Conditional Generative Modeling

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29 papers in the last four weeks, up 142% on the four weeks before. 0.3% of all new papers.

Jul 13Week of Sep 28

Latest papers 258

Sep 15, 2026cond-mat.mtrl-sci

Robust and Efficient AI Frameworks for Scalable Material Design and Property Prediction

This thesis develops robust and efficient AI frameworks for accelerating crystalline materials discovery by addressing both major stages of the materials-design pipeline: crystal property prediction and crystal structure generation. Motivated by the high computational cost of Density Functional Theory (DFT) and the limited availability of labeled materials data, the thesis explores graph representation learning, pretraining, multimodal learning, and generative modeling for scalable materials design. For property prediction, the thesis first introduces CrysXPP, which learns transferable crystal representations through unsupervised graph autoencoding, reducing dependence on large property-labeled datasets. It then proposes CrysGNN, a large-scale self-supervised graph pretraining framework that captures atomic connectivity, chemical attributes, and global structural information and transfers this knowledge to downstream property predictors through knowledge distillation. CrysMMNet further enriches crystal representations by jointly modeling graph structure and textual descriptions, thereby incorporating both local chemical and global structural knowledge. For crystal generation, the thesis introduces TGDMat, a text-guided joint diffusion framework that jointly models lattice parameters, atomic types, and atomic coordinates while incorporating textual structural knowledge during denoising. This enables the generation of more valid and stable periodic materials while also supporting conditional generation from natural-language descriptions. Overall, the thesis establishes a unified AI-based framework for data-efficient property prediction and controllable crystal generation, demonstrating how graph learning, multimodal representations, and generative models can reduce computational cost and improve the scalability of materials

Kishalay Das

Graph SSL Materials Property Prediction Crystal Structure Generation Multimodal Graph Learning Conditional Generative Modeling

Sep 14, 2026cs.LG

Representing Clinical Conditions on Vital Signs from Healthy Individuals using Latent Modeling

Machine learning can be crucial to help scale complex signal processing applications in scenarios such as healthcare. However, these machine learning models need rich datasets to be trained and there are often cases where it is not possible to access representative datasets. In this paper, we propose a deep generative model based on conditional variational autoencoders with the objective of augmenting the vital signs of healthy individuals in a way that mimics the patterns of a certain clinical condition. More specifically, we use a publicly available ICU (Intensive Care Unit) dataset to train our model and then evaluate it using the vital data that we have collected from healthy individuals. Our results demonstrate that the proposed model can not only learn the underlying dynamics of the ICU data but, more importantly, can reshape our collected data from healthy individuals in a way that is aligned with the vital signs of a certain clinical condition. We propose a distance metric that shows how our model can generate samples that are more aligned with the intended clinical labels when compared to the tested baselines.

Rafael Pina, Varuna De Silva, Mindula Illeperuma

Institute for Digital Technologies Loughborough University London London, United Kingdom

Synthetic Data Augmentation Time Series Generation Time Series Data Augmentation Conditional Generative Modeling

Sep 14, 2026cs.LG

Ensemble-Conditioned Molecular Design

Molecular design is typically approached as a problem of finding molecules which can adopt a single bioactive conformation. In reality, molecules occupy a distribution over conformations, and many of the properties which determine whether a candidate is viable depend on that distribution rather than on any single conformer. We reframe molecular design as an optimisation of both the modes and properties of molecules' conformational ensembles, where modes can be represented as shapes, pharmacophore profiles or protein pockets, and properties are aggregate scalars computed over the whole distribution. To realise this we introduce ensemble-conditioned guidance, a framework which conditions 3D molecular generative models on both axes simultaneously. Mode conditions are composed adaptively at inference by combining the vector fields produced under each condition. Conditions may be targeted or avoided, mixed across modalities and combined in arbitrary numbers, allowing a wide range of design tasks to be expressed with a single trained model. We introduce adaptive symmetry learning to allow conditions from different reference frames to be composed, and extend our generative framework to enable flexible-size generation. We evaluate on new benchmarks for multi-mode conditioning and ensemble property optimisation, and apply the framework to two practical drug discovery tasks, dual-target binder design and active-state-selective agonist design, where in both cases conditioning on the additional state improves the desired outcome over single-state conditioning.

Ross Irwin, Alessandro Tibo, Jon Paul Janet +1

Molecular AI Discovery Sciences, R&D AstraZeneca Gothenburg, Sweden · Department of Computer Science and Engineering Chalmers University of Technology and University of Gothenburg Gothenburg, Sweden

Molecular Optimization Structure-Based Drug Design 3D Molecular Generation Molecular Generation Conditional Generative Modeling

Sep 9, 2026cond-mat.mtrl-sci

uFlowCSP: Crystal Structure Prediction using Mean flow generative models

Crystal structure prediction (CSP) is fundamental to computational materials discovery. Generative models including CDVAE, DiffCSP, FlowMM, and CrystalFlow learn stable-crystal distributions directly, but diffusion and flow-matching inference requires tens to thousands of sequential network evaluations per candidate. We introduce uFlowCSP, a MeanFlow-based CSP model that learns the average, rather than instantaneous, probability-flow velocity. It generates a complete structure in one to five evaluations, delivering 5x-58x faster inference with equal or better performance. A chemistry- and symmetry-aware Transformer uses canonical atom ordering, global composition, and per-token chemistry embeddings. A coarse crystal-system token is used only during training; it provides additive gains, particularly improving space-group agreement despite being absent at inference, which remains formula-only. On MP-20 with 20 candidates per target, one step matches CrystalFlow (78.38% vs. 78.34%) with 100x fewer evaluations and about 10x lower wall-clock time. Five steps reach 83.64%, exceeding CrystalFlow (78.34% at 2,000 evaluations) and DiffCSP (77.93% at about 20,000), while using 20x fewer evaluations. uFlowCSP generates 10,000 structures in 0.39-1.31 minutes, versus 6.5 for CrystalFlow and 76.1 for DiffCSP. Under CSPBench's energy-ranked top-five structure-and-space-group criterion, five-step uFlowCSP reaches 72%/72%/65% structure, space-group, and consensus match rates. CrystalFlow reaches 78%/73%/68% at 100 steps but falls to 49%/32%/31% at five. Thus, uFlowCSP improves accuracy per network evaluation, not merely peak accuracy.

