Cross-Modal Representation Learning

Mixture-of-Experts (MoE) presents a naturally compatible and scalable framework for multimodal learning, demonstrating strong adaptability across diverse modalities and tasks. Despite its growing success, a comprehensive and systematic review on the MoE metho addressing multimodal challenges remains lacking. Existing surveys tend to evaluate either multimodal learning or MoE independently from method taxonomy, overlooking the unique interplay between them. This survey fills that gap by answering a central question: \textit{How does MoE effectively resolve multimodal challenges?} We approach this from three key perspectives: (1) \textbf{MoE as an Efficient Multimodal Engine:} enabling scalable multimodal modeling by decoupling computational cost from parameter growth and mitigating modality redundancy through selective expert activation; (2) \textbf{MoE as a Multimodal Representation Learner:} integrating complementary multi-opinion expert knowledge to enrich alignment and interaction representations; and (3) \textbf{MoE as a Multimodal Adapter:} providing a modular and flexible mechanism to model imperfect data scenarios such as modality imbalance and missing modality. Through our extensive literature review, we identify critical research gaps, including interpretable routing, expert communication, modality integration, and lifelong multimodal learning. We position this survey as a foundation for future research toward interpretable and sustainable multimodal Mixture-of-Experts system.

Multi-source remote sensing enables complementary observation of ground objects, while cross-modal fine-grained object retrieval remains challenging, especially under unaligned optical and SAR conditions. Unlike conventional retrieval settings that rely on paired or spatially aligned samples, practical optical-SAR retrieval is affected by substantial modality discrepancy, speckle noise, and structural inconsistency, which limit robust cross-modal representation learning. To address this problem, we propose GeoMamba, a geometry-driven framework tailored for optical-SAR fine-grained retrieval. Specifically, GeoMamba introduces a Geometric Feature Injection (GFI) module that enhances cross-modal feature interaction and incorporates structural priors, thereby improving the robustness of SAR representations and promoting geometry-consistent feature learning. In addition, a Geometric Consistency Constraint (GCC) module, together with a Deep Supervision (DS) strategy, imposes hierarchical geometric constraints using classical operators, which helps preserve informative object structures during representation learning. We further construct a new dataset, FGOS-as, containing 11 aerospace and maritime categories for evaluating unaligned cross-modal fine-grained object retrieval in realistic remote sensing scenarios. Extensive experiments on FGOS-as demonstrate that GeoMamba outperforms existing methods, achieving 63.3% mAP and 77.0% Rank-1 accuracy in all-to-all retrieval setting.

Decoding visual information from electroencephalography (EEG) signals remains a fundamental challenge in brain-computer interfaces and medical rehabilitation. Existing EEG visual decoding methods mainly focus on learning a single global EEG embedding for cross-modal alignment, but they largely overlook the staged and hierarchical characteristics of human visual processing. To address this limitation, we propose a neuroscience-inspired staged representation learning framework that reformulates EEG visual decoding as a stage-specific representation decomposition problem. The proposed framework organizes EEG representation learning into three complementary phases: low-level visual representation learning, high-level semantic representation learning, and integrative information fusion. To strengthen semantic modeling, we further introduce a multimodal dual-level semantic learning mechanism that separates coarse label-level semantics from fine image-level visual-semantic information. In addition, semantic latent channels are introduced as computational representation channels generated from observed visual EEG signals, expanding the channel-level semantic representation space for structured semantic abstraction and cross-modal alignment. Extensive experiments on the THINGS-EEG benchmark demonstrate that the proposed method achieves superior performance under subject-dependent zero-shot evaluation and improved exact retrieval under subject-independent zero-shot evaluation. Additional analyses, including layer-wise retrieval, temporal accumulation, expanded multi-image retrieval, and ablation studies, further support the effectiveness of staged decomposition and structured semantic modeling. These results suggest that explicitly modeling staged perceptual, semantic, and integrative representations provides an effective neuroscience-inspired framework for EEG-based visual decoding.

