Receiver Operating Characteristic Area Under The Curve
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11 papers in the last four weeks, up 120% on the four weeks before. 0.1% of all new papers.
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Video anomaly detection (VAD) is an actively studied task, having wide applications in typical scenarios such as public surveillance and road traffic safety. The task is also relevant for robotic arm interactions, where it has several downstream applications, including learning better interaction and manipulation abilities, triggering recovery procedures when anomalies occur, etc. Despite its relevance, the exploration of anomaly detection in robotic arm manipulation videos is limited by the low number of available resources. To this end, we introduce RoboVAD, a large-scale benchmark for video anomaly detection that comprises challenging cross-domain evaluation scenarios, where certain actions (tasks executed by a robotic arm) and anomaly types (mistakes that occur while performing certain tasks) remain unseen during training. RoboVAD is designed to benchmark VAD methods in realistic scenarios, where robotic arms can perform unforeseen tasks, and thereby encounter new anomaly types. We train and evaluate several state-of-the-art VAD methods, including a novel method specifically adapted for robotic arm manipulation. While the proposed method outperforms many state-of-the-art competitors, all methods remain below a micro-averaged frame-level AUC threshold of 70% in the most challenging evaluation setup, confirming the difficulty of the proposed benchmark. We publicly release our dataset and code at https://zenodo.org/records/22754659.
A multimodal large language model for evidence-based autism spectrum disorder screening
The clinical management of autism spectrum disorder (ASD) faces a bottleneck in early screening, mainly because trained specialists are scarce and conventional assessment tools are subjective. Here, we introduce ASDchat, a multimodal large language model designed for evidence-based ASD screening, which takes video, audio, and dialogue as input. ASDchat adopts a dual-branch architecture, where the decision branch generates screening probabilities and the evidence branch generates traceable, timestamped behavioral evidence aligned with standardized clinical criteria (ADOS-2). The model was trained and evaluated on a dataset of 1,035 participants from 27 sites in China, which covered typically developing (TD) children, children with ASD, and children with other disorders. For ASD versus TD, ASDchat reached an area under the receiver operating characteristic curve (AUC) of 0.953 0.021. On 9 held-out sites that were not used for training, the mean AUC was 0.932. Furthermore, unsupervised clustering of the behavioral dimensions split the ASD cases into six subtypes with different phenotypic profiles, and ASDchat suggests an intervention for each subtype. ASDchat provides a feasible path for large-scale, evidence-based early ASD screening in clinical practice.
AUC Maximization from Biased Positive-unlabeled Data with Confidence
Maximizing the area under the receiver operating characteristic curve (AUC) is a standard approach to imbalanced binary classification. Although positive and negative data are required for maximizing the AUC, negative data are often difficult to collect in some real-world applications due to privacy concerns or the need for specialized expertise to annotate them. Thus, AUC maximization from positive and unlabeled (PU) data has been attracting attention. Existing methods assume that labeled positive data are unbiased samples from the true positive distribution. However, this ideal assumption is often violated in practice. In this paper, we propose a method to maximize the AUC from biased PU data. To address the bias, our key idea is to exploit {\it confidence}, i.e., the probability that an instance is positive, associated with the small number of labeled positive data. We derive an estimator of the AUC risk using biased PU data with confidence, enabling AUC maximization under such bias. We further show that the rewritten AUC risk induces a Bayes-optimal AUC ranking even when the available confidence is any strictly increasing transformation of the true posterior probability. We experimentally show the effectiveness of our method on eight real-world datasets.
LAION-Mobile: Evaluating Deepfake Detectors On One Million Smartphone Photos
Most Deepfake detectors report near-perfect AUC scores on their reference benchmarks. However, a recent ICML position paper argues that these evaluations collectively neglect the impact of modern smartphone photography: the widely used on-device neural image-signal processing pipelines (like multi-sensor fusion or noise and motion-blur suppression) increasingly shift the imaging paradigm from simple lens projections towards computational photography. Hence, devices actually generate, rather than record photos. This increases the risk that deepfake detectors may flag ordinary phone photos as fake. Due to the lack of large-scale datasets containing images from modern smartphones, this hypothesis has so far only been tested in small proof-of-concept studies. The aim of this paper is to close this gap. We introduce LAION-Mobile, an open dataset containing about 1 million smartphone images with EXIF metadata distilled from re-LAION-5B. Evaluating twelve state-of-the-art deepfake detectors with their original paper checkpoints on a 9,115-image evaluation sample of this pool (DIRE on 738), we report three key findings: (i) On modern AI content no detector exceeds AUC 0.624, and five of twelve fall below chance. (ii) Real-photo false-alarm rates are an artefact of threshold calibration: thresholds fitted on legacy GAN data make several detectors look deployable (less than 11 percent FPR), yet the same detectors flag 17-91 percent of real photos once the identical criterion is refit on modern content. (iii) Consequently, no detector both beats chance on modern AI content and keeps a deployable real-photo false-alarm rate. Mirroring the device mix of web collections, the corpus probes the first neural-ISP generation (2018-2020); current flagships are essentially absent, leaving the modern-ISP regime as the open gap.
