LLM Agent Orchestration

Large language models(LLMs) are now used to power complex multi-turn agentic workflows. Existing systems run agentic inference by loosely assembling isolated components: an LLM inference engine (e.g., vLLM) and a tool orchestrator (e.g., Kubernetes). Although agentic workflows involve multiple LLM and tool requests, these systems schedule and allocate resources separately on a per-request basis, without end-to-end knowledge of the workflow. This leads to sub-optimal management of KV cache and tool execution environments. To address the challenges, we propose ThunderAgent, a fast, simple, and program-aware agentic inference system. We first abstract agentic workflows as LLM Programs, enabling a unified view of heterogeneous resources, including KV caches, system states, and external tool assets such as disk memory and network ports. Built upon this abstraction, ThunderAgent introduces a program-aware scheduler and a tool resource manager designed to maximize KV cache hit rates, mitigate memory imbalances, and enable asynchronous environment preparation. Evaluations across coding, routing, and scientific discovery agents demonstrate that ThunderAgent achieves 1.5-3.6x throughput improvements in serving, 1.8-3.9x in RL rollout, and up to 4.2x disk memory savings compared to state-of-the-art inference systems. To facilitate reproducibility and support future development, we open-source the system implementations of the whole ThunderAgent at: https://github.com/Agentic-Kinetics/ThunderAgent.

Existing multi-turn image editing paradigms are often confined to isolated single-step execution. Due to a lack of context-awareness and closed-loop feedback mechanisms, they are prone to error accumulation and semantic drift during multi-turn interactions, ultimately resulting in severe structural distortion of the generated images. To address this, we propose IMAGAgent, a multi-turn image editing agent framework based on a ``plan--execute--reflect'' closed-loop mechanism that achieves deep synergy among instruction parsing, tool scheduling, and adaptive correction within a unified pipeline. Specifically, we first present a constraint-aware planning module that leverages a vision-language model (VLM) to precisely decompose complex natural language instructions into a series of executable sub-tasks, governed by target singularity, semantic atomicity, and visual perceptibility. Then, the tool-chain orchestration module dynamically constructs execution paths based on the current image, the current sub-task, and the historical context, enabling adaptive scheduling and collaborative operation among heterogeneous operation models covering image retrieval, segmentation, detection, and editing. Finally, we devise a multi-expert collaborative reflection mechanism in which a central large language model (LLM) synthesizes evaluations from multiple vision-language models into holistic feedback, triggering fine-grained self-correction and recording feedback outcomes to optimize future decisions. Extensive experiments on our constructed MTEditBench and the MagicBrush dataset demonstrate that IMAGAgent achieves performance significantly superior to existing methods in terms of instruction consistency, editing precision, and overall quality. The code is available at https://github.com/hackermmzz/IMAGAgent.

The transition towards sixth-generation (6G) wireless networks necessitates autonomous orchestration mechanisms capable of translating high-level operational intents into executable network configurations. Existing approaches to Intent-Based Networking (IBN) rely upon either rule-based systems that struggle with linguistic variation or end-to-end neural models that lack interpretability and fail to enforce operational constraints. This paper presents a hierarchical multi-agent framework where Large Language Model (LLM) based agents autonomously decompose natural language intents, consult domain-specific specialists, and synthesise technically feasible network slice configurations through iterative reasoning-acting (ReAct) cycles. The proposed architecture employs an orchestrator agent coordinating two specialist agents, namely Radio Access Network (RAN) and Core Network agents, via ReAct-style reasoning, grounded in structured network state representations. Experimental evaluation across diverse benchmark scenarios demonstrates that the proposed system outperforms monolithic agents, rule-based systems, and direct LLM prompting, with architectural principles applicable to Open RAN (O-RAN) deployments. The results also demonstrate that whilst contemporary LLMs possess substantial general telecommunications knowledge, structured prompt engineering encoding domain-specific decision thresholds and operational policies is essential for reliable network automation performance.

LLM-driven agentic applications automate complex, multi-step tasks, but serving them efficiently remains difficult due to heterogeneous components, dynamic model-driven control flow, long-lived state, and highly variable latencies. Nalar is a serving framework for agent workflows that separates workflow specification from execution while providing the runtime visibility and control needed for robust performance. Nalar preserves ordinary Python interfaces and control flow through lightweight auto-generated stubs that turn agent and tool invocations into futures carrying dependency and execution-context metadata. A two-level control architecture combines global policy computation with local event-driven enforcement to support adaptive routing, scheduling, and resource management across evolving workflows. A workflow-aware KV-cache layer enables the runtime to manage cache placement and lifetime. Together, these mechanisms enable scalable, efficient, policy-driven serving of heterogeneous agentic applications without burdening developers with orchestration logic. Across three agentic workloads, Nalar reduces tail latency by 34-74% and achieves up to 3.38x speedups.