Cross-modality recognition has many important applications in science, law enforcement and entertainment. Popular methods to bridge the modality gap include reducing the distributional differences of representations of different modalities, learning indistinguishable representations or explicit modality transfer. The first two approaches suffer from the loss of discriminant information while removing the modality-specific variations. The third one heavily relies on the successful modality transfer, could face catastrophic performance drop when explicit modality transfers are not possible or difficult. To tackle this problem, we proposed a compact encoder-decoder neural module (cmUNet) to learn modality-agnostic representations while retaining identity-related information. This is achieved through cross-modality transformation and in-modality reconstruction, enhanced by an adversarial/perceptual loss which encourages indistinguishability of representations in the original sample space. For cross-modality matching, we propose MarrNet where cmUNet is connected to a standard feature extraction network which takes as inputs the modality-agnostic representations and outputs similarity scores for matching. We validated our method on five challenging tasks, namely Raman-infrared spectrum matching, cross-modality person re-identification and heterogeneous (photo-sketch, visible-near infrared and visible-thermal) face recognition, where MarrNet showed superior performance compared to state-of-the-art methods. Furthermore, it is observed that a cross-modality matching method could be biased to extract discriminant information from partial or even wrong regions, due to incompetence of dealing with modality gaps, which subsequently leads to poor generalization. We show that robustness to occlusions can be an indicator of whether a method can well bridge the modality gap.

Multimodal pre-training demonstrates strong generalization performance, but this paradigm is often impractical in domains where paired data are scarce. A promising alternative is post-hoc multimodal alignment, which aligns separately pre-trained unimodal encoders using a limited number of paired examples. However, existing methods focus primarily on aligning global representations, missing patch-token relations. This may hinder transfer to tasks that require fine-grained cross-modal matching beyond coarse sample-level semantics. To address this issue, we propose a post-hoc alignment method that learns token-level cross-modal structure using relative representations. Specifically, we represent images and texts through their token-level similarities to a set of learnable anchors in each modality space, which are trained to induce consistent cross-modal similarity patterns for matched pairs. Despite learning only the anchors without heavy projection layers, our approach consistently outperforms existing methods in zero-shot classification, cross-modal retrieval, and zero-shot segmentation by a substantial margin. This highlights the importance of modeling fine-grained cross-modal structure for effective post-hoc multimodal alignment with limited paired data.

Recent advances in molecular representation integrates molecular topological and visual modalities, opening new avenues for precise Molecular Relational Learning (MRL). Existing MRL methods focus on intra-domain modeling, and their inherent domain-closed effect limits applicability to molecular science, particularly in elucidating cross-domain interaction mechanisms. Consequently, the imperative for Cross-Domain Molecular Relational Learning has become increasingly pressing. Benefiting from structure-activity analysis, we propose the Domain Adversarial Training Network with Structural-Semantic Transfer Discrepancy (DisTrans) to optimize cross-domain adaptive representation for molecular structures and visual images. 1) We employ the gradient reversal strategy based on substructure topological discrepancies between domains to learn the domain dependence of molecular structures. This strategy guides the model to adapt to the structural adjacency patterns in the target domain, generating domain-separable structural representations. 2) We apply the cross-domain representation guidance mechanism to align the functional-group semantic information between the source and target domains, learning cross-domain consistency information. The experimental results in two typical cross-domain strategies demonstrate that DisTrans outperforms 16 baseline methods, maintaining satisfactory performance even under pronounced inter-domain discrepancy.

Drug-drug interaction (DDI) prediction is a critical task in computational biomedicine, as adverse interactions between co-administered drugs can cause severe side effects and clinical risks. A key challenge is unseen-drug generalization, where interactions must be predicted for drugs not observed during training. Although multimodal DDI models exploit diverse drug-related information, their fusion mechanisms are often tied to specific prediction architectures, limiting their reuse across models. To address this, we propose AIM-DDI, an architecture-independent multimodal integration module that represents heterogeneous modality information as tokens in a shared latent space. By modeling dependencies across modality tokens through a unified fusion module, AIM-DDI enables model-agnostic integration of structural, chemical, and semantic drug signals across different DDI prediction architectures. Extensive evaluations across diverse DDI models and DrugBank-based settings show that AIM-DDI consistently improves prediction performance, with the strongest gains under the most challenging both-unseen setting where neither drug in a test pair is observed during training. These results suggest that treating multimodal integration as a reusable module, rather than a model-specific fusion component, is an effective strategy for robust unseen-drug DDI prediction.

