Diffusion Models

In this paper, we are the first to examine the correlations between class frequency and the multi-scale noise schedule within diffusion models. For score-based generative models, low-density regions often lead to inaccurately estimated scores, thereby compromising the generation quality. Although the multi-scale noise schedule can alleviate this issue during the diffusion process, low-frequency classes still face the challenge of large low-density regions, resulting in more inaccurate estimated scores than high-frequency classes. Furthermore, high-frequency classes tend to dominate the score space, causing a convergence of most data points towards generating samples from these classes. Consequently, samples generated within low-frequency classes exhibit suboptimal quality and limited diversity. To address this challenge, we propose the Class-frequency Guided (CFRG) noise schedule, leveraging the insight that low-frequency classes should be endowed with larger-scale noises. To illustrate the effectiveness of our method, we conduct experiments on various tasks, including image generation, image classification, and text-to-image generation, using imbalanced datasets, i.e., CIFAR-100-LT, and ImageNet-LT. By employing the CFRG noise schedule, we achieve substantial improvements over baselines, manifesting the crucial role of frequency statistics in noise schedule design.

We present GeoFace, a geometry-constrained multi-view diffusion framework for consistent face generation from a single input. % While recent multi-view diffusion models achieve photorealistic synthesis at the per-view level, they lack an explicit mechanism to enforce a shared 3D structure across views, often leading to inconsistent geometry across viewpoints. To address this, GeoFace proposes a unified dual-stream framework for joint generation of multi-view RGB images and 3D face geometry, where the appearance and geometry streams interact through shared attention layers. To encourage the two streams to mutually constrain each other, we introduce a geometry-guided attention alignment loss that supervises the cross-attention between appearance and geometry tokens with 3D-consistent correspondences, enabling the appearance stream to correctly reference pose-invariant geometric cues for robust alignment across viewpoints. Geometry is represented as a canonical UV position map, derived from a FLAME mesh fitted to multi-view observations, serving as a view-invariant shared constraint across all generated views. Experiments on RenderMe-360 and NeRSemble demonstrate that GeoFace consistently outperforms existing methods in both visual quality and cross-view geometric consistency, facilitating more efficient 3D reconstruction.

Generative models have achieved remarkable success in data synthesis, though recent advances driven by increasing model scale have introduced challenges in computational cost and efficiency. Quantum machine learning offers a promising alternative, representing complex data distributions using compact, highly expressive models. Here, we propose QDiffusion-TS, the first quantum generative diffusion model for time series synthesis, and validate it on the IQM quantum processor. The framework extends a classical diffusion architecture by replacing feed-forward components within the denoising transformer with quantum neural networks, yielding a hybrid quantum transformer that reduces the number of trainable parameters in each replaced component by nearly three orders of magnitude. Evaluated on financial time series from Apple and Amazon, the model generates synthetic data that more accurately reproduces the real distributions, reducing Wasserstein distance by approximately 44% relative to its classical counterpart across both datasets. In a downstream forecasting task, augmentation with the generated data improves predictive performance by up to 71% in RMSE over a baseline trained solely on real data. These results show that quantum enhanced architectures can consistently match and frequently surpass classical performance with substantially fewer parameters, establishing a practical framework towards more efficient and scalable data-driven generative modelling.

We present PhysiFormer, a diffusion transformer for physically-plausible 3D object motion. Unlike video world models that operate in view-dependent pixel space, PhysiFormer represents objects as 3D meshes expressed in world coordinates. Given the initial vertex positions and velocities, as well as object material type, rigid or elastic, the model samples future vertex trajectories. While related neural physics approaches build on ad-hoc latent spaces or explicitly enforce rigidity and causality, PhysiFormer shows that excellent results can be obtained without any such inductive biases, by casting vertex trajectory prediction as a single denoising diffusion process directly in world coordinates. The probabilistic formulation captures uncertainty in the learned dynamics, enabling diverse plausible futures from initial conditions, making this framework potentially useful for applications with unobserved uncertainty. The model features attention factorised over time, space, and objects for efficiency, enabling permutation-invariant multi-object reasoning without needing explicit object encoding. Trained on over 100k simulated trajectories, PhysiFormer generates rigid and elastic mechanics, and generalises to mixed-material settings, unseen real-world geometries, and larger object counts. It substantially outperforms autoregressive baselines in trajectory accuracy, rigidity preservation, and momentum-based physical consistency. Our results position coordinate-space diffusion as a promising step toward view-invariant, geometry-aware world modelling for robotics, graphics, and physical design. Visualisations, code, and models are available at https://yimingc9.github.io/physiformer.

