Multimodal Contrastive Learning

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16 papers in the last four weeks, up 45% on the four weeks before. 0.2% of all new papers.

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Latest papers 153

Jun 30, 2026cs.IR

Unsupervised Data-Efficient Cross-Modal Retrieval with Global-Neighborhood Alignment Hashing

Compared to supervised cross-modal hashing (CMH), unsupervised CMH reduces the reliance on manual labeling by learning binary codes from unlabeled image-text pairs. However, existing unsupervised CMH methods often rely on large-scale image-text pairs, which are costly to collect. To address this limitation, we propose Global-Neighborhood Alignment Hashing (GNAH), a novel approach that preserves the semantic structure of vision-language foundation models within a compact binary Hamming space using only a limited number of image-text pairs. Specifically, GNAH captures global structural information from the continuous latent space and transfers it into the binary Hamming space through a Prototype-Anchored Global Alignment module. In addition, GNAH extends conventional pairwise contrastive learning by modeling stochastic neighborhood relationships via a Contrastive Stochastic Neighborhood Alignment module, thereby alleviating overfitting to sparse pairwise correlations. Extensive experiments demonstrate that GNAH consistently outperforms existing unsupervised cross-modal retrieval methods under data-constrained settings, offering a practical solution for real-world CMH applications.

Runhao Li, Xiaoxu Ma, Zhenyu Weng +5

School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore · Shien-Ming Wu School of Intelligent Engineering, South China University of Technology, China · College of Computer and Information Engineering, Henan Normal University, China +2

Cross-Modal Alignment Cross-Modal Retrieval Multimodal Contrastive Learning

Jun 29, 2026eess.IV

Data-Efficient Multimodal Alignment for Histopathology-based Molecular Prediction

H&E-stained whole-slide images offer cohort-scale availability and rich spatial context but lack molecular specificity, whereas bulk RNA-seq provides transcriptome-wide resolution at high cost with limited archival availability. We show that training a lightweight alignment module atop frozen histopathology and RNA-Seq foundation models enables open-vocabulary molecular prompting -- querying H&E slides with gene-set signatures to predict pathway activity without sequencing or end-to-end retraining. Using contrastive learning on a multi-cancer cohort (N=1,720), we achieve a 25-fold improvement in retrieval over baseline methods. Systematic analysis reveals a graduated predictability spectrum: morphologically grounded programs (cell-cycle programs, immune-related) are most reliably predicted (R^2>0.5), while predicting pathways with no morphological footprint remains challenging as expected. We validate clinical utility on the POSEIDON clinical trial: H&E-predicted squamous cell carcinoma scores recapitulate NSCLC subtype identity and predicted IFN-gamma mirror PD-L1 tumor-cell expression groups. Furthermore, genesets describing immune activation and fibrosis predict known tumor microenvironment archetypes from histology alone. We further validate generalization of our approach across unseen cohorts and demonstrate data-efficient domain adaptation, establishing a slide-native framework for molecular analysis on H&E images.

Dominik Winter, Dominik Vonficht, Loïc Le Bescond +6

AstraZeneca Computational Pathology and Biomarkers, Munich, Germany · AstraZeneca, Early Oncology and Translation Medicine, Cambridge, UK

Computational Pathology Cross-Modal Alignment Pathology Foundation Models Oncology Multimodal Contrastive Learning Gene Expression Prediction from Histopathology Images+1

Jun 28, 2026cs.CV

SonoCLIP: Mask-Guided Region-Aware Vision-Language Pretraining for Fetal Ultrasound Analysis

Vision-language foundation models have shown strong potential in medical image analysis. Although foundation models for ultrasound imaging have recently emerged, the domain remains particularly challenging due to severe speckle noise, acquisition variability, and subtle anatomical boundaries, leading to high inter-observer variability. Existing CLIP-based models rely primarily on global image-text alignment, limiting their sensitivity to clinically decisive local structures. We propose SonoCLIP, the first million-scale region-controllable fetal ultrasound vision-language foundation model that integrates segmentation masks as mask-channel visual prompts within the vision encoder, enabling joint global-local contrastive representation learning. To support scalable region-text alignment, we introduce a sigmoid-based pairwise contrastive loss that improves stability under large-scale supervision. We further curate a 1.44M-image multimodal fetal ultrasound dataset spanning 24 standard planes for large-scale pretraining. Extensive cross-center evaluations demonstrate that SonoCLIP achieves superior zero-shot transfer performance under both global and mask-guided inference, establishing a controllable and clinically oriented foundation model for fetal ultrasound analysis. Our code and data are available at https://github.com/Harrison-one/SonoCLIP.

Hang Su, Chao Sun, Zhaofan Li +3

School of Computer Science, Wuhan University, Wuhan, China · Institute of Artificial Intelligence, Wuhan University, Wuhan, China · Department of Ultrasound, Renmin Hospital of Wuhan University, Wuhan, China +2

Medical Imaging Foundation Models Ultrasound Imaging Medical VLMs Multimodal Contrastive Learning Vision-Language Pretraining

Jun 28, 2026cs.CV

Rank-Aware Hyperbolic Alignment for Vision-Language Dataset Distillation

Vision-language dataset distillation (VLDD) compresses a large image-text paired dataset into a small set of synthetic pairs that can efficiently train contrastive vision-language models under strict data and compute budgets. Most existing methods match expert trajectories or cross-modal statistics, yet still enforce full-dimensional alignment in a Euclidean embedding space. This is often overly restrictive due to rank-deficient image--text correlation, with shared semantics concentrated in a low-dimensional range and remaining variation spread across a weakly correlated residual subspace. LoRS relaxes alignment at the similarity level by low-rank factorization, but does not explicitly control dominant alignment capacity and structure in the representation space. We thus propose a rank-aware hyperbolic alignment (RAHA) that combines hierarchical geometry with explicit alignment-capacity control. RAHA lifts multimodal representations to hyperbolic space and optimizes distilled pairs with asymmetric objectives that enforce geodesic alignment in the shared range while regularizing the residual subspace to preserve modality-private diversity and improve transfer robustness. Experiments on benchmarks show that RAHA demonstrates competitive cross-modal retrieval and improved transfer indicators under fixed budgets.

