Class Imbalance

This paper introduces the use of per-class regularization hyperparameters in Gabriel graph-based binary classifiers. We demonstrate how the quality index used for regularization behaves both in the margin region and in the presence of outliers, and how incorporating this regularization flexibility can lead to solutions that effectively eliminate outliers while training the classifier. We also show how it can address class imbalance by generating higher and lower thresholds for the majority and minority classes, respectively. Thus, rather than having a single solution based on fixed thresholds, flexible thresholds expand the solution space and can be optimized through hyperparameter tuning algorithms. Friedman test shows that flexible thresholds are capable of improving Gabriel graph-based classifiers.

Machine learning-based intrusion detection requires complex models to capture patterns in high-dimensional, noisy, and class-imbalanced raw network traffic, yet deploying such models remains impractical on resource-constrained devices with limited processing power and memory. In this paper, we present a correlation-aware divide-and-conquer learning technique that decomposes a complex learning problem into smaller, more manageable subproblems. This enables lightweight models as simple as decision trees to be trained on focused subtasks, yielding up to 43.3% higher local accuracy and up to 257 times reduction in model size on real-world network intrusion detection datasets, while also improving adversarial robustness and explainability.

Active learning (AL) has emerged as a crucial strategy for reducing the prohibitive costs associated with medical image segmentation. However, standard uncertainty-based AL methods typically focus on maximizing performance metrics, ignoring performance disparities or fairness across groups with sensitive attributes. While fair active learning has been explored in classification tasks, its intersection with medical image segmentation remains unaddressed. In this work, we introduced a fairness-aware active learning framework with a Weighted Entropy selection strategy that modulates uncertainty based on current group-specific performance estimates on the labeled set. To decouple true epistemic uncertainty from anatomical volume variances, we further utilized a masked, scaled entropy restricted to the region of interest. The framework was evaluated on synthetic T1-weighted brain MRIs with controlled left caudate bias in both strong and weak bias settings. A 3D U-Net was trained to segment the left caudate under several AL strategies, starting from both demographically balanced and strongly imbalanced initial labeled sets. Experiments demonstrated that our method markedly reduces performance disparities between groups compared to random sampling and standard uncertainty sampling. By prioritizing poorly segmented subgroups during the AL cycles, our method consistently achieved the highest equity-scaled performance and reduced the disparity metric by 75% (strong bias) and 86% (weak bias) relative to standard entropy at the final budget. Overall, this work is among the first studies on fair AL for medical image segmentation, offering an efficient strategy to train more equitable models in resource-constrained environments.

This paper investigates sentiment classification of Steam game reviews using an attention-based Bidirectional Long Short-Term Memory (BiLSTM) model. Using a dataset of 50,000 reviews sampled from a larger Steam review corpus, the authors compare a traditional machine learning baseline based on TF-IDF and PyCaret AutoML with a deep learning approach implemented in PyTorch. The proposed BiLSTM+Attention model is trained with class-weighted cross-entropy to address class imbalance and achieves 83% accuracy and 85% weighted F1-score on the test set, with 90% recall for negative reviews. The paper also presents attention visualizations to show interpretability by highlighting sentiment-bearing words. The study concludes that the BiLSTM+Attention model is effective for analyzing user sentiment in Steam reviews and useful for helping developers understand player feedback.

Medical imaging datasets are often characterized by extreme class imbalances, where rare pathologies are significantly underrepresented compared to common conditions. This imbalance poses a dual challenge for Open-Set Recognition (OSR): models must maintain high classification accuracy on known classes while reliably rejecting unknown samples unseen during training in the clinical settings. While recently proposed Deep Simplex Classifier (DSC)\cite{cevikalp2024reaching} and UnCertainty-aware Deep Simplex Classifier (UCDSC)\cite{Aditya_2026_WACV} successfully leverage Neural Collapse to ensure maximal inter-class separation, they rely on a uniform margin that does not account for the varying densities of medical classes. In this paper, we propose DMDSC an enhanced framework featuring a dynamic margin approach. Our approach automatically adapts class-specific margins based on label frequency, enforcing a higher penalty and tighter feature clustering for rare pathologies to counteract the effects of data imbalance. Extensive experiments conducted on diverse medical benchmarks on BloodMNIST\cite{medmnistv2}, OCTMNIST\cite{medmnistv2}, DermaMNIST\cite{medmnistv2}, and BreaKHis~\cite{spanhol2015dataset} datasets, demonstrate that our framework outperforms state-of-the-art methods.