Sourin Dey, Dipannoy Das Gupta, Lai Wei +2

Department of Computer Science and Engineering University of South Carolina Columbia, SC 29201 · Department of Computer Science and Cybersecurity University of North Georgia Columbia, SC 29201

Crystal Structure Prediction One-Step Generative Modeling Crystal Structure Generation Flow-Based Generative Modeling Conditional Generative Modeling Computational Materials Science

Sep 8, 2026cs.LG

NOAH: Learning the Full Patient Journey. A Longitudinal Multimodal Time-Aware Model for Representation and Forecasting

The digitization of healthcare has generated vast, longitudinal, and multimodal patient records over a lifetime, yet fully exploiting these data to represent and predict patient state trajectories remains a critical challenge. Current AI models often struggle to capture the complex, irregular temporal dynamics and inherent stochasticity of real-world multimodal patient data. Existing AI approaches for modeling longitudinal patient records are predominantly discriminative, limited to a few modalities, constrained by closed categorical vocabularies, treating time as a monotonic inductive bias, or they are limited in forecasting future patient states. We introduce NOAH, a time-aware, task-agnostic, generative transformer model representing and forecasting the full multimodal patient journey. NOAH features a novel bidirectional time integration and a variational latent space to capture the continuous evolution of patient states and the stochasticity of clinical trajectories. Built from over 559 million clinical events from 431,000 hospital visits of 299,000 patients across the MIMIC dataset family, NOAH natively processes medical images, time-series and numeric signals, categorical events, as well as structured and unstructured clinical records. NOAH is the first truly holistic generative model in its field, enabling autoregressive forecasting with optional time control, zero-shot classification, and counterfactual intervention simulation. It generates highly informative and predictive patient state representations that demonstrate strong performance in probing for clinical outcomes, 15 ICD chapters, and 29 comorbidities, as well as in time-to-event prediction. Seamlessly handling diverse modalities and complex temporal dynamics, NOAH provides a versatile, task-agnostic, scalable foundation for intelligent predictive systems in personalized clinical care and digital medicine.

Tobias Susetzky, Raphael Rehms, Dmitrii Seletkov +5

Chair for AI in Healthcare and Medicine, TUM University Hospital and Technical University of Munich (TUM), Munich, Germany · Institute for Diagnostic and Interventional Radiology, TUM University Hospital, Munich, Germany · Munich Center for Machine Learning (MCML), Munich, Germany +3

Irregular Time-Series Modeling Clinical Prediction Multimodal Foundation Models Longitudinal EHR Modeling Conditional Generative Modeling

Sep 7, 2026cs.AI

MedFlow: Class-Aware Multi-Scale Generation for Medical Time-Series Synthesis

Synthetic medical time-series generation can alleviate data scarcity and support the development of reliable clinical prediction models. However, existing methods mainly focus on matching the overall distribution and temporal dynamics of real data, which does not necessarily ensure strong downstream utility on imbalanced medical datasets. Clinically informative patterns often occur at heterogeneous temporal scales, while rare minority-class characteristics can be obscured by dominant population patterns. To address these challenges, we propose MedFlow, a class-aware multi-scale flow matching framework for medical time-series synthesis. MedFlow employs a vector-quantized multi-scale tokenizer to represent medical sequences at complementary temporal resolutions, capturing both coarse clinical trends and fine-grained dynamics. We further introduce Token Marginal Guidance, which incorporates class-conditional token statistics directly into the flow matching process to steer generation toward class-specific regions of the learned tokens. This mechanism strengthens minority-class patterns, while preserving the global and tail distributions of real data. Experiments on four public datasets covering electronic health records, EEG, and ECG signals demonstrate that MedFlow consistently outperforms recent state-of-the-art diffusion-based baselines across downstream prediction tasks. On average, it improves AUPRC by 5.8%, reduces Context-FID by 88.6%, and achieves 3.8

\times

higher sampling throughput.

Yanhao Huang, Shibo Feng, Wanjin Feng +2

Shanghai Jiao Tong University · Nanyang Technological University · Tsinghua University

Flow Matching Synthetic Data Generation Time Series Generation Conditional Generative Modeling

Sep 1, 2026cs.LG

OutageDiT: A Generative Foundation Model for Power Outage Forecasting and Scenario Simulation

Power-outage planning requires scenarios before an event occurs. These scenarios must represent uncertainty in magnitude, timing, and duration while preserving temporal dependence. However, severe events are rare, and data from any single region contain few examples of extreme outage and restoration patterns. To address this challenge, we introduce OutageDiT, a foundation model for generating seven-day outage trajectories at quarter-hour resolution, trained on outage and weather records across the United States. Specifically, a condition encoder processes the historical context and known future covariates once per forecast, and a shallow flow decoder reuses the resulting horizon-aligned states to generate complete trajectories. The resulting samples support point forecasting, uncertainty quantification, and conditional event simulation within one deep generative model. Across outage forecasting benchmarks, OutageDiT improves forecast accuracy and scenario quality over strong baselines and supports zero-shot transfer to held-out regions. Together, these results position conditional outage simulation as a bridge from outage forecasting to operational planning under uncertainty.

