Multimodal Classification
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23 papers in the last four weeks, up 360% on the four weeks before. 0.2% of all new papers.
Latest papers 134
In multimodal classification, late-fusion approaches classify concatenated modality-specific features extracted by unimodal neural networks. When modality imbalance is pronounced, various regularization techniques have been proposed to balance the learning process and overcome the inferior performance of late-fusion networks. In contrast, this work demonstrates that multimodal data can be effectively classified without any explicit modality fusion, using deep ensembles of unimodal networks. We systematically compare deep ensembles to late-fusion networks at equal parameter count and show that ensembles consistently outperform state-of-the-art late-fusion methods designed to address modality imbalance. This advantage also holds over intermediate-fusion techniques we evaluated and over hybrid methods that combine unimodal and multimodal predictions. We propose and empirically validate a method for selecting the number of models per modality in an ensemble, avoiding computationally expensive exhaustive search. Under extreme modality imbalance and small ensemble sizes, the heuristic indicates that ensembles of unimodal models trained solely on the stronger modality are preferable; as the ensemble scales up, incorporating models from the weaker modality becomes beneficial. Both predictions align with our empirical findings. To systematically explore the challenges of optimizing multimodal models, we propose a synthetic multimodal framework that allows control over both the number of modalities and their predictive strength; our findings are consistent across synthetic and real-world datasets. Finally, by fitting scaling laws to bimodal datasets, we estimate the asymptotic performance of ensembles.
AI Wizards at EXIST 2026: Hierarchical Soft-Label Learning for Multimodal Sexism Identification in Memes
We present the AI Wizards submission to EXIST 2026 for multimodal sexism identification in memes. The task is composed of three, increasingly harder subtasks. We model them hierarchically as conditional soft-label prediction over empirical annotator distributions. Our system maps fixed Gemini Embedding 2 vision-language representations through a lightweight Gated MLP trained with KL divergence and homoscedastic uncertainty weighting. Our submissions ranked first on Task 2.3 and fourth on Tasks 2.1 and 2.2 on the official Soft-Soft leaderboards. The code is available at https://github.com/NLP-AI-Wizards/EXIST-2026
Triple-Phase Multimodal Knowledge Aggregation Framework for Microbial Keratitis Subtype Diagnosis on Slit-Lamp Photography
Microbial keratitis requires rapid pathogen identification to guide treatment, but culture- and PCR-based diagnostics are slow and resource-intensive. We developed a triple-phase multimodal framework for bacterial-versus-fungal keratitis classification using slit-lamp photographs acquired under blue-light, sclerotic-scatter, and white-light illumination, together with clinical metadata. The model combines cross-modality contrastive learning, modality-specific fine-tuning, and feature-level multimodal ensemble learning for patient-level prediction. We evaluated the framework on a multicenter dataset of 1,645 patients and 17,158 images from India and the United States. The model achieved 85.84% accuracy, 84.46% average F1-score, and 0.885 AUC. Site-specific evaluation showed that pooled results were overly optimistic, whereas resampling- and balance-based re-evaluation provided a more realistic assessment of cross-site generalization. Under all settings, our framework remained the top-performing approach. The code is available at https://github.com/yqwang01/TPMKA and dataset access will be provided subject to University of Michigan data-sharing clearance.
An Automated Multimodal Glaucoma Detection Framework Using ViT and a Stacking-Based Ensemble
Glaucoma is a progressive eye disease that can lead to irreversible vision loss if not detected at an early stage. Conventional diagnostic procedures are often time-consuming and rely heavily on expert interpretation, limiting their scalability for large-scale screening. In this study, glaucoma detection is investigated under two evaluation settings: sample-wise, where individual samples are analyzed independently, and patient-wise, where data from each patient are aggregated for final prediction. An automated multimodal framework is proposed that integrates fundus images with clinical data. Under the sample-wise setting, detection is performed using fundus images and clinical features individually, as well as through their multimodal combination. Under the patient-wise setting, predictions are obtained by aggregating multiple fundus image representations with corresponding clinical information for each patient. Deep visual features are extracted using a Vision Transformer (ViT) architecture and classified using classical machine-learning models, with a stacking-based ensemble of the three best-performing classifiers employed to optimize performance. Experiments conducted on the publicly available PAPILA dataset demonstrate strong diagnostic performance, achieving 97.47% accuracy and a 97.50% F1-score for sample-wise multimodal classification, and 98.97% accuracy and F1-score for subject-wise detection. The proposed framework is further deployed as an end-to-end web-based platform to support automated glaucoma screening and clinical decision support.