Dataset Distillation aims to compress a large dataset into a small synthetic one while maintaining predictive performance. We show that as different demographic groups exhibit distinct predictive patterns, the distillation process struggles to simultaneously preserve informative signals for all subgroups, regardless of whether group sizes are mildly or severely imbalanced. Consequently, models trained on distilled data can experience substantial performance drops for certain subgroups, leading to fairness gaps. Crucially, these gaps do not disappear by merely correcting group imbalance, since they stem from fundamental mismatches in subgroup predictive patterns rather than from sample-size disparities alone. We therefore formally analyze the interaction between these two sources of bias and cast the solution as identifying a group-imbalance-agnostic barycenter of the predictive information that induces similar representations across all subgroups. By distilling toward this shared aggregate representation, we show that group fairness concerns can be reduced. Our approach is compatible with existing distillation methods, and empirical results show that it substantially reduces bias introduced by dataset distillation. Code is available at https://github.com/mhmoslemi/COBRA.

Fine-tuning pretrained models has become a standard approach to adapting pretrained knowledge to improve the accuracy on new sparse, imbalance datasets. However, issues arise when optimization falls into a collapsed state, where the model gets stuck, leading to degraded performance and unstable training. One possible reason for this is the cancellation of gradients across training examples. To address this problem, we propose a novel algorithm, dynamic scaled gradient descent (\mName), that directly modifies the gradients returned by training examples, specifically, scaling down the gradients of correctly classified examples using a dynamic scaler. This strategy offers both theoretical and empirical advantages in improving training stability. Experiments on a variety of benchmark datasets, spanning multiple tasks and large pretrained models, demonstrate that our method consistently reduces performance variance and surpasses the accuracy of existing approaches.

Learning algorithms can be significantly improved by routing complex or uncertain inputs to specialized experts, balancing accuracy with computational cost. This approach, known as learning to defer, is essential in domains like natural language generation, medical diagnosis, and computer vision, where an effective deferral can reduce errors at low extra resource consumption. However, the two-stage learning to defer setting, which leverages existing predictors such as a collection of LLMs or other classifiers, often faces challenges due to an expert imbalance problem. This imbalance can lead to suboptimal performance, with deferral algorithms favoring the majority expert. We present a comprehensive study of two-stage learning to defer in expert imbalance settings. We cast the deferral loss optimization as a novel cost-sensitive learning problem over the input-expert domain. We derive new margin-based loss functions and guarantees tailored to this setting, and develop novel algorithms for cost-sensitive learning. Leveraging these results, we design principled deferral algorithms, MILD (Margin-based Imbalanced Learning to Defer), specifically suited for expert imbalance settings. Extensive experiments demonstrate the effectiveness of our approach, showing clear improvements over existing baselines on both image classification and real-world Large Language Model (LLM) routing tasks.

Exploiting deep learning in medical imaging faces critical challenges, including strict privacy constraints, heterogeneous imaging devices with varying acquisition properties, and class imbalance due to the uneven prevalence of pathologies. In this work, we propose FedSSG, a novel Federated Learning framework that addresses domain shifts caused by diverse imaging devices while mitigating the under-representation of rare pathologies. The key contribution is a strategy for generating synthetic samples and distributing them across clients to improve coverage of both underrepresented pathologies and imaging devices. Experimental results demonstrate that our approach significantly enhances model performance and generalization across heterogeneous institutions, with minimal computational overhead at the client side.

Public opinion towards the Free Nutritious Meal Program (MBG) on YouTube social media reflects diverse community responses. This study applies the Long Short-Term Memory (LSTM) method to classify sentiments from 7,733 YouTube comments. The results show that the LSTM model achieves 89% accuracy, with strong performance on negative sentiment (F1-score 0.94) but weaker performance on positive sentiment (F1-score 0.55) due to class imbalance, as negative data account for 87.7% of the dataset. These findings confirm the effectiveness of LSTM for sentiment analysis of Indonesian text while highlighting the challenge of imbalanced data. This research contributes to social media-based public policy evaluation

Class-level evaluation can conceal substantial performance disparities across subconcepts within the same class, causing models that perform well on average to fail on specific subpopulations. Prior work has shown that common evaluation measures for imbalanced classification are biased toward larger minority subconcepts and that utility-based reweighting using true subconcept labels can mitigate this bias; however, such labels are rarely available at test time. We introduce a practical utility-weighted evaluation that replaces unavailable subconcept labels with predicted posterior probabilities from a multiclass subconcept model. Evaluation weights are defined as the expected utility under this posterior, yielding a soft, uncertainty-aware metric we call predicted-weighted balanced accuracy (pBA). Experiments on tabular benchmarks as well as medical-imaging and text datasets show that unweighted scores can be misleading under within-class heterogeneity, while pBA provides more stable and interpretable assessments when subconcept distributions are uneven but not pathological. Our code is available at: https://anonymous.4open.science/r/correcting-bias-imbalance-9C6C/.

