Single-Photon Avalanche Diode

Quantum communication underpins secure information processing and scalable quantum networks. In particular, remote state preparation (RSP) enables efficient quantum state transfer, but accurately estimating target states under complex noise remains challenging. Here, we propose a Transformer-based Quantum State Characterizer (TQSC) model for noisy RSP experiments. Our model reconstructs experimentally prepared pure and mixed photonic polarization states from noisy measurements in complex scattering environments, while its attention patterns provide physically grounded insights into correlations among the measured observables. The method achieves a mean estimator-target fidelity exceeding 99.999% under complex scattering and dynamic Gaussian noise, while its robustness and generalization are further examined using Qiskit-simulated Bloch-ball states.Furthermore, in a practical MNIST image transmission task with held-out states, the decoded bit error rate is reduced from 50.34% to zero after TQSC post-processing. The TQSC model enables accurate tomographic characterization under dynamic noise and provides physically grounded post-hoc insights, holding promise for intelligent quantum information processing applications.

Low-dose computed tomography (LDCT) measurements contain mixed Poisson-Gaussian noise. However, most self-supervised methods rely on generic image statistics and do not explicitly model this noise, which may limit their ability to effectively suppress realistic LDCT noise. To address this issue, we propose a physics-driven framework with cross-domain iteration for self-supervised LDCT denoising. The proposed framework proceeds in three main steps. First, a learned sinogram prior and the LDCT noise model guide posterior inference of photon counts, enabling separation of the Poisson and Gaussian components. Second, the separated Poisson and Gaussian components are respectively processed by binomial thinning and Gaussian data thinning to construct two branches, and residual scaling matches each branch's noise level to that of the observation, yielding a training pair with approximately independent noise realizations from one low-dose measurement. Finally, the pair is used to train an image-domain network whose forward-projected outputs update the prior. Through cross-domain iteration, the prior and the training pair are progressively refined while maintaining consistency with CT acquisition physics. Experiments on simulated data from AAPM, LIDC-IDRI, and LoDoPaB-CT and on real LDCT data show consistent gains over the evaluated self-supervised baselines across dose levels, with performance comparable to the evaluated supervised baseline.

Pixel permutation is a fundamental tool in image processing, image encryption, and data hiding (including watermarking and steganography) that rearranges pixels without changing their values. A common assumption in the literature is that permutation alone cannot create differential sensitivity; changing one pixel merely relocates that pixel in the output, producing no avalanche effect. This paper challenges this by introducing the Triangular Content-Aware Permutation (TCA) algorithm. The method extracts edge points using Canny and applies Delaunay Triangulation to edges and corners, creating a unique partition. Since triangulation is highly sensitive to image geometry, changing a single pixel alters the edge map, resulting in a completely different triangulation and global permutation pattern. Unlike classical dimension-based permutations and advanced content-aware methods (2025-2026), which lack differential sensitivity, TCA increases NPCR from near-zero to 97.10% solely through pixel relocation. Experiments on 50 images show that TCA, with an average of 14.81 iterations, achieves NPCR = 97.10% and UACI = 20.06%, proving pure permutation can create significant differential sensitivity. Conventional methods maintain near-zero NPCR. The iteration threshold varies from 6.4 to 30.7 based on content complexity. Low PSNR (11.93 dB) and near-zero correlation (~10^-3) confirm superior statistical performance. Although slower than classical methods due to triangulation, this is a deliberate trade-off for stronger security. Given the non-analytic, content-dependent nature of the pattern, TCA is ideal for reference-based encryption, fragile watermarking, and non-blind steganography.

Optical flow remains challenging in high-speed and low-light scenes, where the limited frame rate and sensitivity of conventional cameras lead to motion blur and underexposure. Single-photon avalanche diode (SPAD) cameras offer single-photon sensitivity and extremely fine temporal sampling. However, individual slices in these high FPS binary photon streams are too sparse for dense correspondence. Temporal aggregation can provide the spatial cues required by optical flow, but accumulating photons at fixed coordinates blurs moving structures. Motion-aware aggregation can reduce this blur, yet it depends on the flow being estimated. To address this dependency, we propose QuantaFlow, the first method for dense optical flow directly from SPAD streams. Instead of constructing a fixed input representation, QuantaFlow embeds SPAD representation construction into iterative flow refinement. At each iteration, the current flow coarsely aligns the slices within the source and target sub-streams. A photon-flux transformation then constructs multi-scale representations containing intensity and structural cues, while adaptive multi-scale fusion balances photon noise and residual motion blur at each pixel. The fused representations drive a feature-warping flow update, and the refined flow guides representation construction in the next iteration. We further construct a synthetic dataset for SPAD optical-flow training and evaluation. Experiments on the synthetic dataset and real-world SPAD data demonstrate the effectiveness and generalization of QuantaFlow.

