Transfer Learning

Image demosaicing reconstructs a full-color image from incomplete color measurements produced by a sensor covered with a color filter array (CFA). Most existing methods formulate demosaicing as pixel-level reconstruction and mainly rely on local textures, cross-channel correlations, and low-level image statistics. Our core insight is that reconstruction and visual understanding can be viewed as complementary views of shared scene structure: both are grounded in the same underlying physical world, and therefore the structural and physical information inferred from an image should remain consistent across the two tasks. We instantiate this idea with instance segmentation and propose SegDem, a cross-task decoder representation transfer framework for demosaicing. SegDem first learns region- and boundary-aware representations through instance-aware structural pretraining and then transfers the decoder to RAW-conditioned reconstruction. Segmentation- and demosaicing-conditioned features are further anchored to a shared frozen DINOv2 representation space to preserve structural organization across tasks. We instantiate SegDem with convolutional, Transformer-based, and state-space backbones for unified Single- and Quad-Bayer demosaicing. Extensive experiments on synthetic, external, and challenging datasets demonstrate consistent improvements across different architectures and CFA layouts.

Accurate aneurysm segmentation in 3D rotational angiography (3DRA) is hindered by extreme class imbalance, morphological similarity to vessels, and absent large-scale 3D pretraining. 2D vision foundation models encode dense structural priors from 1.7 billion images, yet naïve slice-wise transfer fragments anatomical continuity and destabilises optimisation. We propose DINO-3DRA, a dual-path framework achieving effective cross-dimensional semantic transfer by injecting frozen DINOv3 features into a 3D U-Net backbone via Room-Lite spatial mixing and calibrated residual fusion. On multi-centre 3DRA data, DINO-3DRA achieves state-of-the-art aneurysm segmentation (Dice: 0.758; HD95: 2.75 mm; +13% over nnU-Net) with only 5.72M trainable parameters. Ablation studies confirm that gains arise from structured cross-dimensional transfer rather than loss design alone, with bridged foundation features improving anatomical continuity between aneurysms and parent vessels. Without fine-tuning on CADA and SHINY-ICARUS, DINO-3DRA eliminates all catastrophic failure cases observed in baseline architectures, demonstrating robust generalisation across heterogeneous imaging protocols.

Hypercomplex numbers extend the concept of complex numbers by introducing additional imaginary components. Besides increasing dimensionality, operations on the imaginary parts provide algebraic and geometrical properties that can be beneficial for solving machine learning problems. In this paper, we show how to create hypercomplex-valued neural network layers where the real part corresponds to the output of a traditional real-valued layer. The additional imaginary parts of these hypercomplex-valued layers produce what we call ghost features,'' which contain enhanced information that is not present in the output of the real-valued layer. Moreover, ghost features can be effectively integrated into a trained neural network through a process we refer to as spooky transfer learning.'' This approach allows us to harness the richness of ghost features, leading to more efficient neural networks. The source code and Jupyter Notebook are available at https://github.com/mevalle/v-nets/.

In transfer learning, the choice of source model largely influences the performance on a target dataset. Still, selecting a fitting source remains a challenging task, especially in medical imaging where one has to decide between models pre-trained on off-the-shelf options, such as ImageNet, and domain specific datasets. Transferability estimation (TE) metrics address this problem by aiming to predict the best performing source model in a computationally cost effective way. However, previous work has reported conflicting TE metric performances due to differences in experimental setups. Moreover, most TE metrics are designed for and evaluated on natural images, while being optimized for accuracy, whereas in medical imaging metrics that are more robust to class imbalance are typically used. We study the impact of varying the target dataset as an isolated factor, by constructing miniature populations of different sample sizes and random seeds. In addition, we investigate the influence of the evaluation metric used to obtain the reference ranking. We find that small modifications to the target dataset change the rankings. Furthermore, we show that the choice of evaluation metric affects the reference rankings and therefore the evaluation of TE metrics. Overall, we observe a low agreement between rankings from TE metrics and reference. The code, model checkpoints and data splits used in this work are available through https://github.com/niclasclassen/robustness-of-transferability-estimation-metrics-for-medical-imaging.

