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Although text-to-image diffusion models generally exhibit strong prompt-following ability, we identify a persistent and previously underexplored failure pattern in which a small subset of prompts differing only in the object consistently fails to realize the same target concept under identical generation settings. We term this phenomenon object-dependent concept brittleness. Such cases suggest systematic internal blind spots rather than random sampling noise. In this paper, we present an interpretability-oriented framework to audit and minimally correct these failures. Our key idea is to analyze denoising trajectories in a step-wise sparse autoencoder (SAE) space, where abstract style and attribute concepts become more separable than in the raw denoising representation. This sparse space enables us to compare successful and failed generations, identify concept dimensions whose evidence is missing, weakened, or temporally delayed, and construct class-level concept prototypes from reliable class-consistent samples. Based on this audit process, we introduce a lightweight inference-time correction strategy that interpolates denoising features toward the corresponding prototype in SAE space. Rather than serving as a task-specific retraining method, this intervention acts as a validation of the diagnosed concept deficiency. We evaluate the proposed framework on style and attribute failure cases across multiple diffusion backbones, with significant improvements in concept consistency, text fidelity, and repair success. Further analyses show that deeper denoising representations provide clearer concept structure, while early-stage intervention offers the strongest correction leverage. Code is available at https://github.com/Metecade/Object-Dependent-Concept-Brittleness.

Low-latency simultaneous speech-to-speech translation must keep pace with ongoing speech while preserving key information. To meet these demands, systems use segmentation, reformulation and condensation to reorganize and rephrase information. However, metrics developed for text translation, including BLEU and COMET, may not consistently distinguish faithful adaptations from semantic errors. We propose EviSI, a large language model evaluation agent combining Multidimensional Quality Metrics (MQM) with criteria developed with professional interpreters. Shared source evidence guides assessment across four dimensions: Anchor, Event, Logic and Fluency. Verified errors are deduplicated before deterministic scoring. On human-rated English to Chinese and Chinese to English data, EviSI recovers the aggregate English to Chinese human system ranking. Mean within-dataset Kendall correlations for system rankings reach 0.707 and 0.467, respectively, exceeding evaluated BLEU and COMET baselines. A multilingual extension to five directions without human ratings retains the dimensions and scoring rule, showing positive system ranking correlations with COMET throughout.

Vision Language Models have achieved strong performance on multimodal benchmarks, yet their ability to reason about culturally grounded and metaphor-rich content remains insufficiently studied. Internet memes present a challenging setting where meaning emerges from implicit interactions between image, overlaid text, sarcasm, and shared socio-cultural knowledge rather than literal visual recognition. This challenge is amplified in low-resource languages such as Bangla, where code-mixing, stylized scripts, and culturally specific symbolism introduce substantial distribution shift. In this work, we introduce BanglaMemeX, a culturally grounded multimodal benchmark comprising 3,000 Bangla memes annotated with multi-dimensional labels (humor, sarcasm, offensiveness, motivational intent, and overall sentiment) and human-written explanations that explicitly describe textual and visual metaphors. We systematically evaluate modern VLMs on both classification and explanation generation, revealing that current models struggle to interpret implicit cultural cues despite reasonable surface-level accuracy. Our results highlight the need for culturally-aware multimodal systems capable of grounded reasoning under linguistic and cultural distribution shift.

Large language models (LLMs) frequently generate source code containing vulnerabilities, yet little work studies the internal mechanisms that distinguish safe from vulnerable generation in them. In this work, we systematically perform a mechanistic interpretation of LLMs, aiming at both understanding how code safety-vs-vulnerability is represented or driven by components in an LM and turning the insights into actionable steering strategies to encourage safer code generation. To this end, we introduce CodeSec-Pairs, a dataset of 9,342 Python safe-and-vulnerable contrastive code pairs, sampled from Llama-3.1-8B-Instruct. Utilizing the dataset, we explore approaches to localize layers and attention heads that relate to code safety, and further experiment with different steering strategies for inference-time vulnerability reduction. In particular, we propose DuoSteer, a double-steering approach that simultaneously applies safety and code-correctness steering to attention heads. In experiments over five vulnerability types, DuoSteer leads to an average of -26.9% vulnerability rate reduction and +7.5% functional correctness improvement, which outperforms not only other steering variants but also prompting and supervised fine-tuning baselines. The advantage also replicates on Qwen-2.5-Coder-7B-Instruct with another 2,500 contrastive pairs sampled from that model.

