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Chronic rhinosinusitis (CRS) is a common heterogeneous inflammatory disorder that causes substantial morbidity and healthcare costs. CRS is difficult to identify early from routine encounters, as symptom presentations overlap with common conditions such as allergic rhinitis, and heterogeneous phenotypes further obscure risk patterns. Prior predictive studies often rely on single-institutional cohorts , which reduce population-level generalizability. To overcome this, we leveraged nationwide longitudinal EHR data from the \textit{All of Us} Research Program to predict CRS diagnosis using two years of pre-diagnostic history. To address extreme feature sparsity and dimensionality in coded EHR data, we implemented a hybrid feature-selection pipeline that combines prevalence-based statistical screening with model-based importance ranking, compressing approximately 110,000 candidate codes into 100 interpretable features. To capture demographic heterogeneity, we trained demographic stratified models across six adult sex and life-stage subgroups with subgroup-specific hyperparameter tuning. Our framework achieved an overall AUC of 0.8461, improving discrimination by 0.0168 over the best baseline. These results demonstrate that routinely collected EHR data may support population-representative CRS risk stratification and inform earlier triage and referral prioritization in primary care.

LLM agents operating under organizational policies must comply with authorization constraints typically specified in natural language. In practice, such specifications inevitably contain ambiguities and logical or semantic gaps that cause the agent's behavior to systematically diverge from the true requirements. We ask: by letting an agent evolve its policy understanding through interaction and corrective feedback from pre-deployment testing, can it autonomously refine its interpretation to close specification gaps? We propose PolicyBank, a memory mechanism that maintains structured, tool-level policy insights and iteratively refines them -- unlike existing memory mechanisms that treat the policy as immutable ground truth, reinforcing "compliant but wrong" behaviors. We also contribute a systematic testbed by extending a popular tool-calling benchmark with controlled policy gaps that isolate alignment failures from execution failures. While existing memory mechanisms achieve near-zero success on policy-gap scenarios, PolicyBank closes up to 82% of the gap toward a human oracle.

AI-based systems, currently driven largely by LLMs and tool-using agentic harnesses, are increasingly discussed as a possible threat to software engineering. Foundation models get stronger, agents can plan and act across multiple steps, and tasks such as scaffolding, routine test generation, straightforward bug fixing, and small integration work look more exposed than they did only a few years ago. The result is visible unease not only among students and junior developers, but also among experienced practitioners who worry that hard-won expertise may lose value. This paper argues for a different reading. The important shift is not that software engineering loses relevance. It is that the thing being engineered expands beyond executable code to semi-executable artifacts; combinations of natural language, tools, workflows, control mechanisms, and organizational routines whose enactment depends on human or probabilistic interpretation rather than deterministic execution. The Semi-Executable Stack is introduced as a six-ring diagnostic reference model for reasoning about that expansion, spanning executable artifacts, instructional artifacts, orchestrated execution, controls, operating logic, and societal and institutional fit. The model helps locate where a contribution, bottleneck, or organizational transition primarily sits, and which adjacent rings it depends on. The paper develops the argument through three worked cases, reframes familiar objections as engineering targets rather than reasons to dismiss the transition, and closes with a preserve-versus-purify heuristic for deciding which legacy software engineering processes, controls, and coordination routines should be kept and which should be simplified or redesigned. This paper is a conceptual keynote companion: diagnostic and agenda-setting rather than empirical.

While deep learning systems are becoming increasingly prevalent in medical image analysis, their vulnerabilities to adversarial perturbations raise serious concerns for clinical deployment. These vulnerability evaluations largely rely on Attack Success Rate (ASR), a binary metric that indicates solely whether an attack is successful. However, the ASR metric does not account for other factors, such as perturbation strength, perceptual image quality, and cross-architecture attack transferability, and therefore, the interpretation is incomplete. This gap requires consideration, as complex, large-scale deep learning systems, including Vision Transformers (ViTs), are increasingly challenging the dominance of Convolutional Neural Networks (CNNs). These architectures learn differently, and it is unclear whether a single metric, e.g., ASR, can effectively capture adversarial behavior. To address this, we perform a systematic empirical study on four medical image datasets: PathMNIST, DermaMNIST, RetinaMNIST, and CheXpert. We evaluate seven models (VGG-16, ResNet-50, DenseNet-121, Inception-v3, DeiT, Swin Transformer, and ViT-B/16) against seven attack methods at five perturbation budgets, measuring ASR, Peak Signal-to-Noise Ratio (PSNR), Structural Similarity Index Measure (SSIM), and $L_2$ perturbation magnitude. Our findings show a consistent pattern: perceptual and distortion metrics are strongly associated with one another and exhibit minimal correlation with ASR. This applies to both CNNs and ViTs. The results demonstrate that ASR alone is an inadequate indicator of adversarial robustness and transferability. Consequently, we argue that a thorough assessment of adversarial risk in medical AI necessitates multi-metric frameworks that encompass not only the attack efficacy but also its methodology and associated overheads.