Imbalanced classification remains a pervasive challenge in machine learning, particularly when minority samples are too scarce to provide a robust discriminative boundary. In such extreme scenarios, conventional models often suffer from unstable decision boundaries and a lack of reliable error control. To bridge the gap between generative modeling and discriminative classification, we propose a two-stage framework \textbf{VAE-Inf} that integrates deep representation learning with statistically interpretable hypothesis testing. In the first stage, we adopt a one-class modeling perspective by training a variational autoencoder (VAE) exclusively on majority-class data to capture the underlying reference distribution. The resulting latent posteriors are aggregated via a Wasserstein barycenter to construct a global Gaussian reference model, providing a geometrically principled baseline for the majority class. In the second stage, we transform this generative foundation into a discriminative classifier by fine-tuning the encoder with limited minority samples. This is achieved through a novel distribution-aware loss that enforces probabilistic separation between classes based on variance-normalized projection statistics. For inference, we introduce a projection-based score that admits a natural hypothesis testing interpretation, allowing for a distribution-free calibration procedure. This approach yields exact finite-sample control of the Type-I error (false positive rate) without relying on restrictive parametric assumptions. Extensive experiments on diverse real-world benchmarks demonstrate that our framework achieves competitive performance against other approaches. The codes are available upon request.

Vision-Language Models (VLMs) are frequently undermined by object hallucination, generating content that contradicts visual reality, due to an over-reliance on linguistic priors. We introduce Positive-and-Negative Decoding (PND), a training-free inference framework that intervenes directly in the decoding process to enforce visual fidelity. PND is motivated by our finding of an attention imbalance in VLMs, where visual features are under-weighted. Our framework introduces a dual-path contrast: a positive path that amplifies visual evidence and a negative path that constructs counterfactuals to penalize prior-dominant generation. By contrasting outputs from both paths during decoding, PND steers generation toward visually grounded results. Experiments on POPE, MME, and CHAIR demonstrate state-of-the-art performance without retraining.

In this paper, a deep learning framework is proposed for automatic facial emotion based on deep convolutional networks. In order to increase the generalization ability and the robustness of the method, the dataset size is increased by merging three publicly available facial emotion datasets: CK+, FER+ and KDEF. Despite the increase in dataset size, the minority classes still suffer from insufficient number of training samples, leading to data imbalance. The data imbalance problem is minimized by online and offline augmentation techniques and random weighted sampling. Experimental results demonstrate that the proposed method can recognize the seven basic emotions with 82% accuracy. The results demonstrate the effectiveness of the proposed approach in tackling the challenges of data imbalance and improving classification performance in facial emotion recognition.

A common strategy in transfer learning is few shot fine-tuning, but its success is highly dependent on the quality of samples selected as training examples. Active learning methods such as uncertainty sampling and diversity sampling can select useful samples. However, under extremely low-resource and class-imbalanced conditions, they often favor outliers rather than truly informative samples, resulting in degraded performance. In this paper, we introduce RADS (Reinforcement Adaptive Domain Sampling), a robust sample selection strategy using reinforcement learning (RL) to identify the most informative samples. Experimental evaluations on several real world clinical datasets show our sample selection strategy enhances model transferability while maintaining robust performance under extreme class imbalance compared to traditional methods.

Class imbalance is a widespread challenge in NLP tasks, significantly hindering robust performance across diverse domains and applications. We introduce Hardness-Aware Meta-Resample (HAMR), a unified framework that adaptively addresses both class imbalance and data difficulty. HAMR employs bi-level optimizations to dynamically estimate instance-level weights that prioritize genuinely challenging samples and minority classes, while a neighborhood-aware resampling mechanism amplifies training focus on hard examples and their semantically similar neighbors. We validate HAMR on six imbalanced datasets covering multiple tasks and spanning biomedical, disaster response, and sentiment domains. Experimental results show that HAMR achieves substantial improvements for minority classes and consistently outperforms strong baselines. Extensive ablation studies demonstrate that our proposed modules synergistically contribute to performance gains and highlight HAMR as a flexible and generalizable approach for class imbalance adaptation. Code is available at https://github.com/trust-nlp/ImbalanceLearning.

