Developmental Trajectories

Artificial ontogeny, developmental encodings, robot reproduction, and inherited controllers are established research directions, yet a narrower question remains: can a newborn artificial agent exhibit measurable biparental heredity before learning, and can that dependence be isolated causally rather than inferred only from parent-offspring resemblance? We introduce Machine Zygote, a computational germline-soma architecture designed to test this question. Two parental germlines are independently mutated and recombined into a zygote that parameterizes development of an initially generic eight-module soma, which is then frozen and evaluated without learning. A preregistered 4 x 4 diallel of 640 offspring shows significant dam and sire dependence for five of six behavioral traits after Holm correction, with parental and interaction components accounting for 36-53 percent of modeled variance across five principal traits. In matched-background interventions (n=60), substituting one parental germline while holding recombination and stochastic background fixed causes phenotype shifts exceeding a same-parent re-mutation control for five of six traits for both parental channels. Recombination also yields excess transgressive offspring for speed and gait frequency. A preregistered developmental-dependence hypothesis is not supported: a quasistatic no-dynamics ablation preserves the mean phenotype distribution while altering parental variance structure. Thus the study supports causal biparental pre-learning heredity in this simulation, but not the stronger claim that recurrent developmental dynamics are necessary. It does not establish physical heredity, biological genetics, or autonomous evolution. The contribution is an intervention-centered framework and reproducible benchmark for separating heredity, development, stochastic variation, and post-birth learning.

Capabilities relevant to Physical AI can arise from materially different formation histories, yet existing taxonomies organized by morphology, architecture, learning algorithm, task, or domain do not directly answer what gives rise to a capability. We define a capability-formation source as a factor materially contributing to capability formation, distinct from components or construction steps. We identify seven non-exclusive sources: Recorded-Experience (RE), Predictive-Modeling (PM), Evaluative-Interaction (EI), Surrogate-Environment (SE), Mechanism-Grounded (MG), Embodied-Coupling (EC), and Evolution-Driven (ED) Formation. Using reconstructive induction with theoretical saturation, we traced a research matrix to primary studies, deduplicated the literature, set coding rules, and conducted three rounds of maximum-difference and negative-case sampling. Challenges included curriculum and self-supervised learning, active inference, open-ended and developmental learning, planning and search, neuro-symbolic architectures, digital twins, generative physical world models, and morphology-control co-design. Within the scope and criteria fixed as of September 4, 2026, all 49 evidence records were explainable by the seven sources individually or in combination. No R1-R3 challenge produced an irreducible eighth source, and R3 required no new core definition or substantive boundary rule. We therefore claim theoretical saturation within the stated scope, not logical completeness or exhaustive future coverage. The framework distinguishes similarity in observed capability from similarity in how it was formed, supporting analysis of explanation, transfer, replication, dependencies, governance evidence, and geoeconomic foundations.

Sea-ice stage of development (SoD) describes the age and associated thickness of sea ice and provides important information for navigation, and operational ice monitoring. SoD labels are obtained from operational ice charts, where trained analysts interpret satellite observations and assign standardized stage codes to regions with similar ice conditions. These codes often represent ranges of compatible ice thicknesses rather than exact physical values. Deep-learning methods can automate SoD mapping and commonly adopt operational ice charts as reference labels for training. These annotations are not exact, however; this is because chart interpretation relies on analyst judgement and on the observations available at the time, so different ice services may assign different SoD labels to the same conditions. We term this variation across independently produced expert annotations multi-annotator label uncertainty; collapsing the annotations into a single deterministic target discards this variation. A second source of uncertainty originates in the learned model itself. In this paper, we quantify both sources: annotation uncertainty from disagreement among independent ice-service charts and model uncertainty from the learned predictive models. We then evaluate their relationship by testing whether model uncertainty is higher where ice services disagree. We observe that supervision incorporating information from multiple annotators can improve this correspondence, with soft supervision achieving the highest overall correlation of 0.256. The relationship becomes substantially stronger near the ice edge, where model predictive uncertainty closely tracks multi-annotator disagreement, reaching a correlation of 0.704 within 0--10 km. Among the uncertainty-estimation approaches, Monte Carlo dropout provides the best-calibrated confidence estimates, with an expected calibration error of 0.050.

Noisy annotations pose a significant challenge for supervised deep learning, as neural networks rely on large-scale, high-quality labeled data whose corruption can severely impair model performance. Although robustness to label noise has been extensively studied for classification tasks, it remains relatively underexplored in Pose Estimation (PE). This limitation becomes critical in clinical contexts, including neonatology, where PE of preterm infants is used to support the assessment of spontaneous motility, a key indicator of neurodevelopmental trajectories. In such settings, infants' images labeling is further hindered by visual challenges (e.g., keypoint self-occlusions, caregiver interference), making the annotation process inherently susceptible to errors. To tackle noisy annotations in PE, we introduce REliable keypoint selection via Memory of traINing Dynamics (REMIND), a clustering-based keypoint-selection strategy that exploits keypoint-wise training dynamics to identify noisy labels without assuming any prior knowledge of the noise distribution, thus enabling noise-free model training. When evaluated on the proprietary NeoPose dataset, comprising 46 videos of 46 preterm infants recorded in real clinical settings, REMIND correctly identifies noisy annotations across multiple corruption scenarios, achieving up to 93% Area Under the Curve (AUC) with three different PE architectures used in the relevant literature. To our knowledge, this is the first study to explicitly address label noise in preterm infants' PE, paving the way for the design of trustworthy learning-based algorithms for infants'monitoring support when data quality cannot be guaranteed.

