Multimodal Learning

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Overview

Multimodal learning asks how information from different sources can be combined to improve tasks such as diagnosis, retrieval, forecasting, and robot perception. Common approaches include feature fusion and cross-attention, contrastive alignment, self-supervised pretraining, and mixture-of-experts models that balance shared information with modality-specific cues. Foundation models increasingly support understanding and generation across several modalities, while domain-specific systems use paired or partially paired data and may use extra inputs during training even when they are unavailable at deployment. A central tension is that modalities can complement one another but can also be missing, noisy, misaligned, or unevenly used, so research focuses on robust fusion and evaluations that test whether models truly rely on the relevant evidence.

Latest papers

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338 papers38 papers in the last four weeks, down 5% on the four weeks before. 0.2% of all new papers.

Jun 15, 2026

3D Classification of Paramagnetic Rim Lesions in Multiple Sclerosis via Asymmetric QSM-FLAIR Modeling

Paramagnetic rim lesions (Rim+^+) identified on susceptibility-sensitive MRI have recently emerged as a specific biomarker of chronic active inflammation in Multiple Sclerosis (MS) and are associated with long-term disability progression. However, susceptibility imaging and expert interpretation remain limited to specialized centers, visual assessment is time-consuming and variable, and the low prevalence of Rim+^+ lesions poses severe class imbalance challenges for automated analysis. We propose a 3D multimodal deep learning framework for lesion-level Rim+^+/Rim−^- classification from Quantitative Susceptibility Mapping (QSM) and FLAIR MRI. The architecture explicitly models modality asymmetry by treating QSM as the primary susceptibility-driven signal and conditioning it with FLAIR-derived structural context. To improve robustness under limited data, we employ self-supervised multimodal pretraining followed by supervised fine-tuning with contrastive regularization. The method was evaluated on a clinically acquired cohort of 88 people with MS with expert lesion annotations as reference standard. Results highlight improved performance compared to prior architectures, supporting the effectiveness of asymmetric multimodal modeling for automated chronic active lesion identification.

Veronica Pignedoli, Giacomo Boffa, Nicoletta Noceti +3

MaLGa, DIBRIS, University of Genova, Genova, Italy · DINOGMI, University of Genova, Genova, Italy · IRCCS Azienda Ospedaliera Metropolitana, Genova, Italy

Medical Image ClassificationBrain MRIMultimodal Learning
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Jun 15, 2026

SPICE: Synergy and Partial Information Based Curriculum Evolution

Multimodal learning exploits complementary information across heterogeneous modalities. The informativeness of each modality can vary widely across samples and training stages. Existing multimodal curriculum learning strategies often assume that the relative complexity of samples remains unchanged throughout training and therefore cannot adapt to model evolution. We propose SPICE (Synergy and Partial Information based Curriculum Evolution), a novel progressive curriculum framework for multimodal interaction learning. Guided by Partial Information Decomposition (PID) theory, our approach decomposes multimodal interactions into redundant, unique, and synergistic information components, enabling an interpretable and dynamic characterization of sample complexity. Building on this decomposition, we design a progressive curriculum that evolves throughout training, allowing the model to transition from learning shared cross-modal cues to modality-specific patterns and, finally, to complex synergistic interactions. Adapting to model evolution, sample ordering is refined in real-time using PID information estimates derived from unimodal and multimodal predictions. Experiments across multiple multimodal benchmarks demonstrate consistent improvements over conventional training and state-of-the-art baselines, highlighting the effectiveness of PID information decomposition and adaptive sample ordering for multimodal curriculum learning.

Ankush Pratap Singh, Houwei Cao, Yong Liu

New York Institute of Technology · New York, NY, USA · New York University

Curriculum LearningMultimodal LearningMultimodal Understanding
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Jun 15, 2026

MUNI: Multimodal Unified Latent Diffusion for Coherent Any-to-Any Generation

We introduce MUNI, an end-to-end multimodal latent diffusion framework for any-to-any generation that unifies subset-conditioned cross-modal generation and unconditional joint sampling through a shared stochastic latent. Existing multimodal generative models are largely LLM-based, which limits leveraging modality-specific generators and requires text-paired data for training. Recent diffusion- and flow-based any-to-any extensions take a different direction but still rely on text-aligned embeddings, fully-paired training, or matched-dimensionality deterministic mappings. MUNI rests on two complementary contributions, one architectural and one in the training objective. First, we extend latent diffusion to multimodal any-to-any generation end-to-end: instead of the standard two-stage recipe that precomputes a frozen latent space and then fits a prior over it, MUNI jointly trains modality-specific encoders, expressive decoders, and a single shared flow-based prior under one objective. Second, we identify that the standard aggregation rules of multimodal variational inference are insufficient once coupled with a learned prior and expressive decoders. A suitable shared latent must simultaneously satisfy coherence across generated modalities, predictive sufficiency of subset latents, and minimality of the latent content. We propose a routed training objective whose structural choices align the latent with these criteria and admit a minimal-sufficiency characterization in the realizable setting. Experiments on PolyMNIST-Quadrant-Labels and a large-scale image-text-audio benchmark show MUNI matching or exceeding the strongest baselines on conditional generation while opening its largest margins on unconditional coherence. Project page: https://muni-proj.github.io/.

