Unsupervised Domain Adaptation

Labeling medical images is a major bottleneck in the field of medical imaging, as it requires domain-specific expertise, and it gets further complicated due to variability across different medical centers and different imaging devices. Such heterogeneity introduces domain shifts and modality discrepancies, which limits the generalization of trained models. To address this important challenge, we propose an unsupervised domain adaptation framework that combines transfer learning with a Reproducing Kernel Hilbert Space based Maximum Mean Discrepancy loss for the alignment of source and target domains. By jointly optimizing classification and RKHS-MMD losses, the methodology enhances generalization to unannotated medical datasets while diminishing reliance on manual annotation. Experimental evaluations presented on two chest X-ray datasets, which are obtained from different medical centers, show outstanding improvements over models trained without adaptation. Furthermore, we perform a comparative study to see that RKHS-MMD performs better than the standard Maximum Mean Discrepancy in reducing modality gap, emphasizing its effectiveness for medical image classification and also its strong capability in advanced AI-driven medical diagnostics.

The clinical integration of deep learning models for brain tumor diagnosis in neuro-oncology is severely constrained by limited expert-annotated MRI data and substantial inter-institutional domain shift arising from variations in scanners, imaging protocols, and contrast settings. These challenges significantly impair model generalization in real-world settings. To address this, we propose a novel orientation-aware unsupervised domain-adaptive framework for automated brain tumor classification using mixed 2D MRI slices. Initially, a CNN with large receptive field first categorizes input slices into axial, sagittal, and coronal views. For each orientation, a CNN architecture with ResNet50 backbone augmented with four fully connected layers is trained to extract discriminative features for tumor classification. To mitigate annotation scarcity and domain discrepancies, we introduce a slice-wise unsupervised domain adaptation strategy that transfers knowledge from the multi-modal such as T1, T2, and FLAIR source domain to the post-contrast T1 target domain. Feature-level alignment is enforced using maximum mean discrepancy loss, complemented by pseudo-label guided adaptation to preserve class discriminability. Extensive experiments demonstrate improved target-domain performance over prior approaches, highlighting the benefits of orientation-specific learning, multi-modal knowledge transfer, pseudo-label-guided adaptation, and unsupervised domain adaptation.

Cross-scene hyperspectral image (HSI) classification stands as a fundamental research topic in remote sensing, with extensive applications spanning various fields. Owing to the inclusion of unknown categories in the target domain and the existence of domain shift across different scenes, open-set domain adaptation techniques are commonly employed to address cross-scene HSI classification. However, existing open-set cross-scene HSI classification methods still face two critical challenges: (1) domain shift issues arising from the direct alignment of mixed spectral-spatial features; (2) high computational costs caused by two-stage training strategies. To address these issues, this paper proposes a single-stage open-set domain adaptation method with decoupled alignment (SoDa$^2$) for cross-scene HSI classification. A contribution-aware dual-modality feature extraction is customized to disentangle the characteristics from spectral sequence signals and spatial details, selectively and adaptively enhancing discriminative features. The decoupled alignment module minimizes the Maximum Mean Discrepancy to independently reduce the spectral discrepancy and the spatial discrepancy between the source and target domains, extracting more fine-grained domain-invariant features. A cost-effective single-stage dual-branch framework is designed to learn MMD-constrainted aligned features and constraint-free intrinsic features for adaptive distinction between known and unknown classes. This framework employs a Gaussian Mixture Model to model the squared cosine similarity distribution between the two feature types, enabling open-set recognition without prior knowledge of unknown classes. Extensive experiments on three groups of HSI datasets demonstrate that SoDa$^2$ outperforms state-of-the-art methods, achieving superior classification accuracy and model transferability for open-set cross-scene tasks.

