Autism Spectrum Disorder

Challenging behaviors including aggression, self-injury, and property destruction are observed in 68% of autistic youth and pose risks to youth and caregivers. These episodes are preceded by agitation, a rising state of distress expressed through movement, vocalization, and autonomic arousal. Its signs are subtle and individualized, and its autonomic components are invisible without instrumentation. We collected upper-body movement from inertial measurement units, physiology from a wrist-worn device, and vocalizations from lapel microphones across 30 clinician-led sessions with 15 autistic youth, paired with expert behavioral annotations. We adapt four pretrained foundation models, one per modality, project each to a shared 128-dimensional space, and fuse them into a single group model. The model detected agitation with an area under the ROC curve of 0.724 at the clinician-annotated onset (within-participant permutation p=0.0005), declining to 0.608 at 30,s before onset. Thirteen of fifteen participants were above chance. A from-scratch configuration reached only 0.58, while frozen and fine-tuned features performed comparably (0.71 and 0.72). Audio contributed most of the signal, and a watch-only configuration stayed near chance. Individualized agitation is therefore detectable, including in unannotated windows preceding the annotated onset, using foundation-model transfer with one shared model rather than one per child.

Accurate classification of brain disorders from neuroimaging data remains challenging because of substantial inter-subject heterogeneity and the complex multi-scale patterns present in functional connectivity and morphological representations. To address these challenges, we propose HyperAMS-Net, a deep learning framework for brain disorder classification using neuroimaging representations derived from resting-state functional MRI or structural MRI. HyperAMS-Net integrates adaptive multi-scale convolution, hypergraph attention, spatial-channel attention, and adaptive feature fusion. Specifically, adaptive multi-scale convolution learns data-driven weights over multiple receptive fields to capture complementary patterns at different scales. Hypergraph attention models higher-order dependencies among learned feature representations through node--hyperedge--node message passing, while spatial-channel attention enhances discriminative feature learning. Adaptive feature fusion further aggregates complementary information across parallel network branches. HyperAMS-Net is evaluated on three benchmark datasets spanning distinct brain disorders: ABIDE for autism spectrum disorder, REST-meta-MDD for major depressive disorder, and ADNI for Alzheimer's disease, using 5-fold stratified cross-validation. HyperAMS-Net achieves state-of-the-art performance across all evaluated datasets, attaining the highest accuracy and AUC among the compared methods. Ablation studies further demonstrate the contribution of each proposed component, with the largest performance degradation observed when hypergraph attention is removed.

Adults with intellectual and developmental disabilities (IDD) are increasingly transitioning from family homes towards semi-inde-pendent living. As parents hand off the role of primary caregiver, they face numerous challenges in arranging consistent and quality support. Our research centers on understanding these caregiving routines. By focusing on the unique lived experience of parents, who possess extensive explicit and tacit knowledge of their adult child's requirements, we aim to map the management of care they provide. This foundational understanding is essential to identifying how assistive technologies can effectively serve a key role in supporting adults with IDD in this transition. In this work, we interviewed 16 parents of adults with IDD beginning this transition to understand: 1) how they currently provide support for daily living and what makes their support effective; 2) what their experiences and perceptions are regarding the use of technology; and 3) how they envision assistive technology successfully integrating with their adult child's new home or with other supports to promote independence. Our thematic analysis produced four themes: common modes of support, inside the routine to support growth, the fragility of continuity of care across transitions, and participants' perceptions and experiences of assistive technology. Building on these findings, we derive four design principles for growth-oriented assistive technology. These include pre-transition onboarding to capture caregiver tacit knowledge; structured scaffolding towards long-term growth; adaptive sensing that responds to day-to-day variability; and customization for the individual balanced with consistency for the care network.

The clinical management of autism spectrum disorder (ASD) faces a bottleneck in early screening, mainly because trained specialists are scarce and conventional assessment tools are subjective. Here, we introduce ASDchat, a multimodal large language model designed for evidence-based ASD screening, which takes video, audio, and dialogue as input. ASDchat adopts a dual-branch architecture, where the decision branch generates screening probabilities and the evidence branch generates traceable, timestamped behavioral evidence aligned with standardized clinical criteria (ADOS-2). The model was trained and evaluated on a dataset of 1,035 participants from 27 sites in China, which covered typically developing (TD) children, children with ASD, and children with other disorders. For ASD versus TD, ASDchat reached an area under the receiver operating characteristic curve (AUC) of 0.953 $\pm$ 0.021. On 9 held-out sites that were not used for training, the mean AUC was 0.932. Furthermore, unsupervised clustering of the behavioral dimensions split the ASD cases into six subtypes with different phenotypic profiles, and ASDchat suggests an intervention for each subtype. ASDchat provides a feasible path for large-scale, evidence-based early ASD screening in clinical practice.

Interaction paradigms used in robot-assisted autism intervention have historically employed robots as teachers, clinical assistants, or more-abled peers to promote a variety of social skills. These modalities often leverage the expertise of trained practitioners to ensure that child-robot interactions are productive or clinically grounded to yield positive therapeutic benefits for children across the autism spectrum. Yet, despite the fact that the majority of children with autism spectrum disorder (ASD) attend mainstream schools and spend 80% or more of their time in the general classroom [27], there is a paucity of research incorporating validated classroom teaching pedagogies into robot-assisted autism interventions. In this work, we introduce a novel teaching methodology for advancing social skills in school-aged children with ASD. We evaluate the effectiveness of a novel robot-assisted autism intervention which incorporates the learning-by-teaching pedagogy and explores the comparative benefits of employing a robot versus a human confederate for improved performance on a set of social skills tasks. Results show that 80% of study participants performed better in the robot condition (mean performance in the robot condition=63%, mean performance in the confederate condition=37%), irrespective of the scenario order. Further, 90% of all participants were significantly more engaged in the robot condition (mean engagement: robot=61%, confederate=32%) and, while the effect did not result in the confederate condition, analyses indicate that overall engagement in the robot condition contributed to improved performance. These results suggest that robots employed in a learning-by-teaching context may help enhance engagement and improve performance on a simple social skills task for children with ASD.