Yunqin Zhu, Feng Qiu, Yao Xie

H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology · Argonne National Laboratory

Conditional Generative Modeling Time-Series Foundation Models Probabilistic Time Series Forecasting Power Systems

Sep 1, 2026cond-mat.mtrl-sci

FrOGS: Discrete Neural Sampler for Independent Alloy Configurations Across Chemical Conditions

Predicting the thermodynamic properties of an alloy requires sampling its configurations across many chemical conditions and recovering free energies on a common absolute scale. Markov chain Monte Carlo (MCMC) is the standard tool, but it requires separate simulations at different conditions, and auxiliary free-energy methods such as thermodynamic integration are used to place results on a common absolute scale. Modern discrete neural samplers typically use reverse KL divergence as the objective and can be mode-seeking or biased. We present Free energy Offering Generative Sampler (FrOGS), a hybrid discrete neural sampler that couples an autoregressive model to a continuous-time Markov chain (CTMC) to be trained jointly under a single shared loss. FrOGS draws i.i.d. configurations, returns an unbiased estimate of the partition function, and gives consistent estimates of thermodynamic observables. We train a single model across a wide range of chemical conditions to produce estimates on a common absolute free-energy scale. FrOGS matches exact finite-size results on the 2D Ising model and reference phase diagrams for AgPd and CuAu, without mode collapse. We additionally compare to SEGAL, a published autoregressive baseline, and find that only FrOGS recovers the stability range of the CuAu

_3

phase.

Kyucheol Min, Elyssa Hofgard, Tess Smidt

Massachusetts Institute of Technology Cambridge, MA 02139

Free Energy Calculation Materials Science Conditional Generative Modeling

Sep 1, 2026stat.ML

On the Reliability of Generative Augmentation: A Wasserstein-Based Theoretical and Empirical Study

Generative data augmentation is widely used to mitigate class imbalance, yet its theoretical effect on downstream generalization remains poorly understood. In this work, we develop a statistical framework for conditional generative augmentation and analyze its impact on classification risk. We formalize augmentation as a distribution-mixing process and show that the resulting risk distortion is controlled by both the augmentation strength and the class-conditional Wasserstein discrepancy between real and generated distributions. We further derive a capacity-dependent generalization bound based on Rademacher complexity, revealing an explicit trade-off between hypothesis complexity, augmentation intensity, and generative fidelity. Empirically, we evaluate the framework on binary and multiclass imbalanced classification tasks using Conditional GAN and Conditional WGAN-GP augmentation. Across datasets, CWGAN-GP consistently achieves lower Wasserstein discrepancies than CGAN, indicating improved distributional fidelity. However, improved fidelity does not necessarily translate into superior classification performance, with classical oversampling methods often remaining competitive. These findings support the central theoretical prediction that augmentation reliability is governed by distributional approximation error rather than predictive performance alone. Overall, this work establishes generative augmentation as a distributional perturbation process whose reliability can be quantified through Wasserstein-based measures and supported by finite-sample generalization guarantees. The proposed framework provides a principled foundation for evaluating synthetic data quality beyond classification accuracy alone.

Chathurika S Abeykoon, Mathias Nthiani Muia, Mallory Goldstein

Class-Imbalanced Learning Synthetic Data Augmentation Conditional Generative Modeling Generative Adversarial Networks Generalization Bounds

Sep 1, 2026cs.LG

When Metropolis and Hastings Meet Bradley and Terry: Exact MCMC From Preference Voting

Sampling from distributions conditioned on desired semantic properties is an emerging challenge in modern generative modeling. Metropolis-Hastings (MH) provides a principled route to conditional sampling, but requires access to exact pointwise target-density evaluations, which are not available in generative settings. Meanwhile, pairwise comparisons by humans or model "judge" are highly accessible and have proved valuable across diverse applications. We introduce Pref-MH, a general exact MH sampler for judge-induced conditional distributions using only stochastic binary pairwise comparisons. Our key observation is that the MH unnormalized density ratio matches the preference odds of the Bradley-Terry (BT) choice model. The central challenge is that while MH requires precise ratio computation, BT judges provide only sampled binary feedback. To this end, we develop a valid accept/reject rule whose resulting Markov chain provably converges to the target distribution. We further show that, for a fixed proposal kernel and budget, Pref-MH is optimal in the Peskun-Tierney sense among this class of exact reversible acceptance rules. Experiments on text generation and molecular design with LLM judges, as well as image generation with VLM judges, demonstrate that Pref-MH provides a practical and flexible approach to conditional sampling when comparative feedback is relatively easy to obtain.

Ariel Smogorghevski, Nir Rosenfeld, Yaniv Romano

Department of Data and Decision Sciences, Technion – Israel Institute of Technology · Department of Computer Science, Technion – Israel Institute of Technology · Department of Electrical and Computer Engineering, Technion – Israel Institute of Technology

Markov Chain Monte Carlo Markov Models Conditional Generative Modeling

Sep 1, 2026cs.LG

Conditional Flow Matching for ML-Based Inverse Design Problems

Engineering inverse design is often limited by the high computational cost of iterative solvers for optimization problems constrained by partial differential equations (PDEs) and by their sensitivity to initialization. Deep generative models can produce candidate designs without rerunning the simulator at inference time. Generative adversarial networks (GANs) sample in one forward pass, whereas diffusion models require iterative reverse-time integration. In this work, we add conditional flow matching (CFM) to EngiOpt and compare it with a conditional diffusion model and a conditional generative adversarial network (cGAN) on structural (beams2d) and thermal (heatconduction2d) benchmarks from EngiBench using the same downstream optimization protocol. We use cumulative optimality gap (COG) and final optimality gap (FOG) as the primary metrics for evaluating the generated designs as warm starts for gradient-based refinement. On the evaluated EngiOpt implementations and two EngiBench tasks, CFM achieves the lowest measured COG, FOG, maximum mean discrepancy (MMD), and volume-fraction deviation on both tasks. CFM has mean volume-fraction deviations of 0.4% and 1.0% on beams2d and heatconduction2d, respectively, compared with 3.8% and 11.2% for diffusion. At Euler s = 16, CFM achieves 53.2 samples/s on beams2d, about 66 times the measured throughput of the evaluated diffusion baseline using 1000 network evaluations under the same timing protocol, with COG 1.182 +/- 3.126, compared with 1.173 +/- 3.100 for Euler s = 32. Across the two tasks, CFM produces warm starts with lower measured COG than both baselines and uses fewer network evaluations than diffusion.