Whether language models can systematically generalize remains actively debated. Yet empirical performance is jointly shaped by multiple factors such as training data, training paradigms, and inference-time strategies, making failures difficult to interpret. We introduce a controlled synthetic environment based on shortest-path planning, a canonical composable sequential optimization problem. The setup enables clean separation of these factors and supports two orthogonal axes of generalization: spatial transfer to unseen maps and length scaling to longer-horizon problems. We find that models exhibit strong spatial transfer but consistently fail under length scaling due to recursive instability. We further analyze how distinct stages of the learning pipeline influence systematic problem-solving: for example, data coverage sets capability limits; reinforcement learning improves training stability but does not expand those limits; and inference-time scaling enhances performance but cannot rescue length-scaling failures.

Artificial Intelligence is increasingly introduced into systems engineering activities, particularly within requirements engineering, where quality assessment and validation remain heavily dependent on expert judgment. While recent AI tools demonstrate promising capabilities in analyzing and generating requirements, their role within formal systems engineering processes-and their alignment with established INCOSE criteria-remains insufficiently understood. This paper investigates the extent to which AI-based tools can support systems engineers in evaluating requirement quality, without replacing professional expertise. The research adopts a structured systems engineering methodology to compare AI-assisted requirement evaluation with human expert assessment. A controlled study was conducted in which system requirements were evaluated against established INCOSE ``good requirement'' criteria by both experienced systems engineers and an AI-based assessment tool. The evaluation focused on consistency, completeness, clarity, and testability, examining not only accuracy but also the decision logic underlying each assessment. Results indicate that AI tools can provide consistent and rapid preliminary assessments, particularly for syntactic and structural quality attributes. However, expert judgment remains essential for contextual interpretation, ambiguity resolution, and trade-off reasoning. Rather than positioning AI as a replacement for systems engineers, the findings support its role as a decision-support mechanism within the RE lifecycle. From a systems engineering perspective, this study contributes empirical evidence on how AI can be integrated into RE workflows while preserving traceability, accountability, and engineering consistency.

Simulating group-level user behavior enables scalable counterfactual evaluation of merchant strategies without costly online experiments. However, building a trustworthy simulator faces two structural challenges. First, information incompleteness causes reasoning-based simulators to over-rationalize when unobserved factors such as offline context and implicit habits are missing. Second, mechanism duality requires capturing both interpretable preferences and implicit statistical regularities, which no single paradigm achieves alone. We propose Policy-Guided Hybrid Simulation (PGHS), a dual-process framework that mines transferable decision policies from behavioral trajectories and uses them as a shared alignment layer. This layer anchors an LLM-based reasoning branch that prevents over-rationalization and an ML-based fitting branch that absorbs implicit regularities. Group-level predictions from both branches are fused for complementary correction. We deploy PGHS on Meituan with 101 merchants and over 26,000 trajectories. PGHS achieves a group simulation error of 8.80%, improving over the best reasoning-based and fitting-based baselines by 45.8% and 40.9% respectively.

LLM-based coding agents can generate functionally correct GPU kernels, yet their performance remains far below hand-optimized libraries on critical computations such as matrix multiplication, attention, and Mixture-of-Experts (MoE). Peak GPU performance requires coordinated reasoning over tightly coupled optimizations, including tiling, shared-memory staging, software pipelining, and instruction scheduling, while existing agents rely on sparse pass/fail feedback, leaving them unable to diagnose global constraint violations. We present Argus, an agentic framework that addresses this through data-flow invariants: compile-time specifications encoding how data must be choreographed throughout kernel execution. Argus introduces a tile-based, Pythonic DSL exposing hardware instructions and compiler policies while hiding low-level representations. The DSL provides tag functions to propagate symbolic annotations through data and control flow, and tag assertions to enforce relational constraints at use sites. When violations occur, the compiler returns concrete counterexamples identifying the thread, data element, and program point, enabling dense, structured feedback for targeted fixes. Invariants are verified at compile time via abstract interpretation over a layout algebra and SMT solving, with zero runtime overhead. An in-context reinforcement learning planner learns to select optimizations and synthesize effective invariants, supported by a curated knowledge base of GPU optimization techniques. We evaluate Argus on the AMD MI300X GPU across GEMM, flash attention, and MoE kernels accounting for over 90% of GPU time in LLM inference. Generated kernels achieve 99-104% of state-of-the-art hand-optimized assembly throughput and are 2-1543x faster than existing agentic systems. Argus further generalizes to 200 KernelBench tasks, solving 100% of Level 1 and 90% of Level 2 problems.