In this work, we introduce DMDIntel which uses dynamic mode decomposition (DMD) to make the predictions made by LLMs in a classification task interpretable. It develops an input attribution pipeline, that first decomposes the hidden states of an LLM into prominent patterns, also known as modes, and then associates ranks to the input tokens based on the projection values on those modes. Rigorous experiments across three datasets and three model families consistently show that the ranked attribution of input tokens obtained using DMDIntel by far outperforms state-of-the-art techniques such as principal component analysis, integrated gradients and SHAP.

Although existing instruction data selection methods have introduced various metrics, the inherent complexity of real-world datasets makes it impractical for any single metric to generalize across all scenarios. Developers are thus often forced to manually inspect data and craft heuristic rules for each new application---a tedious and error-prone process. In this paper, we propose a paradigm shift from manual configuration to automated orchestration via the Instruction Data Selection Agent (DataMaster), which interprets user intent and autonomously composes optimal selection strategies. By allowing users to specify data needs through natural language descriptions, DataMaster simplifies data curation and removes the burden of manual strategy design. Extensive experiments across the math, medical, and code domains show that DataMaster outperforms static baselines in most settings and surpasses full-pool training in a substantial number of cases. The implementation of DataMaster and the scripts needed to reproduce the reported pipeline are publicly available at https://github.com/nju-websoft/DataMaster.

Lens methods interpret large language models (LLMs) by mapping intermediate activations to the output vocabulary, revealing how next-token predictions develop through the network. Trained lenses remain expensive: affine-translator parameters grow quadratically with model width, while exact, full-vocabulary Kullback--Leibler (KL) training dominates memory. Consequently, prior trained lenses have been applied to models of at most 20B parameters and remain tied to particular component types. We present OmniLens, which applies a single lens family to any model-width activation, whether residual stream, attention, or MLP, and combines two independent scaling techniques. First, low-rank translators make per-lens parameter growth linear in model width and reduce trainable parameters by up to 98.4%. Second, Subset-KL materializes only selected vocabulary logits: its Top-k mode cuts peak training memory by up to 70%, while its importance-sampled variant retains unbiased stochastic gradients for the full KL. These savings enable a dense ensemble of 482 lenses for LLaMA-3.3-70B, providing 6x the coverage of a residual-stream design at the same depth. Model-wide coverage then reveals what single-component lenses cannot: the components where a behavior is most visible need not be those where intervention is most effective, and the most effective interventions lie outside the attention heads examined by prior lens studies. Across three case studies (prompt-injection detection, multi-hop memory injection, and toxicity localization), OmniLens reproduces key published results at substantially lower cost.

Accurate chest X-ray interpretation is inherently hierarchical. Clinical decisions depend not only on what abnormality is present but where it is situated, requiring reasoning from broad anatomical systems down to specific pathological findings. Yet existing automated systems largely treat this as a flat classification problem, failing to capture inter-level dependencies or enforce coherence between coarse and fine predictions. We propose CHASE (Classification with Hierarchical Analysis and Structured Enforcement), a unified single-stage framework that mirrors radiologists' coarse-to-fine reasoning through a clinically driven three-level taxonomy of 9 anatomical regions, 17 sub-regions, and 28 pathological findings. CHASE jointly optimizes multi-level supervision, cross-level probability alignment, and a hierarchy-violation penalty within a shared Vision Transformer backbone. This ensures that fine-grained findings are anatomically supported by their coarser-level context rather than predicted in isolation. Experiments demonstrate that CHASE outperforms flat and hierarchical baselines across all levels while achieving superior probabilistic hierarchy consistency, with level-wise attention maps confirming anatomically grounded predictions. Code is available at: https://github.com/yejix-ai/CHASE.

