Optical Coherence Tomography

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Overview

Optical coherence tomography uses light to produce cross-sectional images of tissue, especially the retina, while OCT angiography (OCTA) reveals blood-vessel structure. Research develops CNN and Transformer methods for retinal-layer and lesion segmentation, disease classification, anomaly detection, and image reconstruction, alongside self-supervised learning, domain adaptation, and foundation models to reduce reliance on labeled scans. These tools are evaluated on tasks and datasets such as retinal-fluid segmentation, DUKE DME, OCTA-500, and OCT-Bench, and are also being applied to surgical guidance and robotic scanning. A central challenge is ensuring reliable performance across devices, hospitals, and diseases: strong benchmark scores or realistic synthetic images do not necessarily establish clinical usefulness, calibration, or safe generalization.

Latest papers

CardsList

43 papers5 papers in the last four weeks, against 2 the four weeks before. 0.0% of all new papers.

  1. CNN-Based Retinal OCT Classification: Research Gap Analysis and a From-Scratch Baseline, ED126-A

    Nov 1, 2026Shkelqim SherifiRetinal Disease ClassificationOptical Coherence Tomography

    Dept. of Computer Science, University of Tetovo, Tetove, R.N.Macedonia

  2. Low-rank MERA Decomposition of 3D OCT Image Volume for Compression, Denoising, Feature Extraction and Diagnosis of Retinal Diseases

    Oct 26, 2026Ivica Kopriva, Fei Shi, Marija Štanfel +4Optical Coherence TomographyMedical Image Representation Learning

    Ivica Kopriva is with Division of Computing and Data Science, Rudjer Boskovich Institute, Zagreb,Croatia · Fei Shi and Gaowei Li are with the School of Electronics and Information Engineering, Soochow University, Suzhou, China, and the Jiangsu Key Laboratory of Artificial Intelligence and Medical Imaging, Soochow University, Suzhou, China · Marija Štanfel is with Department of Ophthalmology, University Hospital Center Zagreb, Zagreb, Croatia +2

  3. Compression of Vision Foundation Models for Retinal OCT via Growing-Neural-Gas Codebooks and Graph-Guided Masked Image Modeling

    Oct 23, 2026Ali Yavari, Tilman Schmoll, Rainer A. Leitgeb +2Model CompressionVision Foundation Models

    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria · Carl Zeiss Meditec AG, Rudolf-Eber-Straße 11, Oberkochen, 73447, Germany

  4. A Visual Grounding Benchmark for Retinal OCT with Multimodal Large Language Models

    Oct 22, 2026Ronald Fecso, José Morano, Botond Fazekas +6Medical VLMsMedical Image Grounding

    Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Vienna, Austria · Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria

  5. International Multi-Centre Validation of Unsupervised Domain Adaptation for Precise Discrimination between Normal and Abnormal Retinal Development

    Oct 15, 2026Zhanhan Tu, Nikhil Reddy, Helen J. Kuht +27Unsupervised Domain AdaptationOptical Coherence Tomography

    The University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, RKCSB, PO Box 65, Leicester, LE2 7LX, UK · International Institute of Information Technology, Gachibowli, Hyderabad - 500 032, India · inAmind Laboratory, Department of Neuroscience, Psychology and Behaviour, University of Leicester, George Davies Centre, Lancaster Road, Leicester, LE1 7RH, UK. +11

  6. OCT-FedSIR: Toward Trustworthy Federated Ophthalmic Learning under Annotation Noise

    Sep 13, 2026Sina Gholami, Abdulmoneam Ali, Tania Haghighi +8Federated LearningNoisy-Label Learning

    Department of Electrical and Computer Engineering, University of North Carolina at Charlotte, Charlotte, NC, USA · Department of Ophthalmology, Wake Forest School of Medicine, Winston-Salem, NC, USA · Byers Eye Institute at Stanford, Stanford University School of Medicine, Stanford, CA, USA +1

  7. Predictive Multi-Landmark OCT Tracking for Increased Motion Robustness

    Sep 10, 2026Konrad Reuter, Suresh Guttikonda, Chaitali Uday Karekar +2Point TrackingObject Pose Estimation

    Department of Otorhinolaryngology, Head and Neck Surgery and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

  8. OCTN: Neural OCT Representations for Robot-Guided Precision Intervention

    Sep 6, 2026Ravi Prakash, Ryan P. McNabb, Patrick J. Codd +1Optical Coherence TomographyImplicit Neural Representations