Continuous glucose monitoring (CGM) is central to diabetes care, but explaining CGM patterns clearly and empathetically remains time-intensive. Evidence for retrieval-grounded large language model (LLM) systems in CGM-informed counseling remains limited. To evaluate whether a retrieval-grounded LLM-based conversational agent (CA) could support patient understanding of CGM data and preparation for routine diabetes consultations. We developed a retrieval-grounded LLM-based CA for CGM interpretation and diabetes counseling support. The system generated plain-language responses while avoiding individualized therapeutic advice. Twelve CGM-informed cases were constructed from publicly available datasets. Between Oct 2025 and Feb 2026, 6 senior UK diabetes clinicians each reviewed 2 assigned cases and answered 24 questions. In a blinded multi-rater evaluation, each CA-generated and clinician-authored response was independently rated by 3 clinicians on 6 quality dimensions. Safety flags and perceived source labels were also recorded. Primary analyses used linear mixed-effects models. A total of 288 unique responses (144 CA and 144 clinician) generated 864 ratings. The CA received higher quality scores than clinician responses (mean 4.37 vs 3.58), with an estimated mean difference of 0.782 points (95% CI 0.692-0.872; P<.001). The largest differences were for empathy (1.062, 95% CI 0.948-1.177) and actionability (0.992, 95% CI 0.877-1.106). Safety flag distributions were similar, with major concerns rare in both groups (3/432, 0.7% each). Retrieval-grounded LLM systems may have value as adjunct tools for CGM review, patient education, and preconsultation preparation. However, these findings do not support autonomous therapeutic decision-making or unsupervised real-world use.

Transformer-based detectors have advanced small-object detection, but they often remain inefficient and vulnerable to background-induced query noise, which motivates deep decoders to refine low-quality queries. We present HELP (Heatmap-guided Embedding Learning Paradigm), a noise-aware positional-semantic fusion framework that studies where to embed positional information by selectively preserving positional encodings in foreground-salient regions while suppressing background clutter. Within HELP, we introduce Heatmap-guided Positional Embedding (HPE) as the core embedding mechanism and visualize it with a heatbar for interpretable diagnosis and fine-tuning. HPE is integrated into both the encoder and decoder: it guides noise-suppressed feature encoding by injecting heatmap-aware positional encoding, and it enables high-quality query retrieval by filtering background-dominant embeddings via a gradient-based mask filter before decoding. To address feature sparsity in complex small targets, we integrate Linear-Snake Convolution to enrich retrieval-relevant representations. The gradient-based heatmap supervision is used during training only, incurring no additional gradient computation at inference. As a result, our design reduces decoder layers from eight to three and achieves a 59.4% parameter reduction (66.3M vs. 163M) while maintaining consistent accuracy gains under a reduced compute budget across benchmarks. Code Repository: https://github.com/yidimopozhibai/Noise-Suppressed-Query-Retrieval

Recent advances in large language models (LLMs) have sparked growing interest in automatic RTL optimization for better performance, power, and area (PPA). However, existing methods are still far from realistic RTL optimization. Their evaluation settings are often unrealistic: they are tested on manually degraded, small-scale RTL designs and rely on weak open-source tools. Their optimization methods are also limited, relying on coarse design-level feedback and simple pre-defined rewriting rules. To address these limitations, we present Dr. RTL, an agentic framework for RTL timing optimization in a realistic evaluation environment, with continual self-improvement through reusable optimization skills. We establish a realistic evaluation setting with more challenging RTL designs and an industrial EDA workflow. Within this setting, Dr. RTL performs closed-loop optimization through a multi-agent framework for critical-path analysis, parallel RTL rewriting, and tool-based evaluation. We further introduce group-relative skill learning, which compares parallel RTL rewrites and distills the optimization experience into an interpretable skill library. Currently, this library contains 47 pattern--strategy entries for cross-design reuse to improve PPA and accelerate convergence, and it can continue evolving over time. Evaluated on 20 real-world RTL designs, Dr. RTL achieves average WNS/TNS improvements of 21%/17% with a 6% area reduction over the industry-leading commercial synthesis tool.

