Conditional Diffusion Models

Low-density EEG is more suitable for wearable and IoT-based brain sensing, but sparse electrode sampling often lacks sufficient spatial information to characterize cross-regional neural activity. EEG spatial super-resolution aims to recover dense-channel EEG from sparse recordings, yet remains challenging because channel missingness typically occurs at the whole-channel level, spatiotemporal dependencies over the full electrode layout are often underexplored, and the mapping from sparse to dense signals is inherently ambiguous. To address these issues, we propose TGSD, a topology-guided state-space diffusion framework for EEG spatial super-resolution. TGSD first employs a Hierarchical Spatial Prior Encoder to learn topology-aware priors over the complete electrode layout by integrating local geometric relationships with region-level contextual information. Based on these priors and sparse observations, a Conditional State-Space Diffusion Reconstructor progressively generates missing-channel signals through reverse diffusion, while alternating temporal and channel-wise state-space modeling captures long-range temporal dynamics and inter-channel dependencies in a unified framework. Experiments on the SEED and PhysioNet MM/I datasets show that TGSD consistently outperforms representative baselines under different super-resolution factors in both reconstruction fidelity and downstream classification performance. These results demonstrate the effectiveness of combining topology-aware spatial priors with conditional diffusion for enhancing practical low-density EEG sensing in wearable and IoT scenarios. The official implementation code is available at https://github.com/jtggz/TGSD.

Survival analysis aims to estimate a time-to-event distribution from data with censored observations. Many existing methods either impose structural assumptions on the hazard function or discretize the time axis, which may limit flexibility and introduce approximation errors. We propose the Survival Diffusion Probabilistic Model (SDPM), a generative approach to continuous-time survival analysis. SDPM models the conditional distribution of the survival outcome, represented by the pair of observed time and censoring indicator, $\mathbb{P}(T,δ\mid \mathbf{x})$, using a denoising diffusion model. Under the assumption of conditionally independent censoring, conditional samples generated by the model can be transformed into survival function estimates using the Kaplan-Meier estimator. This formulation avoids parametric assumptions on the event-time distribution and does not require a discretization of the output time space. The model operates in a transformed target space, using standardized log-times and a continuous Gaussian-mixture representation of the censoring indicator. We evaluate SDPM on ten real survival datasets and compare it with five strong baselines, including tree-based, boosting-based, and neural survival models. Results show that SDPM achieves competitive predictive performance across C-index, integrated time-dependent AUC, and integrated Brier score. A study on synthetic Cox-Weibull data demonstrates that SDPM can recover the shape of an underlying continuous survival distribution more accurately than a strong nonparametric baseline when sufficiently many samples are generated. An ablation study confirms the importance of the proposed target-space transformations, which improve event-rate calibration, reduce invalid generated times, and provide consistent gains in predictive discrimination. Codes implementing the proposed model are publicly available.

Identity-conditioned diffusion models enable high-quality and identity-consistent face generation, but they also raise severe privacy concerns, as models may continue to synthesize individuals despite their right to be forgotten. While machine unlearning has been extensively studied for concept and data removal, identity unlearning remains largely unexplored, particularly in models conditioned directly on identity embeddings rather than text prompts. In this work, we study identity unlearning in Arc2Face, a state-of-the-art identity-conditioned latent diffusion model for face generation, and introduce Proximity-guided Identity Unlearning (PIU), an anchor-guided framework for identity unlearning. Specifically, we formulate identity removal as an identity replacement objective that reassigns the source identity to a selected anchor identity in the learned identity space, and we complement it with a proximity-based anchor selection strategy motivated by the geometry of ArcFace representations. We further show that effective unlearning can be achieved through localized fine-tuning of a small subset of identity-sensitive cross-attention layers. Experiments across multiple target identities show that our framework effectively suppresses generation of the target identity while preserving realism and identity consistency for retained identities, as validated by improved performance on unlearning and image-quality metrics, together with qualitative evaluation. The source code for the PIU identity unlearning framework is made publicly available at https://github.com/edgarcancinoe/piu-unlearning.