Jongoh Jeong, Sun-Kyung Lee, Kuk-Jin Yoon

Korea Advanced Institute of Science and Technology (KAIST), Republic of Korea · Electronics and Telecommunications Research Institute (ETRI), Republic of Korea

Dataset Distillation Vision-Language Alignment Multimodal Contrastive Learning Hyperbolic Representation Learning

Jun 28, 2026cs.RO

TacGen: Touch Is a Necessary Dimension of Physical-World Representation -- Addressing Tactile Data Scarcity with Scalable Vision-to-Touch Alignment and Generation

Touch resolves the physical-property ambiguity left by vision: exploratory contact recovers shape, texture, compliance, and material, and visuo-haptic object representations converge in ventral visual cortex. We ask whether representation learning can reproduce this grounding. TacGen mitigates the tactile-data scarcity bottleneck by combining pre-specified V+T contrastive alignment with a latent-space residual-MLP V->T generator that synthesizes tactile latents from RGB for tactile-data scaling. With matched DINOv2 backbones, splits, and probes, V+T improves matched V-only on mass (Delta R^2=+0.570), density (Delta acc=+0.067), hardness (+0.117), and uncertainty-banded force labels (Delta R^2=+0.281); all CIs exclude zero. The same representation lifts matched-capacity TACTO manipulation 0.246->0.979 while V-only capacity scaling accounts for only 4.5% of the gap, preserving 95.5%. The generator reaches cross-seed +0.589, with real tactile +0.585 inside the seed interval; the architecture comparison shows a 13pp downstream gap between reconstruction quality and representation utility. Across five-seed SSVTP/TVL reproductions, YCB-Sight transfer, three-backbone checks, permutation/random-feature controls, hash-verified manifests, and measured-force validation checks, the evidence supports the claim that touch supplies a necessary physical evidence channel for representations of contact-dependent properties.

Wanghao Ye, Aarosh Das, Sihan Chen +19

University of Maryland, College Park · Carnegie Mellon University · University of Alabama +2

Visuo-Tactile Representation Learning Multimodal Contrastive Learning Tactile Sensing for Robotic Manipulation

Jun 27, 2026cs.CV

Learning from Acquisition: Metadata-driven Multimodal Pre-training for Cardiac MRI

Cardiac magnetic resonance imaging (CMR) routinely records structured acquisition metadata, yet most CMR foundation models rely primarily on image-only pre-training and leave this naturally available source of weak semantic supervision largely underexplored. We propose MetaCLIP-CMR, a metadata-driven framework based on Contrastive Language--Image Pre-training (CLIP), which converts imaging modality, anatomical view, scanner vendor, field strength, and scanner model into textual supervision for CMR representation learning. The pretrained image encoder is evaluated on imaging modality classification, cine view classification, and cardiac segmentation. MetaCLIP-CMR achieves 86.8% modality accuracy and 86.5% cine view accuracy, clearly outperforming ImageNet and masked reconstruction initialisations. For downstream cardiac segmentation, MetaCLIP-CMR consistently obtains the highest Dice score across the evaluated ACDC and M&Ms cine short-axis (SAX) settings under both full-data and 20% fine-tuning regimes. Compared with recent image-focused large-scale CMR pre-training models, MetaCLIP-CMR achieves comparable ACDC segmentation performance, while requiring less than 1% of their pre-training image scale. These results suggest that metadata learning offers a natural and easy-to-use strategy for transforming routinely recorded acquisition information into effective supervision for foundation-level CMR representation learning, highlighting the promise of metadata-driven multimodal pre-training.

Xueyi Fu, Liwei Hu, Zi Wang +1

Department of Surgery & Cancer, Imperial College London, London, UK · Bioengineering Department and Imperial-X, Imperial College London, London, UK · National Heart and Lung Institute, Imperial College London, London, UK +2

Medical Image Segmentation Multimodal Contrastive Learning Medical Image Representation Learning Cardiac MRI

Jun 26, 2026cs.CV

Text as Illumination: Spatial Contrastive Retinex Learning for Language-guided Medical Image Segmentation

Language-guided Medical Image Segmentation (LMIS) has shown great potential to improve the delineation of anatomical structures and lesions by integrating clinical textual information. Existing methods generally rely on either implicit interaction between textual and visual features or auxiliary coarse-grained supervision for cross-modal alignment. However, these methods lack explicit and fine-grained constraints to ensure semantic consistency, causing a mismatch between language and the segmentation outputs. To address this issue, we propose Text-as-Illumination Retinex Network (TIRNet), a novel Retinex-inspired framework that treats text embeddings as semantic illumination for feature modulation, thereby improving semantic consistency in LMIS. TIRNet introduces two key blocks integrated at each decoder stage: (1) the Retinex-inspired Text Modulation Block (RTMB), which employs positive and negative illumination maps to enhance text-relevant foreground features and suppress background interference; and (2) the Consistent Detail Compensation Block (CDCB), which selectively recovers high-frequency details via a consistency-gated mechanism conditioned on illumination reliability. Furthermore, we propose a Multi-Scale Illumination Supervision Loss (MSIS-Loss), comprising a Region-Grounded Contrastive Loss (RGC-Loss) that enforces cross-modal similarity to be concentrated in text-relevant foreground regions and suppressed in background regions, and a Background Suppression Loss (BS-Loss) that provides pixel-level supervision for negative illumination maps, jointly ensuring a precise cross-modal alignment at each decoder stage. Extensive experiments on the MosMedData+ and QaTa-COV19 datasets demonstrate that TIRNet achieves state-of-the-art performance in LMIS. The code is available at: https://github.com/anaanaa/TIRNet.

