Missing Modalities

Recent multimodal sentiment analysis studies increasingly adopt text-centric fusion approaches to exploit the rich sentiment information inherent in the textual modality. However, these approaches often suffer from performance degradation during inference due to partially missing or noisy data in real-world scenarios, especially when sentiment-related cues are missing. To address this issue, we introduce a new completeness estimation approach that quantifies the degree of sentiment-relevant information preserved in incomplete data to guide the reconstruction of missing semantics. Furthermore, we propose a training strategy that stabilizes multi-task learning while jointly optimizing sentiment prediction and completeness estimation. Extensive experiments and in-depth analyses on three benchmark datasets demonstrate that the proposed approach enables more accurate semantic reconstruction, leading to more precise sentiment prediction.

Vision-language models are increasingly used in settings where some input modalities may be unavailable, yet we know little about whether they can faithfully explain how such missing information affects their own predictions. We introduce an interventional protocol for evaluating self-explanations of modality dynamics: models state what each modality alone would support, whether restoring a missing modality would change their answer, and whether the available evidence is sufficient; we then execute the corresponding modality intervention and compare these claims with the model's realized behavior. We evaluate eight open-weight VLMs from two model families across four tasks spanning complementary and isomorphic text-image settings and a multi-view driving setting. We find a systematic tendency to overstate the sufficiency of available modality evidence. Models substantially underestimate the effect of restoring missing modalities: task-level median predicted change rates are at most 8.8%, while the corresponding executed change rates reach 72.1%, with underprediction in 62 of 64 model-task-condition settings. Insufficiency claims are rare, but precise when produced: restoring the modality changes the answer in a median of 78-100% of flagged cases. Retrospective self-explanations show the same tendency: on complementary data, models over-credit single-modality sufficiency; on isomorphic data, they over-credit single representation sufficiency relative to their executed behavior. Together, these results show that VLMs systematically mischaracterize how their predictions depend on available and missing modality evidence, motivating executable interventions as a behavioral ground truth for evaluating multimodal self-explanations.

Depression and anxiety in older adults with Mild Cognitive Impairment (MCI) are frequently underdiagnosed due to limited access to care. Multimodal analysis of remote clinical interviews is a scalable screening approach, but existing methods have three limitations. First, they do not correct temporal misalignment across multimodal features extracted at different resolutions, inducing spurious cross-modal associations. Second, remote recordings exhibit uneven modality dropout, but missing values are often zero-filled, making them indistinguishable from valid near-zero measurements. Finally, they do not jointly attribute predictions to modalities, questions, and interview moments, limiting fine-grained clinical interpretation. We propose a Temporally-Aligned, Missingness-Aware, Interpretable (TAMI) multimodal fusion framework. TAMI aligns speech, language, facial, and physiological features within question-answer segments on a shared timeline, encodes modality-level missingness over time, and conditions fusion on question context. In interviews with 49 older adults with MCI, TAMI achieved area under the receiver operating characteristic curve (AUROC) scores of 0.68 (depression) and 0.69 (anxiety). Fine-grained temporal alignment of multimodal features produced the largest performance gain ($Δ{\geq}0.1$). Multi-level interpretability analysis revealed that depression classification relied on eyegaze and open-ended questions, while anxiety classification depended on eyegaze and head pose, with attribution uniformly distributed across questions. Using only responses to the open-ended questions (5.1min), the depression model achieved an AUROC score of 0.67, which was not significantly different from using the full interview (19min) ($p>0.05$). Our findings support designing interview protocols centered on open-ended questions for depression screening in older adults with MCI.

Multimodal federated learning (FL) supports collaborative modeling in privacy-sensitive health-sensing and medical settings, but realistic deployments often exhibit dual-axis modality missingness: clients have different modality sets, and individual samples may contain only subsets of the modalities available locally. Existing methods typically address these two axes separately. We propose Flux, a multimodal federated learning framework built around two complementary components. First, modality-aware confidence tempering learns sample-specific confidence for each modality through mask-aware unimodal supervision and fuses the confidence estimates from observed modalities into a sample-adaptive temperature that adjusts predictive sharpness according to evidence quality and completeness. Second, gradient-decoupled private adaptation applies this temperature only to a client-private prediction pathway, while training the shared federated model with a standard, untempered objective. This enables sample-specific, client-local confidence adaptation without allowing confidence-dependent gradients to perturb shared representation learning. Across four multimodal datasets, Flux achieves the highest average macro-F1 on every dataset, outperforming the strongest dataset-specific baseline by 0.8~2.2 points and by 1.6 points on average. Additional analyses demonstrate favorable calibration, temperature sensitivity to both modality missingness and input corruption, and more stable shared optimization under private-only tempering. Our code is available at https://github.com/AdibaOrz/Flux.

Prediction intervals for multi-modal regression with tabular variables, text, images, or other input sources are difficult to calibrate when those sources disagree or one is missing. A single global quantile averages these regimes together instead of calibrating to the modality pattern observed at test time. We address this through a modality-aware conformal calibration layer. The layer trains or reuses one predictor per modality, computes a disagreement score from their predictions, and uses that score in split conformal calibration under a strict split protocol. We use the score in two complementary ways. First, a continuous disagreement-scaled method reallocates interval width across examples while preserving the usual marginal split-conformal guarantee. Second, a Mondrian (stratified) method calibrates within groups defined by disagreement or modality availability fixed before calibration, giving group guarantees under joint exchangeability of the calibration and test examples. Across four multi-modal datasets, the disagreement-scaled layer matches or improves the marginal conformal baseline in 59 of 60 paired runs for interval continuous ranked probability score (CRPS) and in 52 of 60 for interval width, while keeping empirical coverage near the 95% target. In stress tests with missing modalities, mask-matched recalibration recovers up to 19.5 percentage points of coverage in the hardest fixed-mask regime. The result is a simple, model-agnostic reliability layer for multi-modal regression systems. A project page is available at https://unco3892.github.io/modality-aware-conformal.

Multimodal fusion architectures typically assume all modalities are available at inference, yet sensor failures, acquisition variability, and cost constraints routinely produce incomplete observations. Existing work treats modality absence as a prediction-accuracy problem, leaving a more basic question unanswered: whether a model's confidence estimates remain calibrated when an entire input stream is removed. We argue that missing-modality robustness and calibrated uncertainty are a single coupled property, and introduce Modality-Conditioned Conformal Fusion (MCCF), an architecture that addresses both at once. MCCF combines a multimodal bottleneck fusion backbone trained with modality dropout, per-modality evidential heads producing modality-decomposed Dirichlet distributions, and a Dempster-Shafer combination rule that fuses the per-modality evidence into a joint predictive distribution; an absent modality contributes vacuous evidence that is structurally ignored, so the fused uncertainty automatically reflects the reduced information without test-time imputation. A Mondrian conformal calibration module keyed on the modality-presence mask then provides finite-sample group-conditional coverage for every non-empty modality subset. MCCF is, to our knowledge, the first method with formal coverage guarantees under arbitrary modality availability through architectural integration rather than post-hoc recalibration, and the evidential decomposition yields per-modality vacuity scores that localise uncertainty to the absent modality responsible. Across a synthetic problem and three real multimodal benchmarks, MCCF holds its target coverage on every modality-presence subset, substantially narrows the coverage gap between full and partial modalities relative to a marginal split-conformal baseline, and imposes no measurable accuracy cost relative to temperature-scaled and evidential baselines.

