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Papers 6,721–6,740 of 6,740

May 12, 2026cs.RO

Introducing Environmental Constraints to Grasping Strategies for Paper-Like Flexible Materials Using a Soft Gripper

Robotic manipulation of flexible objects is widely required in both industrial and service applications. Among such objects, paper-like materials exhibit distinct mechanical characteristics compared to cloth, being more sensitive to compressive stress, where minor variations in physical properties can significantly affect grasping. This study systematically investigates grasping strategies for paper-like materials using a universal soft gripper by exploiting environmental constraints. Based on manipulation primitives employed in existing grasping strategies, we proposed systematic grasping strategies for flexible materials by exploiting environmental constraints and analyzed their mechanical and kinematic models. To investigate the influence of materials and working conditions on grasping, an evaluation system for measuring grasping force and success rate was defined and experimentally evaluated. Finally, we summarized the specific workspaces and characteristics of different strategies that can satisfy various task requirements and lead to potential applications in household service robots for grasping planar flexible objects.
Yi Dong, Yang Li, Jinjun Duan +1
May 6, 2026cs.LG

Event-Based Early Warning of Vineyard Disease Risk from Environmental Time Series

Accurate early warning of vineyard disease risk from environmental observations is essential for timely intervention and more sustainable crop protection. However, many existing studies formulate disease prediction as daily presence classification, which can favor persistence-driven predictions and provide only limited support for actionable short-horizon warning. In this paper, we present an event-based approach for early warning of vineyard disease risk from environmental time series and evaluate it through a vineyard case study. Rather than predicting daily disease status, the task is reformulated to predict transitions into annotated disease-risk periods within a future window of 3-7 days. To reduce fragmentation caused by short interruptions in the binary labels, new events are defined only after a minimum disease-free gap. This formulation encourages models to capture environmental precursors associated with upcoming risk periods instead of merely reproducing temporal persistence. Using multi-year agro-meteorological data, we construct input representations that capture humidity dynamics, rainfall accumulation, temperature variability, and seasonal structure through cyclic temporal encoding. We evaluate representative methods from classical machine learning and deep learning, including XGBoost, Long Short-Term Memory (LSTM) networks, and Temporal Convolutional Networks (TCNs), using both standard classification metrics and an event-oriented early warning protocol. The results show that the event-based formulation supports practical short-horizon warning, while the compared models exhibit distinct trade-offs between event recall, lead time, and false-alert behavior. Overall, the study underscores the importance of problem formulation in environmental time-series learning and demonstrates the value of event-based prediction for vineyard disease warning systems.
Ivica Dimitrovski, Ivan Kitanovski, Danco Davcev +2
May 4, 2026cs.LG

HARMES: A Multi-Modal Dataset for Wearable Human Activity Recognition with Motion, Environmental Sensing and Sound

With each sensing modality exhibiting inherent strengths and limitations, multi-modal approaches for wearable Human Activity Recognition (HAR) are becoming increasingly relevant -- particularly for recognizing Activities of Daily Living (ADLs), where individual modalities often produce ambiguous signals for similar or complex activities. This work introduces HARMES, a multi-modal wearable dataset combining three wrist-recorded modalities: motion sensing via an Inertial Measurement Unit (IMU), atmospheric environmental sensors (humidity, temperature, and pressure), and audio. Collected from 20 participants performing household activities in their own homes, HARMES totals over 80 hours of recorded data, with approximately three hours of labeled activity data per participant across 15 ADL classes. To the best of our knowledge, HARMES is the first dataset to combine this particular sensor trio, and it is nearly six times larger than the previously largest wrist-inertial-acoustic HAR dataset. In an extensive benchmark, we evaluate cross-subject generalization and conduct an ablation study revealing that modality contributions are activity-dependent and can provide complementary value, particularly for activities that are ambiguous from motion data alone. HARMES is freely available at Zenodo, alongside example code for loading the dataset and training models on GitHub.
Robin Burchard, Pascal-André Brückner, Marius Bock +2
May 3, 2026cs.CY