Kyeongmin Yeo, Yunhong Min, Minhyuk Sung

KAIST

Latent Diffusion ModelsMultimodal GenerationMultimodal LearningMultimodal Diffusion Models
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Jun 15, 2026

DynFS-MoE: Dynamic Functional-Structural Mixture-of-Experts for Post-Traumatic Epilepsy Diagnosis

Post-traumatic epilepsy (PTE) is a severe complication of traumatic brain injury (TBI). Yet, early identification remains challenging due to the complex structural and functional alterations it induces in the brain. To address this, we propose a dynamic multimodal Mixture-of-Experts (MoE) framework that integrates functional and structural connectivity through time-aware functional-structural encoding and class-conditioned expert routing. Within this framework, modality-specific and cross-modal experts learn complementary representations, while a Modality-Class MoE (MCoE) module dynamically adjusts expert weights according to each classification objective. Experimental results across three binary classification tasks demonstrate that the framework consistently outperforms static fusion baselines, and high-interpretability analyses further reveal meaningful regions of interest (ROIs) interactions. This dynamic multimodal expert framework effectively captures class-dependent brain interaction patterns and provides an interpretable approach for PTE diagnosis and risk stratification.

Jun-En Ding, Spencer Chen, Henry Noren +6

Department of Industrial and Systems Engineering, Rutgers University, Piscataway, NJ, USA · Department of Systems Engineering, Stevens Institute of Technology, Hoboken, NJ, USA · Department of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA

Medical DiagnosisNeuroimagingMixture-of-Experts ModelsMultimodal Learning
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Jun 14, 2026

Unsupervised Learning for Missing Modalities in Multimodal Learning

This paper addresses the missing-modality challenge in multi-modal learning by introducing Unsupervised Learning for Missing Modalities in Multi-Modal Learning (UL4M4), a flexible framework that imputes missing feature embeddings in a task-independent manner before supervised prediction. We propose modality-specific normalization and a novel partial-modality distance metric to enable fair clustering of incomplete observations, capturing cross-modal structures while preserving scale-invariance across varying dimensionalities and modality counts. Cluster centers from this unsupervised stage guide an iterative greedy imputation process for any missing modalities during training or inference, supporting arbitrary numbers of modalities and arbitrary missing patterns per sample. The imputation module is lightweight, uses frozen encoders, and decouples from the downstream task, allowing easy integration with any fusion/prediction architecture. Extensive experiments under diverse and highly incomplete regimes demonstrate UL4M4's robustness, achieving, to the best of our knowledge, the first consistent F1-Micro scores above 0.7 on challenging missing configurations even when more than 50% of modality slots are missing. Results are also stable across cluster sizes and significantly outperform state-of-the-art baselines. Code is available here: https://github.com/h-ismkhan/Multimodal-Learning-with-Missing-Modalities-via-Unsupervised-Learning.

Hassan Ismkhan, Hamid Bouchahcia

Bournemouth University Bournemouth, UK

Missing-Modality LearningUnsupervised LearningLearning with Missing DataMultimodal Learning
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Jun 13, 2026

When the Same Musical Knowledge Forgets Differently: A Clean Probe of Pathway-Dependent Forgetting

A model can learn that the piano piece Für Elise is calm and reflective by listening to the audio or by reading a text description, but does it matter which route that knowledge took when it is later at risk of being forgotten? Forgetting research in multimodal models measures what knowledge is lost under adaptation, yet has not asked whether acquisition route affects how easily that knowledge is forgotten. We call this untested premise the Pathway-Invariant Assumption. Music understanding enables a clean test because a music clip and a canonical text description can be aligned to the same perceptual content, allowing the same knowledge unit to enter a model through listening or reading while the target remains fixed. Across multiple architecturally distinct audio-language models, we observe a consistent asymmetry: text-pathway knowledge is forgotten more than matched audio-pathway knowledge under identical adaptation pressure. To attribute this effect to route rather than confounds, we introduce the Paired Pathway Controlled Protocol (PPCP), a three-phase design that establishes matched pathway baselines, activates both pathways under symmetric supervision on the same knowledge pool, and applies identical forgetting pressure to both pathways. The gap is stable across models and gain-controlled analyses, persists when contradictory overwrite is replaced by correct-label cross-domain learning, remains under single-modality pressure, and is not removed by lightweight replay. Two independent routing-depth controls confirm that the effect is not explained by architectural depth, pointing to input representation as the dominant factor. Under PPCP, our results demonstrate that forgetting is highly route-dependent, establishing acquisition route as a new analytical dimension for forgetting research and multimodal system design.

Yu Liu, Zhiwei Yang, Wenxiao Zhang +8

Institute of Information Engineering, CAS · School of Cyber Security, UCAS · The University of Western Australia +1

Music UnderstandingAudio-Language ModelsMultimodal LearningCatastrophic Forgetting
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Jun 10, 2026

Multimodal Ordinal Modeling of Alzheimer's Disease Severity Using Structural MRI and Clinical Data

Neurodegenerative diseases such as Alzheimer's disease (AD) require accurate and scalable tools for assessing disease severity, yet current clinical staging remains time-intensive and prone to variability. We propose an attention-enhanced multimodal machine learning framework with ordinal regression for automated and interpretable AD severity staging. The framework integrates T1-weighted MRI with demographic and genetic variables and compares unimodal and multimodal architectures using ordinal and non-ordinal prediction heads. Models were trained and validated using cohort-stratified splits derived from the ADNI, AIBL, and NIFD datasets. A strictly held-out test set was constructed using subjects excluded from all training, validation, preprocessing, and hyperparameter tuning procedures, with subject-level splitting employed throughout to prevent data leakage. Among unimodal approaches, the T1-weighted MRI model achieved slightly higher adjacent-stage accuracy (0.963) and agreement with clinical staging (QWK 0.444) than the tabular model (QWK 0.433). Integrating imaging, demographic, and genetic information improved overall performance. The multimodal non-ordinal baseline achieved the lowest prediction error (MAE 0.340), whereas the ordinal multimodal model achieved the highest adjacent-stage accuracy (0.970) and strongest agreement with clinical staging (QWK 0.549). These findings indicate that ordinal formulations better capture the ordered structure of the CDR scale and yield predictions more consistent with clinical staging. Explainability analyses using Grad CAM++ and SHAP demonstrated anatomically and clinically plausible model behavior, supporting transparent decision-making. Overall, attention-based multimodal learning with ordinal regression represents a robust, interpretable, and scalable approach for automated AD severity staging and AI-assisted clinical decision support.

