Robotic Laboratory Automation

Latest papers

14 papers4 papers in the last four weeks, against 2 the four weeks before. 0.0% of all new papers.

Nov 3, 2026

Embodied AI for Scientific Discovery: From Physical Action to Scientific Evidence

Scientific experiments are increasingly selected, executed and interpreted by learned systems that act through physical interfaces. Robot learning builds physical competence, whereas AI for science chooses which experiment to run, each reporting different endpoints. This review treats their interface as one problem, embodied AI for science, where the experiment itself is partially observed: specimen state, apparatus state and measurement processes are latent, actions are costly and irreversible, and missingness depends on execution and outcome. We organize the literature by three closures operating at distinct levels: operational closure (the experiment realized is the one intended), epistemic closure (the result updates beliefs or selects subsequent experiments) and evidential closure (the record supports a claim). We analyze workflows through a record-linked evidence cycle - Record, Diagnose, Calibrate, Confirm - as analytic functions with feedback. A taxonomy crosses these closures with six delegated decisions and five embodiment classes. Our formulation separates commanded, realized and observed conditions and models diagnosis with explicit resource, risk and sample-change costs. We compare experiment-selection methods by terminal decision, review perception, protocol compilation, visuomotor policies, world models, recovery and transfer by evidence emission requirements, and compare chemistry, materials, biology, microscopy and field workflows by what their records establish. An appendix provides an evidence map of 28 workflows (26 physical, two software-boundary), characterizing validation pathways and claim confirmation requirements. We propose evaluation that separates actions, valid experiments, campaigns and confirmed claims, framing open challenges as controlled comparisons with measurable failure conditions.

Wenhao Xu, Changwei Wang, Shunpeng Chen +6

Zhengzhou Police University, Zhengzhou, China · Qilu University of Technology (Shandong Academy of Sciences) and Shandong Computer Science Center, Jinan, China · School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China +4

AI for Science Autonomous Experimentation Robotic Laboratory Automation Scientific Claim Verification

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Oct 30, 2026

BioAgent: Self-Directed Skill Acquisition and Capability Growth for Long-Horizon Laboratory Protocols

Executing an unfamiliar laboratory protocol requires a robot to identify missing capabilities and determine whether each operation remains valid as the experiment progresses. This letter presents BioAgent, an embodied agent that addresses these coupled challenges of capability sufficiency and experimental validity. It matches human-reviewed requirements to validated skills and task packages, selects tool-based implementations for missing behaviors, and requests human teaching when needed during learning. Learned skills undergo sequential task-package validation to check outcomes and compatibility between successive operations. During execution, precondition, outcome, and experimental-state checks govern progression, autonomous recovery, or termination. Execution evidence guides tool selection, while accepted experience supports offline policy updates and task packaging. On the second task, BioAgent reuses 17 skill types unchanged, revises two existing implementations, and acquires five new types. On two dual-arm laboratory tasks with 20 and 31 ordered skill invocations, BioAgent achieves complete-task success rates of 66% and 58% with autonomous recovery over 50 runs per task. Across 25 atomic skills evaluated over 50 autonomous trials each with recovery disabled, success rates range from 84% to 100%, with 17 skills achieving 50/50.

Gaojing Zhang, Changwen Chen, Zichen Luo +4

Shanghai Jiao Tong University · University of Sussex

Robotic Laboratory Automation Robotics Robot Skill Learning Agent Skill Learning Long-Horizon Robotic Manipulation Continual Robot Learning

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Oct 26, 2026

Labference: Benchmarking the Reasoning-Action Connection in Robotic Laboratories

Realizing Embodied AI for Science requires robots to translate experimental goals into reliable physical procedures, reducing hazardous and repetitive human work while generating evidence for scientific discovery. Although language-based planning and learned manipulation provide complementary capabilities, their integration requires robots to adapt subsequent operations to actual execution outcomes. For example, an unsuccessful placement changes what must be done next, even when the experimental goal remains unchanged. Existing benchmarks assess planning, manipulation, and laboratory workflows through task completion and reasoning or execution metrics; however, aggregate performance leaves the connection between outcome-dependent choices and physical execution unresolved. To address this evaluation gap, we introduce Labference, a benchmark for evaluating how observed physical outcomes guide subsequent choices and how those choices translate into robotic laboratory actions. Its evaluation protocol is designed to test outcome-dependent behavioral adaptation through controlled evidence variations, while independently measuring operation selection, physical execution, and task completion. Matched Oracle-assisted continuations from shared checkpoints then assess which forms of support improve subsequent choices and task completion. Initial weighing evaluations reveal target-selection errors in the tested VLA policies despite successful object transfers, whereas GPT-driven control achieves correct selection but encounters execution failures and substantial computation costs. Together, these findings highlight the need to connect task-appropriate reasoning with reliable, timely action. By making this connection measurable and diagnosable, Labference supports targeted improvements toward autonomous experimentation for Embodied AI for Science.