Predicting failures before they occur remains a major challenge in predictive maintenance, particularly when failures are rare, when equipment of the same family differ in sensor configurations, and when the goal is anticipation rather than diagnosis of an already observed fault. This paper proposes a common-to-target probabilistic model that learns shared failure-related patterns across a family of heterogeneous equipment and adapts parsimoniously to target equipment. The model explicitly accounts for sensor heterogeneity, operating context, and degradation dynamics to produce calibrated failureprobability estimates suitable for maintenance planning. Its performance is evaluated on a synthetic refrigerator dataset comprising 27 simulated refrigerators with varying sensor configurations, operating conditions, and failure types, providing a controlle

We investigate the transferability of Earth weather foundation models to planetary atmospheres by adapting the GraphCast graph neural weather forecasting model to Mars. While GraphCast achieves state-of-the-art performance for terrestrial forecasting, its applicability to non-Earth environments remains unexplored. Using the Mars Climate Database (MCD), which provides global atmospheric fields across vertical altitude levels (similar to Earth pressure levels), we evaluate zero-shot and fine-tuned GraphCast predictions of Martian temperature and wind fields. Zero-shot forecasts produce a surprisingly accurate depiction of current conditions but fail to reproduce diurnal variability and rapidly decay toward climatological mean states. To address this limitation, we fine-tune GraphCast using MCD variables and top-of-atmosphere solar radiation forcing while holding humidity constant. Fine-tuning enables rapid learning of Martian thermal variability. Within as few as 10 training epochs, the model begins to capture the diurnal cycle and forecasts up to 10 days reproduce seasonal and vertical temperature structure. Prediction quality improves with training sample size and exhibits sensitivity to seasonal initialization. These results demonstrate that Earth-trained AI weather models can be adapted to simulate Martian atmospheric dynamics, providing a pathway toward rapid planetary weather prediction to support mission operations, dust storm risk mitigation, and future human exploration.

Vision offers a critical axis for advancing foundation models, driving a shift towards natively unified multimodal pretraining. Despite this momentum, the design space and the fundamental mechanisms of how modalities interact during unified training remain underexplored. We provide empirical clarity through a systematic exploration of multimodal pretraining. Our controlled experiments on both synthetic and large-scale real-world datasets yield four key insights into the physics of multimodal pretraining: (i) Knowledge Flow: We disentangle how language, visual understanding, and visual generation transfer knowledge across modalities, revealing distinct patterns of influence and asymmetry; (ii) Synergy vs. Competition: We show that data "complexity" largely determines whether modalities are synergistic, identify architectural choices that promote synergy: such as shared attention and normalization with modality-specific feed-forward layers, and find that these behaviors generalize across different visual tokenizer designs; (iii) Early Unification: Unifying modalities from the very early stages and training them jointly is shown to be more effective than late alignment or sequential training. This process uncovers a vision laziness phenomenon, where delayed integration leads models to rely on language priors; (iv) Recipes: We derive efficient pretraining recipes that achieve strong generative performance using only 5% of the compute budget. These core findings are subsequently validated at scale by training multiple 13.5B MoE models on 2T tokens. We hope this study provides a principled foundation for understanding and scaling multimodal pretraining.

Passive acoustic monitoring is an important tool for biodiversity assessment and wildlife conservation because it supports continuous and non-invasive monitoring of species across large spatial and temporal scales. Robust monitoring remains challenging because many datasets contain sparse positive labels, where species presences may be confirmed while unannotated species cannot be assumed absent. In this work, we study transfer learning under sparse positive labels using BirdCLEF+ 2026 as a target benchmark and BirdCLEF 2021, iNatSounds, WABAD, and BirdSet as external bioacoustic sources. We introduce a multi-source reliability framework that models heterogeneous bioacoustic datasets as distinct supervision sources with differing reliability. Our approach achieves 0.584 macro average precision and 0.860 macro AUC on public BirdCLEF+ 2026 validation labels while outperforming naive source pooling strategies. The strongest gains arise from passive acoustic monitoring datasets and biologically informed source selection. Our findings suggest that transfer learning in bioacoustics is fundamentally a weak supervision and negative transfer problem.

