Scientific Hypothesis Generation

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9 papers in the last four weeks, up 125% on the four weeks before. 0.1% of all new papers.

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  1. Explore, Then Commit: Measurement-Efficient Scientific Law Discovery with Language Models

    Oct 6, 2026Kautik Mandve, Dileepa FernandoScientific DiscoveryScientific Hypothesis Generation

    Vernon Hills High School, Vernon Hills, Illinois, USA · Information Systems Technology and Design Singapore University of Technology and Design, Singapore

  2. From Scientific Observations to Mechanisms: Benchmarking Hypothesis Generation by AI Scientists

    Oct 4, 2026Xiaxun Xie, Qingqing Long, Meng Xiao +4AI Agents for Scientific DiscoveryScientific Hypothesis Generation

    Computer Network Information Center, Chinese Academy of Sciences · National University of Singapore · Sichuan University

  3. Reinforcing Agentic Creativity in Scientific Ideation with Night Science

    Sep 28, 2026Priyanka Kargupta, Silviu Cucerzan, Shweti Mahajan +4AI Agents for Scientific DiscoveryScientific Hypothesis Generation

    University of Illinois Urbana-Champaign · Microsoft · Microsoft Research

  4. DISCERN: Can AI Agents Work Like Scientists and Guide Discovery?

    Sep 27, 2026Nan Huang, Mario Tapia-Pacheco, Kun Zhou +4AI Agent ReliabilityScientific Hypothesis Generation

    University of California San Diego · Independent Researcher

  5. Learning to Ideate for Scientific Impact

    Sep 24, 2026Shubham Kale, Aniketh Garikaparthi, Manasi PatwardhanScientific Hypothesis GenerationLarge Language Model-Guided Scientific Discovery

    TCS Research, India.

  6. ScientistTwo: Pioneering the Human Knowledge Frontier with Autonomous AI

    Sep 17, 2026Jaehyun Nam, Jinsung Yoon, Yanzhou Pan +4Scientific Hypothesis GenerationMulti-Agent Systems

    Google Cloud AI Research · University of Waterloo

  7. HypoEvolve: Genetic Algorithms Enable Multi-Agent LLMs to Discover Scientific Hypotheses

    Sep 14, 2026Jieyuan Liu, Mengzhou Hu, Jefferson Chen +10Multi-Agent LLM SystemsScientific Hypothesis Generation

    University of California San Diego · 2Texas A&M University · 3Carnegie Mellon University +1

  8. HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledge

    Sep 14, 2026Dominic Okonkwo, Adetayo Okunoye, Ismailcem Budak ArpinarLLM Reasoning with GraphsEvidence-Grounded Reasoning

    School of Computing University of Georgia

  9. Measuring the Creativity of Frontier LLMs in Automated Research

    Sep 12, 2026Yiheng Zhao, Mengzhuo Chen, Chengming Hu +3Creativity AssessmentLLM Evaluation

    Concordia University, Montreal, Canada · Independent Researcher · Mcgill University, Montreal, Canada +2

  10. AgentIdeaBench: Benchmarking Scientific Ideation in the Agent Era

    Sep 7, 2026Yunxiang Mo, Tianshi Zheng, Yisen Gao +7AI for ScienceAI Agent Evaluation

    Department of Computer Science and Engineering, HKUST, Hong Kong SAR, China · NVIDIA AI Technology Center (NVAITC), NVIDIA, Santa Clara, USA

  11. HyGRAIL: Cost-Aware and Evidence-Grounded Scientific Hypothesis Discovery over Knowledge Graphs

    Sep 2, 2026Yihang Sun, Zhihan Zhu, Zhiyuan Jiang +3LLM GroundingScientific Hypothesis Generation

    University of Illinois Urbana-Champaign

  12. Can LLMs Discover Scientific Laws in Real and Parallel Worlds?

    Sep 1, 2026Yiming Huang, Ziche Liu, Junxia Cui +11Scientific DiscoveryScientific Hypothesis Generation

    University of California San Diego · University of California, Irvine · Cushing Academy +1