Across the full Pythia suite (160M-12B, eight checkpoints, four task families), a linear probe can read a target variable from the residual stream as early as step 1,000 at every scale -- yet steering along that same reading direction remains null-equivalent in 43 of 48 model-checkpoint cells. Internal readability systematically outruns causal efficacy, and the lag does not shrink with scale. We call this structure lagged coupling and decompose it into three dissociable tracks: (i) internal readability, saturated (AUROC >= 0.990) from the first checkpoint everywhere; (ii) behavioral readability, which develops gradually and progressively later at larger scales (12B reaches 0.909 only at the final checkpoint); (iii) causal efficacy, almost always null-equivalent, occasionally counterproductive early, with one isolated positive pulse (12B, step 8,000, z = +2.49) our grid cannot resolve. The ordering is dominantly read-before-write (11/11 units, no inversion). Representation headroom along the probe direction grows up to 57x with training and scale while causal write-in stays below 0.11% of headroom -- the variable is increasingly written into the representation and increasingly ignored by the readout. Under a fully pre-registered protocol, both single-onset hypotheses resolve INDETERMINATE (scale slope +0.24, 95% CI [-0.60, +0.87]; time vote 3:3) -- a disciplined negative explained by the three-track decomposition. A pre-registered OLMo-2 replication preserves the direction at attenuated magnitude. Our results caution against inferring steerability from probe accuracy and establish a developmental bottleneck: representation formation reliably outpaces causal readout consolidation.

A host of recent studies have evaluated the cognitive and developmental alignment of Foundation Models (FMs). These investigations include evaluations of their correspondence to adult performance across a range of cognitive domains, as well as whether aspects of model training track children's cognitive development. However, using FMs as candidate cognitive models poses significant methodological and conceptual challenges. A key question underlies this effort: under what conditions does behavioral alignment justify treating FMs as explanatory models of cognition? In this paper, we articulate a four-stage inferential framework for evaluating FMs as cognitive and developmental models: adapting human experimental tasks to model-compatible formats, specifying linking hypotheses that map model outputs to human measures, evaluating behavioral correspondence, and comparing across candidate models or manipulations. We clarify the role of linking hypotheses in mapping model outputs to human behavioral measures, identify challenges that constrain alignment claims, and propose principles for theory-driven and comparative evaluation. Throughout, we argue that behavioral fit alone is insufficient. Alignment becomes scientifically meaningful only when embedded within explicit theoretical commitments, theory-diagnostic tasks, and systematic contrastive evaluation across candidate models.

Transformers have had a profound impact on the world of language processing and computer vision. As efforts to answer the million-dollar question of ``How does a Transformer learn?" have been increasing, existing interpretability studies primarily analyze representations at isolated layers or the network as a whole, while the developmental evolution of individual representations and its manifolds across transformer layers remains underexplored. With this work, we aim at providing a comprehensive analysis of the evolution of representations as the representation point cloud transforms across the layers; thereby attempting to isolate layers or establish a trend which comes closer to justifying how and when raw input representations evolve into task-relevant feature representations. Thus, Transformer Geometry Observatory-TGO-IV introduces a topological framework for analysing the evolution of Transformer representations through the lens of Persistent Homology. Rather than studying local geometric properties alone, TGO-IV constructs Vietoris--Rips simplicial complexes from token-level representation point clouds and investigates the evolution of their persistent topological signatures across Transformer layers. The proposed framework comprises complementary topological observatories including Persistence Diagrams, Barcode Diagrams, Betti Curves, Persistence Landscapes, Bottleneck Distance, and Wasserstein Distance, enabling a comprehensive analysis of how the global topology of representation point clouds develops throughout the forward pass.

This paper addresses how to enable a humanoid robot to learn motion policies based on developmental principles and combine policies to create more sophisticated and useful behaviors. Specifically, we present an approach to (1) learning a whole-body reaching and grasping policy and (2) combining it and a standing-up and walking policy to compose a more complex policy of manipulation and locomotion: grasping, standing up, and walking. In (1), our method draws inspiration from harmonic analysis and adopts cubic harmonics as weights to represent the hand-object spatial relationship via spatial convolution. Utilizing an intra-episode finger joint decoupling curriculum based on developmental principles, a robot can autonomously learn a generalizable grasping policy without relying on external datasets or pretrained models. In (2), our method combines the grasping policy with a separately learned getting-up policy by providing both policies with their respective observation vectors and using hand-object interaction scores to determine when each policy should control which robot joints. Our results show a 93% zero-shot success rate for grasping unseen objects and a 96-100% success rate for standing up while holding the object. Our work also demonstrates that combining different policies is only effective if each policy learning happens on the same whole humanoid body even if a policy (such as for locomotion) does not seem to need all the body parts (such as fingers).