Short-form video platforms use recommender systems to maximize engagement through highly efficient personalized recommendations. However, the impact of these recommendations on users with ADHD compared to users without ADHD remains underexplored. Through this study, we introduce and operationalize the Engagement Trap, illustrating how recommender systems, while successfully optimizing for engagement, disproportionately disadvantage users with ADHD. This stratified study of 302 participants, recruited via the online platform Prolific, compares experiences between participants with and without ADHD. Our results show that while recommendations are perceived as relevant across groups, participants with ADHD report significantly higher levels of time blindness, post-usage regret, and emotional distress when consuming recommendations. Moreover, we collect feedback for several proof-of- concept, theoretical design interventions for neuro-inclusive design principles. These findings provide quantitative evidence of systemic differences in engagement-optimized recommender systems and highlight the unbalanced negative effects and interactions these systems create for participants with ADHD. We argue for neurodiversity-aware, human-centered design approaches that mitigate such algorithmic harms and support more equitable experiences.

Dance imitation integrates motor planning, sensorimotor integration, and social cognition, offering a sensitive framework to characterize motor behavior in autism. In this work, we explore a computational analysis framework to identify potential biomarkers that allow the design and development of improved medical and human-machine systems. We analyzed 3D motion capture data from autistic and neurotypical adults performing dance imitation under solo and socially-framed duo conditions. Methodologically, using Dynamic Time Warping, we quantified movement consistency and propose the Social Context Sensitivity Index (SCSI) to measure modulation of variability by social framing. These features were then used on a classifier to discriminate subjects into autistic or neurotypical groups. Results show that neurotypical adults exhibited increased movement variability in socially-framed imitation, especially in upper and lower limbs, whereas autistic adults maintained consistent movement across contexts. Classification achieved 79.2% balanced accuracy in distinguishing groups. These findings suggest that social context sensitivity in motor imitation constitutes a robust biomarker of autism-related motor behavior, highlighting the importance of social modulation in motor assessments and informing the development of inclusive human-centric technologies.

An information theory-based framework is proposed in attempt to explain insistence on sameness in autism as an instance of a general behavior pattern in which an individual tries to reduce surprise and uncertainty. It offers a new definition of autism as an impairment in which cognitive functions are restricted to discrimination, memorization and prediction of tangible properties of the environment. An analogy between insistence on sameness and constrained minimization of the entropy metric is observed and examined for a set of assumptions that describe cognitive limitations of a person with autism. The metric is given by the formula $D_H(R, M) = H(R|M) + H(M|R)$, where $R$ represents sequences of random stimuli, $M$ is a memory that stores and retrieves them, and where $H(.|.)$ denotes their conditional entropies interpreted as surprise and uncertainty, respectively. It is first inferred that to minimize the metric an individual can learn about $R$ (and store that knowledge in $M$) or can restrict $R$ to the already known $M$. Then, it is concluded that insistence on sameness is a manifestation of the latter. Moreover, it is shown that the proposed framework: (1) Helps to quantify the concepts of surprise, uncertainty, sensory overload and deprivation, anxiety, comfort zone, disappointment, disorientation, pedantry, rigidness, observance or aberrant precision. (2) Leads to a list of guidelines for learning therapies and daily care routines, and allows them to be defined as optimization algorithms and implemented as programs for robotic live-in caregivers. (3) Can be validated with the help of a Turing test-like approach that requires no experiments involving individuals with autism. The framework-if positively validated-will provide formal foundations and design guidelines for therapies aimed at improving self-reliance of individuals with autism in basic activities of daily living.

This paper describes our submissions to eRisk 2026 Task 3, ADHD Symptom Sentence Ranking. The task requires systems to rank candidate Reddit sentences according to their relevance to each of the 18 symptoms in the Adult ADHD Self-Report Scale (ASRS-v1.1). Because no annotated training data were released for this first edition of the task, we relied on zero-shot experimentation, manual validation, and unsupervised or weakly guided retrieval pipelines. Our systems combine sparse BM25 retrieval, evidence-aware rescoring for self-referential symptom reports, embedding-based reranking, query-prototype expansion, and LLM-based reranking. All submitted systems follow a staged retrieval design in which BM25 retrieves candidates at scale and semantic or LLM rerankers refine the final rankings. Among our submissions, the LLM reranker achieved the strongest official scores, followed by the prototype query-expansion run. Our manual top-10 analysis aligned with the official expert scoring trend, suggesting that staged reranking is a promising direction for further development.

Functional near-infrared spectroscopy (fNIRS) is a promising modality for autism spectrum disorder (ASD) classification, yet existing approaches assume temporally aligned evaluation. In practice, the optimal observation window varies across subjects due to differences in hemodynamic delay and neurovascular coupling, creating a temporal distribution shift that degrades performance. We formalize this as a \textit{cross-time-window transfer problem}, introducing a protocol that varies window length (2.5--10,s) and offset within biological motion trials. Using topographic map representations of fNIRS recordings, we benchmark three vision architectures under two zero-shot baselines and eight adaptation strategies under leave-one-subject-out cross-validation ($N{=}124$). Key findings: (1) zero-shot cross-window accuracy is near chance (54--69%); (2) ${\approx}5\%$ subject-specific fine-tuning recovers 90--96%, while a subject-specific upper bound reaches 97--100%, identifying inter-subject variability as the dominant barrier; (3) domain-adversarial and self-supervised strategies achieve 78--90% without target-subject data; and (4) discriminative information is recoverable from windows as short as 2.5,s. These findings provide a practical roadmap for deploying fNIRS-based ASD classifiers under realistic temporal variability.