Tool learning with foundation models aims to endow AI systems with the ability to invoke external resources -- such as APIs, computational utilities, and specialized models -- to solve complex tasks beyond the reach of standalone language generation. While recent advances in Large Language Models (LLMs) and Multimodal Large Language Models (MLLMs) have expanded their reasoning and perception capabilities, existing tool-use methods are predominantly limited to text-only inputs and closed-world settings. Consequently, they struggle to interpret multimodal user instructions and cannot generalize to tools unseen during training. In this work, we introduce RaTA-Tool, a novel framework for open-world multimodal tool selection. Rather than learning direct mappings from user queries to fixed tool identifiers, our approach enables an MLLM to convert a multimodal query into a structured task description and subsequently retrieve the most appropriate tool by matching this representation against semantically rich, machine-readable tool descriptions. This retrieval-based formulation naturally supports extensibility to new tools without retraining. To further improve alignment between task descriptions and tool selection, we incorporate a preference-based optimization stage using Direct Preference Optimization (DPO). To support research in this setting, we also introduce the first dataset for open-world multimodal tool use, featuring standardized tool descriptions derived from Hugging Face model cards. Extensive experiments demonstrate that our approach significantly improves tool-selection performance, particularly in open-world, multimodal scenarios.

Generative Agents, owing to their precise modeling and simulation capabilities of human behavior, have become a pivotal tool in the field of Artificial Intelligence in Education (AIEd) for uncovering complex cognitive processes of learners. However, existing educational agents predominantly rely on static personas to simulate student learning behaviors, neglecting the decisive role of deep cognitive capabilities in learning outcomes during practice interactions. Furthermore, they struggle to characterize the dynamic fluidity of knowledge internalization, transfer, and cognitive state transitions. To overcome this bottleneck, this paper proposes a human-like educational agent capable of simulating student cognitive evolution: CogEvolution. Specifically, we first construct a cognitive depth perceptron based on the Interactive, Constructive, Active, Passive (ICAP) taxonomy from cognitive psychology, achieving precise quantification of learner cognitive engagement. Subsequently, we propose a memory retrieval method based on Item Response Theory (IRT) to simulate the connection and assimilation of new and prior knowledge. Finally, we design a dynamic cognitive update mechanism based on evolutionary algorithms to simulate the real-time integration of student learning behaviors and cognitive evolution processes. Comprehensive evaluations demonstrate that CogEvolution not only significantly outperforms baseline models in behavioral fidelity and learning curve fitting but also uniquely reproduces plausible and robust cognitive evolutionary paths consistent with educational psychology expectations, providing a novel paradigm for constructing highly interpretable educational agents.

Online anomaly detection (OAD) plays a pivotal role in real-time analytics and decision-making for evolving data streams. However, existing methods often rely on costly retraining and rigid decision boundaries, limiting their ability to adapt both effectively and efficiently to concept drift in dynamic environments. To address these challenges, we propose DyMETER, a dynamic concept adaptation framework for OAD that unifies on-the-fly parameter shifting and dynamic thresholding within a single online paradigm. DyMETER first learns a static detector on historical data to capture recurring central concepts, and then transitions to a dynamic mode to adapt to new concepts as drift occurs. Specifically, DyMETER employs a novel dynamic concept adaptation mechanism that leverages a hypernetwork to generate instance-aware parameter shifts for the static detector, thereby enabling efficient and effective adaptation without retraining or fine-tuning. To achieve robust and interpretable adaptation, DyMETER introduces a lightweight evolution controller to estimate instance-level concept uncertainty for adaptive updates. Further, DyMETER employs a dynamic threshold optimization module to adaptively recalibrates the decision boundary by maintaining a candidate window of uncertain samples, which ensures continuous alignment with evolving concepts. Extensive experiments demonstrate that DyMETER significantly outperforms existing OAD approaches across a wide spectrum of application scenarios.