Contemporary machine learning struggles to learn continually, reuse prior knowledge, and expose a comprehensible internal structure. A recently proposed developmental, gradient-free learning framework addresses these limitations by learning a discrete, topological model of its inputs through local variation and selection, yielding an inherent continual-learning guarantee: new observations refine existing structure without overwriting past knowledge, and without replay buffers or predefined task boundaries. Its extension to visual inputs demonstrated this principle on shape recognition, but relied on a feature representation of limited expressivity that capped recognition accuracy. We introduce a new visual feature representation that encodes shape structure across multiple scales, capturing edge and contour features together with their spatial relations, and integrate it with the network-refinement learning process; we further improve the learning dynamics and the read-out used to predict from the learned model. The study targets two-dimensional shape, with class-incremental MNIST as a controlled, interpretable benchmark in which continual-learning behavior can be measured directly. Our approach substantially increases accuracy over the prior representation, matching or exceeding replay- and regularisation-based baselines at comparable storage while storing no past data, and preserves the framework's defining behavior: earlier-learned classes are retained as new ones are introduced, with no destructive adaptation, and the learned representations remain human-interpretable. What separates the methods is retention: the baselines surrender most of a just-trained class within its own cycle and relearn it afterwards, which ours does not. The significance lies in the manner of learning. The system integrates information one sample at a time while provably preserving its responses to...

Can evolutionary dynamics characteristic of biological development arise without a designer-specified fitness function? We present Genesis, a platform in which agents inhabit a Gray-Scott reaction-diffusion substrate and evolve under physical constraints alone. Three successive experimental cycles, each testing one falsifiable hypothesis, show: (1) constraint-driven selection sustains evolutionary activity after complete fitness removal but reaches a hard phenotypic complexity ceiling; (2) agent-mediated niche construction via chemical secretion is real but causally insufficient to break that ceiling; and (3) replacing the fixed-alphabet genome with a Compositional Pattern Producing Network (CPPN) indirect encoding, protected by NEAT-style speciation, produces the first evidence of progressive structural complexification in a fitness-free system. Null results are treated as precise, informative answers rather than failures, yielding reusable diagnostic tools and a sham-control protocol applicable to any open-ended evolution evaluation pipeline.

We study a society of agents belonging to a number of occupational or cultural groups that form opinions about others' situation in the same or different group. Opinions develop either by observation within own group or by directly interacting with members of other groups, therefore by word of mouth (WoM). Additionally, global mass media (MM) may be available that inform indirectly about the situation of the various groups. The sociocultural interplay of these processes and the degrees of relative exposure to each of the sources has diversified effects on final opinion and social attitude formation. In large and complex societies and groups where not everyone can physically interact by WoM with everyone about everything, these processes show potential for mass control and social automation engineering. Our model can also represent and be generally informative about segmented societies that consist of groups with different occupational and cultural characteristics and it can offer insights into social issues such as the generation gap, social cleavages and so on.

Growing Neural Cellular Automata (GNCA) develop complex morphologies from a single seed cell through shared local rules, yet the internal dynamics of this process remain poorly understood. To investigate how GNCA grows, the full developmental trajectory of trained GNCA models was traced. The trajectory of cell state development revealed that morphological convergence often proceeds non-monotonically through transient intermediate configurations. In addition, channel-wise analysis showed that the hidden channels self-organize into modular groups in parallel with the visible form. Furthermore, geometric analysis of the cell state space indicated that cell states diversify within a low-dimensional, smooth manifold. To examine cell development in more detail, community detection on an $ε$-neighbour network of cells was conducted. This analysis successfully extracted discrete cell types from this continuous space, and identified transient cell-type communities during early development and stable, finer-grained types corresponding to spatially coherent regions of the mature morphology. The temporal coordination of these phenomena across multiple independent measures indicates that the developmental process of GNCA is a reorganization of transient states rather than incremental refinement.

Cross-modal learning, i.e., learning to predict one modality from another, is a fundamental mechanism for self-supervision via leveraging multimodality. Many practical applications, e.g., deploying a household robot, involve devices that are equipped with a rich set of sensors that enable multimodal sensing in their test environment. This presents an opportunity to apply cross-modal learning to the multimodal data sensed by these devices to learn representations. Findings in developmental psychology also suggest that biological agents leverage it to build an effective representation of their surroundings. To study this, we propose a controlled setup, where we restrict a user device to just a given test environment. It results in a specialization setup where we attempt to develop a performant model for this specific test environment. Under this setup, we develop Test-Space Training (TST), which performs multimodal data collection in the test environment and performs self-supervised pre-training on it. We evaluate these models on various downstream tasks in the same environment. Under this setup, we find various interesting insights, such as collecting rich multimodal data only from the test environment and leveraging cross-modal learning, we can achieve competitive results with generalist models (e.g., DINOv2 and CLIP) pre-trained on large-scale internet datasets. This enables an alternative scenario where the need for external Internet-scale datasets for pre-training models is reduced. We also present a set of analyses and ablations that raise intriguing points on substituting data with (multi)modality, and how varying pre-training data enables a tradeoff between a model's abilities to specialise to a test environment, and generalize to held-out spaces.