Shitong Liu, Xu Yang, Jingwei Zhang +18

Robotic Laboratory Automation Robotics Embodied Agent Benchmarks Robot Manipulation Benchmarks Autonomous Experimentation Robot Task Planning

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Oct 16, 2026

Self-Building Labs

Self-driving laboratories (SDLs) accelerate scientific discovery by automating experimental execution and optimization. AI agents can increasingly propose new experiments, but existing SDLs can only run the procedures they were built for. Adapting them to a new experiment still requires extensive manual engineering, which makes laboratory flexibility the bottleneck for scaling discovery. We introduce the self-building laboratory (SBL), which designs, configures, and operates its own laboratory setup given a high-level scientific goal. SBL starts from whatever already exists, from an empty room to a working SDL, and builds the missing capabilities: the lab layout, its digital twin, robot skills, and experimental workflows. We demonstrate the system working across different robots and setups, scaling from a single workstation to laboratories with several robots working together. We validate SBL's end-to-end capabilities through a real-world quantum-dot synthesis experiment. By shifting human researchers from manually configuring and programming device automation to specifying scientific objectives, SBL makes scientific automation more accessible, flexible, and scalable. Project website: https://self-building-labs.github.io/

Jiaru Bai, Yuchi Zhao, Han Hao +8

Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON M5S 3H6, Canada · Vector Institute for Artificial Intelligence, W1140-108 College St., Schwartz Reisman Innovation Campus, Toronto, ON M5G 0C6, Canada · Department of Computer Science, University of Toronto, 40 St George St., Toronto, ON M5S 2E4, Canada +6

Laboratory Automation Robotic Laboratory Automation Autonomous Experimentation Scientific Workflow Automation

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Oct 9, 2026

DexBioLab: Benchmarking Dexterous Manipulation with Dynamic Experimental Phenomena in Realistic Laboratories

Automating biological laboratories requires robots to perform dexterous tool interactions under realistic visual conditions while handling dynamic experimental phenomena, presenting significant challenges for robotic manipulation. To enable systematic evaluation under these conditions, we introduce DexBioLab, a simulation benchmark and framework for dexterous manipulation in realistic biological laboratory environments. DexBioLab comprises 14 tasks across 4 robot embodiments, spanning functional tool use, precision manipulation, language-conditioned visual grounding, and instrument operation. We introduce controllable dynamic experimental phenomena, including flames, vapor, and bubbles, to capture the evolving visual conditions of laboratory procedures. To further enhance environmental realism, we develop a hybrid rendering pipeline that integrates interactive simulated foreground objects with Gaussian-splatting backgrounds reconstructed from 6 real laboratory scenes. For efficient large-scale data generation and evaluation, we further build a parallel simulation framework on top of mjlab, proposing Parallel Finite-State Machine (PFSM) and integrating batched rendering with decoupled trajectory replay for demonstration generation and model-independent closed-loop policy evaluation. Our evaluation reveals substantial variation in policy performance across tasks, exposing distinct strengths and weaknesses of current manipulation policies. Real-world experiments further demonstrate a reduced sim-to-real gap, supporting the validity of AutoBio+ for realistic manipulation evaluation. Supplementary materials are available at https://cumulusalpha.github.io/DexBioLabWebPage.

Xuanye Wu, Yue Shi, Yongcan Yang +8

Shanghai AI Laboratory · Huazhong University of Science and Technology · University of Southern California +1

Robot Manipulation Benchmarks Robotic Manipulation Robotic Laboratory Automation Robotics Simulation Laboratory Automation Dynamic Robotic Manipulation

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Sep 23, 2026

InternW0: A Foundational Physical World Model for Efficient Real-World Interactions