The Environmental Cost of LLMs in AIED: Reporting and Practices

Large Language Model (LLM) usage in recent years has become increasingly widespread in the Artificial Intelligence in Education (AIED) community. While LLMs offer unique avenues for learners and educators, using LLMs comes with computational and environmental costs. These costs are mostly hidden due to a lack of standardised procedures to measure and report these impacts. To address this gap, we first conducted a literature review of all papers published as part of the AIED 2025 conference proceedings, determining if and how computational or environmental costs of LLMs are reported. Most projects use LLMs, but few report computational resources used and almost none discuss environmental impacts of LLMs as an ethical concern. To address this lack of standardised reporting practices, we propose an open-source method for systematically measuring and reporting the computational expense of LLMs and environmental impact of running Machine Learning (ML) AIED systems. We provide software solutions to measure the carbon footprint for both local and cloud based hardware. We also provide an easy-to-use formula to calculate the computational expense of frontier LLMs even when the exact number of parameters is not known. Overall, we hope to motivate colleagues to use our method to strive for more transparent reporting of hidden costs of using LLMs in the AIED community.
Sabrina C. Eimler, Lukas Erle, Daniel Flood +5
May 1, 2026cs.CV

Benchmarking ResNet Backbones in RT-DETR: Impact of Depth and Regularization under environmental conditions

Visual perception plays a central role in competitive robotics, where environmental variations can directly affect real-time detection performance. The related literature on transformer-based detectors lack information regarding the impact of backbone scale and environmental settings on model performance. This work presents a comparative evaluation of RT-DETR for detecting round objects under environmental and hyperparameter variations relevant to competitive robotics. Four ResNet backbones (ResNet18, ResNet34, ResNet50, and ResNet101) were compared using dropout rates, analyzing their effect on confidence and accuracy. All models were trained under the same configuration and evaluated under changes in lighting and background contrast. Environmental conditions primarily impact prediction confidence, while inference latency remains largely unaffected and classification accuracy stays consistently high, approaching or above 1.00 in most cases. Two distinct behaviors were observed. Under illumination variation, ResNet50 achieves the best trade-off, combining near-perfect accuracy, confidence values up to approximately 0.869 and latency around 0.058-0.059 ms. Under background variation, ResNet34 provides the most balanced performance, reaching near-perfect accuracy and higher confidence values up to approximately 0.887. These results indicate that the optimal architecture depends on the type of environmental variation, with intermediate-depth models offering the best balance between performance and efficiency.
Pamela Barboza, Víctor Castelli, Belén Pereira +3
Apr 29, 2026cs.LG

Anomaly Detection in Soil Heavy Metal Contamination Using Unsupervised Learning for Environmental Risk Assessment

Soil contamination by heavy metals poses a persistent environmental and public health concern in rapidly urbanising regions of Ghana, particularly at unregulated waste disposal sites. This study applies an unsupervised machine learning framework to detect and characterise anomalous heavy metal contamination patterns in soils from twelve waste sites and residential controls in the Central Region, of Ghana. Concentrations of eight metals (As, Cd, Cr, Cu, Hg, Ni, Pb, Zn) were analysed alongside standard health risk indices, including the Hazard Index (HI) and Incremental Lifetime Cancer Risk (ILCR). Isolation Forest and PCA reconstruction error each identified 1212 anomalous samples (15.4%15.4\% of 7878 samples), while DBSCAN detected no density-isolated noise points. A consensus approach isolated six robust anomalies (7.7%)7.7\%), all spatially concentrated at a single site (S3). Anomalies exhibited approximately 7070--80%80\% higher mean HI values than normal samples, with all consensus anomalies exceeding the HI=1=1 threshold. PCA reconstruction error showed a strong positive association with HI (r≈0.8r \approx 0.8), indicating consistency between multivariate deviation and health risk. Three distinct anomaly types were identified: extreme Cu enrichment at S3, anomalously low Ni at S4/S5, and moderate multi-metal (Pb--Zn) co-elevation at S9--S12. The results demonstrate that unsupervised machine learning provides granular, objective insight beyond aggregate indices, enabling targeted site prioritisation and risk-informed environmental management.
Isaac Tettey Adjokatse, Samuel Senyo Koranteng, George Yamoah Afrifa +6
Apr 23, 2026stat.ML

Revealing Geography-Driven Signals in Zone-Level Claim Frequency Models: An Empirical Study using Environmental and Visual Predictors