Jian Shi, Cheng Zhen, Pingping Zhang +6

School of Software Technology & DUT-RU International School of Information Science and Engineering, Dalian University of Technology, Dalian, China · School of Future Technology, Dalian University of Technology, Dalian, China · Central Hospital of Dalian University of Technology, Dalian, China +2

Text-Guided Image Segmentation Medical Image Segmentation Multimodal Contrastive Learning

Jun 25, 2026eess.IV

DFM: Difference Feature Modeling with Text-Guided Gated Contrastive Loss for Remote Sensing Image Change Captioning

The primary goal of Remote Sensing Image Change Captioning (RSICC) is to automatically generate descriptions of changes between remote sensing images captured at different time points. Existing models still rely on a single autoregressive generation paradigm, which tends to prioritize learning easily generated vocabulary over capturing discriminative differences between images. To address this, we reframe the training paradigm and propose a novel Difference Feature Modeling (DFM) framework. Specifically, we introduce a Text-guided Gated Contrastive Loss (TGCL) to guide the vision encoder to extract critical features from a text-modal perspective. Additionally, we incorporate a pre-trained Change Detection model to transfer stable change detection knowledge. In order to further enhance the representation, we design a Joint Feature Modeling (JFM) module to achieve the fusion of multi-scale difference representations, thereby capturing comprehensive spatiotemporal variations between multi-temporal images. Extensive experiments on multiple datasets demonstrate the effectiveness of our approach.

Yelin Wang, Zijia Song, Chuanguang Yang +4

ShanghaiTech University · National University of Defense Technology · Institute of Computing Technology, Chinese Academy of Sciences +1

Remote Sensing Image Understanding Remote Sensing Image Change Captioning Remote Sensing Multimodal Contrastive Learning

Jun 23, 2026cs.CV

Jolia: Concept-Level Vision-Language Alignment for 3D CT Contrastive Learning

Vision-language contrastive pretraining has become the dominant recipe for 3D medical foundation models, leveraging the large volumes of paired scans and reports produced in clinical practice. However, medical images usually span dozens of organs, and radiological reports are much longer than typical natural image captions and are composed of multiple structured sections. CLIP-style pretraining compresses this structure by encoding each modality into a single global token, at the risk of losing important details. We introduce ConQuer (Concept Queries), an image-text pretraining method that augments CLIP's global alignment with a set of localized alignments, one per concept. ConQuer splits the report into concept-specific sections and learns cross-attention queries that pool the matching image features without using any segmentation mask or spatial supervision. Contrastive learning is then applied independently for each concept. Concepts can be any unit of semantic localization; here, they are anatomical regions, one query per organ or gross body region. As a byproduct, each query learns attention maps focused on its concept, providing built-in spatial interpretability. We use ConQuer to train Jolia, a 3D CT foundation model on chest and abdominal CT. Jolia consistently outperforms a CLIP baseline on findings classification, report generation, and cross-center transfer, and sets a new state of the art across multiple public benchmarks. Jolia's weights are available at https://huggingface.co/raidium/Jolia

Julien Khlaut, Charles Corbière, Baptiste Callard +9

Raidium, Paris, 75014, France · Department of Vascular and Oncological Interventional Radiology,2026 Hôpital Européen Georges Pompidou, AP-HP, Paris, France · Faculté de Santé, Université Paris-Cité, Paris, France +3

3D Foundation Models Medical Imaging Foundation Models Explainable Medical Image Analysis Multimodal Foundation Models Vision-Language Alignment Multimodal Contrastive Learning+1

Jun 22, 2026cs.CV

Mind the Heads: Topological Representation Alignment for Multimodal LLMs

Representation alignment has emerged as an effective approach to improve Multimodal Large Language Models (MLLMs) by regularizing their internal representations toward those of an external vision encoder. However, existing methods typically align a fixed layer of the language backbone, overlooking the fine-grained structure of Transformer models. In this work, we propose Head-Wise Representation Alignment (HeRA), a method that enforces cross-modal alignment at the level of individual attention heads. Our approach is grounded in the Platonic Representation Hypothesis, focusing on preserving the topological structure of representations (i.e., their local neighborhood relationships) across modalities. Following the Mutual K-Nearest Neighbor (MKNN) alignment metric, we introduce a contrastive objective that acts as a differentiable proxy for matching local structures. HeRA applies this objective during multimodal training to specific attention heads in the LLM, selected by their alignment score according to the MKNN metric. Counterintuitively, we find that aligning the least aligned heads yields the largest gains. Extensive evaluations across multiple MLLMs and 18 benchmarks demonstrate that HeRA consistently improves performance on challenging vision-centric tasks and serves as an effective regularizer against visual hallucinations by naturally curbing the over-reliance on linguistic priors. Our code is publicly released.

Davide Caffagni, Alberto Compagnoni, Federico Melis +5

University of Modena and Reggio Emilia · University of Pisa · AMD Silo AI

Cross-Modal Alignment Multimodal Large Language Models Multimodal Foundation Models Multimodal Contrastive Learning VLM Hallucination Mitigation

Jun 21, 2026cs.CV

MAPS: Multi-Anchor Projection Similarity for Joint Vision-Language Geo-Localization

Humans localize places by integrating perceptual cues from vision with semantic reasoning from language, forming a scene understanding that is both intuitive and structured. Although existing geo-localization models have made substantial progress in cross-view and cross-modal settings, they are largely built upon point-to-point alignment, which is insufficient for joint vision-language queries. In such queries, visual and textual cues do not simply act as independent references, but jointly define a semantic subspace for locating the target. In this paper, we formulate vision-language geo-localization (VLGL) with joint image-text queries as a multi-anchor geometric alignment problem and propose a unified framework for this setting. To realize this formulation, we propose Multi-Anchor Projection Similarity (MAPS), a new metric which constructs an anchor plane from visual and textual query features in a high-dimensional space and measures similarity by the projection length of the target feature onto this plane. Unlike cosine similarity which evaluates isolated pairwise relations, MAPS captures the geometric consistency between the target feature and the joint query subspace, providing a more discriminative ranking criterion during retrieval. To make the learned representation consistent with this geometry, we further introduce a MAPS-based contrastive loss that drives target features toward the corresponding anchor plane. The proposed framework, similarity metric, and training objective jointly yield state-of-the-art performance in VLGL.