Byte-level language models are usually argued for on the grounds of robustness, multilingual fairness, and character-level skills. We point to a different, structural advantage: because they read and write bytes, any two of them share an output space, so knowledge transfer between them is exact and independent of how either was originally tokenized. We hypothesize that the two distributions a byte-level model produces, one over the next byte, one over where its patch boundaries fall, can be disentangled and changed almost independently. A model could absorb a teacher's capability while keeping its own boundaries, or change how it places those boundaries while keeping its capabilities. We lay out the two experiments that would settle the hypothesis, alongside preliminary measurements of the properties they rest on. We argue that the community should move toward a byte-level interface as a shared standard: if the hypothesis holds, then once byte-level models are the norm, transferring capabilities and reshaping boundaries between them become cheap and routine, free of the per-model tokenizer that blocks them today.

Accurate detection of sedentary behavior is important for studying health risks related to prolonged sitting, but posture-based classification remains challenging with wearable sensors, especially at the wrist. We study whether a deep learning model trained on hip-worn accelerometer data can transfer to wrist-worn accelerometer data for sitting versus non-sitting classification. We use CHAP, a CNN-BiLSTM model originally developed for hip accelerometers, and evaluate its zero-shot performance on wrist data as well as its adaptation through finetuning with varying amounts of labeled wrist data. Experiments are conducted on the iWatch dataset with ground-truth posture labels derived from wearable cameras. The hip-trained model performs strongly on hip data without retraining, but accuracy drops on wrist data due to sensor placement shift. Finetuning CHAP provides consistent advantages over transformer models trained from scratch. These findings suggest that hip-based pretraining provides a useful starting point for wrist deployment, while highlighting the need for wrist-specific adaptation to handle higher signal variability.

Functional near-infrared spectroscopy (fNIRS) is a promising modality for autism spectrum disorder (ASD) classification, yet existing approaches assume temporally aligned evaluation. In practice, the optimal observation window varies across subjects due to differences in hemodynamic delay and neurovascular coupling, creating a temporal distribution shift that degrades performance. We formalize this as a cross-time-window transfer problem, introducing a protocol that varies window length (2.5--10,s) and offset within biological motion trials. Using topographic map representations of fNIRS recordings, we benchmark three vision architectures under two zero-shot baselines and eight adaptation strategies under leave-one-subject-out cross-validation ($N{=}124$). Key findings: (1) zero-shot cross-window accuracy is near chance (54--69%); (2) ${\approx}5\%$ subject-specific fine-tuning recovers 90--96%, while a subject-specific upper bound reaches 97--100%, identifying inter-subject variability as the dominant barrier; (3) domain-adversarial and self-supervised strategies achieve 78--90% without target-subject data; and (4) discriminative information is recoverable from windows as short as 2.5,s. These findings provide a practical roadmap for deploying fNIRS-based ASD classifiers under realistic temporal variability.

Brain-computer interfaces (BCIs) have been widely used in motor rehabilitation, disease diagnosis, and other neural engineering scenarios. However, conventional neural signal decoding algorithms often suffer from limited generalizability and high adaptation costs, motivating recent interest in BCI foundation models. Existing approaches still struggle to jointly achieve general transferability, accurate decoding, and efficient downstream adaptation. We present STEAM, a hierarchical transfer framework that reconciles general-purpose representation learning with paradigm-specific specialization in EEG foundation models. The framework is instantiated as a dual-branch spatio-temporal encoder in which a shared soft mixture-of-experts (SSMoE) module aligns the spatial and temporal branches, allowing complementary representations to exchange information through a compact set of soft slots. Across seven downstream datasets and fourteen evaluation settings, STEAM attains the best average rank among the compared methods at a competitive inference cost measured in FLOPs. Building upon the Stage-I general initialization, the hierarchical pre-training strategy further specializes the model to a target paradigm without retraining from scratch, yielding consistent gains in paradigm-specific decoding accuracy.