Semantic segmentation provides pixel-level scene understanding essential for autonomous driving and fine-grained perception tasks. However, training segmentation models requires costly, labor-intensive annotations on real-world datasets. Unsupervised Domain Adaptation (UDA) addresses this by training models on labeled synthetic data and adapting them to unlabeled real images. While conceptually simple, adaptation is challenging due to the domain gap, i.e., differences in visual appearance and scene structure between synthetic and real data. Prior approaches bridge this gap through pixel-level mixing or feature-level contrastive learning. Yet, these techniques suffer from two major limitations: (1) reliance on high-confidence pseudo-labels restricts learning to a subset of the target domain, and (2) prototype-based contrastive methods initialize class prototypes from source-trained models, yielding biased and unstable anchors during adaptation. To address these issues, we propose a dual-foundation UDA framework that leverages two complementary foundation models. First, we employ the Segment Anything Model (SAM) with superpixel-guided prompting to enable learning from a broader range of target pixels beyond high-confidence predictions. Second, we incorporate DINOv3 to construct stable, domain-invariant class prototypes through its robust representation learning. Our method achieves consistent improvements of +1.3% and +1.4% mIoU over strong UDA baselines on GTA-to-Cityscapes and SYNTHIA-to-Cityscapes, respectively.

Mapping standing dead trees is crucial for acquiring information on the effects of climate change on forests and forest biodiversity. However, leveraging high-quality aerial imagery for dead tree segmentation poses challenges due to limitations in sensor availability and the scarcity of annotated data. In this study, we propose a generic blind super-resolution framework that incorporates Attention-Guided Domain Adaptation Networks (ADA-Nets) to learn the mapping from low-resolution to high-resolution multispectral image domains. Our approach operates solely on unpaired samples, mimicking real-world conditions, i.e., low-resolution images are not synthetically obtained by downsampling the high-resolution images. Moreover, the proposed method serves as a general-purpose restorer addressing several image degradation types, including saturation, noise, and low contrast that typically occur in low-resolution images acquired by low-end sensors. To the best of our knowledge, this is the first study to perform real-world and generic super-resolution for multispectral data in the scope of standing dead tree segmentation. Experimental evaluations demonstrate segmentation performances of 54% and 64% in Dice scores. Notably, the first result is obtained without using any high-resolution annotations; the segmentation network is trained on super-resolved low-resolution images, while evaluation is performed on the high-resolution data. We publicly share the aerial multispectral dataset with manually annotated labels at https://www.kaggle.com/datasets/meteahishali/aerial-imagery-for-dead-tree-segmentation-poland.

We propose HeroCrystal, a novel privacy-preserving framework for multi-camera domain-adaptive object detection, addressing challenges such as data privacy, class imbalance, and heterogeneous architectures. Our framework consists of three key stages. In the Generated Stage, we introduce a one-shot, target-aware diffusion-based generation module that learns visual style from a single target-domain image while leveraging prompt-based control to synthesize specific object instances. Unlike conventional style transfer-based methods that require large target datasets and ignore semantic-level discrepancies, our approach enables privacy-preserving augmentation to reduce ethical concerns, and introduces controllable rare object generation to mitigate long-tailed category degradation. In the Federated Stage, we employ probabilistic Faster R-CNN on the client side to improve localization accuracy, and a dynamic model contrastive strategy to suppress domain-specific bias. The server side performs model fusion across heterogeneous architectures without accessing raw data. Finally, in the Distilled Stage, we propose an inconsistent categories integration algorithm to resolve label inconsistency and architecture heterogeneity across clients. Extensive experiments on multiple cross-domain detection benchmarks demonstrate that our method outperforms existing multi-source domain adaptation and federated learning baselines under multi-class, privacy-preserving settings. Our method improves mAP by +2.1% over prior privacy-preserving approaches and achieves a new state-of-the-art mAP of 33.4%, highlighting the effectiveness of HeroCrystal in enabling practical multi-camera AI surveillance systems. The source code is publicly available at https://github.com/ccuvislab/HeroCrystal.

