically, we employ style transfer based on contrast-agnostic representation generation and refinement modules to bridge modality and domain gaps with instance optimization at test time. This design is orthogonal to the choice of backbone mono-modal model, thus avoids the computational burden of full fine-tuning while retaining the flexibility to adapt to unseen domains. We evaluate our approach on the Learn2Reg 2025 LUMIR validation set and observe consistent improvements over the pretrained state-of-the-art mono-modal backbone. In particular, the method ranks second on the multi-modal subset, third on the out-of-domain subset, and achieves fourth place overall in Dice score. These results demonstrate that combining frozen mono-modal models with modality adaptation and lightweight instance optimization offers an effective and practical pathway toward robust multi-modal registration.
Mar 27, 2026

GLASS: Geometry-aware Local Alignment and Structure Synchronization Network for 2D-3D Registration

Image-to-point cloud registration methods typically follow a coarse-to-fine pipeline, extracting patch-level correspondences and refining them into dense pixel-to-point matches. However, in scenes with repetitive patterns, images often lack sufficient 3D structural cues and alignment with point clouds, leading to incorrect matches. Moreover, prior methods usually overlook structural consistency, limiting the full exploitation of correspondences. To address these issues, we propose two novel modules: the Local Geometry Enhancement (LGE) module and the Graph Distribution Consistency (GDC) module. LGE enhances both image and point cloud features with normal vectors, injecting geometric structure into image features to reduce mismatches. GDC constructs a graph from matched points to update features and explicitly constrain similarity distributions. Extensive experiments and ablations on two benchmarks, RGB-D Scenes v2 and 7-Scenes, demonstrate that our approach achieves state-of-the-art performance in image-to-point cloud registration.
Mar 20, 2026

Disentangle-then-Align: Non-Iterative Hybrid Multimodal Image Registration via Cross-Scale Feature Disentanglement

Multimodal image registration is a fundamental task and a prerequisite for downstream cross-modal analysis. Despite recent progress in shared feature extraction and multi-scale architectures, two key limitations remain. First, some methods use disentanglement to learn shared features but mainly regularize the shared part, allowing modality-private cues to leak into the shared space. Second, most multi-scale frameworks support only a single transformation type, limiting their applicability when global misalignment and local deformation coexist. To address these issues, we formulate hybrid multimodal registration as jointly learning a stable shared feature space and a unified hybrid transformation. Based on this view, we propose HRNet, a Hybrid Registration Network that couples representation disentanglement with hybrid parameter prediction. A shared backbone with Modality-Specific Batch Normalization (MSBN) extracts multi-scale features, while a Cross-scale Disentanglement and Adaptive Projection (CDAP) module suppresses modality-private cues and projects shared features into a stable subspace for matching. Built on this shared space, a Hybrid Parameter Prediction Module (HPPM) performs non-iterative coarse-to-fine estimation of global rigid parameters and deformation fields, which are fused into a coherent deformation field. Extensive experiments on four multimodal datasets demonstrate state-of-the-art performance on rigid and non-rigid registration tasks. The code is available at the project website.
Mar 18, 2026

SegFly: A Dataset and 2D-3D-2D Paradigm for Aerial RGB-Thermal Semantic Segmentation at Scale

Semantic segmentation for uncrewed aerial vehicles (UAVs) is fundamental for aerial scene understanding, yet existing RGB and RGB-T datasets remain limited in scale, diversity, and annotation efficiency due to the high cost of manual labeling and the difficulties of accurate RGB-T alignment on off-the-shelf UAVs. To address these challenges, we propose a scalable geometry-driven 2D-3D-2D paradigm that leverages multi-view redundancy in high-overlap aerial imagery to automatically propagate labels from a small subset of manually annotated RGB images to both RGB and thermal modalities within a unified framework. By lifting less than 3% of RGB images into a semantic 3D point cloud and rendering it into all views, our approach enables dense pseudo ground-truth generation across large image collections, automatically producing 97% of RGB labels and 100% of thermal labels while achieving 91% and 88% annotation accuracy without any 2D manual refinement. We further extend this 2D-3D-2D paradigm to cross-modal image registration, using 3D geometry as an intermediate alignment space to obtain fully automatic, strong pixel-level RGB-T alignment with 87% registration accuracy and no hardware-level synchronization. Applying our framework to existing geo-referenced aerial imagery, we construct SegFly, a large-scale benchmark with over 20,000 high-resolution RGB images and more than 15,000 geometrically aligned RGB-T pairs spanning diverse urban, industrial, and rural environments across multiple altitudes and seasons. On SegFly, we establish the Firefly baseline for RGB and thermal semantic segmentation and show that both conventional architectures and vision foundation models benefit substantially from SegFly supervision, highlighting the potential of geometry-driven 2D-3D-2D pipelines for scalable multi-modal aerial scene understanding. Data and Code available at https://github.com/markus-42/SegFly.
Mar 14, 2026

Effective Feature Learning for 3D Medical Registration via Domain-Specialized DINO Pretraining

Medical image registration is a critical component of clinical imaging workflows, enabling accurate longitudinal assessment, multi-modal data fusion, and image-guided interventions. Intensity-based approaches often struggle with interscanner variability and complex anatomical deformations, whereas feature-based methods offer improved robustness by leveraging semantically informed representations. In this work, we investigate DINO-style self-supervised pretraining directly on 3D medical imaging data, aiming to learn dense volumetric features well suited for deformable registration. We assess the resulting representations on challenging interpatient abdominal registration task across both MRI and CT modalities. Our domain-specialized pretraining outperforms the DINOv2 model trained on a large-scale collection of natural images, while requiring substantially lower computational resources at inference time. Moreover, it surpasses established registration models under out-of-domain evaluation, demonstrating the value of task-agnostic yet medical imaging-focused pretraining for robust and efficient 3D image registration.