Geographic context is often consider relevant to motor insurance risk, yet public actuarial datasets provide limited location identifiers, constraining how this information can be incorporated and evaluated in claim-frequency models. This study examines how geographic information from alternative data sources can be incorporated into actuarial models for Motor Third Party Liability (MTPL) claim prediction under such constraints. Using the BeMTPL97 dataset, we adopt a zone-level modeling framework and evaluate predictive performance on unseen postcodes. Geographic information is introduced through two channels: environmental indicators from OpenStreetMap and CORINE Land Cover, and orthoimagery released by the Belgian National Geographic Institute for academic use. We evaluate the predictive contribution of coordinates, environmental features, and image embeddings across three baseline models: generalized linear models (GLMs), regularized GLMs, and gradient-boosted trees, while raw imagery is modeled using convolutional neural networks. Our results show that augmenting actuarial variables with constructed geographic information improves accuracy. Across experiments, both linear and tree-based models benefit most from combining coordinates with environmental features extracted at 5 km scale, while smaller neighborhoods also improve baseline specifications. Generally, image embeddings do not improve performance when environmental features are available; however, when such features are absent, pretrained vision-transformer embeddings enhance accuracy and stability for regularized GLMs. Our results show that the predictive value of geographic information in zone-level MTPL frequency models depends less on model complexity than on how geography is represented, and illustrate that geographic context can be incorporated despite limited individual-level spatial information.
Sherly Alfonso-Sánchez, Cristián Bravo, Kristina G. Stankova
Apr 21, 2026cs.SD

Environmental Sound Deepfake Detection Using Deep-Learning Framework

In this paper, we propose a deep-learning framework for Environmental Sound Deepfake Detection (ESDD) - the task of identifying whether the sound scene and sound event in an input audio recording is fake or real. To this end, we first conduct extensive experiments to explore how individual spectrograms, a wide range of network architectures, and pre-trained models affect the performance of an ESDD model. The experimental results on the benchmark datasets of EnvSDD indicate that detecting deepfake audio of sound scenes and detecting deepfake audio of sound events should be considered as individual tasks. We also show that fine-tuning a pre-trained model is more effective than training a model from scratch for ESDD. Ultimately, our best model, which fine-tunes the pre-trained BEATs model using the proposed two-phase training strategy, achieves an Accuracy of 0.98, F1 score of 0.95, and AUC score of 0.99 on the Test subset of the EnvSDD dataset. Our best model also achieves an Accuracy of 0.86, F1 score of 0.80, and AUC of 0.93 when evaluated cross-dataset on the ESD-Challenge-TestSet dataset.
Khoi Vu, Dat Tran, Khanh Do +8
Apr 20, 2026cs.CL

Characterizing AlphaEarth Embedding Geometry for Agentic Environmental Reasoning

Earth observation foundation models encode land surface information into dense embedding vectors, yet the geometric structure of these representations and its implications for downstream reasoning remain underexplored. We characterize the manifold geometry of Google AlphaEarth's 64-dimensional embeddings across 12.1 million Continental United States samples (2017--2023) and develop an agentic system that leverages this geometric understanding for environmental reasoning. The manifold is non-Euclidean: effective dimensionality is 13.3 (participation ratio) from 64 raw dimensions, with local intrinsic dimensionality of approximately 10. Tangent spaces rotate substantially, with 84% of locations exceeding 60\textdegree{} and local-global alignment (mean∣cos⁡θ∣=0.17|\cosθ| = 0.17) approaching the random baseline of 0.125. Supervised linear probes indicate that concept directions rotate across the manifold, and compositional vector arithmetic using both PCA-derived and probe-derived directions yields poor precision. Retrieval instead produces physically coherent results, with local geometry predicting retrieval coherence (R2=0.32R^2 = 0.32). Building on this characterization, we introduce an agentic system with nine specialized tools that decomposes environmental queries into reasoning chains over a FAISS-indexed embedding database. A five-condition ablation (120 queries, three complexity tiers) shows that embedding retrieval dominates response quality (μ=3.79±0.90μ= 3.79 \pm 0.90 vs.\ 3.03±0.773.03 \pm 0.77 parametric-only; scale 1--5), with peak performance on multi-step comparisons (μ=4.28±0.43μ= 4.28 \pm 0.43). A cross-model benchmark show that geometric tools reduce Sonnet 4.5's score by 0.12 points but improve Opus 4.6's by 0.07, with Opus achieving higher geometric grounding (3.38 vs.\ 2.64), suggesting that the value of geometric characterization scales with the reasoning capability of the consuming model.
Mashrekur Rahman, Samuel J. Barrett, Christina Last
Apr 20, 2026cs.LG