Large language models are increasingly used as natural-language interfaces to enterprise software, but their direct use as system operators remains unsafe. Model errors can propagate into unauthorized actions, malformed requests, cross-workspace execution, and other costly failures. We argue this is primarily an execution architecture problem. We present a bounded-autonomy architecture in which language models may interpret intent and propose actions, but all executable behavior is constrained by typed action contracts, permission-aware capability exposure, scoped context, validation before side effects, consumer-side execution boundaries, and optional human approval. The enterprise application remains the source of truth for business logic and authorization, while the orchestration engine operates over an explicit published actions manifest. We evaluate the architecture in a deployed multi-tenant enterprise application across three conditions: manual operation, unconstrained AI with safety layers disabled, and full bounded autonomy. Across 25 scenario trials spanning seven failure families, the bounded-autonomy system completed 23 of 25 tasks with zero unsafe executions, while the unconstrained configuration completed only 17 of 25. Two wrong-entity mutations escaped all consumer-contributed layers; only disambiguation and confirmation mechanisms intercept this class. Both AI conditions delivered 13-18x speedup over manual operation. Critically, removing safety layers made the system less useful: structured validation feedback guided the model to correct outcomes in fewer turns, while the unconstrained system hallucinated success. Several safety properties are structurally enforced by code and intercepted all targeted violations regardless of model output. The result is a practical, deployed architecture for making imperfect language models operationally useful in enterprise systems.

Video understanding requires identifying and reasoning over semantically discriminative visual objects across frames, yet existing object-agnostic solutions struggle to effectively handle substantial object variations over time. To address this, we introduce Chain-of-Glimpse, a search-guided progressive object-grounded reasoning framework that explicitly anchors each reasoning step to specific visual evidence regions, enabling compositional and multi-step decision-making. Formally, Chain-of-Glimpse formulates video reasoning as a step-by-step process that incrementally builds spatially grounded traces around task-relevant visual objects, thereby mitigating over-reliance on saliency-driven cues. Specifically, Chain-of-Glimpse features a search-guided controller, optimized via reinforcement learning with a format reward that significantly incentivizes grounding capability, to iteratively ground visual evidence regions and form reliable reasoning trajectories, yielding accurate and interpretable multi-step decisions. Extensive evaluations on both in domain NExTQA and out-of-domain Video-Holmes, CG-Bench Reasoning, and VRBench benchmarks demonstrate consistent performance gains, robustness and generalization of Chain-of-Glimpse across diverse video reasoning tasks.

LLM-empowered agent simulations are increasingly used to study social emergence, yet the micro-to-macro causal mechanisms behind macro outcomes often remain unclear. This is challenging because emergence arises from intertwined agent interactions and meso-level feedback and nonlinearity, making generative mechanisms hard to disentangle. To this end, we introduce \textbf{\textsc{CAMO}}, an automated \textbf{Ca}usal discovery framework from \textbf{M}icr\textbf{o} behaviors to \textbf{M}acr\textbf{o} Emergence in LLM agent simulations. \textsc{CAMO} converts mechanistic hypotheses into computable factors grounded in simulation records and learns a compact causal representation centered on an emergent target $Y$. \textsc{CAMO} outputs a computable Markov boundary and a minimal upstream explanatory subgraph, yielding interpretable causal chains and actionable intervention levers. It also uses simulator-internal counterfactual probing to orient ambiguous edges and revise hypotheses when evidence contradicts the current view. Experiments across four emergent settings demonstrate the promise of \textsc{CAMO}.

Monte-Carlo Tree Search (MCTS) is a fundamental sampling-based search algorithm widely used for online planning in sequential decision-making domains. Despite its success in driving recent advances in artificial intelligence, understanding the behavior of MCTS agents remains a challenge for both developers and users. This difficulty stems from the complex search trees produced through the simulation of numerous future states and their intricate relationships. A known weakness of standard MCTS is its reliance on highly selective tree construction, which may lead to the omission of crucial moves and a vulnerability to tactical traps. To resolve this, we incorporate shallow, full-width Minimax search into the rollout phase of multi-agent MCTS to enhance strategic depth. Furthermore, to demystify the resulting decision-making logic, we introduce \textsf{M2-PALE} (MCTS--Minimax Process-Aided Linguistic Explanations). This framework employs process mining techniques, specifically the Alpha Miner, iDHM, and Inductive Miner algorithms, to extract underlying behavioral workflows from agent execution traces. These process models are then synthesized by LLMs to generate human-readable causal and distal explanations. We demonstrate the efficacy of our approach in a small-scale checkers environment, establishing a scalable foundation for interpreting hybrid agents in increasingly complex strategic domains.