Juliana Felder, Milad Habibi, Soheyl Massoudi +1

ETH Zürich · University of Maryland, College Park

Conditional Flow Matching Constrained Optimization Flow-Based Generative Modeling Conditional Generative Modeling Inverse Design

Aug 31, 2026cs.LG

Language-Informed Flow Matching for Trend-Guided Structure-Based 3D Molecular Generation

Structure-based drug design (SBDD) requires ligands that satisfy both 3D target affinity and 1D chemical validity. Existing controllable generation methods often rely on task-specific fine-tuning or externally imposed sampling-time guidance, adding cost and potentially conflicting with evolving 3D geometric constraints. We propose LiFT, a language-informed cross-modal framework built on Flow Matching for trend-guided 3D molecular generation across both de novo design and scaffold hopping. LiFT uses a "Sense-Evolve-Assemble" agent to generate target-aware SMILES as intermediate chemical conditions, from which a pre-trained chemical foundation model extracts continuous semantic priors. These priors are integrated into geometric generation through a lightweight semantic projector with zero-initialized adaptive normalization for stable cross-modal conditioning. We further introduce a Self-Conditioned Decoupled Router (SCDR), which modulates the velocity field according to intermediate structural states during ODE integration. Experiments on Cross-Docked2020 show that LiFT achieves competitive distribution matching while improving medicinal chemistry metrics and maintaining competitive structural validity under task-steering settings without additional generator fine-tuning. Our results suggest that language-derived chemical priors provide effective trend-level guidance for 3D molecular generation. Code and released artifacts are available at https://github.com/kasurl/LiFT.

Tianyu Gao, Zhikai Su, Jiashu Li +5

1City University of Hong Kong · 2The University of Hong Kong · 3Stanford University

Flow Matching Structure-Based Drug Design 3D Molecular Generation Molecular Generation Conditional Generative Modeling

Aug 31, 2026cs.SD

Decoupled Latent Flow Matching for Few-Step Joint Vocal-Accompaniment Separation

Generative modeling provides a flexible way to model mixture-conditioned source distributions, but iterative diffusion and flow matching models are costly for long music signals. This paper studies joint vocal-accompaniment separation through latent flow matching, where a pretrained variational autoencoder (VAE) maps mixtures and sources into a compact latent space and a flow matching model generates vocal and accompaniment latents jointly. The proposed framework decouples semantic separation from acoustic velocity prediction through a Separation Encoder and a Velocity Decoder. To reduce sampling cost, we further apply latent adversarial post-training inspired by Flow2GAN for few-step generation. Experiments show that latent adversarial refinement can improve perceptual and separation metrics under a reduced sampling budget.

Lishi Zuo, Youzhi Tu, Lu Yi +4

Dept. of Electrical and Electronic Engineering, Hong Kong Polytechnic University, Hong Kong SAR, China

Flow Matching Flow-Based Generative Modeling Audio Source Separation Conditional Generative Modeling

Aug 30, 2026cs.LG

Diffusion-Based Inverse Design of Dielectric Resonator Metasurfaces for Shaping Smart Electromagnetic Environments

Future wireless systems are expected to transform the surrounding space from a passive propagation medium into a smart electromagnetic environment, where engineered surfaces control wave propagation, support wireless sensing, and create programmable electromagnetic fingerprints. A key challenge in realizing this vision is the inverse design of metasurfaces for tailored electromagnetic propagation. While forward analysis evaluates the response of a known geometry, the inverse task starts from a prescribed scattering signature and seeks a physically realizable structure that produces it. This inverse task is inherently nonlinear and often high-dimensional, while candidate solutions may be non-unique and provide no direct indication of practical realizability. Here, we introduce a conditional diffusion framework for inverse design of dielectric resonator metasurfaces from target angular scattering patterns. Trained on T-matrix simulated geometry-response pairs, the model learns a conditional distribution of geometries instead of a deterministic mapping, enabling multiple candidate designs for the ill-posed inverse problem. The best generated metasurface achieves a mean percentage error of 1.39%, outperforming CMA-ES optimization (4.1% after 10 h) while requiring only about one minute for after-training inference. The model also produces lower error distributions than deterministic neural baselines for out-of-distribution spectra, highlighting the potential of diffusion models for efficient metasurface design.

M. Tsukerman, K. Grotov, D. Vovchuk +1

Conditional Generative Modeling Inverse Design Inverse Problems Diffusion Models

Aug 13, 2026cs.LG

FlowLOB: Efficient and Controllable Limit Order Book Generation with Flow Matching

Limit order book (LOB) simulators are most useful to practitioners when they combine realistic market dynamics, computationally efficient sampling, controllable scenario generation, and the ability to generalize beyond the instruments seen during training---properties that existing agent-based and deep generative simulators provide only partially. We present \textbf{FlowLOB}, a conditional \textbf{flow}-matching generator of \textbf{LOB} trajectories, trained on multiple Hong Kong Exchange (HKEX) symbols at three sampling frequencies (

0.1

s,

1

s,

10

s) in tick-relative representation that transfers to unseen instruments. Because flow and diffusion models admit a common formulation, we train both with identical data, architecture, and budget, and sample both through the same fixed-step ODE solvers, yielding a controlled comparison of sampling efficiency and fidelity. Flow matching attains its best quality with only

10

ODE-solver steps, whereas diffusion needs many more function evaluations to approach the same fidelity. At this efficient operating point, FlowLOB improves realism over baselines, two learned and two agent-based models, in most distributional metrics at the two finer sampling frequencies. We evaluate counterfactual controllability with a distributional test that asks whether changing a scenario condition moves the generated statistic toward the corresponding real tail regime; FlowLOB satisfies this criterion in most tested settings. Both realism and control effects transfer zero-shot on a held-out symbol. We additionally conduct ablation studies on the network architecture and the learning rate.