Boris-Stephan Rauchmann, Jonathan Laib, Buse Ercik +2

Department of Neuroradiology, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany · Department of Psychiatry and Psychotherapy, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany

Alzheimer's DiseaseMedical Image ClassificationOrdinal RegressionMultimodal Learning
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Jun 10, 2026

Parameter-Efficient Adapter Tuning for Tabular-Image Multimodal Learning

Tabular-image multimodal learning aims to improve predictive modeling by jointly using structured tabular attributes and visual data. Although pretrained encoders provide strong modality-specific representations, full fine-tuning can be computationally expensive, while keeping encoders frozen may limit task-specific adaptation. We propose the Tabular-Image Adapter (TI-Adapter), a modality-specific adapter-based fine-tuning framework for efficient multimodal adaptation. TI-Adapter freezes the pretrained tabular encoder and learns an adapter after the extracted tabular embedding, while adapting the image branch with embedding-level and bottleneck-level adapters instead of full fine-tuning. Experiments on 20 tabular-image datasets show that TI-Adapter achieves competitive or better predictive performance than full fine-tuning while using substantially fewer trainable parameters. Ablation studies further demonstrate the importance of adapter placement for balancing performance and practical efficiency.

Jiaqi Luo

School of Mathematical Sciences, Soochow University, No.1 Shizi Street, Suzhou, 215006, Jiangsu Province, China

Fine-TuningAdapter TuningTabular MLMultimodal LearningParameter-Efficient Fine-Tuning
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Jun 10, 2026

Information-Theoretic Decomposition for Multimodal Interaction Learning

Multimodal learning hinges on capturing redundant, unique, and synergistic information across modalities, which collectively constitute multimodal interactions. A critical yet underexplored challenge is that these implicit interactions vary dynamically across samples. In this work, we present the first systematic, information-theoretic analysis highlighting why learning these dynamic, sample-specific interactions is critical for effective multimodal learning. Our analysis further reveals deficits in conventional paradigms at learning these distinct interaction types: modality ensemble approaches struggle to capture synergy, while joint learning paradigms often under-utilize redundant information. This highlights the need for an approach that can adaptively learn from different interaction types on a per-sample basis. To this end, we propose Decomposition-based Multimodal Interaction Learning (DMIL), a novel paradigm that explicitly models and learns from sample-specific interactions. First, we design a variational decomposition architecture to isolate the constituent interaction components. Second, we employ a new learning strategy that leverages these explicit interaction components in a fine-tuning process to achieve comprehensive interaction learning. Extensive experiments across diverse tasks and architectures demonstrate that DMIL consistently achieves superior performance by adapting to holistic sample-specific interactions. Our framework is flexible and broadly applicable, establishing an interaction-centric paradigm for multimodal learning. The code is available at https://github.com/GeWu-Lab/DMIL.

Zequn Yang, Yake Wei, Haotian Ni +2

Gaoling School of Artificial Intelligence, Renmin University of China, Beijing · Beijing Key Laboratory of Research on Large Models and Intelligent Governance · Engineering Research Center of Next-Generation Intelligent Search and Recommendation, MOE +2

Multimodal FusionMultimodal LearningMultimodal Understanding
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Jun 8, 2026

RespiraMFM: A Multimodal Foundation Model with Contrastive Audio-Language Alignment for Respiratory Disease Identification

Respiratory diseases remain a leading cause of global mortality, where timely and accurate diagnosis is critical to improving patient outcomes and reducing healthcare burdens. While prior work has explored audio-based models for respiratory disease detection, such unimodal approaches often suffer from limited generalizability and diagnostic precision. In this paper, we propose RespiraMFM, a Multimodal Foundation Model that integrates respiratory sounds with patient medical history and symptoms to enhance diagnostic accuracy and disease detection capabilities. We introduce an effective contrastive alignment strategy for audio-text multimodal integration, allowing the model to learn better cross-modal representations between respiratory sounds and corresponding textual clinical information. We evaluate RespiraMFM across five major respiratory diseases using seven real-world datasets in both supervised fine-tuning and zero-shot settings, achieving a 9.15% improvement in AUROC on supervised tasks and a 20.98% gain on zero-shot tasks over existing baselines. These findings underscore the potential of our framework to advance early diagnosis and improve clinical decision-making in respiratory disease management.

Shakhrul Iman Siam, Tiantian Feng, Jiankun Zhang +2

The Ohio State University · University of Southern California · University of Chicago

HealthcareAudio-Language ModelsMultimodal Foundation ModelsMultimodal Contrastive LearningAudio ClassificationMultimodal Learning+1
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Jun 6, 2026

Test-Time Scaling in Multimodal Foundation Models: A Comprehensive Survey of Generation and Reasoning

Test-time Scaling (TTS) has emerged as a pivotal research direction for enhancing model performance by dynamically allocating computational resources during inference. Recent advancements have adapted this paradigm to Multimodal Foundation Models (MFMs), unlocking their potential in multimodal reasoning and generation. Despite rapid progress, the field lacks a systematic survey and unified theoretical framework to delineate the developmental landscape of multimodal TTS. To bridge this gap, we present the first comprehensive review of TTS research for MFMs, proposing a unified taxonomic framework that categorizes existing methodologies into three distinct strategies: sampling-based, feedback-based, and search-based approaches. We further summarize representative applications and benchmarks commonly utilized to evaluate multimodal TTS capabilities in generation and reasoning tasks. Finally, this survey discusses open challenges and outlines future research directions, providing a systematic roadmap for subsequent studies in this rapidly evolving field.

