Autonomous Endovascular Navigation

Soft eversion robots, also known as vine robots, have attracted growing interest for navigation and inspection tasks, including minimally invasive medical applications [1]. A vine robot consists of a thin, flexible, inextensible tube folded inward that everts and grows forward when pressurized. This tip-growth enables navigation with minimal friction, making vine robots well suited for complex environments such as the human colon [2]. While their inherent softness allows passive conforma- tion to curved pathways in confined spaces, navigation performance strongly depends on environmental inter- actions, including contact angle and the length of un- constrained deployed material [3], [4]. Sharp directional changes, such as those in the sigmoid colon, often limit passive growth and necessitate active steering. Existing solutions include distributed artificial muscles [5] or dedicated tip-based steering mechanisms [6]. In addition, many applications require payload delivery, such as sensors and tools [7], [8]. Within the ERC Synergy project EndoTheranostics, this motivates the development of vine robots capable of delivering micro- surgical tools during growth. Prior work has integrated working channels within the vine body [8], [9], but these approaches constrain tool size, introduce friction, and limit access to the environment to the robot tip. In this work, we propose a multi-vine architecture in which two vine robots are coupled to an externally integrated working channel via soft mounting tips [10]. Independent vine actuation enables active tip steering while advancing the working channel without embed- ding it within the vine bodies Figure 1. Experiments demonstrate sharp steering of nearly 90 degrees during growth, highlighting the potential of this architecture for versatile medical and non-medical applications.

Reliable three-dimensional (3D) navigation of magnetically actuated untethered microrobots remains a major barrier to clinical translation. X-ray fluoroscopy is the standard real-time imaging modality for endovascular procedures, but single-plane fluoroscopy provides only a two-dimensional (2D) projection, eliminating depth information and complicating autonomous navigation. Recovering this information through biplane imaging or repeated contrast-enhanced angiography increases procedural complexity, radiation exposure, or contrast burden. Here, we introduce VISTA (Virtual Integration for Spatial Tracking and Autonomy), a digital twin framework enabling contrast-free autonomous navigation under single-plane fluoroscopy. VISTA reconstructs vascular anatomy as a 3D digital twin, discretizes the vessel centerline into navigation milestones, and assigns the detected 2D robot position to the nearest projected milestone. Consecutive milestones define the local vessel orientation used to generate magnetic actuation commands, converting single-plane fluoroscopic observations into topology-constrained navigation states without requiring contrast injection during navigation. VISTA is demonstrated across anatomically distinct vascular phantoms under continuous flow and within the inferior vena cava of a live rat in vivo. Compared with conventional fluoroscopic human-in-the-loop control, VISTA reduced navigation time by up to 62%, corrective actuation commands by up to 98%, and radiation exposure by up to 57%. These results establish VISTA as a digital twin-guided framework for contrast-free autonomous navigation of untethered endovascular microrobots using widely available single-plane fluoroscopy.

Soft robotic systems are well suited for developing devices for biomedical applications. A bio-mimicking robotic soft esophagus (RoSE) is developed as an in vitro testing device of endoprosthetic stents for dysphagia management. Endoprosthetic stent placement is an immediate and cost-effective therapy for dysphagia caused by malignant esophageal strictures from esophageal cancer. However, later stage complications, like stent migration, could weaken swallow efficacy in the esophagus. The stent radial force (RF) on the esophageal wall is pivotal in avoiding stent migration. Due to limited randomized controlled trials in patients, stent design and stenting guidelines remain incomplete. To address this knowledge deficit, we investigate RoSE by implanting two stents (A and B) of different radial stiffness characteristics, to measure stent RF and its effect on migration. Endoscopic manometry under peristalsis is also performed to study the impact of stenting and stent dysfunction on intra-bolus pressure signatures (IBPSs) and swallowing efficacy. Each implanted stent undergoes experiments with varied peristalsis velocity, wavelength, and bolus concentrations. The results show that stiffer stent B has a higher RF, whereas stent A maintains a lower RF profile due to lesser stiffness. High RF is necessary to minimize migration under prolonged peristaltic contractions in RoSE. For manometry, stent A slightly increases IBPS, but stiffer stent B significantly decreases IBPS, especially for higher-concentration boluses. If a stiffer stent buckles, it can reduce swallow efficacy and cause recurrent dysphagia. RoSE is therefore an innovative soft robotic platform for testing endoprosthetic stents and addressing clinical challenges in stent evaluation.

