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We model the interaction between a user and an AI driven recommendation system. The user initiates the process by conveying preference information through a costly and noisy message. The AI assistant, acting as a Bayesian agent, interprets the user's message to form a posterior belief about their true preferences and make product recommendations. In particular, it determines how many recommendations to present so as to maximize the user's expected utility from their final choice, while accounting for the search cost induced by the size of the recommendation set. We use mutual information based cost functions to model the two distinct costs incurred by the user during the interaction: (i) a communication cost, which increases with the precision of their preference message, and (ii) a search cost, which increases with the size of the recommendation set provided by the AI assistant. We study products and preferences which live in d dimensional space, and ask how the user's expected payoff can be maximized. For large d, we characterize how optimal message precision and recommendation set size depend on the cost parameters, under two distinct distributions from which recommendations can be sampled from the product universe: (i) Bayes' posterior belief, and (ii) an optimized tilted distribution. Under the posterior sampling scheme (i), we identify a hybrid regime, in which an efficient interaction policy requires jointly optimizing the amount of information (in bits) conveyed by the user and the number of recommendations provided by the AI assistant. In the tilted sampling scheme (ii), our results show that the optimal interaction policy uses only one of communication and search, favoring whichever of them is less costly.

Driven by the escalating global burden of mental health conditions, music-based interventions have attracted significant attention as a non-invasive, cost-effective modality for emotion regulation and psychological stress relief. However, current digital music services rely on static preferences and fail to adapt to users' instantaneous psychological states. Furthermore, directly mapping electroencephalography (EEG) to music generation remains challenging due to severe paired-data scarcity and a lack of interpretability. To address these limitations, we propose MindMelody, a fully functional, closed-loop real-time system for EEG-driven personalized music intervention. MindMelody introduces an emotion-mediated semantic bridge. Specifically, a hybrid Transformer-GNN first decodes real-time EEG signals into global Valence-Arousal states and local temporal affect trajectories. These states are then fed into a Retrieval-Augmented Generation (RAG)-equipped Large Language Model (LLM) to formulate structured intervention plans. Subsequently, a novel Hierarchical EEG Controller injects global affect prefixes and local temporal guidance into a pretrained music backbone, enabling fine-grained controllable audio synthesis. Crucially, the system incorporates a continuous feedback loop that updates generation parameters on the fly based on the user's evolving EEG dynamics. Extensive experiments show that MindMelody improves control adherence and emotional alignment, and receives higher perceived helpfulness in a short-term listening setting, suggesting its promise as an adaptive affect-aware music generation framework.

Cross-attention patterns in neural machine translation (NMT) are widely used to study how multilingual models align linguistic structure. We report a systematic artifact in cross-attention analysis of NLLB-200 (600M): non-content tokens - primarily end-of-sequence tokens, language tags, and punctuation - capture 83 percent to 91 percent of total cross-attention mass. We term these "attention sinks," extending findings from LLMs [Xiao et al., 2023] to NMT cross-attention and identifying a causal mechanism rooted in vocabulary design rather than position bias. This artifact causes raw metrics to underestimate content-level similarity by nearly half (36.7 percent raw vs. 70.7 percent filtered), rendering uncorrected analyses unreliable. To address this, we validate a content-only filtering methodology that removes non-content tokens and renormalizes the distribution. Applying this to 1,000 parallel sentences across African languages (Swahili, Kikuyu, Somali, Luo) and non-African benchmarks (German, Turkish, Chinese, Hindi), we confirm the artifact is universal and recover masked linguistic signals: a 16.9 percentage-point gap between teacher-forcing and generation modes, clear language-family clustering in attention entropy, and a hidden Somali paradox linking SOV word order to monotonic alignment. We release our filtering toolkit and corrected datasets to support reproducible interpretability research on multilingual NMT.