Yutong Hu, Siyuan Tan, Shaocheng Yan +3

School of Remote Sensing and Information Engineering, Wuhan University, Wuhan 430079, China

Cross-View Geo-Localization Geometric Representation Learning Vision-Language Retrieval Multimodal Contrastive Learning

Jun 20, 2026cs.CV

MultiMem: Measuring and Mitigating Memorization in Multi-Modal Contrastive Learning

Memorization in machine learning models enables high performance on rare in-distribution samples by capturing their atypical patterns. However, it also causes harmful retention of noise and outliers, degrading generalization. While memorization has been extensively studied in both supervised and self-supervised learning in the vision domain, it remains unexplored in multi-modal contrastive learning. We address this gap by introducing MultiMem, the first metric designed to quantify memorization in multi-modal contrastive learning. Through our systematic analysis, we demonstrate that cross-modal semantic misalignment has the strongest influence on memorization, with text being the dominant modality driving memorization, followed by video, image, and audio. We show that targeted augmentations applied across all modalities effectively reduce memorization as measured by our MultiMem metric and improve model performance. Overall, this work establishes the first framework for measuring and mitigating memorization in multi-modal contrastive learning, preventing harmful data retention and contributing to higher-performing models.

Wenhao Wang, Franziska Boenisch, Michael Backes +1

CISPA Helmholtz Center for Information Security

Multimodal Contrastive Learning

Jun 20, 2026cs.CV

Beyond Flat Labels: Level-Restricted Contrastive Learning for Hierarchical Fine-Grained Vision Classification

Multimodal contrastive learning has enabled zero-shot visual classification by aligning images with textual categories. However, in hierarchically structured label spaces, existing methods often produce predictions that are inconsistent across taxonomic levels. For example, a model may predict a fine-grained category whose parent category contradicts its simultaneously predicted higher-level label. By analysis, the issue originates from false negative labels when contrastive comparison involves multiple taxonomic levels. To this end, we propose to restrict contrastive comparisons to categories within the same taxonomic level. In addition, we adopt a group-balanced design, ensuring each taxonomic level receives adequate optimization. As a result, the proposed framework improves both hierarchical consistency and classification accuracy from coarse to fine granularity. We train our model with TreeOfLife-10M based on BioCLIP and evaluate it across multiple hierarchical classification benchmarks, where the model demonstrates significantly improved hierarchical consistency in both Euclidean and hyperbolic spaces. Notably, on iNaturalist 2021 (iNat21), our method improves average accuracy across levels by 30.47% over the baseline, highlighting its effectiveness for hierarchical zero-shot classification.

Zhiyuan Tao, Srikumar Sastry, Matthew J Thompson +9

The Ohio State University · Washington University in St. Louis · Neuromatch +1

Hierarchical Classification Contrastive Learning Fine-Grained Image Classification Zero-Shot Image Classification Multimodal Contrastive Learning

Jun 18, 2026cs.LG

Multi-Modal Contrastive Learning for Implicit Earth Embeddings via Location Tying

Spatial prediction tasks are often limited by a lack of high-quality labelled ground-truth observations. To overcome this challenge, self-supervised pre-training is a possible solution, with contrastive learning dominant for location encoders. Those approaches usually align geographic coordinates with just one additional modality. We propose two multimodal contrastive learning architectures: Multimodal Embedding via Location Tying (MELT) and Sequential Alternating Location Training (SALT). These architectures expand this framework beyond two modalities by utilising unpaired geospatial data. Both methods are technically viable and match the performance of the strongest two-modality baseline (SATCLIP) across four downstream tasks. However, increasing the number of modalities does not consistently improve performance, suggesting that the chosen location encoder is the main limitation - the contrastive objective reaches its peak early, regardless of modality diversity or pre-training volume. MELT provides more stable training than SALT and presents a stronger foundation for future scaling.

Jonathan Hecht, Lukas Arzoumanidis, Ziyue Li +1

Computational Methods Lab, HafenCity University Hamburg, Germany. · Institute of Geodesy and Geoinformation, University of Bonn, Germany. · Dept. of Operations & Technology, Technical University of Munich; Heilbronn Data Science Center; Munich Data Science Institute.

Self-Supervised Pre-Training Geospatial Representation Learning Multimodal Pretraining Multimodal Contrastive Learning

Jun 18, 2026cs.CV

Exploring Multi-Modal Large Language Models and Two-Stage Fine-Tuning for Fashion Image Retrieval

Composed image retrieval retrieves a target image using a composed query of a reference image and a modified text description. In the fashion domain, this task requires understanding subtle attribute variations such as color, pattern, and texture. However, existing approaches face limitations due to scarce annotated data and simplistic negative sampling. We propose a novel framework that integrates a multi-modal large language model (LLaVA) to generate attribute-aware triplets and introduces a two-stage fine-tuning strategy to enhance contrastive learning. We leverage pretrained vision-language models, such as CLIP-ViT/B32, to generate and concatenate sentence-level prompts with the relative caption and to scale the number of negatives using static representations. Experimental results demonstrate enhanced compositional reasoning and improved fine-grained retrieval behavior, underscoring the feasibility and potential of the proposed framework for fashion retrieval.