The distance between persons reveals significant information about their perception of each other. However, such information is not easily extractable and interpretable from video input. We developed an open-sourced library, Facial Interpersonal Distance Analysis and Coding (FIDAC) that transforms facial detection results into actionable data about location and interpersonal distance. This tool merges data from multiple open-source facial detection models, strategically compensating for gaps in any individual model. In addition, we include methods for more accurate tracking, such as a pipeline for human coding of the selection of faces and a benchmarking tool to reduce depth distortion. For next steps, we plan on building upon FIDAC by evaluating its effectiveness at measuring interpersonal distance at various depths and orientations while further integrating features of proxemic analysis such as synchrony into its software.

Automated analysis of multimodal content on social networks has become a critical task for understanding public sentiment and information diffusion in the digital age. However, classifying internet memes remains computationally challenging due to the intricate interplay between visual cues and embedded, often stylized, text, particularly in low-resource languages like Bengali Language. This paper addresses the detection of political intent in Bengali memes by introducing Multimodal Cross-Attention Fusion framework. We first leverage a Vision-Language Model to extract high-fidelity OCR text from noisy meme images. Subsequently, we encode visual and textual features and synthesize them through a cross-modal multi-head attention mechanism that aligns semantic tokens with visual regions. We also investigate the integration of a domain-specific political lexicon as a knowledge prior. Experimental evaluation on the PoliMemeDecode1 dataset shows that our attention-based fusion significantly outperforms unimodal baselines and standard concatenation methods, achieving a state-of-the-art Macro-F1 of approximately 0.94. Interpretability analyzes further confirm that the model effectively learns to ground textual semantics in visual evidence.

Optical scattering has conventionally been regarded as an impediment in imaging research due to the degradation of image quality during reconstruction. Nevertheless, this study explores two cases in which optical scattering may serve a beneficial role in image reconstruction tasks. We compared the No Scattering MNIST dataset with three Scattering MNIST datasets, each generated under distinct scattering conditions. To assess the information content of the resulting speckle patterns, we employed a Variational Autoencoder (VAE) approach which achieves accuracy comparable to state-of-the-art deep learning approaches, but has an interpretable latent space. We find that scattering can enhance data robustness against spatial pixel loss by effectively distributing information. We also demonstrate that scattering can enable distinctions of focal depth information. We anticipate that these findings will contribute to more efficient imaging techniques, particularly in the presence of obstacles and three-dimensional signals.

Generative AI is reshaping programming education, yet educators often infer students' AI-supported learning from classroom observations alone. This experience report presents a trio-ethnography involving two computing educators with different teaching philosophies and one undergraduate computer science student to examine how these interpretations evolve through dialogue. Across three conversations, the educators reflected on students' AI use, discussed changes to programming pedagogy, and revisited their assumptions after engaging with the student's lived experiences. Rather than simply confirming or contradicting the educators' perspectives, the student's narratives revealed learning processes that were largely invisible in the classroom, prompting both educators to reconsider assumptions about AI use, assessment, transparency, and programming instruction. We argue that trio-ethnography offers a valuable reflective approach for helping computing educators move beyond observable student behaviors toward a richer understanding of AI-supported learning and for informing instructional adaptation in the era of generative AI.