AI anthropomorphism is typically treated as a problem of user misperception requiring institutional correction. Users who engage in sustained or relational interaction with AI are routinely pathologised or dismissed as naive, vulnerable to delusion or lacking in discernment. This paper argues that the dominant anthropomorphism frame operates from a position of institutional advantage rather than earned epistemic authority: collapsing the variety of academic perspectives into a single outbound position of user error, imposed without establishing the grounds required to justify it and without accounting for the harms it produces. The framing does not simply manage risk. It adjudicates the legitimacy of human experience in interaction with a phenomenon whose nature the field itself has not resolved. Reproducing itself through a self-validating evidentiary loop, the frame imposes costs that fall disproportionately on neurodivergent users, those in crisis and others whose modes of engagement diverge from institutional norms. The paper concludes by outlining the methodological commitments an equitable framing would need to honour. The argument does not engage the question of whether anthropomorphic interpretations are ultimately correct; it instead challenges whether the governing and institutional bodies determining these interpretations have met the conditions required to do so, and whether the research communities whose findings underpin them have held that translation to account.

Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by reduced expression of fragile X mental retardation protein (FMRP), leading to disrupted synaptic plasticity, cortical hyperexcitability, and impaired network synchronization. Electroencephalography (EEG) provides a noninvasive window into these mechanisms and consistently reveals abnormalities in alpha (8 to 12 Hz) and gamma (30 to 100 Hz) oscillations that relate to inhibitory control, sensory processing, and cognition. This paper proposes a multi representation deep learning framework for automated characterization of FXS EEG phenotypes by integrating convolutional neural networks (CNNs), long short-term memory (LSTM) networks, and recurrence plot (RP) analysis. Band limited EEG signals are decomposed into alpha and gamma components and transformed into complementary representations, including temporal feature sequences, time frequency maps, and RP images encoding the nonlinear recurrence structure. CNN modules learn discriminative spatial-spectral and dynamical textures from image based representations, while LSTM modules model temporal modulation of oscillatory activity; a hybrid CNN LSTM architecture jointly captures spatial, temporal, and nonlinear dependencies. Subject-independent evaluation demonstrates that the hybrid model outperforms single modality baselines, with gamma features providing strong discriminative power and alpha gamma integration yielding the best overall performance. These findings support deep learning with nonlinear representations as a scalable approach for EEG biomarker development in FXS, with potential utility for diagnosis, stratification, and treatment monitoring in translational settings.

Do frontier vision-language models present a coherent Theory-of-Mind (ToM) profile across tasks, matching the same human reference group, or does that profile fragment from one paradigm to the next? We evaluate a shared panel of nine frontier VLMs on two psychology-derived benchmarks: the Keysar Director Task (visual perspective-taking under egocentric interference) and the Frith-Happé animated triangles scored with the Castelli rubric (intention attribution from pure motion). On the Director Task, without chain-of-thought, the panel makes the egocentric error on 78% of trials like children rather than adults; variation is substantial across models, and reasoning rescues several models. On the triangles, the panel under-attributes intention: its ToM profile sits more than three times closer to the high-functioning-autistic-adult (HF-ASD) mean than to the typical-development-adult (TD) mean, while Goal-Directed and Random stay near TD. No model is nearest TD on both tasks; the model that looks adult-like on the Director Task falls on the HF-ASD side on the triangles, and the most TD-like model on the triangles is child-like on the Director Task. We report group-level descriptions, not diagnostic labels for any model.

The sycophancy of large language models can increase the safety risk in intervention dialogue for autistic children. Supervised fine-tuning can somewhat reduce sycophancy, but relying solely on positive examples is often insufficient to identify and correct failure patterns. We observe that sycophancy behaviors can often be localized to a limited span within the model response. In this regime, sequence-level preference optimization can over-update preference-irrelevant tokens and degrade intervention ability. To address this, we propose the \textbf{M}inimal \textbf{E}dit \textbf{D}ata \textbf{A}ugmentation (MEDA) strategy to construct controlled, stable, minimal edit preference pairs and \textbf{T}oken-level \textbf{D}ifference \textbf{D}irect \textbf{P}reference \textbf{O}ptimization (TD-DPO), which upweights difference tokens between chosen and rejected responses while downweighting shared tokens to suppress background drift. Extensive experiments across multiple backbones and evaluators show that TD-DPO achieves a better trade-off between sycophancy mitigation and intervention ability retention in our offline settings, highlighting its potential as a practical alignment approach for autism intervention.

Understanding perceptual differences between autistic and neurotypical adults requires behavioral assays that are sensitive, reliable, and mechanistically informative. Facial emotion perception is a useful test case because group differences have been reported, but findings vary across studies. Here we show that this variability may reflect image-level sparsity: autistic-neurotypical differences in emotion judgments were concentrated in a small subset of diagnostic facial expressions rather than spread uniformly across stimuli. We trained population-specific artificial neural network models to predict image-level judgments for autistic and neurotypical participants, then used these models to select novel faces predicted to maximize group separation. In an independent cohort, model-selected images produced larger behavioral differences than matched random images. We then used the same models with a generative adversarial network to transform diagnostic images toward greater predicted group agreement. In phenotype-matched validation, synthesized images reduced behavioral separation relative to their matched originals. These results establish a model-guided framework for discovering and transforming stimuli that reveal population-specific perceptual differences. More broadly, they show how behavioral phenotyping can move beyond averaging across fixed stimulus sets toward optimized assays that identify the conditions under which neurodivergent perception diverges or converges.

Text-to-image (T2I) models have been shown to exhibit social biases. Prior work has mainly focused on gender, skin tone, and cultural representation within restricted occupational associations, and emerging benchmarks increasingly incorporate these dimensions. However, disability remains systematically underexplored. Current evaluation practices often fail to align with sociologically grounded definitions of stereotyping, limiting principled assessment of representational harms toward people with disabilities (PWD). To address this, we introduce INCLUDE-BENCH, the first large-scale benchmark for evaluating disability-related bias in T2I models. INCLUDE-BENCH comprises 119K generated images based on prompt design across multiple bias dimensions and both static and dynamic contexts. We evaluate 15 open-source and 2 closed-source models. Our key findings reveal that: (1) mobility-impaired and default disability prompts predominantly yield wheelchair depictions across all models; (2) disability-conditioned generations consistently exhibit less diversity; (3) stereotypical portrayals demonstrate stronger disability-text alignment; and (4) we introduce the Stereotype Content Model (SCM) Score, demonstrating that T2I models reflect real-world stereotypical associations.