Zhuohan Wang, Andreea Bacalum, Ollie Olby +2

Joint affiliation with King’s College London · Simudyne United Kingdom · King’s College London United Kingdom

Flow Matching Flow-Based Generative Modeling Conditional Generative Modeling

Aug 13, 2026physics.ins-det

Fine-tuned Normalizing Flows for ALICE Zero Degree Calorimeter Fast Simulation

Simulating the ALICE Zero Degree Calorimeter (ZDC) neutron detector responses at the LHC is computationally expensive, requiring complex Monte Carlo chains. We develop a generative surrogate, focusing on Normalizing Flows (NFs). Through transfer learning, we pre-train on the full imbalanced dataset and fine-tune specialized models for different particle types (

γ

,

n

,

Λ

,

K_S^0

,

Σ^+

) using two gradual-unfreezing schemes. As standard ZDC metrics like Wasserstein distance overlook conditional structure, we introduce refined metrics: conditional weighted MAE, dispersion ratio, and Jaccard co-activation error, that better capture physics-relevant input-output dependencies and response variability. Our ensemble of fine-tuned models achieves a Wasserstein distance of

1.61 \pm 0.02

, outperforming baselines across all metrics. This work provides a generalizable NF-based framework for LHC detector simulation, combining NFs, conditional fine-tuning, and physics-motivated evaluation.

Emilia Majerz, Jacek Otwinowski, Witold Dzwinel +1

AGH University of Krakow, Poland · The Henryk Niewodniczański Institute of Nuclear Physics, Polish Academy of Sciences

Neural Surrogate Modeling Normalizing Flows High-Energy Physics Conditional Generative Modeling

Aug 10, 2026cs.LG

Flow-based conditional cardiac anatomy generation for virtual cohorts

Cardiac digital twin research is moving from subject-specific anatomical replicas toward virtual cohorts that represent clinically relevant population subgroups. Yet access to representative imaging-derived anatomy datasets remains limited by cohort size, subgroup sparsity, and data-sharing constraints. Conditional generative models could help address this gap, but virtual cohorts are useful only if they preserve realistic, metadata-dependent anatomical variability. Existing cardiac anatomy generators largely rely on conditional variational autoencoders (cVAEs), which couple representation learning and metadata conditioning through a shared regularized latent prior. We introduce CAN-FLOW, a two-step Conditional ANatomy generation framework based on normalizing FLOWs that first learns geometry-only latent representations of diffeomorphic cardiac shape momenta and then models their sex-, age-, and body-mass-index-dependent distribution with a conditional normalizing flow. We trained CAN-FLOW on 2,208 healthy UK Biobank subjects and compared it with cVAEs across regularization strengths. CAN-FLOW generated plausible stochastic biventricular anatomies that better reproduced clinical phenotype distributions, metadata-dependent trends, subgroup variability, point-cloud coverage, and high-dimensional shape variability. Together, these results establish CAN-FLOW as a shareable framework for generating realistic, stochastically varying, metadata-conditioned biventricular anatomies for virtual cohort construction and in silico clinical trial workflows.

Konstantinos Kevopoulos, Beatrice Moscoloni, Benjamin Alheit +4

Dept. BioMechanical Engineering, Delft University of Technology, Delft, The Netherlands · Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA · BioMMeda – Institute for Biomedical Engineering and Technology, Ghent University, Ghent, Belgium +2

Normalizing Flows 3D Medical Imaging Synthetic Data Generation Conditional Generative Modeling

Aug 10, 2026cs.CV

ControlRadio: Prompt-Driven Controllable Diffusion for Cross-Modal Radio Map Generation

Radio maps describe how wireless signals propagate across space and are essential for wireless communication, sensing, and network planning. However, constructing accurate radio maps traditionally requires either dense measurements or computationally expensive physical simulations, which limits scalability and real-time deployment. Recent advances in generative artificial intelligence offer a promising alternative, but existing approaches lack fine-grained control and physical consistency when applied to real-world wireless environments. Here we present \textbf{ControlRadio}, a controllable generative framework that produces radio maps from natural-language descriptions and environmental layouts, including building structures and transmitter locations. Joint semantic and spatial conditioning enables interpretable, propagation-plausible generation, while a controlled latent prior and layout-aware conditioning improve stability and structural consistency. Extensive experiments demonstrate that ControlRadio achieves state-of-the-art accuracy and strong generalization across diverse urban scenarios, while reducing computation time by more than four orders of magnitude compared with conventional simulation-based methods. Such results suggest a new paradigm for scalable and controllable wireless environment modeling, with broad implications for next-generation communication systems and data-driven radio sensing.

Kangjun Liu, Xiying Pan, Shuhang Zhang +3

Pengcheng Laboratory, China · South China University of Technology and the Pengcheng Laboratory, China · Peking University, China +2

Wireless Communications Generative Modeling Radio Propagation Modeling Conditional Generative Modeling Diffusion Models

Aug 8, 2026cs.CV

Tropical Cyclone Forecasting via Latent Rectified Flow using Satellite Imagery and Atmospheric Fields

Tropical cyclones are growing more destructive in a changing climate, and efficient forecasting of their structure and track has become a necessity. Deep generative models promise an alternative to computationally expensive numerical weather prediction (NWP), yet current systems produce either satellite imagery or atmospheric fields, never both; they need many sampling steps, putting them out of reach of modest hardware; and their storm tracks come from regression heads with no physical link to the generated atmosphere. This work presents a single-pass model that jointly forecasts GRIDSAT-B1 infrared imagery and four ERA5 atmospheric fields (U-wind, V-wind, air temperature, and surface pressure) out to nine hours. A five-channel variational autoencoder compresses each 5 x 256 x 256 frame to a 4 x 64 x 64 latent, and a conditional rectified-flow UNet with a factorized temporal-attention module predicts the next three frames from three past frames, their best-track coordinates, and timestamps. The model is then reward-fine-tuned (DRaFT) against a differentiable track error derived from the predicted winds through a steering-flow calculation. On held-out 2022 storms the model reaches 16.35 dB PSNR and 0.759 SSIM, ahead of a reproduced cascaded-diffusion baseline at every lead time (+0.84 dB at +9 h) while sampling ~30x faster (56 ms vs. 1673 ms). Track error at +9 h is 62.4 km, 15% below the baseline, and a reward fine-tuning study demonstrates a further 8-11% track-error reduction across sampler budgets.