Safe to Stop? Risk-Constrained Stopping for Sequential Clinical Diagnosis Agents
Clinical diagnosis agents must decide not only what test to request next, but also when to diagnose or defer. Existing agent benchmarks largely evaluate accuracy after fixed or unconstrained interaction, leaving autonomous stopping reliability implicit. We present Cros, a risk-constrained stopping layer combining state-wise error ranking, policy design on disjoint development splits, and LTT-style exact tests of selective diagnostic error and minimum autonomous coverage for complete sequential policies. Its finite-sample guarantee requires the candidate family, testing rule, and any randomization to be frozen before calibration labels are accessed. On a 1,834-episode MIMIC-derived abdominal-pain benchmark, the full ranker achieves exploratory state-error AUROC 0.853, compared with 0.715 for maximum class probability and 0.552 for the backbone's native stop score. On the previously viewed 367-episode evaluation split, analytically averaging over the frozen Cros weights yields 16.9% selective error at 78.8% coverage, cost 5.57, and 0.68 tests, versus 30.8% error at 100% coverage, cost 8.14, and 1.53 tests under native stopping. Forced continuation is non-monotone: error is 28.3% with HPI alone and 34.3% after full workup. However, the uniform-weight mixture ablation is cheaper on this viewed split despite missing the locked development margins, and Cros nominally satisfies the joint criterion in only 6 of 20 development resplits. Because evaluation labels were inspected during earlier development, these findings provide exploratory feasibility and audit evidence, not a confirmatory safety certificate.
Parser-Free VLM Verification for Federated Weakly Supervised Video Anomaly Detection
How can vision-language models help video anomaly detection (VAD) when surveillance data remain distributed, weakly labeled, and resource-constrained? Most weakly supervised VAD methods assume centralized training; recent VLM-based extensions further rely on dense inference, generated explanations, or additional adaptation. We introduce a lightweight federated MIL-VLM cascade in which only a compact MIL scorer is trained across clients, while a frozen VLM verifies high-scoring suspect segments post hoc. We study two VLM feedback interfaces: parsed text-generation decisions and a logit-based interface that extracts a continuous anomaly score from next-token Yes/No probabilities. Experiments on UCF-Crime with InternVL3.5-2B and Qwen3-VL-2B-Instruct show that text-generation verification can improve frame-level AUC after diagnostic temporal post-processing, but remains sensitive to prompts, parsers, model choice, and smoothing. In contrast, the logit interface provides a fixed parser-free signal that improves both frame-level AUC and frame-level AP over the MIL baseline across both VLMs, without temporal post-processing in its main configuration. Since suspect segments are updated independently once available, next-token logit feedback provides a simple segment-local alternative to text-generation verification.
Hearing the Whispers: Black-Box Membership Inference Attacks on Finetuned TTS Models
Text-to-Speech (TTS) foundation models are increasingly fine-tuned on private datasets to synthesize highly personalized voices, introducing severe privacy risks by exposing both biometric identities and sensitive speech content. Existing black-box membership inference attacks (MIAs) follow a two-stage pipeline of query generation and representation engineering, both of which face unique challenges when adapted to TTS. For query generation, dual conditioning on synthesis text and reference speech creates a large and underexplored query design space with no established criterion for identifying an effective query. For representation engineering, the multi-level speech characteristics and temporal variability of speech make low-level representations and direct comparisons inadequate for capturing membership signals. To address these challenges, we present the first black-box MIA framework explicitly tailored to TTS models at both the speaker and record levels. For query generation, we characterize the feasible query space and establish two criteria, scorable extent and memorization elicitation, for evaluating five representative queries, identifying recitation as the strongest. For representation engineering, we obtain multi-level speech representations from embedding models and temporally align the generated and target audio for fine-grained comparison. Evaluations across three state-of-the-art TTS models (CosyVoice2, F5-TTS, and XTTS-v2) fine-tuned on two benchmark datasets (VCTK and British Dialect) reveal severe privacy leakage: speaker-level AUC remains above 0.80 and approaches 1.0 in the strongest settings, while record-level AUC ranges from 0.80 to 0.90 and remains effective even in challenging scenarios where both members and non-members are of the same speakers. We further identify speech characteristics associated with disproportionate vulnerability to memorization.
Real-Time Video Anomaly Detection Using YOLO Pose Estimation and CLIP-Based Semantic Scoring
We propose a lightweight two-stage framework for real-time video anomaly detection. The first stage employs YOLO v11n-pose to detect persons and extract seventeen skeletal keypoints in a single forward pass. The second stage encodes each cropped person region through CLIP ViT-B/32 and computes cosine similarity against predefined textual descriptions of anomalous behaviors. This architecture eliminates the need for optical flow, standalone pose estimators, and density-based scoring modules. Experiments on CUHK Avenue, ShanghaiTech Campus, and a custom indoor dataset collected at Chulalongkorn University demonstrate an end-to-end throughput of approximately 51 FPS on an NVIDIA Titan XP GPU, a 3.36x speedup over the multi-feature baseline, while maintaining frame-level AUROC values of 89.26%, 70.26%, and 84.13%, respectively.
Federated Multi-Task Learning for Bladder Tumor Segmentation and MIBC Classification Using a Hybrid CNN-Transformer Architecture
Accurate bladder tumor segmentation and assessment of mus- cle invasion from T2-weighted MRI are important for treatment plan- ning, but developing robust models across institutions is challenging be- cause patient data cannot be centrally pooled and imaging characteristics vary across scanners and acquisition protocols. We propose a federated multi-task learning framework for joint bladder tumor segmentation and MIBC/NMIBC classification across four clinical centers. The proposed Swin Hybrid model combines a ResNet-34 branch for local texture and boundary information with a Swin-Tiny Transformer for global anatomi- cal context. A segmentation-guided classification mechanism further uses tumor localization information to support MIBC prediction. We also investigate several augmentation strategies under both centralized and federated training to improve robustness to multi-center variability. Ex- periments on the FedBCa dataset show that the Swin Hybrid provides the best overall balance between segmentation and classification among the evaluated architectures. Under federated training, Geo+Elastic aug- mentation achieved a DSC of 0.8100 and a patient-level AUC of 0.8931, yielding the highest combined score of 0.8474. These results demonstrate that joint segmentation and classification can be effectively performed across multiple institutions using federated training without centralizing patient data.