An endovascular intervention begins with a skilled clinician manually navigating a long, slender wire, called a guidewire, to the target location within the vasculature. Due to factors, such as vessel tortuosity and lack of steerability at the guidewire tip, manual navigation of a guidewire could be challenging, potentially resulting in vessel damage, perforation, dissection, and occlusion, as well as postsurgical complications, such as thrombosis. This work details the development of a handheld actuation mechanism for tendon-driven robotic guidewires by utilizing the aforementioned spooling mechanism. Incorporating the compact spooling mechanism into a handheld device enables clinicians to leverage both motorized guidewire steering and manual rotation and translation, if desired. The proposed device is designed such that, while holding the device, the clinician can execute feeding, rotation, and bending motions for up to 1.5 m of the robotically steerable guidewire using a joystick and momentary switch on the handle. Furthermore, the proposed device is demonstrated through navigation in an anatomically accurate phantom aorta model.

Safe navigation within the spinal subarachnoid space is constrained by its narrow, compliant, and delicate anatomy. Conventional catheters and continuum robots rely on proximal pushing, generating friction and shear along the tissue device interface that limit distal controllability and increase the risk of neural injury. Here, we present a 2 mm diameter eversion-growing robotic platform that enables friction minimised extension and steering within the human spinal subarachnoid space, validated through computational modelling, phantom experiments, and intact human cadaver studies. The robot integrates a miniature endoscope for real time intrathecal visualisation and advances by pressure driven tip eversion, localising motion to the distal tip while minimising translational sliding of the deployed body. Phantom experiments demonstrated reductions of 65.2% in mean interaction force and 48.0% in peak interaction force compared with matched push-based insertion. Physics based modelling showed that eversion based growth redistributed tissue loading, reducing local stress concentrations and interfacial shear relative to conventional insertion. In an intact human cadaver, the system achieved 150 mm of controlled intrathecal extension with concurrent fluoroscopic and endoscopic visualisation, providing access across multiple vertebral levels from a standard lumbar entry point. Postprocedural laminectomy and durotomy revealed no observable macroscopic disruption of the dura mater or surrounding neural structures. These results provide the first mechanically characterised and multimodally validated demonstration of eversion-based robotic navigation in intact human spinal anatomy, establishing a quantitative and procedural foundation for future intrathecal interventions. Further validation in larger anatomical cohorts and under physiological conditions will be required before clinical translation.

Robot-assisted endovascular intervention can potentially reduce radiation exposure, improve surgeon ergonomics, enable telesurgery, support active assistance and autonomy, and enhance procedural precision. However, existing systems often suffer from limited procedural coverage because constrained patient-side setups, restricted flexibility, and complex instrument exchange hinder clinical workflow integration. This work presents a compact robotic system for endovascular interventions that enables continuous translational and rotational manipulation of standard endovascular instruments. The system consists of two alternating carts with pneumatically actuated membrane grippers integrated into rotating gripper gears. Its top-loading design allows rapid exchange of instruments such as guidewires and catheters without changing the robotic setup. A leader-follower control strategy enables continuous motion despite the finite stroke of each cart. The system was evaluated in motion-tracking experiments with guidewires and catheters and in an in vitro vascular phantom. The motion-tracking experiments showed generally smooth translational and rotational motion profiles. Across all tested guidewire and catheter experiments, the mean relative tracking errors were 3.6% for translational motion and 4.1% for rotational motion. In the vascular phantom, robot-assisted navigation reached the target in most trials, demonstrating the feasibility of the proposed manipulation concept under in vitro conditions. The presented robotic system demonstrates technical feasibility for continuous manipulation of standard endovascular instruments in bench-top and in vitro experiments. The compact top-loading design may ease instrument exchange and clinical workflow integration. Future work will focus on improving gripping performance, actuation speed, force feedback, and evaluation in more clinically realistic settings.

Conventional colonoscopy remains limited by patient discomfort and procedural risks, motivating research into compliant robotic alternatives. Eversion robots, which advance via pressure-driven tip growth, eliminate sliding friction against the colon wall and offer a less intrusive approach to traversal. However, no existing design simultaneously satisfies all clinical requirements. This paper benchmarks four recent eversion robot architectures against the key anatomical and clinical constraints of colonoscopy, including colon length, minimum luminal diameter, bending angle, and working-channel needs. We identify the central trade-offs each design reveals, particularly the difficulty of integrating steering and payload delivery without sacrificing the soft, low-friction behaviour that makes eversion robots attractive. We then provide design guidance across material selection, steering strategy, and payload delivery, and highlight open problems for clinical translation.