In multimodal crack segmentation for industrial facilities, the key challenge is preventing missing modalities from degrading pixel-level performance while maintaining low computational cost. Existing methods struggle to address semantic degradation caused by missing modalities. We propose Compass, a lightweight network for robust crack segmentation under arbitrary missing modalities. Compass comprises Degradation Simulation Distillation (DSD), Needle Block, and Evidential Topology-Preserving Fusion (ETPF). DSD constructs a degradation simulation stream that mimics more severe missing conditions and performs reciprocal distillation with the original stream, decoupling complete perception from degradation adaptation. Within DSD, Feature-Aware Prototype Transmitter (FAPT) performs modality agnostic prototype-guided feature completion to maintain semantic integrity under incomplete modality conditions. As a lightweight backbone, Needle injects crack-direction cues into WKV modulation and combines connectivity-aware gating with anisotropic context probing for structure-aware modeling. ETPF fuses multimodal features via Dempster-Shafer evidential combination with uncertainty-gated decoding, preserving crack topology while suppressing unreliable features. Experiments on three datasets demonstrate state-of-the-art (SOTA) performance under diverse missing modality scenarios. Even with 90% depth modality missing on CrackDepth, Compass achieves F1 of 0.8216 and mIoU of 0.8434 with only 2.58M parameters. The code is available at https://github.com/Karl1109/Compass.

Longitudinal multiparametric MRI is central to follow-up imaging in oncology, yet real-world clinical data are characterised by missing sequences, heterogeneous acquisition protocols, and varying spatial resolutions across time points. We propose a patient-specific conditional implicit neural representation (INR) that models multimodal longitudinal MRI as a continuous function of world coordinates, time, and modality conditioning. The model is trained with stochastic modality dropout to handle incomplete data, and its continuous coordinate-space formulation enables both spatial and temporal interpolation without resampling to a fixed voxel grid. A self-consistency-based confidence estimator is derived from cross-modal reconstruction performance at inference time. We evaluate the framework on longitudinal MRI from paediatric brain tumour patients, demonstrating statistically significant improvements over linear interpolation for T1CE and FLAIR (p < 0.05), with mean MS-SSIM of 0.95 $\pm$ 0.02 for T1CE. Predicted confidence correlates strongly with true reconstruction quality (Pearson r up to 0.996), suggesting reliable deployment potential in heterogeneous clinical settings.

Missing modalities in RGBT tracking often lead to incomplete and unstable multimodal feature representations that greatly degrade the performance. Existing methods typically attempt to recover missing modalities from available ones, but the quality of data generated in challenging scenarios might be unsatisfactory. In addition, current approaches exhibit limited flexibility in processing both missing and complete data. To overcome these limitations, we propose a Spatio-temporal Conditional Denoising Transformer (SCDT), which integrates the spatial cues and the temporal context to adaptively perform information reconstruction of missing modalities and feature enhancement of weak modalities in a unified framework, for robust modality-missing RGBT tracking. In particular, SCDT leverages the short-term temporal cues from recent historical frames to capture the fine-grained temporal correlations and the long-term temporal cues encoding modality evolution to capture the global context. By jointly exploiting long short-term temporal contexts as the conditions, SCDT progressively guides noisy features of available modalities to learn reliable and temporally consistent multimodal representations. Furthermore, SCDT introduces a noisemodulated adaptation mechanism that dynamically adjusts its behavior according to the modal availability, enabling a single framework to unify feature learning under both modality-missing and complete scenarios without changing the architecture or parameters. Extensive experiments on three public benchmark datasets demonstrate that our method consistently outperforms state-of-the-art methods. The code is available here.

Multi-modal classification leverages complementary information across diverse data sources to enhance predictive performance. However, real-world scenarios subject to operational constraints, such as sensor failures or privacy restrictions, lead to inconsistent modality availability between training and inference times. To handle missing modalities, prior studies have mainly covered bimodal data setups and focused on designing robust fusion processes. Instead, we adopt a multi-modal co-learning framework that prioritizes inter-modal collaboration rather than multi-modal fusion. Specifically, we consider that any subset of modalities may be absent, without assuming predefined missing-modality patterns, an inference scenario we refer to as missing arbitrary modalities. To address this challenge, we introduce two alternative approaches that leverage information at both feature- and decision-level. Experiments on two multi-modal classification benchmarks demonstrate significant robustness gains in various missing modality conditions. The first method shows more robust behavior under minimal missing conditions, where a single modality is absent, whereas the second performs better under extreme missing conditions, where all-but-one modalities are missing. Our code is available at https://github.com/fmenat/Co4Miss.

Multimodal Federated Learning is often challenged by arbitrary modality missingness and Non-IID data distributions, which lead to severe representation drift and hinder effective collaboration across clients. Existing methods typically rely on generative imputation, external auxiliary data, or isolated unimodal training to bridge modality gaps, often incurring substantial communication and computational costs as well as potential privacy risks. To address these limitations, we propose FedTaste, a parameter-efficient framework for topology-aware structural transfer in Multimodal Federated Learning with missing modalities. Instead of aligning fragile first-order features, FedTaste focuses on more stable group-level semantic relations. Specifically, FedTaste leverages frozen foundation models to extract a joint multimodal topology from full-modality clients, which is then consolidated by the server into a global structural blueprint. To adapt clients with missing modalities, we introduce Modality-Adaptive Structural Prompts together with spectral consistency regularization, enabling lightweight branch-specific adaptation that aligns local partial representations with the shared blueprint. In this way, FedTaste avoids explicit modality imputation while preserving shared semantic structure across clients. Extensive experiments demonstrate that FedTaste consistently achieves superior performance across multiple datasets and challenging Non-IID settings, while substantially reducing communication overhead compared with existing methods.