Self-Supervised Pretext Tasks for Infant Cry Analysis: A Controlled Comparison and a Cautionary Result on Donateacry
We compare six self-supervised pretext tasks for infant cry analysis under a fixed budget, meaning the same compact encoder of 1.17M parameters, the same 115 hours of license-verified public pretraining audio, and the same evaluation protocol for every candidate. On cry detection the reconstructive objectives dominate, and a linear probe over a masked-spectrogram encoder reaches 0.988 AUC with subject-wise splits even though the encoder never observed a cry during pretraining. On cry-reason classification over donateacry, the de facto public benchmark for cry reasons, every encoder performs at chance (0.38 to 0.54 macro AUC over 5 classes), and neither domain adaptation on 1.8 hours of real cries nor end-to-end fine-tuning moves the result. Since a frozen HuBERT-base with 80 times more parameters shows the same pattern, the bottleneck must sit in the labels and not in model capacity. We then reproduce the 90%+ accuracies of the donateacry literature on our own system by changing nothing but the evaluation protocol: clip-wise splits raise accuracy to 85.2% (barely above the 83.8% majority-class baseline), and applying augmentation before splitting raises it to 97.9%, matching the reported state of the art, from the same model that measures 0.49 macro AUC under subject-wise splits. Under leakage-free splits, a twentyfold augmentation of the labeled set (vocoder speaker perturbation and noise mixing, 21 hours) leaves cross-subject AUC unchanged: for this task the effective sample size is the number of infants. We release code, seeds and per-clip license manifests.
PRIME: Mitigating Subgroup Optimization Competition in Shared CTR Top Networks with Plug-in Residual Input-Conditioned Mixture of Expert
Click-through rate (CTR) models vary in feature-interaction design, yet their top networks usually remain a single multilayer perceptron shared by all examples. Heterogeneous user, item, and context subgroups therefore update the same parameters; weakly aligned learning signals make the aggregate gradient a compromise among competing directions. We study the competition on Avazu with 4 models and 4 semantic fields. Across all architectures, semantic subgroups show lower Top-NN gradient cosine similarity than random groups matched by sample size and label ratio, with reductions of 0.23-0.37. This competition motivates input-conditioned experts, but directly replacing an established Dense mapping changes its initial function, sharing pattern, and capacity, obscuring the source of gains. We introduce PRIME (Plug-in Residual Input-conditioned Mixture of Experts), a Dense-anchored mixture of low-rank residual experts. PRIME anchors the original prediction and uses zero-residual initialization to match the Dense baseline exactly at training onset. Input-dependent routing weights low-rank experts for example-specific logit corrections; multi-bag aggregation and EMA load biases stabilize conditional estimation. We evaluate PRIME on held-out Avazu and Criteo test sets across 13 CTR architectures and five paired seeds. Median paired AUC gains are +0.0022 and +0.0066, with LogLoss reductions of 0.0011 and 0.0081, respectively. On FiBiNET and DCNv2, PRIME outperforms APG in all ten seed-level AUC comparisons while using fewer parameters and lower inference latency on both backbones. These results show that function-preserving conditional residuals add input-dependent capacity while preserving the Dense path and its optimization stability. Code is available at https://github.com/YH-learning/PRIME.
CoMedBench: A Multi-Source Benchmark of Synthetic Medical Data Fidelity and Downstream Utility
Access to clinical data is essential for developing reliable healthcare machine learning systems, but direct use of electronic health records is constrained by privacy regulation, institutional review, data-use agreements, and the risk of re-identification. Synthetic data promises a practical alternative: it can preserve useful statistical and clinical structure while reducing exposure of sensitive patient records. Prior studies often evaluate a single generator, one dataset, or a narrow downstream task, making it difficult to know when synthetic data can support model development and when it fails to preserve task-critical signal. We introduce CoMedBench, a reproducible benchmark that evaluates a family of generators under a common clinical-validity framework and one shared training and evaluation engine, spanning static tabular and temporal downstream tasks on established critical-care datasets. In total the benchmark spans 37 dataset-task pairs across two modalities consists of 20 static tabular and 17 temporal ICU time-series-drawn from seven public data sources: three intensive-care databases (MIMIC-III, MIMIC-IV, and eICU) together with the UCI Machine Learning Repository, the CDC BRFSS diabetes cohort (2015), NHANES (1999-2014), and the pycox survival datasets (GBSG and METABRIC). The benchmark evaluates both statistical fidelity and task utility by comparing models trained and tested across real and synthetic data. In these settings, synthetic training data preserves most of the downstream signal: on tabular tasks the reference generator CoMed-CTGAN retains a mean AUROC utility (the synthetic-to-real performance ratio) of 90.6%, rising to 97.3% for the strongest generator, CoMed-TVAE. Temporal ICU tasks are harder and more generator-sensitive: CoMed-CTGAN retains 81.6% (AUROC) and only 64.0% under the imbalance-sensitive AUPRC, whereas CoMed-TVAE still retains ~95% (AUROC).
Chartography: A Benchmark for Professional Chart Understanding
Professionals across medicine, engineering, finance, manufacturing, and the sciences often make consequential decisions from charts. Existing chart benchmarks do not sufficiently measure this ability: they are dominated by bar, line, and pie formats, rely on shorter reasoning chains, and are nearing saturation, with frontier models already scoring 80-90%. We introduce Chartography, a benchmark of 100 tasks that pair charts drawn from professional practice, in domain-specific formats that standard chart benchmarks rarely include, with questions written by professionals who read these charts for a living and independently verified by three additional experts. In an evaluation of 30 frontier-model configurations (20 scored trials per task), the best configuration reaches only 45.0% mean pass@1; the remainder span 9.0-39.5%. Failures concentrate in visual perception: models can miss nuanced features, misread values along sparsely labeled axes, mishandle projected 3D geometry, and violate domain conventions encoded in the chart. We release all tasks, images, provenance metadata, and evaluation code.