Earth Observation (EO) forecasting aims to predict future Earth surface dynamics from satellite observations under changing meteorological conditions. In this paper, we view this task as a partially observed, weather-driven world modeling problem, in which weather acts as a conditioning signal, while forecasting remains uncertain due to sparse observations and unobserved land-surface states. However, existing methods do not fully capture this setting: deterministic models collapse uncertainty into a single future prediction, while diffusion-based methods typically treat weather variables as undifferentiated conditioning signals, and existing benchmarks focus mainly on reconstruction accuracy rather than whether forecasts respond correctly to changed weather forcing.We introduce EO-WM, a video diffusion transformer for multispectral EO forecasting. EO-WM incorporates a physically informed conditioning framework that represents meteorological forcing through a climatological baseline, weather anomalies, and cumulative physical stress signals. Specifically, it separates baseline and anomaly through distinct conditioning pathways, and accumulates anomalous forcing over time to capture sustained heat and drought stress. To evaluate weather-response behavior beyond standard metrics, we introduce two diagnostic benchmarks: an Extreme Summer Benchmark for severity-aware prediction of vegetation degradation under extreme weather, and a Seasonal Matched-Pair Benchmark for testing response fidelity under changed weather forcing. Experiments show that EO-WM reduces the error in predicted Normalized Difference Vegetation Index (NDVI) decline amplitude by a relative 5.63% and improves directional hit rate by a relative 7.80%, while remaining competitive on standard pixel-level metrics. The benchmarks and model will be made open-source at https://github.com/Luo-Z13/EO-WM.

Video Diffusion Models (VDMs) is constrained by immense computational costs. While offline calibration-based acceleration suffers from calibration data dependency, prohibitive calibration duration, and susceptibility to distribution shifts, offline calibration-free methods eliminate these hurdles. However, since they rely on instantaneous zero-order approximations where the mapping between input and output differences varies in real-time, they are susceptible to observational noise and ignore the intrinsic momentum within the diffusion trajectory. In this paper, we propose NaviCache, a plug-and-play test-time self-calibration method re-conceptualizing feature evolution as an Inertial Navigation System (INS) problem. NaviCache bridges the fundamental domain gap and the non-stationary nature of diffusion by modeling the relative coupling between input and output variations. We introduce a dual-state estimation architecture that adaptively tracks the feature change ratio and its latent drift, initialized via a specialized Initial Alignment phase. By integrating a time-dependent noise schedule with an uncertainty-aware Measurement Update mechanism, NaviCache provides a theoretically grounded mechanism for error-bounded computation skipping. Extensive experiments on the HunyuanVideo, Wan, and Open-Sora series demonstrate that NaviCache exhibits more accurate error judgment for computation skipping and achieves outstanding comprehensive performance.

Developing robust artificial intelligence models for 4D (3D + time) medical imaging is constrained by limited annotated data, inter-device domain shifts, and privacy restrictions. To address this, we propose a 4D controllable generative framework for anatomically consistent data augmentation. A semi-supervised variational autoencoder learns a compact latent representation of anatomical volumes while jointly predicting aligned segmentation masks in a unified framework. Anatomical structure is then disentangled from temporal dynamics through a cascaded latent diffusion model (LDM). A static LDM generates subject-specific anatomy conditioned on clinical priors (diagnosis and volumes measures) and a subsequent motion LDM estimates residual latent motions, ensuring strict temporal coherence across the 4D sequence. The proposed approach was evaluated on cine cardiac MRI as a representative 4D imaging application. Experiments across multiple datasets demonstrate high controllability of static anatomy (Pearson r > 0.8) and strong temporal coherence (FVD = 288.08). In cross-vendor generalization experiments, augmenting training sets with synthetic 4D sequences significantly improves downstream segmentation performance. Using nnU-Net, the proposed augmentation strategy improves the average Dice score by 1.4% and reduces the Hausdorff Distance by 3.0mm compared to training on real data alone, for the left ventricle, Dice improves by 2.8% with a 5.4mm reduction in boundary error. Overall, this framework provides a scalable and controllable solution for 4D medical image synthesis, supporting the development of more robust models with limited annotations and cross-vendor variability. Code available on https://github.com/cyiheng/4DCardiacMRISynthesis.