Clinical language models (LMs) are increasingly applied to support clinical risk prediction from free-text notes, yet their uncertainty estimates often remain poorly calibrated and clinically unreliable. In this work, we propose Clinical Uncertainty Risk Alignment (CURA), a framework that aligns clinical LM-based risk estimates and uncertainty with both individual error likelihoods and cohort-level ambiguities. CURA first fine-tunes domain-specific clinical LMs to obtain task-adapted patient embeddings, and then performs uncertainty fine-tuning of a multi-head classifier using a bi-level uncertainty objective. Specifically, an individual-level calibration term aligns predictive uncertainty with each patient's likelihood of error, while a cohort-aware regularizer pulls risk estimates toward event rates in their local neighborhoods in the embedding space and places extra weight on ambiguous cohorts near the decision boundary. We further show that this cohort-aware term can be interpreted as a cross-entropy loss with neighborhood-informed soft labels, providing a label-smoothing view of our method. Extensive experiments on MIMIC-IV clinical risk prediction tasks across various clinical LMs show that CURA consistently improves calibration metrics without substantially compromising discrimination. Further analysis illustrates that CURA reduces overconfident false reassurance and yields more trustworthy uncertainty estimates for downstream clinical decision support.

When faced with complex spatial problems, humans naturally sketch layouts to organize their thinking, and the act of drawing further sharpens their understanding. In this work, we ask whether a similar principle holds for Large Language Models (LLMs): can learning to construct explicit visual layouts from spatial descriptions instill genuine spatial understanding? We introduce Text2Space, a dataset that pairs natural language descriptions with ground-truth ASCII grid layouts and spatial QA pairs, enabling us to separate failures in constructing spatial representations from failures in reasoning over them. We adopt ASCII because it is human-readable, operates entirely within the token space of language models, and encodes spatial relations in a structurally verifiable form. Our evaluation reveals a pronounced "Read-Write Asymmetry": LLMs interpret ASCII representations effectively but struggle to produce them from text, and these construction errors propagate to incorrect answers downstream. To address this limitation, we train models on layout construction (Text$\rightarrow$ASCII) and find that it significantly improves spatial reasoning from text alone, even without producing any ASCII at inference time. Combining construction with comprehension training further amplifies these gains. Crucially, these improvements transfer to three external spatial reasoning benchmarks, demonstrating that, much as sketching sharpens human spatial thinking, learning to construct explicit layouts instills spatial understanding that generalizes beyond the training format.

Wearable devices generate continuous physiological and behavioral data, but converting these signals into clinically reviewable biomarker hypotheses remains labor-intensive. We introduce CoDaS, an AI co-data-scientist that integrates multi-agent hypothesis generation, deterministic statistical analysis, adversarial validation and literature-grounded interpretation under human oversight. Across three wearable cohorts comprising 9,279 participant-observations, CoDaS prioritized candidate associations for mental-health and metabolic endpoints after internal checks for replication, stability, robustness and leakage. The system identified related circadian-instability signals associated with depression, including sleep-duration variability in DWB ($ρ$ = 0.252, $p$ < 0.001) and sleep-onset variability in GLOBEM ($ρ$ = 0.126, $p$ < 0.001), and derived a wearable cardiovascular-fitness index associated with insulin resistance (steps/resting heart rate; $ρ$ = -0.374, $p$ < 0.001). Adding these features to demographic models produced modest gains ($ΔR^2$ = 0.040 for depression, 0.021 for insulin resistance). In a 12-clinician review totaling approximately 25 active hours, clinician validity judgments aligned with CoDaS confidence tiers ($ρ$ = 0.67, $p$ = 0.005), whereas added clinical value and confidence to act were rated lower. CoDaS supports traceable, hypothesis-generating prioritization of wearable candidate biomarkers.

While Large Language Models (LLMs) demonstrate increasingly sophisticated affective capabilities, the internal mechanisms by which they process complex emotions remain unclear. Existing interpretability approaches often treat models as black boxes or focus on coarse-grained basic emotions, leaving the cognitive structure of more complex affective states underexplored. To bridge this gap, we propose a Cognitive Reverse-Engineering framework based on Representation Engineering (RepE) to analyze social-comparison jealousy. By combining appraisal theory with subspace orthogonalization, regression-based weighting, and bidirectional causal steering, we isolate and quantify two psychological antecedents of jealousy, Superiority of Comparison Person and Domain Self-Definitional Relevance, and examine their causal effects on model judgments. Experiments on eight LLMs from the Llama, Qwen, and Gemma families suggest that models natively encode jealousy as a structured linear combination of these constituent factors. Their internal representations are broadly consistent with the human psychological construct, treating Superiority as the foundational trigger and Relevance as the ultimate intensity multiplier. Our framework also demonstrates that toxic emotional states can be mechanically detected and surgically suppressed, suggesting a possible route toward representational monitoring and intervention for AI safety in multi-agent environments.