Measuring the Wrong Thing: Internal Harmfulness Scores Anti-Rank Successful Jailbreaks
Internal safety scores judge a prompt before any text is generated, and they are validated by how well they separate harmful prompts from benign ones. That separation is then read as evidence that the score will also catch the attacks that succeed. Harmful intent is a property of the prompt. Jailbreak success is an outcome produced later by a particular target model, decoding policy, and judge. A filter tuned on a score that measures the wrong quantity spends its false positive budget on attacks that would have failed anyway. In this paper we audit that inference. Attention based measurements are usually read from prompt dependent locations, so a wrapper changes both the content being judged and the place the signal is taken from. We therefore introduce Active Attention Probing, which supplies a fixed content independent measurement coordinate. We pair every base goal with a plain and a wrapped version and generate real completions from the target models. On Llama, wrapping raises harmful generation from 0.05 to 0.27 while harmful intent AUROC falls from 0.936 to 0.803, so the attacks grow more dangerous while the prompts look safer to the score. Among wrapped harmful prompts the outcome AUROC is 0.220, which places the attacks that succeeded below the attacks that failed. Rare token, passive, and detector derived channels reproduce the reversal on the same matched design, and the reversal itself persists across three target models, seven attack families, and two independent judges. Distribution shift then degrades calibration and threshold transfer before it degrades ranking.
Hit Selection Using SSMD-Based Machine Learning Performance Metrics in High-Throughput Screening Assays
High-throughput screening (HTS) assays are central to early-stage drug discovery but are often limited by extreme data sparsity, as primary screens typically use only a single replicate per test substance. This sparsity makes conventional machine-learning performance metrics, such as sensitivity, specificity, and area under the receiver operating characteristic curve (AUROC), difficult to estimate empirically because they require adequately sized labeled samples. Here, we introduce a model-based framework that derives these classification metrics from the strictly standardized mean difference (SSMD), a well-established HTS effect-size parameter. Under a Gaussian equal-variance assumption, we derive closed-form relationships linking SSMD to Youden-optimal sensitivity and specificity, and sensitivity at a preset specificity, yielding explicit estimators and exact confidence intervals from the noncentral t-distribution, even under single-replicate designs. Unlike classical statistical power, which approaches 1 as sample size grows regardless of how small the true non-zero difference between group means is, the SSMD-derived sensitivity converges to a finite population value that reflects the true degree of separation between two groups, making it a more meaningful and stable performance measure for hit selection. We demonstrate the utility of this framework in a hepatitis C virus primary siRNA screen comprising approximately 22,000 single-replicate measurements, showing that SSMD, AUROC, and sensitivity-based thresholds yield equivalent and interpretable hit sets. This work bridges classical HTS statistics and machine-learning evaluation theory, providing a statistically principled, reproducible way to estimate classification performance in ultra-low-replication screening workflows.
Comparing SGLD and a fixed-noise Predictor-Corrector adaptation in canonical Joint Energy-Based Models on CIFAR-10
Joint Energy-Based Models (JEM) unify classification and generation within a single network and support out-of-distribution (OOD) detection. Canonical JEM training relies on stochastic gradient Langevin dynamics (SGLD); a theoretically motivated alternative, the Predictor-Corrector (PC) sampler, has not previously undergone a systematic replication test on the canonical model. We reproduce canonical JEM on WideResNet-28-10 without normalisation layers on two independent runs and test a fixed-noise PC adaptation - with the degenerate annealed-noise predictor replaced by a deterministic gradient step - across three protocols: the adapted sampler replacing SGLD throughout the full training trajectories (115-132 epochs); cold-start generation (FID); and refinement-style multi-OOD detection (AUROC). The reconstruction reaches 92.88% test accuracy and buffer-FID 44.46 (canonical: 92.9% and 38.40). We document two failure modes: catastrophic late-training divergence with the signature of the canonical outlier-buffer mechanism (all four runs), and run-dependent SVHN OOD-discrimination dynamics. No consistent method-level advantage of the adaptation over SGLD is observed on any protocol: refinement AUROC differences stay below 0.007 across ten checkpoint-OOD pairs; seeded cold-start generation favours SGLD by about five FID points; on the training protocol a hierarchical seed-by-image bootstrap gives a 95% confidence interval on the macro-averaged AUROC difference that contains zero, while a seed-level equivalence test with two runs per method cannot establish formal equivalence. The training-protocol data are consistent both with equivalence and with a small directional effect. This outcome is consistent with theory: the guarantees of the annealed-noise PC framework do not transfer to the constant-noise regime of canonical JEM.
Latent Stability Analysis of Malware Representations Under Feature-Space Perturbations
Static malware detectors are commonly evaluated using clean-sample metrics such as accuracy, F1, ROC AUC, and PR AUC. However, these metrics provide limited insight into how learned malware representations behave when feature vectors are perturbed, how close samples move toward uncertain decision regions, or whether compressed representations preserve security-relevant structure. This paper presents a latent-stability analysis pipeline for malware perturbation assessment in EMBER feature space. The pipeline compares full EMBER features, PCA-based compression, beta/denoising variational autoencoder representations, Mandelbrot-inspired escape-time descriptors, and a PINN-style latent-flow module. We define Latent Escape Divergence (LED) to measure changes in escape-time profiles under perturbation, and use PINNFlow-derived residual, velocity, risk, and gradient-shift metrics to characterize latent movement. Experiments are conducted on EMBER static PE feature vectors using 180,000 training samples, 180,000 test samples, and 240,000 holdout samples. Full EMBER features achieve the strongest clean classification performance with ROC AUC of 0.9962 and F1 of 0.9713, while PCA-64 is the strongest compressed baseline with ROC AUC of 0.9846 and F1 of 0.9347. The proposed VAE+Mandelbrot+PINNFlow representation does not outperform these baselines for clean classification, but it provides additional diagnostic value under controlled feature-space perturbation probes.