Implicit neural representations as a coordinate-based framework for continuous environmental field reconstruction from sparse ecological observations

Reconstructing continuous environmental fields from sparse and irregular observations remains a central challenge in environmental modelling and biodiversity informatics. Many ecological datasets are heterogeneous in space and time, making grid-based approaches difficult to scale or generalise across domains. Here, we evaluate implicit neural representations (INRs) as a coordinate-based modelling framework for learning continuous spatial and spatio-temporal fields directly from coordinate inputs. We analyse their behaviour across three representative modelling scenarios: species distribution reconstruction, phenological dynamics, and morphological segmentation derived from open biodiversity data. Beyond predictive performance, we examine interpolation behaviour, spatial coherence, and computational characteristics relevant for environmental modelling workflows, including scalability, resolution-independent querying, and architectural inductive bias. Results show that neural fields provide stable continuous representations with predictable computational cost, complementing classical smoothers and tree-based approaches. These findings position coordinate-based neural fields as a flexible representation layer that can be integrated into environmental modelling pipelines and exploratory analysis frameworks for large, irregularly sampled datasets.
Agnieszka Pregowska, Hazem M. Kalaji
Mar 10, 2026cs.RO

Autonomous Search for Sparsely Distributed Visual Phenomena through Environmental Context Modeling

Autonomous underwater vehicles (AUVs) are increasingly used to survey coral reefs, yet efficiently locating specific coral species of interest remains difficult: target species are often sparsely distributed across the reef, and an AUV with limited battery life cannot afford to search everywhere. When detections of the target itself are too sparse to provide directional guidance, the robot benefits from an additional signal to decide where to look next. We propose using the visual environmental context -- the habitat features that tend to co-occur with a target species -- as that signal. Because context features are spatially denser and often vary more smoothly than target detections, we hypothesize that a reward function targeted at broader environmental context will enable adaptive planners to make better decisions on where to go next, even in regions where no target has yet been observed. Starting from a single labeled image, our method uses patch-level DINOv2 embeddings to perform one-shot detections of both the target species and its surrounding context online. We validate our approach using real imagery collected by an AUV at two reef sites in St. John, U.S. Virgin Islands, simulating the robot's motion offline. Our results demonstrate that one-shot detection combined with adaptive context modeling enables efficient autonomous surveying, sampling up to 75%\% of the target in roughly half the time required by exhaustive coverage when the target is sparsely distributed, and outperforming search strategies that only use target detections.
Eric Chen, Travis Manderson, Nare Karapetyan +3
Mar 7, 2026cs.LG

AI-Driven Predictive Maintenance with Environmental Context Integration for Connected Vehicles: Simulation, Benchmarking, and Field Validation

Predictive maintenance for connected vehicles offers the potential to reduce unexpected breakdowns and improve fleet reliability, but most existing systems rely exclusively on internal diagnostic signals and are validated on simulated or industrial benchmark data. This paper presents a contextual data fusion framework integrating vehicle-internal sensor streams with external environmental signals -- road quality, weather, traffic density, and driver behaviour -- acquired via V2X communication and third-party APIs, with inference at the vehicle edge. The framework is evaluated across four layers. A feature group ablation study on a physics-informed synthetic dataset shows contextual features contribute a 2.6-point F1 improvement; removing all context reduces macro F1 from 0.855 to 0.807. On the AI4I 2020 benchmark (10,000 samples), LightGBM achieves AUC-ROC 0.973 under 5-fold stratified cross-validation with SMOTE confined to training folds. A noise sensitivity analysis shows macro F1 remains above 0.88 at low noise and degrades to 0.74 at high noise. Most critically, the pipeline is validated on real-world telemetry from five vehicles across three countries (India, Germany, Brazil), comprising 992 trips and 11 evaluable service events identified from component wear resets in the trip logs. Across six wear-driven events spanning four vehicles, the model achieves 100% detection with mean MAE of 12.2 days. A fine-tuning ablation shows the base synthetic model already achieves 6/6 binary detection; per-vehicle adaptation reduces wear-driven MAE from 25.9 to 12.2 days. SHAP analysis confirms contextual and interaction features rank among the top 15 predictors. Edge-based inference reduces estimated latency from 3.5 seconds to under 1.0 second relative to cloud-only processing.
Kushal Khemani, Anjum Nazir Qureshi
Oct 10, 2025cs.LG