Multimodal Fusion for Fine-Grained Classification of Breast Fibroadenoma and Phyllodes Tumors
Breast fibroadenoma (FA) and phyllodes tumor (PT) are fibroepithelial breast lesions with highly overlapping appearances on B-mode ultrasound, making benign and borderline PT prone to being misclassified as FA and complicating preoperative decision-making. Existing computer-aided diagnosis methods commonly rely on single-modal imaging features and insufficiently exploit complementary clinical and textual information. To address this limitation, we construct the FAPT-M Dataset, a pathology-confirmed multimodal dataset comprising 910 patients with strictly reviewed ultrasound images, structured clinical attributes, and ultrasound diagnostic descriptions. Based on this dataset, we propose a clinically guided multimodal framework that integrates DenseNet-based visual encoding, CLIP-inspired text encoding, and lightweight clinical encoding, and further introduces clinical-conditioned adaptive modulation, cross-modal Transformer fusion, and dual-path representation learning to improve feature alignment and multimodal interaction. Under patient-level five-fold cross-validation, the proposed method achieves an accuracy of 77.64%, F1-score of 73.38%, and AUC of 89.74%, outperforming representative CNN-, Transformer-, and vision-language-based baselines. Ablation studies and class-balanced evaluations further confirm the contribution of three-modality fusion and the key architectural components. Overall, this work provides an effective multimodal approach for fine-grained FA-PT classification and establishes a high-quality benchmark for multimodal breast ultrasound analysis.
Multi-modal Rail Crossing Safety Analysis
Given one or more images of a railway crossing, can we leverage visual cues that allow us to robustly estimate how safe it is? Can we improve our ability to do so by introducing structured data (such as official accident reports) about the accident history of that crossing into our models? In this work, we explore how to best answer those questions towards building an AI system that can ingest multi-modal data for railway crossings and provide safety assessment and scores that align with expert opinion and with safety scoring used by the Federal Railroad Administration (FRA). To that end, we propose a proof-of-concept pipeline that delivers on that goal, while at the same time exploring and tackling a number of critical research challenges that pertain to different parts of the pipeline, from data preparation to different learning paradigms that can allow us to realize such a system. Indicatively, our proposed system identifies HIGH-RISK and LOW-RISK crossings with a macro F1 score of 0.757 and estimates FRA-based safety scores with an RMSE of 0.078 and correlation of 0.492 using a routed fine-tuned compact VLM pipeline, while producing qualitative results that align with domain-expert assessment.
Leveraging Multimodality for Real-Time Classification of Transients and Variables found by the Zwicky Transient Facility
Modern time-domain surveys such as the Zwicky Transient Facility (ZTF) generate hundreds of thousands of alerts each night, making real-time decisions for follow-up observations a central challenge in time-domain astronomy. Robust early classification is crucial for making informed decisions, but is hindered by sparse light curves and degeneracies between classes. In this work, we leverage multimodality to substantially improve real-time classification and demonstrate the practicality of our approach by deploying our model on the ZTF alert stream. Building on the Online Ranked Astrophysical CLass Estimator (ORACLE), we introduce the ORACLE-2 models, which combine light curves, metadata, and images for real-time hierarchical classification. Using both real and simulated datasets, we show that incorporating additional modalities consistently improves classification performance. On observations from ZTF's Bright Transient Survey, our best-performing model, ORACLE-2 Omni, achieves a macro F1 score of 0.73 -- an improvement of up to 11% over models using light curves and metadata alone, and up to 40% over light-curve-only models, with the strongest gains realized at early times. To demonstrate applicability to the Legacy Survey of Space and Time, which will increase alert volume by more than an order of magnitude, we train a light curve + metadata variant on the simulated ELAsTiCC dataset. This model achieves a macro F1 score of 0.88, an improvement of up to 13% over the light-curve-only variant, matching the performance of other state-of-the-art models. Finally, we quantify the trade-offs between performance and throughput, identifying regimes where multimodal approaches offer the greatest benefit. These results show that combining multiple modalities improves early-time classification, enabling more effective triage of high-volume alert streams for current and future time-domain surveys.