Cong Wan, Ying He, Zhongzhan Huang +1

Sun Yat-sen University

Test-Time ScalingMultimodal ReasoningMultimodal GenerationMultimodal Foundation ModelsMultimodal Learning
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Jun 6, 2026

LongMoE: Longitudinal Multimodal Learning via Trajectory-Aware Mixture-of-Experts

Multimodal clinical learning is increasingly important for integrating diverse patient data, including imaging, text, and personalised health records. However, it faces two fundamental challenges: i) modality missingness, where arbitrary subsets of modalities are unavailable at a given patient visit, ii) longitudinal dynamics, where the diagnostic significance of an observation depends on the patient's evolving disease trajectory over time. Existing methods address these challenges in isolation: missing-modality frameworks treat each visit as an independent static snapshot and discard temporal context, while longitudinal models often assume complete modality availability and degrade under systematic modality incompleteness. We propose LongMoE (Longitudinal Mixture-of-Experts), the unified framework to jointly address both challenges. LongMoE combines a context-aware imputation module with an attentional tokenization module that captures frequency-domain temporal patterns across irregular visit sequences, a trajectory-aware encoder for modeling disease progression, and context-conditioned Sparse MoE routing for patient-specific expert selection. Experiments on ADNI, OASIS-3, and MIMIC-IV show that LongMoE improves robustness under missing or weak contemporaneous modalities and remains competitive in full-modality settings, establishing a strong foundation for longitudinally-aware multimodal clinical learning.

Maxx Richard Rahman, Prakhar Kumar, Wolfgang Maass

German Research Centre for Artificial Intelligence (DFKI) Saarbrücken, Germany

Missing-Modality LearningMultimodal RobustnessMixture-of-Experts ModelsLongitudinal EHR ModelingMultimodal Learning
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Jun 5, 2026

Federated Foundation Models over Vehicular Networks

This paper presents a forward-looking vision for integrating the emerging multi-modal multi-task federated foundation models (M3T FedFMs) into vehicular networks, with the goal of unifying the expressive power of multi-modal multi-task foundation models (M3T FMs) with the privacy-preserving and distributed learning capabilities of federated learning (FL). Given the largely underexplored nature of this research direction, we first introduce the fundamental training/fine-tuning principles of M3T FedFMs. We then discuss a range of their representative use cases in vehicular networks, illustrating the significant potential of M3T FedFMs to enable next-generation vehicular intelligence. Afterwards, we identify key constraints inherent to vehicular environments that challenge the practical deployment of M3T FedFMs, and articulate a set of forward-looking research directions to address these challenges. Furthermore, through a case study conducted on a real-world vehicular dataset (i.e., Waymo Open Dataset), we demonstrate the promise of M3T FedFMs for vehicular networks and release our implementation to facilitate reproducibility and stimulate research in this emerging area (repository: https://github.com/KasraBorazjani/vehicular-fedfm)

Kasra Borazjani, Fardis Nadimi, Payam Abdisarabshali +5

Multimodal Federated LearningIntelligent Transportation SystemsMultimodal LearningFederated Learning
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Jun 4, 2026

GRAMformer: Any-Order Modality Interactions via Volumetric Multimodal Cross-Attention

Transformer-based multimodal models rely on attention mechanisms to integrate information across heterogeneous modalities. Despite their success, existing multimodal attention formulations compute their scores through collections of pairwise dot-product interactions or by concatenating all the modalities into the keys, even when multiple modalities should be jointly involved. As a consequence, current approaches either incur quadratic complexity in the number of modalities or fail to explicitly model interactions that depend on the joint configuration of multiple representations. In this work, we introduce the Volumetric Multimodal cross-Attention (VMA), a novel cross-attention mechanism in which attention scores are defined as a function of the joint geometry of a query and multiple modality-specific keys. VMA computes the volume spanned by query and key vectors across multiple modalities, capturing joint multimodal dependencies beyond pairwise similarity, enabling native modeling of any-order modality interactions. We integrate VMA into our novel multimodal transformer architecture, named GRAMformer, explicitly designed to integrate any number of modalities. We evaluate the proposed model on multimodal learning tasks, demonstrating improved effectiveness and efficiency.

Giordano Cicchetti, Eleonora Grassucci, Danilo Comminiello

Dept. of Information Engineering, Electronics, and Telecommunications, Sapienza University of Rome, Italy

Cross-AttentionMultimodal TransformerMultimodal FusionMultimodal LearningMultimodal Understanding
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Jun 3, 2026

Continual Visual and Verbal Learning Through a Child's Egocentric Input

Children learn the meanings of words from a continuous, temporally structured stream of egocentric experience. Recent work shows that neural networks can also learn word-referent mappings from a child's egocentric video recordings, but they cycle through the shuffled data for hundreds of epochs, contrasting with how children actually encounter their environment. We introduce BabyCL, a continual multimodal learning framework that processes the SAYCam dataset in a single chronological pass, combining streaming visual representation learning with an image-text contrastive objective. BabyCL combines a multi-stage temporal segmentation of the stream with a dual replay buffer that independently manages visual and multimodal histories, and it is jointly trained with three contrastive losses on a shared backbone. Under a matched optimization budget, BabyCL outperforms streaming learning baselines on the SAYCam Labeled-S 4AFC benchmark, substantially narrowing the gap to an upper bound of offline training. Ablations show that the gains are robust to the length of the online temporal segmentation window and the eviction rule of the replay buffer. Together, these results show that meaningful word-referent mappings can emerge under training conditions much closer to a child's actual experience.