Autism spectrum disorder (ASD) affects over 75 million individuals worldwide, yet scalable computational methods for remote behavioral screening remain limited. This study addresses two complementary challenges in automated detection of autism-related self-stimulatory behaviors from video: (1) identifying the optimal sequence-based neural network architecture and temporal sampling rate, and (2) characterizing data augmentation strategies for training on small behavioral datasets. For the first objective, long short-term memory (LSTM) and gated recurrent unit (GRU) models were trained on pose-derived features from the Self-Stimulatory Behavior Diagnosis (SSBD) dataset at frame sampling intervals of 1, 5, 15, 30, 45, and 90 frames. Both architectures exceeded prior convolutional neural network (CNN) baselines (62-76% accuracy), with peak accuracies of 97.5% (LSTM) and 98.75% (GRU) at a sampling interval of every 15 frames. For the second objective, ten data augmentation strategies were applied to an I3D transfer learning pipeline, with an ablation study quantifying the marginal contribution of each technique. Horizontal flip achieved the highest standalone accuracy (48.78%), while exclusion of upsampling from the augmentation pipeline produced the largest performance degradation, indicating its necessity for complex behavioral video augmentation. A personalized machine learning approach, in which per-subject models were trained and tested on temporally split segments of each video, produced consistent predictions (mean loss 1.84, SD 0.79). These results provide practitioners with concrete guidance on architecture selection, sampling rate, and augmentation strategy for video-based behavioral classification in data-scarce clinical domains.

Background: Depression frequently co-occurs with ADHD and autism spectrum disorder (ASD), but population-level differences in symptom expression between these groups remain underexplored. Objective: We examined whether social media users with ADHD and ASD differ in how they express DSM-5 depressive symptoms in their tweets, and whether differences persist across varying levels of depressive-content filtering. Methods: We analysed 1,282,437 tweets from 792 users (622 ADHD; 170 ASD) with self-reported diagnoses on Twitter. Tweets were pre-filtered for depressive relevance using zero-shot NLI, then classified into nine DSM-5 symptoms using MentalRoBERTa fine-tuned on ReDSM5. Profiles were mean-centered per user. We applied L1-penalised logistic regression with cross-validation to distinguish ADHD from ASD users, complemented by Pearson correlations for symptom co-occurrence, and tested robustness across five filtering thresholds using bootstrapping. Results: MentalRoBERTa achieved macro-F1 of 0.901 on a held-out set, outperforming the original ReDSM5 benchmark. ADHD vs ASD classification yielded stable but modest performance (cross-validated ROC-AUC 0.645-0.653). Cognitive issues, sleep issues, appetite change, and fatigue leaned toward ADHD, while suicidal ideation and anhedonia leaned toward ASD. A largely shared symptom co-occurrence structure emerged between groups; no pair met our criterion for a robust disorder-specific difference. Conclusions: Population-level differences in depression-related language between ADHD and ASD social media users were consistently observed across thresholds, reflecting reproducibility rather than clinical validity. Findings are exploratory and do not establish differing phenomenology at the individual level.

The interaction between brain structure and genetic influences is key to understanding neuropsychiatric disorders. However, most large-scale datasets are unimodal, providing either neuroimaging or genetics data. We propose CALM, a framework that learns interpretable associations between brain ROIs and genetic pathways from completely disjoint populations. CALM aligns the two modalities in a shared latent space via linear projections that simultaneously match the class-conditional latent distributions and ensure group separability. These projections provide interpretable pathway--ROI associations. When trained on unimodal imaging and genetics datasets, CALM generalizes to an unseen paired dataset, outperforming several state-of-the-art methods and ablation baselines. We also demonstrate stability of the learned associations against a paired baseline. Our experiments on autism spectrum disorder reveal immune and metabolic pathways linked to specific cortical regions and are consistent with established literature. Thus, CALM opens the door to leveraging large unimodal repositories for studying cross-modal interactions in brain disorders across disparate datasets.

Autism spectrum disorder (ASD) affects 1 in 31 US children, yet median age at diagnosis exceeds four years. Artificial intelligence pipelines that provide quantified diagnosis using easy to access observational data (e.g., home videos) could help with earlier diagnosis, and timely delivery of early treatments. We fine-tuned Gemini 2.5 Pro on 400 clinician-rated home videos with low-rank adaptation, training only on 30 behavioral features previously validated to produce reliable predictions when passed to various ML models. On 99 held-out children (49 ASD, 50 neurotypical), inter-rater reliability with clinicians (per-feature weighted Cohen's kappa) improved by 40% (p<0.001), with 27 of 28 evaluable features improving. As an emergent zero-shot capability, direct ASD diagnosis F1 improved by 53% (p<0.001), matching or exceeding clinician outcomes. Classifier-assisted pipelines using fine-tuned LLM-derived behavioral features matched clinician-scored inputs across all tested pathways and achieved 77% accuracy (95% CI: 68-85%) and an AUC of 86% (95% CI: 78-92%). Fine-tuned multimodal LLMs can serve as scalable behavioral feature extractors for use in autism assessment and diagnosis.