Physical intelligence requires more than predicting how the world may evolve: predictions must remain actionable as the world continues to change. We introduce InternW0, the first instantiation of the InternW physical world model series from Shanghai AI Laboratory, built around omnimodal interfaces, asynchronous multi-frequency processing, and local physical modeling under partial observations and external influences. InternW0 jointly learns future visual dynamics and continuous robot control through an asymmetric video--action architecture with flow matching. A high-capacity video expert provides longer-horizon predictive context, while a lightweight action expert operates at a faster timescale. Instead of regenerating the future for every action update, InternW0 reuses layerwise K/V and adapts it to newly observed states through observation-conditioned context routing. Domain-specific interfaces and soft prompts support heterogeneous embodiments, while contact-aware post-training incorporates force and tactile signals for contact-rich manipulation. We train InternW0 on approximately 7,200 hours of heterogeneous robot and egocentric data, including EgoLab, a 275-hour real-laboratory egocentric dataset. Evaluation spans simulation benchmarks and real-world scientific tasks, including a 15-stage metal--organic framework synthesis workflow and 5-stage contact- and force-aware dexterous manipulation for general-purpose quantitative pipetting. These results advance scalable, asynchronous, and science-native physical world models for universal and efficient real-world interactions.

Jisong Cai, Yao Mu, Ganlin Yang +23

Physical Intelligence Team, Shanghai AI Laboratory

Robotic Laboratory Automation World Models for Robotics Robotics Robotic Control Efficient Inference for World Action Models

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Sep 16, 2026

WetRobo: A Reproducible Robot Kit for Coding Agents in Biological Laboratories

Automating biological research requires general-purpose, reproducible robot systems that allow individual wet-lab researchers to delegate robot tasks without performing teleoperation or neural-network training. Vision-language-action policies have been proposed for general-purpose arms, but can lose performance when their operating environment changes. We therefore built WetRobo, a robot kit that can readily transfer between laboratories. It consists of one robot arm, laboratory equipment (an incubator, a reagent bottle with a cap, and a Petri dish), the existing code that moves the arm, teleoperation demonstrations of each task that we recorded, and a general AGENTS.md skill file. A biological experimentalist provides natural-language tasks without collecting local teleoperation training data or training a neural network. The coding agent observes the local laboratory and writes and executes programs, using external tools as needed for adaptation. We demonstrate use of WetRobo with OpenAI Codex (gpt-5.6-sol) on three successful tasks: lifting a Petri dish lid, removing a bottle cap, and opening the incubator door, all in real-world laboratories. The coding agent achieved the cap task in both laboratories, Lab X and Lab Y, whereas a VLA fine-tuned on Lab X demonstrations succeeded there but failed to transfer to Lab Y. These results point to a practical route for laboratory robotics: instead of training a policy for each laboratory, distribute a kit and let a coding agent adapt it in each laboratory. Code, demonstrations, and the evolved programs are available at https://github.com/tsudalab/WetRobo.

Yuna Oikawa, Kei Endo, Takanori Uzawa +5

Department of Computational Biology and Medical Sciences, The University of Tokyo, Japan · RIKEN Pioneering Research Institute, Japan · New York University, USA +3

Robot Policy Adaptation Code Generation for Robotics Large Language Model-Based Robot Planning Robotic Laboratory Automation Robotics Laboratory Automation+1

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Sep 3, 2026

A computable representation of the physical laboratory enables verifiable workflows

Making science computable requires representations of both scientific knowledge and the physical world in which scientific claims are tested. A computable representation of the physical laboratory is established through typed research objects, capability-bound operations and a compositional workflow algebra. It provides the physical-world counterpart to machine-readable knowledge, expressing workflows as programs over evolving laboratory states with explicit dependencies, decisions, iteration and concurrency. The representation was implemented in a modular agentic robotic laboratory by binding formal operations to executable Function Skills. For diverse scientific intents, capability-relative workflows were generated, while stateful simulation propagated object transformations and verified operation preconditions and laboratory constraints before dispatch. The proposed representation and its engineering framework jointly establish a general computational interface between agent reasoning and capability-bound physical transformations, providing a foundation for end-to-end autonomous scientific discovery.

Xiaobo Li, Luyao Ge, Xiaohui Li +8

State Key Laboratory of Precision and Intelligent Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, China · Center for Scientific Intelligence Innovation, Hefei, China · Huawei Technologies Co., Ltd.

Robotic Laboratory Automation Agentic Workflows Robotics Laboratory Automation Autonomous Scientific Discovery Scientific Workflow Automation

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Aug 3, 2026

ProtoAct: Turning Wet-Lab Protocols into Embodied Robotic Actions

Biological wet-lab protocols are written for trained researchers and often leave routine operations, state-dependent conditions, and contextual parameters implicit, making them difficult to translate into robot-executable actions. We present ProtoAct, a structured protocol-grounding framework that converts free-form biological procedures into state-aware, embodiment-ready action sequences. ProtoAct uses ProtoRAG to retrieve manually annotated examples for context-sensitive parsing, employs RefineChecker to detect and revise missing or inconsistent steps, and applies ActSchema to map the refined procedure into constrained JSON function sequences. We further introduce BioP2E, for which we manually annotate 22 cell-culture protocols into 258 monitoring conditions, 910 executable subtasks, and 962 grounded action calls. Evaluation across seven large language models demonstrates that ProtoAct can be effectively instantiated with different backbones. Ablations confirm that retrieval, posterior checking, and schema constraints make complementary contributions. The parsed subtasks further support demonstration collection and VLA model training, enabling successful execution in both simulation and real-robot settings. ProtoAct thus provides a practical interface between biological protocol understanding and embodied robotic execution.