Xiaoyang Jiang, Yanlai Yang, Kenneth A. Norman +2

Agentic Learning AI Lab, New York University · Department of Psychology, Princeton University

Egocentric Video UnderstandingReplay-Based Continual LearningMultimodal Contrastive LearningMultimodal Learning
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Jun 3, 2026

M3imic: Learning a Versatile Whole-Body Controller for Multimodal Motion Mimicking

Building a general-purpose whole-body controller is essential for enabling diverse motion capabilities in humanoid robots across a wide range of downstream tasks, including locomotion and loco-manipulation. Different tasks rely on distinct motion reference modalities: locomotion primarily depends on coordinated robot joint trajectories, whereas manipulation requires precise end-effector trajectory tracking. Existing methods often overlook the representational mismatch between dense robot joint angles and sparse end-effector poses. To address this, we propose Multi-Modal Mimic (M3imic), a versatile multi-modal whole-body control framework that unifies heterogeneous motion reference modalities, including robot joint angles, human pose trajectories, and end-effector poses, using modality-specific encoders to map them into a shared latent space. Leveraging large-scale reinforcement learning in the simulator, we train a single policy that achieves sim-to-real transfer across multiple motion reference modalities without modality-specific retraining. Extensive simulation and real-world experiments on the Unitree G1 robot are conducted to evaluate the proposed framework. In simulation, the policy achieves a peak success rate of 98.42% on an unseen test dataset, demonstrating its exceptional generalization capability. The code is available at https://github.com/Renforce-Dynamics/MultiModalWBC

Zuxing Lu, Ziang Zheng, Yao Lyu +7

School of Automation, Southeast University, Nanjing 210096, China · School of Vehicle and Mobility, Tsinghua University, Beijing 100084, China · Department of Robotics, Mohamed Bin Zayed University of Artificial Intelligence, Abu Dhabi 7909, UAE

RL for RoboticsHumanoid Robot ControlWhole-Body ControlRobot Imitation LearningMultimodal Learning
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Jun 3, 2026

Differentiable Efficient Operator Search

Efficient multimodal foundation models often rely on manually designed token-reduction operators, such as pruning, merging, pooling, and adaptive reweighting. Although these operators appear different, we show that they can be interpreted as distinct regimes of a shared operator space. Based on this view, we introduce Efficient Operator Search, a differentiable framework that jointly searches where to reduce tokens, how many tokens to retain, and how reduced token information should be processed. The proposed search space parameterizes layer activation, retention budget, and operator behavior, while the search policy optimizes task performance under one-sided budget and cost constraints. This formulation recovers representative hand-designed baselines as special cases and further discovers hybrid operators beyond isolated manual designs. Experiments on multimodal benchmarks show that the searched operators achieve competitive accuracy-efficiency trade-offs, especially under aggressive visual-token reduction. These results suggest that efficient multimodal inference can be reframed from manual operator design to differentiable operator search.

Xiaohuan Pei, Jiyuan Zhang, Yuanfan Guo +4

1The University of Sydney · 2ByteDance · 3Shanghai Jiao Tong University +1

Efficient Multimodal InferenceMultimodal Token CompressionMultimodal Foundation ModelsMultimodal Learning
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Jun 2, 2026

GridVQA-X: A Framework for Evaluating Multimodal Explainability Methods

With the increasing development of Vision-Language Models, it becomes imperative that their predictions are readily explainable to relevant stakeholders. However, the field of explainability has not kept pace with the multimodal surge. While recent Multimodal Explainable AI (MxAI) methods generate explanations to attribute the interaction between different modalities, current evaluation protocols lack the ground truth required to distinguish between true cross-modal reasoning (e.g., spatial composition) and shallow cross-modal shortcuts (e.g., Bag-of-Words attribute matching). It remains unknown whether MxAI methods faithfully capture synergistic interactions or merely hallucinate reasoning on models acting as simple feature detectors. In this paper, we introduce GridVQA-X, the first diagnostic framework specifically designed to evaluate cross-modal explainability. Unlike natural datasets, GridVQA-X leverages a closed-world synthesis logic to generate unique, mathematically guaranteed explanations. We utilize this controlled environment to train paired ground-truth models on identical architectures: MpureM_{\text{pure}}, which learns robust spatial-relational reasoning and MspurM_{\text{spur}}, which is structurally forced to rely on cross-modal shortcuts. This behavioral divergence creates a rigorous testbed: a faithful explainer must report distinct reasoning pathways for each model. Our findings reveal that widely used methods fail to distinguish between models relying on genuine spatial-relational reasoning and those exploiting cross-modal shortcuts, highlighting a critical gap in capturing true cross-modal synergy and misrepresenting how multimodal models actually make decisions.

Sujay Belsare, Sudarshan Nikhil, Sushant Kumar +2

1IIIT Hyderabad, India · University of Virginia, USA

Multimodal ReasoningMultimodal Model InterpretabilityExplainability EvaluationMultimodal Model EvaluationMultimodal LearningMultimodal Understanding
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Jun 2, 2026

A Benchmark for Semi-supervised Multi-modal Crowd Counting

This paper constructs the first benchmark on semi-supervised multi-modal crowd counting. To lay the foundation for this unexplored task, we first formulate the semi-supervised multi-modal setting and a standardized protocol that specifies the labeled-unlabeled data partition across different labeled ratios. Next, to establish solid reference points, we carefully tailor a diverse set of representative baselines, including existing fully supervised multi-modal methods and semi-supervised single-modal methods. Then, we carefully evaluate their performance under our proposed benchmark. Codes and the data partition will be released on https://github.com/HenryCilence/Semi-supervised-Multimodal-Crowd-Counting.