High-entropy perovskite oxides (HEPOs) represent a chemically complex class of materials with promising functional properties, yet their vast compositional space and, chemical/structural disorder pose significant challenge for accurate property prediction. Graph neural networks (GNNs) enable rapid exploration of materials space but are often limited by the availability of representative training data. Here, we investigate ordered-to-disordered transfer learning using GNNs for formation-energy and HOMO-LUMO gap prediction in HEPOs by transferring knowledge learned from chemically ordered perovskites. Four representative GNN models, including CGCNN, GATGNN, ALIGNN and M3GNet are evaluated to understand the role of structural representations, spanning pairwise two-body and angular three-body interactions in transfer performance. We find strong property-dependent transfer behavior: formation-energy prediction transfers effectively to disordered HEPOs, whereas HOMO-LUMO gap prediction shows limited transferability due to its sensitivity to local chemical environments. Incorporating a small HEPO-specific training dataset substantially improves HOMO-LUMO gap prediction. Representation-level analysis using UMAP further highlights the importance of encoding three-body geometric information such as in ALIGNN for capturing complex structure-property relationships and improving transferability.

Many real-world graphs support multiple predictive tasks over the same underlying structure, creating an opportunity to reuse supervision across node classification (NC) and link prediction (LP). However, existing evaluations often rely on incompatible splits, observed-graph assumptions, and negative sampling rules, making conclusions about same-graph cross-task transfer unreliable. We formalize same-graph NC-LP transfer and propose a leakage-free protocol that fixes node and edge splits, uses a shared message-passing graph that excludes evaluated edges, and employs fixed negatives for LP. Across three backbones (GCN, GraphSAGE, GPS), we find that transfer is strongly directional and predictable: NC $\to$ LP is consistently beneficial on homophilic graphs, while LP $\to$ NC is fragile and can even degrade accuracy under naive representation reuse. LP $\to$ NC becomes reliably positive mainly in a structure-dominant regime where LP is easy but NC is unsaturated, suggesting that LP acts as structural pretraining. Finally, we introduce the CoTask Score (CTS) to summarize joint NC+LP utility when a shared encoder must serve both tasks, and show that simple dataset statistics, especially homophily, can guide mechanism choice and help avoid negative transfer.

Transferring manipulation skills across object instances that share functionality but differ in geometry remains a fundamental challenge in robot learning. While recent correspondence methods leverage dense visual descriptors and 3D feature fields, nearest-neighbor feature matching often produces spatially incoherent correspondences that fail to recover the local geometric frames required for reliable skill transfer. We introduce SemAnCorr, a training-free framework that establishes dense correspondence by selecting semantically consistent anchor regions through joint pose-correspondence optimization and propagating these constraints over the object surface using functional maps. The resulting correspondences preserve both semantic consistency and geometric coherence, enabling object-centric manipulation skills to transfer across geometrically diverse instances. We evaluate SemAnCorr on a dense correspondence benchmark built on PartNet-Mobility, achieving 90.8% semantic accuracy in our benchmark evaluation while improving geometric coherence over recent state-of-the-art baselines. Finally, we show that these improvements translate directly into real-world manipulation performance: using a single demonstration, SemAnCorr enables substantially more reliable zero-shot manipulation skill transfer to previously unseen objects than existing correspondence methods. Videos and additional visualizations are available at https://semancorr.github.io .

Graph neural networks (GNNs) can operate on large graphs but become infrastructure-sensitive at the scale of millions of nodes and typically require scalable training techniques for even larger graphs. This raises a central question: when can a model trained on a smaller, scaled-down replica of a graph be deployed on the full-resolution graph without retraining? We introduce a zero-shot transfer protocol in which a GNN is trained on a graph coarse-grained by geometric renormalization (GR), and the resulting weights are transferred directly to the original network. Across synthetic and real-world networks, training on GR scaled-down replicas preserves much of the original-scale predictive performance while significantly reducing training cost. We further find that learned representations and predictive trajectories remain aligned across scales. These findings suggest that structural similarity may be more important than network size in determining GNN transferability, opening a path toward scale-equivariant graph architectures.