Deepgenerative models havebecomeapromisingapproach for human motion prediction due to their ability to capture multimodal distributions and represent diverse human be haviors. However, generating predictions that are both di verse and jointly consistent among interacting agents re mains challenging. In addition, most existing approaches are primarily evaluated using single-agent (marginal) met rics, which fail to fully reflect the joint dynamics of multi agent interactions. We propose a diffusion-based frame work that improves multi-agent motion prediction by lever aging rich contextual information from historical trajecto ries. This information is incorporated through a guidance mechanism to enhance the diversity and expressiveness of predicted motions. To further enforce interaction consis tency, we introduce an energy-based formulation that re fines the joint trajectory distribution while preserving the plausibility of individual trajectories. Extensive experi ments on four benchmark datasets demonstrate that our approach consistently outperforms existing methods. No tably, our approach substantially improves both marginal (ADE/FDE) and joint (JADE/JFDE) metrics on ETH/UCY over strong marginal baselines. Compared with prior joint prediction methods, it delivers significant gains in marginal metrics while maintaining competitive joint performance.

Cone-beam CT (CBCT) is routinely acquired during radiotherapy for patient setup, but its quantitative reliability is degraded by scatter, noise, and reconstruction artifacts, limiting Hounsfield Unit (HU) accuracy. We propose EPC-3D-Diff, a novel conditional 3D latent diffusion framework for volumetric CBCT to CT synthesis that introduces a projection domain equivariance loss derived from acquisition physics. Unlike common image domain equivariance, we exploit the fact that an in plane rotation of the volume corresponds to an angular shift in its projections. During training, we enforce this relationship by forward projecting rotated synthesized CT volumes and matching them to appropriately angle shifted projections of the paired target CT, yielding a physics consistent equivariance constraint integrated into the diffusion objective. To capture full 3D context efficiently, conditional diffusion is performed in a compact latent space learnt by a lightweight 3D autoencoder, preserving axial depth while downsampling in plane resolution for stable training. We validate on a paired head CBCT/CT phantom dataset, including repeat scans, and paired clinical data using patient wise splits, and perform single and mixed domain training, ablations, and comparisons with diffusion and CycleGAN. EPC-3D-Diff generalizes well and achieved substantial improvements, +7.4 dB (phantom) and +1.8 dB (clinical data) in PSNR compared to state of the art methods, alongside improved SSIM and HU accuracy, within tissue boundaries. Overall, EPC-3D-Diff improves robustness and physics consistency, supporting HU aware synthesis for downstream radiotherapy workflows. The open source code for EPC-3D-Diff is available at https://github.com/ALZAHRAALTALIB/EPC-3D-Diff.

Airfoil shape design is a fundamental task in aerospace engineering, with a direct impact on flight stability and fuel consumption. Deep learning has recently emerged as a promising tool for this task, but existing deep generative approaches remain limited in both geometric validity and physical controllability. They offer little control over the generated shapes, yielding invalid geometries, and they typically do not condition effectively on aerodynamic performance. To address these issues, this paper proposes AirfoilGen, a valid-by-construction and performance-aware latent diffusion model for airfoil. It first introduces a novel airfoil representation scheme, the circle sweeping representation, to constrain the generative process so that output shapes respect essential airfoil characteristics. It then enables explicit control over aerodynamic performance (e.g., lift and drag coefficients) by operating in a learned latent space: a transformer model encodes airfoil shapes into vector embeddings, and a conditional diffusion model denoises Gaussian noise into these latent embeddings while incorporating target aerodynamic performance. In addition, this paper presents a new dataset of over 200,000 airfoils, which is substantially larger than the widely used UIUC airfoil dataset (1,650 airfoils) and more suitable for training modern deep generative models. Experiments demonstrate that AirfoilGen enables airfoil generation with far greater geometric validity and aerodynamic performance controllability than previously achievable, with an average performance-conditioning accuracy of 98.41%.

Inverse design of metasurfaces under continuous electromagnetic constraints requires generation of geometries that simultaneously satisfy stringent spectral specifications and remain manufacturable. Conventional approaches based on iterative full wave simulations are computationally prohibitive for large design spaces, while existing generative models often suffer from poor conditional controllability and limited fabrication awareness. In this regard, we propose a physics guided condition quality enhanced diffusion framework for the inverse design of metasurface based absorbers. Fabrication-aware constraints are incorporated to ensure practical realizability of the generated designs. The framework introduces a conditioning mechanism for continuous spectral specifications, wherein feature-wise linear modulation propagates the condition across the denoising hierarchy, enabling stable and accurate generation with improved spectral controllability. Further, to embed EM consistency directly into the generative learning process, a pre trained surrogate EM simulator is integrated within the diffusion training pipeline. The proposed framework generated physically realizable metasurface designs for diverse reflection characteristics in the frequency range of 2 to 18 GHz, achieving a very low average spectral mean squared error of 0.0006 and a high band alignment accuracy of 0.958. The framework also addresses the fundamentally non-unique nature of inverse EM design by enabling structured multimodal generation of geometrically distinct yet spectrally consistent metasurface designs for the same target response. The proposed model produces the suitable design in approximately 30 seconds, whereas the conventional approach can take several months under comparable computational resources. The efficiency of the model is also established via experimental measurements.