The performance of state-of-the-art object detectors degrades significantly under adverse weather, causing a safety-critical domain shift problem for autonomous vehicles. Recent efforts address this problem by relying on synthetic data to train the object detectors, which limits their real-world applicability. Meanwhile, pseudo-labeling is widely used for cross-dataset domain adaptation problems. However, these methods have not been exploited by weather-based domain adaptation approaches due to the noisy nature of such labels generated under harsh weather conditions. In this paper, we propose two new approaches to mitigate this weather-induced domain shift. First, we propose a Weather-Induced pseudo Label Denoising (WILD) framework that filters noisy pseudo labels generated by real data captured under adverse weather conditions. Second, we develop a novel hybrid training methodology, WILD SAM, that exploits both pseudo-label denoising and simulation-based training solutions while using real-data from the target harsh-weather domain. We validate both proposed approaches, WILD and WILD SAM, on the recently released Four Seasons dataset across rainy and snowy scenarios. Experiments show that the proposed frameworks improve Average Precision (AP) up to 13% and significantly reduce the weather-induced performance gap relative to the baseline. The code is available at: https://github.com/Kh-Hamed/WILD-SAM

Domain adaptation (DA) addresses the challenge of transferring a machine learning model trained on a source domain to a target domain with a different data distribution. In this work, we study DA for the task of Rumex obtusifolius (Rumex) image classification. We train models on a published, ground vehicle-based dataset (source) and evaluate their performance on a custom target dataset acquired by unmanned aerial vehicles (UAVs). We find that Convolutional Neural Network (CNN) models, specifically ResNets, generalize poorly to the target domain, even after fine-tuning on the source data. Applying moment-matching and maximum classifier discrepancy, two established DA techniques, substantially improves target-domain performance. However, Vision Transformer (ViT) models pretrained with self-supervised objectives (DINOv2, DINOv3) handle domain shifts intrinsically well, surpassing even moment-matching-trained ResNets, likely due to the rich, general-purpose representations acquired during large-scale pretraining. Using ViTs fine-tuned on the source dataset, we demonstrate high classification performances in the range of F1=0.8 on our target dataset. To support further research on DA for weed detection in grassland systems, we publicly release our UAV-based target dataset AGSMultiRumex, comprising data from 15 flights over Swiss meadows.

Unsupervised domain adaptation generalizes neural retrievers to an unseen domain by generating pseudo queries on target domain documents. The quality and efficiency of this adaptation critically depend on which documents are selected for pseudo query generation. The existing document sampling method focuses on diversity but fails to capture model uncertainty. In contrast, we propose Uncertainty-based Iterative Document Sampling (UnIte) addressing these limitations by (1) filtering documents with high aleatoric uncertainty and (2) prioritizing those with high epistemic uncertainty, maximizing the learning utility of the current model. We conducted extensive experiments on a large corpus of BEIR with small and large models, showing significant gains of +2.45 and +3.49 nDCG@10 with a smaller training sample size, 4k on average.

The second-order harmonic (2f) component generated by twin-rotary compressor is a dominant low-frequency noise source of variable refrigerant flow (VRF) outdoor units, yet its amplitude fluctuates strongly with environmental thermal load and valve opening, making it difficult to assess accurately using conventional mechanism-based models. This paper proposes an unsupervised transfer learning method based on Domain-invariant Partial Least Squares (Di-PLS) to accurately predict 2f noise levels under new conditions using different signals. Prediction models utilizing thermodynamic signals and acceleration signals are constructed respectively, and the generalization performance of the proposed Di-PLS is systematically compared with traditional Partial Least Squares (PLS). Results demonstrate that Di-PLS significantly outperforms PLS by extracting cross-condition common features and minimizing the distribution discrepancy between the source and target domains. Specifically, the acceleration-based Di-PLS model achieves the best performance, maintaining prediction errors within 3 dB for all test cases. This superiority over thermodynamic-based models highlights a physical insight: while thermodynamic states drive dynamic changes, structural vibration possesses a stronger and more direct causal link to acoustic radiation.

A central problem in unsupervised domain adaptation is determining what to transfer from labeled source domains to an unlabeled target domain. To handle high-dimensional observations (e.g., images), a line of approaches use deep learning to learn latent representations of the observations, which facilitate knowledge transfer in the latent space. However, existing approaches often rely on restrictive assumptions to establish identifiability of the joint distribution in the target domain, such as independent latent variables or invariant label distributions, limiting their real-world applicability. In this work, we propose a general domain adaptation framework that learns compact latent representations to capture distribution shifts relative to the prediction task and address the fundamental question of what representations should be learned and transferred. Notably, we first demonstrate that learning representations based on all the predictive information, i.e., the label's Markov blanket in terms of the learned representations, is often underspecified in general settings. Instead, we show that, interestingly, general domain adaptation can be achieved by partitioning the representations of Markov blanket into those of the label's parents, children, and spouses. Moreover, its identifiability guarantee can be established. Building on these theoretical insights, we develop a practical, nonparametric approach for domain adaptation in a general setting, which can handle different types of distribution shifts.