  13. A Human-AI Theorem Connecting Spontaneous and Field-Induced Mechanisms of Collective Behavior in One Dimension

    Aug 31, 2026Weiguo YinAI-Assisted Scientific ResearchScientific Hypothesis Generation

    Condensed Matter Physics and Materials Science Division, Brookhaven National Laboratory, Upton, New York 11973, USA

  14. AutoResearch: Insight In, Hallucination Out

    Aug 18, 2026Xiang Liu, Qumeng Sun, Bruno +3Scientific Hypothesis GenerationResearch Idea Generation

    Infinite Evolution Lab, EvoMap

  15. Visualizing Graph-to-Answer Mechanism Recovery in Materials-Science Hypothesis Generation

    Aug 4, 2026Shashwat Sourav, Subhadeep Pal, Markus J. Buehler +4LLM Reasoning with GraphsScientific Hypothesis Generation

    Department of Physics, Washington University in St. Louis · Oak Ridge National Laboratory · Lawrence Berkeley National Laboratory +6

  16. Adversarial Fast-Moving Real-World Domains as Test Beds for Benchmarking AI Scientist Capabilities

    Aug 4, 2026William Bolton, Philip TorrAI Agents for Scientific DiscoveryBenchmark Design

    Department of Engineering Science, University of Oxford, Oxford, United Kingdom.

  17. AgentPanel: Toward a New Paradigm for Human--AI Collaboration in Exploring Scientific Questions

    Aug 4, 2026Zhiyao Cui, Qianyi Wang, Haoyang Yan +26Multi-Agent LLM SystemsScientific Hypothesis Generation

    Shanghai Artificial Intelligence Laboratory

  18. Abduction Without a Body? Representational Grounding and the Abduction Loop for Scientific Hypothesis Generation

    Aug 3, 2026Michael FarmerAbductive ReasoningScientific Hypothesis Generation

    August 2026 (v1.18)

  19. TCA-SIR: Learning Target-Conditioned Abstractions for Scientific Inspiration Retrieval

    Jul 30, 2026Yuto Suzuki, Farnoush Banaei-KashaniAI for ScienceScientific Hypothesis Generation

    Department of Computer Science and Engineering, University of Colorado Denver Denver, Colorado, USA

  20. Can AI Follow In Einstein's Footsteps?

    Jul 30, 2026Michael Shalyt, Nathan Regev, Marin Soljačić +1AI for ScienceScientific Hypothesis Generation

    Technion - Israel Institute of Technology, Haifa 3200003, Israel. · Massachusetts Institute of Technology, Cambridge MA 02139, USA.

  21. Before the Action: Benchmarking LLMs on Prospective Hypothesis Discovery

    Jul 17, 2026Tianyun Zhong, Wangyi Jiang, Wei Wang +15LLM EvaluationScientific Hypothesis Generation

    University of Chinese Academy of Sciences · Institute of Software, Chinese Academy of Sciences · 3Alibaba Group

  22. IdeaTrail: Full-Process Agent Trajectories for Scientific Ideation

    Jul 11, 2026Hengquan GuoAI Agents for Scientific DiscoveryScientific Hypothesis Generation

    ShanghaiTech University

  23. Toward Auditable AI Scientists: A Hypothesis Evolution Protocol for LLM Agents

    Jul 10, 2026Izumi Takahara, Teruyasu MizoguchiAI Agents for Scientific DiscoveryLLM Auditing

    Institute of Industrial Science, The University of Tokyo, Tokyo, Japan 153-8505

  24. Ideas Have Genomes: Benchmarking Scientific Lineage Reasoning and Lineage-Grounded Idea Generation

    Jul 9, 2026Yifan Zhou, Qihao Yang, Yan Li +14Scientific ReasoningScientific Hypothesis Generation

    Shanghai Jiao Tong University · Carnegie Mellon University · University of Chinese Academy of Sciences +4

  25. FirstResearch: Auditable Question Formation for LLM Scientific Discovery Agents

    Jul 6, 2026Yufeng WangScientific Hypothesis GenerationLarge Language Model-Guided Scientific Discovery