Diffusion policies are becoming mainstream in robotic manipulation but suffer from hard negative class imbalance due to uniform sampling and lack of sample difficulty awareness, leading to slow training convergence and frequent inference timeout failures. We propose VADF (Vision-Adaptive Diffusion Policy Framework), a vision-driven dual-adaptive framework that significantly reduces convergence steps and achieves early success in inference, with model-agnostic design enabling seamless integration into any diffusion policy architecture. During training, we introduce Adaptive Loss Network (ALN), a lightweight MLP-based loss predictor that quantifies per-step sample difficulty in real time. Guided by hard negative mining, it performs weighted sampling to prioritize high-loss regions, enabling adaptive weight updates and faster convergence. In inference, we design the Hierarchical Vision Task Segmenter (HVTS), which decomposes high-level task instructions into multi-stage low-level sub-instructions based on visual input. It adaptively segments action sequences into simple and complex subtasks by assigning shorter noise schedules with longer direct execution sequences to simple actions, and longer noise steps with shorter execution sequences to complex ones, thereby dramatically reducing computational overhead and significantly improving the early success rate.

Parameter-efficient continual learning aims to adapt pre-trained models to sequential tasks without forgetting previously acquired knowledge. Most existing approaches treat continual learning as avoiding interference with past updates, rather than considering what properties make the current task-specific update naturally preserve previously acquired knowledge. From a knowledge-decomposition perspective, we observe that low-rank adaptations exhibit highly imbalanced singular value spectra: a few dominant components absorb most of the adaptation energy, thereby (i) more likely to disrupt previously acquired knowledge and (ii) making the update more vulnerable to interference from subsequent tasks. To enable explicit balance among components, we decouple the magnitude of the task update from its directional structure and formulate it as a constrained optimization problem on a restricted Stiefel manifold. We address this problem using a projected first-order method compatible with standard deep-learning optimizers used in vision-language models. Our method mitigates both backward and forward forgetting, consistently outperforming continual learning baselines. The implementation code is available at https://github.com/haodotgu/EBLoRA.

Rare-event prediction is critical in domains such as healthcare, finance, reliability engineering, customer support, aviation safety, where positive outcomes are infrequent yet potentially catastrophic. Extreme class imbalance biases conventional models toward majority-class predictions, limiting recall, calibration, and operational usefulness. We propose LPCORP (Low-Prevalence CORrector for Prediction)*, a two-stage framework that combines reasoning-enhanced prediction with confidence-based outcome correction. A reasoning model first produces enriched predictions from narrative inputs, after which a lightweight classifier evaluates and selectively corrects these outputs to mitigate prevalence-driven bias. In this study we used Logistic-Regression (LR) and a simple Multilayer Perceptron (MLP) classifiers for this purpose. We evaluate LPCORP on real-world datasets from medical and consumer service domains. The results show that this method transforms the original rare-event prediction problem into a more balanced supervised correction task without discarding or resampling observations. Test-set evaluation demonstrates substantially improved performance, particularly in precision, which is a known weakness in low-prevalence data. We further provide a cost-reduction analysis comparing the expenses associated with rare-event damage control without preventive measures to those incurred when low-cost, prediction-based preventive interventions are applied that showed up to 40+% reduction in some cases.

Numerous studies on Boosting attempt to mitigate classification bias caused by class imbalance. However, existing studies have yet to explore the collaborative optimization of imbalanced learning and model training. This constraint hinders further performance improvements. To bridge this gap, this study proposes a collaborative optimization Boosting model of multiclass imbalanced learning. By integrating the density factor and the confidence factor, this model implements a noise-resistant weight update mechanism alongside a dynamic sampling strategy. Rather than functioning as independent components, these modules are tightly integrated to orchestrate weight updates, sample region partitioning, and region-guided sampling. Thus, this study proposes the collaborative optimization of imbalanced learning and model training. Extensive experiments on 40 public imbalanced datasets demonstrate that the proposed model significantly outperforms seven state-of-the-art baselines. The code and datasets for this paper are available at: https://github.com/ChuantaoLi/DARG.