RGB-D semantic segmentation has achieved remarkable progress, yet most models assume that RGB and depth are always available. In practice, failures or occlusions of surveillance sensors often remove one modality. Although RGB or depth alone can contain sufficient cues, models trained only on full-modality inputs fail to exploit the remaining modality once one is missing, causing severe degradation. We tackle this issue with a simple continued-training paradigm, \emph{Condition Dropout (ConD)}, which mitigates degradation while preserving full-modality accuracy. Starting from a pretrained RGB-D model, ConD adds a second stage that randomly simulates complete, RGB-missing, and depth-missing inputs, freezes the original encoders, and trains copied encoders with zero-initialized feature injection. Experiments on NYU-Depth V2 and SUN RGB-D show that ConD improves robustness under missing modalities and even yields slight gains when modalities are complete. Our code will be made publicly available upon acceptance.

Magnetic resonance imaging comes in various modality contrasts that provide complementary anatomical and pathological information. Complete multimodal acquisitions are often unavailable due to time and protocol constraints. This leads to real-world datasets with missing modalities, where conventional medical image translation methods are typically limited to fixed source-target settings or require retraining for each observed source-target pair. We propose a unified framework that formulates missing-modality generation as a linear inverse problem under a joint distribution and solves it via posterior sampling with a flow matching model. By learning a joint prior over the complete modality set, our method can reconstruct arbitrary missing modalities at inference time by guiding the sampling trajectory to enforce measurement consistency with observed modalities. We further mitigate inter-modality error propagation in multi-target generation by adopting a many-to-one sampling strategy. Experiments on BraTS and IXI datasets show that our method achieves the best performance over baselines across most missing-modality scenarios. In downstream tumor segmentation, synthesized images from our method result in higher segmentation performance, indicating better preservation of clinically relevant structures.

Existing methods for multimodal sentiment analysis (MSA) under missing modalities usually follow a repair-first paradigm. We revisit this assumption and ask: \emph{should every missing modality be repaired?} A per-sample oracle analysis shows the answer is not always: full-modality input is optimal for only a small fraction of samples, and every modality subset is preferred by some samples. These results suggest that adding or repairing modalities may not always improve prediction, and that the utility of each modality is sample-dependent. Building on this finding, we propose \textbf{S}ufficiency-\textbf{I}nformed \textbf{E}vidential \textbf{V}al\textbf{vE} (\textbf{SIEVE}) that turns ``whether to repair'' into an explicit, learnable decision at the sample level. SIEVE compares a direct prediction branch with a repair branch, derives an empirical sufficiency signal from their per-sample loss gap, and routes each input through an evidential gate that jointly models sufficiency and its epistemic uncertainty. SIEVE is repair-agnostic: it operates as a plug-and-play decision on top of any explicit or implicit repair module, without modifying its internal design. Experiments on CMU-MOSI and IEMOCAP show that SIEVE consistently improves representative repair backbones across evaluated missing rates, and approaches the per-sample dual-branch achievable optimum.

Reliable autonomous navigation in unstructured off-road environments remains a critical unsolved challenge due to extreme terrain diversity, drastic illumination variations and acute sensor degradation. Recent developments have approached the problem as a traversability costmap estimation or visual navigation task. However, many exhibit heavy reliance on RGB modality, leading to poor performance in varied illumination such as glares, shadows or low ambient light. Achieving robust generalization in such conditions requires integrating modalities that provide supplementary scene information. Such multi-modal methods suffer from a rigid dependency on the presence of near-perfect sensor inputs, leaving them unable to robustly handle sensor degradation or individual modality failure. To address these limitations, we introduce MAMMOTH (MAsking Multi-Modal inputs for Off-road Traversability Heuristic-informed navigation), a unified end-to-end navigation policy for robust off-road visual-goal-conditioned navigation and undirected exploration. Specifically, MAMMOTH efficiently fuses multi-modal observations (RGB, Thermal, 3D Pointcloud and Ego Velocity) and is trained with a modality dropout scheme, enabling it to generalize to missing modalities at inference time. Furthermore, we employ a diffusion policy to learn the joint conditional probability distribution of physically-grounded trajectories and a intrinsic traversability heuristic. MAMMOTH utilizes this heuristic to prefer safer, smoother trajectories. We validate MAMMOTH through extensive real-world robot experiments in distinct off-road environments, including night-time operation. Our results demonstrate superior performance, with significant improvements in collision avoidance, terrain-aware planning and generalization to missing modalities. The code and dataset used for this work will be made publicly available.

Prototype-based Incomplete Multi-view Clustering has recently attracted increasing attention by exploiting prototypes as semantic anchors for missing-view imputation. However, existing approaches are still limited in three aspects. First, they typically focus on enforcing cross-view prototype consistency, while ignoring view-specific information embedded in prototypes, thus limiting multi-view expressiveness. Second, most methods rely on instance-level contrastive learning that only aligns paired samples across views, failing to preserve cluster-level relational structures. Third, missing-view imputation is usually performed using global prototypes alone, without considering local geometric neighborhood structures, leading to inaccurate recovery of missing representations. To address these limitations, we propose a novel framework termed Structure-aware PrOtotype disentanglement foR incomplete multi-view clusTering (SPORT), which explicitly disentangles shared and view-specific components of prototypes while preserving cluster-level relational structures. Specifically, we decouple prototypes into orthogonal shared and view-specific components, aligning only shared components to capture consensus semantics while de-correlating view-specific components to preserve complementary information. Meanwhile, a structure-aware contrastive learning mechanism is incorporated to explicitly model cluster-level relationships during cross-view representation learning. Furthermore, a hybrid imputation strategy integrates global prototype matching with local neighborhood matching, enabling joint exploitation of semantic prototypes and manifold structures for missing-view recovery. Extensive experiments on six benchmark datasets show that SPORT achieves superior performance over state-of-the-art methods under various missing rates.

Multimodal learning robust to missing modalities is essential for real-world applications. Existing methods mainly focus on inter-modality missing, where entire modalities are absent, while overlooking intra-modality degradation, where modalities are present but severely corrupted. In practice, these two types of missing often coexist, making existing approaches ineffective. To address this limitation, we propose General Incomplete Multimodal Learning (GIML), a unified framework that simultaneously handles both inter-modality missing and intra-modality degradation through dynamic quality perception. Specifically, GIML models heterogeneous missing patterns as continuous modality information degradation, enabling degradation-aware adaptive fusion. To achieve reliable quality perception, we introduce a Noise-aware Quality Estimator that learns the mapping from corrupted features to noise intensity through controlled noise injection. Furthermore, we propose a Noise-Semantic Decoupled module that separates semantic information from noise interference. This improves robustness and generalization to unseen corruption patterns. Extensive experiments across datasets with diverse modality types demonstrate the effectiveness and generality of GIML. Code is available at: https://github.com/Yu-Five/GIML.