Cross-modal 3D medical image analysis requires voxelwise representations that remain anatomically consistent across imaging contrasts, scanners, and acquisition protocols. Recent work has shown that frozen 2D Vision Transformer (ViT) foundation models can support such representations, but typical pipelines extract features along a single anatomical axis and adapt those features inside a registration solver for one image pair at a time, leaving complementary viewing directions unused and producing representations that do not transfer to new volumes. We introduce VoxCor, a training-free fit--transform method for reusable volumetric feature representations from frozen 2D ViT foundation models. During an offline fitting phase, VoxCor combines triplanar ViT inference with a compact closed-form weighted partial least squares (WPLS) projection that uses fitting-time voxel correspondences to select modality-stable anatomical directions in the triplanar feature space. At transform time, new volumes are mapped by triplanar ViT inference and linear projection alone, without fine-tuning or registration. Voxel correspondences can then be queried directly by nearest-neighbor search. We evaluate VoxCor on intra-subject Abdomen MR--CT and inter-subject HCP T2w--T1w tasks using deformable registration, voxelwise k-nearest-neighbor segmentation, and segmentation-center landmark localization. VoxCor improves the hardest cross-subject, cross-modality transfer settings, reduces encoder sensitivity for dense correspondence transfer, and yields registration performance competitive with handcrafted descriptors and learned 3D features. This positions VoxCor as a reusable feature layer for downstream multimodal analysis beyond pairwise registration. Code, configuration files, and implementation details are publicly available on GitHub at guneytombak/VoxCor.

Few-shot action recognition (FSAR) requires models to generalize to novel action categories from only a handful of annotated samples. Despite progress with vision-language models, existing approaches still suffer from semantic-temporal misalignment, where static textual prompts fail to capture decisive visual cues that appear sparsely across sequences, and from inadequate modeling of multi-scale temporal dynamics, as short-term discriminative cues and long-range dependencies are often either oversmoothed or fragmented. To address these challenges, we propose Semantic Temporal Adaptive Representation Learning (STAR), a unified framework, consisting of a semantic-alignment component and a temporal-aware component, effectively bridging the semantic and temporal gaps and transferring the sequence modeling capability of Mamba into the FSAR. The semantic alignment module introduces a Temporal Semantic Attention (TSA) mechanism, which performs frame-level cross-modal alignment with textual cues, ensuring fine-grained semantic-temporal consistency. The temporal-aware module incorporates a Semantic Temporal Prototype Refiner (STPR) that integrates semantic-guided Mamba blocks with multi-frequency temporal sampling and bidirectional state-space refinement, yielding semantically aligned prototypes with enhanced discriminative fidelity and temporal consistency. Furthermore, temporally dependent class descriptors derived from large language models (LLMs) provide long-range semantic guidance. Extensive experiments on five FSAR benchmarks demonstrate the consistent superiority of STAR over state-of-the-art methods. For instance, STAR achieves up to 8.1% and 6.7% gains on the SSv2-Full and SSv2-Small datasets under the 1-shot setting, and 7.3% on HMDB51, validating its effectiveness under limited supervision. The code is available at https://github.com/HongliLiu1/STAR-main.

Multimodal learning seeks to integrate information across diverse sensory sources, yet current approaches struggle to balance cross-modal generalizability with modality-specific structure. Continuous (implicit) methods preserve fine-grained priors but render generalization challenging, while discrete (explicit) approaches enforce shared prototypes at the expense of modality specificity. We introduce CoDAAR (Cross-modal Discrete Alignment And Reconstruction), a novel framework that resolves this long-standing trade-off by establishing semantic consensus across modality-specific codebooks through index-level alignment. This design uniquely allows CoDAAR to preserve modality-unique structures while achieving generalizable cross-modal representations within a unified discrete space. CoDAAR combines two complementary mechanisms: Discrete Temporal Alignment (DTA), which enables fine-grained temporal quantization, and Cascading Semantic Alignment (CSA), which promotes progressive cross-modal semantic agreement. Together, they establish a competition-free unified representation space. Trained with self-supervised reconstruction objectives on paired multimodal sequences, CoDAAR demonstrates robust cross-modal and cross-domain generalization. Across Cross-Modal Generalization benchmarks, including event classification, localization, video segmentation, and cross-dataset transfer, CoDAAR achieves state-of-the-art performance, establishing a new paradigm for discrete and generalizable multimodal representation learning.

Guided depth super-resolution (GDSR) reconstructs HR depth maps from LR inputs with HR RGB guidance. Existing methods either model each modality independently or rely on computationally expensive attention mechanisms with quadratic complexity, hindering the establishment of efficient and semantically interactive joint representations. In this paper, we observe that feature maps from different modalities exhibit semantic-level correlations during feature extraction. This motivates us to develop a more flexible approach enabling dense, semantically-aware deep interactions between modalities. To this end, we propose a novel GDSR framework centered around the Interactive State Space Model. Specifically, we design a cross-modal local scanning mechanism that enables fine-grained semantic interactions between RGB and depth features. Leveraging the Mamba architecture, our framework achieves global modeling with linear complexity. Furthermore, a cross-modal matching transform module is introduced to enhance interactive modeling quality by utilizing representative features from both modalities. Extensive experiments demonstrate competitive performance against state-of-the-art methods.