Photoplethysmography (PPG) has become a ubiquitous physiological signal; however, current generative models still struggle to preserve realistic waveform morphology and learn a latent structure that captures cardiac and respiratory physiology. PPG generators trained with adversarial losses can produce plausible waveforms, but provide no inference path from a real signal to a latent representation. Variational autoencoders, on the other hand, map the PPG data to latent codes, although their decoders often blur systolic upstrokes and dampen amplitude and spectral details. Diffusion models improve waveform fidelity, but typically lack an inference path for reconstruction and physiological analysis. We propose VampPrior Latent Diffusion (VAMP-Diff), a jointly trained variational diffusion model that combines a temporal PPG encoder, a conditional one-dimensional diffusion decoder, and VampPrior regularization on a compact pooled latent. The model uses full temporal latent during diffusion reconstruction, giving the decoder access to beat timing and morphology while generating samples from learned VampPrior components instead of a fixed Gaussian prior. We demonstrate on the CapnoBase dataset that VAMP-Diff produces realistic PPG signals, reconstructs sharper physiological waveforms than Gaussian-prior baselines, preserves heart-rate information, maintains respiratory-rate consistency, and is sensitive to waveform corruptions through reconstruction error.

Electrocardiogram (ECG)-based models have achieved strong performance in diagnostic tasks, yet they remain limited in modeling how cardiac dynamics evolve under external interventions. In particular, existing approaches focus primarily on static prediction and lack mechanisms to capture ECG variations under different pharmacological conditions. In this work, we propose an ECG World Model for action-conditioned predictive simulation of cardiac electrophysiology. Moving beyond disjoint pipelines, our framework features a principled integration of physiological ordinary differential equation (ODE) priors into latent diffusion dynamics via energy regularization. This structural constraint enables the synthesis of physiologically plausible post-intervention ECG trajectories while effectively mitigating generative hallucinations. Building on this simulation process, we introduce an uncertainty-aware evaluation strategy that leverages the stochasticity of diffusion sampling to characterize both the expected clinical risk and its variability, allowing a more reliable comparative assessment of candidate interventions. We evaluate our method across diverse settings, including controlled drug-response scenarios and real-world clinical records. Beyond standard waveform metrics, experimental results demonstrate improved risk calibration and strong alignment with expert-informed treatment preferences. These results establish our approach as a robust foundation for safe and intervention-aware clinical decision support.

Stipple patterns, point sets whose local density tracks a target image, are traditionally produced by per-density iterative optimizers, which are slow, non-differentiable, and must be re-run from scratch for each new target. Learned alternatives have so far addressed only unconditional point generation; capacity-constrained, image-conditioned stippling has remained out of reach. We present the first diffusion-based sampler that simultaneously satisfies a learned local point-distribution prior and a continuous, image-defined capacity constraint at inference. The method is a ControlNet branch built on top of an optimal-transport-grid point-set diffusion baseline, conditioned on the target density map and a high-resolution image. Two design choices make the combination tractable: training and inference are restricted to the late-stage denoising regime, initialized from a density-weighted rejection sample, and the standard zero-convolution injection is replaced with a sigmoid-gated 1x1 projection that preserves the base model's blue-noise structure under hard density signals. A single trained checkpoint accepts arbitrary target densities at inference, generalizes to point budgets that were not seen during training, and produces stipples in time nearly independent of the output point count. On the Icons-50 benchmark, our learned sampler reaches parity with per-density-optimized baselines on every reported metric while remaining differentiable end-to-end.