Haoliang Meng, Xiaopeng Hong, Yabin Wang +1

Harbin Institute of Technology · Pengcheng Laboratory

Crowd CountingSemi-Supervised LearningMultimodal Learning
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Jun 1, 2026

Multi-Modal Machine Learning for Breast Cancer Recurrence Prediction

Breast cancer recurrence, a leading cause of long-term mortality among survivors, requires timely and accurate risk assessment to guide follow-up care and treatment planning. Traditional predictive models, often limited to either structured or unstructured data alone, struggle to capture the full clinical context. This study examines the impact of integrating multi-modal clinical data, including treatment records, pathology reports, and clinician notes, on recurrence prediction. By integrating a rule-based regular expression extraction mechanism with a rigorous precedence-based conflict reconciliation strategy, our approach effectively recovers definitive tumor characteristics from free-text pathology narratives to augment structured records. We also benchmark performance against commonly used feature sets from prior breast cancer studies to assess the added value of multi-modal integration. Single-source and multi-modal inputs are evaluated across a range of machine learning models. Results show that multi-modal integration consistently improves predictive accuracy compared to single-modal methods.

Jiahao Shao, Xudong Wang, Anam Nawaz Khan +3

Department of Industrial & Systems Engineering, The University of Tennessee, Knoxville, TN 37996, USA · The University of Tennessee Medical Center, Knoxville, TN 37920, USA

Breast CancerClinical Outcome PredictionMultimodal Learning
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Jun 1, 2026

Towards Automated Discovery: A Review of Generative Models, Multimodal Learning and Closed-Loop Workflows in Inverse Materials Design

Inverse materials design is shifting materials discovery from forward prediction to targeted proposal of candidates that satisfy objectives under physical constraints. Here, we review recent advances in generative crystal structure modeling, multimodal learning, and closed-loop design pipelines for crystalline solids. We survey how modern generators learn chemical-structural priors from large databases to enable controllable sampling of periodic structures, and compare leading model classes including variational autoencoders, normalizing flows, autoregressive formulations, and diffusion models. Particular attention is given to how feasibility constraints and physical priors are enforced across the workflow, through representation choices, training objectives, sampling-time guidance, and post-generation screening and relaxation. We also discuss how multimodal learning fuses diverse materials modalities, including crystal structures, thermodynamic, electronic information, microscopy, spectroscopy, processing context, and scientific text, to construct a more universal, transferable representation of chemical space. In addition, diverse inverse-design strategies are examined, particularly those that integrate conditional generation with latent optimization, Bayesian optimization, reinforcement learning, and active learning. Finally, we highlight recurring failure modes, such as surrogate exploitation, diversity collapse, distribution shift, and the stability-synthesizability gap, and outline discovery-grade evaluation practices based on staged reporting of validity, novelty, uniqueness, stability, and cost.

Anand Babu, Rogério Almeida Gouvêa, Gian-Marco Rignanese

Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, Louvain-la-Neuve, Belgium. · WEL Research Institute, Avenue Pasteur 6, Wavre, Belgium.

Crystal Structure GenerationAutonomous Scientific DiscoveryConditional Generative ModelingInverse DesignMultimodal Learning
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Jun 1, 2026

When Meaning Travels: A Granular Lens on Hybrid-MoE's Role in Idiomatic Understanding for Language Models

In the contemporary epoch of multilingual education, learning idioms provides a fascinating gateway towards creativity, cultural values, historical context, and diverse perspectives inherent to various linguistic traditions. This paper showcases the navigation of retaining figurative and cultural semantics in low-resource Southeast Asian languages such as Hindi, Bengali, and Thai, where culturally rich idioms pose significant obstacles for computational modeling and cross-linguistic transfer due to their deep metaphorical complexity. To tackle such complexity, we present Varnika, a reconstructed multimodal idiom corpus comprising 3,533 multilingual idioms, enriched with seven idiomatic tones aligned with both textual and visual representations. Additionally, to infer informative idiomatic understanding, we introduce a Hybrid Mixture-of-Experts (HybridMoE) framework that embeds multiple idiomatic expert opinions while mitigating expert sparsity by integrating outputs from both selected and unselected experts through controlled hybridization, further augmented with Idiomatic Property Signals via masked multimodal embeddings. To analyze the performance across multiple dimensions, we propose the IDIO-TONE and Idiomatic Validation Score, a three-stage evaluation pipeline measuring (i) literal translation fidelity, (ii) visual-semantic alignment, and (iii) idiomatic meaning retention. Empirical evaluations highlight that HybridMoE achieves 5--6% performance gains across advanced vision language models, demonstrating improved representation of figurative language and culturally embedded meaning in multilingual multimodal settings

Sarmistha Das, Vaibhav Vishal, Shreyas Guha +3

Department of Computer Science and Engineering, Indian Institute of Technology Patna, India · School of Information Technology, King Mongkut’s Institute of Technology Ladkrabang, Thailand

Mixture-of-Experts Language ModelsLow-Resource Language ProcessingMultimodal Model EvaluationMultimodal Learning
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Jun 1, 2026

PaCX-MAE: Physiology-Augmented Chest X-Ray Masked Autoencoder

Clinical diagnosis often requires combining imaging with physiological measurements, yet deployed models typically operate on unimodal data. We present PaCX-MAE, a cross-modal distillation framework that injects physiological priors into chest X-ray (CXR) encoders while remaining strictly unimodal at inference. PaCX-MAE augments in-domain masked autoencoding with a dual contrastive-predictive objective, aligning CXR representations with paired ECG and laboratory embeddings. Extensive evaluation across nine benchmarks demonstrates consistent improvements over domain-specific MAE, particularly on physiology-dependent tasks (e.g., +2.7 AUROC on MedMod; +6.5 F1 on VinDr). The method proves highly label-efficient in the 1% regime and preserves anatomical fidelity, achieving parity with MAE on segmentation tasks. Zero-shot and attention analyses confirm that PaCX-MAE successfully learns to attend to physiological indicators, such as the cardiac silhouette, absent in standard visual pretraining.