In this paper, we address the problem of multimodal federated learning with missing modality. Existing methods utilize an additional public dataset or perform naive feature synthesis that is based solely on the available modality. To address these limitations, we propose ProMoE-FL, a Prototype-conditioned Mixture-of-Experts framework for robust missing-modality feature synthesis in multimodal federated learning. ProMoE-FL builds a global client-aware prototype bank that captures clinically meaningful modality priors across institutions. Our Mixture of Experts is conditioned on these prototypes and modality indices to enable direction-aware expert routing for dynamically synthesizing missing features. We perform extensive quantitative and qualitative evaluations on four public chest X-ray datasets (MIMIC-CXR, NIH Open-I, PadChest, and CheXpert) and demonstrate that ProMoE-FL consistently outperforms state-of-the-art methods in both homogeneous as well as the more challenging heterogeneous settings.

Large-scale multimodal models (LMMs) have achieved superior performance in visual recognition by synergizing information across diverse, massive-scale paired modalities. In real-world scenarios, however, missing-modality inputs are ubiquitous, causing models optimized for modality-complete data to exhibit precipitous performance degradation. Existing research has introduced prompt learning to mitigate this issue, typically by generating dynamic prompts from instance-level features, regardless of whether the input modalities are complete or partially absent. However, such input-conditioned strategies are hindered by the escalating unreliability of instance-level features; as higher missing rates increase the proportion of incomplete modalities, the resulting instability in prompt learning limits the model's performance. To address this limitation, we hypothesize that learnable latent prompts themselves encapsulate stable, modality-intrinsic priors that are decoupled from corrupted inputs. Consequently, we propose a novel paradigm: Learning from Reliable Latent Prompts. Unlike prior methods, we model input-agnostic learnable prompts as stable latent anchors that enable robust guidance and effective cross-modal knowledge compensation, even under extreme missing rates (e.g., 90%). Empirical results across three benchmark datasets demonstrate that our "learn-from-latent-prompts" approach achieves state-of-the-art performance across a wide range of missing-modality scenarios. Extensive experiments further confirm the effectiveness of this paradigm in providing a robust solution to the missing-modality problem.

Multimodal MRI is essential for accurate brain tumor segmentation. However, acquiring all modalities at inference is often challenging in practice, which causes intrinsic uncertainty due to unavoidable information loss. Without modeling this uncertainty, existing methods encode incomplete evidence into deterministic representations that appear plausible but lack reliability. In this regime, we propose a probabilistic representation framework that models representations as Gaussian distributions, where their mean captures task information and their variance measures uncertainty from missing evidence. To make variance reflect information deficiency, we regularize the mean from each partial configuration toward its full-modality counterpart, while scaling the variance with the discrepancy between their aligned means. We further introduce a set-inclusive strategy that exploits the hierarchical structure of modality subsets and enforces an ordering constraint to maintain their consistent uncertainty relationships. Extensive experiments on BraTS 2018 and 2020 demonstrate that our approach offers superior performance over baselines across diverse missing-modality scenarios. Code and model checkpoint are available at https://github.com/atlas-sky/SIUM.

Recent multimodal survival prediction models have demonstrated strong predictive performance by leveraging complementary information across modalities. However, such models generally assume data completeness and exhibit limited robustness toward missing modalities, which are frequently encountered in real-world clinical settings. We propose the Evidential Missing Modality Survival Fusion (EMMS) model for multimodal survival prediction under missing modalities. EMMS offers a straightforward, computationally effective approach to survival analysis without requiring a generative phase for missing data. By employing Dempster-Shafer theory and Gaussian Random Fuzzy Numbers for multimodal decision fusion, it considers both aleatoric and epistemic uncertainty alongside modality reliability for fusion. Moreover, the model treats missing modalities as vacuous evidence, preventing interference with available inputs and naturally reflecting increased uncertainty and calibrated predictions. Extensive experiments on four cancer datasets demonstrate state-of-the-art performance while providing calibrated and interpretable uncertainty estimates under incomplete multimodal observations, without introducing additional computational overhead.

This paper addresses the missing-modality challenge in multi-modal learning by introducing Unsupervised Learning for Missing Modalities in Multi-Modal Learning (UL4M4), a flexible framework that imputes missing feature embeddings in a task-independent manner before supervised prediction. We propose modality-specific normalization and a novel partial-modality distance metric to enable fair clustering of incomplete observations, capturing cross-modal structures while preserving scale-invariance across varying dimensionalities and modality counts. Cluster centers from this unsupervised stage guide an iterative greedy imputation process for any missing modalities during training or inference, supporting arbitrary numbers of modalities and arbitrary missing patterns per sample. The imputation module is lightweight, uses frozen encoders, and decouples from the downstream task, allowing easy integration with any fusion/prediction architecture. Extensive experiments under diverse and highly incomplete regimes demonstrate UL4M4's robustness, achieving, to the best of our knowledge, the first consistent F1-Micro scores above 0.7 on challenging missing configurations even when more than 50% of modality slots are missing. Results are also stable across cluster sizes and significantly outperform state-of-the-art baselines. Code is available here: https://github.com/h-ismkhan/Multimodal-Learning-with-Missing-Modalities-via-Unsupervised-Learning.

Robotic systems perceive the world through multiple input modalities -- including visual camera streams and natural language instructions -- and must select appropriate actions based on these signals. However, assuming the permanent availability of all input devices is unrealistic, as sensors may fail, become occluded, or drop out entirely during deployment. Robust handling of such missing-modality scenarios is therefore essential for real-world robot operation. This paper introduces RL4IL, a reinforcement learning guided method for imitation learning that selects the most suitable action for a given observation by identifying the most relevant expert demonstrations from a training library. A reinforcement learning policy, trained via Proximal Policy Optimisation over Breadth-First Search candidate sets, ranks candidate demonstrations and a soft cross-attention fusion head aggregates their action signals to produce the final prediction. When a modality is missing at inference time, a dedicated per-modality RL retrieval policy identifies donor demonstrations from the training library, and a soft imputation head reconstructs the missing embedding via cross-attention over the top-ranked donors -- without requiring any retraining of the system. Experiments on three LIBERO benchmark suites demonstrate that RL4IL substantially outperforms state-of-the-art imitation learning methods under sensor dropout conditions, while requiring no policy network training. The code can be found at https://github.com/h-ismkhan/Reinforcement-Learning-via-kNN-for-Robotic-Learning-with-Missing-Camera

Learning with missing modalities is a fundamental challenge in multimodal robot learning, as real-world robotic systems often operate in environments with incomplete sensor data. Attention-based models are appealing for processing multimodal data because they can handle multiple modalities with a single backbone network. However, most multimodal models assume that all modalities are available during both training and inference, limiting their applicability in robotic perception and decision-making. In this paper, we introduce a multimodal model designed to handle missing modalities during both training and inference. The model is formulated as a conditional variational autoencoder (CVAE) and incorporates a transformer-based architecture that leverages attention mechanisms to learn a unified, fixed-dimensional representation, even when some modalities are missing. We show that our proposed model can be trained with missing modalities while approximating a robust representation of all modalities. We evaluate our approach on five multimodal datasets across two robot learning tasks: human trajectory prediction and robot manipulation forecasting. Experimental results demonstrate that our model effectively learns from incomplete data and is superior to prior multimodal fusion approaches.