Transthoracic echocardiography is the reference standard for confirming structural heart disease (SHD), but first-line screening is limited by cost, workflow burden, and specialist availability. We evaluated whether open pretrained electrocardiogram (ECG) foundation models can support echo-confirmed multi-label SHD detection using the public EchoNext Mini-Model benchmark. Six echocardiography-derived abnormalities were targeted: reduced left ventricular ejection fraction, increased left ventricular wall thickness, aortic stenosis, mitral regurgitation, tricuspid regurgitation, and right ventricular systolic dysfunction. Under a common pipeline, we compared engineered ECG features with gradient boosting, end-to-end waveform learning from scratch, and transfer from open ECG foundation models. We then applied in-domain self-supervised adaptation of an ECG foundation model (ECG-FM) on EchoNext waveforms followed by selective supervised fine-tuning, and evaluated trade-offs between discrimination and adaptation cost. Adapted ECG-FM models achieved the best overall performance: peak macro-AUROC 0.8509 and macro-AUPRC 0.4297, while a parameter-efficient operating point preserved AUROC (0.8501) and attained the highest fixed-threshold macro-F1 0.3691. Late fusion with covariates did not improve threshold-independent discrimination, and evaluated LoRA, alternative backbones, and mixture-of-foundations strategies did not surpass the best adapted single-backbone models. These results indicate that for ECG-based case finding and echocardiography triage, combining target-domain self-supervised adaptation with selective supervised updating of a pretrained ECG backbone is the most effective transfer strategy.

This paper presents the first study on Unsupervised Domain Adaptation (UDA) for multimodal 3D panoptic segmentation (mm-3DPS), aiming to improve generalization under domain shifts commonly encountered in real-world autonomous driving. A straightforward solution is to employ a pseudo-labeling strategy, which is widely used in UDA to generate supervision for unlabeled target data, combined with an mm-3DPS backbone. However, existing supervised mm-3DPS methods rely heavily on strong cross-modal complementarity between LiDAR and RGB inputs, making them fragile under domain shifts where one modality degrades (e.g., poor lighting or adverse weather). Moreover, conventional pseudo-labeling typically retains only high-confidence regions, leading to fragmented masks and incomplete object supervision, which are issues particularly detrimental to panoptic segmentation. To address these challenges, we propose PanDA, the first UDA framework specifically designed for multimodal 3D panoptic segmentation. To improve robustness against single-sensor degradation, we introduce an asymmetric multimodal augmentation that selectively drops regions to simulate domain shifts and improve robust representation learning. To enhance pseudo-label completeness and reliability, we further develop a dual-expert pseudo-label refinement module that extracts domain-invariant priors from both 2D and 3D modalities. Extensive experiments across diverse domain shifts, spanning time, weather, location, and sensor variations, significantly surpass state-of-the-art UDA baselines for 3D semantic segmentation.

We present RoIt-XMASA, a multilingual dataset that extends the Cross-lingual Multi-domain Amazon Sentiment Analysis to Italian and Romanian, comprising 36,000 labeled reviews across three domains (books, movies, and music) and 202,141 unlabeled samples. To address cross-lingual and cross-domain challenges, we propose a multi-target adversarial training framework that employs loss reversal with meta-learned coefficients to dynamically balance sentiment discrimination with domain and language invariance. XLM-R achieves an F1-score of 66.23% with our approach, outperforming the baseline by 4.64%. Few-shot evaluation shows that Llama-3.1-8B achieves 58.43% F1-score, revealing a meaningful trade-off between the efficiency of prompting-based approaches and the higher performance of task-specific fine-tuning.