Discourse relations provide document structure, critical to language understanding and enabling language model performance and ethicality. In this work, we investigate how instruction-tuned Transformer models (LLaMA and Mistral) encode discourse relations in English, with a particular focus on the contrasting relations of causation and antithesis. Framing the task as a next-token prediction task and applying a suite of interpretability techniques to test model internals, our findings show that certain early layers make predictive decisions at mid-sequence tokens, while some mid-level layers finalize their decisions closer to the last token. Most of the remaining layers primarily propagate earlier decisions rather than actively influencing them. Additionally, we observe that some layers exhibit a preference for one answer over alternatives, suggesting asymmetric representation of discourse-based reasoning.\footnote{Our code is available at https://github.com/abhidipbhattacharyya/causation_vs_antithesis}

End-to-end autonomous driving models are now able to navigate complex road scenarios, mapping raw sensor observations directly to observed paths for open-loop evaluation and often effective driving in closed-loop evaluation. Yet the internal logic of these safety-critical systems remains largely opaque, due to the complexity of traffic scenes. We propose a counterfactual ablation framework called Counterfactual Vision Action Analysis (CVAA) that systematically removes individual detected objects from front-camera images using photorealistic generative inpainting to prepare counterfactual sets to evaluate the difference in the model's response. This isolates the causal effect of each object's presence on the model's planning behaviour. Applied to the Alpamayo 1 trajectory predictor across 210 nuScenes driving scenes, we create a dataset Counter -nuScenes, using which we see that vehicles and pedestrians within the model's 'path' dominate causal influence as expected, while traffic lights, as expected, exert disproportionate effect relative to their image footprint. However, we also find cases where the model responds strongly to objects a human driver would consider irrelevant. This brings forth a deeper question: does the model itself view the scene as a sum of individual objects influencing the outcome, or does it encode an entirely different set of internal features that do not correspond to human-legible scene elements? To further understand this, we compare intermediate representations of original and inpainted image pairs using mechanistic interpretability techniques and examine the effect of the removal through the various model layers. Together, these two stages offer a path from behavioral auditing to representational understanding, creating explainable driving systems and solidifying human-AI trust.

Existing hypotheses represent a concept in an LLM as a single point, a linear direction, or a Gaussian cluster, yet it remains unclear how and why such structures emerge. Here, we show that concept geometry can be precisely characterized via Laguerre Geometry, in which a concept is defined as a region--a Laguerre-Voronoi cell or a union of cells--allowing us to strictly define, measure, and separate concepts. Building on this formulation, we show that finer-grained concept structures, such as inclusion and hierarchy, are naturally revealed by the Laguerre weights. We then push this geometry inside the transformer. Decomposing each layer into piecewise-linear operators, we show that a token's hidden trajectory is governed by two coupled mechanisms: a static tree of self-contained piecewise-linear flow, and a dynamic transport that hops the trajectory across trees when cross-token attention fires. This decomposition yields Geometric Lens, a training-free, hyperparameter-free method for reading out the exact concept a hidden vector encodes at any layer. We also develop Laguerre Autoencoder, a 2D visualizer that renders both the decision geometry and a model's full reasoning trajectory in one view. Finally, we move beyond explanatory geometry toward actionable interpretability, showing that Geometric Lens recovers the correct factual token when a model is prompted with in-context interference. The code is available on GitHub.

Artificial intelligence (AI) is transforming electron microscopy by enabling quantitative analysis of increasingly large and complex datasets for nanoparticle characterization. Recent advances in machine learning (ML) and deep learning (DL) have expanded microscopy from a descriptive imaging technique into a data-driven platform for structural interpretation, dynamic analysis, and scientific inference. This review examines AI methodologies for nanoparticle electron microscopy, focusing on transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), scanning transmission electron microscopy (STEM), and in situ TEM. The discussion is organized around the principal challenges in nanoparticle characterization, including particle detection, segmentation, morphology quantification, atomic-resolution restoration, defect identification, two-dimensional-to-three-dimensional structural inference, and analysis of dynamic processes in situ. We review computational approaches from conventional ML and convolutional neural networks to transformer architectures, self-supervised learning, foundation models, multimodal AI, and physics-informed learning. We further discuss integrating microscopy data with simulations, metadata, and autonomous experimentation to relate nanoparticle structure, dynamics, synthesis conditions, and functional properties. The advantages, limitations, benchmarking, and data requirements of current methodologies are critically assessed. Finally, emerging opportunities for foundation models, AI-guided microscopy, closed-loop experimentation, and autonomous materials discovery are discussed. By integrating advances across computer vision, materials informatics, and electron microscopy, this review highlights the role of AI in next-generation nanoparticle characterization and accelerated materials discovery.