Recently, diffusion-based material transfer methods rely on image fine-tuning or complex architectures with auxiliary networks but face challenges such as text dependency, additional computational costs, and feature misalignment. To address these limitations, we propose \textbf{DealMaTe}, using \underline{\textbf{de}}pth, norm\underline{\textbf{a}}l, and \underline{\textbf{l}}ighting images for \underline{\textbf{ma}}terial \underline{\textbf{t}}ransf\underline{\textbf{e}}r. DealMaTe is a simplified diffusion framework that eliminates text guidance and reference networks. We design a lightweight 3D information injection method, Multi-Dim 3D Shader LoRA, which, without modifying the base model weights, enables compatible control conditions and achieves harmonious and stable results. Additionally, we optimize the attention mechanism with Shader Causal Mutual Attention and key-value (KV) caching to reduce inference latency caused by multiple conditions, improve computational efficiency, and achieve high-quality material transfer results with low architectural complexity. Extensive experiments covering a wide variety of objects and lighting conditions consistently demonstrate that DealMaTe achieves remarkable high-fidelity material transfer under arbitrary input materials. The code is available at https://github.com/haha-lisa/DealMaTe.

Recent diffusion-based methods for material transfer rely on image fine-tuning or complex architectures with assistive networks, but face challenges including text dependency, extra computational costs, and feature misalignment. To address these limitations, we propose MaTe, a streamlined diffusion framework that eliminates textual guidance and reference networks. MaTe integrates input images at the token level, enabling unified processing via multi-modal attention in a shared latent space. This design removes the need for additional adapters, ControlNet, inversion sampling, or model fine-tuning. Extensive experiments demonstrate that MaTe achieves high-quality material generation under a zero-shot, training-free paradigm. It outperforms state-of-the-art methods in both visual quality and efficiency while preserving precise detail alignment, significantly simplifying inference prerequisites.

Face restoration under complex degradations still remains an ill-posed inverse problem due to severe information loss. Although diffusion models benefit from strong generative priors, most methods still condition only on low-quality inputs, making it difficult to recover identity-critical details under heavy degradations. In this work, we propose HDRFace, a High-Dimensional Representation conditioned Face restoration framework that injects semantically rich priors into the conditional flow without modifying the generative backbone. Our pipeline first obtains a structurally reliable intermediate restoration with an off-the-shelf restorer, then uses a pretrained high-dimensional feature encoder to extract fine-grained facial representations from both the low-quality input and the intermediate result, and injects them as additional conditions for generation. We further introduce SDFM, a Structure-Detail aware adaptive Fusion Mechanism that emphasizes global constraints during structure modeling and strengthens representation guidance during detail synthesis, balancing structural consistency and detail fidelity. To validate the generalization ability of our method, we implement the proposed framework on two generative models, SD V2.1-base and Qwen-Image, and consistently observe stable and coherent performance gains across different architectures.

When reliable target structures are unavailable at scale or phenotypes arise from dysregulated pathways, transcriptomic perturbations provide a system-level functional readout for drug action. In this work, we formalize \emph{Transcriptome-based Drug Design (TBDD)} as a generative inverse problem: designing drug molecules conditioned on desired transcriptomic state transitions. We analyze the inherently ill-posed nature of this task, which is further complicated by the profound domain gap between biology and chemistry and by the sparsity of transcriptomic signals. To address these challenges, we propose \textbf{\themodel{}} (A \textbf{C}ell\textbf{U}lar \textbf{R}esponse \textbf{E}ngine), a multi-resolution transcriptome-guided diffusion framework. \themodel{} features a specialized \textbf{Transcriptome Perturbation Functional Feature Extractor (TFE)} that (1) distills function-oriented perturbation embeddings from pre/post states, (2) aligns these signatures to dual chemical views to bridge the cross-modal gap, and (3) performs heterogeneity-aware aggregation to extract robust state-specific signals from noisy transcriptomic data. Extensive evaluations on both standard benchmarks and rigorous out-of-distribution protocols demonstrate that \themodel{} consistently outperforms strong baselines in structural quality and functional consistency. Furthermore, we validate its practical utility via a zero-shot gene-inhibitor design task, highlighting the potential of phenotype-driven generative discovery.