    Duke University, Durham, NC 27705 USA · Arizona State University, Phoenix, AZ 85287 USA

  9. Retinal OCTA Phenotyping with LLM Reporting for Alzheimer's Disease

    Sep 4, 2026Progga Paromita Dutta, Jeba Maliha, Md Rafiul KabirExplainable Medical Image AnalysisOptical Coherence Tomography

    Department of Computer Science, Columbia University, New York, NY, USA · School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, USA

  10. ARCOS: Zero-shot Boundary Localization for Corneal Layer Segmentation Across Optical Coherence Tomography Devices

    Sep 3, 2026Nuno Vivas Brás, Benjamin Memmi, Maëlle Bouhassane +4Domain GeneralizationOptical Coherence Tomography

    Laboratoire d’Optique et Biosciences, CNRS, INSERM, ´Ecole polytechnique, Institut Polytechnique de Paris, Palaiseau, France · GRC 32, Transplantation et Th´erapies Innovantes de la Corn´ee, Sorbonne Universit´e, Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, Paris, France

  11. Automated 2D and 3D Segmentation of AMD and DME Lesions in OCT

    Aug 27, 2026Lucia Sundberg, Zhihao Zhao, M. Ali NasseriOphthalmic Image AnalysisMedical Image Segmentation

    MAPS Lab, Technical University of Munich, Munich, Germany. · University of Wisconsin-Madison, Madison, Wisconsin, USA.

  12. When the Edit Changes the Patient: Measuring Identity Preservation in Counterfactual Retinal Images

    Aug 24, 2026Andrea Posada, Wenke Karbole, Bach Ngoc Doan +9Counterfactual Image GenerationIdentity-Preserving Image Generation

    Technical University of Munich and TUM University Hospital, Germany · Munich Center of Machine Learning (MCML), Munich, Germany · Munich Data Science Institute (MDSI), Munich, Germany +4

  13. RetiWave-Mamba: A Dual-Stream Network for Retinal Disease Detection based on Multi-scale Context and Feature-Adaptive Mamba Projection

    Aug 18, 2026Cheng Cheng, Jin HongRetinal Disease ClassificationMedical Image Classification

    School of Artificial Intelligence, Nanchang University, Nanchang 330031, China · School of Information Engineering, Nanchang University, Nanchang 330031, China

  14. In Defense of OCTA: The Reconstruction-Utility Gap in OCT-to-OCTA Synthesis

    Aug 16, 2026Michael Chertok, Alon Tiosano, Orly Gal-Or +4Medical Image SynthesisOptical Coherence Tomography

    MarkerLeap, Raanana, Israel · Rabin Medical Center, Petah Tikva, Israel · Tel Aviv University, Tel Aviv, Israel

  15. TRIAGE: Risk-Controlled Pseudo-Label Admission for Annotation-Efficient Semi-Supervised Retinal OCT Classification

    Aug 14, 2026Md Ashraful Hossen Akash, Shyla Afroge, Abdullah Al Mamun +2Medical Image ClassificationRetinal Disease Classification

    Department of Computer Science & Engineering, Rajshahi University of Engineering & Technology, Rajshahi-6204, Bangladesh · Elite Research Lab LLC, New York, USA · Faculty of Information Science and Technology, Multimedia University, Melaka, Malaysia +1

  16. Label-Free Deep-Tissue Peripheral Nerve Detection with a Handheld Multimodal OCT Probe and NerveDetNet

    Aug 13, 2026Yihan Wang, Ruilin You, Shaobai Li +4Medical ImagingMedical Image Segmentation

    Wyant College of Optical Sciences, University of Arizona, Tucson, Arizona 85721, USA · Department of Oral & Maxillofacial Surgery, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA

  17. Algorithmic statistics of retinal images

    Aug 6, 2026Loan Huynh, Ronald Zambrano, Layton Aho +4Medical ImagingLongitudinal Medical Image Analysis

    Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA, USA · Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA · School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA +2

  18. DualDiT: A Conditional Dual-Output Diffusion Transformer for Joint OCT Image and Segmentation Mask Generation

    Jul 31, 2026Fernando García-Torres, Rocío del Amor, Sandra Morales +4Synthetic Data AugmentationDiffusion Transformer

    Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano (HUMAN-tech), Universitat Politècnica de València, Camino de Vera, s/n, Valencia, 46022, Comunidad Valenciana, Spain · Artikode Intelligence S.L, Camino de Vera, s/n, Valencia, 46022, Comunidad Valenciana, Spain · Biomedical Technology Center of the Medical Faculty, University of Muenster, Mendelstraße 17, Münster, 48149, North Rhine-Westphalia, Germany +1