Audio-visual quality assessment (AVQA) is essential for streaming, teleconferencing, and immersive media. In realistic streaming scenarios, distortions are often asymmetric, where one modality may be severely degraded while the other remains clean. Still, most contemporary AVQA metrics treat audio and video as equally reliable, causing confidence-unaware fusion to emphasize unreliable signals. This paper proposes MCM-AVQA, a multimodal confidence-aware AVQA framework that explicitly estimates modality-specific confidence and injects it into a dedicated audio-visual mixer for cross-modal attention. The Audio-Visual Mixer utilizes frame-level, confidence-guided channel attention to gate fusion, modulating feature interaction between modalities so that high-confidence streams dominate while unreliable inputs are suppressed, preserving temporal degradation patterns. A multi-head visual confidence estimator turns frame-level artifact probabilities into temporally smoothed, clip-level visual confidence scores, while an audio confidence module derives confidence from speech-quality cues without requiring a clean reference. Experiments on multiple AVQA benchmarks show that MCM-AVQA, and specifically its confidence-guided Audio-Visual Mixer, improve correlation with human mean opinion scores and yield more interpretable behavior under real-world asymmetric audio-visual distortions.

Clinical AI adoption is hindered by the black-box/grey-box nature of high-performing models, which lack the ontological grounding and narrative transparency required for professional-level explainability. We present NEURON, a neuro-symbolic system designed to enhance both predictive reliability and clinical interpretability. NEURON integrates SNOMED CT ontology-informed structural representations with machine learning models to bridge the gap between raw data and medical nomenclature. To facilitate human-aligned interaction, the system utilizes a Retrieval-Augmented Generation (RAG) grounded LLM layer to synthesize SHAP feature attributions and patient-specific clinical notes into coherent, natural-language explanations. Validated on the MIMIC-IV dataset for Acute Heart Failure mortality prediction, NEURON improved the AUC from 0.74-0.77 to 0.84-0.88 and significantly outperformed raw SHAP visualizations in human-aligned metrics (0.85 vs. 0.50). Our results demonstrate that NEURON offers a robust, scalable engineering solution for deploying trustworthy, human-centered connected health applications.

Reliable real-time 3D shape sensing is essential for robust control and interpretation of deformable systems during motion. Existing vision-based approaches require line-of-sight and complex instrumentation, limiting operation in occluded and space-constrained settings. Here, we introduce a scalable, skin-like sensor that reconstructs its continuous 3D deformation in real time from distributed strain measurements. The device embeds a 2D array of mirror-stacked, printed oxidized eutectic gallium-indium (o-EGaIn) strain gauges within an elastomeric film to measure off-neutral-axis strains. Combined with a mechanics-informed observation model and a fast optimization routine, the system estimates local curvature, elongation, offset, and orientation under concurrent stretching, bending, and indentation, enabling reconstruction of complex surfaces. A 5-by-5 array with a 12 mm pitch achieves a mean surface reconstruction error of 0.62 mm with 0.1s latency across all tested scenarios. When conforming to complex surfaces, the sensor provides fast 3D shape mapping of the underlying geometry. Demonstrations involving palm gesturing, finger indentation, and contact-induced balloon deformation highlight utility for epidermal motion tracking, haptic interaction, and intraoperative monitoring.

Quantum cognition often explains order effects, contextuality, and violations of the law of total probability by replacing classical probability with quantum probability on a fixed event structure. This paper proposes a different interpretation: quantum probability is the fixed-spacetime projection of contextual spacetime formation under finite-state requirements. The framework begins not with time, space, objects, or probabilities, but with requirements such as finite representational capacity, single-state semantic stability, context-sensitive intervention, avoidance of explicit context labels, coherent world-formation, and intersubjective transformability. When these requirements cannot be realized within a single global Boolean event structure, the mismatch appears, under fixed-spacetime projection, as noncommutativity, interference, and quantum-like probability. Building on prior single-state approaches to contextuality, we reinterpret classical contextual bookkeeping cost as the fixed-spacetime shadow of contextual spacetime formation. Auxiliary memory or context labels in a classical representation correspond, in this account, to holonomy-like mismatch among locally Boolean logic-worlds. The interference term is the cross term generated when locally classical realization contributions are nontrivially glued and projected back into a fixed classical spacetime form. The result is a transcendental-operational realist account: objecthood, eventhood, probability, and spacetime are treated as forms of realization under requirements, while objectivity is defined by invariants preserved across observer- and history-dependent spacetime formations.