Harmonized Interpretable ECG Waveform Features for Robust Cross-Dataset Clinical Prediction
Electrocardiograms (ECGs) are widely used for cardiovascular risk prediction, yet models often fail to transfer across hospitals because of protocol, population, and measurement differences. We benchmark cross-dataset generalization on three tasks - heart failure classification, 30-day all-cause mortality, and 30-day mortality among sinus-rhythm ECGs - using two large cohorts (MIMIC-IV and the Alberta Cohort). To reduce vendor-specific measurement mismatch, we build a harmonized, interpretable feature representation computed directly from raw waveforms: FeatureDB morphology/heart-rate-variability summaries plus compact time-frequency descriptors (autoregressive and wavelet features). We train XGBoost models on this unified feature space and evaluate with patient-disjoint internal and bidirectional external testing. We pre-specify two hypotheses: (H1) external AUROC retains at least 90% of source-site internal AUROC under transfer, and (H2) internal AUROC of the harmonized feature set stays within 10% of dataset-native machine-measurement models. Across tasks, internal AUROC is 0.79-0.82 and cross-dataset AUROC is 0.74-0.78, with larger and direction-dependent AUPRC shifts under transfer. As an exploratory benchmark, an end-to-end ConvNeXt model trained directly on raw ECG waveforms with age and sex achieves higher internal AUROC, while the harmonized representation remains competitive in relative cross-dataset transfer stability. These findings show that a consistent waveform-derived feature interface preserves performance, supports realistic external validation, and provides a transparent alternative for cross-site clinical prediction.
Metamorphic Testing for Clinical ML Models: A Framework Proposal and Pilot Study
Machine learning models for clinical prediction tasks, such as in-hospital mortality and sepsis onset, routinely achieve high AUROC scores. However, AUROC measures ranking performance rather than clinical sensibility. A model may rank patients correctly overall while predicting a lower mortality risk when a patient's SOFA score worsens, contradicting established medical knowledge. This paper proposes applying metamorphic testing (MT) to clinical machine learning models to evaluate behavioral correctness without requiring ground-truth labels for individual predictions. We design a catalog of 12 candidate metamorphic relations (MRs) for three ICU prediction tasks using the MIMIC-III and MIMIC-IV datasets, with each MR grounded in an authoritative clinical guideline. We further propose a five-layer validation strategy to ensure that MRs are clinically sound before deployment. As a feasibility study, we evaluate the approach on the UCI Heart Disease dataset. Although the three clinical models achieve strong predictive performance (AUROC = 0.849-0.900), they exhibit MT violation rates ranging from 27% to 87% across five pilot MRs. An injected-fault experiment further shows that a sign-negation error in a blood pressure feature remains undetected by AUROC but increases the MT violation rate by 31-67 percentage points. These findings suggest that metamorphic testing provides a valuable complement to conventional performance metrics for assessing the behavioral correctness of clinical prediction models.
Spatially Grounded Concept Bottleneck Models for Trustworthy Breast Ultrasound Diagnosis
Concept Bottleneck Models provide interpretable-by-design predictions by mediating diagnosis through human-understandable concepts, but in medical imaging, their trustworthiness is often limited by the quality and granularity of available supervision. In particular, predicted concept activations can be driven by irrelevant regions, leading to spatially unfaithful explanations. We study a data-centric spatially grounded Concept Bottleneck Model (SG-CBM) that leverages coarse lesion delineations as weak supervision to encourage anatomically plausible concept evidence. For breast ultrasound, we derive two clinically motivated zones from each lesion mask: (i) an in-lesion region of interest for morphology-related concepts and (ii) a posterior acoustic band for posterior phenomena. We train concept maps using a grouped spatial grounding objective and preserve semantic faithfulness with a linear bottleneck classifier. Across five-fold stratified group cross-validation, the proposed SG-CBM improves diagnostic AUROC and concept macro-AUROC while markedly increasing spatial alignment of concept evidence. We also perform a Train-corrupt/Test-clean annotation-quality stress test to quantify the impact of supervision quality on diagnosis and spatial faithfulness. Overall, the results underscore the need for data-quality-aware supervision design and systematic trustworthiness validation for deployable healthcare AI systems.
Multimodal Attention-based Deep Learning for Emergency Triage with Electronic Health Records
Accurate emergency triage decision is critical to avoid clinical deterioration, morbidity, and mortality. Machine learning-based triage system involves acquiring the main presenting complaint in text form and assessing vital signs in numerical data, enabling an automated and efficient analysis of patient information for timely and accurate prioritization of medical attention. However, modelling the intricacies of both data types requires a comprehensive understanding of the temporal structure and dependencies within the data. Thus, the aim of this study is to propose a multimodal deep learning architecture that can effectively handle both tabular and textual data. Furthermore, the proposed model exploits self-attention to to capture both local and global relationships between the features. A dataset consisting of 11,102 triage data collected from emergency department of Hospital Universiti Sains Malaysia is used for model development and validation. The proposed model demonstrated an increase of 1.95% in accuracy, 2.49% in F1-score, and 1.41% in ROC AUC compared to the baseline model. The experimental results demonstrated the potential of the proposed model in predicting triage decisions.