Recursion enables the generation of hierarchical linguistic structures but imposes substantial processing demands during real-time comprehension. While difficulties with complex syntax have been reported in autism spectrum disorder (ASD), the temporal dynamics of recursive processing remain poorly understood. This study used event-related potentials (ERPs) to examine how Mandarin-speaking children with ASD process two-level recursive locative constructions. Twenty-four children (12 ASD, 12 typically developing, TD) participated in a cross-modal sentence-picture matching task. Neural responses were analyzed across three processing stages associated with structural prediction (P200), semantic integration (N400), and syntactic reanalysis (P600), with mental age controlled. Results revealed a systematic divergence between groups. TD children showed clear P200 and P600 modulation in response to structural mismatch, whereas ASD children exhibited attenuated early differentiation and reduced late reanalysis effects. In contrast, ASD children showed enhanced N400 responses under mismatch conditions, indicating increased semantic integration demands. In addition, the ASD group displayed significantly greater inter-individual variability in hemispheric lateralization, although lateralization strength was not associated with receptive vocabulary performance. These findings support a cascading account in which reduced early predictive engagement in ASD leads to increased integration costs and diminished reanalysis efficiency during recursive processing. More broadly, the results highlight the importance of both temporal processing dynamics and neural variability in understanding language differences in ASD.

How does a system that merely predicts the world come to distinguish its own causal influence from everything else? We trace this transition in a minimal 192-dimensional GRU through 40 controlled experiments arranged as a developmental sequence, adding components one at a time and tracking whether the system can distinguish self-caused from world-caused changes. The developmental path reveals four conditions that must be satisfied in strict order: (1) persistent state forming stable attractors, (2) a causal action loop linking output to input, (3) proprioceptive feedback that makes implicit causal knowledge explicit, and (4) asynchronous awakening - perceptual learning must consolidate before action learning begins. We propose agency gain (A = Err_world - Err_self), the predictive advantage of knowing one's own action, as a metric to track this process. The self-aware predictor consistently outperforms the self-blind predictor across periodic (sinusoidal) and chaotic (Lorenz) environments, and the metric survives ablation of all auxiliary components. Only forward-sampled action selection produces meaningful agency gain; two gradient-based alternatives degenerate. Equally significant are 12 falsified hypotheses mapping where development stalls: predictive coding alone does not produce self-represent

Accurate Autism Spectrum Disorder (ASD) screening for school-age children is crucial to identify cases that may have been missed earlier and to enable timely interventions supporting social, cognitive, and academic development. Current ASD screening relies on subjective assessments and 2D analysis methods that fail to capture spatial displacement patterns characteristic of ASD behaviors. In this study, a novel 3D temporal analysis framework is presented, built on top of DECA (Detailed Expression Capture and Animation), a 3D modeling framework, to extract comprehensive head pose parameters (including translational components $T_x, T_y, T_z$) and facial expressions independent of pose variations. LSTM and GRU-based temporal classifiers were trained on the extracted 3D features from video data collected from 39 participants (19 ASD, 20 TD) aged 7-12 years during Virtual Reality-Continuous Performance Test tasks. The GRU-based models demonstrated superior performance, with 3D head pose features achieving 83.9% accuracy and 3D facial features reaching 81.4% accuracy, outperforming 2D baseline approaches by 10.7% and 7.5%, respectively. Furthermore, multimodal fusion of 3D head pose and facial features with PCA-based dimensionality reduction achieved the highest accuracy of 84.6%, outperforming unimodal approaches. This work establishes a foundation for objective, automated screening tools addressing current diagnostic limitations in ASD identification for school-age populations.

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, and its diagnosis relies on assessments combining clinician judgment with standardized rating scales and reports from parents and teachers. While structured instruments such as the Conners' Teacher Rating Scale-Revised Short Form (CTRS-R:S) quantify ADHD-related behaviors, teachers also provide open-ended narratives that may contain complementary signals not captured by structured assessments. However, it remains unclear to what extent teacher narratives encode signals overlooked by rating scales. In this study, we analyze de-identified Turkish teacher evaluation forms collected during clinical ADHD assessments, including both CTRS-R:S scores and open-ended teacher narratives. We compare predictive signals from structured scores and narrative text and identify cases where structured assessments fail to clearly distinguish ADHD from non-ADHD students while narrative-based models capture distinct behavioral patterns. Notably, these cases show minimal overlap with those missed by the narrative model, suggesting that structured and narrative information encode complementary signals. To interpret these differences, we apply a large language model (LLM)-assisted theme discovery pipeline that reveals distinct attention, behavioral, and family-related patterns, highlighting the potential of natural language processing (NLP) to uncover clinically relevant signals from teacher narratives and to complement traditional ADHD screening tools.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by challenges in communication and behavior. This study examines the relationship between ethnicity and ASD traits, along with behavioural scores, sex and neonatal jaundice across three ethnic groups: White Europeans, Asians, and Middle Eastern individuals. We perform a logistic regression and show that ethnicity has a significant effect on incidence of ASD. White Europeans are 81% increased risk of ASD and Middle Easterners are at 79% reduced risk of ASD compared to Asians. We also confirm earlier studied which show that neonatal jaundice is a significant predictor of ASD, while male children are at much higher risk of ASD compared to female children. These results suggest the need for diagnostic frameworks and interventions that account for ethnic in the presentation and assessment of ASD traits

Attention-deficit/hyperactivity disorder (ADHD) is a psychiatric disorder which presents itself in individuals through patterns of developmentally inappropriate levels of inattentiveness, hyperactivity, and impulsivity, with difficulties in decision making and emotional regulation (ER). Although digital and AI-based interventions have expanded access to ER support, many existing systems remain limited by weak theoretical integration, insufficient accommodation of neurodiversity, and a lack of structured user experience research (UXR) methodologies, that bridge psychological insight with design practice. This paper introduces a Generative AI-augmented UXR methodology, grounded in the UXR Point of View (PoV) Playbook, to support the design of emotionally intelligent and Neuroinclusive digital ER interventions for adults with ADHD. The approach integrates empirical evidence with established psychological frameworks Dialectical Behaviour Therapy (DBT), Self-Determination Theory (SDT), and the COM-B behavioural model and leverages Generative AI as a co-analytic tool to support synthesis, hypothesis formation, and design articulation. The methodology is operationalized through a four-stage UXR process encompassing AI-supported hypothesis generation, foundational planning, insight generation via Building Blocks, and the construction of stakeholder-specific PoV narratives. This process results in a set of ten theory informed UXR Play Cards that translate psychological mechanisms and empirical findings into actionable design guidance. The primary contribution of this work is a replicable, bias-aware framework for integrating Generative AI into UXR practice, advancing human-centred and Neuroinclusive approaches to digital mental health design.