ARC-AGI-2 is a benchmark of human-intuitive visual puzzles that measures a machine's ability to generalize from limited examples, interpret symbolic meaning, and flexibly apply rules in varying contexts. In this paper, we discuss our approach to solving the ARC-AGI-2 puzzles with TinyLM, with additional fine-tuning at test time, including Test-Time-Training (TTT) and Products of Experts (POE). Our model achieves 96.1% accuracy on the training set and 21.7% accuracy on the evaluation set.

Recent progress in generative models has significantly advanced image editing capabilities, yet precise and intuitive user control remains difficult. Specifically, users often struggle to communicate both exact spatial layouts and specific semantic details simultaneously. While natural language instructions effectively convey high-level semantics like texture and color, they lack spatial specificity. Conversely, freehand scribbles provide rough spatial boundaries but cannot express detailed visual attributes. Consequently, achieving precise control requires combining both modalities. However, existing models struggle to jointly interpret abstract scribbles alongside text due to a lack of specialized training data. In this work, we introduce ScribbleEdit, a large-scale synthetic dataset designed to bridge this gap by combining natural language instructions with freehand scribble inputs for more accurate, controllable edits. We construct this dataset through a synthetic pipeline that automatically generates source-target image pairs via inpainting, which are then paired with human-drawn scribbles and VLM-generated text instructions. Using ScribbleEdit, we evaluate and finetune both diffusion-based and autoregressive unified multimodal image editing models. Our experiments reveal that while off-the-shelf models struggle with abstract scribble inputs, finetuning on our synthetic dataset significantly improves their ability to generate spatially aligned and semantically consistent edits.

Spectral graph sparsification is a classical tool for reducing graph complexity while preserving Laplacian quadratic forms. In graph neural networks (GNNs), sparsification is often used to accelerate computation while maintaining predictive performance. In this work, we study a complementary representation-level question: does sparsification preserve the geometry of learned embeddings? For polynomial-filter GNNs, we prove that any $ε$-spectral sparsifier induces $O(ε)$ perturbations in polynomial graph filters, multilayer hidden representations, and their Gram matrices. These guarantees imply stability of squared pairwise distances, class means, and covariance structure in embedding space. We further establish finite-time training stability: under smoothness and boundedness assumptions, gradient descent on dense and sparsified graphs produces weight trajectories whose separation grows at most proportionally to the sparsification distortion. Empirically, effective-resistance sparsification validates the predicted perturbation chain on synthetic graphs and preserves hidden representation geometry on real datasets. In our experiments, the gram matrix and training dynamics show low divergence even under substantial sparsification, consistent with the predicted stability under spectral sparsification. Hidden Gram preservation strongly predicts neighborhood preservation and class-centroid stability across FashionMNIST, Cora, and Paul15. Together, these results show that spectral sparsification preserves not only graph operators, but also the representation geometry that supports downstream use of GNN embeddings for interpretability.

In this work, we introduce DUET (Dual-model Efficient Two-stage inference), a collaborative inference framework in which a capable model and a lightweight model work together to solve a task. Relying on a single large model to perform end-to-end reasoning and prediction often incurs substantial inference cost. In contrast, DUET decomposes inference into two stages: the capable model produces a reasoning signal, and the lightweight model interprets this signal to generate the final answer, allowing reasoning-intensive computation to be handled by the capable model while non-reasoning-intensive components are delegated to the lightweight model without sacrificing task performance. To achieve this objective, we propose a length-penalized joint training objective that encourages the capable model to transmit only the information that is sufficient for the lightweight model to solve the task. As a result, DUET maintains strong reasoning performance with substantially lower inference cost than end-to-end inference using a large model alone, saving up to 60% of the large model's output tokens on challenging reasoning benchmarks, including AIME and GPQA.