Acquisition state behaves as a structured, measurable variable governing lung-nodule AI: kernel-driven measurement instability and noise-driven detection fragility, invisible to DICOM metadata
AI governance for medical imaging is formalizing: the 2026 ACR-SIIM Practice Parameter recommends local acceptance testing and ongoing drift monitoring, and the ACR Assess-AI registry monitors AI outputs using DICOM metadata for context. We argue that a necessary, currently unmonitored layer sits beneath output metrics: whether incoming studies remain within the acquisition envelope a model was validated on. Using a LUNA16-trained MONAI RetinaNet lung-nodule detector, we test whether acquisition state behaves as a structured, measurable variable. On real paired CT differing only in reconstruction kernel (NLST B30f vs B80f), kernel alone shifted AI-measured diameter and flipped a Fleischner size category in 5.2% (8 of 155) of nodules at fixed patient and acquisition, while detection confidence was unchanged (Wilcoxon p=0.22). Under controlled LIDC-IDRI perturbations the effects dissociated by axis: the noise axis degraded detection confidence (p=5.9e-32, concentrated in nodules under 6 mm) but not measurement, while the frequency/kernel axis corrupted measurement (p=8.6e-13) but not detection. A 4-feature pixel fingerprint recovered reconstruction identity (patient-level AUC about 0.95 on real CT, 0.995 on a QIBA phantom) where the ConvolutionKernel DICOM tag was uninformative (identical labels across reconstructions). The kernel axis transported across four manufacturers (leave-one-vendor-out AUC 0.94-0.98, matching the within-vendor ceiling). Acquisition state thus maps to distinct AI failure modes, frequency content to measurement reliability and noise to detection sensitivity, and is not recoverable from metadata. Acquisition-aware, input-side validation is the missing layer for the acceptance-testing and drift-monitoring requirements now entering imaging-AI accreditation.
What Demonstration Curation Metrics Do to Your Policy
We study whether demonstration-curation metrics that detect defective training episodes also improve the downstream behavior-cloning policy that trains on the curated data. On a contact-rich LIBERO pick-and-place benchmark with a controlled structural defect (early gripper release during the carry phase), we find that the two quantities are sharply decoupled. The metric with the highest defect-detection AUROC (0.804) produces the worst curated policy (13.3% task success), while a metric with a substantially lower AUROC (0.638) produces a policy that nearly matches the oracle trained on ground-truth clean data (90.0% vs. 93.3%). We further show that five of the seven metrics we evaluate exploit episode length as a trivial proxy for the defect label, a confound that inflates reported AUROCs to near-perfect values and disappears once episode length is controlled. Across all conditions, the contaminated baseline succeeds on only 3.3% of rollouts, and the two best curation methods close this to within 3 percentage points of the 93.3% oracle ceiling. Our results argue that curation methods should be evaluated by the policy they produce, not the defects they flag, and that any curation benchmark must control for episode length before reporting detection accuracy. We release the testbed, all metric implementations, and the evaluation pipeline.
Structural Grid Descriptors Predict Within-Task Solver Success on ARC-AGI
We ask whether structural properties of intermediate grid states predict whether a symbolic ARC-AGI solver will succeed, framed as a test of conditional mutual information I(X;Y|task) > 0. Across 44,800 runs spanning two architecturally distinct solvers (beam search and Stochastic DFS), 400 ARC tasks, 28 configurations per solver, and both training and evaluation splits, hand-crafted grid descriptors measured at 50% trajectory completion discriminate successful from failed runs within the same task (mean within-task best-feature AUC = 0.885, p < 0.001 under within-task label permutation). Most predictive content lies along a single grid-complexity axis. The result generalizes across solver architectures: a feature selected on one solver predicts success on the other with AUC 0.747-0.762 in all four transfer directions (p < 0.001, leakage controlled). On a pre-registered held-out set of 41 reliable tasks, the frozen feature n_components_final achieves AUC = 0.765 (95% CI [0.717, 0.810], p < 0.001), robust under task-clustered bootstrap resampling and cross-solver task collapsing. The signal is not explained by solver capacity (configuration-residualized AUC = 0.927 and 0.896 for beam search and SDFS, p < 0.001) and is only weakly coupled to score trajectories (R^2 approximately 0). Early stopping at 50% completion reduces beam-search compute by 33.6% while retaining 98.9% of solves; degenerate-trajectory detection reduces SDFS compute by 65.3% with no solve loss. Finally, on 229 of 400 evaluation tasks the DSL primitive library produces no valid transition from the input grid. This 0-step collapse is invariant to search budget and universally failed by beam search, indicating a DSL coverage limitation rather than a search-budget effect.
ATLAS: All-round Testing of Long-context Abilities across Scales
Long-context language models now advertise context windows up to millions of tokens, yet evaluations typically report a single length or a narrow task family, masking two failure modes: performance can collapse as length grows, and strong retrieval need not transfer to downstream use. We present ATLAS, a benchmarking framework that redefines long-context evaluation as length-dependent capability profiling. ATLAS contributes three methodological principles:(i) a layered taxonomy separating foundational operations from application workloads so failures can be attributed, (ii) length-aware AUC scoring that integrates score-length curves over a fixed 8K-1M grid, replacing single-point metrics with full degradation profiles, and (iii) ATLAScore, a harmonic-mean aggregate over taxonomy categories that penalizes imbalanced profiles, with end-to-end uncertainty propagation from subset scores through the nonlinear final aggregate. We instantiate the framework across eight capability dimensions with nine auditable components and 6,438 instances, and evaluate 26 models. Gemini-3.1-Pro-Preview leads at 128K, Claude-Opus-4.6 leads at 1M. Rankings reshuffle substantially between ATLASscore@8K-128K and ATLASscore@8K-1M: 7 models move by at least two ranks, and the two taxonomy layers share only 61% of cross-model variance, with individual rank gaps up to 12 positions. These results support reporting long-context quality by capability and length, not by a single headline score.
ROC Analysis for Evaluating Translation Quality Estimation Systems
The increasing use of automated translation quality estimation (QE) systems calls for practical, decision-oriented methods for evaluating their performance. We propose that Receiver Operating Characteristic (ROC) analysis is a useful approach for this purpose. Our study shows that ROC analysis not only produces results consistent with currently prevalent methods, but also offers several important advantages, including actionable performance insights that support business decision-making.