The Environmental Impacts of Language Model Training Keep Rising Now is the Time to Catch Impacts on the Rebound

Recent Machine Learning (ML) approaches have shown increased performance on benchmarks at the cost of escalating compute demands. Hardware, algorithmic and carbon optimizations have been proposed to curb energy use and environmental impacts. We estimate the environmental impacts associated with training models documented in the Epoch AI database over the last decade, with a particular focus on impacts associated with Large Language Models and the hardware used to train them. We find that energy use and environmental impacts associated with training ML models have increased exponentially, even when considering impact reduction strategies such as using less carbon intensive electricity mixes or more efficient hardware. Optimization strategies do not mitigate the impacts induced by model training, suggesting rebound effect. We show that the impacts of hardware must be considered over the entire life cycle rather than the sole use phase in order to avoid impact shifting. Our study demonstrates that increasing efficiency alone does not ensure sustainability. There is an urgent need to systematically integrate environmental impacts in NLP evaluation practices to better inform the community and support the use of impact as a feature in research planning and decision making.
Clément Morand, Anne-Laure Ligozat, Aurélie Névéol
Jul 11, 2025cs.SD

Enforcing Speech Content Privacy in Environmental Sound Recordings using Segment-wise Waveform Reversal

Environmental sound recordings often contain intelligible speech, raising privacy concerns that limit analysis, sharing and reuse of data. In this paper, we introduce a method that renders speech unintelligible while preserving both the integrity of the acoustic scene, and the overall audio quality. Our approach involves reversing waveform segments to distort speech content. This process is enhanced through a voice activity detection and speech separation pipeline, which allows for more precise targeting of speech. In order to demonstrate the effectivness of the proposed approach, we consider a three-part evaluation protocol that assesses: 1) speech intelligibility using Word Error Rate (WER), 2) sound sources detectability using Sound source Classification Accuracy-Drop (SCAD) from a widely used pre-trained model, and 3) audio quality using the Fréchet Audio Distance (FAD), computed with our reference dataset that contains unaltered speech. Experiments on this simulated evaluation dataset, which consists of linear mixtures of speech and environmental sound scenes, show that our method achieves satisfactory speech intelligibility reduction (97.9% WER), minimal degradation of the sound sources detectability (2.7% SCAD), and high perceptual quality (FAD of 1.40). An ablation study further highlights the contribution of each component of the pipeline. We also show that incorporating random splicing to our speech content privacy enforcement method can enhance the algorithm's robustness to attempt to recover the clean speech, at a slight cost of audio quality.
Modan Tailleur, Mathieu Lagrange, Pierre Aumond +1
Jun 3, 2022physics.soc-ph

Simulation of Crowd Egress with Environmental Stressors

This article introduces a modeling framework to characterize evacuee response to environmental stimuli during emergency egress. The model is developed in consistency with stress theory, which explains how an organism reacts to environmental stressors (e.g., alarm signals or hazardous factors such as smoke and fire). We integrate the theory into the well-known social force model, and develop a framework to simulate crowd evacuation behavior in multi-compartment buildings. Our method serves as a theoretical basis to study crowd movement at bottlenecks, and simulate their herding behavior and way-finding activities in normal and hazardous conditions. The pre-movement behavior is also investigated by using opinion dynamics with a social group model. The algorithms have been partly tested in FDS+EVAC as well as our simulation platform crowdEgress.
Peng Wang, Xiaoda Wang, Peter Luh +4
Sep 28, 2026cs.CV