Every call to an LLM classification endpoint produces a labeled input-output pair already retained in production logs. These pairs constitute a free, growing training set: a lightweight surrogate trained on them can absorb a significant portion of future traffic at near-zero marginal inference cost. The open questions are when the surrogate is reliable enough to deploy, what it handles versus defers, and how that boundary evolves as data accumulates. We introduce TRACER (Trace-based Adaptive Cost-Efficient Routing), an open-source system that trains ML surrogates on an LLM's own production traces and governs deployment through a parity gate: the surrogate is activated only when its agreement with the LLM exceeds a user-specified threshold α. To make the routing boundary transparent, TRACER generates interpretability artifacts describing which input regions the surrogate handles, where it plateaus, and why it defers. On a 77-class intent benchmark with a Sonnet 4.6 teacher, TRACER achieves 83-100% surrogate coverage depending on the quality target α; on a 150-class benchmark, the surrogate fully replaces the teacher. On a natural language inference task, the parity gate correctly refuses deployment because the embedding representation cannot support reliable separation. The system is available as open-source software.

Professional fact-checkers rely on domain knowledge and deep contextual understanding to verify claims. Large language models (LLMs) and large reasoning models (LRMs) lack such grounding and primarily reason from available evidence alone, creating a mismatch between expert-led and fully automated claim verification. To mitigate this gap, we posit human-AI collaboration as a more promising path forward, where expert feedback, grounded in real-world knowledge and domain expertise, guides the model's reasoning. However, existing LRMs are hard to calibrate to natural language feedback, particularly in a multi-turn interaction setup. We propose Co-FactChecker, a framework for human-AI collaborative claim verification. We introduce a new interaction paradigm that treats the model's thinking trace as a shared scratchpad. Co-FactChecker translates expert feedback into trace-edits that introduce targeted modifications to the trace, sidestepping the shortcomings of dialogue-based interaction. We provide theoretical results showing that trace-editing offers advantages over multi-turn dialogue, and our automatic evaluations demonstrate that Co-FactChecker outperforms existing autonomous and human-AI collaboration approaches. Human evaluations further show that Co-FactChecker is preferred over multi-turn dialogue, producing higher quality reasoning and verdicts along with relatively easier to interpret and more useful thinking traces.

Generative diffusion models have emerged as powerful tools for the discovery of inorganic crystal structures, yet steering their sampling process toward user-defined physical and chemical objectives remains challenging. We present a computational framework that integrates adaptive constraint guidance into a pre-trained crystal diffusion model, enabling the generation of candidate structures that satisfy targeted structural and chemical requirements without model retraining. The approach incorporates differentiable constraint functions directly during sampling, providing an interpretable mechanism for expert-driven exploration of the crystal structure space. To assess the reliability of generated candidates, we introduce a multi-stage validation workflow combining descriptor-based analysis, duplicate removal, comparison with reference crystal databases, graph neural network energy prediction, and thermodynamic stability evaluation through convex-hull analysis. The framework is applied to several classes of inorganic compounds and to constraints involving atomic volume, local coordination environments, and near-neighbor structural motifs. Results demonstrate that adaptive guidance effectively redirects the sampling distribution toward structures exhibiting the desired characteristics while preserving chemical plausibility. Subsequent validation reveals which generated candidates remain viable after energetic and thermodynamic screening. The proposed methodology provides a practical and transparent strategy for incorporating expert knowledge into crystal generative models and establishes a general computational framework for constrained materials discovery.

Reliable image quality assessment is essential in applications where large volumes of images are acquired automatically and must be filtered before further analysis. In many practical scenarios, a pristine reference image is unavailable, making no reference image quality assessment (NR-IQA) particularly important. This paper introduces Multi-Metric Image Quality Assessment (MM-IQA), a lightweight multi-metric framework for NR-IQA. It combines interpretable cues related to blur, edge structure, low resolution artifacts, exposure imbalance, noise, haze, and frequency content to produce a single quality score in the range [0,100].MM-IQA was evaluated on five benchmark datasets (KonIQ-10k, LIVE Challenge, KADID-10k, TID2013, and BIQ2021) and achieved SRCC values ranging from 0.647 to 0.830. Additional experiments on a synthetic agricultural dataset showed consistent behavior of the designed cues. The Python/OpenCV implementation required about 1.97 s per image. This method also has modest memory requirements because it stores only a limited number of intermediate grayscale, filtered, and frequency-domain representations, resulting in memory usage that scales linearly with image size. The results show that MM-IQA can be used for fast image quality screening with explicit distortion aware cues and modest computational cost.