Single-photon avalanche diode (SPAD) cameras are promising for low-light and high-dynamic-range intensity imaging, but their practical use is limited by complex sensor-specific noise. Unlike time-correlated single-photon counting (TCSPC) systems, SPAD cameras record whether at least one detection occurred in each gate without photon timestamps in intensity imaging mode, making explicit noise decomposition difficult. We present a practical noise modeling and calibration framework for SPAD intensity denoising. Our forward model describes binary-frame accumulation with a Binomial observation process, models signal-independent dark noise as an exposure-dependent pure dark count term plus an exposure-independent dark-frame bias term, and incorporates pixel-wise response non-uniformity. We design a dedicated calibration procedure for the proposed model and use it to build a count-domain noise-synthesis pipeline for network training. For denoising, we further design a SPAD-specific dark-shading correction (SPAD-DSC) to remove most systematic noise before network training. We construct a real-world SPAD intensity dataset for testing. Experimental results demonstrate the superiority of the proposed noise model.

PET provides functional images relying on two-photon coincidences from positron-electron annihilation. In human tissue, about 40% of annihilations are preceded by Ps formation, of which o-Ps component partially decays into three photons, with the remainder annihilating via pick-off or spin-exchange into two photons. This three-photon channel carries additional information about the surrounding micro-environment, including the three-to-two-photon yield ratio as a potential diagnostic marker. We propose the TRIO algorithm, a novel three-photon event-by-event image reconstruction algorithm formulated as a Bayesian maximum a posteriori inference problem. TRIO unifies time-based trilateration, energy-based reconstruction and, for the first time, a physics-informed prior derived from the QED description of Ps decay within a single probabilistic framework. In contrast to positronium lifetime imaging, which requires a prompt photon and is therefore restricted to specific radionuclides, TRIO relies solely on the three photons and is fully compatible with standard radionuclides such as 18F. Monte Carlo simulation modelled after the Siemens Biograph Quadra scanner demonstrates a mean position error of 1.62~cm, improving by approximately a factor of two over the time-based trilateration (3.05 cm) and by about an order of magnitude over energy-based reconstruction alone (18 cm). More importantly, the proposed Bayesian approach is compatible with existing TOF-PET scanners that can register three-photon annihilation coincidences.

Photonic reservoir computing is a promising physical machine-learning technique for predicting time-series data. The quantization of the response signal from the reservoir is required for the implementation of photonic reservoir computing, and the number of quantization bits and sampling frequency need to be optimized to achieve high performance and low energy consumption. However, few studies have been reported to investigate the effect of bit quantization and sampling frequency. In this study, we introduce a concept of approximate reservoir computing with a semiconductor laser by quantizing the amplitude of node states in the reservoir and output weights. We evaluate the performance of a chaotic time-series prediction task and energy consumption per sample. We achieve significant reduction of energy consumption by optimizing the number of quantization bits, the sampling frequency, and the injection current of the semiconductor laser, while maintaining the prediction performance.

Quantum devices are open systems whose dynamics interleave coherent evolution with dissipation, and benchmarking, error mitigation, and error correction all rest on a faithful model of both. Existing characterization protocols either assume prior knowledge of the interaction and noise structure, or demand ancillas, entangled probes, or mid-circuit control, or capture only the Pauli-diagonal part of the noise. Here, we present a protocol that reconstructs an arbitrary sparse Markovian generator, including every Hamiltonian together with the jump operator coefficients, using only product Pauli state preparation, single uninterrupted forward evolutions, and product Pauli measurements. Given a sparsity budget $M_0$ and a strength bound $Γ$ of the Lindbladian, every coefficient is learned to precision $ε$ from $\widetilde{O}(Γ^2M_0^2/ε^4)$ experiments and $\widetilde{O}(ΓM_0^2/ε^2)$ total evolution time, with both supports identified from data without locality assumptions. The protocol runs at a logarithmic number of positive evolution times on a hardware clock lattice and is provably robust to calibrated state-preparation and measurement errors.