Spatial and Single-cell transcriptomics are transformative in deciphering cellular dynamics. As the fundamental paradigm for reconstructing cell developmental paths, trajectory inference (TI) is critical. However, existing methods require extensive manual intervention and proficiency in heterogeneous tools, posing a significant barrier to efficient TI analysis. To bridge this gap, we propose SpaCellAgent, an autonomous large language model (LLM) multi-agent framework that automates end-to-end spatiotemporal analysis and narrative generation. SpaCellAgent utilizes a multi-agent architecture for strategic workflow planning, a dynamic tool-orchestration engine for adaptive algorithm selection, and a self-evolution module that iteratively refines performance through feedback. We evaluate SpaCellAgent on six heterogeneous datasets encompassing complex temporal developmental trajectories, diverse sequencing platforms, and spatially-resolved tissue architectures. SpaCellAgent consistently demonstrates over 40% improvement in analytical efficiency while maintaining expert-aligned performance. By converting natural language specifications into optimized analytical workflows and fully automating the pipeline, SpaCellAgent democratizes advanced spatiotemporal modeling and establishes a scalable, agent-driven paradigm for computational biology. The code and materials are available at https://github.com/LittleXH-shw/SpaCellAgent.

How much does a vocalization change over the course of development? We propose trajectory variance, a per-vocalization plasticity score that answers this question without type labels. A displacement model learns to predict age-conditioned shifts in autoencoder latent space; the variance of its predictions across target ages quantifies how much each vocalization would change if produced at different developmental stages. Evaluated on three zebra finches (183K-274K vocalizations, 40-101 days post-hatch), trajectory variance separates learned song syllables from innate calls (Cohen's d = 0.29-0.57, AUC = 0.58-0.67, after controlling for duration), while no nonparametric baseline achieves consistent separation. Trajectory variance also correlates with spectral flatness across all three birds (r = -0.48 to -0.75): more plastic vocalizations tend to have more tonal, structured spectra.

Recent work suggests that Large Language Models (LLMs) are sensitive to the belief states of agents described by text, as measured by the false belief task (FBT), yet persistent concerns of construct validity remain. We adopt a developmental perspective, tracing the pattern of mental state reasoning behavior -- and likely preconditions for this behavior -- across multiple training stages in the Olmo2 and Pythia language model suites. We find that above-chance FBT performance depends both on model size and sufficient training volume, emerges relatively late in pretraining, and is most improved by post-training interventions (SFT, DPO) in the condition most diagnostic of mentalizing (False Belief, Implicit). However, FBT performance is fragile: consistent with past work, the use of non-factive verbs (e.g., thinks) increases false belief attributions even in the True Belief condition. To contextualize these findings, we track the emergence of situation modeling: the ability to report on basic factual properties of a described scene. Situation modeling accuracy generally precedes and exceeds FBT accuracy, yet situational representations also prove surprisingly incoherent in certain respects: when asked about the knowledge states of the Antagonist agent -- who always knows the item's true location -- Olmo2 13b is consistently influenced both by the Target agent's knowledge state and the presence of non-factive verbs. Together, these results suggest that larger, sufficiently trained models build partially coherent situation models in a developmentally appropriate sequence, yet display surprising fragility -- highlighting the value of developmental and stress-testing approaches for evaluating LLM capabilities.

Obesity is a global health crisis associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. This study employed single-cell RNA sequencing to reconstruct the developmental trajectory of human adipocytes from adipose tissue samples. Our analysis identified 15 transcriptionally distinct cell clusters, including 7 transitional states, revealing the dynamic process of adipocyte differentiation. We detected 16 functionally active signaling pathways mediating cellular communication between adipocytes and their progenitors. Among these, insulin-like growth factor (IGF) and fibroblast growth factor (FGF) pathways emerged as the most prominent networks, showing consistent activity across differentiation stages (p<0.05). The study revealed depot-specific differences, with visceral adipocytes undergoing additional extracellular matrix remodeling absent in subcutaneous differentiation. Spatial analysis further showed that IGF signaling was particularly active in perivascular niches, while FGF activity dominated in mature adipocyte zones. These results provide the first comprehensive map of human adipocyte development, highlighting IGF and FGF pathways as potential therapeutic targets. The identified signaling networks offer new insights for developing interventions to promote healthy adipose expansion or inhibit pathological fat accumulation. This work advances our fundamental understanding of adipose tissue biology while providing clinically relevant data for metabolic disorder treatments.

In this study, we use a developmental approach to investigate the statistical learning and mental representation of neural language models (NLM). A series of Generative Transformer models are trained on a synthetic grammar. The model states are saved at multiple stages in the course of training. Through analyzing how the internal representations of these models change in the developmental path, we found that NLMs acquire the most abstract global statistical knowledge at the beginning of learning and later acquire the relatively local statistical dependencies. This learning path contains many over-generalizations from the very beginning and these over-generalizations are gradually constrained in the later stage of learning. Based on this observation, we propose a new framework to explain the statistical learning and language cognition of NLMs.

AI companions powered by large language models increasingly interact with cognition-developing users, including children and adolescents, creating risks that may accumulate over time. Existing safety evaluations largely rely on single-turn or short-session tests, which cannot capture risks that emerge only through prolonged interaction. To address this gap, we propose TSJ (Theater-Stage-Judge), a longitudinal framework combining persona-driven user simulation, dynamic psychological-state updating and retrospective evaluation. We evaluate six mainstream models across four developmental stages, twenty-four risk dimensions and three psychological-vulnerability personas, covering 12,960 simulated person-day interactions. TSJ shows that short-horizon testing systematically underestimates developmental risks, for which TSJ yields a stable risk estimate only after 140 turns within prolonged simulated relationships. Applying TSJ further identifies early childhood and emerging adulthood as the most vulnerable stages, with cognitive trust and emotional dependency as the weakest domains. TSJ provides a scalable methodology for longitudinal cognitive developmental risk evaluation in AI companion systems.