Federated graph learning (FGL) enables collaborative training on graph data across multiple clients. As graph data increasingly contain multimodal node attributes such as text and images, multimodal federated graph learning (MM-FGL) has become an important yet substantially harder setting. The key challenge is that clients from different modality domains may not share a common semantic space: even for the same concept, their local encoders can produce inconsistent representations before collaboration begins. This makes direct parameter coordination unreliable and further causes two downstream problems: forcing heterogeneous client representations into a naively shared semantic space may create false semantic agreement, and graph message passing may amplify residual inconsistency across neighborhoods. To address this issue, we propose \textbf{STAGE}, a protocol-first framework for MM-FGL. Instead of relying on direct parameter averaging, STAGE builds a shared semantic space that first translates heterogeneous multimodal features into comparable representations and then regulates how these representations propagate over local graph structures. In this way, STAGE not only improves cross-client semantic calibration, but also reduces the risk of inconsistency amplification during graph learning. Extensive experiments on 8 multimodal-attributed graphs across 5 graph-centric and modality-centric tasks show that STAGE consistently achieves state-of-the-art performance while reducing per-round communication payload.

Multiple instance learning (MIL) is the dominant framework for whole-slide image analysis in computational pathology, typically combining a frozen patch encoder, a projection layer, and a slide-level aggregator. While encoders and aggregators have been extensively studied, the projection layer remains a largely morphology-only bottleneck. This limits endpoints such as biomarker status and survival, which are governed by a molecular state that is not fully captured by H&E morphology. We introduce Molecularly Informed Staining Transform (MIST), a plug-in replacement for the MIL projection layer that uses paired spatial transcriptomics only during training to construct virtual molecular stains. MIST clusters gene expression profiles into cross-modal prototypes, anchors them in the frozen foundation model feature space, and uses them to reorganize H&E patch features along molecularly guided axes. It requires no transcriptomics at inference and can be inserted before standard MIL aggregators. We evaluate MIST across 23 downstream tasks and 8 MIL aggregators. MIST improves 240 of 256 configurations over the standard projection layer, with an average gain of +3.5%, observed consistently across endpoint types: +5.2% on survival prediction, +3.3% on tissue subtyping, and +2.6% on biomarker prediction. Ablations confirm that gene-derived prototypes are the primary source of the gains, while spatial, biological, and pathological analyses show that cross-modal prototype affinities capture spatially coherent molecular programs from H&E alone.

Nuclear magnetic resonance (NMR) spectroscopy provides an experimental readout of local chemical environments, but its use in molecular representation learning has been constrained by heterogeneous data and incomplete atom-level assignments. Here we construct complementary high-fidelity experimental and computational 13C NMR resources, which reveal a recurrent form of representational collapse: atoms that are equivalent in molecular topology can remain experimentally distinct in their real chemical environments, whereas explicit 3D descriptions are further limited by static conformations in dynamic regimes. To alleviate this bottleneck, we develop CLAIM (Contrastive Learning for Atom-to-molecule Inference of Molecular NMR), a framework that aligns efficient topological molecular inputs with atom-resolved NMR observables. Through hierarchical chemical priors and cross-level contrastive learning, CLAIM restores lost chemical resolution and markedly improves atom-level molecule-spectrum retrieval. CLAIM remains robust in flexible and tautomeric systems for 13C NMR prediction, improves stereoisomer discrimination without explicit 3D modelling, and transfers to broader molecular property tasks including ADMET prediction and fluorescence estimation. These results establish physically grounded spectral alignment as an effective strategy for alleviating chemical-environment collapse and for guiding experimentally grounded molecular representation learning.