We study multimodal learning under missing modalities, with particular motivation from bioscience applications in which heterogeneous modalities are often only partially available when decisions need to be made. We propose Latent World Recovery (LWR), a framework built on two key ideas: (i) modality-specific embeddings from different modalities are aligned in a shared latent space, and (ii) a unified representation is constructed by fusing only the embeddings of the modalities that are actually available at both training and inference time. Rather than imputing missing modalities or requiring a fixed modality set, LWR treats each modality as a partial perception of an underlying latent state and performs availability-aware representation learning directly from the observed modalities. This combination of neighbor-based latent alignment and availability-aware modality fusion enables robust multimodal prediction under partial observation, while avoiding error propagation from explicit reconstruction of missing modalities. We evaluate the proposed framework on real-world incomplete multi-omics benchmarks and demonstrate that it provides an effective approach to downstream tasks such as cancer phenotype classification and survival prediction.

Multimodal federated graph learning (MM-FGL) aims to collaboratively learn from decentralized graphs with text and images. However, real-world clients may not share a common modality basis: a visual-search client may contain image--interaction graphs but no seller descriptions, while a catalog client may provide text but no product images. We refer to this practical setting as client-level modality deficiency. Unlike random instance-wise missingness, a deficient client lacks the local semantic basis needed to reconstruct the absent modality. More importantly, in graph learning, incomplete representations initialize message passing, so imputation errors can be filtered, mixed, and amplified by the receiving topology. To address this gap, we propose \textbf{PRISM} (\textbf{P}roactive \textbf{R}etrieval and \textbf{I}mputation via \textbf{S}tructural \textbf{M}eta-prompting), a topology-aware federated cross-modal imputation framework. Rather than reconstructing the missing modality solely from local observations, PRISM recovers missing-modality semantics from the federation and introduces them into local graph propagation under topology-aware control. Experiments on six multimodal graph datasets across graph-centric and modality-centric tasks show that PRISM consistently improves modality-deficient clients, outperforming state-of-the-art baselines by \textbf{4.48}% on average.

Multimodal clinical learning is increasingly important for integrating diverse patient data, including imaging, text, and personalised health records. However, it faces two fundamental challenges: i) modality missingness, where arbitrary subsets of modalities are unavailable at a given patient visit, ii) longitudinal dynamics, where the diagnostic significance of an observation depends on the patient's evolving disease trajectory over time. Existing methods address these challenges in isolation: missing-modality frameworks treat each visit as an independent static snapshot and discard temporal context, while longitudinal models often assume complete modality availability and degrade under systematic modality incompleteness. We propose LongMoE (Longitudinal Mixture-of-Experts), the unified framework to jointly address both challenges. LongMoE combines a context-aware imputation module with an attentional tokenization module that captures frequency-domain temporal patterns across irregular visit sequences, a trajectory-aware encoder for modeling disease progression, and context-conditioned Sparse MoE routing for patient-specific expert selection. Experiments on ADNI, OASIS-3, and MIMIC-IV show that LongMoE improves robustness under missing or weak contemporaneous modalities and remains competitive in full-modality settings, establishing a strong foundation for longitudinally-aware multimodal clinical learning.

Modern medicine relies on heterogeneous data sources spanning radiology, pathology, text reports, and structured clinical information. However, real-world patient data are frequently incomplete, with missing or sparsely acquired modalities, limiting the effectiveness of standard multimodal fusion approaches. To this end, we propose the Multimodal Flexible Redundancy-aware decomposed GAted Learning (Multi-FRuGaL) framework, a decomposition-aware, adaptive gated intermediate-fusion framework that performs modality-level representation learning under missing data. Multi-FRuGaL integrates per-modality encoders with a signal decomposition layer, an input-conditioned gating network, and an information-aware fusion objective to separate redundant from modality-specific complementary signals, selectively upweighting informative modalities and suppressing redundant or noisy inputs, and remaining well-defined even when multiple modalities are absent. We evaluate Multi-FRuGaL on two multimodal head and neck cancer cohorts: the HANCOCK challenge dataset (N = 763) comprising five modalities and two prognostic endpoints (5-year survival and 2-year recurrence), and the HECKTOR challenge dataset (N = 588) comprising three modalities for human papillomavirus (HPV) status classification. Multi-FRuGaL consistently achieves higher mean performance than the evaluated baselines across multiple tasks, improving AUC from 0.601 to 0.8496 for survival, from 0.672 to 0.8102 for recurrence, and achieving 0.975 AUC for HPV prediction on HECKTOR. For survival analysis, it further achieves a concordance index of 0.6814 for overall survival, 0.7421 for recurrence-free survival, and 0.7143 for progression-free survival on HANCOCK, and 0.7203 for recurrence-free survival on HECKTOR. Qualitative analyses further show that Multi-FRuGaL learns discriminative and robust multimodal representations, even under severe missing-modality conditions.

In healthcare, multimodal time series tasks often operate on incomplete observations in practice, for example when ECG segments are lost because electrodes detach or an entire respiratory channel is unavailable during overnight monitoring. Such missingness typically appears in two structurally distinct patterns: within-modality missing, where values are absent within an otherwise observed modality, and modality-level missing, where an entire modality is unavailable. Existing methods typically represent unobserved data implicitly through masks or missing embeddings, without learning instance-specific missing information, and most are designed for only one missingness pattern. A natural approach is to explicitly estimate the missing data; however, existing imputation methods treat missingness uniformly despite their different structural priors, and the imputation process is often isolated from downstream tasks, preventing downstream tasks from guiding imputation toward more informative representations. To address these limitations, we present PAMF, a multimodal time-series framework that explicitly handles different missingness patterns while coupling imputation with downstream prediction through prior-aware flow matching and weight sharing. Specifically, the method initializes the flow-matching source state with type-specific priors to distinguish two missing types. It further connects imputation and classification through architecturally matched encoders with weight sharing, transferring task-relevant representations into the imputation process. Experiments on multiple multimodal healthcare time-series benchmarks show that the proposed method achieves the strongest overall downstream performance across diverse datasets and missing settings compared with existing baselines.

