Overview

Clinical decision support studies how computer systems can help clinicians interpret patient records, identify risks, choose tests, and plan treatment. Approaches range from statistical and causal models to Bayesian reasoning, reinforcement learning, guideline rules and knowledge graphs, and language-model systems using retrieval or multiple agents; hybrid designs often use AI to extract information and deterministic logic to apply clinical rules. Systems are tested on electronic health records, guideline-based cases, medical images, and medication tasks, with growing use of reader studies and prospective workflow evaluations. A central challenge is that strong benchmark accuracy does not ensure safe performance with incomplete or shifting data, and systems must manage uncertainty, harmful errors, clinician oversight, and fit with real workflows.

Latest papers

CardsList

244 papers27 papers in the last four weeks, up 42% on the four weeks before. 0.2% of all new papers.

  1. Conditional anomaly detection using soft harmonic functions: An application to clinical alerting

    Apr 23, 2026Michal Valko, Hamed Valizadegan, Branislav Kveton +2HealthcareClinical Decision Support

  2. Trustworthy Clinical Decision Support Using Meta-Predicates and Domain-Specific Languages

    Apr 23, 2026Michael Bouzinier, Sergey Trifonov, Michael Chumack +2HealthcareClinical Decision Support

  3. MoBayes: A Modular Bayesian Framework for Separating Reasoning from Language in Conversational Clinical Decision Support

    Apr 21, 2026Yusuf Kesmen, Fay Elhassan, Jiayi Ma +7Selective PredictionClinical Decision Support

  4. Toward Zero-Egress Psychiatric AI: On-Device LLM Deployment for Privacy-Preserving Mental Health Decision Support

    Apr 20, 2026Eranga Bandara, Asanga Gunaratna, Ross Gore +9On-Device Language Model InferencePrivacy-Preserving Language Models

  5. Neuro-Symbolic Resolution of Recommendation Conflicts in Multimorbidity Clinical Guidelines

    Apr 19, 2026Shiyao Xie, Jian DuClinical Decision SupportNeuro-Symbolic Reasoning

  6. DeepER-Med: Advancing Deep Evidence-Based Research in Medicine Through Agentic AI

    Apr 16, 2026Zhizheng Wang, Chih-Hsuan Wei, Joey Chan +19Deep Research AgentsHealthcare

  7. Blinded Multi-Rater Comparative Evaluation of a Large Language Model and Clinician-Authored Responses in CGM-Informed Diabetes Counseling

    Apr 16, 2026Zhijun Guo, Alvina Lai, Emmanouil Korakas +6Clinical Decision SupportRAG Evaluation

  8. From Prediction to Intervention: The Evolution of AI in Biomedicine

    Apr 14, 2026Andrew Feinberg, Aleksandr Sarachakov, Viktor Svekolkin +3Clinical Decision-MakingClinical Decision Support

  9. Development, Evaluation, and Deployment of a Multi-Agent System for Thoracic Tumor Board

    Apr 14, 2026Tim Ellis-Caleo, Timothy Keyes, Nerissa Ambers +5Text SummarizationSummarization Evaluation

  10. From Answers to Arguments: Toward Trustworthy Clinical Diagnostic Reasoning with Toulmin-Guided Curriculum Goal-Conditioned Learning

    Apr 13, 2026Chen Zhan, Xiaoyu Tan, Gengchen Ma +3Clinical ReasoningLLM Reliability

  11. ClinicBot: A Guideline-Grounded Clinical Chatbot with Prioritized Evidence RAG and Verifiable Citations

    Apr 11, 2026Navapat Nananukul, Mayank KejriwalClinical QAEvidence-Grounded Generation

  12. From Synthesis to Clinical Assistance: A Strategy-Aware Agent Framework for Autism Intervention based on Real Clinical Dataset

    Apr 9, 2026Junhong Lai, Shuzhong Lai, Yanhao Yu +5Autism Spectrum DisorderClinical Decision Support