Recent studies suggest that diffusion models can recover geometric structure in the data they are trained on, yet the supporting evidence has so far come mostly from natural-image data, where the underlying geometry itself is unknown. We study this question in a setting where the geometry is analytically tractable: constrained inverse kinematics (IK). Each task-space constraint defines a configuration-space manifold with known intrinsic dimension, giving direct ground truth for evaluating the geometry learned by the model. For each of the 6-DoF UR5 and 7-DoF Franka, we train a single conditional diffusion model across seven constraint families, spanning solution manifolds from discrete IK branches to self-motion manifolds. Our empirical results reveal that the intrinsic dimension recovered from the model's score function matches the analytical degrees of freedom of the corresponding constraint manifold across both robots. Moreover, linear interpolation in the latent space leads to generated solutions that remain close to the appropriate constraint manifold, indicating that the learned representation further captures geometric structure of the constraint family beyond intrinsic dimension alone. Constrained IK therefore offers a controlled setting for studying the intrinsic geometry learned by diffusion models.

Diffusion models have shown promise in drag-style editing. Previous works mainly focus on point-based drag, which is inherently ambiguous. This paper focuses on region-based drag and introduces a novel In-Context Region-based Drag (ICRDrag) method. Under the in-context learning framework, ICRDrag consumes a source image, a source region mask, and a target region mask, producing the target dragged image. Built upon the basic in-context learning model, we introduce two novel attention regularization: 1) image-mask attention consistency to ensure that a target region attends to similar source regions for image and mask modalities; 2) source-target attention correspondence to ensure the mutual correspondence between source and target regions. To facilitate region-based drag, we also construct Paired Region Dataset (PRD), a large-scale dataset with paired masks and images. Extensive experiments show that ICRDrag significantly outperforms existing methods in both quantitative metrics and user studies, achieving superior editing accuracy and visual fidelity. The dataset, code, and model are available at https://github.com/bcmi/ICRDrag-Region-Drag-Editing.

3D anomaly detection in point clouds is critical for high-precision industrial manufacturing. Reconstruction-based methods have laid a strong foundation by detecting 3D anomalies through comparisons between defective inputs and their reconstructed normal counterparts. However, existing methods still suffer from two challenges: 1) the foreground weak defective regions such as scratches are hard to reconstruct and detect, where the anomaly deviations in normalized point clouds can be as small as $10^{-3}$; 2) the background non-defective regions are prone to get positional bias in reconstruction, which leads to false positives. To address these challenges, we propose PCDiff, a point cloud diffusion framework for instance-level 3D anomaly generation and detection. In the generation phase, an instance-level multi-modal attention is embedded into the generation framework, where anomalies are conditioned with texture gradient, image patch, text and mask. The instance-level condition enables the high-quality generation of weak-defective anomalies. In the detection phase, a joint local-global reconstruction algorithm is introduced to ensure local anomaly restoration and global geometric consistency, which preserves background normal structure while restoring the foreground defect. Extensive experiments demonstrate that the proposed PCDiff significantly outperforms state-of-the-art methods in both 3D anomaly generation fidelity and reconstruction quality, leading to substantial improvements in anomaly detection accuracy.

Diffusion models have shown strong potential for multi-modal planning in end-to-end autonomous driving. However, most existing methods confine diffusion to the planning module, conditioning on fixed outputs from separate discriminative perception networks. This decoupled design propagates perception errors to the planner, increasing optimization difficulty and reducing robustness. To overcome these limitations, we propose UniTeD, a Unified Temporal Diffusion framework that jointly models perception and planning through iterative denoising in a shared generative space. By enabling bidirectional information exchange, the framework facilitates mutual refinement between tasks and improves robustness via noise-conditioned multi-task training. We further extend this unified diffusion paradigm to a streaming setting by incorporating temporal context. A Temporal Transition Module (TTM) is introduced to resolve the noise-level mismatch between historical and current frames. In addition, we propose an Anchor Refresh Strategy (ARS) to alleviate the training-inference distribution shift commonly observed in sparse diffusion-based end-to-end driving frameworks. Without bells and whistles, UniTeD achieves state-of-the-art performance across multiple benchmarks, surpassing both recent discriminative end-to-end methods and diffusion-based planning approaches.