Time series foundation models (TS-FMs) aim to learn generalizable temporal representations that can be adapted to a wide range of downstream tasks. In real-world multimodal settings, time series are frequently affected by temporal misalignment and partial modality missingness, where different modalities are observed at heterogeneous time scales or are partially absent. Existing approaches typically rely on naive imputation or masking strategies, which fail to account for cross-modal dependencies and often lead to misaligned or degraded representations. We propose TRACE, a conditional estimation paradigm for multimodal time series foundation model pipelines under missingness and irregular sampling, allowing incomplete target modalities to be systematically inferred from available auxiliary modalities. We evaluate TRACE on diverse multimodal benchmarks spanning healthcare and affective computing, including the MIMIC-IV clinical dataset and the CMU-MOSI and CMU-MOSEI benchmarks for multimodal sentiment analysis. Across a range of downstream prediction tasks and missing-modality settings, TRACE consistently outperforms prior multimodal fusion approaches, demonstrating improved robustness to severe modality missingness and more reliable cross-modal representations.

Missing value imputation is a fundamental task in machine learning, with most existing methods assuming that all missing entries correspond to unobserved regular values. In many real-world datasets, however, missingness may arise from two distinct sources: some entries are meaningfully missing (intrinsically absent and semantically valid), while others are missing due to the observation process and should be imputed. We formalize this distinction as a selective imputation problem, where the goal is to jointly infer which missing entries should be preserved and which should be recovered. To address this challenge, we propose Diff-Joint, a diffusion-based framework that jointly models tabular data together with a latent missingness mask. The method alternates between conditional sampling and uncertainty-aware aggregation to iteratively refine both imputed values and missingness labels. Empirical results on synthetic and real-world datasets demonstrate that Diff-Joint effectively identifies meaningfully missing entries while achieving competitive imputation accuracy and improved downstream task performance.

Deploying multimodal systems in real-world environments often entails handling modality-missing scenarios, where one or more modalities are unavailable. While recent studies address this challenge for the general Multimodal Transformer (MT) architecture via prompt tuning, we identify a fundamental limitation in these methods: the Implicit Modality-Reduction bottleneck. By conditioning prompts solely on the observed modalities, they inadvertently restrict the reasoning scope of MTs to the modality-reduced subspace, cutting off access to the latent information sources of the missing modalities. To overcome this limitation, we propose AOEPT, which pioneers a novel modal-contextualized prompting fashion. Specifically, we introduce lightweight Modal-Contextualized Prompts (MCPs) that distill global modality-wise priors from training data, serving as latent repositories of the information sources for missing modalities. Conditioned on the remaining modalities, these MCPs are instantiated into instance-aware prompts that selectively augment missing-modality information for each sample, thereby restoring the reasoning scope of MTs beyond the observed-modality-only subspace. Experiments across various multimodal benchmarks and backbones confirm the strong performance of AOEPT, with minimal computational overhead.

Accurate brain tumor segmentation using multi-parametric MRI is critical for effective treatment planning. However, in clinical settings, complete acquisition of all MRI sequences is not always possible. The absence of certain MRI modalities results in substantial performance degradation in existing segmentation methods, which typically rely on naive feature concatenation or direct fusion strategies. To address this limitation, we propose a novel segmentation model D3Seg which is designed to maintain stable performance under missing-modality settings. D3Seg introduces Multi-hop Modality Graph Fusion (MMGF) to model higher-order inter-modality dependencies, a lightweight diffusion-based imputation mechanism to compensate for missing T1ce and FLAIR feature representations in latent space, and probability-space decision refinement to mitigate dominant-class overconfidence and improve delineation of underrepresented tumor subregions. We evaluate the proposed D3Seg model on BraTS 2023 Glioma as the primary benchmark and further test it on a subset of the external BraTS 2023 Meningioma cohort to assess generalization across tumor pathologies. The results are compared with the state-of-the-art models under different missing-modality conditions. The proposed model achieves approximately 1.5-2.0% Dice improvement on enhancing tumor (ET) and around 1.0% on tumor core (TC) across multiple missing-modality configurations compared to the current state-of-the-art model on BraTS Glioma dataset. Cross-cohort evaluation on BraTS Meningioma dataset demonstrates the generalizability of the proposed model, showing consistent improvements in the challenging TC and ET regions, with approximately 1.5-3.0% and 1.5-6.5% gains respectively across several missing-modality configurations.

Multimodal semantic segmentation benefits remote sensing analysis by combining complementary information from different sensor modalities. In real-world remote sensing applications, one or more modalities may be unavailable due to sensor failures, adverse atmospheric conditions, or data acquisition problems. Even with pretrained multimodal representations and existing fine-tuning or adaptation strategies, performance may remain limited because all modality availability scenarios are typically treated as equally informative during training. In this paper, we propose a novel training strategy that learns a scenario sampling distribution directly from the pretrained latent space. Instead of relying on uniform random modality dropout, the proposed method guides fine-tuning toward more informative modality availability scenarios. More specifically, we quantify the effect of each scenario independently based on the distortion it induces in the shared latent representation. We then capture scenario relations using a radial basis function kernel and derive refined scenario scores through a regularized kernel smoothing. These scores are then converted into a probability distribution during scenario sampling for fine-tuning. We evaluate this strategy on three remote sensing image sets, namely DSTL, Potsdam, and Hunan, using CBC-SLP, CBC, and CMX backbones. The experimental results with different image sets and backbones show that our method outperforms standard fine-tuning and LoRA-based adaptation. These findings suggest that the pretrained latent representation can serve as an effective basis for sampling during missing modality fine-tuning. Code is available at https://github.com/iremulku/Latent-Space-Guided-Scenario-Sampling

Multimodal sentiment analysis relies on textual, acoustic, and visual signals, yet real-world data often suffer from modality missing and quality imbalance. Existing methods generate features for modality missing from available ones, but differences in expression mechanisms and sentiment dynamics across modalities may cause the generated features to deviate from true distributions and mislead prediction. In addition, unreliable modalities may dominate fusion, resulting in representation shift across modality combinations and unstable sentiment representations. To address these challenges, we propose a two-level reference alignment framework. The framework introduces stable references at the feature representation and sentiment decision levels to improve robustness under modality missing. First-level reference alignment leverages complete-modality samples to constrain representations and align different modality combinations into a shared sentiment space. Second-level reference alignment enforces cross-modal consistency at the decision level by suppressing unreliable modalities through prototype retrieval and voting. As a result, the framework maintains stable and reliable sentiment predictions under diverse missing-modality patterns. Experiments on CMU-MOSI and CMU-MOSEI show consistent improvements across various missing-modality settings. Under full-modality input, the proposed method achieves state-of-the-art performance, with ACC of 86.28% and 85.88%, and F1 of 86.24% and 85.86%.