Learning a strategic task changes more than what is directly taught: fine-tuning on one game can either enhance or degrade an agent's ability to reason in another. Understanding and predicting this transfer of strategic capabilities, however, remains a key challenge for large language models (LLMs). Normal-form games provide an ideal testbed for analyzing this phenomenon, as they feature explicitly defined payoffs and well-characterized equilibrium behaviours. In this work, we investigate whether game embeddings can explain and predict changes in LLM strategic capabilities following fine-tuning across different games. We propose a lightweight two-feature embedding that captures fundamental behavioural demands: the entropy of the Nash equilibrium and the sensitivity of optimal responses to an opponent's action. We show that while existing published structural embeddings primarily memorize game identities and fail to generalize, our behavioural embedding reliably predicts performance changes on held-out games. These results demonstrate that the transfer of strategic capabilities in LLMs is not dictated by the payoff geometry of a game, but by the underlying structure of the decision-making behaviour it requires.

A temporally drifting data stream may pass through discrete regimes rather than changing continuously. We ask whether such regimes are recoverable from the weights of models trained on the stream, using a hidden Markov model (HMM) fit to the chronologically ordered trajectory of those weights. We study this question in two domains known to drift over time: multimodal misinformation detection, using the Fakeddit dataset; and sentiment analysis, using the Yelp dataset. We train classifiers on consecutive temporal windows and fit an HMM to the trajectory of their aligned weights, recovering latent states that partition each timeline into coherent phases. On both datasets, classifiers generalize better to data from windows sharing the state of their training window than to windows across state boundaries. This within-state transfer advantage survives a control for temporal proximity and modestly exceeds the advantage recovered by a naive partition into contiguous states of equal size. Although the states are estimated solely from model weights, they correlate more strongly with shifts in the data's class distribution than with the weight-space geometry used to estimate them. After class divergence and lag are residualized out, the within-state advantage exceeds its permutation null on both tasks, indicating that the states recover structure relevant to transfer beyond the data distribution. Every effect replicates on both tasks but is attenuated on Yelp, whose label distribution is more temporally stable.

Large language model agents often encounter related yet distinct tasks that share reusable solution patterns. Yet standard agentic reinforcement learning treats tasks as independent episodes, while existing approaches to skill learning either focus on repeated attempts of one task or use pipelines with multiple stages that entangle extraction, retrieval, and execution. We introduce SkillRise, a unified reinforcement learning framework for learning skills across tasks. SkillRise organizes related instances into progressively challenging sequences and uses a single policy to alternate between task solving and curating an evolving skill document passed directly to the next task. Decoupled credit assignment across tasks supervises solving with the current task outcome and curation with discounted downstream outcomes. Experiments on ALFWorld, WebShop, and ScienceWorld show that SkillRise achieves the strongest Pass@1 performance among the compared methods, with gains over the strongest baseline ranging from 2.3 to 8.5 percentage points. Although trained across distinct tasks, its learned curation policy remains effective for repeated attempts on the same task. Further analysis reveals scaling at test time across tasks: performance improves with longer sequences of related tasks even when each task is attempted only once. This trend suggests that SkillRise reuses transferable skills across tasks rather than benefiting from repeated sampling of the same task. SkillRise further retains strong performance while substantially reducing the runtime overhead of skill learning pipelines with multiple stages. Together, these results provide a simple and efficient training paradigm for LLM agents to extract, refine, and reuse transferable skills across tasks.

Humanoid robots increasingly require multi-modal understanding for natural interaction with humans. Despite the prominence of vision-language models, they generally assume textual rather than the more natural speech inputs. In this paper, we investigate whether a well-established text-conditioned model can be transferred to speech in a data-efficient manner. Using ALBEF as a case study, we conduct diagnostic analyses showing that a lightweight MLP-based projector effectively adapts it to speech, while preserving semantic discrimination and robustness. Motivated by these findings, we introduce Speech2Grasp, a framework for data-efficient transfer of text-conditioned grasp detection to speech. Real-world humanoid robot experiments show that Speech2Grasp outperforms cascaded ASR-based pipeline, while reducing inference latency. Our findings suggest a practical paradigm for extending established text-conditioned systems to speech.