Knowledge distillation transfers a teacher's competence to a small student but is brittle in the small-student regime: forcing the student to imitate logits from a much larger teacher concentrates it on the teacher's sharpest modes, hurting generalization on benchmark families beyond the training corpus. Reinforcement learning (RL) avoids logit imitation by training on the student's own rollouts. However, on questions where every rollout fails, yielding zero advantage and being silently discarded, injecting a stronger teacher's response into the policy gradient breaks the on-policy assumption and induces drift. We introduce Zone of Proximal Policy Optimization (ZPPO), inspired by Vygotsky's zone of proximal development, which keeps the teacher inside the prompt rather than the policy gradient. On hard questions, ZPPO constructs two reformulated prompts. A Binary Candidate-included Question (BCQ) pairs one correct teacher response with one incorrect student response as anonymized candidates the student must reason between. A Negative Candidate-included Question (NCQ) aggregates the student's wrong rollouts into a single prompt to surface their shared failure modes. A prompt replay buffer recirculates each hard question until it either graduates (the student's mean rollout accuracy on it reaches half or more) or is FIFO-evicted under finite capacity, amplifying BCQ and NCQ inside the student's current zone of proximal development. On the Qwen3.5 family at four student scales (0.8B-9B) with a 27B teacher, post-trained as vision-language models and evaluated on a 31-benchmark suite (16 VLM, 10 LLM, 5 Video), ZPPO outperforms off/on-policy distillation and GRPO, with the largest gains at the smallest scale.

Large language models provide a tractable system for asking how intelligence itself emerges, rather than only how LLMs can be engineered. Although progress is usually attributed to scale, data and architecture, we show that parameter initialization is a gene-like determinant of training and, in particular, of model capacity. Reducing the initialization scale consistently improves pretraining, with the largest gains on reasoning-demanding tasks. We identify two widely used empirical settings that restrain the advantage of small initialization, and show how relaxing them restores favorable scaling. We further uncover a critical initialization that balances the reasoning and training. Mechanistically, small initialization drives a distinct developmental trajectory: parameters first condense into low-complexity structures and later expand into richer representations, giving concrete form to the idea that compression is intelligence. Token-level analyses show that the gains concentrate on non-trivial, context-constrained predictions rather than all tokens uniformly. These results motivate a simple $γ$-initialization rule: expose initialization rage as an explicit knob and use small initialization by default, an almost cost-free intervention that improves pretraining and strengthens reasoning across model scales.

We track the developmental trajectory of attention-head circuit formation across three 1B-class language models spanning two architecture families (dense transformer, mixture-of-experts) and two pretraining corpora (The Pile, DCLM): Pythia 1B, OLMo 1B-0724-hf, and OLMoE 1B-7B-0924. At each of 10 log-spaced revisions per model -- 30 mechanistic-interpretability runs in total -- we apply a participation-ratio (PR) spectral signal and an all-head capability-specific selectivity screen to track induction, previous-token, and BOS-attractor heads as they emerge. Five findings. (F1) Layers 0 and 1 produce zero BOS-classified heads at every revision in every model: the L0/L1 zero-BOS floor is an architectural property, not a learned outcome. (F2) The whole-model BOS-attractor fraction follows three distinct emergence shapes -- a gradual ramp in Pythia 1B, a sharp phase transition in OLMo 1B (7% to 70% between adjacent checkpoints), and a gradual ramp in OLMoE 1B-7B. (F3) In DCLM models, induction-circuit formation precedes BOS-attractor formation by 10-20x in tokens; capability-circuit formation and attention-sink formation are two transitions, not one. (F4) The capability-specific screen converges to the final induction circuit within 0.3-2% of total training tokens -- circuit identification does not require the final model. (F5) For every final-checkpoint induction head sampled across all three models, per-head PR is elevated at or before the first revision at which that head crosses its capability-selectivity threshold. The results refine the induction-phase-transition framing: in 1B-class models trained on DCLM, the induction transition and the attention-sink transition are separated by an order of magnitude in tokens and have qualitatively different shapes.

Predicting how a cell will change its transcriptional state under a developmental signal or a genetic perturbation is the computational core of in-silico biology and the AI Virtual Cell program. Existing approaches either fit static control-to-treated maps that discard time, or solve multi-step ODE / Schrödinger-bridge problems on each dataset independently. We introduce Chreode, a one-step cell world model that predicts action-conditioned cell-state transitions through a structured residual transition operator. It shifts distributional evolution from inference time to training time, enabling single-pass generation while preserving a Waddington-inspired decomposition into downhill landscape flow, rotational in-tangent dynamics, and stochastic spread. The model is pretrained with a shared scVI encoder and a DiT-based dynamics backbone on a 2.4M-cell mouse embryonic atlas spanning 7 datasets. As a fine-tuning initialization, Chreode improves per-target Sinkhorn distance on Weinreb hematopoiesis and Veres islet differentiation over matched scratch models, PI-SDE, and PRESCIENT. As a transferable gene-state embedding for GEARS, the pretrained dynamics representation reduces shared-vocabulary DE20 mean squared error on Norman Perturb-seq from 0.2121 to 0.1858, a 12.4% relative improvement, without changing the GEARS training procedure. We interpret this transfer to perturbation prediction as evidence that pretrained developmental-trajectory dynamics encode differentiation primitives transferable to CRISPR-induced state shifts, since both involve cell-state transitions in a shared latent geometry. The pretrained backbone additionally produces zero-shot clonal fate scores on Weinreb that are competitive with strong dynamic-OT baselines.