Cardiovascular disease remains the leading cause of global mortality, yet scalable cardiac monitoring is hindered by the gap between diagnostic-rich ECG and ubiquitous wearable PPG. Bridging this gap requires representations that are compact, transferable across modalities and devices, and deployable without task-specific retraining. Here we introduce biosignal fingerprints: compact latent representations of cardiovascular state derived from a cross-modal foundation model, the Multi-modal Masked Autoencoder (M2AE), trained on over 3.4 million paired ECG and PPG signals. M2AE integrates modality-specific encoders with a shared bottleneck and dual decoders, jointly optimized using reconstruction and cross-modal contrastive objectives, yielding generalizable fingerprints that retain intra- and inter-modality features. Like a biometric fingerprint, these representations uniquely encode an individual's cardiovascular state in a modality-agnostic, privacy-preserving form reusable across clinical tasks without exposing raw waveform data or requiring model retraining. Across 7 downstream tasks, spanning cross-modal reconstruction, cardiovascular disease classification, hypertension detection, mortality prediction, and demographic inference, biosignal fingerprints achieve competitive or superior performance compared to leading domain-specialist foundation models in frozen settings, including an AUROC of 0.974 for five-class CVD classification and 0.877 for hypertension detection, with a maximum improvement of 27.7% in AUROC across 5 classification tasks. Critically, strong performance is maintained with only a single modality, enabling deployment in resource-constrained, single-sensor environments typical of real-world wearable monitoring, with direct implications for continuous cardiovascular monitoring across clinical and consumer health settings.

WiFi fingerprint-based indoor localization has been widely studied, but most existing approaches focus on absolute positioning and rely on dense coordinate annotations, which are costly to obtain at scale. In this paper, we study a fundamentally different problem: relative localization, where the goal is to directly estimate the displacement between two WiFi fingerprint traces without predicting their absolute positions. To reduce annotation overhead, we adopt weak supervision in the form of stepwise motion vectors obtained from inertial sensing. We propose Intersection Pathway (IP), a cross-modal learning framework that aligns fingerprint traces (f-traces) and displacement traces (d-traces) in a shared latent space. The key idea is to enforce an additive structure in the latent space, such that latent addition and subtraction correspond to physical motion composition, enabling direct relative-displacement inference. Experiments on a synthesized dataset derived from real measurements demonstrate that the proposed method learns displacement-aware WiFi representations and achieves accurate relative localization across varying displacement ranges. Furthermore, the learned model can be extended to few-shot absolute localization with sparse anchors.

In this work, we introduce GELATO (Geometry-preserving Embeddings via Locked Aligned TOwers), a novel approach to multimodal embedding models. We build on the VLM-style architecture, in which non-text encoders are adapted to produce input for a language model, which in turn generates embeddings for all varieties of input. We present the result: the jina-embeddings-v5-omni suite, a pair of models that encode text, image, audio, and video input into a single semantic embedding space. GELATO extends the two Jina Embeddings v5 Text models to support additional modality by adding encoders for images and audio. The backbone text embedding models and the added non-text modality encoders remain frozen. We only trained the connecting components, representing 0.35% of the total weights of the joint model. Training is therefore much more efficient than full-parameter retraining. Additionally, the language model remains effectively unaltered, producing exactly the same embeddings for text inputs as the Jina Embeddings v5 Text models. Our evaluations show that GELATO produces results that are competitive with the state-of-the-art, yielding nearly equal performance to larger multimodal embedding models.

Dynamic text-attributed graphs (DyTAGs) provide a powerful framework for modeling evolving systems in which node semantics and time-dependent interactions are tightly coupled. Recently, multimodal learning has emerged as a promising yet underexplored direction for enhancing DyTAG representation learning. However, existing methods typically rely on rigid modality partitions and one-shot fusion strategies, which limit their ability to capture the intrinsic and evolving dependencies between node semantics and interaction behaviors. To address these limitations, we propose \textbf{PRISM}, an iterative cross-modal posterior refinement framework for DyTAG representation learning. PRISM organizes DyTAG information into semantic and behavioral modalities, providing a more intrinsic alternative to carrier-level modality partitions. Instead of fusing the two modalities in a single step, PRISM learns a refinement trajectory that progressively transforms semantic priors into behavior-conditioned posterior states through cross-modal interaction with behavioral evidence. Extensive experiments on DTGB benchmark datasets show that PRISM achieves strong performance on temporal link prediction and destination node retrieval tasks. Further ablation studies validate the effectiveness of semantic--behavioral modeling and iterative posterior refinement.

We propose S3 (Specialization, Selection, Sparsification), a framework that rethinks multimodal learning through a structural perspective. Instead of encoding all signals into a fixed embedding, S3 decomposes multimodal inputs into semantic experts and selectively routes them for each task. Specialization forms concept-level experts in a shared latent space, Selection adapts routing for task-specific needs, and Sparsification prunes low-utility paths to yield compact, information-minimal representations. Across four MultiBench benchmarks, S3 improves accuracy and shows a consistent reverse U-shaped sparsity-performance trend, with peak performance at intermediate sparsity. These results suggest that structuring multimodal representations as selectable semantic components provides a practical and principled alternative to contrastive learning or InfoMax-driven approaches.