  26. EO-Agents: A Three-Agent LLM Pipeline for Earth Observation Hypothesis Generation

    Jul 2, 2026Mahyar Ghazanfari, Amin Tabrizian, Armin Mehrabian +1Multi-Agent LLM SystemsLLM Grounding

    George Washington University, Washington, DC, USA · NASA Goddard Space Flight Center, Greenbelt, MD, USA · ADNET Systems, Inc., Bethesda, MD, USA

  27. Measuring the Gap Between Human and LLM Research Ideas

    Jul 1, 2026Ziyu Chen, Yilun Zhao, Arman CohanLLM EvaluationScientific Hypothesis Generation

    University of Chicago · Yale University

  28. Autonomous Scientific Discovery via Iterative Meta-Reflection

    Jul 1, 2026Bingchen Zhao, Sara Beery, Oisin Mac AodhaScientific Hypothesis GenerationAutonomous Scientific Discovery

    University of Edinburgh · Massachusetts Institute of Technology

  29. Graph-Native Reinforcement Learning Enables Traceable Scientific Hypothesis Generation through Conceptual Recombination

    Jul 1, 2026Subhadeep Pal, Shashwat Sourav, Tirthankar Ghosal +1LLM Reasoning with GraphsRL for Language Model Reasoning

    Department of Civil and Environmental Engineering MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA, USA · Department of Physics Washington University in St. Louis St. Louis, MO, USA · Computing and Computational Sciences Directorate Oak Ridge National Laboratory Oak Ridge, TN, USA +3

  30. Agentic-Ideation: Sample Efficient Agentic Trajectories Synthesis for Scientific Ideation Agents

    Jun 30, 2026Keyu Zhao, Lingyan Kong, Fengli Xu +1Multi-Agent LLM SystemsAI Agents for Scientific Discovery

    Department of Electronic Engineering, Tsinghua University.

  31. Evidence-Informed LLM Beliefs for Continual Scientific Discovery

    Jun 28, 2026Dhruv Agarwal, Reece Adamson, Andrew McCallum +3Scientific Hypothesis GenerationBelief Updating in LLMs

    University of Massachusetts Amherst · Allen Institute for AI

  32. Socratic agents for autonomous scientific discovery in high-dimensional physical systems

    Jun 25, 2026Xianrui Zeng, Pengfei Liu, Yirui Zang +5Scientific Hypothesis GenerationAutonomous Scientific Discovery

    Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, 310024, China. · Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai, 201800, China. · Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, China. +1

  33. AI Scientists as Engines of Discovery: A Case for Development within Reformed Institutions

    Jun 22, 2026Raul Jimenez, Boris Bolliet, Francisco Villaescusa-Navarro +7AI Agents for Scientific DiscoveryScientific Hypothesis Generation

    Institute of Cosmos Sciences (ICCUB), University of Barcelona, Barcelona, Spain · ICREA, Barcelona, 08010, Spain · Cavendish Astrophysics, University of Cambridge, Madingley Road, Cambridge CB3 0HA, UK +10

  34. Discovery under Hypothesis Redundancy: A Geometric Theory of Discovery Bottlenecks

    Jun 12, 2026Li Xia, Baoxun WangScientific Hypothesis GenerationLarge Language Model-Guided Scientific Discovery

    School of Economics and Management, Tsinghua University · Platform & Content Group, Tencent

  35. Towards Diverse Scientific Hypothesis Search with Large Language Models

    Jun 9, 2026Haorui Wang, Parshin Shojaee, Kazem Meidani +7Automated Algorithm DiscoveryScientific Hypothesis Generation

    Georgia Institute of Technology · Virginia Tech · Carnegie Mellon University +3

  36. Graph2Idea:Retrieval-Augmented Scientific Idea Generation with Graph-Structured Contexts

    Jun 8, 2026Xu Li, Hanzhe Tu, Xun HanGraph Retrieval-Augmented GenerationScientific Hypothesis Generation

    Southwest Petroleum University, Chengdu, Sichuan, China · Sichuan Police College, Luzhou, Sichuan, China

  37. DN-Hypo-Pipeline: An AI-Driven Workflow for Generating Hypotheses using Large Language Models and Scientific Explanations