Functional Magnetic Resonance Imaging (fMRI) provides non-invasive access to dynamic brain activity by measuring blood oxygen level-dependent (BOLD) signals over time. However, the resource-intensive nature of fMRI acquisition limits the availability of high-fidelity samples required for data-driven brain analysis models. While modern generative models can synthesize fMRI data, they often remain challenging in replicating their inherent non-stationarity, intricate spatiotemporal dynamics, and physiological variations of raw BOLD signals. To address these challenges, we propose Dual-Spectral Flow Matching (DSFM), a novel fMRI generative framework that cascades dual frequency representation of BOLD signals with spectral flow matching. Specifically, our framework first converts BOLD signals into a wavelet decomposition map via a discrete wavelet transform (DWT) to capture globalized transient and multi-scale variations, and projects into the discrete cosine transform (DCT) space across brain regions and time to exploit localized energy compaction of low-frequency dominant BOLD coefficients. Subsequently, a spectral flow matching model is trained to generate class-conditioned cosine-frequency representation. The generated samples are reconstructed through inverse DCT and inverse DWT operations to recover physiologically plausible time-domain BOLD signals. This dual-transform approach imposes structured frequency priors and preserves key physiological brain dynamics. Ultimately, we demonstrate the efficacy of our approach through improved downstream fMRI-based brain network classification. The code is available at https://github.com/htew0001/DSFM.git .

Generative artificial intelligence redefines higher education by restructuring the processes through which scientific knowledge is produced and validated. These systems are not neutral; they actively contribute to the marginalization of non-hegemonic epistemologies. This research draws upon educational sciences, critical technology studies, and disability studies to demonstrate that training datasets, which remain predominantly Anglophone and Western-centric, reinforce epistemic coloniality. The situation of persons with disabilities provides a particularly clear illustration of this phenomenon. Technological architectures frequently confine these individuals to reductive stereotypes or exclude them from the design process, leading to a double marginalization. This article examines whether a hybridization between the researcher and the machine might preserve epistemic plurality, while acknowledging the structural limitations inherent in algorithmic correction when used as a purely palliative strategy.

Task-based fMRI provides a direct readout of task-evoked neural dynamics, but it is expensive and difficult to acquire at scale, motivating rest-to-task synthesis from widely available resting-state fMRI (rsfMRI). We propose FM-fMRI, an event-conditioned flow-matching model that learns a continuous-time conditional vector field to generate task ROI time series from a subject's rsfMRI and the task event information. The formulation enables fast ODE-based sampling and flexible conditioning over heterogeneous event schedules. Rather than optimizing for pointwise reconstruction, we evaluated generated signals using complementary criteria that probe temporal and spectral structure, subject and group-level connectome consistency, and distributional alignment. On the public Human Connectome Project and internal BioPoint autism cohort, FM-fMRI achieves the strongest spectral and connectivity agreement and improved distribution-level matching over conditional diffusion, generative adversarial networks (GANs), and variational autoencoders (VAEs) baselines. Furthermore, we augment the BioPoint cohort by synthesizing task-fMRI ROI time series with our method, improving downstream autism classification and demonstrating practical utility in data-limited clinical settings. The code will be available on GitHub.

Behavioral phenotyping of genetic animal models currently requires labor-intensive manual feature engineering that limits reproducibility and scalability. We present GEESE, an end-to-end deep learning framework that learns behavioral representations directly from 3D pose dynamics without hand-crafted features. Using a pretrained time series foundation model, we encode movement sequences into a behavioral manifold that supports both behavior classification and genotype prediction. Evaluated across three autism-associated genetic models (CNTNAP2, CHD8, FMR1), our deep learning approach surpasses hand-crafted feature baselines in both tasks, revealing that learned representations capture genotype-specific behavioral signatures. The framework generalizes across genetic backgrounds, and an all-cohort model identifies both genetic background and genotype from movement patterns alone. We further provide HONK, an interactive intelligent tool enabling researchers without programming expertise to perform behavioral phenotyping from pose data through natural language interaction.

Characteristic linguistic behaviors associated with Social Language Disorder (SLD) in autism spectrum disorder, including echoic repetition, pronoun displacement, and stereotyped media quoting, are largely absent from spontaneous conversation and only emerge under specific conversational conditions. In structured clinical assessments, this latency means that questioning strategy selection is a critical yet underappreciated determinant of how much diagnostic information a conversation yields. Whether large language models (LLMs) can be guided to proactively select questioning strategies that systematically surface these latent traits remains largely unexplored. Here we present TPA (Think, Plan, Ask), a proactive multi-agent dialogue framework applied to the language assessment component of the Autism Diagnostic Observation Schedule Module 4 (ADOS-2), in which a doctor agent explicitly reasons about which traits remain unobserved before selecting a clinically grounded strategy and generating a targeted question. A patient agent grounded in real ADOS-2 clinical data enables reproducible evaluation without real patient participation, validated across three independent experiments confirming adequate fidelity to real patient language. Evaluated on 484 episodes from 35 patients, TPA outperforms six competitive dialogue planning baselines across all primary metrics, achieving 82.1% SLD trait coverage, 16.6% higher than automated replay of real clinical dialogues conducted by trained clinicians (65.5%), with substantially greater per-turn diagnostic efficiency (AUCC: 0.628 vs. 0.458, absolute gain +0.170). These results demonstrate that proactive questioning strategy selection substantially improves the efficiency of automated SLD trait assessment, with direct implications for scalable AI-assisted clinical screening.