Although multi-modal learning has advanced point cloud completion, the theoretical mechanisms remain unclear. Recent works attribute success to the connection between modalities, yet we identify that standard hard projection severs this connection: projecting a sparse point cloud onto the image plane yields an extremely sparse support, which hinders visual prior propagation, a failure mode we term Cross-Modal Entropy Collapse. To address this practical limitation, we propose SplAttN, which replaces hard projection with Differentiable Gaussian Splatting to produce a dense, continuous image-plane representation. By reformulating projection as continuous density estimation, SplAttN avoids collapsed sparse support, facilitates gradient flow, and improves cross-modal connection learnability. Extensive experiments show that SplAttN achieves state-of-the-art performance on PCN and ShapeNet-55/34. Crucially, we utilize the real-world KITTI benchmark as a stress test for multi-modal reliance. Counter-factual evaluation reveals that while baselines degenerate into unimodal template retrievers insensitive to visual removal, SplAttN maintains a robust dependency on visual cues, validating that our method establishes an effective cross-modal connection. Code is available at https://github.com/zay002/SplAttN.

Biosignals acquired from different locations on the body often provide temporally ordered views of the same underlying physiological process. However, most existing self supervised learning methods treat these signals as interchangeable views, overlooking the directional temporal dynamics that link them. A canonical example is the relationship between electrocardiography (ECG), which captures the electrical activation initiating each heartbeat, and photoplethysmography (PPG), which records the resulting peripheral pulse delayed by vascular dynamics. To capture this structured relationship, we introduce xMAE, a biosignal pretraining framework that leverages masked cross modal reconstruction across temporally ordered biosignals as a training time constraint to encourage physiologically meaningful timing structure in the learned representations. We show that pretraining with xMAE yields representations that outperform both unimodal and multimodal baselines on 15 of 19 downstream tasks, including cardiovascular outcome prediction, abnormal laboratory test detection, sleep staging, and demographic inference, while generalizing across devices, body locations, and acquisition settings. Further analysis suggests that the ECG PPG timing structure is reflected in the learned PPG representations. More broadly, xMAE demonstrates the effectiveness of incorporating temporal structure into multimodal pretraining when signals observe different stages of a shared underlying process. Code is available at https://github.com/hzhou3/xMAE.

Continuous Glucose Monitoring (CGM) can detect early metabolic subphenotypes (insulin resistance, IR; $β$-cell dysfunction), but population-scale deployment faces two coupled problems. First, the same physiological state appears through multiple views (CGM time series, venous OGTT, Glucodensity summaries), so single-view representations fail to transfer when deployment shifts the modality or setting. Second, baselines perform inconsistently across these shifts. Both problems point to one remedy: representations that abstract away from any single view to capture higher-level temporal and distributional structure. We propose CGM-JEPA, a self-supervised pretraining framework which predicts masked latent representations rather than raw values, yielding abstraction that transfers across modalities. X-CGM-JEPA adds a masked Glucodensity cross-view objective for complementary distributional information. We pretrain on $\sim$389k unlabeled CGM readings from 228 subjects and evaluate on two clinical cohorts ($N=27$ and $N=17$ public-release subsets) across three regimes (cohort generalization, venous-to-CGM transfer, home CGM) under 20-iteration $\times$ 2-fold cross-validation. X-CGM-JEPA ranks first or second on AUROC for both endpoints across all three regimes while no baseline does, exceeding the strongest baseline by up to $+6.5$ pp in cohort generalization and $+3.6$ pp in venous-to-CGM transfer (paired Wilcoxon, $p<0.001$). Under modality shift, it matches mean AUROC while redistributing toward weaker subgroups (ethnicity AUROC gap shrinks 25-54%); on sparse in-domain venous data, the distributional view lifts label-aware clustering (ARI $+39\%$, NMI $+40\%$). Code and weights: https://github.com/cruiseresearchgroup/CGM-JEPA

Event cameras provide several unique advantages over standard frame-based sensors, including high temporal resolution, low latency, and robustness to extreme lighting. However, existing learning-based approaches for event processing are typically confined to narrow, task-specific silos and lack the ability to generalize across modalities. We address this gap with REALM, a cross-modal framework that learns an RGB- and Event-Aligned Latent Manifold by projecting event representations into the pretrained latent space of RGB foundation models. Instead of task-specific training, we leverage low-rank adaptation (LoRA) to bridge the modality gap, effectively unlocking the geometric and semantic priors of frozen RGB backbones for asynchronous event streams. We demonstrate that REALM effectively maps events into the ViT-based foundation latent space. Our method performs downstream tasks, such as depth estimation and semantic segmentation, by simply transferring linear heads trained on the RGB teacher. Most significantly, REALM enables the direct, zero-shot application of complex, frozen image-trained decoders, such as MASt3R, to raw event data. We demonstrate state-of-the-art performance in wide-baseline feature matching, significantly outperforming specialized architectures. Code and models are available at https://papers.starslab.ca/realm/.