Meheru Zannat, Sk. Md. Masudul Ahsan

Department of Computer Science and Engineering Khulna University of Engineering & Technology Khulna 9203, Bangladesh

Rectified Flow Spatiotemporal Forecasting Conditional Generative Modeling Weather Forecasting

Aug 7, 2026cs.CV

CosmosAlign: Adapting a World Foundation Model for Generative Traffic Video Forecasting

Generative traffic video forecasting aims to synthesize long-horizon, temporally coherent future videos of traffic scenes from a short observation history and textual descriptions. In this paper, we present CosmosAlign, a generative traffic video forecasting framework built upon the pretrained Cosmos3-Nano world foundation model. Our approach is motivated by the observation that successfully adapting large pretrained world models to downstream forecasting tasks depends primarily on distribution alignment rather than increased model capacity. To this end, we propose a two-stage LoRA adaptation strategy that first aligns the conditioning-mode distribution with the target forecasting task, and then aligns the training captions with the model's native structured prompting interface through an LLM-based re-captioning pipeline. During inference, we further improve prediction quality using a fully training-free procedure consisting of consensus-based medoid sample selection and motion-adaptive blending of static scene regions. CosmosAlign achieves a final score of 76.49 on the AI City Challenge 2026 Track 5 benchmark, ranking first on the final leaderboard. Our code is publicly available at https://quangminhdinh.github.io/CosmosAlign/.

Quang Minh Dinh, Tuan Kiet Doan

Simon Fraser University, Burnaby, BC, Canada · Institut Polytechnique de Paris, Palaiseau, France

Long-Horizon Video Generation Vision Foundation Model Adaptation Traffic Forecasting Conditional Generative Modeling Temporal Consistency in Video Generation

Aug 7, 2026eess.IV

Knowledge-Guided 3D CT Generation: A Conditioning-Centric Taxonomy

Controllable generation guided by external knowledge is a key requirement in modern generative deep learning applications, enabling the synthesis of samples with explicit constraints on semantic content, structural properties, and variability. In 3D Computed Tomography (CT), such control is essential for clinical applications, including data augmentation, privacy-preserving data sharing, and the simulation of specific anatomical or pathological scenarios. While research on conditional 3D CT generation has expanded rapidly, the diversity of existing approaches makes systematic comparison difficult and obscures fundamental design choices. In this survey, we propose a conditioning-centric taxonomy that organizes the literature along three orthogonal dimensions: the type of external knowledge (K), the knowledge integration paradigm (I), and the generative architecture (A). This factorization defines an explicit design space (K x I x A) that provides a unified perspective on prior work. Using this framework, we systematize existing methods, identify dominant trends and recurring design patterns, and highlight underexplored regions of the design space that point toward promising directions for future research.

Francesca Pia Panaccione, Eugenio Lomurno, Matteo Matteucci

Department of Electronics, Information, and Bioengineering Politecnico di Milano

3D Medical Imaging Computed Tomography Conditional Generative Modeling

Aug 6, 2026cs.LG

ED-CSP: Crystal Structure Prediction from Electron Diffraction

Recovering a periodic 3D crystal structure from sparse, unindexed electron diffraction (ED) observations is a challenging generative inverse problem. Existing ED-based learning methods mainly predict crystallographic labels, reconstruct structures from indexed reflections, or retrieve candidates from finite structure libraries. Here, we introduce ED-CSP, a machine learning framework that predicts crystal structures from chemical composition, atom count, and multiple detector-plane ED spot sets. ED-CSP combines a relational set encoder, permutation-invariant multi-view aggregation, and a periodic flow generator to jointly predict lattice parameters and fractional atomic coordinates. To train the model, we construct ED-CS, a dataset of 4.85 million simulated multi-view ED crystal structures, deduplicated across seven materials repositories and filtered to exclude CHILI-100K overlaps. On 2,075 held-out CHILI-100K materials, ED-CSP trained only on CHILI achieves a structural match rate of 57.49% MR@5, outperforming PXRDGen (52.92%), a state-of-the-art crystal structure prediction model conditioned on powder X-ray diffraction. Scaling training data further improves performance: initializing from a one-million-structure precursor raises MR@5 to 66.27%. On 1,024 compositions absent from the training retrieval library, the model still achieves 53.52% MR@5, demonstrating true generative capability beyond exact-formula retrieval. Replacing target ED observations with diffraction from non-isomorphic structures of identical composition decreases MR@5 by 22.09 percentage points, confirming that predictions depend on the input diffraction patterns rather than composition alone. ED-CSP and ED-CS establish a benchmark for generative crystal structure prediction from sparse ED observations and provide a foundation for future transfer to experimental data.

Germain Poloudenny, Yaël Frégier, Arnaud Demortière

Laboratoire de Mathématiques de Lens (LML), UR 2462, Université d’Artois, Lens, France · Laboratoire de Réactivité et de Chimie des Solides (LRCS), CNRS UMR 7314, UPJV, Amiens, France · Réseau sur le Stockage Electrochimique de l’Energie (RS2E), CNRS FR 3459, Amiens, France +1

Crystal Structure Prediction Crystal Structure Generation Conditional Generative Modeling Computational Materials Science

Aug 6, 2026cs.CV

Energy-Guided Flow Matching

Pixel-space generative models bypass lossy latent compression, yet necessitate joint learning of global structure and fine-grained details in a high-dimensional space. Standard flow matching interpolates noise toward a fixed clean-image endpoint, leaving the spectral evolution to be learned implicitly. In this paper, we introduce Energy-Guided Flow Matching(EG-FM) that explicitly models a coarse-to-fine generative trajectory by moving endpoint. Specifically, EG-FM replaces the fixed endpoint with a heat-kernel-filtered endpoint that evolves smoothly from low-frequency image to clean image. The fraction of high-frequency signal in moving endpoint is released by an image-specific energy-guided scheduling, leading to the re-targeting of velocity in flow matching. Our framework requires no adaptation of the backbone and training data, bringing negligible cost on the training and inference stages. In our experiment, EG-FM consistently achieves lower FID on the ImageNet class-conditional image generation task at

256 \times 256

with fewer epochs, reaching an FID of 1.55 at 200 epochs and 1.45 at 600 epochs. We continue training the generation task on the setting of

512 \times 512

resolution, yielding a FID of 1.58 after only 40 high-resolution adaptation epochs. Furthermore, we transfer EG-FM on text-to-image generation and achieve 0.85 on GenEval score and 83.9 on DPG-Bench. Code is available at https://github.com/ysng123/EG-FM.