The proliferation of Large Language Models (LLMs) has catalyzed a shift towards autonomous agents capable of complex reasoning and tool use. However, current agent architectures are frequently constructed using imperative, ad hoc patterns. This results in brittle systems plagued by difficulties in state management, error handling, and concurrency. This paper introduces Monadic Context Engineering (MCE), a novel architectural paradigm leveraging the algebraic structures of Functors, Applicative Functors, and Monads to provide a formal foundation for agent design. MCE treats agent workflows as computational contexts where cross-cutting concerns, such as state propagation, short-circuiting error handling, and asynchronous execution, are managed intrinsically by the algebraic properties of the abstraction. We demonstrate how Monads enable robust sequential composition, how Applicatives provide a principled structure for parallel execution, and crucially, how Monad Transformers allow for the systematic composition of these capabilities. This layered approach enables developers to construct complex, resilient, and efficient AI agents from simple, independently verifiable components. We further extend this framework to describe Meta-Agents, which leverage MCE for generative orchestration, dynamically creating and managing sub-agent workflows through metaprogramming.

Clinical communication is central to patient outcomes, yet large-scale human annotation of patient-provider conversation remains labor-intensive, inconsistent, and difficult to scale. Existing approaches based on large language models typically rely on single-task models that lack adaptability, interpretability, and reliability, especially when applied across various communication frameworks and clinical domains. In this study, we developed a Multi-framework Structured Agentic AI system for Clinical Communication (MOSAIC), built on a LangGraph-based architecture that orchestrates four core agents, including a Plan Agent for codebook selection and workflow planning, an Update Agent for maintaining up-to-date retrieval databases, a set of Annotation Agents that applies codebook-guided retrieval-augmented generation (RAG) with dynamic few-shot prompting, and a Verification Agent that provides consistency checks and feedback. To evaluate performance, we compared MOSAIC outputs against gold-standard annotations created by trained human coders. We developed and evaluated MOSAIC using 26 gold standard annotated transcripts for training and 50 transcripts for testing, spanning rheumatology and OB/GYN domains. On the test set, MOSAIC achieved an overall F1 score of 0.928. Performance was highest in the Rheumatology subset (F1 = 0.962) and strongest for Patient Behavior (e.g., patients asking questions, expressing preferences, or showing assertiveness). Ablations revealed that MOSAIC outperforms baseline benchmarking.

Large language models (LLMs) promise to accelerate incident response in production systems, yet single-agent approaches generate vague, unusable recommendations. We present MyAntFarm.ai, a reproducible containerized framework demonstrating that multi-agent orchestration fundamentally transforms LLM-based incident response quality. Through 348 controlled trials comparing single-agent copilot versus multi-agent systems on identical incident scenarios, we find that multi-agent orchestration achieves 100% actionable recommendation rate versus 1.7% for single-agent approaches, an 80 times improvement in action specificity and 140 times improvement in solution correctness. Critically, multi-agent systems exhibit zero quality variance across all trials, enabling production SLA commitments impossible with inconsistent single-agent outputs. Both architectures achieve similar comprehension latency (approx.40s), establishing that the architectural value lies in deterministic quality, not speed. We introduce Decision Quality (DQ), a novel metric capturing validity, specificity, and correctness properties essential for operational deployment that existing LLM metrics do not address. These findings reframe multi-agent orchestration from a performance optimization to a production-readiness requirement for LLM-based incident response. All code, Docker configurations, and trial data are publicly available for reproduction.

Chest X-ray (CXR) plays a pivotal role in clinical diagnosis, and a variety of task-specific and foundation models have been developed for automatic CXR interpretation. However, these models often struggle to adapt to new diagnostic tasks and complex reasoning scenarios. Recently, LLM-based agent models have emerged as a promising paradigm for CXR analysis, enhancing model's capability through tool coordination, multi-step reasoning, and team collaboration, etc. However, existing agents often rely on a single diagnostic pipeline and lack mechanisms for assessing tools' reliability, limiting their adaptability and credibility. To this end, we propose CXRAgent, a director-orchestrated, multi-stage agent for CXR interpretation, where a central director coordinates the following stages: (1) Tool Invocation: The agent strategically orchestrates a set of CXR-analysis tools, with outputs normalized and verified by the Evidence-driven Validator (EDV), which grounds diagnostic outputs with visual evidence to support reliable downstream diagnosis; (2) Diagnostic Planning: Guided by task requirements and intermediate findings, the agent formulates a targeted diagnostic plan. It then assembles an expert team accordingly, defining member roles and coordinating their interactions to enable adaptive and collaborative reasoning; (3) Collaborative Decision-making: The agent integrates insights from the expert team with accumulated contextual memories, synthesizing them into an evidence-backed diagnostic conclusion. Experiments on various CXR interpretation tasks show that CXRAgent delivers strong performance, providing visual evidence and generalizes well to clinical tasks of different complexity. Code and data are valuable at this link.