Nguyen Cao Hoang, Hoang Bui Le, Nam Vo Hoang +1

University of Science, VNU-HCM, Ho Chi Minh, Vietnam · Vietnam National University, Ho Chi Minh, Vietnam

Multimodal Large Language Models Image-Text Retrieval Multimodal Contrastive Learning Composed Image Retrieval

Jun 17, 2026cs.AI

REVEAL++: Differentiable Phenotypic Grouping for Vision-Language Retinal Modeling of Alzheimer's Disease Risk

The retina offers a noninvasive window into neurodegenerative disease, capturing subtle structural patterns associated with a risk of future cognitive decline. Vision-language alignment frameworks such as REVEAL have shown that pairing retinal fundus images with structured clinical risk narratives improves early prediction of Alzheimer's disease (AD). A key design choice in these approaches is the use of phenotypic grouping, where individuals with similar risk profiles are treated as multi-positive pairs during contrastive learning. However, existing methods operationalize phenotypic similarity as a discrete construct, relying on hard group assignments that impose rigid supervision and decouple group formation from representation learning. We propose a continuous formulation of phenotypic structure within contrastive learning. Rather than assigning samples to fixed clusters, we model inter-subject similarity as a differentiable weighting function derived from intra-modality embedding similarities in both retinal images and risk profiles. These weights define soft multi-positive relationships through a continuous aggregation operator, enabling graded supervision that reflects the spectrum nature of disease risk. We further introduce a soft-target contrastive objective that jointly learns cross-modal alignment and phenotypic structure in an end-to-end manner. Evaluated on UK Biobank retinal imaging data for incident AD prediction, the proposed framework consistently outperforms discrete group-based contrastive learning and standard vision-language baselines. By treating phenotypic similarity as a learnable, continuous signal rather than a fixed grouping rule, our approach provides a principled and robust foundation for population-scale neurodegenerative risk modeling from multi-modal retinal and clinical data.

Ethan Elio Meidinger, Seowung Leem, Zeyun Zhao +1

University of Virginia, Charlottesville, VA, USA · J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA

Contrastive Learning Medical Image Analysis Medical VLMs Alzheimer's Disease Classification Multimodal Contrastive Learning Medical Image Representation Learning

Jun 17, 2026cs.RO

TactSpace: Learning a Physics-enriched Shared Latent Space for Tactile Sim-to-Real Transfer

Tactile sensing provides direct measurements of contact interactions that are essential for robotic manipulation. However, current simulators lack the fidelity to faithfully model the complex deformation and transduction mechanics of tactile sensors, severely hindering sim-to-real transfer in robot learning pipelines. To address this challenge, we propose a multi-modal representation learning framework that aligns heterogeneous tactile modalities within a shared latent space, eliminating the need for accurate raw-signal simulation while preserving relevant contact information. Our approach employs modality-specific encoders to project diverse tactile observations, such as simulated penetration depth and real-world capacitance, into a common embedding space. The model is trained using self- and cross-reconstruction objectives alongside contrastive alignment, encouraging modality-invariant yet information-rich representations. We evaluate the learned embeddings on indenter shape identification, force prediction, and geometric reconstruction tasks, training exclusively in simulation and testing directly on real sensor measurements. Our results demonstrate zero-shot sim-to-real transfer across physically dissimilar representations. Furthermore, incorporating multi-physics simulation modalities yields more informative embeddings that transfer across diverse downstream tasks, demonstrating a 16.7% reduction in force prediction error and a 45.8% reduction in shape reconstruction error. Finally, we release an efficient Warp-based implementation of a penalty-based tactile simulation model for Isaac Lab, enabling scalable tactile data generation.

Arunim Joarder, Arjun Bhardwaj, René Zurbrügg +6

Robotic Systems Lab, ETH Zürich · ETH AI Center · NVIDIA +1

Cross-Modal Representation Learning Tactile Sensing Robotics Simulation Sim-to-Real Transfer Multimodal Contrastive Learning

Jun 17, 2026cs.LG

Contextualizing Biological Language Models across Modalities via Logit-Space Contrastive Alignment

Pretrained biological language models expose per-token probability distributions through masked-token prediction, providing the likelihood interface central to sequence design, variant scoring, and mechanistic interpretation. Yet these distributions are learned from broad unlabeled corpora and are not naturally conditioned on task-specific biological contexts such as interaction partners, cellular environments, or therapeutic interventions. Existing contextual matching methods often distort this interface through pooled embeddings, contrastive latent spaces, or task-specific prediction heads. We introduce LOGICA (Logit-space Contrastive Alignment), a framework for context-conditioned prediction that performs contrastive learning directly in output-logit space. Using gated cross-modal adapters compatible with each model's native token head, LOGICA preserves the pretrained likelihood interface and converts contextualized token log-likelihoods into matching scores. Alignment is defined through context-sensitive token probabilities rather than proximity in a shared embedding space, enabling learning from sparse paired data across models with distinct vocabularies, without a shared tokenizer or decoder. LOGICA is particularly effective for mutation-local variant ranking, where comparisons reduce to context-conditioned likelihoods of mutant tokens at perturbed sites. Across protein--ligand binding, TCR--peptide activity, and drug-conditioned resistance prediction, LOGICA improves over prior state-of-the-art methods, including matched latent-contrastive and conditional MLM baselines, while retaining a token-level interface for interpretation and generation. On held-out-gene single-mutation drug-resistance prediction, LOGICA improves AUC from near-random latent-space baselines of

\sim

0.55 to

\sim

0.65.

Yanjun Shao, Yundi Chen, Yashvi Patel +2

Biomedical Informatics and Data Science, Yale School of Medicine, United States · Institute of Computational Life Sciences, Zürich University of Applied Sciences (ZHAW), Switzerland

Contrastive Learning Protein Language Models Multimodal Contrastive Learning

Jun 15, 2026cs.CV

SUP-MCRL: Subject-aware Unified Pseudo-feature Coded Multimodal Contrastive Representation Learning for EEG Visual Decoding

Non-invasive brain-computer interfaces exhibit significant performance degradation when moving from controlled laboratory stimuli to real-world natural images. This degradation occurs because conventional multimodal contrastive representation learning models focus exclusively on optimizing geometric distance alignment, thereby failing to account for semantic consistency and inter-subject variability in neural representation and selective attention. As a result, these models are prone to producing spurious zero-shot matches. To address these limitations, we propose SUP-MCRL, a unified framework integrating three collaborative mechanisms: (1) a Semantic-entity Aware Visual Encoder (SAVE) that learns spatial attention to extract semantic content without relying on pre-trained saliency models; (2) a Unified EEG Enhancer (UEE) that employs multi-scale atrous convolutions and inter-band attention for adaptive cross-subject robustness; and (3) a Prototype-based Progressive Augmenter (PPA) that maintains an EMA-updated pseudo-feature pool to prevent representation collapse. Zero-shot experiments on the THINGS-EEG achieve 66.0%/91.9% (Top-1/Top-5) intra-subject and 24.0%/52.9% LOSO accuracy, significantly surpassing state-of-the-art methods and demonstrating that structured alignment supervision is key to overcoming the limitations of cross-modal decoding. Code is available at https://github.com/NZWANG/SUP-MCRL.