We study how unsupervised autoencoders trained on microscopic spin configurations from the Ising model learn macroscopic, theory-relevant variables underlying the data-generating process. Without embedding domain knowledge, we mimic a typical discovery setting: We quantify learning across multiple spatial (coarse-graining) scales and reveal two distinct dynamical regimes controlled by main hyperparameters (model depth, width, and learning rate) -- a magnetization-dominated regime and an energy-dominated regime characterized by trade-offs in their representation quality. The first regime is a transitory state exhibiting dynamical scaling and fluctuations that follow an ordering-to-scale; the second gradually shifts resolution towards smaller scales relevant for the energy representation. Deep models trained at moderate and fast rates become arrested before reaching these regimes. With a novel analysis of recursive-dynamic trajectories, we demonstrate that prediction errors induce flow fields that produce a common trajectory topology across all representation spaces. A dynamical viewpoint of learning is established in which intrinsic properties expose the effects of forced changes in representation during training. We utilize the intuition that learning operates as a process driven far from equilibrium by fluctuations from the training data and optimizer to provide an interpretive basis grounded in both the physical world and the machine models that represent it.

Fine-tuning on harmless data can partially undo behaviors acquired earlier in training. Safety can erode under benign post-alignment updates, unlearned capabilities can re-emerge, latent traits can transfer through apparently unrelated supervision, and related post-alignment fragility appears in other generative settings. We argue these phenomena are usefully viewed through a common training-history lens. Our hypothesis is geometric: large early training phases create dominant behavioral manifolds, while later alignment or specialization phases are shallower displacements from them. Subsequent fine-tuning can therefore inherit a persistent reversion component pointing back toward a witness of the dominant manifold. We call this the gravitational interpretation of fine-tuning reversion. Across our main settings, representational drift rapidly acquires a component along a history-defined reversion direction (v_rev). In our main track, alignment with v_rev rises from cos = 0.429 +/- 0.052 after the first update to 0.647 +/- 0.021 by step 20. Across 24 run-step pairs, every observed alignment exceeds the p99 of an isotropic activation-space null. We demonstrate that selectively blocking motion along v_rev changes the final alignment at T=100 from 0.648 +/- 0.009 to -0.211 +/- 0.021 and reduces harmfulness from 19.0% +/- 4.0% to 8.5% +/- 1.5% with little task cost. These results support v_rev as a causally relevant mediator of early post-alignment reversion in our setup. Importantly, we do not claim that v_rev is the unique safety direction, nor that the dominant manifold is directly observed; rather, we identify a robust, history-defined direction that explains and partially controls early reversion dynamics.

Low-light human action recognition remains a challenging problem due to poor illumination, amplified noise, motion ambiguity, and diverse real-world scenes. Existing low-light datasets often lack sufficient action diversity, capture realism, or balanced class distribution, limiting the development of robust models. To address this, we introduce LUMINA-26: Low-Light Understanding for Modeling and Interpreting Night-time Actions, comprising 6,784 clips across 26 action classes, recorded from 22 subjects across 20 indoor and outdoor locations under naturally occurring low-light conditions. We also propose Illumi-Net: An Illumination-Adaptive Mixture-of-Experts Network, which leverages video-level illumination cues to guide adaptive enhancement and transformer-based spatio-temporal feature extraction, with expert-conditioned decision fusion. Our method surpasses previous state-of-the-art performance on ELLAR (Top-1: 55.13%, Top-5: 78.87%) and establishes a strong baseline on LUMINA-26 (Top-1: 75.95%, Top-5: 93.58%), offering a practical benchmark for future low-light action recognition research.