Zhe Liu, Jiaming Gu, Zhaohui Du +7

Key Laboratory of Smart Manufacturing in Energy Chemical Process, Ministry of Education, East China University of Science and Technology, Shanghai, China · Department of Computer Science and Engineering, East China University of Science and Technology, Shanghai, China · Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China +1

Robotic Laboratory Automation Robotics Laboratory Automation Language-Conditioned Robot Control Scientific Workflow Automation

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Jul 30, 2026

LabEvolver: Training-Free Experience Evolution for Safe and Grounded Wet-Lab Agents

We introduce LabEvolver, a training-free framework that equips safe and grounded wet-lab agents with episodic memory from execution experience. LabEvolver couples a state-grounded inner trial loop for adaptive perception, online planning, and safety validation with an outer evolution loop that distills completed trajectories into reusable skill, strategy, and safety experience. On robotic solution-preparation tasks, LabEvolver demonstrates real-world feasibility, reducing pH-regulation completion time and safety-gate intercepts by 48.2% and 60.0%, respectively. On ALFWorld, it further improves cumulative success rate within 20 steps from 76.2% with ReAct to 91.4% over 500 continual tasks, showing generality beyond wet-lab settings. These results support learn-by-doing experience evolution as a feasible path toward closed-loop automated scientific discovery. The project page is available at https://andygao6186.github.io/LabEvolver/.

Jingya Wang, Yuyang Gao, Liuzhenghao Lv +2

School of Computer Science, Peking University · School of AI for Science, Peking University · School of Electronic and Computer Engineering, Peking University

Agent Memory AI Agents for Scientific Discovery AI Agent Safety Laboratory Automation Self-Evolving Agents Robotic Laboratory Automation

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Jul 25, 2026

Stress-testing large language model agents in a robotic chemistry laboratory

AI is evaluated through knowledge, reasoning and plan generation, yet scientific agency requires reliable physical action and adaptation to evidence. Here, we use a robotic chemistry laboratory as a physical-world testbed to make scientific agency measurable. Its 45 modular workstations exposed as machine-readable skills enabled 4,608 trials. Only 3.3% of trials produced expert-assessed executable workflows under laboratory constraints; even the best system achieved 28.1%. Long-horizon planning remained a challenge: only three executable workflows exceeded 30 operations, although the longest contained 44. Across five rounds, experimental feedback prompted local adjustments but no workflow-level replanning or analytical-method redesign. By making physical executability and evidence-driven replanning measurable, our study provides an evidence-based assessment of deployment readiness and a diagnostic framework to guide closed-loop improvements towards physically grounded autonomous research.

Lulu Guo, Yingkai Sun, Xiaobo Li +13

AI Agent Reliability AI Agents for Scientific Discovery Robotic Laboratory Automation AI Agent Evaluation Robotics Laboratory Automation+2

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Jul 22, 2026

Scalable Low-Cost Laboratory Automation: A Digital Twin-Integrated Robotic Platform for Autonomous Liquid Handling (RAINBOT)

Laboratory automation accelerates discovery, yet its adoption is constrained by the high cost, proprietary design, and limited remote supervisability of commercial liquid-handling systems. This work presents RAINBOT\textsuperscript{TM}, a low-cost, openly reproducible liquid-handling robot built by converting a consumer-grade Cartesian 3D printer (Elegoo Neptune 4 Max). The printer extruder is replaced by a precision single-channel pipette actuated through the printer's own G-code-driven X--Y--Z gantry, with plunger and tip-eject motions effected by two compact linear actuators under Python control. To make experiments transparent and remotely supervisable, a browser-based digital twin is implemented to synchronise bidirectionally with the physical platform, mirroring kinematics and pipetting states in real time and exposing remote monitoring, intervention, and an emergency stop from any web browser. As a proof of concept, RAINBOT\textsuperscript{TM} performed sequential exchanges of differently coloured aqueous solutions while an integrated colour sensor quantified the resulting mixtures; measured red, yellow, and blue (RYB) responses agreed with expected mixing behaviour to within a mean absolute error of two percentage points, validating correct execution and real-time tracking. Closing the loop, the platform is coupled to the CEID\textsuperscript{TM} (Cooperative Explorer for Inverse Design) framework, which recasts experimentation from iterative manual guessing into a goal-directed inverse-design search while keeping a human in the loop. The complete hardware costs under US$1300, which is roughly an order of magnitude below entry-level commercial handlers, thereby establishing an accessible physical--virtual framework for self-driving laboratory automation.