Medical decision systems increasingly rely on data from multiple sources to ensure reliable and unbiased diagnosis. However, existing multimodal learning models fail to achieve this goal because they often overlook two critical challenges. First, various data modalities may learn unevenly, thereby converging to a model biased towards certain modalities. Second, the model may emphasize learning on certain demographic groups causing unfair performances. The two aspects can influence each other, as different data modalities may favor respective groups during optimization, leading to both imbalanced and unfair multimodal learning. This paper proposes a novel approach called MultiFair for multimodal medical classification, which addresses these challenges with a dual-level gradient modulation process. MultiFair dynamically modulates training gradients regarding the optimization direction and magnitude at both data modality and group levels. We evaluate MultiFair on three real-world medical classification datasets with diverse demographic attributes,including multiclass classification and missing-modality settings. Experimental results demonstrate its effectiveness.

The class imbalance problem refers to the disproportionate distribution of samples across different classes within a dataset, where the minority classes are significantly underrepresented. This issue is also prevalent in graph-structured data. Most graph neural networks (GNNs) implicitly assume a balanced class distribution and therefore often fail to account for the challenges introduced by class imbalance, which can lead to biased learning and degraded performance on minority classes. We identify a quality inconsistency problem in synthesized nodes, which leads to suboptimal performance under graph imbalance conditions. To mitigate this issue, we propose GraphIFE (Graph Invariant Feature Extraction), a novel framework designed to mitigate quality inconsistency in synthesized nodes. Our approach incorporates two key concepts from graph invariant learning and introduces strategies to strengthen the embedding space representation, thereby enhancing the model's ability to identify invariant features. Extensive experiments demonstrate the framework's efficiency and robust generalization, as GraphIFE consistently outperforms various baselines across multiple datasets. The code is publicly available at https://github.com/flzeng1/GraphIFE.

The tabular form constitutes the standard way of representing data in relational database systems and spreadsheets. But, similarly to other forms, tabular data suffers from class imbalance, a problem that causes serious performance degradation in a wide variety of machine learning tasks. One of the most effective solutions dictates the usage of Generative Adversarial Networks (GANs) in order to synthesize artificial data instances for the under-represented classes. Despite their good performance, most of the proposed GAN models do not take into account the vector subspaces of the input samples in the real data space, leading to data generation in arbitrary locations. In addition, the class labels are handled in the same manner as the other categorical variables, so conditional sampling by class is rendered less effective. To overcome these problems, this study presents ctdGAN, a conditional GAN for alleviating class imbalance in tabular datasets. Initially, ctdGAN executes a space partitioning step to assign cluster labels to the input samples. Subsequently, it utilizes these labels to synthesize samples via a novel probabilistic sampling strategy and a new loss function that penalizes both cluster and class mis-predictions. In this way, ctdGAN generates samples in subspaces that resemble those of the original data distribution. We also introduce several other improvements, including a simple, yet effective cluster-wise scaling technique that captures multiple feature modes without affecting data dimensionality. The evaluation of ctdGAN with 14 imbalanced datasets demonstrated its strong ability in generating high fidelity samples and improving classification accuracy.

Detecting fraudulent credit card transactions remains a significant challenge, due to the extreme class imbalance in real-world data and the often subtle patterns that separate fraud from legitimate activity. Existing research commonly attempts to address this by generating synthetic samples for the minority class using approaches such as GANs, VAEs (Variational Autoencoders), or hybrid generative models. However, these techniques, particularly when applied only to minority-class data, tend to result in overconfident classifiers and poor latent cluster separation, ultimately limiting real-world detection performance. In this study, we propose the Causal Prototype Attention Classifier (CPAC), an interpretable architecture that promotes class-aware clustering and improved latent space structure through prototype-based attention mechanisms and we couple it with the encoder of a Variational Autoencoder-Generative Adversarial Network (VAE-GAN) in order to achieve improved latent cluster separation moving beyond post-hoc sample augmentation. We compared CPAC-augmented models to traditional oversamplers, such as SMOTE, as well as to state-of-the-art generative models, both with and without CPAC-based latent classifiers. Our results show that classifier-guided latent shaping with CPAC delivers superior performance, achieving an F1-score of 93.74% and recall of 92.85%, along with improved latent cluster separation. Further ablation studies and visualizations provide deeper insight into the benefits and limitations of classifier-driven representation learning for fraud detection. The codebase for this work can be found at the following link: https://github.com/claudiunderthehood/VAEGAN-CPAC.git.