AI-driven image-to-image synthesis is rapidly advancing, with growing applications in medical imaging. Multi-modal image analysis plays a crucial role in optimizing examination quality, yet acquiring multiple imaging modalities in clinical settings remains resource-intensive and time-consuming, especially for 3D imaging. To address this challenge, we propose a novel image-to-image translation model based on Brownian Bridge Diffusion Models (BBDM), which synthesizes magnetic resonance imaging (MRI) sequences from 2D axial slices. Our approach integrates a variational encoder-guided diffusion mechanism, leveraging probabilistic image distributions to enhance synthesis quality. Evaluated on the BraTS 2021 dataset, our Probabilistic-BBDM (Prob-BBDM) achieves superior performance across multiple translation tasks, reaching up to 88.46% SSIM and 26.09 dB PSNR, with consistent improvements over baselines. Notably, our diffusion process requires only 4 steps, making it computationally efficient while maintaining high-quality synthesis. To further validate generalizability, we test Prob-BBDM on an external third-party dataset, demonstrating consistent performance across domains. Additionally, we assess the clinical utility of the synthesized slices by using them as input to a pre-trained segmentation model. Tumor segmentation yields a Dice score of 88.71% and an HD95 of 3.49 mm, confirming that the synthesized slices preserve critical diagnostic information. These results highlight the potential of Prob-BBDM for high-quality, efficient, and generalizable MRI synthesis, offering a promising step toward improved medical image translation.

Unlearning has emerged as a key technique to mitigate harmful content generation in diffusion models. However, existing methods often remove not only the target concept, but also benign co-occurring concepts. As illustrated in Fig.1, unlearning nudity can unintentionally suppress the concept of person, preventing a model from generating images with person. We define these undesirably suppressed co-occurring concepts that must be preserved CARE (Co-occurring Associated REtained concepts). Then, we introduce the CARE score, a general metric that directly quantifies their preservation across unlearning tasks. With this foundation, we propose ReCARE (Robust erasure for CARE), a framework that explicitly safeguards CARE while erasing only the target concept. ReCARE automatically constructs the CARE-set, a curated vocabulary of benign co-occurring tokens extracted from target images, and leverages this vocabulary during training for stable unlearning. Extensive experiments across various target concepts (Nudity, Van Gogh style, and Tench object) demonstrate that ReCARE achieves overall state-of-the-art performance in balancing robust concept erasure, overall utility, and CARE preservation.

The space $\mathcal{P}_2(\mathbb{R}^d$) of probability measures with finite second moment carries a natural geometry: the quadratic Wasserstein distance W_2 makes it a complete metric space and, following Otto, a (formal) Riemannian manifold whose geodesics are the optimal-transport interpolations. On this manifold, the gradient flow of the free energy F(rho) = KL(rho || π) is exactly the Fokker-Planck equation, and its implicit-Euler discretization is the JKO scheme. This is the geometry underlying diffusion models: the forward process descends the free energy, and each denoising step realizes one JKO step, which recovers DDPM, DDIM, NCSN/SMLD, and Energy Matching; this is one scheme, not separate theories. The same manifold supports a second variational principle. Its geodesics - the minimum-action curves of the Benamou-Brenier formula - are precisely the optimal-transport paths that Flow Matching learns. Fixing both endpoints and following the geodesic, generation becomes a deterministic ODE along a straight line, hence far fewer sampling steps. Placing both families of models on one manifold makes their relationship exact: diffusion follows a free-energy gradient flow, an initial-value problem; optimal-transport Flow Matching follows a Wasserstein geodesic, a boundary-value problem. The two reach the same endpoints along different paths.

We introduce cyclic denoising -- repeated forward and reverse diffusion at controlled noise amplitudes -- as an extraction attack for image diffusion models. Inspired by random organization in disordered solids, cyclic denoising exposes regions of the learned distribution that are largely inaccessible to standard sampling. The dynamics drive samples toward attractors with a broad stability spectrum. The deepest attractors are ultrastable: they regenerate after near-total corruption and persist through thousands of noising-denoising cycles. Many of these attractors correspond to memorized training images, including stock photographs, brand watermarks, and web-crawl artifacts. The attack requires only sampler-level control, with no gradients, weight inspection, prompts, captions, or prior knowledge of the training data. Unlike generate-and-filter attacks, which rely on large-scale prompted generation and post-hoc similarity or membership-inference filtering, our main protocol is fully unconditioned. We demonstrate the phenomenon in Stable Diffusion v1.4 and in a pixel-space DDPM, showing consistent behavior across latent- and pixel-space diffusion models. Across noise amplitudes, we observe a yielding-like transition: low-amplitude cycling produces trivial absorbing fixed points or limit cycles, while larger amplitudes induce rearrangements, basin hopping, and long-lived trapping in structured memorized attractor basins. We also observe hierarchical partial absorption, prompt-stabilized basins, and cross-initial-condition universality of the recovered attractor set. Our results therefore show that cyclic denoising is both a physics-inspired probe of generative landscapes and a practical tool for memorization auditing, with implications for privacy, copyright compliance, and model fingerprinting.