Physical noise in near-term quantum hardware is usually treated as a nuisance to suppress. We ask whether it can instead act as a hardware-native regularizer for photonic hybrid quantum-classical neural networks (PHQCNNs), analogous to noise-injection regularization in classical deep learning. Using Quandela's Perceval simulator and the MerLin framework, we build PHQCNNs for Iris, Digits, and MNIST and inject Perceval's seven-parameter physical noise model directly into training. A genetic algorithm searches the six continuous noise dimensions and 1 boolean parameter to find, per dataset, the configuration maximizing validation accuracy, compared against a noiseless baseline across five seeds. GA-tuned noise yields modest accuracy gains on Iris (+0.82pp) and Digits (+1.45pp), but a clear degradation on MNIST (-1.21pp). Per-parameter sweeps show that no individual noise parameter is consistently beneficial, motivating the joint search, while a second-order loss expansion shows that physical noise induces a Tikhonov-like regularization term whose effect is dataset-dependent. Physical photonic noise can thus act as a free regularizer, but not universally.

Sparse-support uncertainty is usually quantified by treating the dictionary as known, an assumption that can produce overconfident, label-dependent conclusions when the dictionary is learned from latent sparse mixtures. Near collisions of coherent atoms, a test signal may identify the active physical group even though the training data cannot distinguish the physical rays within it. We develop inference for active physical rays, unit atoms modulo sign, after latent dictionary learning. In a fixed-dimensional Gaussian train-test experiment, we retain all dictionaries compatible with a robust training-moment region, profile the test representation over them, and project surviving configurations onto a permutation-invariant support space. The resulting confidence correspondence can report cross-sheet inconclusiveness, group resolution with child ambiguity, or fine-support resolution. We characterize both its statistical cost and decision-theoretic benefit. Residual block orientation first affects the latent training density at cubic order, yielding information of order $s^6$, where $s$ is the within-block collision scale. The correspondence provides high-probability-over-training conditional test coverage, with resolution governed separately by parent detectability, test-time support separation, and learned-dictionary orientation. In the resolved fixed-shell regime, its projective Hausdorff diameter contracts at the minimax-optimal rate $s \wedge (\sqrt{N}s^2)^{-1}$, up to constants. A restricted-task theorem further determines when coefficient asymmetry allows test replication to supplement training information and when calibration uncertainty remains irreducible. The framework thus yields honest, resolution-adaptive support statements and guides the allocation of training versus test measurements.

Low-Gain Avalanche Diodes (LGADs) and AC-coupled Low-Gain Avalanche Diodes (AC-LGADs) are promising technologies for precision timing and four-dimensional tracking. In AC-LGADs, the AC pad is coupled to the resistive n$^{+}$ layer through a dielectric layer, while the gain layer remains unsegmented. This structure provides a 100% fill factor and enables good spatial resolution with a relaxed readout pitch. The same signal-sharing mechanism that makes interpolation possible complicates the readout: charge spreads across multiple pads, the useful information can approach the electronic-noise threshold, and matrix-inversion approaches can become computationally challenging and sensitive to off-diagonal noise. In this work, we study machine-learning-based reconstruction and compression for resistive silicon sensors. We use full-waveform information from correlated pads to regularise the reconstruction and extract spatial information beyond what is available from binary readouts or reduced-amplitude summaries. We first introduce recurrent neural network models based on LSTM layers, which provide a proof-of-concept implementation for full-waveform reconstruction and have been tested for FPGA deployment using \hls. We also study routes towards bandwidth reduction with waveform rasterisation and window-selection methods, and extend the approach beyond the first model to topology-agnostic transformer-based architectures that use pad coordinates as part of the input. These models are designed to support arbitrary pad counts and geometries, mitigate edge distortions, preserve approximately $10~μ\mathrm{m}$ position resolution for $500~μ\mathrm{m}\times500~μ\mathrm{m}$ pitched sensors, and guide future resistive-silicon sensor designs