We present a three-step recipe for identifying attention-head circuits in pretrained transformers. A per-head spectral signal -- the time-integrated participation ratio of each head's attention output -- ranks heads doing sustained content-dependent computation without labels or attribution gradients. A task-pattern screen filters this general indicator into a task-specific candidate circuit, and group ablation against a matched-random control completes the causal claim. We validate across an 8x parameter range (51M to 1B-active / 7B-total), two architecture families (dense, mixture-of-experts), and four pretraining pipelines. The recipe ports: a 2-6 head induction circuit is causally necessary in every model tested, with a 94-100% drop in synthetic-induction top-1 after ablation. The spectral signal is predictive without supervision: on six independent seeds of a 51M-parameter probe model, the same computation identifies the seed-specific circuit on each seed. The fraction of heads doing identifiable specialized computation is conserved at 17-19% across the Pythia family (124M to 410M), while specific induction circuits stay 3-11 heads -- sublinear in total head count. This paper is the methodology anchor of a three-paper program; companion papers extend the recipe to developmental trajectories during pretraining and to composed-task circuits where pattern selectivity decouples from task-causal structure.

Children acquire language grounding with remarkable robustness from limited visuo-linguistic input in ways that surpass today's best large multimodal models. Recent research suggests current vision-language models (VLMs) trained on curated web data fail to generalize to the sparse, weakly-aligned egocentric streams produced by wearable devices, embodied agents, and infant head-cams -- and no fixed evaluation pipeline exists for measuring progress on this regime. We train VLMs on datasets with varying degrees of semantic alignment between visual and linguistic inputs, including naturalistic infant and adult egocentric videos, and evaluate them with a comprehensive suite spanning multimodal language grounding and unimodal vision and language tasks. At the core of this suite is Machine-DevBench, a corpus-grounded benchmark of lexical and grammatical competence, automatically generated from the model's training vocabulary across logarithmic frequency bins to eliminate the train/eval mismatch and low statistical power of prior developmental benchmarks. Our results show that current VLM paradigms hinge on the tight semantic alignment of curated data and fail to exploit the weakly-aligned signal that dominates naturalistic egocentric input -- the very regime in which humans thrive. To motivate progress, we introduce the EgoBabyVLM Challenge to drive the development of models capable of grounded language learning from the kind of naturalistic data that human infants experience.

From subcellular structures to entire organisms, many natural systems generate complex organisation through self-organisation: local interactions that collectively give rise to global structure without any blueprint of the outcome. Yet a significant portion of the information driving such processes is not produced by self-organisation itself, instead, it is often offloaded to initial conditions of the system. Biological development is a prime example, where maternal pre-patterns encode positional and symmetry-breaking information that scaffolds the self-organising process. From maternal morphogen gradients in early embryogenesis to tissue-level morphogenetic pre-patterns guiding organ formation, this transfer of information to initial conditions, analogous to a memory-compute trade-off in computational systems, is a fundamental part of developmental processes. In this work, we study this offloading phenomenon by introducing a model that jointly learns both the self-organisation rules and the pre-patterns, allowing their interplay to be varied and measured under controlled conditions: a Neural Cellular Automaton (NCA) paired with a learned coordinate-based pattern generator (SIREN), both trained simultaneously to generate a set of patterns. We provide information-theoretic analyses of how information is distributed between pre-patterns and the self-organising process, and show that jointly learning both components yields improvements in robustness, encoding capacity, and symmetry breaking over purely self-organising alternatives. Our analysis further suggests that effective pre-patterns do not simply approximate their targets; rather, they bias the developmental dynamics in ways that facilitate convergence, pointing to a non-trivial relationship between the structure of initial conditions and the dynamics of self-organisation.

Automated ASD screening tools remain limited by single-architecture evaluations, axis-restricted assessment, and near-exclusive focus on adult cohorts, obscuring age-specific diagnostic patterns critical for early intervention. We introduce ASD-Bench, a systematic tabular benchmark evaluating ML, deep learning, and foundation model configurations across three age cohorts (children 1-11 yr, adolescents 12-16 yr, adults 17-64 yr) on four axes: predictive performance, calibration, interpretability, and adversarial robustness. Applied to a curated v3 dataset of 4,068 AQ-10 records, our benchmark spans classical models (XGBoost, AdaBoost, Random Forest, Logistic Regression), neural networks (MLP), deep tabular transformers (TabNet, TabTransformer, FT-Transformer), and TabPFN v2. We introduce the Heuristic Aggregate Penalty (HAP): a cost-sensitive metric penalising false negatives more heavily and incorporating cross-validation variance for deployment stability. Adult classification yields high performance (10/17 models achieve perfect F1 and AUC), while adolescents present a harder task (F1 ceiling 0.837 vs. 0.915 for children). Feature hierarchies shift across cohorts: A9 (social motivation) dominates for children, A5 (pattern recognition) leads for adolescents, and adults exhibit a flatter importance profile consistent with developmental social masking. Accuracy and calibration are dissociated: AdaBoost achieves F1=1.000 on adults with ECE=0.302, confirming single-metric evaluation is insufficient for clinical AI. Cohort-specific deployment recommendations are provided. All findings should be interpreted as proof-of-concept evidence on questionnaire-derived labels rather than clinically validated diagnostic performance.