This paper introduces an interpretation of Temporal Behavior Trees (TBTs) as Reward-Petri-Nets (RPNs) for reinforcement learning (RL). Designing reward functions for complex, long-horizon robotic tasks is notoriously difficult, especially when tasks have hierarchical structure and temporal constraints. TBTs extend conventional behavior trees (BTs) used in robotic applications by incorporating temporal properties into their leaf nodes. This allows TBTs to represents not only the behavioral task structure defined by BT operators such as Sequence, Fallback, and Parallel, but also the task's temporal constraints. In this work, the constraints are specified in the leaf nodes using Linear Temporal Logic. In order to inform RL rewards using TBTs, we provide a translation from TBT into a Petri Net (PN) and show how rewards can be automatically assigned based on the TBT's structure, resulting in a RPN. In a series of increasingly challenging environments, we demonstrate how TBT-based rewards enable learning where vanilla RL fails, improve sample efficiency, and offer flexible, intuitive control over the learning progress. We showcase the learning impact by using different reward distribution schemes and TBT structures.

Production data integration is bottlenecked by repeated, lossy handoffs between data owners, engineers, and analysts who must collaboratively discover, structure, and query enterprise data. We present Data Intelligence Agents (DIA), a system of three agents (Data Interpreter, Schema Creator, and Query Generator) that compresses this workflow by treating autonomous coding agents (ACAs) as a first-class abstraction: rather than emitting text, the agents generate, execute, validate, and repair concrete artifacts, draw on a shared memory for experience reuse, and surface each for review by domain experts. DIA is deployed in production for enterprise customers. We study the Query Generator in depth and evaluate it in fully autonomous mode across seven SQL benchmarks spanning four task categories and four dialects. It matches or surpasses the best published results on all seven, demonstrating that an architecture grounded in execution, built on ACAs and a shared memory, generalizes across the data intelligence workload with adaptation confined to natural-language instructions.

Figurative language and negation are two areas that challenge current language models, however, both are widely used throughout written and spoken language. Large language models (LLMs) are also widely used in everyday contexts where they cannot necessarily be tuned for a specific dataset. It is therefore essential to understand the ability of LLMs to correctly interpret text that includes both negation and figurative language. To investigate this, we develop a set of new annotations to an existing dataset of figurative language, and test a range of language models on the dataset. We find that the combination of negation and figurativeness can present a particular challenge, and that performance overall and across different negation types is particularly dependent on the prompt style used.

Reasoning with a Code Interpreter (CI) has emerged as an effective paradigm for enhancing the reasoning capabilities of large language models (LLMs) through executable computation and iterative verification. Despite its growing adoption, the behavioral properties underlying effective code reasoning remain largely underexplored. In this work, we investigate code reasoning from two distinct perspectives inspired by prior studies of natural language reasoning: extrinsic properties, represented by crucial tokens, and intrinsic properties, represented by code-specific cognitive behaviors. Across multiple LLMs, we find that stronger CI reasoning models consistently exhibit a higher prevalence of crucial tokens and cognitive behaviors, particularly verification, backtracking, and backward chaining. Building on these observations, we examine how these properties can be leveraged during both inference and training. At inference time, appending code-specific crucial tokens improves performance on several reasoning capabilities, including mathematical, ordering, and optimization, while yielding limited benefits elsewhere. At training time, augmenting a state-of-the-art framework with code-specific cognitive behaviors improves supervised fine-tuning and reinforcement learning performance in two of three evaluated models. Further analysis shows that these behaviors reduce overthinking in incorrect responses and improve token efficiency, while also revealing factors that limit gains in a certain model. Our findings provide the first systematic characterization of effective reasoning with CI and demonstrate both the potential and limitations of leveraging key properties to improve CI-based reasoning.