Single-Photon Avalanche Diode (SPAD)-based Light Detection and Ranging (LiDAR) is emerging for autonomous vehicles due to its high sensitivity and precise depth sensing capabilities. However, flare caused by excessive photon returns or pile-up effects can lead to incorrect depth estimation and exaggerated boundaries in point clouds, resulting in severe distortions of geometric measurements, making flare suppression essential for safety-critical applications. Existing flare mitigation methods primarily operate at the hardware or signal-processing levels. While effective under specific configurations, they are largely rule-based and configuration-dependent, lacking learnable representations that generalize across diverse sensing scenarios. In this work, we reformulate flare suppression as a semantic segmentation problem, enabling data-driven learning of geometric and photometric cues directly from SPAD measurements. We first benchmark representative segmentation models on the newly introduced SPAD flare dataset and observe that they struggle to exploit the intrinsic multi-echo characteristics of SPAD signals. Motivated by this observation, we propose Physically-Informed segmentation for LiDAR Flare (PILF), a learning-based approach that treats the first and second echoes, together with ambient illumination, as distinct modalities, aggregating cross-echo information while jointly encoding geometric and photometric features. Experiments across multiple real-world scenes demonstrate that PILF significantly outperforms compared segmentation models, achieving up to 79.32% mIoU, and providing an effective solution for SPAD-based LiDAR flare suppression.

Direct time of flight (dToF) measurements are susceptible to errors because of system-level and circuit-level timing jitters. In addition, device-level uncertainty stemming from the dark noise of single-photon avalanche diode (SPAD) contributes to the aggregated error. We demonstrate that perimeter gating can help reduce the device-level detection inaccuracy for SPAD devices by reducing the dark noise probability. Specifically, in this work, we developed a general framework to accurately estimate the dToF jitters stemming from different source levels and analyzed a counter-based time to digital converter (TDC) circuit that are commonly used in such systems. We have also measured dToFs using a perimeter-gated SPAD (pg-SPAD) detector fabricated in a 0.35 $μ$m standard CMOS process. Experimental results show that pg-SPADs can improve measurement accuracy in both free-running and time-gated operations.

Photonic quantum machine learning offers a route to trainable physical representations built from phase, interference and measurement. However, its role in scientific machine learning remains largely unexplored. Physics-informed neural fields provide a natural setting, because differential equations require trial spaces that preserve phase, frequency and derivative structure. Here we introduce a photonic quantum neural field in which coordinates become trainable optical phases, are mixed by multi-photon Fock-space interference and are decoded from photon-number measurements. The photonic circuit is optimized as the neural-field representation itself, not as a fixed feature map or hardware accelerator. Photonic measurement is therefore a trainable representation on which the physics-informed residual is minimized. Across seven elliptic, wave, nonlinear dispersive and inverse PDE benchmarks, we observe a phase-complexity transition: classical coordinate and Fourier-feature networks suffice in smooth regimes, whereas the photonic field is most accurate when residual derivatives amplify phase mismatch. In the hardest regimes it gives the lowest errors, with margins reaching an order of magnitude and about one quarter of the trainable parameters of classical baselines. Frozen and shuffled controls, together with noise stress tests, attribute this gain to learned interference and stable Fock-probability readout under compound perturbations. These results identify photonic quantum measurement as a representation-learning principle for scientific machine learning.

Single-photon LiDAR (SPL) based on single-photon avalanche diode (SPAD) sensing enables time-resolved photon measurements with extreme sensitivity, offering unique potential for active 3D perception in photon-starved scenarios.However, real-world single photon perception remains fundamentally challenging due to unique measurement noise and complex multi-return transient phenomena, which jointly complicate geometric reconstruction and semantic scene understanding. Despite growing interest in SPAD-based sensing, existing studies are largely limited to simulated data or small-scale controlled captures. As a result, systematic evaluation of real-world single photon perception across depth estimation, multi-view reconstruction, and 3D semantic understanding remains underexplored. To bridge this gap, we introduce SP-TransientBench (STB), a real-captured multi-task benchmark for single photon perception. SP-TransientBenc comprises 10 diverse scenes and 10,297 views captured using a solid-state single-photon LiDAR at $256\times192$ resolution. Each view provides full time-of-flight histograms with multi-return behavior,standardized metadata, and calibrated camera poses for multi-view evaluation. We further provide 13-class 3D semantic annotations for selected scenes. By providing dedicated data splits and evaluation protocols for each task, STB enables consistent and reproducible benchmarking of real-world single photon perception across multiple 3D vision problems. The dataset and code will be released upon acceptance.