  13. SymptomWise: A Deterministic Reasoning Layer for Reliable and Efficient AI Systems

    Apr 7, 2026Isaac Henry, Avery Byrne, Christopher Giza +2Clinical Decision SupportClinical Reasoning

  14. Guideline2Graph: Profile-Aware Multimodal Parsing for Executable Clinical Decision Graphs

    Apr 2, 2026Onur Selim Kilic, Yeti Z. Gurbuz, Cem O. Yaldiz +4Clinical Decision SupportClinical Information Extraction

  15. Ontology-Aware Design Patterns for Clinical AI Systems: Translating Reification Theory into Software Architecture

    Apr 2, 2026Florian Odi StummerSoftware EngineeringClinical Decision Support

  16. When AI Gets it Wrong: Reliability and Risk in AI-Assisted Medication Decision Systems

    Apr 1, 2026Khalid Adnan AlsayedClinical Decision SupportAI Risk Management

  17. Toward Vibe Medicine: A Self-Evolving Multi-Agent Framework for Clinical Decision Support

    Apr 1, 2026Qianxue Zhang, Yiming Ren, Shihuan Qin +18Clinical Decision SupportMulti-Agent LLM Systems

  18. Learning Diagnostic Reasoning for Decision Support in Toxicology

    Mar 31, 2026Nico Oberländer, David Bani-Harouni, Tobias Zellner +3Clinical Decision SupportRL for Language Model Reasoning

  19. Improving Clinical Diagnosis with Counterfactual Multi-Agent Reasoning

    Mar 29, 2026Zhiwen You, Xi Chen, Aniket Vashishtha +5Medical DiagnosisClinical Decision Support

  20. Clinical Reasoning AI for Oncology Treatment Planning: A Multi-Specialty Case-Based Evaluation

    Mar 27, 2026Philippe E. Spiess, Md Muntasir Zitu, Alison Walker +33Clinical Decision SupportOncology

  21. AD-CARE: A Guideline-grounded, Modality-agnostic LLM Agent for Real-world Alzheimer's Disease Diagnosis with Multi-cohort Assessment, Fairness Analysis, and Reader Study

    Mar 26, 2026Wenlong Hou, Sheng Bi, Guangqian Yang +16Alzheimer's Disease ClassificationClinical Decision Support

  22. Integrating Causal Machine Learning into Clinical Decision Support Systems: Insights from Literature and Practice

    Mar 25, 2026Domenique Zipperling, Lukas Schmidt, Benedikt Hahn +2Clinical Decision SupportClinical Decision-Making

  23. Dialogue to Question Generation for Evidence-based Medical Guideline Agent Development

    Mar 25, 2026Zongliang Ji, Ziyang Zhang, Xincheng Tan +5Clinical Decision SupportEvidence-Grounded Generation

  24. Guideline-grounded retrieval-augmented generation for ophthalmic clinical decision support

    Mar 23, 2026Shuying Chen, Sen Cui, Zhong CaoMultimodal RAGRetrieval-Augmented Generation

  25. HypeMed: Enhancing Medication Recommendations with Hypergraph-Based Patient Relationships

    Mar 19, 2026Xiangxu Zhang, Xiao Zhou, Hongteng Xu +1Medication RecommendationRecommender Systems

  26. PACE-RAG: Patient-Aware Contextual and Evidence-Constrained RAG for Clinical Drug Recommendation

    Mar 18, 2026Chaeyoung Huh, Hyunmin Hwang, Jung Hwan Shin +3Retrieval-Augmented GenerationClinical Decision Support

  27. Deployment and Evaluation of an EHR-integrated, Large Language Model-Powered Tool to Triage Surgical Patients

    Mar 18, 2026Jane Wang, Timothy Keyes, April S Liang +10Clinical TriageClinical Decision Support

  28. A Hybrid AI and Rule-Based Decision Support System for Disease Diagnosis and Management Using Labs

    Mar 16, 2026Muhammad Hammad Maqsood, Mubashir Sajid, Khubaib Ahmed +2Clinical Decision SupportMedical Diagnosis