Yancheng Liu, Kenichi Maeda, Manan Pancholy

Department of Computer Science, Brown University, Providence, RI, USA.

Cross-Modal Knowledge DistillationChest X-Ray ClassificationMasked AutoencodersMedical Image Representation LearningMultimodal Learning
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May 31, 2026

Beyond Captions: Context-Grounded Reconstruction for Biomedical Multimodal Continued Pretraining

Biomedical figures are explained not by captions alone but by body-text passages that discuss them. Yet current multimodal corpora typically reduce figures to isolated image-caption pairs, discarding this crucial context. Existing pipelines either omit this context or append it without enforcing the figure references that support each attachment, which can create unsupported image-text attachments and incoherent discourse. We introduce context-grounded reconstruction, a source-grounded framework that converts PubMed Central Open Access (PMC-OA) records into referentially coherent interleaved sequences. It recovers captions and source text, attaches context only through article-native figure references, repairs non-contiguous context, and prunes unsupported images. Starting from these reconstructed sequences, PMC-InterCPT first filters records for text quality and medical relevance, then applies evidence-aware allocation to form a 9.63B-token corpus for continued pretraining (CPT) of generative medical MLLMs. With fixed supervised fine-tuning (SFT), PMC-InterCPT improves Qwen3.5-4B-Base by 1.46 medical-average points and 3.11 general/scientific-average points over a token-matched raw source control, and surpasses a 42% larger raw-data run. Gains transfer to Qwen3.5-2B-Base and LLaVA-OneVision-1.5-4B-Base. Controlled ablations show that context-grounded reconstruction, rather than simply appending article context, is central to useful biomedical multimodal CPT.

Guanghao Zhu, Zeyu Liu, Zhitian Hou +10

The Hong Kong Polytechnic University · Sun Yat-sen University · PolyU-Daya Bay Technology and Innovation Research Institute

Vision-Language ModelsMultimodal PretrainingMedical VLMsContinued PretrainingMultimodal Learning
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May 31, 2026

Learning Multi-Modal Trajectory Policies for Data-Efficient Robotic Manipulation

Robotic manipulation requires the effective integration of heterogeneous inputs, including visual observations, language instructions, and trajectory representations, to generate accurate actions. Existing transformer-based policies typically process these heterogeneous modalities within a shared parameter space, which often leads to modality interference and inefficient representation learning, especially in data-scarce scenarios. While Mixture-of-Experts (MoE) offers a scalable solution through expert specialization, conventional routing mechanisms are often sensitive to such cross-modal representation discrepancies, resulting in unstable expert assignment and expert collapse. In this work, we propose MATE (Multi-ModAl TrajEctory Policies), a novel trajectory prediction framework built upon MoE. Specifically, we introduce a Multi-Modal MoE architecture to achieve fine-grained sub-token feature decoupling, and design a cross-modal cosine router for stable and scale-invariant expert assignment across heterogeneous modalities. We further employ temperature-controlled routing and stochastic noise injection to improve expert balance and prevent premature routing collapse under scarce demonstrations. Experiments on the LIBERO benchmark show that our MATE consistently outperforms prior work under data scarcity. It achieves a 4.75% improvement in average success rate over the trajectory-guided counterpart. Real-world experiments on robotic ping-pong also suggest that the predicted trajectories can provide useful guidance for downstream robotic execution, further indicating the practical feasibility of our algorithm.

Zijia Chen, Yuenan Hou, Xinhua Jiang +3

College of Electronic Science and Technology, National University of Defense Technology Changsha, 410073, China · Shanghai AI Laboratory Shanghai, 200000, China

Robot Policy LearningMixture of ExpertsRobotic ManipulationData-Efficient Robot LearningMultimodal Trajectory PredictionMultimodal Learning+1
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May 30, 2026

Response-Aware Multimodal Learning for Post-Treatment Visual Acuity Forecasting

Long-term visual acuity (VA) outcomes after anti-VEGF therapy are central to patient counseling, expectation setting, and follow-up planning in diabetic macular edema (DME). However, in clinical practice, physicians must often estimate long-term visual trajectories based only on early post-treatment findings, making reliable prognostication difficult. Although prior OCT-based learning approaches have largely focused on short-term response or single-endpoint prediction, modeling VA trajectories across multiple future time points from early longitudinal observations remains insufficiently explored. In this study, we assembled a real-world cohort of 188 anti-VEGF--treated DME patients with paired baseline and month-1 OCT scans, along with tabular OCT-derived biomarkers and non-imaging clinical variables. Using only these early data, we formulate a multi-horizon VA forecasting problem aimed at predicting visual outcomes at 3, 6, 12, 18, and 24 months, reflecting clinically meaningful follow-up intervals. We propose ReVA, a response-aware multimodal framework that integrates structural features from baseline and month-1 OCT with the tabular variables to capture baseline disease status and early treatment response. ReVA uses spatial attention to preserve localized prognostic imaging features and a dependency-aware tabular encoder to model interactions among clinical variables. These multimodal representations are fused to predict patient-specific long-term visual acuity trajectories. The proposed framework achieves MAE =0.1246=0.1246, RMSE =0.1621=0.1621, and R2=0.6064R^2=0.6064 for 24-month VA prediction, with consistent performance across all forecast horizons. Our findings show that incorporating early treatment-response signals enables clinically meaningful long-term visual acuity forecasting, supporting data-driven decision support for routine anti-VEGF management.