The goal of this work is to reduce the effect of photon noise in dental cone-beam CT reconstruction. We consider an inverse problem formulation and develop a databased prior. To this end, we simulate fan-beam acquisitions and add photon noise to the projection data. The prior is obtained by training a gradient-step denoiser using reconstructed simulated acquisitions. The trained model is integrated into a plug-and-play gradient-step algorithm to reconstruct images from simulated projections. Experiments on synthetic data demonstrate the denoising capabilities of the trained model, while qualitative evaluations on real images showcase the algorithm's performance and generalization ability.

Scintillation detectors with excellent timing resolution enable more precise localization of radiation sources in positron emission tomography, leading to substantial improvements in diagnostic capability for diseases such as cancer and dementia. At the extreme timing precision required for such applications at the picosecond scale, detector performance is governed by the microscopic dynamics of scintillation photons generated within the detector and their subsequent detection processes. However, detector signals have conventionally been treated only as collective responses of many photons due to structural constraints inherent to photodetectors. In this study, we overcome this fundamental limitation using deep learning, enabling direct access to the timing information of individual photons. The proposed method estimates photon-by-photon arrival times directly from detector waveforms without requiring any modification to the detector structure; the method operates on an event-by-event basis without ground-truth labels by integrating an unsupervised learning framework with a physically informed detector-response model. Through comprehensive validation combining Monte Carlo simulation and experimental measurements across various detector configurations, we experimentally demonstrate improved timing resolution, visualized depth-of-interaction-dependent photon transport, and classified Cherenkov and scintillation photons based on the estimated photon-level timing information using a unified deep learning-based framework. These results provide experimental access to photon dynamics, bridging the gap between theoretical modeling and experimental observation, and they open a new data-driven pathway for discovery in detector physics and optimization.

Photonic quantum computing is a promising platform for scalable quantum machine learning, but designing effective hybrid architectures remains challenging under hardware and optimization constraints. Existing approaches rely on manually tuned architectures that fail to account for the collaboration between classical preprocessing, phase encoding, and photonic circuit structure, limiting both accuracy and hardware compatibility. In this paper, we propose a neural architecture search framework for hybrid photonic quantum-classical models that combines genetic algorithm-based search with learnable quantum phase encoding to systematically explore the joint design space of classical and quantum components. Our framework encodes 19 hyperparameters across six gene groups and evolves a population of hybrid architectures using group-based crossover, per-gene mutation, and elitism, evaluating each candidate on a short training budget before full retraining of the best found design. We evaluate our framework on two image classification benchmarks, Digits and MNIST, achieving final validation accuracies of 99.44% and 98.78%, respectively, with first-principles execution time estimates on the Quandela Ascella photonic QPU projecting single-image inference at 67 ms (Digits) and 149 ms (MNIST). Our quantum contribution analysis further shows that the photonic layer extracts non-redundant features orthogonal to the classical pathway, providing a measurable accuracy advantage over classical-only baselines. Our results demonstrate that automated architecture search is both practical and impactful for hybrid photonic systems, opening the way for systematic design space exploration of quantum AI on photonic devices.

Physical computing systems provide a promising route toward hardware-native machine learning, but their computational capabilities remain difficult to characterize in a principled, task-independent, and data-efficient way. We extend the Information Processing Capacity (IPC) framework to stationary physical computing systems and establish several fundamental results: individual capacities are bounded between zero and one, their sum over a complete basis is bounded by the number of readouts, and noise strictly reduces this bound. We address the finite-sample estimation of IPC and derive the asymptotic form of the systematic positive bias affecting naive estimators. Building on these results, we introduce data-efficient estimation methods based on Richardson extrapolation and Sobol quasi-random sampling. We validate the framework experimentally using a photonic computing system based on picosecond laser pulses propagating through a nonlinear optical fibre. By varying the laser power and fibre length, we observe systematic shifts of the IPC distribution toward higher-order nonlinear capacities induced by the Kerr effect. Finally, we demonstrate that the total IPC strongly correlates with performance on benchmark machine-learning tasks and provides a reliable estimate of the effective dimensionality of the system. These results establish IPC as a practical bridge between the intrinsic dynamics of physical computing systems and their machine-learning performance.