Symbolic regression discovers explicit, interpretable equations without assuming a functional form in advance. A Bayesian approach strengthens this through probability distributions over candidate expressions, thus quantifying uncertainty in the presence of noisy and limited data. Deep Symbolic Regression (DSR) uses a neural network to generate symbolic expressions, but it is designed to identify a single best-fitting expression rather than infer a posterior distribution over models. We introduce Deep Variational Inference Symbolic Regression (DVISR), a variational Bayesian extension of DSR. DVISR replaces the original reward with the integrand of the evidence lower bound. It also extends the network architecture to output distributions over constants within expressions, enabling posterior inference over both expression trees and their associated constants. We show that DVISR can recover the true posterior in simple settings, both with and without constant tokens, and we examine how its performance changes as the size of the expression space increases. These results position DVISR as a step toward scalable Bayesian symbolic regression with uncertainty over full symbolic models.

R2 score is the standard metric for evaluating regression tasks, offering a normalized magnitude-agnostic measure of accuracy that captures variance. However, R2 has three key limitations: it is limited to at most two dimensional inputs, it reduces the score to a single scalar that hides rich patterns of prediction accuracy, and it is sensitive to low-variance noise channels which can yield large, uninterpretable negative values. We introduce the Dimensional R2 score (Dim-R2), a simple extension of R2 that accepts data of arbitrary dimensionality, provides a multidimensional view of accuracy, and reduces sensitivity to noise. We demonstrate its advantages on both synthetic sinusoidal data and three multidimensional regression datasets. Dim-R2 offers an interpretable and flexible metric that highlights patterns in regression accuracy, guiding regression modeling.

The co-optimization of geometry and physical parameters remains challenging in transient multiphysics systems involving moving boundaries, nonlinear material response, phase transitions, and competing objectives. Existing methods often optimize geometry and physical variables separately, rely on simplified steady-state physics, or require offline data generation and reduced design spaces. Here, we present an end-to-end differentiable co-optimization framework that couples an implicit neural representation of geometry with a JAX-compiled Eulerian multiphysics solver. Geometry is represented as a signed distance field using Fourier-feature-encoded spatial coordinates, while boundary conditions, initial conditions, process controls, and material parameters are optimized within the same differentiable loop. Continuous relaxations represent non-smooth physical transitions while preserving compatibility with reverse-mode automatic differentiation and backpropagation through time. We demonstrate the framework using a transient hamburger-cooking benchmark, selected as an interpretable multiphysics problem rather than a culinary optimization exercise. The benchmark combines conductive and convective heat transfer, latent energy effects, moisture and fat transport, shrinkage-induced geometry evolution, evolving contact boundary conditions, flipping-induced boundary-condition changes, and competing quality objectives. Results show that geometry-only optimization modifies shape to relieve thermal bottlenecks, while joint co-optimization distributes the design response across geometry, material state, process variables, and boundary conditions through gradients propagated over the full transient rollout.

Multimodal Emotion Recognition (MER) is critical for interpreting real-world interactions. While Multimodal Large Language Models (MLLM) have shown promise in MER, their internal decision-making mechanisms under modality conflict and missingness remain largely underexplored. In this paper, to systematically investigate these behaviors, we introduce EmoMM, a comprehensive benchmark featuring modality-aligned, conflict, and missing subsets. Through extensive evaluation, we uncover a Video Contribution Collapse (VCC) phenomenon, where MLLM marginalize video evidence due to high token redundancy and modality preferences. To address this, we propose Conflict-aware Head-level Attention Steering (CHASE), a lightweight mechanism that detects modality conflicts and performs inference-time attention steering, effectively mitigating decision bias without retraining the backbone. Experimental results demonstrate that CHASE consistently improves performance across various settings, significantly enhancing the reliability of MLLM in complex affective scenarios.