The Metacognitive Probe is an exploratory five-task, 15-slot diagnostic that decomposes an LLM's confidence behaviour into five behaviourally-distinct dimensions: confidence calibration (T1-CC), epistemic vigilance (T2-EV), knowledge boundary (T3-KB), calibration range (T4-CR), and reasoning-chain validation (T5-RCV). It is evaluated on N=8 frontier models and N=69 humans. The instrument is motivated by Flavell (1979) and Nelson and Narens (1990) but operates on observable confidence-correctness alignment; it is not a validated cross-species metacognition scale, and the pre-specified human developmental hypothesis was falsified. Composite benchmarks (MMLU, BIG-Bench, HELM, GPQA) ask whether a model produces a correct response. They are silent on whether the model knows when its response is wrong. A model can score 80 on a composite calibration benchmark and still be wildly overconfident in narrow pockets the aggregate cannot surface. The Metacognitive Probe surfaces those pockets. Our headline is a 47-point within-model dissociation in Gemini 2.5 Flash: panel-best within-task calibration (T1-CC = 88; Spearman rho = +0.551, 95% CI [+0.14, +0.80], p = 0.005) and panel-worst cross-task difficulty prediction (T4-CR = 41; sigma_conf = 1.4 across twelve factoids).

This paper is concerned with what intermediate syntactic categories children acquire during first language development, and in what order. Maturational theories make different predictions. Bottom-up accounts (GROWING) propose that lexical and inflectional structure emerges first, while inward accounts (INWARD) predict early access to discourse-related categories. We computationally operationalise these hypotheses of staged syntactic emergence using statistical grammar induction, asking what each proposed ordering makes learnable when input and learning algorithm are held constant. Our framework makes category acquisition explicit and allows us to explore how different maturational orderings shape the structure that can be learned under identical conditions. Based on this operationalisation, the GROWING account significantly outperforms the INWARD account across three evaluation metrics.

Against the backdrop of rapid advances in artificial intelligence, legal argument mining has emerged as an important research area linking legal texts with intelligent analysis, carrying significant theoretical and practical implications. Existing studies have primarily developed along three dimensions: data, technology, and theory. At the data level, raw legal texts and annotated corpora constitute the foundational resources. At the technological level, research paradigms have evolved from rule-based systems and traditional machine learning to large language models (LLMs). At the theoretical level, argumentation theory and legal dogmatics provide important references for modeling argumentation structures. However, despite ongoing progress, the overall development of legal argument mining remains relatively slow. Building on a systematic review of existing research, this study conducts an in-depth analysis and finds that this is due not only to data scarcity or technical limitations, but more fundamentally to the lack of a structured representational approach that reconciles theoretical expressiveness with computational feasibility. Specifically, this challenge manifests in dilemmas in data standardization, obstacles to effective modeling, and limitations in domain adaptation. In response, the study proposes several key directions for future research. It aims to provide a reframing of key problems and a pathway for future development in legal argument mining, while leaving specific models and implementation schemes for further investigation.

Motion retargeting from humans to human-like artificial agents is becoming increasingly important as humanoid robots grow more capable. However, most existing approaches focus only on reproducing kinematics and ignore the rich sensorimotor experience associated with human movement. In this work, we present a framework for simulating the multimodal sensorimotor experiences of infants using physical and virtual humanoids. From a single video, our method reconstructs the infant's body configuration by extracting its skeletal structure and estimating the full 3D pose from each frame. Then we map the reconstructed motion onto several developmental platforms: the physical iCub robot and the virtual simulators pyCub, EMFANT and MIMo. Replaying the retargeted motions on these embodiments produces simulated multisensory streams including proprioception (joints and muscles), touch, and vision. For the best-matching embodiment, the retargeting achieves sub-centimeter accuracy and enables a rich multimodal analysis of infant development as well as enhanced automated annotation of behaviors. This framework provides a unique window into the infant's sensorimotor experience, offering new tools for robotics, developmental science, and early detection of neurodevelopmental disorders. The code is available at https://github.com/ctu-vras/motion-retargeting/.

Artificial intelligence (AI) literacy is increasingly recognized as a foundational competency for all university graduates. Yet students' engagement with AI tools often clusters at two extremes: avoidance driven by fear, mistrust, ethical concern, or lack of access, and uncritical reliance that produces fluent output while masking misunderstanding. Existing AI literacy frameworks provide valuable competency definitions, but most offer limited guidance for diagnosing where learners begin and how they progress toward responsible, critical engagement. This paper proposes a five-stage AI Literacy Continuum: 0) Not Yet Engaged, 1) Uncritical Use, 2) Informed Use, 3) Critical Evaluation, and 4) Improvement --that describes developmental orientations toward AI use in higher education. The continuum complements dimensional frameworks by providing educators with a practical diagnostic and instructional pathway aligned with international frameworks, including UNESCO and OECD. We present a design-based implementation case from North Carolina State University, where credit-bearing courses and intensive hands-on workshops engaged more than 330 participants between Fall 2024 and Spring 2026. Because the implementation did not use a validated pre/post instrument or comparison group, we frame the findings as observational and practice-based: participants exhibited behaviors consistent with movement from non-engagement or uncritical use toward informed engagement, while sustained and discipline-embedded experiences produced stronger evidence of critical evaluation and improvement-oriented practice. We discuss curricular pathways, opportunity considerations, assessment strategies, and argue that AI literacy should be understood not as tool adoption alone but as a developmental capacity to understand, evaluate, and responsibly apply AI systems in disciplinary and societal contexts.