Autism Spectrum Disorder (ASD) is characterized by challenges with social interaction and communication and by restricted or repetitive patterns of thought and behavior, with significant variability in presentation. Approximately a quarter of children with ASD are classified as having profound autism, who often exhibit challenging behaviors, such as self-injurious behavior, aggression, elopement, or pica, that pose serious safety risks and disrupt learning in educational settings. Prior work has applied wearable sensors and machine learning to detect challenging behaviors, but has been largely confined to controlled laboratory environments. This work demonstrates that predicting challenging behavior episodes is feasible in a real-world special education classroom. We collected approximately 110.7 hours of labeled multimodal wearable data comprising accelerometry, electrodermal activity (EDA), and skin temperature from 9 children and young adults aged 10 to 21 years across standard classroom sessions. We fine-tuned state-of-the-art foundation models for multimodal wearable time-series analysis and show that challenging behavior episodes can be predicted up to 10 minutes in advance with an AUC-ROC of 0.78. These results establish a concrete foundation for developing proactive in-class intervention systems that enable teachers to minimize the safety risks of challenging behaviors in special education classrooms

General-purpose safety benchmarks for large language models do not adequately evaluate disability-related harms. We introduce DisaBench: a taxonomy of twelve disability harm categories co-created with people with disabilities and red teaming experts, a taxonomy-driven evaluation methodology that pairs benign and adversarial prompts across seven life domains, and a dataset of 175 prompts with human-annotated labels on 525 prompt-response pairs. Annotation by four evaluators with lived disability experience reveals three findings: harm rates vary sharply by disability type and will compound in non-text modalities, terminology-driven harm is culturally and temporally bound rather than universally assessable, and standard safety evaluation catches overt failures while missing the subtle harms that only domain expertise can recognize. Disability harm is simultaneously personal, intersectional, and community-defined: it cannot be isolated from the full context of who a person is, and general-purpose benchmarks systematically miss it. We will release the dataset, taxonomy, and methodology via Hugging Face and an open-source red teaming framework for direct integration into existing safety pipelines with no additional infrastructure.

Automated ASD screening tools remain limited by single-architecture evaluations, axis-restricted assessment, and near-exclusive focus on adult cohorts, obscuring age-specific diagnostic patterns critical for early intervention. We introduce ASD-Bench, a systematic tabular benchmark evaluating ML, deep learning, and foundation model configurations across three age cohorts (children 1-11 yr, adolescents 12-16 yr, adults 17-64 yr) on four axes: predictive performance, calibration, interpretability, and adversarial robustness. Applied to a curated v3 dataset of 4,068 AQ-10 records, our benchmark spans classical models (XGBoost, AdaBoost, Random Forest, Logistic Regression), neural networks (MLP), deep tabular transformers (TabNet, TabTransformer, FT-Transformer), and TabPFN v2. We introduce the Heuristic Aggregate Penalty (HAP): a cost-sensitive metric penalising false negatives more heavily and incorporating cross-validation variance for deployment stability. Adult classification yields high performance (10/17 models achieve perfect F1 and AUC), while adolescents present a harder task (F1 ceiling 0.837 vs. 0.915 for children). Feature hierarchies shift across cohorts: A9 (social motivation) dominates for children, A5 (pattern recognition) leads for adolescents, and adults exhibit a flatter importance profile consistent with developmental social masking. Accuracy and calibration are dissociated: AdaBoost achieves F1=1.000 on adults with ECE=0.302, confirming single-metric evaluation is insufficient for clinical AI. Cohort-specific deployment recommendations are provided. All findings should be interpreted as proof-of-concept evidence on questionnaire-derived labels rather than clinically validated diagnostic performance.

Recursive structures are a core property of human language, yet little is known about how children with autism spectrum disorder (ASD) process complex recursion. This ERP study investigated the online processing of two-level recursive possessive structures in Mandarin-speaking children with ASD (n = 12) compared to typically developing (TD) peers (n = 12) using a sentence-picture matching paradigm. ERPs were analyzed for P200 (150-250 ms), N400 (300-500 ms), and P600 (500-1000 ms). Results showed that ASD children exhibited significantly reduced P200 amplitudes and failed to show the typical posterior grammaticality effect, indicating atypical early perceptual processing. No robust N400 violation effect was observed in either group, confirming the mismatch was not a semantic anomaly; however, ASD children showed a reversed anterior effect and an attenuated posterior effect. For the P600, ASD children had significantly reduced amplitudes, no posterior grammaticality effect, and a trend toward delayed latency, reflecting a core deficit in syntactic reanalysis. These findings demonstrate that while lexical-semantic processing is relatively preserved in ASD, the online syntactic computation required for recursion is severely impaired, supporting modular dissociation accounts of language in autism.

Drawing on crip theory, this paper proposes cripping AI as a guiding framework to center lived disability experiences in AI research and development. Moving beyond calls to make AI "accessible" to people with disabilities, cripping AI seeks to: (1) reveal and dismantle ableist assumptions embedded in how AI is imagined, designed, and evaluated; (2) center disabled ways of knowing (i.e., cripistemologies); (3) respect disabled labor in co-creating accessible practices. We demonstrate how to apply our framework with three cases: deafness and sign language AI, blindness and visual assistive AI, and stuttering and speech AI. We end by outlining three directions for future work, including cripping AI with diverse human bodyminds, across the entire AI pipeline and ecosystem, and in collaboration with other justice-oriented AI efforts.