Residual-Guided Expert Specialization for Incomplete Multimodal Learning
As real-world prediction systems often face missing modalities at inference, incomplete multimodal learning (IML) remains a practical challenge. While prior methods aim to learn representations robust to missing inputs, representations from incomplete modalities inevitably deviate from their full-modality counterparts due to missing evidence. To explicitly leverage these deviations, we propose MARS (Missingness-Aware Residual-guided Specialization), a mixture-of-experts framework that guides expert specialization based on how representations are reshaped by missingness. By contrasting task representations derived from incomplete inputs with their complete counterparts during training, we derive a privileged residual signal that captures this representational gap. The residual signal guides a residual router to assign samples to experts specialized for the corresponding deviation patterns. In parallel, a feature router learns to imitate this routing behavior using only incomplete inputs, enabling deployment without access to full modalities. To mitigate this train-test router gap, we develop a discrepancy-aware noise regularization that adaptively perturbs the residual router's decisions when the feature router deviates, enhancing expert robustness under imperfect imitation. Experiments on multimodal classification (CASIA-SURF, CREMA-D, UPMC Food-101) and segmentation (MCubeS) under missing scenarios show that MARS consistently surpasses baselines while remaining efficient and extensible to diverse backbones and tasks.
Cross-Modal Iteration Distillation for Robust IHD Screening: The IDNet Framework and A New Benchmark
Color Fundus Photography (CFP) offers a low-cost and non-invasive route for ischemic heart disease (IHD) screening, but current studies are limited by scarce public benchmarks and ineffective fusion of retinal images with sparse clinical variables. We propose IDNet, a multimodal framework with a Cross-Modal Distillation Aggregator (CDA) that uses learnable queries to sequentially integrate left-eye, right-eye, and clinical features, mitigating the imbalance between high-dimensional visual features and low-dimensional tabular inputs. We also construct a reproducible UK Biobank benchmark with open-source curation and quality-control pipelines, yielding 50,410 images from 25,205 subjects. On this benchmark, IDNet outperforms image-only, clinical-only, and several multimodal baselines, and CDA consistently improves multiple visual encoders as a plug-in fusion module.
Traffic-CBM: A Structurally Interpretable Multimodal Framework for Encrypted Traffic Classification
Encrypted traffic classification has achieved strong performance, but its decision process remains difficult to interpret. Existing methods usually combine flow statistics, packet sequences, and byte-level representations into opaque latent features, making it unclear which type of evidence actually drives the prediction. In this paper, we propose Traffic-CBM, a structurally interpretable multimodal framework for encrypted traffic classification. Instead of directly fusing heterogeneous traffic signals into a black-box representation, Traffic-CBM organizes them into a unified hierarchical concept space. These concepts are not manually annotated semantic attributes; rather, they are scalar evidence summaries constrained by predefined traffic evidence groups. More specifically, grouped flow statistics are mapped to statistical concepts, dedicated temporal encoders learn temporal concepts from disjoint feature subspaces, and byte-level evidence is further organized into packet-level and cross-packet concepts. This design turns heterogeneous traffic evidence into an explicit concept representation and makes different levels of traffic evidence easier to analyze. We evaluate Traffic-CBM on multiple encrypted traffic benchmarks. Results show that it achieves competitive and balanced classification performance while providing a clearer structural interpretation interface than conventional end-to-end fusion models. Further analyses suggest that the learned concept space is actively used in the prediction process and provides a clearer structural explanation of multimodal traffic evidence.
AMR: Adaptive Modality Routing for Multimodal Polyglot Speaker Identification
Multimodal speaker identification systems face two key challenges in real-world deployment: missing modalities and language mismatch between training and testing conditions. In practical scenarios, background multi-speaker conversations, ambient noise, and overlapping speech further degrade identification accuracy. To address these challenges, we propose a multimodal polyglot speaker identification system for the POLY-SIM 2026 Grand Challenge. The system is fundamentally built upon Adaptive Modality Routing(AMR), a modality fusion module that dynamically assesses per-sample input quality and integrates modality information. Specifically, AMR employs two modality adapters to process the embeddings extracted from a linguistically robust audio encoder(W2V-BERT 2.0) and a large-scale pretrained face encoder(IResNet-18), producing modality-adapted embeddings. Based on these adapted embeddings, a trainable router estimates dynamic modality weights, which are subsequently applied to aggregate the modality-specific logits for the final prediction. To optimize this routing mechanism, we adopt a modality-aware training strategy that constructs four types of sample pairs to simulate diverse input conditions, with KL divergence serving as explicit supervision for weight assignment. Experimental results on the POLY-SIM 2026 evaluation set show that the proposed system achieves identification accuracy of 99.93%(English multimodal, P3), 100.00%(Urdu multimodal, P5), 97.50%(English audio-only, P4), and 98.83%(Urdu audio-only, P6). The average accuracy across all four protocols is 99.07%, surpassing the Fusion and Orthogonal Projection(FOP) baseline by 32.73%.