Classical robot ethics is often framed around obedience, including Asimov's laws. This framing is insufficient for contemporary AI systems, which are increasingly adaptive, generative, embodied, and embedded in physical, psychological, and social environments. This paper proposes conditional mutualism under governance as a framework for human-AI coexistence: a co-evolutionary relationship in which humans and AI systems develop, specialize, and coordinate under institutional conditions that preserve reciprocity, reversibility, psychological safety, and social legitimacy. We synthesize concepts from computability, machine learning, foundation models, embodied AI, alignment, human-robot interaction, ecological mutualism, coevolution, and polycentric governance. We then formalize coexistence as a multiplex dynamical system across physical, psychological, and social layers, with reciprocal supply-demand coupling, conflict penalties, developmental freedom, and governance regularization. The model gives conditions for existence, uniqueness, and global asymptotic stability of equilibria. We complement the analytical results with deterministic ODE simulations, basin sweeps, sensitivity analyses, governance-regime comparisons, shock tests, and local stability checks. The simulations indicate that governed mutualism reaches a high coexistence index with negligible domination, whereas insufficient or excessive governance can produce domination, weak-benefit lock-in, or suppressed developmental freedom. The results suggest that human-AI coexistence should be designed as a co-evolutionary governance problem rather than as a static obedience problem.

While current deep learning models achieve high performance by learning statistical correlations from vast datasets,which stands in stark contrast to human learning. They lack the flexibility of humans-particularly preverbal infants-to autonomously acquire the underlying structure of the world from limited experience and adapt to novel situations. In this study, we propose an unsupervised representation learning method based on a hierarchical relationship in group operations, rather than statistical independence, aiming to build a computational model of the cognitive development of infants. The proposed model features an integrated architecture that simultaneously performs object segmentation and the extraction of motion laws from dynamic image sequences. By introducing the Homomorphism from algebra as a structural constraint within a neural network, the model structurally separates pixel-level changes into meaningful, decomposed transformation components, such as translation and deformation. Using interaction scenes (chasing and evading tasks) based on developmental science findings, we experimentally demonstrate that the model can segment multiple objects into individual slots without any ground-truth labels. Furthermore, we confirmed that relative movements between objects, such as approaching or receding, are accurately mapped and structured into a one-dimensional additive latent space. These results suggest that by introducing algebraic geometric constraints rather than relying solely on statistical correlation learning, physically interpretable "disentangled representations" can be acquired. This study contributes to the understanding of the process by which infants internalize environmental laws as structures and provides a new perspective for constructing artificial systems with developmental intelligence.

The accurate quantification of brain age from MRI has emerged as an important biomarker of brain health. However, existing approaches are often restricted to narrow age ranges and single-modality MRI data, limiting their capacity to capture the coordinated macro- and microstructural changes that unfold across the human lifespan. To address these limitations, we developed a multi-modal brain age framework to characterize the integrated evolution of brain morphology and white matter organization. Our model adopts a two-stage architecture, where modalities are processed independently and integrated via late fusion in both stages: first to classify each subject into one of six developmental stages, and then to estimate age within the predicted stage. This design enables a unified and lifespan-spanning assessment of brain maturity across diverse developmental periods.

Advancements in artificial intelligence call for a deeper understanding of the fundamental mechanisms underlying deep learning. In this work, we propose a theoretical framework to analyze learning dynamics through the lens of dynamical systems theory. We redefine the notions of linearity and nonlinearity in neural networks by introducing two fundamental transformation units at the neuron level: order-preserving transformations and non-order-preserving transformations. Different transformation modes lead to distinct collective behaviors in weight vector organization, different modes of information extraction, and the emergence of qualitatively different learning phases. Transitions between these phases may occur during training, accounting for key phenomena such as grokking. To further characterize generalization and structural stability, we introduce the concept of attraction basins in both sample and weight spaces. The distribution of neurons with different transformation modes across layers, along with the structural characteristics of the two types of attraction basins, forms a set of core metrics for analyzing the performance of learning models. Hyperparameters such as depth, width, learning rate, and batch size act as control variables for fine-tuning these metrics. Our framework not only sheds light on the intrinsic advantages of deep learning, but also provides a novel perspective for optimizing network architectures and training strategies.

The human brain folds in utero, primarily during late gestation. Shortly after birth, cortical folding patterns are established and remain stable thereafter, making them promising early neurodevelopmental markers. Yet it is unclear whether the representations given by current neuroimaging foundation models capture cortical folding variability. Here, we introduce Champollion, a self-supervised learning framework that learns interpretable local representations of cortical folding from structural MRI. Optimized on representative folding-related tasks, Champollion accurately captures known folding patterns across cortical regions and external datasets. In a comprehensive benchmark, it consistently outperforms neuroimaging and general-purpose foundation models. Furthermore, Champollion reveals richer genetic associations than conventional morphometric descriptors and identifies localized folding signatures associated with incomplete hippocampal inversion, prematurity, and maternal smoking. These results establish cortical folding as a rich and largely untapped source of neurodevelopmental information, and Champollion provides a unified framework for discovering, localizing and interpreting long lasting cortical folding signatures.