Continuous diffusion language models require choosing a representation space in which denoising operates, yet it remains unclear which representations are most compatible with diffusion. We study a basic design question: where inside a pretrained language model should continuous diffusion operate? We formulate this as a hidden-state interface-selection problem and hypothesize that diffusion-friendly interfaces can be identified from representation geometry. We operationalize this hypothesis using three training-free geometric proxies: local compactness, global stiffness, and effective rank. Across two 8B-scale backbones, the resulting geometry score predicts fixed-budget diffusion bridgeability beyond the dominant effect of layer depth. We then instantiate DiHAL, a Locate-and-Replace framework that replaces the transformer prefix below a selected interface with conditional diffusion while retaining the pretrained suffix and LM head. Under full training, geometry-selected interfaces remain close to validation-loss oracles and outperform worst-layer controls, while the diffusion bridge outperforms a parameter-matched deterministic replacement under matched diagnostic conditions. These results suggest that the representation space in which diffusion operates should itself be treated as a first-class design variable for continuous diffusion in language models.

Trajectory-controlled human motion generation aims to synthesize realistic human motions conditioned on both textual descriptions and spatial trajectories. However, existing methods suffer from two critical limitations: first, the conflict between text and trajectory conditions disrupts the denoising process, resulting in compromised motion quality or inaccurate trajectory following; second, the use of redundant motion representations introduces inconsistencies between motion components, leading to instability during trajectory control. To address these challenges, we propose CMC, a decoupled framework that effectively coordinates text and trajectory conditions through a divide-and-conquer strategy. CMC follows a divide-and-conquer paradigm, comprising two cascaded stages: Trajectory Control and Motion Completion. In the first stage, a diffusion model generates a simplified representation of the controlled joints under trajectory guidance, based on the given trajectories, ensuring accurate and stable trajectory following. In the second stage, a text-conditioned diffusion inpainting model generates full-body motions using the simplified representation from the first stage as partial observations. To mitigate overfitting caused by limited inpainting training data, we further introduce the Selective Inpainting Mechanism (SIM), which alternates between text-to-motion generation and motion inpainting tasks during training. Experiments on HumanML3D and KIT datasets demonstrate that CMC achieves state-of-the-art performance in control accuracy and motion quality, demonstrating its effectiveness in coordinating multimodal conditions and representations.

Symbolic-control drum generation requires preserving explicit event timing and dynamics while synthesizing acoustically plausible waveforms. We present Sec2Drum-DAC, a conditional latent-diffusion model for symbolic-to-audio drum rendering. The model conditions on event features sampled in physical time at codec-frame locations and predicts standardized principal-component coordinates of frozen DAC summed-codebook embeddings rather than waveform samples. In the evaluated DAC configuration, 72 principal components capture the observed training-frame summed-latent subspace under the stated SVD threshold, yielding a compact continuous denoising target with a deterministic reconstruction path to the 1024-dimensional DAC latent space before waveform decoding. Across 1,733 held-out four-beat windows, PCA diffusion improves paired spectral and transient metrics over deterministic PCA regression and a symbolic rendering baseline, while direct regression remains stronger on phase-sensitive waveform L1. Auxiliary RVQ cross-entropy improves short-step diffusion on mel error, onset-flux cosine, and waveform L1, with the most favorable trade-offs occurring at 6-25 denoising steps depending on the metric.

Recent advances in generative models have yielded impressive progress on motion in-betweening, allowing for more complex, varied, and realistic motion transitions. However, recent methods still exhibit noticeable limitations in preserving keyframe information and ensuring motion continuity. In this paper, we propose a novel pipeline and sampling optimization strategy for latent diffusion models (LDM) based on motion implicit neural representations (INR). By establishing a mapping between INR and sparse spatial or temporal information within latent diffusion, our model can sample the INR parameters from extremely sparse and ambiguous keyframe data and reconstruct plausible and smooth motions from the manifold. Our experiments demonstrate the superior performance of our model, which significantly improves motion generation quality in scenarios with few keyframes while ensuring both keyframe accuracy and diversity of in-between motions.

Recognition of handwritten Bangla compound characters remains a challenging problem due to complex character structures, large intra-class variation, and limited availability of high-quality annotated data. Existing Bangla handwritten character recognition systems often struggle to generalize across diverse writing styles, particularly for compound characters containing intricate ligatures and diacritical variations. In this work, we propose a confidence-guided diffusion augmentation framework for low-resolution Bangla compound character recognition. Our framework combines class-conditional diffusion modeling with classifier guidance to synthesize high-quality handwritten compound character samples. To further improve generation quality, we introduce Squeeze-and-Excitation enhanced residual blocks within the diffusion model's U-Net backbone. We additionally propose a confidence-based filtering mechanism where pre-trained classifiers act as quality gates to retain only highly class-consistent synthetic samples. The filtered synthetic images are fused with the original training data and used to retrain multiple classification architectures. Experiments conducted on the AIBangla compound character dataset demonstrate consistent performance improvements across ResNet50, DenseNet121, VGG16, and Vision Transformer architectures. Our best-performing model achieves 89.2% classification accuracy, surpassing the previously published AIBangla benchmark by a substantial margin. The results demonstrate that quality-aware diffusion augmentation can effectively enhance handwritten character recognition performance in low-resource script domains.