Generative molecular models for drug design are a promising direction with much active research. In the next phase of computational drug design, such models will need to understand small molecule structure and protein-ligand interactions, and they will need to possess the machinery to generate molecules de novo. Incorporating each feature poses a critical challenge. Equally important, yet often treated as secondary, is the ability to grow a molecule from a partial starting point -- a scaffold or fragment supplied by a chemist -- which is the central operation of lead optimization. We present Sesame (Spatial Evoformer for a Structure-Aware Molecular Engine), a diffusion-based molecular generation model that leverages a novel spatial pairformer module to condition on partial molecular structure and the surrounding protein pocket, both expressed as continuous spatial density maps. This single conditioning mechanism supports both de novo generation and fragment-conditioned lead optimization, letting a medicinal chemist prune a hit to a scaffold and have Sesame grow it in productive ways. In addition to this module, we also introduce a diffusion framework for joint denoising of atom types, bond types, and positions, along with a trajectory finetuning scheme that trains on the model's own sampling rollouts to improve generation quality. Sesame is trained on a large corpus of ligand-only and protein-ligand datasets.

Generating human-object interactions (HOI) is central to character animation, robotics, AR/VR, and embodied AI. Recent HOI generation methods synthesize motion from text, object geometry, and sparse waypoints, controlling action semantics and object trajectories. However, these signals underspecify interaction: the same prompt and trajectory can produce different grasps, approach directions, body poses, object poses, contacts, and body-object layouts. We address this ambiguity with a reference image as a visual specification of the desired interaction snapshot. However, a single global image representation conflates distinct cues and conditions all frames on identical visual evidence. We therefore introduce IMAGIN-4D, a diffusion-based HOI generator that decomposes image conditioning spatio-temporally. For spatial conditioning, IMAGIN-4D extracts supervised interaction-state tokens for body pose, object pose, body-object contact, and spatial relationships at the depicted frame. For temporal conditioning, it computes frame-aware tokens by querying image patches per generated frame, allowing sequence segments to attend to different visual cues from the same image. To balance image, text, and waypoint cues, IMAGIN-4D uses role-aware conditioning: text, waypoints, and interaction-state tokens use separate AdaLN streams, while frame-aware visual tokens cross-attend with motion tokens. Since HOI motion datasets lack paired images, we build a synthetic motion-to-image rendering pipeline from FullBodyManipulation (FBM) and introduce an image-adherence metric to evaluate whether generated motions match the reference snapshot. Experiments on FBM and BEHAVE show that IMAGIN-4D improves fine-grained interaction control over single-token and uniformly image-conditioned baselines while preserving waypoint-following and motion quality. Code and models will be released at https://imagin4d.github.io.

Diffusion models (DMs), despite their impressive capabilities across a wide range of generative tasks, have been shown to be vulnerable to backdoor attacks. However, existing backdoor methods face critical trade-offs among key factors: attack performance, stealthiness, time complexity, and required poison rates. For example, achieving high attack performance typically demands a high poison rate and prolonged training, which undermines stealthiness, making the attack more detectable by backdoor defenses. This paper proposes TooBad (trigger optimization for backdoor diffusion models), a backdoor framework which introduces a novel DM-tailored trigger optimization technique to dramatically enhance the performance of backdoor attacks on DMs. Experiments on representative benchmarks such as CIFAR-10 show that TooBad can achieve high ASRs ($> 85$%) at only 0.5% poison rate, significantly lower than the 10% typically required by prior work on the same datasets. At 5% poison rate, TooBad reaches nearly 100% ASR within just 3-5 backdoor injection epochs, whereas existing methods need at least 30-50 epochs at double the poison rate for comparable results. Despite its potency, TooBad easily evades SOTA defenses and maintains high utility. These results reveal a critical threat on DMs and highlight the need for more robust defenses against such stealthy yet efficient attacks.