  19. ReMoE: Report-Guided Mixture-of-Experts for Multimodal OCT/OCTA Anomaly Detection

    Jul 31, 2026Zihan Nie, Qincheng Qiao, Muhao Xu +4Mixture of ExpertsOptical Coherence Tomography

    School of Mechanical Engineering, Shandong University, Jinan, China · 2Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Shandong University, Ministry of Education, Jinan, China · 6Airdoc-Monash Research, Monash University, Clayton, VIC 3800, Australia +3

  20. PC-Seg: Progressive Cross-View Consistency for 3D OCT Segmentation from Sparse 2D Annotations

    Jul 20, 2026Tsubasa Konno, Takahiro Ninomiya, Yukun Zhou +6Multi-View ConsistencyOptical Coherence Tomography

    Graduate School of Information Sciences, Tohoku University, Japan · Department of Ophthalmology, Graduate School of Medicine, Tohoku University · Institute of Ophthalmology, University College London, UK +3

  21. Can Multimodal Large Language Models Understand OCT?

    Jul 18, 2026Baochen Fu, Wenzhi Deng, Baihao Jin +5Medical Image BenchmarksMedical Imaging

    1Shandong University · 4Shandong Provincial Qianfoshan Hospital · University of Science and Technology of China +2

  22. Spatial Normalization for Cross-Domain Retinal Layer Segmentation in Optical Coherence Tomography

    Jul 17, 2026Iker Moran-Cavero, Monica Hernandez, Elvira Mayordomo +4Medical ImagingOptical Coherence Tomography

  23. Uncertainty-Aware Multi-Source Retinal Fluid Segmentation in OCT

    Jul 9, 2026Animesh KumarDomain AdaptationMedical Imaging

    Newcastle University, Newcastle upon Tyne NE1 7RU, United Kingdom

  24. Calibrated Hybrid CNN-Transformer for Retinal OCT Classification

    Jul 9, 2026Animesh KumarUncertainty QuantificationOptical Coherence Tomography

    School of Computing, Newcastle University, UK

  25. Cross-Modal Fusion of OCT and OCT angiography enface for Improved Diagnostics of Diabetic Retinopathy

    Jul 4, 2026Rashadul Hasan Badhon, Atalie Carina Thompson, Jennifer I. Lim +2Diabetic Retinopathy GradingOptical Coherence Tomography

  26. Fully Automated High-Precision Segmentation of Retinal Atrophy and Ellipsoid Zone Thickness in OCT: A Reliable Tool for Real-World GA Monitoring

    Jun 30, 2026Wolf-Dieter Vogl, Hlynur Skulason, Oliver Leingang +3Medical ImagingOptical Coherence Tomography

    RetInSight GmbH, Vienna, Austria · Laboratory of Opthalmic Image Analysis (OPTIMA), Medical University of Vienna, Austria

  27. Test-Time Adaptation in Optical Coherence Tomography Using Trajectory-Aligned Time-Independent Flow

    Jun 17, 2026Veit Hucke, Thomas Pinetz, Gregor Reiter +2Image DenoisingMedical Imaging

    Institute of Artificial Intelligence, Center for Medical Data Science, Medical University of Vienna, Austria · Comprehensive Center for Artificial Intelligence in Medicine, Medical University of Vienna, Austria · Department of Ophthalmology and Optometry, Medical University of Vienna, Austria +1

  28. Deep Learning-assisted AMD Staging based on OCT and OCT Angiography

    Jun 3, 2026Yukun Guo, Tristan T. Hormel, An-Lun Wu +4Medical ImagingOptical Coherence Tomography

    Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA · Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA · Department of Ophthalmology, Mackay Memorial Hospital, Hsinchu 300044, Taiwan

  29. Three-Dimensional Retinal Microvasculature Restoration in OCT Angiography

    Jun 3, 2026Yukun Guo, Min Gao, Tristan T. Hormel +3Medical Imaging3D Medical Imaging

    Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239, USA · Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA

  30. Gaze into the Details: Locality-Sensitive Enhancement for OCTA Retinal Vessel Segmentation

    May 20, 2026Tuopusen Huang, Ding Ma, Xiangqian WuMedical ImagingRetinal Vessel Segmentation

    Faculty of Computing Harbin Institute of Technology Harbin, China