Haoyang Tong, Yu He, Fang Li +6

MAIS & NLPR, CASIA · JD.com · Xi'an Jiaotong University +1

Flow Matching Conditional Image Generation T2I Generation Image Generation Flow-Based Generative Modeling Conditional Generative Modeling

Aug 6, 2026cs.LG

FarSky: Task-Aware Latent-Space Coupling for Generative Intra-Hour Solar Forecasting

Accurate solar irradiance forecasting is essential for the reliable integration of photovoltaic power into modern electricity grids. All-sky imagers (ASI) provide high-resolution observations of clouds, making them well suited for intra-hour forecasting. Recent deep learning approaches have substantially improved forecast accuracy but are often limited by deterministic predictions and a reduced capability to anticipate ramp events. This work proposes FarSky, a generative forecasting framework that leverages latent-space coupling to learn task-aware representations of sky images. A multi-task autoencoder first learns a shared latent representation for image reconstruction and irradiance estimation. A latent diffusion model then generates future latent states conditioned on recent observations, from which irradiance forecasts are directly decoded. Probabilistic forecasts are inherently obtained through stochastic sampling. The framework is developed using a multi-year ASI dataset acquired at the Plataforma Solar de Almería, Spain, and evaluated on two independent test datasets against persistence, state-of-the-art end-to-end, and generative forecasting approaches. FarSky achieves the best overall deterministic and probabilistic forecasting performance, improving forecast skill by up to 11 percentage points. Furthermore, it substantially improves ramp event detection over existing methods, achieving F1-scores above 60%. These results demonstrate the potential of combining generative models with task-aware latent-space coupling for solar forecasting.

Yann Fabel, Bijan Nouri, Milon Miah +4

1DLR, Institute of Solar Research · 2RWTH Aachen University · 3CIEMAT, Energy Department, Renewable Energy Division

Time Series Forecasting Solar Power Forecasting Conditional Generative Modeling Probabilistic Time Series Forecasting

Aug 5, 2026cs.LG

Marginal Matching Does Not License Factorized Sampling: Auditing Conditional Style Leakage in Factorized Generative Models

Factorized generative models commonly regularize a latent style variable z_s by matching its marginal distribution to a fixed Gaussian prior and interpret this as evidence that the style representation is independent of class information. We show that this interpretation is incorrect. Matching only the marginal distribution places no constraint on the class-conditional distributions, allowing the latent style to remain highly predictive of the label despite appearing perfectly Gaussian in aggregate. We derive an exact decomposition showing that this mismatch is one of four conditions required for factorized sampling, and demonstrate that eliminating it is necessary but not sufficient to obtain the intended factorization. Empirically, our case-study model and four representative latent baselines achieve near-zero global MMD while still allowing a linear probe to recover class labels with 74%--100% accuracy (10% chance level). Our model reaches 99.15% clustering accuracy, whereas externally evaluated class-conditional generation succeeds only 16% of the time. This leakage remains under six independent perturbations involving model capacity, curriculum, prior geometry, and supervision across two datasets. Four mitigation strategies reduce probe accuracy to 21%--46%, although they leave within-class dependence largely unchanged. A post-hoc conditional prior improves externally evaluated class generation to 0.97 on MNIST without retraining but reaches only 0.41 on CIFAR-10, while an empirical style bank achieves 0.88 on CIFAR-10. These results demonstrate that no divergence computed solely on the marginal distribution of the style latent can certify independence from class labels, and that reporting marginal statistics alone does not verify the property commonly claimed in factorized generative models.

Duong Bach, Hai Nguyen Hong, Cuong Do

Smart Health Center (VISHC), VinUniversity, Ha Noi, Viet Nam

Disentangled Representation Learning Latent Variable Models Generative Modeling Conditional Generative Modeling

Aug 5, 2026cs.CV

CSGen: A Multi-Domain Curvilinear Structure Generation Model via Hierarchical Multimodal Diffusion

Curvilinear structure analysis is an important and fundamental task in multimedia. However, the controllable generation of images with precise curvilinear structure objects remains an open challenge. To address this, we propose CSGen, a hierarchical multimodal diffusion model that synthesizes high-fidelity images precisely aligned with multiple control conditions. The CSGen is built upon three key innovations: 1) We construct a multi-domain and multimodal dataset, including over 24K samples from 5 domains and 7 different types of annotations, to train the unified generation model. 2) We propose a novel hierarchical progressive control strategy that decouples topology clues from visual context by a phased signal injection, mitigating semantic drift while ensuring the topological integrity of sparse structures. 3) We design a sparsity-aware loss re-weighting mechanism to address the extreme sparsity of curvilinear structures, significantly enhancing the attention on thin and fragile structures during optimization. Extensive experiments demonstrate that CSGen generates images with superior structure accuracy and visual realism, significantly improving downstream segmentation performance while maintaining robustness across diverse prompts. Our results confirm CSGen as a scalable, data-centric paradigm for the analysis of complex curvilinear structures in diverse multimedia applications. Code and dataset are available at https://github.com/ShanZard/CSGen.