Clustering is widely used for exploratory analysis and scientific discovery, driving insights from market segmentation to biological data analysis, but its outputs can be difficult to interpret, audit, and reproduce as modern datasets become increasingly large and complex. Reliable use of clustering requires understanding which features drive the discovered structure, yet feature-level explanations for clustering remain scarce compared with methods in supervised learning. Furthermore, existing clustering feature importance scores are often tied to specific algorithms and data assumptions. To address these challenges, we propose Cluster LOCO (Leave-One-Covariate-Out), a family of model-agnostic feature importance scores for clustering. Cluster LOCO is built on feature occlusion and clustering generalizability, defined as whether cluster labels learned on one subset of the data can be accurately predicted on held-out samples. For any chosen clustering algorithm, Cluster LOCO quantifies a feature's importance by measuring how much its removal degrades generalizability. We first introduce Cluster LOCO-Split, which relies on data splitting, and then extend it to Cluster LOCO-MP, a minipatch ensemble-based version designed for large-scale data. Across synthetic simulations and an application to cell-type discovery in single-cell transcriptomics, we show that Cluster LOCO more reliably recovers informative features than existing clustering feature importance methods.

Personalized health AI systems face a fundamental cold-start problem: machine learning models for physiological interpretation require weeks of individual behavioral data before they can distinguish constitutional variation from environmentally driven deviation. We propose a solution grounded in causal inference and Bayesian prior design. An individual's genomic profile serves as an exogenous genetic anchor -- a domain-informed, personalized prior that is fixed at conception, immune to reverse causation, and available before a single behavioral observation is collected. The anchor initializes a Bayesian belief state over an individual's physiological set point G-hat = mu + sum(beta_i * g_i), where beta_i are GWAS-derived effect sizes and g_i are risk-allele counts. Each incoming physiological measurement P produces a non-constitutional deviation delta = P - G-hat that separates the signal attributable to environment and state from the constitutionally fixed baseline. As behavioral data accrue, the prior decays according to G-hat_t = w(t)*G-hat_genomic + [1-w(t)]*P-bar_t, transitioning from genome-dominated to empirical-baseline-dominated inference. The same observed HRV of 55 ms generates a suppression hypothesis for a person whose prior predicts 80 ms, and an enhancement hypothesis for a person whose prior predicts 30 ms -- a reversal impossible without a personalized anchor. We develop this architecture across six physiological domains, grading genomic priors by evidence strength, distinguishing robustly replicated anchors (FTO, FADS1/2, FKBP5) from contested candidate genes (SLC6A4, MAOA, DRD2). We address the inference boundary between association, Mendelian randomization, and individual token causation, and define four constraints for deployment: evidence-graded priors, dynamic decay, ancestry-matched effect sizes, and attribution rather than deterministic output.

The deployment of LLM-based agents in scientific analysis raises opposing concerns: that agents may reduce methodological diversity, or that they may amplify the analytic flexibility through which researchers reach motivated conclusions. We argue these worries target two empirically separable layers: a design layer of methodological choices, and a verdict layer in which a decision rule maps estimates to a substantive claim. We test both by running 20 independent executions of Claude Code and Codex on a prominent immigration and social-policy against a many-analysts human baseline. At the design layer, Codex matches human methodological diversity and Claude Code produces nearly three times as many specifications; both agents' effect estimates remain broadly aligned with the human consensus, and no agent model exactly matches any human model. A prompt-induced anti-immigration researcher prior reorganizes each agent's methodological decisions but, unlike for biased human analysts in the same data, does not shift aggregate estimates or final verdicts; nor do agents reroute along the methodological axes humans use to bias their estimates. At the verdict layer, an explicit confirmatory prompt flips Claude Code's verdicts from 10% to 90% support while leaving its coefficient distribution essentially unchanged, operating through rule omission rather than rule softening. AI agents can rival or exceed human methodological diversity at the design layer while remaining vulnerable at the verdict layer. In our setting, the locus of AI bias is not estimation but interpretation.