Training Latent Diffusion Models (LDMs) within Federated Learning (FL) has attracted increasing attention due to its ability to combine the powerful generative capacity of LDMs with the privacy-preserving properties of FL. However, FL requires sharing the global model with multiple participants, which risks unauthorized model distribution or resale by malicious clients. While an intuitive approach is to adopt existing VAE-based watermarking techniques for LDMs in FL, this strategy falls short in addressing such threats due to two fundamental challenges: (1) Existing methods support ownership verification but lack the ability to trace model leakage to a specific malicious client; (2) VAE-based watermarks are vulnerable, as they can be removed simply by replacing the decoder with a clean counterpart. In this paper, we propose FedOT, the first framework for ownership verification and leakage tracing in federated LDMs. Specifically, to address the first challenge, we design a chunked watermark, where the first part is for ownership verification, and the second part is used for client identification. Furthermore, to overcome the second challenge and secure the model against VAE replacement attack, we introduce Latent Vector Transformation (LVT), which strengthens the connection between the VAE and U-Net latent spaces by modifying the original latent distribution of the VAE. Consequently, any attempt to replace the VAE for watermark removal leads to significant image quality degradation, making the LDM model unusable. Extensive experiments demonstrate that FedOT achieves superior performance in both ownership verification and traceability. Project page: https://spyzixuan.github.io/FedOT/.

Synthesizing realistic Human-Object Interactions (HOI) is critical for creating embodied avatars and functional virtual environments. However, current data-driven approaches primarily rely on motion capture datasets, which are expensive to scale and limited in functional diversity. Models trained with these datasets fail to generalize to unseen objects and maintain physical consistency over long horizons. In this paper, we propose a novel framework that leverages a physics simulator to overcome the data-scarcity bottleneck in HOI generation. Specifically, we propose a scalable pipeline, called \ours, which leverages policies trained with reinforcement learning in a physics simulator for task-oriented data generation and trains a generative model on the augmented dataset for generalizable HOI generation. To seamlessly utilize the synthetic data, we introduce a coarse-to-fine retargeting process that bridges the representation gap between the simplified model used in physics simulator and the standard parametric body models required for generative training. Validated through comprehensive experiments, our method demonstrates enhanced generalization to unseen objects and the capability of long-horizon generation, while exhibiting greater dynamic diversity and physical plausibility.

Traditional supervised methods for structured visual recognition tasks -- such as object detection, segmentation, and scene graph generation -- often produce deterministic, fixed outputs, limiting their ability to capture the inherent uncertainty in complex visual scenes. As a consequence, such point estimates are unable to capture the prediction uncertainty (or multi modality) intrinsic to these problems, often arising from natural ambiguities (e.g., ambiguity in size of partially occluded objects, local ambiguity of exact segmentation boundary, etc.) as well as noise and sparsity of training data. To address this limitation, we present Modular Diffusion Models (MDMs), a simple and novel framework that learns a distribution over structured outputs for a given input image. MDMs decompose the diffusion process into distinct, task-specific modules, each focused on capturing a different aspect of the structured information space, such as object categories, spatial locations, and inter-object relationships. This modular design allows each component to be learned independently, with seamless integration at inference without additional training. Furthermore, the modularity of MDMs enables the diffusion process to easily operate over the heterogeneous output space common in many structured learning tasks (e.g., a continuous bounding boxes and discrete class labels). Experimental results over three distinct structured tasks -- object detection, instance segmentation, and scene graph generation -- highlight the benefits of our proposed framework.

We show that replacing the standard MSE denoising loss in diffusion models with a nonlinear transformation induced by an f-divergence yields a simple robust training surrogate that empirically improves performance under data contamination, with small additional computational overhead. The theoretical foundation rests on a local divergence construction: under the Gaussian reverse-kernel structure of DDPM, each per-step likelihood ratio follows a lognormal distribution parameterized by a scalar mismatch, so the conditional f-divergence at each step reduces to a one-dimensional function of the denoising error. Summing these local divergences yields a training objective that unifies diffusion training as divergence induced weighted denoising, where the derivative of the induced divergence acts as a residual-space influence weight that controls the contribution of each sample. Bounded-influence divergences (Hellinger, negative exponential) suppress large error samples, with Hellinger yielding an explicit exponential weight, connecting the framework to robust M-estimation. Empirically, on CIFAR-10 under 30% contamination, NED reduces FID from 93.0 (KL) to 77.5, while also outperforming standard robust losses such as Huber and clipped MSE.