Large Language Models (LLMs) generalize across tasks through reusable representations and flexible reasoning, yet remain brittle in real deployment when faced with evolving tasks and continual distribution shift. While test-time adaptation addresses this by updating models with unsupervised objectives on test data, prevailing methods are fundamentally limited by their neglect of source knowledge preservation and adaptation signal reliability. Inspired by how Drosophila orchestrates memory update by balancing retroactive and proactive interference via Rac1 and MAPK pathways, we design Synapse Consolidation (SyCo) with two core components: a Rac1-inspired plasticity confiner and a MAPK-inspired update controller. The former dynamically confines plasticity to a tail-gradient subspace that is less critical for source knowledge, enabling rapid specialization while preserving source representations. The latter uses a tiered controller to suppress noisy updates and consolidate useful adaptations under non-stationary streams. To further model real deployments with multiple sources and continually emerging tasks, we introduce Multi-source Open-set Adaptation (MOA) setting, where a model is trained on multiple labeled source tasks and then adapts on open, non-stationary unlabeled test streams mixing seen and unseen tasks with partial overlap in label and intent space. Across 18 NLP datasets under the MOA setting, SyCo consistently outperforms strong baselines, achieving 78.31% on unseen-task adaptation and 85.37% versus unseen-data shifts, setting a new state-of-the-art.

Out-of-domain (OOD) robustness is challenging to achieve in real-world computer vision, especially in unsupervised domain adaptation scenarios, where shifts in image background, style, and acquisition instruments often degrade model performance. Generic augmentations show inconsistent gains under such shifts, whereas dataset-specific augmentations require expert knowledge and prior analysis. Moreover, prior studies show that neural networks adapt poorly to domain shifts because they exhibit a learning bias to domain-specific frequency components. Perturbing frequency values can mitigate such bias but overlooks pixel-level details, leading to suboptimal performance. To address these limitations, we propose D-GAP, a Dataset-agnostic and Gradient-guided augmentation method for the Amplitude spectrum (in frequency space) and the Pixel values. Unlike conventional handcrafted augmentations, D-GAP computes sensitivity maps in the frequency space from task gradients, which reflect how strongly the deep models respond to different frequency components, and uses the maps to adaptively interpolate amplitudes between source and target samples. We further propose a dual-space augmentation that jointly controls spectral bias and spatial fidelity by introducing a complementary pixel-space blending branch. This way, D-GAP turns augmentation from fixed, random, or manually designed perturbation into a model-response-adaptive intervention. Extensive experimental results show that the proposed method consistently outperforms both generic and dataset-specific domain adaptation methods, improving average OOD performance by +5.3% on four real-world datasets and +1.9% on three benchmark datasets. Code is available at https://github.com/RapidsAtHKUST/D-GAP.

Robust medical image segmentation across modalities remains challenging due to severe domain shifts and the lack of target-domain labels. While diffusion models have been explored for cross-domain generation and augmentation, target-domain conditional diffusion training typically relies on highly noisy pseudo masks; naively conditioning on a single Arg-Max pseudo-label can corrupt diffusion training and downstream segmentation. We propose UPDiff-UDA, a unified UDA framework whose core is an uncertainty-guided training objective for target-domain conditional diffusion. Given an imperfect source-trained segmenter, we use its per-pixel softmax distribution to form ranked pseudo-label maps (Arg-Max, Arg-2nd, Arg-3rd, ...). Each map yields a conditional score estimate, and we aggregate them via pixel-wise confidence weighting to obtain an uncertainty-reweighted score for score matching, improving robustness to pseudo-label noise while leveraging alternative plausible labels in uncertain regions. We further provide a theoretical justification showing that confidence-weighted aggregation follows a minimum-MSE convex-combination principle under the segmenter-induced surrogate label distribution. To improve pseudo-condition quality, we also introduce a feature-guided, low-degree-of-freedom Bézier curve adaptation to reduce appearance gaps. Experiments on multiple public datasets and modality shifts show that UPDiff-UDA generates high-fidelity labeled target-style samples for augmentation and consistently outperforms strong UDA baselines. The code for this project is available at: https://github.com/superlc1995/Multi-Channel-Uncertainty-Diffusion-UDA