Multimodal magnetic resonance imaging (MRI) is crucial for brain tumor segmentation, with many methods leveraging its four key modalities to capture complementary information for effective sub-region analysis. However, the absence of several modalities is very common in practice, leading to severe performance degradation in existing full-modality segmentation methods. Limited by the structured data model, recent works often adopt a multi-stage training strategy for full-modality and missing-modality scenarios, which increases training costs and inadequately addresses the interference of miss. In this work, we propose a graph-based one-stage framework for robust brain tumor segmentation with missing modalities. Specifically, we introduce modality-specific virtual nodes that serve as supplementary information sources to compensate for missing modalities. To enhance model robustness against arbitrary modality combinations, we leverage the inherent flexibility of graph networks to devise a dynamic connection strategy. This mechanism dynamically adjusts the adjacency matrix based on modality availability, preserving beneficial information flow while mitigating interference effects caused by missing modalities. Furthermore, we enhance the graph network through heterogeneous weight matrices, enhancing its adaptability to multimodal scenarios. Extensive experiments on the BRATS-2018 and BRATS-2020 datasets demonstrate that our method outperforms the state-of-the-art methods on almost all subsets of incomplete modalities.

Multimodal clinical prediction faces three challenges: multiple foundation models (FMs) with complementary strengths per modality, pervasive missing modalities at training and test time, and sample-specific variation in modality contributions. We introduce MedMIX, a multimodal framework that combines intra-modality expert fusion, learned inter-modality fusion, and training-only large--small model collaboration for robust medical prediction under incomplete modalities. Within each modality, MedMIX aggregates complementary embeddings from multiple small expert models; across modalities, it performs learned fusion over available modalities; and during training, it leverages large teacher models to improve deployed representations without additional inference cost. Across three heterogeneous benchmarks (OpenI, MIMIC-IV-MM, and MMIST-ccRCC), MedMIX achieves consistently strong performance while remaining robust under controlled missing-modality perturbations, and further demonstrates sustained robustness under cross-cohort shift on MIMIC-III. These results highlight MedMIX as a practical framework that unifies within-modality expert collaboration, sample-specific cross-modality fusion, and efficient large--small model collaboration while remaining robust to incomplete modalities.

Multimodal physiological data powers clinical AI systems from intensive care units to wearable devices, but sensors routinely fail in practice. Two failure modes are common: modality missing, where an entire channel is absent, and within-modality missing, where a contiguous time segment is lost. No existing benchmark evaluates multiple fusion architectures under both failure modes at controlled severity levels across diverse clinical datasets. We present MuteBench, a benchmark covering 9 datasets from 7 clinical domains, 6 fusion architectures, and 2 missing-data modes over 125,000 samples. Through this benchmark, we find that architecture family is the strongest predictor of robustness, outweighing parameter count. Channel-independent models tolerate modality missing well but can be sensitive to within-modality missing, especially on short sequences. Curriculum modality dropout protects reliably only up to the maximum dropout rate used in training. We also find that channel count, sequence length, and modality alignment jointly determine which failure mode poses the greater threat. Finally, a PTB-XL case study suggests that diffusion-based imputation can improve downstream classification under within-modality missing, with the largest gains for models whose expert routing is most sensitive to corrupted inputs, though broader validation across datasets remains an open direction. MuteBench provides practitioners with concrete guidance for both selecting existing architectures and informing the design of future robust multimodal fusion methods.

Missing modalities are prevalent in real-world Alzheimer's disease (AD) assessment and pose a significant challenge to multimodal learning, particularly when the distribution of observed modality subsets differs between training and deployment. Such missingness pattern mismatch induces a conditional representation shift across modality subsets. Existing approaches that rely on implicit imputation or modality synthesis often fail to explicitly model modality availability and uncertainty, leading to overconfident dependence on synthesized features, reduced robustness, and miscalibrated uncertainty estimates. To address these limitations, we propose PRA-PoE, an incomplete multimodal learning framework that is equipped with Prototype-anchored Representation Alignment (PRA) and an Uncertainty-aware Product of Experts (UA-PoE) fusion mechanism. First, PRA uses learnable global prototypes and availability-conditioned tokens to encode modality availability, distinguish observed from missing modalities, re-synthesize features for missing modalities, and adaptively refine observed representations to align latent spaces across modality subsets, with the goal of reducing representation shift under varying missingness patterns. Second, UA-PoE models each modality as a Gaussian expert and performs closed-form Product of Experts fusion, where experts with higher uncertainty are automatically down-weighted via lower precision, improving uncertainty reliability. We evaluate PRA-PoE under a clinically realistic protocol by training with naturally missing data and testing on all non-empty modality combinations. PRA-PoE consistently outperforms the state-of-the-art across datasets, achieving a 5.4% relative improvement in average accuracy on ADNI and a 10.9% relative gain in average F1 on OASIS-3 over the strongest baseline across all non-empty modality subsets.

Wearable devices enable continuous health monitoring from multimodal signals, but real-world deployment is hindered by limited labeled data and pervasive sensor incompleteness. While large-scale self-supervised pretraining reduces label dependence, most existing methods assume full modality availability. Current approaches for handling modality missingness often reconstruct entire absent signals, which can encourage hallucinating modality-specific details that are not inferable from the observed sensor signals and degrade robustness. We propose VCR, a self-supervised framework that learns to extract valid representations robust to modality missingness. VCR employs an orthogonal tokenizer to enforce strict orthogonal disentanglement by rectifying latent manifolds and applying a geometric projection, separating each modality into shared semantics and modality-specific residuals. This design preserves complete information integrity while serving as a structural foundation for robust learning under modality missingness. The resulting tokens are processed by a missing-aware mixture-of-experts backbone that adapts to varying patterns of modality availability. By constraining the objective to reconstruct only the shared components of missing modalities, VCR effectively mitigates hallucinations of non-inferable modality-specific details. Across multiple health monitoring tasks, VCR consistently improves performance and robustness under full, single-missing, and multiple-missing modality settings compared with strong supervised and self-supervised baselines.

Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete modality availability, an assumption that rarely holds in real-world clinical settings where entire modalities and individual features are frequently missing. In this work, we propose a multimodal transformer framework for joint vision-tabular learning explicitly designed to operate under pervasive modality missingness, without relying on imputation or heuristic model switching. The architecture integrates three components: a vision, a tabular, and a multimodal fusion encoder. Unimodal representations are weighted through learnable modality tokens and fused via intermediate fusion with masked self-attention, which excludes missing tokens and modalities from information aggregation and gradient propagation. To further enhance resilience, we introduce a modality-dropout regularization strategy that stochastically removes available modalities during training, encouraging the model to exploit complementary information under partial data availability. We evaluate our approach on the MIMIC-CXR dataset paired with structured clinical data from MIMIC-IV for multilabel classification of 14 diagnostic findings with incomplete annotations. Two parallel systematic stress-test protocols progressively increase training and inference missingness in each modality separately, spanning fully multimodal to fully unimodal scenarios. Across all missingness regimes, the proposed method consistently outperforms representative baselines, showing smoother performance degradation and improved robustness. Ablation studies further demonstrate that attention-level masking and intermediate fusion with joint fine-tuning are key to resilient multimodal inference.