Mechanical thrombectomy (MT) is a time-critical intervention for acute ischemic stroke; however, access remains limited due to a shortage of neuroradiologists and specialized centers. Reinforcement learning (RL) offers potential to automate endovascular navigation and improve accessibility, yet current models lack standardized frameworks to assess navigation difficulty for model training and evaluation. This study aims to identify vascular metrics associated with navigation difficulty and to develop an automated pipeline for quantitative vascular feature extraction, enabling future complexity grading. Vascular trees were segmented from computed tomography angiograms from 61 patients, and vascular metrics including aortic arch type, presence of bovine arch, vessel length, tortuosity, take-off angle, number of reverse curves, were measured using a custom pipeline. A Soft Actor-Critic RL algorithm was used for 120 s autonomous navigation. Outcomes were analyzed using both mixed effects linear and logistic regression. On the left side, the presence of a bovine arch and aortic arch type II/III increased navigation time by 30.19 s and 37.92 s, respectively, while greater tortuosity (\b{eta} = 118.20) further prolonged the procedure and reduced success probability. On the right side, type II/III arches extended procedure time by 45.94 s, while each additional reverse curve was associated with 3.96 s longer navigation time and lower probability of success. These findings demonstrate for the first time that MT agent navigation difficulty is strongly influenced by vascular geometry. The proposed automated pipeline enables objective and quantitative characterization of vascular features, providing a foundation for future development of standardized complexity grading and RL model evaluation, without aiming to demonstrate clinically generalizable autonomous navigation.

Objective: To evaluate robotic controller interfaces for interventional neuroradiology procedures in-vitro incorporating a force-sensing platform to assess safety. Methods: A custom endovascular robot, device-mimicking controller, and sensorized neurovascular phantom were developed. Ten interventional neuroradiologists (4 novices, 6 experts) performed simulated navigations using four control modalities: device-mimicking controllers with and without haptic feedback, joystick-based input, and manual navigation. Navigation time, peak vessel-wall forces, incorrect catheterisations, and prolapse events were assessed, alongside user analyses. Results: Manual navigation was fastest (mean 47.7 s) compared to haptic-on (248.7 s), haptic-off (314.7 s), and joystick (392.6 s) modalities (p<0.001). Regardless of controller type, vessel-wall forces were below the 0.70 N puncture threshold; therefore all modalities were considered safe. Joystick produced significantly more prolapse events than manual control (1.56 vs 0.13; p=0.018). Operator experience was relevant to performance: experts made fewer incorrect catheterisations than novices (0.25 vs 0.62; p=0.035) and applied less vessel-wall force (p<0.0005); these effects were sustained across controllers but accentuated when haptics were on. Users perceived haptic on and haptic off as similarly intuitive, and more intuitive than joystick (p=0.033). Conclusion: Device-mimicking robotic controllers outperform joystick interfaces on most metrics; haptic feedback shows promising but non-significant performance benefits.

Endovascular interventions are high-stakes procedures requiring precise device operation within complex and tortuous vascular anatomies. Autonomous endovascular navigation has the potential to standardize procedural quality and reduce the performance variability inherent in manual operation. Although Reinforcement Learning (RL) approaches have demonstrated promise in enabling autonomy in endovascular intervention, they often struggle with explicit constraint satisfaction and safety guarantees. To address these challenges, a learning-based expert strategy is introduced, enhancing procedural consistency in autonomous endovascular intervention by explicitly decoupling high-level strategic decision-making from low-level procedural execution. The proposed framework replicates the expert clinical decision-making process: a strategic RL policy generates global navigation intents, which are subsequently refined through an expert-informed execution module. This module ensures that robot movements strictly adhere to expert operational norms, real-time kinematic limits, and vessel safety constraints. Experimental evaluation across high-fidelity 3D simulations and a real-world robotic platform demonstrates that the proposed framework not only outperforms baseline policies but also effectively replicates expert-level proficiency. The framework achieves a high navigation success rate (> 96%) and a 29.3% reduction in operational steps, which translates to enhanced operative efficiency and minimized device-vessel interaction. Furthermore, a 13% reduction in trajectory variance indicates superior procedural standardization, aligning autonomous behavior with established clinical norms. These results underscore its potential to enhance the predictability, safety, and consistency of robotic endovascular interventions.