Audio-visual deepfakes have reached a level of realism that makes perceptual detection unreliable, threatening media integrity and biometric security. While multimodal detection has shown promise, most approaches are binary classification tasks that often latch onto dataset-specific artifacts rather than genuine generative traces. We argue that a detector incapable of identifying how a video was forged is likely learning the wrong signal. Unlike binary detection, attribution-guided learning imposes a stronger geometric constraint on the shared embedding space, forcing the model to encode generator-specific forensic content rather than shortcuts. We propose the Attribution-Guided Multimodal Deepfake Detection (AMDD) framework, which jointly learns to detect and attribute manipulation. AMDD treats generator attribution as a structured regularization that constrains representation geometry toward forensically meaningful features. We introduce a Cross-Modal Forensic Fingerprint Consistency (CMFFC) loss to enforce alignment between generator-induced artifacts in visual and audio streams. This exploits the fact that coherent manipulation leaves correlated traces across modalities, grounded in the physical coupling between speech and facial articulation that synthetic pipelines routinely disrupt. Architecturally, we pair a ResNet50 with temporal attention for visual encoding against a pretrained ResNet18 for mel spectrograms, closing the encoder capacity gap found in prior models. On FakeAVCeleb, AMDD achieves 99.7% balanced accuracy and 99.8% AUC with 95.9% attribution accuracy. Cross-dataset evaluation on DeepfakeTIMIT, DFDM, and LAV-DF confirms that real video detection generalizes robustly, while fake detection on unseen generators remains an open challenge that we analyze in depth.

Vision-language models have shown strong performance, but they often generalize poorly to specialized domains. While semi-supervised vision-language learning mitigates this limitation by leveraging a small set of labeled image-text pairs together with abundant unlabeled images, existing methods remain fundamentally pairwise and fail to model the global structure of multimodal representation manifolds. Existing topology-based alignment methods rely on persistence diagram matching, which neither guarantees geometric alignment nor utilizes the image-text pairing information central to vision-language learning. We propose Topology-Aware Multimodal Representation Alignment (ToMA), a framework that uses persistent homology to identify topologically salient edges and aligns them across modalities through available cross-modal correspondences. ToMA leverages both H_0-death edges and lightweight H_1-birth edges, allowing it to capture both connectivity and cycle structure without constructing 2-simplices. Experiments show that ToMA yields stable gains, with clear improvements on remote sensing and modest but consistent benefits on fashion retrieval. Additional analysis shows that ToMA is more stable than alternative topology-based objectives and that lightweight H_1-birth edges provide useful higher-order structural signals.

Human activity recognition serves as the foundation for various emerging applications. In recent years, researchers have used collaborative sensing of multi-source sensors to capture complex and dynamic human activities. However, multimodal human activity sensing typically encounters highly heterogeneous data across modalities and label scarcity, resulting in an application gap between existing solutions and real-world needs. In this paper, we propose CLMM, a general contrastive learning framework for human activity recognition that achieves effective multimodal recognition with limited labeled data. CLMM employs a novel two-stage training strategy. In the first stage, CLMM employs a CNN-DiffTransformer encoder to capture cross-modal shared information by extracting local and global features. Meanwhile, a hard-positive samples weighting algorithm enhances gradient propagation to reinforce shared learning. In the second stage, a dual-branch architecture combining quality-guided attention and bidirectional gated units captures modality-specific information, while a primary-auxiliary collaborative training strategy fuses both shared and modality-specific information. Experimental results on three public datasets demonstrate that CLMM significantly improves state-of-the-art baselines in both recognition accuracy and convergence performance.