Modeling Whole-Slide Images as Dynamic Tumor Microenvironment Fields

Due to the gigapixel-scale nature of whole-slide images (WSIs), weakly supervised WSI analysis is commonly formulated as a multiple instance learning (MIL) problem, where patch-level features are aggregated into slide-level representations. However, diagnostic and prognostic evidence often arises from spatially coherent tumor microenvironment regions and their interactions, rather than isolated patches alone. Existing patch-level or static region-based methods usually overlook how tissue regions should be adaptively formed and subsequently evolved through microenvironment interactions across heterogeneous boundaries. In this paper, we propose Concept-Guided Tumor Microenvironment Evolution (TMEvolve), a reaction-diffusion-inspired framework that models WSIs as latent tumor microenvironment fields over discrete patch graphs. TMEvolve instantiates this view as a learnable graph-discretized evolution process over patch neighborhoods. It first forms adaptive soft tissue regions as coherent microenvironment units, then performs pseudo-time evolution through two complementary local dynamics: intra-region diffusion, which stabilizes latent states within coherent tissue compartments, and concept-guided boundary flux, which propagates visual feature signals and language-derived concept signals across heterogeneous region interfaces. The evolved microenvironment regions are finally aggregated for slide-level prediction. We evaluate TMEvolve on six datasets across three weakly supervised WSI tasks: survival prediction, gene expression prediction, and histological subtype classification. TMEvolve consistently improves over representative MIL methods, pathology foundation models, and concept-guided baselines. Ablation studies and visualizations further support the effectiveness and interpretability of TMEvolve, highlighting the value of dynamic region modeling and boundary interaction.
Lei Wu, Jiashuai Liu, Di Zhang +9
Jul 20, 2026cs.CV

GigaPath-Flash and GigaTIME-Flash: Efficient Pathology Foundation Models for Whole-Slide and Tumor Microenvironment Analysis

Foundation models have emerged as a driving force in computational pathology, with the potential to transform cancer diagnosis, prognosis, and treatment selection by learning transferable representations from large-scale histopathology data. A growing landscape of pathology foundation models now spans diverse data sources, architectures, and downstream applications. However, most pretrained models operate only at the image-tile level, use restrictive licenses, and remain computationally expensive, limiting large-scale slide-level clinical and research use. Here, we introduce GigaPath-Flash and GigaTIME-Flash, efficient models for whole-slide pathology AI and spatial proteomics prediction. GigaPath-Flash combines a 22M-parameter ViT-S tile encoder with a 21M-parameter LongNet slide encoder, both pretrained on large-scale real-world histopathology data. Its compact tile encoder is distilled from the billion-parameter GigaPath (ViT-g) teacher and shared by both models. GigaPath-Flash retains 97% of GigaPath's average slide-level performance with 50x less compute. GigaTIME-Flash extends this backbone to predict the tumor immune microenvironment directly from routine H&E images. It surpasses the original CNN-based GigaTIME in prediction quality while running 6x faster and using 8x less GPU memory. Together with GigaPath and GigaTIME, these models form an open-weight, Apache-2.0-licensed family pretrained on large-scale real-world clinical data. By releasing all models and weights, we provide accessible building blocks for computational pathology, immuno-oncology, and precision health.
Naoto Usuyama, Jeya Maria Jose Valanarasu, Sicong Yao +27
Jun 16, 2026cs.CV

SegTME-UNI2: A Foundation Model-Based Framework for Generalisable Multiclass Cell Segmentation and LLM-Driven Tumour Microenvironment Characterisation in Histopathology

Characterising the TME from routine H&E-stained histology images requires simultaneous cell segmentation, biological feature extraction, and interpretable clinical reporting. We present SegTME-UNI2, a unified framework addressing all three requirements end-to-end: a segmentation backbone that converts raw H&E patches into per-nucleus class labels, a structured feature-extraction pipeline that turns those labels into quantitative TME descriptors, and a language-model narrative generator that turns those descriptors into clinician-readable text. At its core is UNI2-UperHoVer, a dual-head multiscale segmentation model that pairs UNI2 with two parallel UperNet decoders: one for six-class semantic segmentation and one for HV gradient regression enabling watershed-based nuclear instance separation. It is trained via a three-stage progressive pseudo-label curriculum, scaling from PanNuke (Stage 1, 0.25um/pixel) to TCGA-UT Scale-0 (Stage 2, 0.5um/pixel) and full 1.6M-patch, six-scale TCGA-UT (Stage 3, 0.5 to 1.0um/pixel). TCGA-UT's coarser, broader per-patch context than PanNuke's also permits a larger tile stride during whole-slide inference. This pipeline computes 22 per-patch compositional, morphological, spatial-entropy, and intercellular-distance metrics and translates them into six categorical phenotype labels and a standardised biological-token vocabulary, fine-tuned via NVIDIA BioNeMo that converts into clinically grounded narratives whose individual claims can be spot-checked directly against the underlying features. Qualitative validation on IGNITE NSCLC tiles shows the pipeline produces biologically coherent phenotype classifications and narratives despite inter-institutional stain variability and imperfect segmentation. The pseudo-labelled TCGA-UT dataset and UNI2-UperHoVer checkpoints are publicly released to support large-scale TME profiling and spatial biology research.
Wan Siti Halimatul Munirah Wan Ahmad, Faris Syahmi Samidi, Mohammad Badal Ahmmed +3
Sep 28, 2026cs.LG

