Oct 27, 2026J/K move · Enter open · S save
Humza Nusrat, Kundan Thind
Department of Radiation Oncology, Henry Ford Health, Detroit, Michigan, USA · Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA
Background and purpose: Radiotherapy planning agents based on large language models (LLMs) decide when to submit a plan or request review but are evaluated mainly by dose. This study developed OpenGray, a benchmark of planning tasks with known correct decisions. Materials and methods: OpenGray adds tasks with known answers to the OpenKBP-Opt head-and-neck dataset, including two contradictions with dose goals proven incompatible and a feasible control with a stored plan meeting every hard goal. Four systems, from a rule-based planning script to a full LLM agent, were evaluated on 30 patients, the LLM-based ones with a commercial (Terra) and a local (Ministral 3 8B) LLM. Decisions, achieved dose, problem recognition, and technical failures were recorded and also read from logs of 39 stereotactic radiosurgery runs of SAGE, a clinical LLM agent. Results: With Terra, the script preceded by an LLM review and the full agent had decision accuracies of 95.4% and 92.1%, respectively, yet escalated only 50% (95% confidence interval, 25-75%) and 25% (10-40%) of overlap contradictions, which required arithmetic on the anatomy. All four systems submitted every feasible control, but 24% of these plans missed a hard goal that the stored plan had met. In four SAGE runs, one goal failed at every attempt; the agent identified it in every reply but had no action for stopping. Conclusions: Favorable aggregate scores concealed specific decision failures. Planning agents should be evaluated on their decisions as well as their dose and given an explicit action for stopping and requesting review.