Statistical change point (CP) detection methods typically rely on likelihood-based inference and ignore contextual information about plausible CP locations beyond the observed sequence. Although informative priors provide a natural way to incorporate such information, general and computationally efficient methods for doing so are lacking, especially for multiple CP detection. To address this gap, we propose a prior-informed CP detection algorithm (Pi-Change) that incorporates prior information on CP locations through a time-varying penalty term. We prove that the proposed penalty can be embedded in the Pruned Exact Linear Time framework while preserving the dynamic programming recursion and pruning rule required for efficient multiple CP detection. Across simulation studies and three time-series applications, Pi-Change discourages spurious CPs unsupported by prior information, remains robust to prior misspecification, and improves detection accuracy. More broadly, Pi-Change extends multiple CP detection beyond purely data-driven fitting by incorporating partial prior knowledge in a computationally efficient and interpretable way. It is particularly useful when CPs arise from heterogeneous mechanisms or are associated with known external events, helping quantify the delay between an event and the resulting structural change.

Large language models are increasingly deployed as autonomous coding agents and have achieved remarkably strong performance on software engineering benchmarks. However, it is unclear whether such success transfers to computational scientific workflows, where tasks require not only strong coding ability, but also the ability to navigate complex, domain-specific procedures and to interpret results in the context of scientific claims. To address this question, we present AutoMat, a benchmark for evaluating LLM-based agents' ability to reproduce claims from computational materials science. AutoMat poses three interrelated challenges: recovering underspecified computational procedures, navigating specialized toolchains, and determining whether the resulting evidence supports a claim. By working closely with subject matter experts, we curate a set of claims from real materials science papers to test whether coding agents can recover and execute the end-to-end workflow needed to support (or undermine) such claims. We then evaluate multiple representative coding agent settings across several foundation models. Our results show that current LLM-based agents obtain low overall success rates on AutoMat, with the best-performing setting achieving a success rate of only 53%. Error analysis further reveals that agents perform worst when workflows must be reconstructed from paper text alone and that they fail primarily due to incomplete procedures, methodological deviations, and execution fragility. Taken together, these findings position AutoMat as both a benchmark for computational scientific reproducibility and a tool for diagnosing the current limitations of agentic systems in AI-for-science settings.

With the development of deep learning, medical image processing has been widely used to assist clinical research. This paper focuses on the denoising problem of low-dose computed tomography using deep learning. Although low-dose computed tomography reduces radiation exposure to patients, it also introduces more noise, which may interfere with visual interpretation by physicians and affect diagnostic results. To address this problem, inspired by Cycle-GAN for unsupervised learning, this paper proposes an end-to-end unsupervised low-dose computed tomography denoising framework. The proposed framework combines a U-Net structure for multi-scale feature extraction, an attention mechanism for feature fusion, and a residual network for feature transformation. It also introduces perceptual loss to improve the network for the characteristics of medical images. In addition, we construct a real low-dose computed tomography dataset and design a large number of comparative experiments to validate the proposed method, using both image-based evaluation metrics and medical evaluation criteria. Compared with classical methods, the main advantage of this paper is that it addresses the limitation that real clinical data cannot be directly used for supervised learning, while still achieving excellent performance. The experimental results are also professionally evaluated by imaging physicians and meet clinical needs.