NeuronSifter: Intervention Planning in CNS Microenvironments

Prioritizing central nervous system (CNS) interventions requires predicting how a dose, route, and schedule act on a partially observed microenvironment, then choosing the measurement that would change the decision. Action-conditioned predictors reduce a regimen to an identity token or a scalar exposure, discarding where and when the target is engaged; handing a point estimate to a separate planner then discards the joint uncertainty that makes a measurement worth running. We therefore treat decision quality as a property of the intervention interface, not of controller placement. NeuronSifter compiles regimens into state-conditional target-occupancy fields with support masks, propagates them through microenvironment dynamics with an occupancy-conditioned diffusion operator, and selects measurements by their expected reduction in intervention loss, assimilating typed outcomes into the same posterior. In a declared synthetic Alzheimer's disease (AD) evaluation over 64 paired scenario blocks, occupancy conditioning lowers trajectory continuous ranked probability score from 0.165 to 0.110 and raises intervention ordering accuracy from 0.760 to 0.880, and every paired benchmark contrast remains separated after Holm correction. Decision-directed acquisition attains terminal risk 0.160 against 0.166 for a matched numerical Bayesian experimental design planner, and reaches the target risk at 0.796 [0.732,0.873][0.732,0.873] of an earlier design control's cost, while the corresponding ratio against the matched planner, 0.963 [0.907,1.025][0.907,1.025], is not separated from equality; point-state and dependence-ablated interfaces instead raise risk to 0.220 and 0.199, and a full-posterior external controller ties exactly. Published AD trials supply a separate retrospective endpoint bridge.
Haowei Xu, Wanyi Fu, Hongbin Han +1
Sep 28, 2026cs.LG

NeuronDiscover: Agent-in-Twin for Mechanistic Discovery in Neuronal Microenvironments with World Action Models

Mechanistic discovery in neuronal microenvironments requires interventions and measurements that separate competing explanations of solute transport and neuronal response. Predictive accuracy cannot settle the question: a real mechanistic change and an error in the computational twin leave the same signature in sparse observations. We formalize this twin confounding and reason over a joint mechanism--discrepancy belief, designing experiments that separate the two. NeuronDiscover is an Agent-in-Twin framework whose shared, mechanism-grounded World Action Model (WAM) couples prediction, intervention proposals, and observation design; independently adjudicated outcomes revise a scoped Mechanism--Intervention--Observation--Outcome (MIOY) graph, whose supported relations compile into executable programs carrying discrepancy-adjusted acceptance bounds. We evaluate on simulated brain-fluid tracer-transport worlds adjudicated by an independently frozen finer-mesh reference solver, and on donor-disjoint public current-clamp recordings of cortical neurons. Counting only relations that reach a certified terminal status, and scoring abstentions as unresolved for every method, at a matched budget of 16 experiments over 32 source units NeuronDiscover resolves 4.0 relations per assigned world against 3.4 for the strongest baseline and 3.2 without graph revision, at 5% false support and 82% scope accuracy. Joint mechanism--discrepancy acquisition resolves 3.8 relations versus 2.9 for plug-in expected information gain; discrepancy-adjusted verification lowers accepted-program failure from 15% to 9% at 60% acceptance coverage; and transfer to the recordings yields 1.94 versus 1.53 relations per assigned world. Correctness is adjudicated within declared model worlds and archival recordings.
Haowei Xu, Wanyi Fu, Hongbin Han +1