Synergistic Dual-Branch Adaptation for Multi-modal Generalized Category Discovery
Generalized Category Discovery (GCD) aims to classify old categories and discover new ones from unlabeled data. Recent multi-modal approaches introduce retrieved or synthesized texts into a dual-branch architecture to provide semantic cues complementary to visual features. However, the cross-modal synergy in existing dual-branch methods remains coarse and incomplete: the two modalities are encoded independently with the bias and noise in the derived text left unaddressed during encoding, and existing mutual learning strategies operate only on global class-level anchors, lacking fine-grained relational supervision. To address these limitations, we propose the Synergistic Dual-Branch Adaptation (SDBA) framework, which serves as a plug-and-play enhancement compatible with existing dual-branch methods such as GET and TextGCD. SDBA comprises two components: the cross-modal synergistic adapter inserts lightweight adapters into both branches and further injects visual information into the text adapter at each encoder layer to enhance text feature learning during encoding; the neighborhood mutual learning module enforces consistent local neighborhood distributions between the two branches via bidirectional KL divergence, providing fine-grained relational supervision for both old and new classes. Extensive experiments on six benchmarks demonstrate state-of-the-art performance, and consistent improvements on different baselines validate the broad scalability of the proposed framework.
Geometry-Aware Superpixel Graph Transformer with Metadata for Skin Lesion Classification
Automated skin cancer classification from dermoscopic images remains challenging due to heterogeneous lesion structure, strong intra-class variability, and subtle visual differences between benign and malignant cases. Existing CNN/ViT pipelines typically rely on global or patch-level features and often combine patient metadata via late fusion, which limits spatially grounded multimodal reasoning. We present a novel region-based graph learning framework that explicitly models lesions as graphs of spatially coherent superpixel regions represented as frozen CNN features. To capture fine-grained lesion arrangements, we encode inter-regional geometry as edge attributes and introduce a dedicated metadata context node connected to all regions, providing structured integration of demographic/clinical variables within the same relational space. Node representations are updated using our edge-aware graph transformer followed by attention-driven propagation, and a final graph-level embedding for benign-malignant classification. Experiments on four public benchmarks demonstrate that explicit region-level relational modeling and graph-native multimodal fusion yield consistent gains over the state-of-the-art. Consequently, we establish a new graph-centric perspective in which CNN features are modeled as relational nodes and improved through contextual integration, yielding more expressive and robust classifications.
Alzheimer's Disease Diagnosis using a Multimodal Approach with 3D MRI and PET
Alzheimer's disease (AD) is an irreversible neurodegenerative disorder and a leading cause of death worldwide. Early diagnosis plays an important part especially at the Mild Cognitive Impairment stage, where timely intervention can help slow its progression before it advances to AD. Neuroimaging data, like Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) scans, can help detect brain changes early by providing structural and functional brain changes related to the disease. Yet, many multimodal models still fuse MRI and PET with static concatenation and apply identical computation to all subjects, which limits robustness to patient/site heterogeneity and can waste computation. To address these limitations, we present the first study of combining 3D convolutional feature extractors with three fusion strategies - concatenation, Gated Multimodal Unit (GMU), and gated self-attention - and a sparsely gated Mixture-of-Experts (MoE) classifier that performs input-adaptive routing, activating only the most informative experts per case. Finally, we utilize Grad-CAM to visualize disease-related regions, ensuring model interpretability. Experiments are performed across three binary classification tasks (NC vs. MCI, MCI vs. AD, and NC vs. AD). Results show that GMU achieves accuracies of 80.46 % (NC vs. MCI) and 95.47 % (NC vs. AD), while gated self-attention attains 82.08 % on MCI vs. AD. Ablations show that removing the MoE consistently degrades accuracy across all tasks. These findings underscore the value of input-adaptive, multimodal modeling for AD diagnosis by leveraging the complementary nature of MRI and PET.