Robotic-assisted endovascular interventions demand accurate, stable, and context-aware guidewire navigation in complex and patient-specific vascular anatomies. Despite recent advances in robotic precision and learning-based control, existing autonomous navigation methods remain limited by their reliance on static reward functions and the lack of explicit procedural reasoning regarding anatomical context and task progression. To address these challenges, this paper proposes a vision-language procedural reasoning (VL-PR) framework for autonomous guidewire navigation. The framework integrates a multimodal large language model (MLLM) as a procedural reasoning module that interprets real-time visual observations to infer high-level navigation contexts. Instead of generating low-level control commands, the inferred procedural insights enable context-aware reward adaptation by dynamically adjusting the importance of reward components across different navigation phases. This approach allows a single policy to resolve competing objectives and handle complex transitions while preserving a consistent global task goal. Experiments on a physical robotic platform across diverse vascular scenarios demonstrate enhanced task reliability and streamlined navigational efficiency, highlighting the advantages over static-reward methods and offering a scalable solution for complex and multi-task robotic endovascular procedures.

TransEsophageal Echocardiography (TEE) is essential for diagnosing and guiding Structural Heart Disease (SHD) interventions. However, manual TEE manipulation demands significant operator expertise, is physically demanding, and exposes clinicians to radiation when performed alongside fluoroscopy. Robotic-assisted TEE systems have been introduced to improve probe handling and reduce operator fatigue, yet the design of intuitive and effective user interfaces remains an open challenge. This study presents and evaluates a model-enhanced, Augmented Reality (AR)-based intuitive interface for robot-assisted TEE, designed to improve spatial awareness and control intuitiveness. A robotic TEE platform integrated with electromagnetic tracking and a virtual simulator was used to compare three user interfaces differing in visualization and interaction modalities: 2D jointlevel (2D-JI), 3D joint-level (3D-JI), and 3D tip-level (3D-TI). Thirty six participants performed standardized navigation tasks to reproduce target echocardiographic views, with performance assessed via position and orientation errors, completion time, and NASA-TLX workload scores. Results show that 3D visualization significantly improved spatial accuracy, reducing median position error from 13 mm to 3 mm and halving the orientation error compared with the 2D interface. Tip-level interaction yielded a further 50% reduction in orientation error and reduced interuser variability relative to joint-level control. Overall, the 3D-TI configuration, combining immersive visualization with direct tip-level control, proved the most effective and ergonomic interface, supporting the integration of AR-based visualization and intuitive control paradigms into next-generation robotic TEE systems to enhance operator performance and procedural safety.

Coronary guidewire endpoint localization is a fundamental capability for computer-assisted PCI, and its importance increases as robot-assisted PCI is progressively adopted to reduce operator radiation exposure. However, the scarcity of annotated CAG images with guidewires and the limited adaptability of existing guidewire synthesis models remain key bottlenecks for guidewire endpoint localization. To address this issue, we propose VDSB-GWSyn, a Diffusion Schrödinger Bridge (DSB) model-based framework, enabling synthesis of controllable, high-fidelity guidewire samples under complex anatomical backgrounds. VDSB-GWSyn first uses our shape prior algorithm to learn the basic guidewire geometry. It then generates guidewire masks under constraints imposed by the vessel segmentation masks and outputs the corresponding endpoint coordinates. Finally, it synthesizes realistic guidewire samples on real CAG images using DSB conditioned with SPADE. Experimental results show that the guidewire samples synthesized by VDSB-GWSyn achieve favorable ROI-FID and ROI-KID, as well as high IPR scores. In addition, incorporating our synthesized data for synthetic pre-training followed by real fine-tuning substantially improves downstream guidewire endpoint localization, reducing MPE from 16.01px to 7.71px and increasing PCK at 3~px from 52.63% to 86.27%, leading to more clinically reliable deployment of robot-assisted guidewire delivery systems. Moreover, the core design philosophy of controllable device synthesis with strict background preservation and anatomical feasibility constraints has the potential to transfer to other interventional device perception tasks where annotated data are scarce.

Remote robotic-assisted endovascular intervention offers a promising approach to reduce clinician radiation exposure and physical strain, while extending specialized vascular care to geographically distant regions. Despite advancements, teleoperated endovascular intervention remains underexplored, especially for time-sensitive interventions like mechanical thrombectomy for acute stroke. The aim of the current review was to determine the evidence regarding teleoperated endovascular robotic systems, covering technical feasibility, communication infrastructure, and clinical outcomes. The review further identified research gaps and future directions. Following PRISMA guidelines, 16 studies were included that met the inclusion criteria out of 2501 initial search results. We found that teleoperated catheters and guidewires, driven by mechanical or electromagnetic systems, can be navigated across distances up to 7000 km. With robust communication infrastructure, network latency remained within clinically acceptable limits (30-163 ms). Although initial outcomes highlighted 100% procedural success in small-scale human trials, most evidence stemmed from animal or phantom models. Overall, the findings suggest that teleoperated endovascular intervention can reduce occupational hazards, expand patient access to urgent procedures, and optimize resource allocation. Future research should be conducted in low and middle income countries to demonstrate broader geographical access. Ultimately, multi-center clinical trials are required to validate the safety, efficacy, and generalization in diverse clinical settings.