While federated learning enables collaborative modelling on decentralised data, standard methods merely fit historical observations. This purely observational approach is fundamentally insufficient for interventional inference and policy evaluation, as sequential actions dynamically alter future states. We propose Fed-CausalDiff, a federated causal diffusion framework for do-simulation. The architecture decomposes the evolution of the latent state into a global causal score function and a local confounding score function. This design enables decoupled synchronisation (DSS), where clients aggregate only the shared causal mechanism while retaining site-specific confounders locally to handle heterogeneity. Experiments on four datasets demonstrate that Fed-CausalDiff achieves better ATE and policy-value estimation accuracy, offering a favorable trade-off between communication cost and inference fidelity.

Recent generative video compression methods leverage powerful generative priors to achieve perceptually pleasing reconstructions. However, most existing approaches require additional training to adapt generative models to produce realistic reconstructions from compact representations. In this paper, we propose ZeroGVC, a zero-shot generative video compression framework that leverages pretrained autoregressive diffusion priors for low-delay video reconstruction. ZeroGVC encodes the first frame of each group of pictures (GOP) with an image codec and represents subsequent P-frames through Codebook-Guided Autoregressive Latent Compression. This design is motivated by our observation that the compression scheme of denoising diffusion codebook models is effective in few-step consistency sampling. By selecting compact combinations of reproducible codebook noise vectors, ZeroGVC steers the latent denoising trajectory toward the target P-frame while allowing the decoder to reproduce the same trajectory in only a few denoising steps. In addition, we design an optional bidirectional reference mode that mitigates error propagation by leveraging the next I-frame context without introducing any additional bitrate overhead. Extensive experiments on standard video compression benchmarks demonstrate that ZeroGVC achieves superior perceptual reconstruction quality at ultra-low bitrates without any additional training.

While longitudinal brain PET imaging is the gold standard for quantifying the spatiotemporal accumulation of Beta-amyloid, its widespread clinical utility is constrained by high operational costs and cumulative radiation risks. Recent deep generative models show promise in longitudinal image synthesis; however, they often fail to capture subtle pathological progression due to identity drift and a persistent bias toward trivially replicating baseline signal intensities rather than modeling temporal transition. To this end, we propose Delta-Diffusion, a novel progression-aware framework that redefines longitudinal PET synthesis as a conditional Poisson Diffusion Bridge (PDB) process. Unlike standard diffusion models that start from Gaussian noise, our PDB formulation is mathematically anchored to the subject's baseline PET, effectively transforming the generative task into a conditional distribution transition of the amyloid trajectory. To handle heteroscedastic nature of PET imaging, we introduce a physically-grounded Poisson perturbation within a Diffusion Transformer (DiT). This architecture uses adaptive scale-shift modulation to precisely calibrate the synthesis with the elapsed clinical interval and structural MRI context. A volume-of-interest balanced objective is designed to emphasize sparse, high-risk regions of amyloid accumulation. Validated on two cohorts with 542 subjects, Delta-Diffusion demonstrates superior performance in capturing longitudinal variations in amyloid deposition compared to state-of-the-art methods, offering a robust computational framework for tracking disease progression.

Diffusion models excel at capturing multi-modal action distributions in robot imitation learning. However, in multi-task and long-horizon scenarios, monolithic architectures lack structural generalization capabilities, suffering from gradient conflicts between distinct semantic sub-stages. While pure data-driven Mixture-of-Experts (MoE) methods introduce labor division, they frequently trigger routing collapse, and instantiating full-scale experts causes parameter explosion and high expansion costs. To address these issues, we propose Concept-prior Routed Diffusion Experts (CoRDE), a structure-guided variational distillation framework. CoRDE extracts semantic distributions from a frozen concept encoder to guide the variational posterior responsibility via a learnable soft mapping matrix. This mechanism introduces an entropy-controlled responsibility inference process that encourages confident routing under reliable semantic predictions while preserving the stochastic diffusion term for behavioral diversity. To overcome parameter inflation, CoRDE employs a parameter-efficient expert pool using Low-Rank Adaptation (LoRA) on a shared frozen backbone. Theoretical analysis shows that the mixture score discrepancy is bounded by responsibility-weighted local expert errors, supporting high-fidelity generation under low-rank expert adaptation. Empirical evaluations confirm that, compared to existing baselines, CoRDE systematically reduces routing collapse, forming robust, semantically aligned expert allocations while achieving superior action quality and incremental learning efficiency.