    Jun 7, 2026Lei Lin, Ronghao Wang, Chunbao Zhou +2Scientific ReasoningScientific Hypothesis Generation

    Computer Network Information Center, Chinese Academy of Sciences, China

  38. Contemporary AI lacks the imagination to diverge or negate in science

    Jun 6, 2026Honglin Bao, Siyang Wu, Xiao Liu +3LLM-as-a-JudgeScientific Reasoning

    Data Science Institute, University of Chicago · Knowledge Lab, University of Chicago

  39. Conditional Hypothesis Generation for LLM-Based Text Analysis with Researcher-Specified Covariates

    Jun 2, 2026Paiheng Xu, Jing Liu, Wei AiScientific Hypothesis GenerationComputational Social Science

    University of Maryland, College Park

  40. EvoGens: A Population-Based Heuristic Search Framework for Scientific Idea Generation

    May 29, 2026Xu Li, Hanzhe Tu, Xinyi Li +3Scientific Hypothesis GenerationResearch Idea Generation

    Southwest Petroleum University, Chengdu, China · Sichuan Police College, Luzhou, China

  41. ProjectionBench: Evaluating Scientific Hypothesis Generation in LLMs Under Progressive Information Disclosure

    May 28, 2026A. J. Lew, Y. Cao, M. J. BuehlerLLM EvaluationScientific Reasoning

    Unreasonable Labs · Unreasonable Labs Mountain View, CA 94043, USA

  42. MOOSE-Copilot: A Web-Based Interactive Assistant for Unified Exploratory and Fine-Grained Scientific Hypothesis Discovery

    May 28, 2026Hongran An, Zonglin YangScientific Hypothesis GenerationHuman-in-the-Loop AI

    Central Conservatory of Music · Nanyang Technological University

  43. AI Research Agents Narrow Scientific Exploration

    May 27, 2026Yixuan Tang, Yi YangAI Agents for Scientific DiscoveryAI Agent Evaluation

    1*ISOM, The Hong Kong University of Science and Technology.

  44. The Compressive Knowledge Graph Hypothesis: Which Graph Facts Matter for Scientific Hypothesis Generation?

    May 26, 2026Shashwat Sourav, Viktoriia Baibakova, Sanjay Das +4LLM GroundingLLM Reasoning with Graphs

    1Washington University in St. Louis · 2Oak Ridge National Laboratory · 3Lawrence Berkeley National Laboratory +1

  45. Can Broad Biomedical Knowledge be Contextualized into Scenario-Grounded Propositions?

    May 26, 2026Qingyuan Zeng, Ziyang Chen, Pengxiang Cai +5Evidence-Grounded ReasoningScientific Hypothesis Generation

    The Hong Kong University of Science and Technology (Guangzhou) · Guangzhou University of Chinese Medicine

  46. Hypothesis Generation and Inductive Inference in Children and Language Models

    May 23, 2026Jeffrey Qin, Wasu Top Piriyakulkij, Zhuangfei Gao +4Bayesian InferenceScientific Hypothesis Generation

    Computer Science University of Waterloo · Department of Computer Science Cornell University · Department of Computer Science Dalhousie University +1

  47. LLM-AutoSciLab: Closed-Loop Scientific Discovery via Active Experimentation with LLMs

    May 21, 2026Sanchit Kabra, Nikhil Abhyankar, Saaketh Desai +2Scientific DiscoveryScientific Hypothesis Generation

    1Virginia Tech · 2Sandia National Laboratories

  48. EvoSci: A Bio-Inspired Multi-Agent Framework for the Evolution of Scientific Discovery

    May 20, 2026Xiaoyu Xiong, Yuqi Ren, Deyi XiongScientific Hypothesis GenerationMulti-Agent Collaboration

    TJUNLP Lab, School of Computer Science and Technology, Tianjin University, China

  49. Evidence-Grounded Frontier Mapping and Agentic Hypothesis Generation in Nanomedicine

    May 18, 2026Christiaan G. A. Viviers, Koen de Bruin, Mirre M. Trines +6Scientific Hypothesis GenerationEvidence-Grounded Generation