An approach with Visual and Tabular Mamba to multimodal medical data using Mixed Fusion
This article presents a complementary approach for integrating multimodal medical data in cancer classification, based on state space models represented by the Mamba architecture. To this end, a mixed multimodal fusion architecture, called Mixed Fusion, was employed and developed to enhance the interpretability of the decision-making process. The proposed approach explores two variants of Mamba: one dedicated to visual processing, responsible for classifying the lesion image and generating probabilities associated with the target classes, and another focused on tabular processing, which uses these probabilities together with clinical and/or sociodemographic data to produce the final diagnosis. The experiments were conducted on two medical datasets: PAD-UFES-20, composed of clinical images and information associated with skin lesions, and NDB-UFES, consisting of histopathological images and sociodemographic data related to oral cancer. The results indicate slightly lower performance in balanced accuracy, compared with Transformer-based approaches, on PAD-UFES-20, and superior performance on NDB-UFES. Additionally, substantial gains were observed in the recall metric. Furthermore, the adoption of the Mixed Fusion architecture enables the application of the Shapley Additive Explanations (SHAP) method, increasing the interpretability of the results. These findings indicate that Mamba-based models constitute a suitable alternative for multimodal classification in medical data, especially in scenarios in which sensitivity is a relevant requirement.
Fair Cognitive Impairment Detection Through Unlearning
Mild Cognitive Impairment (MCI) is a medical condition characterized by a noticeable decline in memory, language, or thinking abilities. MCI detection from spontaneous speech is promising for scalable screening. However, learned models often exploit demographic cues correlated with labels, resulting in a large performance gap across subgroups. We present a multimodal framework that combines (i) cross-model fusion between modalities (speech, text, and image), and (ii) unlearning using gradient reversal that discourages the shared embedding from encoding task-irrelevant demographic attributes. Evaluated on the multilingual benchmarks TAUKADIAL and PREPARE, our method outperforms the state-of-the-art multilingual and multimodal baseline in MCI classification while substantially reducing the performance gap across patient subgroups (sex and language). We further analyze transfer across datasets, showing that demographic unlearning helps learn more robust representations for MCI detection.
Probing, Fusion, and Trustworthiness: A Systematic Evaluation of Foundation Model Representations for Multimodal Cancer Analysis
Foundation models (FMs) have emerged as powerful representation extractors for medical data, yet their generalizability to datasets under distribution shift remains underexplored. This work systematically evaluates FM-based representations on a suite of computational pathology tasks across two real-world commercial cohorts, IH-BC and IH-NSCLC, drawn from the licensed in-house (IH) oncology dataset. The analysis focuses on two modalities, whole-slide images and transcriptomic profiles, drawn from the IH multimodal data. We first benchmark unimodal probing performance across five FMs on eight downstream classification tasks, and find that image and omics representations carry complementary predictive signals. Then we investigate whether multimodal fusion can yield additional gains over unimodal baselines by comparing three image-omics fusion strategies built on paired representations. The trustworthiness of selected unimodal and multimodal pipelines is further assessed through conformal prediction. Our results show that FM representations achieve competitive performance on out-of-distribution data and that multimodal fusion helps mainly when no single modality dominates the signal. Conformal prediction reveals that in the majority of cases where a point prediction fails, the true diagnosis remains recoverable within the prediction set, reinforcing the value of uncertainty-aware inference for clinical support.
Multi-Modal Attention for Automated Disaster Damage Assessment Using Remote Sensing Imagery and Deep Learning
Timely and accurate disaster damage assessment is crucial for effective emergency response, resource allocation, and recovery. Traditional methods, which often rely on manual inspections or sparse data, are typically slow and error-prone. This paper introduces a novel framework leveraging remote sensing imagery and deep learning to automate building damage classification. Using pre- and post-disaster satellite imagery, our model categorizes buildings into four damage levels: no damage, minor damage, major damage, and destroyed. The core innovation is a multi-modal attention mechanism that fuses bi-temporal features to explicitly detect and assess structural changes. We employ a lightweight ConvNeXT-Tiny backbone to ensure efficient processing without compromising performance. Key contributions include: (1) a cross-attention module for multi-modal data fusion, (2) an optimized preprocessing pipeline for large-scale datasets, and (3) robust data augmentation techniques. Experiments on a large-scale disaster dataset demonstrate an overall classification accuracy of 94.90%. The model effectively discriminates between damage categories and remains resilient to incomplete data. This system significantly improves assessment speed and accuracy, aiding emergency responders in prioritizing interventions. This work advances automated disaster damage detection by integrating multi-temporal imagery with deep learning, offering a scalable solution for real-time response.