Autonomous agents, from virtual laboratories to biological data-analysis agents and co-scientists, have begun to turn scientific goals into hypotheses. Whether they can go further and convert real, noisy and complex biological data into executable model hypotheses and architectures that encode testable assumptions remains unclear. Predicting how cells respond to genetic and chemical perturbations is a natural test of this ability: it is central to decoding disease mechanisms and therapeutic discovery, yet it demands cross-disciplinary expertise rarely concentrated in a single research group. Here, we introduce CellForge, an organized team of autonomous agents for single-cell perturbation modeling. Given a dataset and a task, it surveys the literature, parses the data, identifies relevant baselines, and formulates a model hypothesis through critic-mediated discussion among agents specialized in data modeling, single-cell biology, and deep learning. It then writes the training code, runs the experiments, and returns a trained predictor including architecture, code, and validation results. The architecture itself is the hypothesis: CellForge produces it end-to-end, with no human specifying the design, loss, or training protocol. Across six perturbation datasets spanning transcriptomic, epigenomic, and proteomic contexts, CellForge yields models that are competitive with hand-crafted state-of-the-art results on established tasks and extends the same workflow to paired multi-omic readouts. Blinded human evaluators rate CellForge's research plans as more scientifically sound and innovative than those from single LLMs or deep-research systems. In summary, we show autonomous agents can complete the full hypothesis-to-validation cycle in single-cell biology, with an AI effectively building another AI, in a complex setting that currently requires a team of human experts.

In financial trading, large language model (LLM)-based agents demonstrate significant potential, but their decisions can be sensitive to noisy and non-stationary market information. We propose ContestTrade, a multi-agent trading system with an internal competitive mechanism inspired by institutional investment workflows. The system consists of two specialized teams: (1) a Data Team that processes and condenses massive market data into diversified textual factors optimized for constrained LLM context windows, and (2) a Research Team that produces parallelized multipath trading decisions via tool-augmented deep research. The core design is a "Quantify-Predict-Allocate" contest mechanism within each team: agent outputs are scored only after market outcomes become observable, future utility is predicted from historical scores, and resources are allocated to agents with positive predicted utility. In a post-2024 A-share backtest, ContestTrade achieves higher backtested return and risk-adjusted performance than the evaluated baselines. We further describe the temporal protocol, implementation choices, and limitations to clarify the scope of these results.

Gene expression analysis holds the key to many biomedical discoveries, yet extracting insights from raw transcriptomic data remains challenging due to the complexity of multiple large, semi-structured files and the need for extensive domain expertise. Current approaches either rely on inflexible workflows that fail in edge cases or fully autonomous agents that lack the precision required for rigorous scientific inquiry. GenoMAS addresses this by presenting a team of LLM-based agents that integrates structured workflows with autonomous adaptability, orchestrating diverse specialized agents through typed message-passing protocols. At its core lies a guided-planning framework where programming agents decompose task guidelines into Action Units and dynamically choose to advance, revise, bypass, or backtrack, maintaining logical coherence while adapting to the idiosyncrasies of genomic data. On the GenoTEX benchmark, GenoMAS achieves 89.13% CSC for data preprocessing and 60.48% $F_1$ for identifying trait-associated genes, surpassing prior art by 10.61% and 16.85%. Beyond transcriptomics, it outperforms strong agent baselines on ScienceAgentBench and DiscoveryBench, two independent bioinformatics benchmarks. Qualitative analysis shows that GenoMAS identifies gene-phenotype associations that are biologically plausible and corroborated by the literature.

AI for Industrial Asset Lifecycle Management aims to automate complex operational workflows, such as condition monitoring and maintenance scheduling, to minimize system downtime. While traditional AI/ML approaches solve narrow tasks in isolation, Large Language Model (LLM) agents offer a next-generation opportunity for end-to-end automation. In this paper, we introduce AssetOpsBench, a unified framework for orchestrating and evaluating domain-specific agents for Industry 4.0. AssetOpsBench provides a multimodal ecosystem comprising a catalog of four domain-specific agents, a curated dataset of 140+ human-authored natural-language queries grounded in real industrial scenarios, and a simulated, CouchDB-backed IoT environment. We introduce an automated evaluation framework that uses three key metrics to analyze architectural trade-offs between the Tool-As-Agent and Plan-Executor paradigms, along with a systematic procedure for the automated discovery of emerging failure modes. The practical relevance of AssetOpsBench is demonstrated by its broad community adoption, with 250+ users and over 500 agents submitted to our public benchmarking platform, supporting reproducible and scalable research for real-world industrial operations. The code is accesible at https://github.com/IBM/AssetOpsBench .

In customer contact centers, human agents often struggle with long average handling times (AHT) due to the need to manually interpret queries and retrieve relevant knowledge base (KB) articles. While retrieval augmented generation (RAG) systems using large language models (LLMs) have been widely adopted in industry to assist with such tasks, RAG faces challenges in real-time conversations, such as inaccurate query formulation and redundant retrieval of frequently asked questions (FAQs). To address these limitations, we propose a decision support system that can look beyond RAG by first identifying customer questions in real time. If the query matches an FAQ, the system retrieves the answer directly from the FAQ database; otherwise, it generates answers via RAG. Our approach reduces reliance on manual queries, providing responses to agents within 2 seconds. Deployed in AI-powered human-agent assist solution at Minerva CQ, this system improves efficiency, reduces AHT, and lowers operational costs. We also introduce an automated LLM-agentic workflow to identify FAQs from historical transcripts when no predefined FAQs exist.