    ARIA Lab, Signal Processing Systems, Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. · Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. · The Louis Family Laboratory for Targeted Drug Delivery and Personalized Medicine Technologies, Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa, Israel. +2

  50. Graphs of Research: Citation Evolution Graphs as Supervision for Research Idea Generation

    May 14, 2026Songyang Gao, Yinghui Xia, Siyi Liu +1Scientific Hypothesis GenerationResearch Idea Generation

    The Hong Kong University of Science and Technology (Guangzhou) · Tsinghua University · The Hong Kong University of Science and Technology

  51. LLM Jaggedness Unlocks Scientific Creativity

    May 11, 2026Shray Mathur, J. Anibal Boscoboinik, Esther H. R. Tsai +1Creativity AssessmentLLM Evaluation

    Center for Functional Nanomaterials, Brookhaven National Laboratory Upton, NY 11973, USA

  52. Agentic AI Scientists Are Not Built For Autonomous Scientific Discovery

    May 9, 2026Harshit Bisht, Vinay Kumar, Kevin Maik Jablonka +2AI Agents for Scientific DiscoveryScientific Hypothesis Generation

    Yardi School of Artificial Intelligence, Indian Institute of Technology Delhi · Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena · Center for Energy and Environmental Chemistry Jena, Friedrich Schiller University Jena +3

  53. LLM-Guided Open Hypothesis Learning from Autonomous Scanning Probe Microscopy Experiments

    May 7, 2026Boris Slautin, Utkarsh Pratiush, Yu Liu +2Scientific Hypothesis GenerationLarge Language Model-Guided Scientific Discovery

    Department of Materials Science and Engineering, University of Tennessee, Knoxville, TN 37923, USA

  54. More Than Can Be Said: A Benchmark and Framework for Pre-Question Scientific Ideation

    May 7, 2026Jie Yu, Song QiuAI for ScienceScientific Hypothesis Generation

    Shanghai Key Laboratory of Multidimensional Information Processing East China Normal University Shanghai, 200241

  55. Hypothesis generation and updating in large language models

    May 7, 2026Hua-Dong XiongLogical ReasoningBayesian Inference

    School of Psychological and Brain Sciences Georgia Tech

  56. Evolving Idea Graphs with Learnable Edits-and-Commits for Multi-Agent Scientific Ideation

    May 6, 2026Jiangwen Dong, Bo Li, Wanyu LinMulti-Agent LLM SystemsScientific Hypothesis Generation

    1The Hong Kong Polytechnic University · 2The Hong Kong University of Science and Technology

  57. An explainable hypothesis-driven approach to Drug-Induced Liver Injury with HADES

    May 4, 2026Maciej Wisniewski, Bartosz Topolski, Pawel Dabrowski-Tumanski +2Explainable Artificial IntelligenceAI Agents for Scientific Discovery

    Ingenix.ai, Warsaw, Poland · Laboratory of Bioinformatics and Computational Genomics, Warsaw University of Technology, Warsaw, Poland · Laboratory of Functional and Structural Genomics, Centre of New Technologies, University of Warsaw, Warsaw, Poland

  58. Structure Liberates: How Constrained Sensemaking Produces More Novel Research Output

    May 1, 2026James Mooney, Zae Myung Kim, Young-Jun Lee +1AI Agents for Scientific DiscoveryScientific Hypothesis Generation

    University of Minnesota

  59. A phenotype-driven and evidence-governed framework for knowledge graph enrichment and hypotheses discovery in population data

    Apr 18, 2026Adela Bâra, Simona-Vasilica OpreaScientific Hypothesis GenerationKnowledge Graphs

    Department of Economic Informatics and Cybernetics, Bucharest University of Economic Studies, Bucharest, Romania

  60. Debate as Reward: A Multi-Agent Reward System for Scientific Ideation via RL Post-Training

    Apr 17, 2026Moein Salimi, Babak Hosseini Mohtasham, Amin Aghakasiri +6Reward HackingRL for Language Models

    Sharif University of Technology · University of Tehran · Sharif University of Technology[cs.AI]