Shengyu Gong, Weiming Zeng, Yueyang Li +4

Lab of Digital Image and Intelligent Computation, Shanghai Maritime University, Shanghai 201306, China · Department of Language Science and Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong Special Administrative Region, China · Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222002, China

Cross-Subject EEG Decoding Contrastive Learning EEG Decoding EEG-Based Visual Decoding Multimodal Contrastive Learning

Jun 13, 2026eess.SP

CAP: Towards PPG Universal Representation Learning with Patient-level Supervision

Photoplethysmography (PPG) plays a central role in wearable health monitoring and clinical decision support. Yet existing approaches to universal PPG representation learning largely focus on signal-level objectives and often overlook patient-level health context, which limits generalization to complex clinical tasks and heterogeneous cohorts. To address this gap, we construct a large-scale paired PPG-EHR multimodal dataset by distilling fragmented medical histories and clinical records into cohesive, patient-level electronic health records (EHR). Building on this resource, we propose Clinical Anchored Pretraining for PPG (CAP). During pretraining, CAP performs cross-modal contrastive alignment that anchors PPG representations to patient-level clinical semantics, guiding the encoder beyond waveform fitting toward modeling consistency in a patient's overall physiological state. During downstream adaptation, the pretrained PPG encoder provides clinically grounded representations that strengthen inductive bias and improve robustness and transferability. Experiments demonstrate that CAP consistently outperforms strong baselines on four diverse downstream tasks. CAP achieves a particularly large gain on respiratory rate prediction (up to +87.6% relative improvement over the state-of-the-art baseline) and delivers an average relative +26.7% across all tasks. We further enhance the interpretability of our approach through comprehensive analyses, including ablations and multiple complementary visualizations of the learned representations. The code for our experiments is available at: https://github.com/gody123gody/CAP .

Chenyang He, Xinyi Shao, Shun Huang +4

Nanjing University of Aeronautics and Astronautics Nanjing, Jiangsu, China · Peking University Beijing, Beijing, China · Independent Researcher +1

Representation Learning Cross-Modal Representation Learning Multimodal Pretraining Photoplethysmography Multimodal Contrastive Learning Wearable Health Monitoring

Jun 12, 2026eess.IV

Trimodal Glioma Representation Alignment via Volumetric Contrastive Learning

Glioma grading and survival prediction require the integration of heterogeneous information collected at different spatial and biological scales. Histopathology describes tissue morphology, mRNA expression captures molecular activity, and magnetic resonance imaging provides a non-invasive view of tumor extent and radiological heterogeneity. Existing glioma prognosis models often combine only two of these sources, while their alignment objectives remain mostly pairwise. This paper introduces GLORIA, a novel trimodal framework for GLioma Omics - Radiology - hIstopathology Alignment. GLORIA processes whole-slide image regions, gene-expression profiles, and 3D MRI volumes through modality-specific encoders, projects them into a shared latent space, and aligns them with a Gramian contrastive loss that measures the volume spanned by the three modality embeddings. The aligned representations are fused through a cross-modal gating module and optimized jointly for three-class glioma grading and overall survival prediction. We evaluate GLORIA on a matched TCGA-GBM/LGG and BraTS21 cohort, comprising 132 patients with all three modalities. On the shared trimodal test set, GLORIA improves over the bimodal WSI-mRNA baseline in all the metrics considered.

Denise Marini, Eleonora Grassucci, Danilo Comminiello

Dept. of Information Engineering, Electronics, and Telecommunications, Sapienza University of Rome, Italy

Cancer Survival Prediction Cross-Modal Alignment Oncology Multimodal Survival Analysis Multimodal Contrastive Learning Multimodal Fusion

Jun 11, 2026cs.CV

LaME: Learning to Think in Latent Space for Multimodal Embedding via Information Bottleneck

Reasoning-driven universal multimodal embedding has advanced rapidly by introducing Chain-of-Thought (CoT) reasoning into the embedding pipeline. Despite the strong performance across both general and complex tasks, this paradigm suffers from two core limitations: (i) autoregressive CoT reasoning incurs high computational cost, making it impractical for low-latency retrieval; and (ii) embedding performance is heavily coupled with CoT annotation quality, making large-scale training unreliable. These raise fundamental questions: Is textual CoT the optimal form of reasoning for embedding, and can effective embedding reasoning be accomplished in latent space? To this end, we propose LaME (Latent Reasoning Multimodal Embedding), which formulates embedding-oriented latent reasoning as a weakly supervised information bottleneck. LaME employs K learnable reason tokens as a fixed-capacity bottleneck, completing all reasoning within a single forward pass. The two weak supervision signals structurally decouple contrastive from autoregressive objectives and eliminate dependence on CoT annotations, while a two-stage training pipeline ensures stable convergence. Experiments on MMEB-v2 and MRMR show that LaME achieves competitive performance, surpassing some explicit CoT-based models, while delivering 60x faster inference than explicit CoT methods and 2x faster than latent baselines with throughput comparable to discriminative embedding models. Code is available at https://github.com/PeppaWu/LaME.