Mohamed Rami Ayeche, Souhil Sid, Ahyen Mostofa +3

Acceleration Consortium, University of Toronto, Toronto, Canada. · AISCIA Informatics, Qatar Science and Technology Park, Doha, Qatar · Hamad Bin Khalifa University (HBKU), Education City, Doha, Qatar.

Laboratory Automation Robotic Manipulation Autonomous Experimentation Robotic Laboratory Automation

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Jun 30, 2026

Labimus: A Simulation and Benchmark for Humanoid Dexterous Manipulation in Chemical Laboratory

Laboratory automation has made remarkable progress through robotic platforms and AI-driven scientific reasoning. However, many laboratory operations (e.g., solid--solid transfer) remain inherently dynamic and require real-time adaptation to different materials and experimental conditions. Such precision-critical manipulations are difficult to standardize, motivating the use of humanoid robots with dexterous hands. Despite this opportunity, no existing benchmark evaluates humanoid manipulation in precision-critical laboratory environments. We present Labimus, to our knowledge, the first benchmark for humanoid dexterous manipulation in organic chemistry laboratories. Labimus reconstructs over 30 functionally faithful assets from real organic chemistry workstations through real-to-sim modeling, collectively covering the core operations of routine organic chemistry experiments. The benchmark integrates articulated laboratory instruments, particle-based powder physics, and closed-loop instrument readouts, enabling a complete manipulation-to-measurement pipeline. It further defines six atomic operations and a seven-step solid-weighing workflow derived from real laboratory standard operating procedures. We introduce a precision-aware evaluation protocol designed to jointly measure task completion, experimental precision, and long-horizon execution. We benchmark three representative policies under procedural layouts and environmental perturbations. Results reveal a precision gap: policies that successfully complete laboratory tasks can still fail to satisfy the quantitative tolerances required by experimental protocols. Our benchmark exposes a fundamental disconnect between task completion and experimental validity, providing a new testbed for developing reliable humanoid robots for scientific laboratories.

Yuhan Wu, Zhao Jin, Tao Li +9

University of Science and Technology of China · 2Beijing Innovation Center of Humanoid Robotics

Dexterous Manipulation Long-Horizon Robotic Manipulation Robotic Laboratory Automation Robotics Laboratory Automation Robot Manipulation Benchmarks+1

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Apr 14, 2026

Robotic Nanoparticle Synthesis via Solution-based Processes

We present a screw geometry-based manipulation planning framework for the robotic automation of solution-based synthesis, exemplified through the preparation of gold and magnetite nanoparticles. The synthesis protocols are inherently long-horizon, multi-step tasks, requiring skills such as pick-and-place, pouring, turning a knob, and periodic visual inspection to detect reaction completion. A central challenge is that some skills, notably pouring, transferring containers with solutions, and turning a knob, impose geometric and kinematic constraints on the end-effector motion. To address this, we use a programming by demonstration paradigm where the constraints can be extracted from a single demonstration. This combination of screw-based motion representation and demonstration-driven specification enables domain experts, such as chemists, to readily adapt and reprogram the system for new experimental protocols and laboratory setups without requiring expertise in robotics or motion planning. We extract sequences of constant screws from demonstrations, which compactly encode the motion constraints while remaining coordinate-invariant. This representation enables robust generalization across variations in grasp placement and allows parameterized reuse of a skill learned from a single example. By composing these screw-parameterized primitives according to the synthesis protocol, the robot autonomously generates motion plans that execute the complete experiment over repeated runs. Our results highlight that screw-theoretic planning, combined with programming by demonstration, provides a rigorous and generalizable foundation for long-horizon laboratory automation, thereby enabling fundamental kinematics to have a translational impact on the use of robots in developing scalable solution-based synthesis protocols.

Dasharadhan Mahalingam, Michael Gallagher, Nilanjan Chakraborty +1

Department of Mechanical Engineering, Stony Brook University, Stony Brook, NY 11794, USA · Department of Chemistry, Stony Brook University, Stony Brook, NY 11794, USA

Robotic Laboratory Automation Robotics Long-Horizon Robotic Manipulation Robot Motion Planning

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