Phuoc-Nguyen Bui, Van-Vi Vo, Duc-Tai Le +5

Research Convergence Institute, Sungkyunkwan University, Korea · Dept. of AI Systems Engineering, Sungkyunkwan University, Korea · College of Computing and Informatics, Sungkyunkwan University, Korea +2

Long-Term Time Series ForecastingClinical Outcome PredictionMultimodal LearningOphthalmology
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May 30, 2026

V-LynX: Token Interface Alignment for Video+X LLMs

This study introduces an intriguing phenomenon in Video LLMs: rather than merely translating frames into textual embeddings, Video LLMs establish a continuous manifold, token interface, allowing visual tokens to operate as standalone entities within the architecture. Exploiting this discovery, we propose V-LynX, a scalable framework that integrates novel modalities into Video LLMs by repurposing the internalized interface. Departing from conventional paradigms that necessitate heavy modality-specific encoders or paired supervision, V-LynX employs a lightweight auxiliary pathway in parallel with the frozen vision encoder. Our method integrates new sensory inputs with intrinsic video priors by aligning both attention responses and statistical distributions using unpaired unimodal data sets. This ensures manifold compatibility while preserving the integrity of the Video LLMs. Extensive benchmarks demonstrate that V-LynX achieves SOTA and efficiency across audio-visual QA, 3D reasoning, high-frame-rate, and multi-view video understanding. The code is available at https://github.com/park-jungin/lynx.

Jungin Park, Jiyoung Lee, Kwanghoon Sohn

Yonsei University, Seoul, South Korea · Ewha Womans University, Seoul, South Korea

Cross-Modal AlignmentMultimodal QAVideo-Language ModelsAudio-Visual QAMultimodal Learning
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May 28, 2026

Your Multimodal Speech Model Says I Have a Face for Radio

As large neural models have become better at language tasks, researchers are increasingly building multi- and omnimodal models that handle more modalities of data. One example is the expansion of speech recognition models to audio-visual data for noise mitigation and multimodal subtitling. While performance and bias have been studied extensively in the single-modality regime, it is unknown how new modalities affect this, even though they produce biases in humans. We therefore propose the first bias evaluation of multimodal speech recognition, where we create videos pairing different faces with the same audio, and measure changes in speech transcription accuracy. We find large quality-of-service differences across mWhisper-Flamingo and Gemini models, with drops of up to 4.05 word error rate points, across self-declared gender, ethnicity, and their intersection. Our findings point to a priority for developers to evaluate, fix, and communicate such limitations, as providing more signals through additional modalities is not necessarily better, and may even lead to biased outcomes.

Maya K. Nachesa, Vlad Niculae, Vagrant Gautam

Language Technology Lab University of Amsterdam · Heidelberg Institute for Theoretical Studies

ASR EvaluationDemographic Bias in ASRAutomatic Speech RecognitionAudio-Visual Speech RecognitionMultimodal Foundation ModelsMultimodal Model Evaluation+2
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May 28, 2026

OVA-IB: One vs All Information Bottleneck for Multi-Modal Alignment

Contrastive learning is effective for aligning paired views or modalities, but alignment beyond two modalities remains non-trivial and comparatively underexplored. Pairwise CLIP-style losses decompose multi-modal alignment into independent two-way comparisons and therefore do not explicitly model higher-order dependencies among multiple modalities. Recent beyond-pairwise objectives approach this problem from statistical or geometric perspectives, but arbitrary-modality alignment still lacks a principled criterion for defining what each modality should preserve and compress relative to the others. We revisit arbitrary-modality alignment through the Information Bottleneck principle. In multi-modal learning, sufficiency should preserve information predictable from the remaining modalities, while minimality should compress modality-specific information not supported by them. This naturally leads to a One-vs-All view, where each modality is characterized with respect to the remaining modalities. We propose OVA-IB, an Information Bottleneck framework for arbitrary-modality alignment. OVA-IB optimizes a tractable One-vs-All contrastive lower bound for sufficiency connected to a Dual Total Correlation-style objective, uses a parameter-free geometry-aware projection score, and derives a tractable upper-bound regularizer for minimality by bounding each representation's dependence on its own input with representation distributions induced by the remaining modalities. Experiments on classification, regression, modality-agnostic evaluation, and cross-modal retrieval benchmarks demonstrate strong and robust performance.

Tianchao Li, Shujian Yu, Xinrui Zu +4

Hong Kong University of Science and Technology, Hong Kong · Vrije Universiteit Amsterdam, Netherlands · UiT – The Arctic University of Norway, Norway +3

Cross-Modal LearningCross-Modal AlignmentInformation BottleneckMultimodal Contrastive LearningMultimodal LearningMultimodal Understanding
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May 28, 2026

MIRAGE: Adaptive Multimodal Gating for Whole-Brain fMRI Encoding

Recent progress in task-optimized neural networks has established encoding models as a powerful tool for predicting brain responses to naturalistic stimuli, yet most existing approaches rely on unimodal representations. The emergence of omni-modal foundation models and rich multimodal neural datasets enables encoding models that jointly integrate visual, auditory, and linguistic information across subjects. We introduce MIRAGE, a brain encoding framework for predicting whole-brain fMRI responses to naturalistic audiovisual stimuli. MIRAGE achieves state-of-the-art performance via a native multimodal backbone and adaptive feature gating across layers. These representations are then combined with a transformer-based brain encoder and a subject-specific linear head over the cortical parcels. Controlled comparisons show that natively multimodal features consistently outperform post-hoc aggregation of independent unimodal features, across architectural levels and backbones. Beyond predictive accuracy, the learned attention weights are directly inspectable to interpret the modality-specific gating profile over the backbone, and each modality traces a distinct anatomical pattern across cortex. Together, these results propose adaptive layer-wise aggregation of natively multimodal features as a generalizable, interpretable, and accurate approach for whole-brain encoding.

Abdulkadir Gokce, Badr AlKhamissi, Martin Schrimpf

NeuroAI Lab, EPFL

NeuroimagingNeural EncodingMultimodal FusionMultimodal LearningMultimodal UnderstandingGated Multimodal Fusion
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