Peixi Wu, Biao Yang, Feipeng Ma +7

University of Science and Technology of China · 2Kuaishou Technology · 3Zhejiang University +1

Efficient Multimodal Inference Multimodal Embedding Multimodal Contrastive Learning Latent Reasoning

Jun 11, 2026cs.CV

Objects Before Words: Object-First Inductive Biases for Grounding Language in Child-View Video

Learning grounded word meaning from natural experience requires resolving two ambiguities in infant-view recordings: when the named referent appears and where it is in a cluttered frame. In SAYCam-style data, caregiver speech is sparse and weakly synchronized with egocentric video, so single-frame contrastive pairing yields noisy positives in which the intended object is absent or entangled with distractors. We propose BabyMind, an object-first bias for child-view contrastive learning under sparse, noisy supervision. BabyMind extracts candidate object embeddings using an offline mask-based region interface, links candidates across a short utterance-centered window into lightweight object files via tracking, and aligns utterances to bags of object files with a prototype-space multiple-instance contrastive objective. Track-coherence and global-object agreement regularizers stabilize learning and transfer object-file structure into the global frame embedding used at evaluation. On SAYCam-S, BabyMind improves Labeled-S 15 forced-choice accuracy by +2.6 points over CVCL and yields consistent gains on in-vocabulary out-of-distribution benchmarks. Code is available at https://github.com/sathiiii/BabyMind.

Sathira Silva, Abrham Kahsay Gebreselasie, Muhammad Umer Sheikh +3

Mohamed bin Zayed University of Artificial Intelligence, Abu Dhabi, UAE · Weizmann Institute of Science, Rehovot, Israel

Object-Centric Representation Learning Egocentric Video Understanding Vision-Language Grounding Child Language Acquisition Multimodal Contrastive Learning

Jun 8, 2026cs.SD

RespiraMFM: A Multimodal Foundation Model with Contrastive Audio-Language Alignment for Respiratory Disease Identification

Respiratory diseases remain a leading cause of global mortality, where timely and accurate diagnosis is critical to improving patient outcomes and reducing healthcare burdens. While prior work has explored audio-based models for respiratory disease detection, such unimodal approaches often suffer from limited generalizability and diagnostic precision. In this paper, we propose RespiraMFM, a Multimodal Foundation Model that integrates respiratory sounds with patient medical history and symptoms to enhance diagnostic accuracy and disease detection capabilities. We introduce an effective contrastive alignment strategy for audio-text multimodal integration, allowing the model to learn better cross-modal representations between respiratory sounds and corresponding textual clinical information. We evaluate RespiraMFM across five major respiratory diseases using seven real-world datasets in both supervised fine-tuning and zero-shot settings, achieving a 9.15% improvement in AUROC on supervised tasks and a 20.98% gain on zero-shot tasks over existing baselines. These findings underscore the potential of our framework to advance early diagnosis and improve clinical decision-making in respiratory disease management.

Shakhrul Iman Siam, Tiantian Feng, Jiankun Zhang +2

The Ohio State University · University of Southern California · University of Chicago

Healthcare Audio-Language Models Multimodal Foundation Models Multimodal Contrastive Learning Audio Classification Multimodal Learning+1

Jun 5, 2026cs.LG

A robust PPG foundation model using multimodal physiological supervision

Photoplethysmography (PPG), a non-invasive measure of changes in blood volume, is widely used in both wearable devices and clinical settings. Recent PPG foundation models either use open-source ICU datasets with pretraining paradigms that require curated data and thus complicate generalization to field-like data, or use closed-source field-like PPG data. In contrast, we propose a PPG foundation model that does not require high-quality or field-like pretraining data, and instead leverages accompanying electrocardiogram and respiratory signals in ICU datasets to select contrastive samples during pretraining. Our approach allows the model to retain and learn from noisy PPG segments, improving robustness at inference. Our model, pretrained on 3x fewer subjects than existing state-of-the-art approaches, achieves performance improvements on 14 out of 15 diverse downstream tasks, including field-like daily activity and heart rate prediction. Our results demonstrate that multimodal supervision can integrate complementary physiological information to improve the robustness of PPG foundation models and enhance their generalization to consumer-grade data.

Eloy Geenjaar, Vince Calhoun, Scott Daly +4

Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, USA · Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, USA · Dolby Laboratories, San Francisco, USA

Multimodal Robustness Multimodal Pretraining Photoplethysmography Multimodal Contrastive Learning

Jun 4, 2026cs.SD

FIGMA: Towards FIne-Grained Music retrievAl

Retrieving music using natural language descriptions has improved with contrastive audio-text models such as CLAP, but current systems remain limited to coarse semantic queries. When descriptions specify fine-grained musical attributes such as tempo, key, chord progression, or rhythmic structure, existing models often fail to retrieve the correct audio. We show that this limitation stems from the contrastive learning objective itself: despite being trained on long captions, CLAP-based models effectively utilize only the first few tokens, discarding much of the information encoded in detailed prompts. Then, we propose FIGMA (FIne-Grained Music RetrievAl), a multi-view contrastive architecture that addresses this limitation by jointly optimizing global audio-text alignment and frame-level, token-wise alignment. This design enables FIGMA to capture both high-level semantic context and fine-grained musical attributes within a unified representation space. Moreover, we formalize the task of Fine-Grained Music Retrieval and construct Fine-Grained Music Caption dataset (FGMCaps), a large-scale dataset of 380K music-caption pairs for training along with a 10K test set, both annotated with tempo, key, chord progression, beat count, as well as genre and mood. Extensive experiments demonstrate that FIGMA consistently outperforms existing CLAP-based music retrieval models across multiple music retrieval benchmarks, including out-of-domain evaluations, with relative improvements of up to 73.3%.