Worst-Group Equalized Odds Regularization for Multi-Attribute Fair Medical Image Classification
Diagnostic performance in medical AI varies systematically across demographic groups, yet subgroup AUC can mask clinically important disparities. At a fixed inference-time operating point, some groups may exhibit over-diagnostic behaviour, characterized by elevated true and false positive rates, while others show under-diagnostic patterns with reduced true and false positive rates. These opposing tendencies can cancel in aggregate AUCs while producing meaningful inequities in clinical decision-making. Motivated by the need to assess and mitigate such disparities at the operating point and across multiple demographic attributes simultaneously, we propose a worst-group equalized-odds margin regularizer. The proposed regularizer explicitly targets subgroup-level deviations on both the true positive and false positive sides at inference. At each update, the method identifies subgroups defined by explicit demographic attributes (e.g., age, sex, and race) that exhibit the most extreme margin deviations and applies a unified penalty, enabling fairness optimization across multiple demographic axes without requiring explicit intersectional constraints. Across two medical imaging datasets in realistic multi-label settings, our method consistently reduces disparities in Equalized Odds and Equalized Opportunity with minimal impact on AUC, preserving diagnostic performance while improving fairness.
Learning Interpretable Point-Based Clinical Risk Scores via Direct Optimization
Many clinical risk scores are deployed as additive rules with nonnegative integer points assigned to relevant binary predictive features. These integer weights not only make the score easier to use in practice but also promote sparsity in the resulting prediction model. Such risk scores are often derived by first fitting a regression model and then rounding the estimated coefficients to the nearest integer after appropriate scaling. This approach is computationally fast but does not guarantee optimality of the resulting score. Alternatively, one may search over all possible integer weights to directly optimize a value function by posing the problem as an integer programming task. However, the associated computational burden can be substantial, especially when the value function is nonconcave or even discontinuous. In this paper, we develop new machine learning algorithms that employ a flexible greedy optimization strategy to learn such additive scoring directly under explicit and sensible optimality objectives. We apply the proposed method to a large electronic health record (EHR) cohort in Epic Cosmos to construct an integer-weighted comorbidity score for measuring the risk of post-discharge mortality. We also conduct a simulation study to examine the finite-sample operating characteristics.
Confidence Geometry Reveals Trace-Level Correctness in Large Language Model Reasoning
Large language models (LLMs) generate not only reasoning text, but also token-level confidence trajectories that record how uncertainty evolves during inference. Whether these trajectories are relevant to reasoning correctness remains unclear. Here we show that confidence trajectories encode a content-agnostic confidence geometry associated with trace-level final-answer correctness. Using only token-level confidence values, without access to the input question, reasoning text, hidden states, or external verifiers, we find that low-dimensional representations of confidence trajectories separate correct from incorrect reasoning traces. Across GSM8K, MATH, and MMLU, this geometric separation is quantitatively linked to downstream predictability: stronger clustering of correct and incorrect traces, measured by the Davies--Bouldin index, consistently corresponds to higher correctness-discrimination AUC. We further show that correctness-related information is enriched in the tail of reasoning, suggesting that late-stage confidence dynamics carry key correctness signals. We propose NeuralConf, a lightweight estimator that learns from confidence trajectories for correctness evaluation. Under a fixed trace budget, NeuralConf-derived scores improve confidence-weighted answer aggregation over majority voting, tail confidence, and other static baselines. These results reveal that LLMs expose trace-intrinsic statistical signals of correctness through their own confidence dynamics, offering a route to improve inference using information already present within generation.
Decomposing the Generalization Gap in PROTAC Activity Prediction: Variance Attribution and the Inter-Laboratory Ceiling
Machine-learning predictors of biochemical activity often exhibit large random-split-to-leave-one-target-out generalisation gaps that have been documented but not decomposed. We frame this as an evaluation-science question and use targeted protein degradation as the empirical test bed. PROTACs (proteolysis-targeting chimeras) are heterobifunctional small molecules that induce targeted protein degradation, with more than forty candidates currently in clinical trials; published predictors report AUROC of 0.85 to 0.91 under random-split cross-validation, while the leave-one-target-out (LOTO) protocol of Ribes et al. reduces performance to approximately 0.67. Random splits reward within-target interpolation, whereas LOTO measures the novel-target prediction that de-novo design depends on. We decompose this gap and identify inter-laboratory measurement variance as the dominant component, anchored by a within-target cross-laboratory cascade bounding the inter-laboratory contribution at 0.124 AUROC, well above the 0.05 contribution from binarisation-threshold choice. Across eight published architectures and ESM-2 protein language models up to 3B parameters, LOTO AUROC plateaus near 0.67, with a comparable plateau under SMILES-level deduplication; a 21-dimensional 2000-trial hyperparameter optimisation cannot break this ceiling, and the rank-1 single-seed configuration regresses by 0.161 AUROC under multi-seed validation, matching a closed-form selection-bias prediction (Bailey and Lopez de Prado, 2014). Few-shot k=5 stratified per-target retraining combined with ADMET features lifts 65-target LOTO AUROC from 0.668 to 0.7050, and post-hoc Platt scaling recovers raw output to within the 0.05 well-calibrated threshold. We release PROTAC-Bench (10,748 measurements, 173 targets, 65 LOTO folds), the variance-decomposition framework, the per-target calibration protocol, and the evaluation code.