Unsupervised domain adaptation (UDA) effectively bridges the domain gap between a labeled source domain and an unlabeled target domain, but assumes that the two domains share the same modality. Heterogeneous domain adaptation (HDA) instead handles different feature spaces across domains, yet requires labeled target samples or paired data linking the source and target domains. Neither applies when a labeled source domain and a fully unlabeled target domain each hold an entirely distinct modality (e.g., 2D images and 3D point clouds). To address this limitation, we introduce a new setting termed Heterogeneous-Modal Unsupervised Domain Adaptation (HMUDA), which transfers knowledge across modalities via an unlabeled bridge domain containing paired observations from both modalities, whose distribution may deviate from those of the source and target domains. To learn under the HMUDA setting, we propose Latent Space Bridging (LSB), a dual-branch framework where a feature consistency loss on paired bridge samples closes the modality gap and a class-centroid alignment loss reduces the source-target discrepancy. Extensive experiments on eight benchmark settings covering both 2D-to-3D and 3D-to-2D transfer demonstrate that LSB achieves state-of-the-art performance.

Prompt tuning has become a key mechanism for adapting pre-trained Graph Neural Networks (GNNs) to new downstream tasks. However, existing approaches are predominantly supervised, relying on labeled data to optimize the prompting parameters and typically fine-tuning a task-specific prediction head -- practices that undermine the promise of parameter-efficient adaptation. We propose Unsupervised Graph Prompting Problem (UGPP), a challenging new setting where the pre-trained GNN is kept entirely frozen, labels on the target domain are unavailable, the source data is inaccessible, and the target distribution exhibits covariate shift. To address this, we propose UGPrompt, the first fully unsupervised GNN prompting framework. UGPrompt leverages consistency regularization and pseudo-labeling to train a prompting function, complemented with diversity and domain regularization to mitigate class imbalance and distribution mismatch. Our extensive experiments demonstrate that UGPrompt consistently outperforms state-of-the-art supervised prompting methods with access to labeled data, demonstrating the viability of unsupervised prompting as a practical adaptation paradigm for GNNs.

Autonomous systems (AS) often rely on Deep Neural Network (DNN) classifiers to operate in complex and dynamically changing environments. However, during operation, these classifiers may encounter domains that differ from those seen during development, causing performance degradation under distribution shift. Removing systems from operation for labelled data collection and retraining is often impractical, particularly when adaptation must occur quickly and at scale. This paper introduces DIRA-SS, a self-supervised extension of Dynamic Incremental Regularised Adaptation (DIRA) that enables online domain adaptation using only a small number of unlabelled target-domain samples. DIRA-SS augments an existing classifier with an auxiliary retraining branch and adapts the shared feature representation through a rotation-prediction task, while elastic weight consolidation regularises important source-domain parameters to reduce destructive updates. This allows the model to benefit from transfer learning without requiring classification labels during operation. We evaluate DIRA-SS on CIFAR-10C, CIFAR-100C, and ImageNet-C using ResNet architectures under severe common corruptions. The results show that DIRA-SS substantially improves performance over the non-adapted source model, achieves accuracy close to the supervised DIRA method, and outperforms existing unsupervised test-time adaptation baselines on ImageNet-C when using only 100 target-domain samples.

Dense prediction tasks in surgical computer vision, such as segmentation and surgical zone prediction, can provide valuable guidance for laparoscopic and robotic surgery. However, these models often suffer from distribution shifts, as training datasets rarely cover the variability encountered during deployment, leading to poor generalization. We propose DenseTRF, a self-supervised representation adaptation framework based on texture-centric attention. Our method leverages slot attention to learn texture-aware representations that capture invariant visual structures. By adapting these representations to the target distribution without supervision, DenseTRF significantly improves robustness to domain shifts. The framework is implemented through conditioning dense prediction on slot attention and model merging strategies. Experiments across multiple surgical procedures demonstrate improved cross-distribution generalization in comparison to state-of-the-art segmentation models and test-distribution adaptation methods for dense prediction tasks.