Protein function is often controlled by ligands that bias the direction of state transitions, such as agonists and antagonists, rather than stabilizing a single conformation. This is especially important for clinically relevant G protein-coupled receptors (GPCRs), where therapeutic efficacy depends on functional directionality. Structure-based design methods optimize binding to static conformations and cannot represent non-reversible, directional effects or systematically distinguish agonist from antagonist behavior. To address this gap, we introduce Transition-Directed Discrete Diffusion for Allosteric Binder Design (TD3B), a sequence-based generative framework that designs binders with specified agonist or antagonist behavior via a directional transition control objective. TD3B combines a target-aware Direction Oracle, a soft binding-affinity gate, and amortized fine-tuning of a pre-trained discrete diffusion model, enabling targeted agonist and antagonist generation decoupled from binding affinity and unattainable by equilibrium-based or inference-only guidance baselines. The code and checkpoints are available at https://huggingface.co/ChatterjeeLab/TD3B.

Despite the central role of sensor-derived measurements such as imaging traits and plasma biomarkers in biomedical research and clinical practice, existing generative models for disease prediction largely depend on event-level representations from hospital and registry data. Given the multi-factorial nature of human disease, the absence of explicit modeling of social determinants of health (SDoH), even in the limited form of ICD-coded proxies (chapters Z and V--Y in ICD-10), limits the capacity for personalized disease modeling and clinical decision support. To address this limitation, we propose a generative model with ICD-coded proxies of SDoH for \textit{in silico} modeling of disease reasoning, a conditioned latent diffusion framework that establishes the connection between multi-organ sensor data with tokenized healthcare events. Specifically, we introduce a novel geometric diffusion model to characterize the temporal evolution of complex data representation such as brain networks (region-to-region connectivity encoded in a graph), in parallel with diffusion models for tabular data from other organ systems. Together, we integrate the generative model with digitalized SDoH proxies (coined \modelname{}) for simulated intervention and reasoning of future disease trajectories. We conduct extensive experiments on the UK Biobank (UKB) dataset, which contains organ-specific imaging traits, including brain (44,834), heart (23,987), liver (28,722), and kidney (32,155), along with nearly 500k medical history sequences (age range: 25$\sim$89 years). Our \modelname{} achieves significant improvements over state-of-the-art human disease autoregressive models and imaging trait generative baselines.

Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models trained on billion-scale datasets from vision domains have achieved impressive performance. Herein, we propose DiffKT3D, a unified Any2Any 3D diffusion framework that leverages prior knowledge from pretrained video diffusion models for efficient and clinically meaningful dose prediction. To enable flexible conditioning across multiple clinical modalities (CT, anatomical structures, body, beam settings, etc.), we introduce an Any2Any conditional paradigm utilizing modality-specific embeddings without cross-attention overhead. Further, we design a novel reinforcement learning (RL) post-training mechanism guided by a clinically-informed Scorecard explicitly tailored to institutional treatment preferences. Compared with winner of GDP-HMM challenge, DiffKT3D sets a new state-of-the-art in dose prediction by reducing voxel-level MAE from 2.07 to 1.93. In addition, DiffKT3D achieves superior image quality and preference match. These results demonstrate that transferring diffusion priors via modality-aware conditioning and clinically aligned RL post-training can provide a robust and generalizable solution for RT planning across various clinical scenarios.