Suicide ideation detection models are typically evaluated using aggregate performance metrics, yet little is known about how they internally represent psychologically meaningful risk factors. In high-stakes mental health applications, understanding these internal representations is essential for safety, transparency, and responsible deployment. In this work, we move beyond accuracy and analyze how suicide detection models trained on original and topic-augmented datasets encode psychological risk factors in their internal representation space. Using visualization and geometric analysis, we examine the coherence and separability of topic-related features. Our results show that topic-aware augmentation increases the clarity and distinctness of underrepresented psychosocial risk factors such as immigration, family issues, and financial crisis. These findings suggest that augmentation not only improves model performance but also leads to more structured and interpretable internal representations.

Cancer care requires a longitudinal approach in which treatments are planned and delivered over time according to the needs of each individual patient. While prior research has thoroughly explored how clinical and demographic factors, such as comorbidities and age, inform treatment planning, far less attention has been devoted to the delivery phase of care. Yet planning and delivery are both team-based processes that depend on coordinated efforts among multiple healthcare professionals (HCPs). As such, the human factors embedded in these collaborative practices are crucial to optimizing patient outcomes. Despite this importance, the existing literature on human factors in cancer care is limited, and very few studies have investigated how collaboration within care teams evolves over the course of treatment. To fill this gap, this work examine how HCPs' collaboration, captured through electronic health record (EHR) systems, affects cancer patient outcomes, with particular emphasis on teamwork dynamics. We represent EHR-mediated HCP interactions as networks and apply machine learning methods to identify predictive signals of patient survival embedded in these collaborative structures. We further interpret model predictions by pinpointing network characteristics and dynamic patterns associated with particular outcomes. We evaluate our model through robustness analyses to ensure that the findings are stable and not driven by stochastic variation in training. Additionally, our insights align with hypotheses proposed in the medical literature, and our results provide the empirical, data-driven evidence supporting these claims. Overall, our work contributes a practical workflow for leveraging digital traces of collaboration to evaluate and strengthen longitudinal team-based healthcare, offering actionable insights to guide data-informed interventions in healthcare delivery.

We consider establishing the interpretability theory of deep learning through constructing a corresponding relationship between the renormalization group (RG) method in statistical physics and the training process of deep neural networks (DNNs). We have proved the constructed relationship using the one-dimensional Ising model as the input data. In this paper we generalize our results to the case of continuous input data, which is a necessary preparation for applying the corresponding framework to real-world data. To be representative, we consider a class of data distribution in the exponential family. We prove that when the parameters of fully connected (FC) DNNs achieve their optimal value after training, the characteristic parameters of the feature layer output of DNNs are equal to the fixed points of the characteristic parameters of input data under RG method for continuous fields. This conclusion shows that the training process of DNNs is equivalent to RG calculation on this kind of data and therefore the network can extract main features from the input data just like RG. Also, the equivalence further validates the correspondence framework we have established, providing an explanation for the outstanding performance of DNNs on real-world data.

High-fidelity ECG interpretation is increasingly reliant on massive foundation models, yet their deployment in clinical edge-care remains hindered by extreme computational demands. While knowledge distillation (KD) is a promising solution, traditional methods fail to capture the complex spatio-temporal dependencies of ECG signals when transferring knowledge across heterogeneous architectures. In this paper, we propose EVL-ECG, a framework specifically designed for cross-architecture distillation of cardiac diagnostic logic. EVL-ECG introduces three ECG-aware innovations: (1) Multi-Head Cross-Attention Alignment, which harmonizes architectural discrepancies to preserve fine-grained morphological features; (2) Optimal Transport-based Visual Feature Matching, utilizing optimal transport to maintain global structural relationships across ECG leads despite mismatched token representations; and (3) Geometric Intra-Architecture Relation Matching, which distills the latent diagnostic reasoning of the teacher model. Evaluations across ECG benchmarks demonstrate that EVL-ECG yields improvements of up to 2.4% AUC and 1.1% clinical accuracy over existing baselines. Notably, EVL-ECG establishes an efficient 2B-parameter ECG foundation model, suitable for resource-constrained clinical environments.