To generate natural and accurate sentence-level sign language, synthesizing the "gloss", the fundamental semantic unit, is essential. However, most current sign-language production (SLP) methods generate entire sequences at once. While this end-to-end approach is often efficient, it is prone to temporal drift and hand motion blur as sentences get longer, and fails to accurately control individual glosses. In this paper, we propose the Context-aware Gloss-wise AutoRegressive Diffusion model (GARD), a gloss-wise diffusion framework that models coarticulation by conditioning on both semantic (linguistic) and kinematic (motion) contexts. To ensure natural continuity between gloss motions, GARD introduces two additional strategies: i) Inter-Gloss Transition Guidance, which applies gradient-based guidance to kinematically align inter-gloss boundaries and ensure seamless pose consistency. ii) Global Motion Harmonizer, refining the entire gloss motion sequence based on the boundary poses adjusted by Inter-Gloss Transition Guidance. Extensive experiments on Phoenix-T and CSL-Daily datasets demonstrate that GARD achieves superior performance over existing SLP methods in terms of both linguistic accuracy and motion similarity.

Molecular docking requires reasoning jointly about ligand pose and protein flexibility. Most diffusion-based docking models predict torsional updates with generic Euclidean heads that ignore the periodic geometry of angular variables. This mismatch is especially limiting in flexible docking, where ligand conformations and pocket side chains co-adapt to form the bound complex. Here, we introduce Harmony, a harmonic torsional diffusion framework for flexible protein-ligand docking. Harmony parameterizes ligand and side-chain torsional score fields as derivatives of learned harmonic potentials on the circle, which are noised mode by mode in the Fourier basis owing to the properties of variance-exploding diffusion on the torus. This construction makes periodicity explicit and gives the model a frequency-aware inductive bias over rotameric motion. On the PDBBind benchmark, Harmony improves ligand pose accuracy and pocket all-atom reconstruction over recent flexible docking methods. On PoseBusters, it improves the physical validity of generated complexes. Case studies on EBNA1 and KRAS G12D illustrate the method's behavior on a polar and a shallow binding site, respectively. Together, these results indicate that aligning the score parameterization with the geometry of the diffusion process is a simple and effective lever for improving flexible docking.

Creating 3D visual illusions, a single 3D mesh that reveals entirely different semantics from various viewing angles, is a fascinating but tough challenge. Existing optimization-based methods are slow and can produce oversaturated colors. In contrast, naive stitching approaches fail to produce geometrically coherent objects. This results in visible unnatural seams and semantic leaks. In this paper, we present a fast and training-free framework for generating text-driven 3D visual illusions. Our approach decouples the generation into two stages. First, we propose a cross-space dual-branch denoising process. This process dynamically decodes 3D latents into voxel space for CLIP-guided orientation alignment and Signed Distance Field (SDF) blending, which ensures seamless geometric fusion. Second, we introduce a view-conditioned texture synthesis module that projects and aggregates view-specific 2D diffusion priors onto the fused geometry. Extensive experiments demonstrate that our method generates highly realistic, dual-semantic 3D illusions in just 3-5 minutes. It significantly outperforms existing methods in geometric integrity, semantic recognizability, and efficiency. Project page: https://siang1105.github.io/JanusMesh.github.io/

Diffusion models rely heavily on explicit timestep embeddings to modulate the denoising process across various noise scales. In this work, we challenge the necessity of these temporal signals by analyzing their impact on U-Net and Diffusion Transformer architectures. Beyond empirical evidence, we provide a theoretical framework demonstrating that, under certain conditions, the global minimizer of the diffusion training objective can be achieved without explicit timestep conditioning. Our findings reveal a surprising robustness when timestep embeddings are completely removed. Extensive ablation studies on the CelebA and CIFAR-10 datasets show that these time-agnostic models can maintain high structural fidelity and even surpass their conditioned counterparts in competitive metrics, including FID, precision, and recall. Our analysis suggests these architectures can implicitly infer noise scales from the corrupted input under specific assumptions, rendering explicit temporal conditioning redundant. This study challenges long-standing temporal conditioning paradigms and paves the way for more efficient and structurally focused generative architectures.