Talking-head generation requires joint modeling of identity, head pose, facial expression, and mouth dynamics. Existing methods typically address only a subset of these factors, and rely on fixed-weight or heuristic fusion when multiple conditions are involved. We present MoCoTalk, a multi-conditional video diffusion framework that unifies four complementary control signals: a reference image, facial keypoints, 3DMM-rendered shading meshes, and the corresponding speech audio. To resolve destructive interference among heterogeneous conditions, we introduce an Adaptive Multi-Condition Router that computes channel-wise, timestep-aware gating over the four condition streams, allowing the fusion strategy to vary with both feature subspace and noise level. To better capture speech-related facial dynamics, we design a Mouth-Augmented Shading Mesh, a 3DMM-based representation that decouples head motion, mouth motion, expression, and lighting. This design provides a temporally consistent geometric prior and allows flexible recombination of these attributes at inference. We further introduce a lip consistency loss to tighten audio-visual alignment. Extensive experiments show that MoCoTalk achieves state-of-the-art performance on the majority of structural, motion, and perceptual metrics, while offering attribute-level controllability that single-condition methods do not provide.

RGB-to-hyperspectral image reconstruction is a highly ill-posed inverse problem, since multiple plausible spectral distributions may correspond to the same RGB observation. Existing regression-based methods usually learn a deterministic mapping, which limits their ability to model reconstruction uncertainty and often leads to over-smoothed spectral responses. Although diffusion models provide strong distribution modeling capability, their direct application to hyperspectral reconstruction remains challenging due to the high spectral dimensionality, strong inter-band correlations, and strict requirement for spectral fidelity. To this end, we propose R2H-Diff, an efficient diffusion-based framework tailored for RGB-to-HSI reconstruction. Specifically, R2H-Diff formulates spectral recovery as a conditional iterative refinement process, enabling progressive reconstruction under RGB guidance. We proposed a Guided Spectral Refinement Module for RGB-conditioned feature fusion and a Hyperspectral-Adaptive Transposed Attention module for efficient spatial--spectral dependency modeling. Furthermore, a normalization-free denoising backbone is adopted to preserve spectral amplitude consistency, while a task-adapted linear noise schedule enables high-quality reconstruction with only five denoising steps. Extensive experiments on NTIRE2022, CAVE, and Harvard demonstrate that R2H-Diff achieves a favorable balance between reconstruction quality and computational efficiency. Notably, on NTIRE2022, R2H-Diff obtains 35.37 dB PSNR with a sub-million-parameter model of 0.58M parameters and 12.25G FLOPs, achieving the lowest model complexity among the evaluated methods while maintaining strong reconstruction fidelity.

Inverse design of RF passive components from S-parameters is a high-dimensional, ill-posed problem, and prior generative approaches are limited to single-layer binary-metallization structures. This paper presents an inverse design approach that generates passive components from partial S-parameter inputs on an $8\times8$ mm board discretized at $64\times64$ pixels with sub-pixel grayscale metallization across 1-20 GHz. The framework generates two-layer copper layouts with vias, with hard physical constraints on feed locations enforced through annealed Langevin projection, flexible multi-modal conditioning on partial S-parameter specifications, port locations, dielectric properties, reference topology, and variable port placement. Candidate designs are generated in seconds, with surrogate-predicted S-parameters matching targets to within $0.77 \pm 1.28$ dB weighted mean absolute error. We validate the approach with two fabricated designs on RO4003C: a manufacturable alternative to a hairpin filter whose coupling gaps violate fabrication rules, and a combline bandpass filter designed from scratch given only target S-parameters.

Probabilistic super-resolution of high-dimensional spatial fields using diffusion models is often computationally prohibitive due to the cost of operating directly in pixel space. We propose PODiff, a structured conditional generative framework that performs diffusion in a fixed, variance-ordered Proper Orthogonal Decomposition (POD) coefficient space, exploiting the orthogonality of POD modes to impose an interpretable, variance-ordered latent geometry. This design enables efficient ensemble generation, preserves dominant spatial structure, and yields spatially interpretable, well-calibrated uncertainty at substantially lower computational cost. We evaluate PODiff on sea surface temperature downscaling over the West Australian coast and on a controlled advection-diffusion benchmark. PODiff achieves reconstruction accuracy comparable to pixel-space diffusion while requiring significantly less memory and producing more reliable uncertainty estimates than deterministic and Monte Carlo Dropout baselines.