In biomechanical systems, observable performance is often used as a proxy for underlying organization, although similar outputs may arise from different adaptive configurations. This study considers the vertical dimension of occlusion (VDO) as a constraint applied to an adaptive neuromechanical system. A single-case design in a patient with Parkinson's disease enabled repeated intra-individual gait observations under six occlusal probes. Three complementary analytical levels were examined: (i) an aggregated scalar score of observable performance, (ii) a conceptual dynamical systems framework, and (iii) an exploratory UMAP representation of 55 standardized biomechanical variables from 270 M1 observations. The revised Level 1 analysis showed that the relative ranking of OC2.5 and OC3 depended on score construction, while their scalar distributions remained close. The Level 3 embedding showed substantial overlap among all six probes and did not identify independently separated condition-specific clusters. OC2.5 and OC3 displayed limited centroid displacement but broad observation-level overlap. The principal result is therefore representational non-identifiability: neither the aggregated score nor the selected low-dimensional embedding uniquely identifies an occlusal-condition-specific system state. VDO is interpreted as a constraint parameter rather than a causal determinant. The findings are exploratory, model dependent, and non causal. They do not establish distinct physiological states, an optimal VDO, clinical thresholds, or diagnostic, predictive, mechanistic, or prescriptive validity.

This study proposes a novel approach to extract topological properties, specifically the Euler characteristic, from input images using neural networks without relying on large pre-existing datasets but with a single geometric image. Inspired by solid-state physics, where topological properties of magnetic structures are derived from spin field analysis, our model generates a unit vector field from an image, interpreted as a spin configuration. The Euler characteristic is then predicted by computing the skyrmion number of this generated spin configuration. Remarkably, the network learns to construct chiral magnetic textures without access to ground-truth chiral spin configurations, relying instead on only a single, simple geometric image and the straightforward skyrmion number computation. Furthermore, spin configurations generated by independently trained networks can be non-unique due to inherent degrees of freedom. To constrain these degrees of freedom and further refine the spin configuration, we incorporate a magnetic Hamiltonian, comprising exchange interaction, Dzyaloshinskii-Moriya (DM) interaction, and anisotropy, as an additional, physics-informed loss function. We validate the model's efficacy on complex geometrical shapes and demonstrate its applicability to practical tasks.

Large language model (LLM) agents require long-term user memory for consistent personalization, but limited context windows hinder tracking evolving preferences over long interactions. Existing memory systems mainly rely on static, hand-crafted update rules; although reinforcement learning (RL)-based agents learn memory updates, sparse outcome rewards provide weak supervision, resulting in unstable long-horizon optimization. Drawing on memory schema theory and the functional division between prefrontal regions and hippocampus regions, we introduce MemCoE, a cognition-inspired two-stage optimization framework that learns how memory should be organized and what information to update. In the first stage, we propose Memory Guideline Induction to optimize a global guideline via contrastive feedback interpreted as textual gradients; in the second stage, Guideline-Aligned Memory Policy Optimization uses the induced guideline to define structured process rewards and performs multi-turn RL to learn a guideline-following memory evolution policy. We evaluate on three personalization memory benchmarks, covering explicit/implicit preference and different sizes and noise, and observe consistent improvements over strong baselines with favorable robustness, transferability, and efficiency.

We study adaptive querying for learning user-dependent quantities of interest, such as responses to held-out items and psychometric indicators, within tight query budgets. Classical Bayesian design and computerized adaptive testing typically rely on restrictive parametric assumptions or expensive posterior approximations, limiting their use in heterogeneous, high-dimensional, and cold-start settings. We introduce a persona-induced latent variable model that represents a user's state through membership in a finite dictionary of AI personas, each offering response distributions produced by a large language model. This yields expressive priors with closed-form posterior updates and efficient finite-mixture predictions, enabling scalable Bayesian design for sequential item selection. Experiments on synthetic data and WorldValuesBench demonstrate that persona-based posteriors deliver accurate probabilistic predictions and an interpretable adaptive elicitation pipeline.

Prevailing machine-learned interatomic potential (MLIP) uncertainty-quantification methods rely on ensembles of independently trained backbones. These methods scale unfavorably with foundation-scale MLIPs, and their member-disagreement signals correlate weakly with per-molecule prediction error. Here we probe the frozen per-atom representations of a pretrained MLIP with a compact discriminative classifier, recasting MLIP uncertainty quantification as selective classification rather than error regression. The resulting method, PROBE (Post-hoc Reliability frOm Backbone Embeddings), produces a per-prediction reliability probability that monotonically tracks actual error without modification to the underlying model. Across large held-out evaluation sets and two structurally distinct MLIP architectures, PROBE outperforms ensemble disagreement as a binary reliability signal, which strengthens with the expressiveness of the backbone representation, implying a favorable scaling trajectory toward foundation-scale MLIPs. Multi-head self-attention additionally yields per-atom importance maps, providing chemically interpretable diagnostics at no additional computational cost. PROBE is post-hoc and architecture-agnostic, and is directly deployable on any MLIP that exposes per-atom representations.