Graph Foundation Models (GFMs) aim to learn transferable knowledge from multi-domain graphs and adapt to unseen scenarios. As a fundamental source of relational semantics in graphs, the transferability of topological patterns has long been central to GFM research. However, local structural patterns may vary across graphs and even among nodes within the same graph. Despite such structural variation, most existing GFMs rely on manually designed propagation schemes and apply them to new graphs largely unchanged. Such fixed schemes may not suit the diverse structural patterns of different nodes. This raises a key question: can each node autonomously determine how information should be propagated through the graph? We refer to this capability as information-flow control. Inspired by recent advances in agent technology, we formulate this problem as agent-based decision making and treat each node as an agent. Accordingly, we propose AgentGFM, in which all node agents follow a shared end-to-end trainable policy rather than using independent models. For adaptive information-flow control, each node interacts with the graph through a predict-act-observe-correct process. During the act stage, the node makes three decisions: source reception, signal-channel selection and gain-aware node-wise halting. The resulting observation is compared with the prediction and their discrepancy is used to correct the node state and guide subsequent interactions. Extensive experiments across node-level, graph-level and large-scale transfer scenarios demonstrate the effectiveness of AgentGFM across diverse graph topologies.

Enhancing classification performance in mammography remains a persistent challenge across both small curated datasets and large-scale clinical cohorts. Conventional transfer learning approaches often neglect dataset-specific characteristics, while recent neighborhood-informed methods have been restricted to narrow tasks with rigid formulations, limiting their scalability to population-level datasets. To address these challenges, we propose the Dataset-Informed Transfer Learning (DITL) framework, which integrates dataset-derived difficulty signals with neighborhood-based triplet supervision in a unified objective. DITL introduces two adaptive components: (i) Adaptive Difficulty-Weighted Cross-Entropy (A-DWCE), which assigns per-sample weights based on k-nearest neighbor label purity in a self-supervised feature space, and (ii) Adaptive Neighborhood Representation Triplet (A-NR-Triplet), which enforces intra-class compactness and inter-class separation using a learnable margin. Unlike focal loss, DITL requires no hyperparameter tuning, removes heuristic weighting and fixed margins, and incurs negligible computational overhead, yielding a robust and scalable optimization strategy. On the large-scale VinDR-Mammo dataset, DITL achieves state-of-the-art performance for whole-image breast density classification, with significant improvements across accuracy, F1-score, and AUC (p < 0.0001). Beyond large cohorts, DITL also delivers consistent, statistically significant gains on small ROI datasets (p < 0.0001). By bridging small-scale lesion analysis with large-scale density estimation, DITL establishes a clinically relevant, scalable, and generalizable framework for mammography classification, spanning the full breast cancer screening-to-diagnosis spectrum.

Graph foundation models (GFMs) have emerged as a promising paradigm for transferring knowledge across graph domains and tasks. Real-world graphs associate nodes with text, images, and other modalities, making multimodal graphs essential for representing complex entities and relations. Moreover, collecting labels and adapting models for every new graph domain is costly and often infeasible, motivating zero-shot transfer. Unfortunately, zero-shot transfer on multimodal graphs remains underexplored. Existing GNN-based graph foundation models typically require downstream adaptation, whereas LLM-based graph methods mainly address unimodal graphs or tasks within a single domain. This setting presents two key challenges. First, models must generalize knowledge from individual modalities while capturing transferable cross-modal relations. Second, without target-domain fine-tuning, node representations remain entangled with domain-specific structures and modality-specific characteristics, obscuring shared concepts in unseen domains. To address these challenges, we propose CHARM, a multimodal graph foundation model with hierarchical context modeling for zero-shot transfer. CHARM replaces isolated raw nodes with hierarchical graph contexts that capture multimodal semantics and cross-modal relations. These contexts map domain-specific node patterns to shared high-level concepts, reducing reliance on target-domain supervision or adaptation. A modality-aware graph context encoder integrates multimodal information with graph structure and converts the resulting representations into graph tokens for a large language model . Experiments show consistent improvements on zero-shot multimodal graph tasks.