Mechanistic understanding and rational design of complex chemical systems depend on fast and accurate predictions of electronic structures beyond individual building blocks. However, if the system exceeds hundreds of atoms, first-principles quantum mechanical (QM) modeling becomes impractical. In this study, we developed FB-GNN-MBE by integrating a fragment-based graph neural network (FB-GNN) into the many-body expansion (MBE) theory and demonstrated its capacity to reproduce first-principles potential energy surfaces (PES) for hierarchically structured systems with manageable accuracy, complexity, and interpretability. Specifically, we divided the entire system into basic building blocks (fragments), evaluated their one-fragment energies using a QM model, and addressed many-fragment interactions using the structure-property relationships trained by FB-GNNs. Our investigation shows that FB-GNN-MBE achieves chemical accuracy in predicting two-body (2B) and three-body (3B) energies across water, phenol, and mixture benchmarks, as well as the one-dimensional dissociation curves of water and phenol dimers. To transfer the success of FB-GNN-MBE across various systems with minimal computational costs and data demands, we developed and validated a teacher-student learning protocol. A heavy-weight FB-GNN trained on a mixed-density water cluster ensemble (teacher) distills its learned knowledge and passes it to a light-weight GNN (student), which is later fine-tuned on a uniform-density (H2O)21 cluster ensemble. This transfer learning strategy resulted in efficient and accurate prediction of 2B and 3B energies for variously sized water clusters without retraining. Our transferable FB-GNN-MBE framework outperformed conventional non-FB-GNN-based models and provided a scalable and accurate route toward interaction energies of large molecular assemblies.

Augmentation has become a central technique for improving deep forecasting models, but classification-style transformations tend to break the coherence between the look-back window and its continuous future target. We describe a simple procedure that unfolds the joint input-target sequence into overlapping sliding windows, randomly reorders a controlled fraction of them-prioritized by a lightweight variance criterion-and reconstructs the sequence by averaging across the overlaps, producing synthetic samples with controlled variation while limiting temporal distortion. The procedure is model-agnostic, introduces only three interpretable hyperparameters, and achieves strong improvements over a comprehensive set of competing augmentations across nine long-term forecasting benchmarks with five backbone families (TSMixer, DLinear, PatchTST, TiDE, LightTS) and four short-term traffic benchmarks with PatchTST. Component-wise ablations, hyperparameter sensitivity studies, distributional-alignment diagnostics, probabilistic forecasting evaluation, and a transfer experiment to univariate and multivariate time series classification clarify the contribution of each design choice.

These lecture notes provide a comprehensive framework for performing global statistical fits in high-energy physics using modern Machine Learning (ML) surrogates. We begin by reviewing the statistical foundations of model building, including the likelihood function, Wilks' theorem, and profile likelihoods. Recognizing that the computational cost of evaluating model predictions often renders traditional minimization prohibitive, we introduce Boosted Decision Trees to approximate the log-likelihood function. The notes detail a robust ML workflow including efficient generation of training data with active learning and Gaussian processes, hyperparameter optimization, model compilation for speed-up, and interpretability through SHAP values to decode the influence of model parameters and interactions between parameters. We further discuss posterior distribution sampling using Markov Chain Monte Carlo (MCMC). These techniques are finally applied to the $B^\pm \to K^\pm ν\barν$ anomaly at Belle II, demonstrating how a two-stage ML model can efficiently explore the parameter space of Axion-Like Particles (ALPs) while satisfying stringent experimental constraints on decay lengths and flavor-violating couplings.

Vision-Language Models often struggle with complex visual reasoning due to the visual information loss in textual CoT. Existing methods either add the cost of tool calls or rely on localized patch-based embeddings that are insufficient to extract semantics in multi-step reasoning. We propose "Decompose, Look, and Reason" (DLR), a reinforced latent reasoning framework that dynamically decomposes queries into textual premises, extracts premise-conditioned continuous visual latents, and deduces answers through grounded rationales. We introduce a three-stage training pipeline and propose a novel Spherical Gaussian Latent Policy, to enable effective exploration in the latent space. Extensive experiments on vision-centric benchmarks show that DLR consistently outperforms strong baselines, including text-only, interleaved multimodal CoT, and latent reasoning methods, while providing superior stepwise interpretability.