Dimensionality reduction (DR) techniques are often characterized by whether they preserve global, high-level structures in the data or local, neighborhood structures. This distinction matters in visualization: global methods can obscure clusters while local methods can over-emphasize them. Yet, even when clusters appear distinct, their relative arrangement in the projection may be arbitrary or misleading, a common issue in techniques such as t-SNE and UMAP. Existing cluster quality metrics either only measure cluster separability or assume spherical, globular clusters in the original space. We introduce the Class Angular Distortion Index (CADI), a metric that uses internal angles among point triples to determine the faithfulness of cluster organization in a projection. We show cases on both real and synthetic data where existing cluster metrics fail, but CADI provides an interpretable result. Since it relies on computing angles, CADI is also differentiable, enabling optimization. We demonstrate this with a CADI-based DR technique.

The visual modality of vision-language models (VLMs) is an underexplored attack surface for bypassing safety alignment. We introduce four jailbreak attacks exploiting the vision component: (1) encoding harmful instructions as visual symbol sequences with a decoding legend, (2) replacing harmful objects with benign substitutes (e.g., bomb -> banana) then prompting for harmful actions using the substitute term, (3) replacing harmful text in images (e.g., on book covers) with benign words while visual context preserves the original meaning, and (4) visual analogy puzzles whose solution requires inferring a prohibited concept. Evaluating across six frontier VLMs, our visual attacks bypass safety alignment and expose a cross-modality alignment gap: text-based safety training does not automatically generalize to harmful intent conveyed visually. For example, our visual cipher achieves 40.9% attack success on Claude-Haiku-4.5 versus 10.7% for an equivalent textual cipher. To further our insight into the attack mechanism, we present preliminary interpretability and mitigation results. These findings highlight that robust VLM alignment requires treating vision as a first-class target for safety post-training.

Federated learning (FL) offers a promising framework for collaborative digital pathology by enabling model training across institutions. However, real-world deployments face heterogeneity arising from diverse multiple instance learning (MIL) architectures and heterogeneous feature extractors across institutions. We propose FedHD, a novel FL framework that performs local Gaussian-mixture feature alignment tailored for WSI analysis. Instead of exchanging model parameters, each client independently distills semantically rich synthetic feature representations aligned with the distribution of real WSIs. To preserve diagnostic diversity, FedHD adopts a one-to-one distillation strategy, generating a synthetic counterpart for each real slide to avoid over-compression. During federation, a curriculum-based integration strategy progressively incorporates cross-site synthetic features into local training once performance plateaus. Furthermore, an optional interpretation module reconstructs pseudo-patches from synthetic embeddings, enhancing transparency. FedHD is architecture-agnostic, privacy-preserving, and supports personalized yet collaborative training across diverse institutions. Experiments on TCGA-IDH, CAMELYON16, and CAMELYON17 show that FedHD consistently outperforms state-of-the-art federated and distillation baselines.