Ghost imaging reconstructs spatial information from a single-pixel bucket detector by correlating structured illumination patterns with scalar intensity measurements. While deep learning approaches have achieved promising results on static scenes, two critical limitations remain unaddressed: existing architectures fail to exploit temporal coherence across frames, leaving dynamic ghost imaging largely unsolved, and they assume additive Gaussian noise models that do not reflect the true Poissonian statistics of real single-photon hardware. We present DynGhost (Dynamic Ghost Imaging Transformer), a transformer architecture that addresses both limitations through alternating spatial and temporal attention blocks. Our quantum-aware training framework, based on physically accurate detector simulations (SNSPDs, SPADs, SiPMs) and Anscombe variance-stabilizing normalization, resolves the distribution shift that causes classical models to fail under realistic hardware constraints. Experiments across multiple benchmarks demonstrate that DynGhost outperforms both traditional reconstruction methods and existing deep learning architectures, with particular gains in dynamic and photon-starved settings.

Optical readout in low-light imaging is fundamentally limited by measurement noise, including photon shot noise, detector noise, and quantization error. In this regime, downstream inference depends not only on the optical front end, but also on how noisy high-dimensional sensor measurements are represented before classification or decision-making. Here we show that eigentasks provide a measurement-adapted representation for optical sensor outputs by ordering readout features according to their resolvability under noise. Using experimental data from a lens-based optical imaging system and a reanalysis of published data from a single-photon-detection neural network, we find that eigentask representations frequently outperform standard baselines including principal component analysis and filtering-based compression. The advantage is most pronounced in photon-limited, few-shot, and higher-difficulty classification regimes. In few-shot MPEG-7 classification, for example, the advantage over other methods reaches about 10 percentage points as the number of classes increases. In these settings, eigentasks yield more informative low-dimensional features and improve sample-efficient downstream learning. These results identify measurement-adapted representation as a promising strategy for optical inference when photon budget, acquisition time, and task complexity are constrained.

Accurate, unified models for event cameras (ECs) remain elusive, hampering calibration and algorithm design. We develop a foundational probabilistic model for EC event detection, grounded in photon statistics, that unifies the description of static scene noise events and step response curves (S-curves) within a single analytical framework. Three formulations of the probability distributions are derived, spanning all intensity regimes: exact Poisson, saddle-point, and Gaussian. The model reveals the underlying connection between these otherwise disparate EC behaviors and clarifies the interpretation of S-curves, which we show is more nuanced than selecting a fixed probability threshold. Based on this model, we propose Noise2Params, a method for determining camera-specific values of the log-contrast threshold $B$, the lux-to-photon conversion factor $α$, and the leakage term $θ$ (found to be intensity dependent), via error minimization against observed noise-event distributions. Noise2Params requires only recordings of static, uniform scenes, offering an experimentally accessible alternative to approaches that demand specialized dynamic light sources. We further support the validity the model by training convolutional neural networks (CNNs) on synthetic noise images generated from our distributions and evaluating their ability to reconstruct static scenes from experimental data. We further demonstrate the utility of our model by showing that CNNs incorporating synthetic data outperform those trained solely on experimental data. Our framework provides a quantitative foundation for EC calibration, noise-aware algorithm design, and applications in photon-limited regimes.

Using reinforcement learning, we optimize for practical hardware constraints, including limited FIR filter taps at the transmitter and receiver, mean photon number and finite DAC/ADC resolution. Under these realistic conditions, the proposed approach achieves significant performance improvements.

We present a Mixture-of-Experts-based foundation model applied to the GlueX DIRC detector at Jefferson Lab, demonstrating its utility as a unified framework for fast simulation, particle identification, and hit-level noise filtering of Cherenkov photons. By leveraging a single shared transformer backbone across all tasks, the approach eliminates the fragmentation of task-specific pipelines while maintaining competitive-and in several cases superior-performance relative to established methods. The model operates directly on low-level detector inputs, performing hit-by-hit autoregressive generation over split spatial and temporal vocabularies with continuous kinematic conditioning, and supports class-conditional generation of pions and kaons through its Mixture-of-Experts architecture. We benchmark against the standard geometrical reconstruction and prior deep learning methods across the full kinematic phase space of the GlueX DIRC, demonstrating that the foundation model framework transfers effectively to this detector without architectural modification. This work positions the foundation model as a practical and scalable alternative to the suite of task-specific models currently proposed for GlueX DIRC analysis.