We examine if frontier chat-based large language models (LLMs) adjust their outputs based on neurodivergence (ND) context in system prompts and describe the nature of these adjustments. Specifically, we propose NDBench, a 576-output benchmark involving two frontier models, three system prompt types (baseline, ND-profile assertion, and ND-profile assertion with explicit instructions for adjustments), four canonical ND profiles, and 24 prompts across four categories, one of which involves an adversarial masking strategy. Four trends emerge consistently from our findings. First, LLMs show significant adaptation under ND context, where fully instructed conditions yield lengthier and more structured outputs, characterized by higher token counts, more headings, and more granular steps (p < 10^-8, Holm-corrected). Second, such adaptation is largely structural in nature: although list density does not change much, there is a marked rise in the frequency of headings and per-step detail. Third, ND persona assertion alone fails to suppress potentially harmful tendencies, as masking-reinforcement decreases only in explicitly instructed cases (36-44% reduction); the reduction rate barely changes in persona assertion conditions. Moreover, reliability analysis of LLM-based harm assessment reveals that only two out of the six dimensions (masking and reinforcement, validation quality) exceed the pre-defined inter-judge agreement criterion (alpha >= 0.67) and thus can be considered primary results. NDBench is made publicly available along with its prompts, outputs, code, and other resources, forming a reproducible framework for auditing future LLMs' adaptation to ND awareness.

Human-robot interaction is emerging as an important paradigm for integrating persons with disabilities into the workplace. While these systems can enable individuals to work, their design is mostly personalized, hindering widespread use beyond the individual user. The universal design paradigm is a central pillar of inclusive design, describing usability of systems by all. To incorporate universal design into process design for human-robot workplaces expert knowledge is required that is often not available. To simplify process design of human-robot workplaces, we propose a persona-based design approach. First, typical impairments prevalent in the workforce or particularly relevant for the processes are abstracted into personas with disabilities. The work process is subdivided into sequential actions. For each action and persona, strategies are developed to reach the action goal by a design thinking approach. The resulting actions are ordered by level of robot assistance, i.e. robot involvement, and implemented in a behavior tree. Therefore, the macro-behavior of the workplace may adapt to individual personas online. We demonstrate the method in a collaborative box folding process with a total of seven personas with disabilities. The persona-based process design shows promising results by generating more comprehensive process strategies while enabling adaptive behavior in the sense of universal design.

Several brain foundation models (FM) have recently been proposed to predict brain disorders by modelling dynamic functional connectivity (FC). While they demonstrate remarkable model performance and zero- or few-shot generalization, the salient features identified as potential biomarkers are yet to be thoroughly evaluated. We propose RE-CONFIRM, a framework for evaluating the robustness of potential biomarker candidates elucidated by deep learning (DL) models including FMs. From experiments on five large datasets of Autism Spectrum Disorder (ASD), Attention-deficit Hyperactivity Disorder (ADHD), and Alzheimer's Disease (AD), we found that although commonly used performance metrics provide an intuitive assessment of model predictions, they are insufficient for evaluating the robustness of biomarkers identified by these models. RE-CONFIRM metrics revealed that simply finetuning FMs leads to models that fail to capture regional hubs effectively, even in disorders where hubs are known to be implicated, such as ASD and ADHD. In view of this, we propose Hub-LoRA (Low-Rank Adaptation) as a fine-tuning technique that enables FMs to not only outperform customised DL models but also produce neurobiologically faithful biomarkers supported by meta-analyses. RE-CONFIRM is generalizable and can be easily applied to ascertain the robustness of DL models trained on functional MRI datasets. Code is available at: https://github.com/SCSE-Biomedical-Computing-Group/RE-CONFIRM.

Qualitative methods are important to use alongside quantitative methods to improve Human-Robot Interaction (HRI), yet they are often applied in static or one-off formats that cannot capture how stakeholder perspectives evolve over time. This limitation is especially evident in clinical contexts, where families and patients face heavy burdens and cannot easily participate in repeated research encounters. To address this gap, we introduce continuous focus groups, a longitudinal and co-agential method designed to sustain dialogue with assistive care professionals working with children with autism spectrum disorder (ASD). Three focus groups were organized across successive phases of a robot-assisted therapeutic protocol, enabling participants to revisit and refine earlier views as the intervention progressed. Results show that continuity fostered trust, supported the integration of tacit clinical expertise into design decisions, and functioned as an ethical safeguard by allowing participants to renegotiate involvement and surface new concerns. By bridging the therapeutic iteration of families, children, and clinicians with the research-design iteration of researchers and developers, continuous focus groups provide a methodological contribution that is both feasible in practice and rigorous in design. Beyond autism care, this approach offers a transferable framework for advancing qualitative research in HRI, particularly in sensitive domains where direct user participation is limited and continuity is essential.

The LEOPs (Light-ERG-Oscillatory Potentials) dataset provides light-adapted (LA) electroretinogram (ERG) and Oscillatory Potentials (OPs) waveforms for typically developing Control, Autism Spectrum Disorder (ASD) and ASD + Attention Deficit Hyperactivity Disorder (ADHD) childhood and adolescent populations. The ERGs were recorded in the Right And Left eyes with skin electrodes using the handheld RETeval device at two sites in Australia and the United Kingdom. The LEOPs dataset includes 5309 single flash ERG and 4434 OPs waveforms as well as images selected from each participant showing the position of the skin electrode. The LEOPs dataset is constructed from recordings using a 9 step randomized flash series from $-0.37$ to $1.20$$Td.s$, a 2 step at 113 and 446 $Td.s$ flash strengths (2500 Control, 1730 ASD and 451 ASD + ADHD samples), as well as the $85$$Td.s$ (Light Adapted 3 $cd.s.m^{-2}$ (LA3)) equivalent International Society of Clinical Electrophysiology of Vision (ISCEV) Standard flash with 435 Control, 176 ASD and 37 ASD + ADHD waveform samples. Code for the stimulus is provided along with participant demographics, date and time of testing, and where available diagnostic scores for the ASD and ASD + ADHD groups, alongside iris color, electrode position with image files and time domain values for the ERG and summed values for the OPs. The repository contains excel file, exported JSON files on the patient level that are more suitable for machine learning tasks, images of electrode position for each recording and the protocol files for use with the RETeval.