Diffusion models provide a powerful generative prior for perceptual reconstruction at ultra-low bitrates, but effective video compression requires controlling the generative process using highly compact conditioning signals. In this work, we present ActDiff-VC, a diffusion-based video compression framework for the ultra-low-bitrate regime. Our method partitions videos into variable-length segments, transmits keyframes only when needed, and summarizes temporal dynamics using a compact set of tracked point trajectories. Conditioned on these sparse signals, a conditional diffusion decoder synthesizes the remaining frames, enabling perceptually realistic reconstruction under severe rate constraints. To support this design, we introduce two mechanisms: content-adaptive keyframe selection and budget-aware sparse trajectory selection, which together enable compact yet effective conditioning for generative reconstruction. Experiments on the UVG and MCL-JCV benchmarks show that ActDiff-VC achieves up to 64.6% bitrate reduction at matched NIQE, improves KID by up to 64.6% and FID by up to 37.7% at comparable bitrates against strong learned codecs, and delivers favorable perceptual rate--distortion trade-offs relative to learned and diffusion-based baselines in the ultra-low-bitrate regime.

Synthesizing longitudinal medical images at controllable disease stages while preserving patient-specific anatomy is hindered by the entanglement of pathological textures and structural features. We address this challenge for ulcerative colitis (UC) endoscopy, where severity follows a continuous ordinal progression along the Mayo Endoscopic Score (MES). Our framework, Disentangled Anatomy-Disease Diffusion (DADD), conditions a latent diffusion model on two complementary embeddings: a pretrained image encoder for patient anatomy and a separately trained ordinal embedder for cumulative disease severity. Since image embeddings inevitably capture disease information, we introduce a Feature Purifier, a cross-attention-based erasure mechanism that identifies and suppresses disease-correlated channels, yielding purified anatomical representations. These cleaned anatomy tokens and target disease tokens are injected into the denoising network via a Triple-Pathway Cross-Attention mechanism with resolution-dependent routing gates. This architecture leverages the U-Net hierarchy, in which different network depths encode global structure versus fine-grained pathological texture. Furthermore, we introduce Delta Steering, a training-free directional signal derived from the ordinal embeddings that enables explicit, single-pass control over disease transitions at inference without requiring additional forward passes. Validated on the LIMUC dataset, our approach produces high-fidelity images across all severity levels and effectively rebalances skewed class distributions, enhancing performance for downstream classification tasks. The dataset is available at zenodo.org/records/5827695 and the code base at github.com/umutdundar99/progressive-stable-diffusion

Accelerated magnetic resonance imaging (MRI) enabled by the training of deep learning (DL)-based image recon. models requires large and diverse raw k-space datasets. In most clinical MRI applications, due to storage and patient privacy concerns, raw k-space data is discarded and magnitude-only images are the only component saved. Consequently, a large portion of the DL-based MRI recon. literature has either relied on small training datasets or has used one of the few available open-source k-space datasets. At the same time, the growing number of anonymized magnitude-only image registries/databases motivates the development of techniques that can use them as training datasets for generalizable DL-based recon. models. Here we propose to address this challenge by employing a generative approach based on conditional score-based diffusion models (SBDMs): given a magnitude-only MR image, it synthesizes a phase map (in the image domain) that realistically corresponds to the magnitude-only image. We evaluate its generative capabilities in a downstream DL-based recon. task whereby a large k-space dataset is generated by combining the SBDM-synthesized phase-maps and the corresponding magnitude-only images, and this k-space dataset is then used to train a DL model for accelerated MRI recon. We compare the performance of the resulting DL model versus those trained according to (a) a naive approach that uses smooth phase, (b) a k-space training dataset generated using synthesized phase maps derived from a generative adversarial network, and (c) the ground truth k-space data. Our results suggest that the DL model trained from SBDM-synthesized k-space data outperforms the other approaches in terms of quantitative metrics as well as qualitatively observed recon. fidelity, i.e., whether the reconstructed images include erroneous or hallucinated features that could adversely impact diagnostic accuracy.

Suspect face generation remains a technical challenge in crime investigations. Traditional sketch-drawing workflows suffer from low efficiency and quality, while diffusion-based approaches still face intrinsic limitations on conditional ambiguity for text-to-image models and sampling variance for one-shot generation. We proposed IdentiFace, a novel diffusion-based framework for identifiable suspect face generation, which addressed these issues through (1) multi-modal input design to strengthen conditional control, and (2) an iterative generation pipeline enabling identifiable feature adjustment. We additionally contributed a facial identity loss and two task-specific datasets. Comprehensive experiments on synthetic datasets and in real-world scenarios indicate that IdentiFace achieves superior performance over existing methods, especially in terms of identity retrieval, and shows strong potential for practical applications.