Analog circuit design relies heavily on reusing existing intellectual property (IP), yet searching across heterogeneous representations such as SPICE netlists, schematics, and functional descriptions remains challenging. Existing methods are largely limited to exact matching within a single modality, failing to capture cross-modal semantic relationships. To bridge this gap, we present AnalogRetriever, a unified tri-modal retrieval framework for analog circuit search. We first build a high-quality dataset on top of Masala-CHAI through a two-stage repair pipeline that raises the netlist compile rate from 22% to 100%. Built on this foundation, AnalogRetriever encodes schematics and descriptions with a vision-language model and netlists with a port-aware relational graph convolutional network, mapping all three modalities into a shared embedding space via curriculum contrastive learning. Experiments show that AnalogRetriever achieves an average Recall@1 of 75.2% across all six cross-modal retrieval directions, significantly outperforming existing baselines. When integrated into the AnalogCoder agentic framework as a retrieval-augmented generation module, it consistently improves functional pass rates and enables previously unsolved tasks to be completed. Our code and dataset will be released.

Spatial transcriptomics (ST) enables spatially resolved gene profiling but remains expensive and low-throughput, limiting large-cohort studies and routine clinical use. Predicting spatial gene expression from routine hematoxylin and eosin (H&E) slides is a promising alternative, yet under realistic leave-one-slide-out evaluation, existing models often suffer from slide-level appearance shifts and regression-driven over-smoothing that suppress biologically meaningful variation. CHRep is a two-phase framework for robust histology-to-expression prediction. In the training phase, CHRep learns a structure-aware representation by jointly optimizing correlation-aware regression, symmetric image-expression alignment, and coordinate-induced spatial topology regularization. In the inference phase, cross-slide robustness is improved without backbone fine-tuning through a lightweight calibration module trained on the training slides, which combines a non-parametric estimate from a training gallery with a magnitude-regularized correction module. Unlike prior embedding-alignment or retrieval-based transfer methods that rely on a single prediction route, CHRep couples topology-preserving representation learning with post-hoc calibration, enabling stable neighborhood retrieval and controlled bias correction under slide-level shifts. Across the three cohorts, CHRep consistently improves gene-wise correlation under leave-one-slide-out evaluation, with the largest gains observed on Alex+10x. Relative to HAGE, the Pearson correlation coefficient on all considered genes [PCC(ACG)] increases by 4.0% on cSCC and 9.8% on HER2+. Relative to mclSTExp, PCC(ACG) further improves by 39.5% on Alex+10x, together with 9.7% and 9.0% reductions in mean squared error (MSE) and mean absolute error (MAE), respectively.

The Platonic Representation Hypothesis posits that neural networks trained on different modalities (e.g., text and images) converge toward a shared representation of reality. If true, this has significant implications for whether modality choice matters at all. In this paper, we show that the evidence for this claim is substantially weaker than subsequent work suggests. The mutual $k$-nearest-neighbor metric used on 1024 text-image pairs in the original study captures only coarse structure. To keep the alignment from collapsing as one scales up the data, $k$ has to grow proportionally, undercutting the argument for fine-grained representational convergence. The reported increase in alignment with language model strength saturates for recent models. Moreover, the one-to-one text-image pairing favors alignment, while alignment decreases with non-bijective data. We further find that image and text representations indeed share coarse semantic structure, but neither stronger language models nor richer captions yield fine-grained alignment. Thus, multimodal representations share coarse structure without evidence of convergence to a shared representation -- arguably, full representational convergence would require fine-grained alignment.

With the rapid growth of video data, Composed Video Retrieval (CVR) has emerged as a novel paradigm in video retrieval and is receiving increasing attention from researchers. Unlike unimodal video retrieval methods, the CVR task takes a multi-modal query consisting of a reference video and a piece of modification text as input. The modification text conveys the user's intended alterations to the reference video. Based on this input, the model aims to retrieve the most relevant target video. In the CVR task, there exists a substantial discrepancy in information density between video and text modalities. Traditional composition methods tend to bias the composed feature toward the reference video, which leads to suboptimal retrieval performance. This limitation is significant due to the presence of three core challenges: (1) modal contribution entanglement, (2) explicit optimization of composed features, and (3) retrieval uncertainty. To address these challenges, we propose the evidence-dRivRn dual-sTream diRectionAl anChor calibration networK (ReTrack). ReTrack is the first CVR framework that improves multi-modal query understanding by calibrating directional bias in composed features. It consists of three key modules: Semantic Contribution Disentanglement, Composition Geometry Calibration, and Reliable Evidence-driven Alignment. Specifically, ReTrack estimates the semantic contribution of each modality to calibrate the directional bias of the composed feature. It then uses the calibrated directional anchors to compute bidirectional evidence that drives reliable composed-to-target similarity estimation. Moreover, ReTrack exhibits strong generalization to the Composed Image Retrieval (CIR) task, achieving SOTA performance across three benchmark datasets in both CVR and CIR scenarios. Codes are available at https://github.com/Lee-zixu/ReTrack