Robotic hardware evolves over time, but demonstration data is often tied to a specific sensor and actuator configuration. This raises a practical and underexplored question: when does legacy data begin to benefit an upgraded robot? We study this question on a wheeled humanoid platform across two hardware generations, where both the camera and gripper are changed while the overall morphology remains fixed. Contrary to the common assumption that more cross-configuration data is always helpful, we observe a grokking-like transition: legacy data remains ineffective until the upgraded configuration acquires a minimum level of task competence, after which co-training gains rise sharply before diminishing near saturation. We hypothesize that this task-dependent transition is governed by a transfer threshold and characterize the resulting three-phase pattern. Across real-robot manipulation tasks, we observe all three phases: no measurable benefit at low competence ($10.0\% \rightarrow 10.0\%$), a sharp gain after crossing the threshold ($23.3\% \rightarrow 86.7\%$ on flower insertion), and diminishing returns at high competence ($85.0\% \rightarrow 93.3\%$ on pen insertion). We provide a theoretical account based on gradient alignment and residual policy uncertainty, and derive a phase-aware rule for deciding when to collect more new-hardware data and when to reuse legacy demonstrations. We further validate this three-phase pattern on a mobile dual-arm watering task, with results consistent with our predictions.

Self-driving laboratories increasingly rely on multi-fidelity Bayesian optimization (MFBO) to balance cheap, approximate evaluations against scarce, expensive ones, with a predictive surrogate at its core. Gaussian processes (GPs) are the default choice, but they scale poorly as data accumulate and assume a smooth landscape that molecular and materials search spaces routinely violate. Transfer learning offers an alternative suited to this regime: it learns a representation from abundant cheap data and adapts it to sparse expensive data. Despite its use in property prediction, transfer learning has not been tested as the engine of a closed-loop optimization. Here we benchmark eleven transfer-learning surrogates against four GP methods under an identical selection rule, fidelity budget, and model size, across nine tasks spanning synthetic functions to real chemistry and materials problems. GPs win on smooth, low-dimensional functions but perform worst on molecular and materials problems, where transfer-learning surrogates reach substantially better solutions using far less computation. Because acquisition policy is held fixed across surrogates, this advantage is attributable to the surrogate itself. Uncertainty-driven exploration is not reliably beneficial, and calibration does not predict optimization performance, so greedy exploitation of the transfer-learned mean is the more robust default. Transfer learning is therefore the surrogate of choice for molecular and materials MFBO.

Calcium imaging has enabled large-scale recordings of neural population activity across diverse animals, laboratories, and experimental paradigms. However, these datasets remain highly fragmented: Existing approaches are often designed for individual datasets or tasks, making it unclear whether their learned representations are reusable for new calcium imaging trace datasets. To tackle this gap, we present CAPT, a Continuous Autoregressive Population Transformer for calcium population dynamics. CAPT models continuous calcium traces directly through a continuous patch tokenization strategy and is trained autoregressively with a mean squared error objective, enabling end-to-end training and adaptation to diverse downstream tasks. We first pretrain CAPT on a large-scale mouse calcium imaging dataset and evaluate its transferability across independent mouse, larval zebrafish, and C. elegans datasets collected by different laboratories. In these transfer settings, the pretrained backbone is frozen and only adaptation modules, i.e., neuron and session embeddings or task-specific heads, are updated. Across neural population forecasting and behavior decoding tasks, CAPT consistently outperforms specialized and general-purpose baselines, demonstrating that a single continuous autoregressive backbone can learn representations that transfer beyond the original pretraining distribution. Beyond predictive performance, multimodal analyses using NeuroPAL annotations in C. elegans datasets show that CAPT embeddings form a shared functional space across datasets and capture cell-identity-related structure. Together, these results suggest that continuous autoregressive modeling provides an effective framework for learning reusable calcium population representations that transfer across datasets, experimental paradigms, and species.

Multi-task learning (MTL) is a promising approach for prediction tasks derived from video game state data, as modern game telemetry provides multiple related supervision signals from the same structured observations. We study whether a shared model trained jointly across tasks in team-based multiplayer games can improve generalization while reducing training and inference cost compared to specialized single-task models. We adapt a multimodal architecture for endpoint prediction to a general multi-task setting that combines rasterized vision inputs, global match context, and per-unit state information through an image encoder and attention-based interaction modeling. Experiments on a large proprietary World of Tanks dataset compare single-task and multi-task training, evaluate weighting strategies for mixed losses and conflicting gradients, and test pre-training/fine-tuning under limited target-data regimes. We also examine within-game transfer across game maps under structured environment shift.