Nishit Anand, Ashish Seth, Sreyan Ghosh +2

University of Maryland, College Park, USA

Audio Understanding Audio-Text Retrieval Music Information Retrieval Cross-Modal Feature Matching Multimodal Contrastive Learning

Jun 3, 2026cs.CV

BRepCLIP: Contrastive Multimodal Pretraining on BRep Primitives for CAD Understanding

Learning representations of CAD models is a largely open problem. While 3D representation learning has flourished around point clouds and meshes, the native format of CAD - boundary representations BReps, which encodes exact parametric surfaces, curves, and their topology, has received little attention as a representation learning substrate. We introduce BRepCLIP, the first framework to align BRep geometry with language and image embeddings through contrastive pretraining. We model each CAD object as a sequence of face and edge tokens with separate discrete vocabularies for surface and curve geometry, augmented with spatial and semantic descriptors that capture surface types (e.g., cylindrical, torus, NURBS) and curve primitives (e.g., line, arc, B-spline). A transformer encoder aggregates these tokens into a global BRep embedding, aligned with CLIP's text and image encoders via a joint contrastive objective. BRepCLIP generates more discriminative and semantically grounded embeddings than existing point-based alternatives, improving Top-1 retrieval over OpenShape by 40.4%, 22.0%, and 23.9% on ABC, CADParser, and Automate, respectively, and improving zero-shot classification on FabWave by 15% in Top-1 score. We further demonstrate its utility as a CAD-aware similarity metric for evaluating text and image-conditioned CAD generation, establishing the importance of structure-aware pretraining for multimodal CAD understanding. Project page is available at https://muhammadusama100.github.io/BrepClip2026/

Muhammad Usama, Didier Stricker, Mohammad Sadil Khan +1

1DFKI, Germany · 2RPTU Kaiserslautern-Landau, Germany

Multimodal Pretraining Multimodal Contrastive Learning 3D VLMs

Jun 3, 2026cs.CV

Robust Scene Transfer for PointGoal Navigation via Privileged Sensor Guided Contrastive Learning

We propose a sensor-guided adaptive contrastive learning framework for visual representation learning in PointGoal navigation. During training, privileged LiDAR sensing guides the contrastive objective through a geometry-aware similarity metric and adaptive temperature scaling, encouraging visual embeddings to capture navigation-relevant structure rather than scene-specific appearance. The resulting encoder is pretrained independently, frozen, and used as the perceptual backbone for reinforcement learning, decoupling representation learning from policy optimization. We further introduce a cross-stage domain mismatch between representation pretraining and policy learning to suppress environment-specific shortcuts and promote reliance on task-relevant features. Extensive experiments in high-fidelity simulation demonstrate that our approach significantly improves policy-level scene transfer across diverse indoor and outdoor environments. At deployment, the agent relies only on monocular RGB observations together with standard task-related inputs such as goal position and proprioceptive signals, without access to LiDAR or other privileged sensors. Our method outperforms large pretrained vision models and standard contrastive baselines under severe appearance and semantic shifts. We also release a multimodal dataset to support future research on privileged-guided visual representation learning for navigation. The code is available at:

Amirhossein Zhalehmehrabi, Tiziano Tezze, Alberto Castelini +1

Robot Navigation Domain Generalization Learning Using Privileged Information Visual RL Multimodal Contrastive Learning

Jun 3, 2026cs.CV

Continual Visual and Verbal Learning Through a Child's Egocentric Input

Children learn the meanings of words from a continuous, temporally structured stream of egocentric experience. Recent work shows that neural networks can also learn word-referent mappings from a child's egocentric video recordings, but they cycle through the shuffled data for hundreds of epochs, contrasting with how children actually encounter their environment. We introduce BabyCL, a continual multimodal learning framework that processes the SAYCam dataset in a single chronological pass, combining streaming visual representation learning with an image-text contrastive objective. BabyCL combines a multi-stage temporal segmentation of the stream with a dual replay buffer that independently manages visual and multimodal histories, and it is jointly trained with three contrastive losses on a shared backbone. Under a matched optimization budget, BabyCL outperforms streaming learning baselines on the SAYCam Labeled-S 4AFC benchmark, substantially narrowing the gap to an upper bound of offline training. Ablations show that the gains are robust to the length of the online temporal segmentation window and the eviction rule of the replay buffer. Together, these results show that meaningful word-referent mappings can emerge under training conditions much closer to a child's actual experience.

Xiaoyang Jiang, Yanlai Yang, Kenneth A. Norman +2

Agentic Learning AI Lab, New York University · Department of Psychology, Princeton University

Egocentric Video Understanding Replay-Based Continual Learning Multimodal Contrastive Learning Multimodal Learning

Jun 2, 2026cs.AI

CP-Agent: Context-Aware Multimodal Reasoning for Cellular Morphological Profiling under Chemical Perturbations

Cell Painting combines multiplexed fluorescent staining, high-content imaging, and quantitative analysis to generate high-dimensional phenotypic readouts to support diverse downstream tasks such as mechanism-of-action (MoA) inference, toxicity prediction, and construction of drug-disease atlases. However, existing workflows are slow, costly and difficult to interpret. Approaches for drug screening modeling predominantly focus on molecular representation learning, while neglecting actual experimental context (e.g., cell line, dosing schedule, etc.), limiting generalization and MoA resolution. We introduce CP-Agent, an agentic multimodal large language model (MLLM) capable of generating mechanism-relevant, human-interpretable rationales for cell morphological changes under drug perturbations. At its core, CP-Agent leverages a context-aware alignment module, CP-CLIP, that jointly embeds high-content images and experimental metadata to enable robust treatment and MoA discrimination (achieving a maximum F1-score of 0.896). By integrating CP-CLIP outputs with agentic tool usage and reasoning, CP-Agent compiles rationales into a structured report to guide experimental design and hypothesis refinement. These capabilities highlight CP-Agent's potential to accelerate drug discovery by enabling more interpretable, scalable, and context-aware phenotypic screening -- streamlining iterative cycles of hypothesis generation in drug discovery.

Yuxin Zhang, Yiyao Li, Ping Shu Ho +3

Department of Electrical and Computer Engineering, The University of Hong Kong · School of Computing and Data Science, The University of Hong Kong · Nvidia AI Technology Center +2

AI Agents for Scientific Discovery Multimodal Contrastive Learning Multimodal Agents Drug Discovery