Zhe Shan, Ziming Yang, Lei Zhou +3

Hainan University Haikou, China · Guangdong Ocean University Zhanjiang, China

Image Generation Conditional Generative Modeling Controllable Image Generation Multimodal Diffusion Models

Aug 5, 2026cs.SD

Helping Music Co-Creation Agents 'Listen' Well: Hierarchical Self-Supervised World Models for Understanding and Generation

Collaborative music agents need internal representations rich enough to support both understanding and generation, yet flexible enough for a workflow where the human retains agency. We present a hierarchical self-supervised ``world model'' for symbolic music: a 2.55M-parameter Swin V2 encoder trained on MIDI piano-roll images with JEPA-style objectives (pitch- and time-shift equivariance, masked embedding prediction, and a distributional regularizer), using no labels and no music-theory vocabulary. Probing the frozen embeddings shows that the level at which a musical property becomes decodable tracks its musical time scale: phrase boundaries are read off the coarsest levels, note density and harmonic detail off the finest. Temporal and phrase structure emerge from the self-supervised objectives alone, while harmonic content must be asked for; a small chord-supervision head raises joint chord recovery from .18 to .54, and key detection, which is never supervised, from .16 to .70. Following the Representation AutoEncoder paradigm, a conditional flow-matching model stands in for a trained decoder, flowing in pixel space from PCA-reduced conditioning: it reproduces a target window at pixel F1

0.996

, and the same per-level conditioning dropout that controls how far variations stray also enables graphical prompting for masked inpainting with no inpainting-specific sampler. The pipeline runs on CPU producing a suggestion in

2.8

s, or

0.6

s on Apple MPS, which we demonstrate in a live interactive demo. In concert with an LLM-based brain, these capabilities supply the core of a collaborative music creation agent in service of, rather than in place of, human agency.

Scott H. Hawley

Department of Chemistry & Physics Belmont University Nashville, TN, USA

Representation Learning Self-Supervised Pre-Training Controllable Music Generation Conditional Generative Modeling Human-AI Co-Creation

Aug 4, 2026cs.SD

AI-Based Sound Effect Generation: A Narrative Review of Generative Models Across Input Modalities

Sound effects play a crucial role in conveying actions, events, and environmental cues across digital applications, often requiring a high degree of variation and contextual adaptability. Artificial intelligence (AI)-driven audio generative models are rapidly growing in popularity and have the potential to transform the way sound is synthesized and used across various applications. In response to this growing momentum, this chapter reviews and analyzes recent AI-based generative models for sound effect synthesis, with a focus on how different input modalities (text, visual, audio, and multimodal) affect the quality, controllability, and contextual relevance of the generated audio. It examines 30 peer-reviewed articles sourced from Google Scholar, IEEE Xplore, and the ACM Digital Library, exploring the evolution of AI generative models over the past five years. The results show that multiple models achieved state-of-the-art performance, producing high-fidelity, semantically aligned, and increasingly temporally coherent sound effects across tasks. However, despite these advances, the review identifies persistent challenges, including limitations in temporal synchronization for complex multi-event scenarios, gaps between objective metrics and human perception, and trade-offs between controllability and generative diversity. Overall, the chapter highlights that AI-driven sound effect generation is progressing toward more adaptive, scalable, and context-aware systems, offering significant implications for future sound design workflows and interactive media applications.

Sandy Abdo, Bill Kapralos, Priyamvada Tripathi +2

Ontario Tech University, Oshawa, ON, Canada · Durham College, Oshawa, ON, Canada · Carleton University, Ottawa, ON, Canada

Text-to-Audio Generation Sound Effects Generation Conditional Generative Modeling Audio Generation

Aug 3, 2026cs.CV

GSRAIN: Physically Calibrated High-/Low-Frequency Rainfall Synthesis for 3D Gaussian Driving Scenes

Existing rainfall simulation methods for autonomous driving remain limited in physical controllability and multi-view consistency. This paper presents GSRAIN, a high-/low-frequency rainfall synthesis method for 3D Gaussian Splatting (3DGS) driving scenes. GSRAIN constructs a high-frequency raindrop model from measured rainfall data and generates low-frequency rainy appearance using a geometry-aware single-step diffusion model. The two effects are then fused in a unified 3DGS scene, enabling rainfall-intensity control over the range of 0--13~mm/h. The proposed method achieves a Fréchet Inception Distance (FID) of 149.09, outperforming CycleGAN-Turbo (155.71) and WeatherEdit (157.94). Object-detection and closed-loop driving experiments further show that the generated scenes expose scene-dependent performance changes of the evaluated algorithms under controllable rainfall. These results indicate that GSRAIN provides an effective approach for constructing physically controllable, repeatable, and closed-loop-compatible rainy-weather test scenes for autonomous driving.

Fanyu Wang, Longgao Zhang, Junyi Chen

Fanyu Wang, Longgao Zhang, and Junyi Chen are with the College of Automotive and Energy Engineering, Tongji University, Shanghai, China.

3D Gaussian Splatting Conditional Generative Modeling Autonomous Driving Simulation Autonomous Driving Scenario Generation

Aug 3, 2026cs.CV

GeoCore-9B: Towards Geo-Aware Generative Foundation Models in Earth Observation

Existing generative models for earth observation (EO) predominantly rely on fine-tuning natural image priors, which limits their scalability and introduces perspective biases that conflict with geospatial constraints. To address this, we introduce GeoCore-9B, a 9-billion-parameter generative foundation model, which is the first of its scale to be trained from scratch exclusively on EO data. Unlike previous EO foundation models, GeoCore-9B is built upon a Flow Matching-based Diffusion Transformer (DiT) and natively conditions generation on text descriptions and continuous geospatial metadata, including ground sample distances, latitudes, and longitudes. To overcome the convergence and spatial disorientation challenges of training at this scale, we propose a Geospatial Semantic Alignment loss. This objective distills structural Earth surface priors (e.g., terrain and urban areas) from a frozen specialist teacher network, constraining the diffusion latent trajectory during training without adding inference overhead. Pre-trained on the global-scale Git-10M dataset, GeoCore-9B demonstrates strong downstream versatility. Beyond standard proxy generative tasks, we show that GeoCore-9B can be effectively adapted for practical EO applications, including highly challenging tasks such as cloud removal and SAR-to-optical cross-modal translation. Extensive evaluations confirm that GeoCore-9B establishes new state-of-the-art performance in both visual fidelity and geographic structural accuracy.

Jeonghyeok Do, Munchurl Kim

Information & Electronics Research Institute KAIST · School of Electrical Engineering KAIST

Geospatial Foundation Models Diffusion-Based Image Generation Conditional Generative Modeling