Cross-dataset generalisation remains a major barrier to clinical deployment of echocardiographic left ventricular segmentation, yet the sources of this shift are rarely disentangled. We examined whether transfer degradation could be estimated before deployment using handcrafted ultrasound descriptors, VAE latent features, and segmentation-derived latent features across six echocardiographic datasets. Geometry-aware preprocessing substantially improved several poor transfer cases, suggesting that much of the apparent domain shift reflects field-of-view and framing inconsistencies rather than intrinsic acoustic differences alone. Intensity z-normalisation changed dataset separability by less than 0.005, indicating that brightness and contrast are not the dominant shift axis. Absolute Dice drop on held-out source-target pairs was predicted with an R-squared value of 0.612, an MAE of 0.082, and a Spearman rho of 0.681. The variant without LV and fan-shaped features retained approximately 70% of this explanatory power, supporting mask-free transfer-risk monitoring. The most informative discrepancy measure depended on the representation, with CMD strongest in z-normalised handcrafted features, with an absolute r of approximately 0.86 and an R-squared value of approximately 0.70; log-Wasserstein strongest in VAE space, with an r of approximately -0.90 and an R-squared value of approximately 0.81; and log-MMD strongest in LV-segmentation latent features, with an r of approximately -0.92 and an R-squared value of approximately 0.84. Apparent vendor effects were largely dataset-confounded. Echocardiographic domain shift is therefore structured and measurable, and its impact on segmentation can be partly reduced through geometry-aware preprocessing and anticipated using representation-specific transfer-risk estimation.

The Traffic Assignment Problem is a fundamental but computationally expensive component of transportation planning. While Graph Neural Networks have emerged as fast, data-driven surrogates, their practical deployment is severely constrained by a spatial generalization gap. Standard models rely on transductive feature initializations that tie travel demand to fixed network topologies, preventing seamless transfer to new urban environments. To overcome this structural limitation, this research proposes a network-agnostic initialization layer, termed Geometrically Unconstrained Inductive Demand EmbeDding (GUIDED). By injecting travel demand as a scalar attribute on auxiliary virtual links rather than as specific node features, this modular framework standardizes the input space regardless of network scale. Extensive experimental evaluation across multiple urban topologies demonstrates that a Heterogeneous Graph Attention Network (HetGAT) model integrated with the proposed GUIDED layer maintains state-of-the-art predictive accuracy on single-network tasks, while demonstrating superior robustness to out-of-distribution demand patterns and maintaining a distinct performance advantage over the baseline even under severe data scarcity. Notably, the proposed feature initialization enables highly parameter-efficient domain adaptation for inter-network transfer learning without artificial input homogenization, establishing a robust foundation for truly inductive models. At the same time, the optimized scatter operations of the initialization layer yield an approximate 50% reduction in training time per epoch compared to the baseline approach. Furthermore, while demonstrated on vehicular traffic, this fundamental abstraction of spatial topology provides a versatile blueprint for generalized origin-destination spatial problems, such as freight logistics and multimodal network optimization.

Transferring policies across domains poses a vital challenge in reinforcement learning, due to the dynamics mismatch between the source and target domains. In this paper, we consider the setting of online dynamics adaptation, where policies are trained in the source domain with sufficient data, while only limited interactions with the target domain are allowed. There are a few existing works that address the dynamics mismatch by employing domain classifiers, value-guided data filtering, or representation learning. Instead, we study the domain adaptation problem from a generative modeling perspective. Specifically, we introduce DADiff, a diffusion-based framework that leverages the discrepancy between source and target domain generative trajectories in the generation process of the next state to estimate the dynamics mismatch. Both reward modification and data selection variants are developed to adapt the policy to the target domain. We also provide a theoretical analysis to show that the performance difference of a given policy between the two domains is bounded by the generative trajectory deviation. More discussions on the applicability of the variants and the connection between our theoretical analysis and the prior work are further provided. We conduct extensive experiments in environments with various shifts to validate the effectiveness of our method. The results demonstrate that our method provides superior performance compared to existing approaches, effectively addressing the dynamics mismatch. We provide the code of our method at https://github.com/hanyang-chen/DADiff-release