Addressing missing modalities is an important challenge in multimodal image analysis and often relies on complex architectures that do not transfer easily to different datasets without architectural modifications or hyperparameter tuning. While most existing methods tackle this problem in feature space by engineering representations that are robust to missing inputs, we instead operate in weight space. We propose LARGO, a hypernetwork that compresses the $2^N-1$ dedicated missing-modality models into a single network by modelling the convolutional weights using the Canonical Polyadic (CP) tensor decomposition. Extensive experimental validation on BraTS 2018 (4 modalities, 15 scenarios) and ISLES 2022 (3 modalities, 7 scenarios) shows that our method ranks first in 47 out of 52 configurations, achieving average Dice improvements of +0.68$\%$ and +2.53$\%$ over state-of-the-art baselines (mmFormer, M$^{3}$AE, ShaSpec, SimMLM). A proof-of-concept experiment on avMNIST suggests that LARGO may extend beyond medical imaging to heterogeneous non-medical modalities.

Partially-observed time series (POTS) is ubiquitous in real-world applications, yet most existing toolchains separate missing-value handling from downstream learning, which limits reproducibility and overall performance. This tutorial introduces PyPOTS, an open-source Python ecosystem for end-to-end data mining and machine learning on POTS. We present practical workflows spanning missingness simulation, data preprocessing, model training, and evaluation across core tasks, including imputation, forecasting, classification, clustering, and anomaly detection. The tutorial consists of two parts: Part I emphasizes hands-on application for practitioners through unified APIs and benchmark-oriented experiments. Part II targets developers and researchers, focusing on extending PyPOTS with custom models, domain-specific constraints, and contribution-ready engineering practices. Participants will gain both conceptual understanding and implementation experience for building robust, transparent, and reusable POTS pipelines in research and production settings. PyPOTS is publicly available at https://github.com/WenjieDu/PyPOTS

Multimodal Federated Learning (MMFL) enables privacy-preserving collaborative training, but real-world clinical applications often suffer from within-modality missingness caused by sensor intermittency or irregular sampling. Existing methods implicitly represent unobserved data via architectural alignment or missing embeddings, often failing to recover the true distribution and yielding sub-optimal performance. We propose CondI, a federated framework explicitly addressing this missingness using conditional diffusion models. CondI employs a two-phase training pipeline: first, imputing unobserved temporal components using available multimodal context and conditional embeddings; second, optimizing modality-specific extractors and joint embedding spaces. During inference, imputed raw data pass through trained extractors to generate robust features, providing a holistic representation for downstream tasks. Explicit data imputation ensures models operate on complete semantic structures, significantly enhancing resilience against severe data incompleteness. Experiments on three clinical datasets (PTB-XL, SLEEP-EDF, MIMIC-IV) demonstrate CondI achieves comparable results to state-of-the-art baselines. Code: https://github.com/ZhengWugeng/CondI

Federated cross-modal retrieval faces severe challenges from heterogeneous client data, particularly non-IID semantic distributions and missing modalities. Under such heterogeneity, a single global model is often insufficient to capture both shared cross-modal knowledge and client-specific characteristics. We propose RCSR, a personalization-friendly federated framework that integrates prototype anchoring, retrieval-centric semantic routing, and optional client-specific adapters. Built on a frozen CLIP backbone, RCSR leverages lightweight shared adapters for global knowledge transfer while supporting efficient local personalization. Prototype anchoring helps unimodal clients align with global cross-modal semantics, and a server-side semantic router adaptively assigns aggregation weights based on retrieval consistency to mitigate alignment drift during heterogeneous updates. Extensive experiments on MS-COCO, Flickr30K, and other benchmarks show that RCSR consistently improves global retrieval accuracy and training stability, while further enhancing client-level retrieval performance, especially for clients with incomplete modalities. Code is available at https://github.com/RezinChow/RCSR-Retrieval-Centric-Semantic-Routing.

Multimodal MRI offers complementary information for brain tumor segmentation, but clinical scans often lack one or more modalities, which degrades segmentation performance. In this paper, we propose UniME (Uni-Encoder Meets Multi-Encoders), a two-stage heterogeneous method for brain tumor segmentation with missing modalities that reconciles the trade-offs among fine-grained structure capture, cross-modal complementarity modeling, and exploitation of available modalities. The idea is to decouple representation learning from segmentation via a two-stage heterogeneous architecture. Stage 1 pretrains a single ViT Uni-Encoder with masked image modeling to establish a unified representation robust to missing modalities. Stage 2 adds modality-specific CNN Multi-Encoders to extract high-resolution, multi-scale, fine-grained features. We fuse these features with the global representation to produce precise segmentations. Experiments on BraTS 2023 and BraTS 2024 show that UniME outperforms previous methods under incomplete multi-modal scenarios. The code is available at https://github.com/Hooorace-S/UniME

An active challenge in developing multimodal machine learning (ML) models for healthcare is handling missing modalities during training and deployment. As clinical datasets are inherently temporal and sparse in terms of modality presence, capturing the underlying predictive signal via diagnostic multimodal ML models while retaining model explainability remains an ongoing challenge. In this work, we address this by re-framing clinical diagnosis as an autoregressive sequence modeling task, utilizing causal decoders from large language models (LLMs) to model a patient's multimodal trajectory. We first introduce a missingness-aware contrastive pre-training objective that integrates multiple modalities in datasets with missingness in a shared latent space. We then show that autoregressive sequence modeling with transformer-based architectures outperforms baselines on the MIMIC-IV and eICU fine-tuning benchmarks. Finally, we use interpretability techniques to move beyond performance boosts and find that across various patient stays, removing modalities leads to divergent behavior that our contrastive pre-training mitigates. By abstracting clinical diagnosis as sequence modeling and interpreting patient stay trajectories, we develop a framework to profile and handle missing modalities while addressing the canonical desideratum of safe, transparent clinical AI.

Multimodal emotion and intent recognition is essential for automated human-computer interaction, It aims to analyze users' speech, text, and visual information to predict their emotions or intent. One of the significant challenges is that missing modalities due to sensor malfunctions or incomplete data. Traditional methods that attempt to reconstruct missing information often suffer from over-coupling and imprecise generation processes, leading to suboptimal outcomes. To address these issues, we introduce an Attention-based Diffusion model for Missing Modalities feature Completion (ADMC). Our framework independently trains feature extraction networks for each modality, preserving their unique characteristics and avoiding over-coupling. The Attention-based Diffusion Network (ADN) generates missing modality features that closely align with authentic multimodal distribution, enhancing performance across all missing-modality scenarios. Moreover, ADN's cross-modal generation offers improved recognition even in full-modality contexts. Our approach achieves state-of-the-art results on the IEMOCAP and MIntRec benchmarks, demonstrating its effectiveness in both missing and complete modality scenarios.