Data imbalance persists as a pervasive challenge in regression tasks, introducing bias in model performance and undermining predictive reliability. This is particularly detrimental in applications aimed at predicting rare events that fall outside of the domain of the bulk of the training data. In this study, we review the current state-of-the-art regarding sampling-based methods and cost-sensitive learning. Additionally, we propose novel approaches to mitigate model bias. To better assess the importance of data, we introduce the density-distance and density-ratio relevance functions, which effectively integrate empirical frequency of data with domain-specific preferences, offering enhanced interpretability for end-users. Furthermore, we present advanced mitigation techniques (cSMOGN and crbSMOGN), which build upon and improve existing sampling methods. In a quantitative evaluation, we benchmark state-of-the-art methods on 10 synthetic and 42 real-world datasets, using neural networks, XGBoosting trees and Random Forest models. Our analysis shows that while most strategies improve performance on rare samples, they degrade it on frequent ones. The trade-off becomes larger the more the performance on rare samples is increased. However, to reduce this effect we demonstrate that constructing an ensemble of models -- one trained with imbalance mitigation and another without -- can be used. The key findings underscore the superior performance of our novel crbSMOGN sampling technique with the density-ratio relevance function for neural networks, outperforming state-of-the-art methods.

Class imbalance poses a significant challenge in classification tasks, often causing standard learning algorithms to become biased toward the majority class. Cost-sensitive learning (CSL) addresses this issue by assigning higher penalties to minority-class misclassifications. However, conventional CSL typically applies a uniform penalty to all minority-class instances, ignoring the fact that minority samples may differ substantially in terms of local safety, overlap, boundary ambiguity, and outlier-like behavior. Uniform penalization can therefore introduce undue bias, increasing the number of misclassifications. In this study, we propose iCost, an instance-complexity-aware CSL framework that assigns adaptive penalties to minority-class samples according to their estimated learning difficulty. This fine-grained penalization strategy ensures fairer weighting, reduces unwarranted bias, and improves overall classification performance. Two complementary complexity estimation strategies are introduced: Neighbor-iCost, based on local neighborhood composition, and Gini-iCost, based on Gini-impurity-based feature-space partitioning. Extensive experiments on 65 binary and 10 multiclass imbalanced datasets show that iCost outperforms conventional CSL by a clear margin and remains highly competitive with widely used resampling methods. To support reproducibility and practical adoption, the proposed algorithm has been released as a scikit-learn-compatible Python package through PyPI. This work offers a fresh perspective on imbalanced learning by integrating instance-level data complexity into the learning process, opening new avenues for developing adaptive, complexity-aware strategies for imbalanced classification.

Deploying deep learning-based imaging tools across various clinical sites poses significant challenges due to inherent domain shifts and regulatory hurdles associated with site-specific fine-tuning. For histopathology, stain normalization techniques can mitigate discrepancies, but they often fall short of eliminating inter-site variations. Therefore, we present Data Alchemy, an explainable stain normalization method combined with test time data calibration via a template learning framework to overcome barriers in cross-site analysis. Data Alchemy handles shifts inherent to multi-site data and minimizes them without needing to change the weights of the normalization or classifier networks. Our approach extends to unseen sites in various clinical settings where data domain discrepancies are unknown. Extensive experiments highlight the efficacy of our framework in tumor classification in hematoxylin and eosin-stained patches. Our explainable normalization method boosts classification tasks' area under the precision-recall curve(AUPR) by 0.165, 0.545 to 0.710. Additionally, Data Alchemy further reduces the multisite classification domain gap, by improving the 0.710 AUPR an additional 0.142, elevating classification performance further to 0.852, from 0.545. Our Data Alchemy framework can popularize precision medicine with minimal operational overhead by allowing for the seamless integration of pre-trained deep learning-based clinical tools across multiple sites.

Class imbalance complicates probabilistic classification because standard training objectives emphasize majority-class performance. Synthetic oversampling can reduce imbalance, but discrepancies between the synthetic and target minority distributions may bias the fitted classifier, especially because synthetic samples depend on the observed data. We propose a bias-correction procedure that estimates the generator-induced loss discrepancy from a held-out subset of majority observations and transfers this correction to the minority class under a uniform bias-transfer condition. We establish finite-sample bounds for bias transfer and for the excess balanced risk of the resulting empirical risk minimizer, and characterize a regime in which SMOTE induces non-negligible loss bias. The framework can also be implemented in imbalanced multi-task learning and propensity-score estimation, with details provided in the Supplementary Material. Real data analyses show that the correction is most useful when synthetic distortion is appreciable.