Ultrasound (US)-guided needle insertion is a critical yet challenging procedure due to dynamic imaging conditions and difficulties in needle visualization. Many methods have been proposed for automated needle insertion, but they often rely on hand-crafted pipelines with modular controllers, whose performance degrades in challenging cases. In this paper, a Vision-Language-Action (VLA) model is proposed for adaptive and automated US-guided needle insertion and tracking on a robotic ultrasound (RUS) system. This framework provides a unified approach to needle tracking and needle insertion control, enabling real-time, dynamically adaptive adjustment of insertion based on the obtained needle position and environment awareness. To achieve real-time and end-to-end tracking, a Cross-Depth Fusion (CDF) tracking head is proposed, integrating shallow positional and deep semantic features from the large-scale vision backbone. To adapt the pretrained vision backbone for tracking tasks, a Tracking-Conditioning (TraCon) register is introduced for parameter-efficient feature conditioning. After needle tracking, an uncertainty-aware control policy and an asynchronous VLA pipeline are presented for adaptive needle insertion control, ensuring timely decision-making for improved safety and outcomes. Extensive experiments on both needle tracking and insertion show that our method consistently outperforms state-of-the-art trackers and manual operation, achieving higher tracking accuracy, improved insertion success rates, and reduced procedure time, highlighting promising directions for RUS-based intelligent intervention.

Autonomous mechanical thrombectomy (MT) presents substantial challenges due to highly variable vascular geometries and the requirements for accurate, real-time control. While reinforcement learning (RL) has emerged as a promising paradigm for the automation of endovascular navigation, existing approaches often show limited robustness when faced with diverse patient anatomies or extended navigation horizons. In this work, we investigate a world-model-based framework for autonomous endovascular navigation built on TD-MPC2, a model-based RL method that integrates planning and learned dynamics. We evaluate a TD-MPC2 agent trained on multiple navigation tasks across hold out patient-specific vasculatures and benchmark its performance against the state-of-the-art Soft Actor-Critic (SAC) algorithm agent. Both approaches are further validated in vitro using patient-specific vascular phantoms under fluoroscopic guidance. In simulation, TD-MPC2 demonstrates a significantly higher mean success rate than SAC (58% vs. 36%, p < 0.001), and mean tip contact forces of 0.15 N, well below the proposed 1.5 N vessel rupture threshold. Mean success rates for TD-MPC2 (68%) were comparable to SAC (60%) in vitro, but TD-MPC2 achieved superior path ratios (p = 0.017) at the cost of longer procedure times (p < 0.001). Together, these results provide the first demonstration of autonomous MT navigation validated across both hold out in silico data and fluoroscopy-guided in vitro experiments, highlighting the promise of world models for safe and generalizable AI-assisted endovascular interventions.

Developing generalizable surgical AI requires multi-institutional data, yet privacy constraints preclude direct data sharing, making Federated Learning (FL) a natural candidate. Its application to complex, spatiotemporal surgical video remains largely unbenchmarked. We present the FedSurg Challenge, the first international initiative dedicated to FL in surgical vision, as a proof-of-concept evaluation using a multi-center dataset of laparoscopic appendectomies (subset of Appendix300). Three participant submissions were evaluated on generalization to an unseen clinical center and center-specific local adaptation, alongside centralized, Swarm Learning, parameter-efficient fine-tuning baselines, and reference classifiers. Our analysis identifies temporal modeling as the architectural factor most consistently associated with generalization to the unseen center, although effects vary across metrics. Classifier collapse arises from both the global model's failure to transfer under domain shift and unconstrained fine-tuning on small, imbalanced local datasets, motivating structured personalized FL for center-specific adaptation. Absolute performance remains far from clinical viability: even with all data pooled centrally, the task reached a 26.31% F1-score on the unseen center. Paired permutation tests resolve only large differences, and no adaptation comparison reaches significance at this sample size. By characterizing these limitations, this work establishes a methodological reference point for privacy-preserving surgical video AI.