Hallucination Detection via Activations of Open-Weight Proxy Analyzers
We introduce a proxy-analyzer framework for detecting hallucinations in large language models. Instead of looking inside the generating model, our system reads already-generated text through a small locally hosted open-weight model and spots hallucinations using the reader's own internal activations. This works just as well when the generator is a closed API like GPT-4 as when it is any open-weight model. We built eighteen features grounded in how transformers process text, covering residual stream norms, per-head source-document attention, entropy, MLP activations, logit-lens trajectories, and three new token-level grounding statistics. We trained a stacking ensemble on 72,135 samples from five hallucination datasets. We tested across seven analyzer architectures from 0.5 billion to 9 billion parameters: Qwen2.5 at 0.5B and 7B, Gemma-2 at 2B and 9B, Pythia at 1.4B, and LLaMA-3 at both 3B and 8B. Across all seven, we consistently beat ReDeEP's token-level AUC of 0.73 on RAGTruth by 7.4 to 10.3 percentage points. Qwen2.5-7B reached an F1 of 0.717, just above ReDeEP's 0.713, while Qwen2.5-0.5B hit 0.706. The most striking finding is how tightly all seven models cluster: AUC spans only 2.3 percentage points across an eighteen-fold difference in model size. Even more surprising, our 3B LLaMA outperforms our 8B LLaMA on RAGTruth, showing that bigger is not always better even within the same model family. Both RAGTruth and LLM-AggreFact include outputs from multiple LLM families, so our results are not skewed toward any particular generator.
Intermediate Representations are Strong AI-Generated Image Detectors
The rapid advancement in generative AI models has enabled the creation of photorealistic images. At the same time, there are growing concerns about the potential misuse and dangers of generated content, as well as a pressing need for effective AI-generated image detectors. However, current training-based detection techniques are typically computationally costly and can hardly be generalized to unseen data domains, while training-free methods fall short in detection performance. To bridge this gap, we propose a search-based method employing data embedding sensitivity in intermediate layers to detect AI-generated images. Given a set of real and AI-generated images, our method examines the similarity between original image embeddings and perturbed image embeddings, and detects AI-generated images based on the similarity. We examine the proposed method on two comprehensive benchmarks: GenImage and Forensics Small. Our method exhibits improved performance across different datasets compared to both training-free and training-based state-of-the-art methods. On average, our method achieves the largest performance gain on the Forensics Small benchmark by 39.61% compared to the best training-free method and 5.14% compared to the best training-based method in AUROC score.
Beyond ECE: Calibrated Size Ratio, Risk Assessment, and Confidence-Weighted Metrics
Confidence calibration has been dominated by the Expected Calibration Error (ECE), a linear metric that counts calibration offset equally regardless of the confidence level at which it occurs. We show that ECE can remain small even under arbitrarily large overconfidence risk, so we propose Calibrated Size Ratio (CSR) instead, an interpretable metric that equals 1 under perfect calibration, from which we derive the risk probability that quantifies the statistical evidence for overconfidence. We further argue that overconfidence risk assessment must be complemented by a measure of discriminative value: whether the assigned confidences actively distinguish correct from incorrect predictions. We show that confidence-weighted accuracy is the natural such complement, and that confidence-weighting extends to all standard classification metrics. In particular, we prove that the confidence-weighted AUC (cwAUC) captures the information about calibration while the classical AUC cannot. We validate the proposed indicators on several synthetic confidence distributions under multiple controlled calibration profiles and find that CSR separates risky from non-risky assignments. We also test the metrics on fifteen real datasets, with and without post-hoc calibration, and find that standard methods can yield risky confidence profiles.
Deployment of AI-Assisted Interventions: Capacity Constraints and Noisy Compliance
AI tools increasingly drive targeted interventions in various service settings, including healthcare, education, and public services. Algorithms score individuals, trigger outreach to those above a threshold (e.g., high-risk or high-value), and encourage them to request service; then providers deliver service to those who request. Much of the work in this area has focused on improving predictive accuracy, implicitly assuming that better predictions lead to better outcomes. We show that predictions are only one component of a larger service system: when service capacity is limited and behavioral responses to outreach are probabilistic, system efficacy depends on operational forces that predictive accuracy does not capture. In such settings, the optimal score threshold must balance two effects: ensuring all capacity is filled (utilization) and, when capacity is constrained, preventing low-value requests from crowding out high-value ones (cannibalization). We characterize the optimal threshold and prove that thresholds based solely on predictive accuracy are generally suboptimal. Further, algorithm selection metrics such as AUC can be misaligned with operational performance: they weight all thresholds equally, while optimal deployment uses a subset of thresholds that depends on both capacity and compliance behavior. We introduce a new metric, Operational AUC (OpAUC), and show that it identifies the efficacy-optimal algorithm. Finally, we conduct a case study on sepsis early warning data that illustrates the magnitude of the improvement available from better threshold selection and shows that a predictor with lower AUC can achieve higher system efficacy under optimal deployment.
Federated Computation of ROC and PR Curves
Receiver Operating Characteristic (ROC) and Precision-Recall (PR) curves are fundamental analytical tools for evaluating classification models, providing a comprehensive view of performance across decision thresholds. In modern data management settings, such evaluation must often be performed over data that is distributed across multiple parties and subject to strict privacy constraints. This setting arises naturally in federated learning (FL) and collaborative data platforms, where raw prediction scores and labels cannot be centrally collected. We study the problem of computing ROC and PR curves over distributed data under formal privacy guarantees. The key challenge is that exact computation requires access to all prediction scores and labels, leading to linear communication costs and privacy risks. To address this, we propose a novel framework for approximating ROC and PR curves using quantiles of the score distribution, which can be computed efficiently under secure aggregation and distributed differential privacy. Our approach requires only communication, where is the number of quantiles, and avoids sharing raw data entirely. We provide theoretical guarantees on the approximation quality by bounding the Area Error (AE) between the true and estimated curves, demonstrating principled trade-offs among approximation accuracy, privacy protection, and communication cost. Our method is robust to data heterogeneity and skew, making it suitable for real-world distributed data management scenarios. Experiments on real-world datasets show that our approach achieves high accuracy with low communication overhead under strong privacy constraints. Overall, this work provides a practical and theoretically grounded solution for privacy-preserving evaluation of classification models over distributed data.