Portable CT scanners may support earlier stroke assessment, but reduced photon counts introduce noise that affects image quality and may alter automated classification. We compared direct classification of simulated low-dose slices with residual U-Net denoising followed by the same fixed classifier. Poisson noise was generated at photon-count scaling factors of 1, 5, 10, 20, and 40 using three deterministic seeds. The held-out set contained 809 slices, including 242 positive and 567 negative slices. Direct classification reached its highest mean ROC-AUC at a scaling factor of 20 (0.937 +/- 0.002). Denoising followed by classification reached 0.842 +/- 0.005 at a scaling factor of 1 and declined to 0.655 +/- 0.002 at a scaling factor of 40. Meanwhile, reconstruction quality rose steadily from 21.92 to 40.91 dB PSNR and from 0.761 to 0.987 SSIM. Both pathways had poor sensitivity at a fixed 0.5 cutoff because their classification scores were concentrated near zero. Patient-level analysis was limited by the test-set composition: all 10 patients were positive under the mask-derived patient label, preventing estimation of patient-level AUC and specificity. Overall, higher reconstruction fidelity did not translate into better discrimination by the fixed classifier except at the lowest photon-count setting.

Astronomical imaging remains noise-limited under practical observing conditions. Standard calibration pipelines remove structured artifacts but largely leave stochastic noise unresolved. Although learning-based denoising has shown strong potential, progress is constrained by scarce paired training data and the requirement for physically interpretable models in scientific workflows. We propose a physics-based noise synthesis framework tailored to CCD noise formation in the telescope. The pipeline models photon shot noise, photo-response non-uniformity, dark-current noise, readout effects, and localized outliers arising from cosmic-ray hits and hot pixels. To obtain low-noise inputs for synthesis, we stack multiple unregistered exposures to produce high-SNR bases. Realistic noisy counterparts synthesized from these bases using our noise model enable the construction of abundant paired datasets for supervised learning. Extensive experiments on our real-world multi-band dataset curated from two ground-based telescopes demonstrate the effectiveness of our framework in both photometric and scientific accuracy.

Single-photon avalanche diodes (SPADs) record light as a discrete stream of individual detections. The signal is stochastic. Its statistical structure depends on the sensor's operation mode: binary detection in fixed bins, timestamped detection in fixed bins, or free-running timestamped detection. We derive the likelihood score function for each of these three passive modes. From this single object, stem both fundamental limits of recovery (Cramer-Rao bounds) and practical recovery algorithms based on diffusion posterior sampling. The paper further generalizes fundamental limits to Bayesian Cramer-Rao lower bounds. This generalization makes use of a learned approximation of the score function of signal priors. In prior art, analyses and diffusion-based reconstruction for SPAD data have treated individual modes in isolation. Our unified treatment shows a qualitative high-flux gap between modes: binary counts saturate exponentially, while timestamped modes degrade only linearly. We further extend diffusion posterior sampling, previously restricted to binary SPAD data, to a full timestamped case using the suitable score function. We demonstrate experimentally that matching the score to the operation mode is beneficial for high-fidelity reconstruction. By tying the recovery bounds and diffusion to the score function, this work aims to establish a common foundation for both asking what is recoverable in single-photon sensing, and building methods that approach the bound.

Ptychographic imaging at synchrotron and X-ray free-electron laser sources requires densely overlapping scans, which limits throughput and increases dose; extending coherent diffractive imaging to overlap-free operation on extended samples remains an open problem. We present a self-supervised inverse-mapping network for single-frame Fresnel coherent diffraction imaging (CDI) and overlapped ptychography with fixed, pre-estimated probes. The learned neural network reconstructs individual object patches from either one diffraction frame or several overlapping measurements at a time. In single-frame mode, the phase diversity provided by the curved-wavefront probe at the off-focus sample position removes the requirement for overlap constraints, enabling sparser scans and proportionally lower dose at fixed exposure. On synthetic line patterns, reconstructed amplitude SSIM exceeds 0.90 in single-frame mode with the curved probe and reaches 0.952-0.968 with overlap constraints. Optimization of the network via a Poisson negative log likelihood objective, rather than the more common mean absolute error, yields 10-fold improved photon-dose efficiency at doses below $10^5$ photons per image, where shot noise typically limits resolution. In addition to these synthetic studies, we demonstrate robust single-frame reconstruction of extended samples using ptychographic datasets from APS and LCLS, with end-to-end reconstruction of a 10,304-frame workload approximately $36\times$ faster than a highly optimized iterative solver. Together, these results unify single-frame Fresnel CDI and overlapped ptychography within one self-supervised framework, supporting dose-efficient, high-throughput imaging at modern light sources.