Clinical reasoning demands multi-step interactions -- gathering patient history, ordering tests, interpreting results, and making safe treatment decisions -- yet a unified training environment provides the breadth of clinical domains and specialized tools to train generalizable medical AI agents through reinforcement learning remains elusive. We present a comprehensive empirical study of multi-turn agentic RL for medical AI, built on \gym{}, a gymnasium-compatible environment spanning 10 clinical domains with 3.6K+ tasks, 135 domain-specific tools, and a knowledge base of 828K medical passages. Our analysis reveals that agentic multi-turn structure degrades into verbose single-turn monologues, characterized by monotonic length explosion and a simultaneous erosion of tool-use frequency. We characterize how this collapse, alongside distillation instability, stems from the misalignment of sparse terminal rewards with sequential clinical trajectories. We find that vanilla GRPO achieves strong final accuracy on some benchmarks but suffers from training instability, evidenced by significant oscillations in response length and prolonged convergence periods. To improve training efficiency and stability, we propose Turn-level Truncated On-Policy Distillation (TT-OPD), a self-distillation framework where a gradient-free EMA teacher leverages outcome-privileged information to provide dense, outcome-aware KL regularization at every conversation turn. TT-OPD achieves the best performance on 10 of 18 benchmarks with an average +3.9~pp improvement over the non-RL baseline with faster early convergence, controlled response length, and sustained multi-turn tool use.

Text-to-image diffusion models generate images by gradually converting white Gaussian noise into a natural image. White Gaussian noise is well suited for producing diverse outputs from a single text prompt due to its absence of structure. However, this very property limits control over, and predictability of, specific visual attributes, as the noise is not human-interpretable. In this work, we investigate the characteristics of the input noise in diffusion models. We show that, although all frequencies in white Gaussian noise have comparable statistical energy, low-frequency components primarily determine the images global structure and color composition, while high-frequency components control finer details. Building on this observation, we demonstrate that simple manipulations of the low-frequency noise using low-frequency image priors can effectively condition the generation process to reconstruct these low-frequency visual cues. This allows us to define a simple, training-free method with minimal overhead that steers overall image structure and color, while letting high-frequency components freely emerge as fine details, enabling variability across generated outputs.

Inferring cellular trajectories from destructive snapshots is complicated by the challenges of stochasticity and non-conservative mass dynamics such as cell proliferation and apoptosis. Existing unbalanced Optimal Transport (OT) methods treat mass as a continuous fluid, performing inference at the population level. However, this macroscopic view often fails to capture the discrete, jump-like nature of birth-death events at single-cell resolution, which is essential for understanding lineage branching and fate decisions. We present Unbalanced Schrödinger Bridge (USB), a simulation-free framework for learning underlying dynamics that effectively integrates both stochastic and unbalanced effects which also models the discrete, jump-like birth-death dynamics at single-cell resolution. Theoretically, USB provides a tractable solution to the Branching Schrödinger Bridge (BSB) problem, offering a rigorous microscopic interpretation where individual cells undergo both Brownian motion and discrete birth-death jumps. Technically, the method implements an efficient solver by introducing a simulation-free training objective that effectively scales to high-dimensional omics data. Empirically, we demonstrate on both simulated and real-world datasets that USB not only achieves trajectory reconstruction performance better than or comparable to deterministic baselines but also uniquely enables realistic discrete simulation of birth-death dynamics at single-cell resolution.

Blood vessel segmentation and -tracing are essential tasks in many medical imaging applications. Although numerous methods exist, the prevailing segment-then-fix paradigm is fundamentally limited regarding its suitability for modeling the task of complete and topologically accurate vascular network reconstruction. Here, we propose an approach to extract topologically more accurate vascular graphs from 3D image data, building upon highly successful ideas from the related biomedical tasks of cell segmentation and -tracking. Our approach first predicts voxel-wise vessel direction vectors joint with standard vessel segmentation masks. Second, to extract the vascular graph from these predictions, we introduce a direction-vector-guided extension of the TEASAR algorithm. Our approach achieves state-of-the-art performance on three benchmark datasets, spanning both synthetic and real imagery. We further demonstrate the applicability of our approach to challenging 3D micro-CT scans of rat heart vasculature. Finally, we propose meaningful and interpretable measures of topological error, namely false splits and false merges for graphs. Overall, our approach substantially improves the topological accuracy of reconstructed vascular graphs, being able to separate closely apposed vessel segments and handle multiple vascular trees within a single volume.