ProMUSE: Progressive Multi-modal Uncertainty-guided Staged Evidential Alzheimer Disease Classification
Alzheimer's disease (AD) is a fatal disorder that destroys memory and cognitive skills in the elderly population. Most treatments for AD are effective in the early stage, leading to an increasing demand for early AD diagnosis. AD diagnosis increasingly relies on multimodal data such as clinical assessments, structural Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) imaging. However, MRI and PET acquisition remain costly and not universally accessible, making full-modality inference impractical in real-world clinical workflows. We propose ProMUSE, a Progressive Multi-modal Uncertainty Guided Staged Evidential Network that adaptively determines when additional modalities are necessary, helping reduce the overall cost of data acquisition while maintaining accuracy. ProMUSE first performs evidential classification using low-cost clinical data and quantifies uncertainty via a Dirichlet-based subjective logic model. When uncertainty exceeds a learned threshold, ProMUSE progressively incorporates MRI or PET features, fusing modality-wise belief and uncertainty through Dempster-Shafer theory to obtain a calibrated multimodal prediction. This staged acquisition strategy enables accurate diagnosis while minimizing reliance on expensive imaging. Experiments on ADNI, AIBL, and OASIS across CN-AD, CN-MCI, and MCI-AD tasks demonstrate that ProMUSE achieves competitive or superior accuracy compared to full-modality baselines while reducing MRI/PET usage by 50-90%, yielding substantial cost savings. These results highlight ProMUSE as a practical, uncertainty-aware, and resource-efficient solution for real-world AD screening.
Multimodal Graph Negative Learning
Multimodal attributed graphs (MAGs) integrate graph topology with heterogeneous modality attributes, such as text and images, thereby enabling richer modeling of complex relational systems. However, such expressiveness also makes learning on MAGs depend on multiple semantic sources, including structural topology, textual and visual attributes, each of which can be regarded as a branch for node representation. Node-level branch semantic imbalance arises when these branches differ across nodes in semantic informativeness and reliability: a branch that provides discriminative semantics for one node may mislead another due to bias in modality quality or structural context. Existing methods often mitigate such heterogeneity through cross-branch agreement or alignment, implicitly treating the dominant prediction as reliable supervision. When the dominant branch is biased, forced imitation may propagate its bias to other branches and suppress original semantics that are useful for classification. We propose GraphMNL, a graph-aware multimodal negative learning framework that addresses this issue by using Negative Learning as cross-branch guidance. Instead of forcing inferior branches to imitate a teacher prediction, the model teaches them which classes a node is unlikely to belong to. GraphMNL builds a branch library, identifies dominant and inferior branches via graph-aware reliability arbitration, gates unstable transfer, and applies target-preserving negative learning over non-target classes. This design decouples target supervision from branch guidance so that supervised losses learn the correct class, while Negative Learning suppresses unlikely alternatives when branch agreement is unreliable. Through the comprehensive experimental evaluation, GraphMNL achieves the best performance on Grocery datasets with 72.47% accuracy and 76.60 F1 score on Reddit M datasets.
Unifying Acoustic Features and Text with Multimodal LLMs for Neurodegenerative Screening
Voice-based screening offers a scalable and non-invasive way to assess neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD), but their staging remains challenging due to the difficulty of integrating heterogeneous data. This paper presents NeurMLLM, an efficient multimodal generative framework for neurodegenerative disease staging. NeurMLLM first encodes the spectrograms and Mel-frequency cepstral coefficients of audio data with vision transformers and projects their representations into the embedding space of a large language model (LLM), where they are concatenated with transcript and demographic instruction tokens as a single unified sequence. The LLM is then instruction-tuned via Low-Rank Adaptation using task prompts to autoregressively predict a constrained label token, enabling a generative classification. By evaluating on the Bridge2AI-Voice dataset for fine-grained staging of AD and PD, we observe that NeurMLLM achieves strong performance, consistently outperforming classical machine learning methods and existing LLM-based approaches. The results show the high potential of multimodal LLMs in neurodegenerative disease staging, improving staging accuracy and supporting accessible deployment.
Missing-Token Prompted Reliability-Aware Fusion for Robust Polyglot Speaker Identification
Accurate and robust multimodal speaker identification is essential for multimedia understanding and biometric authentication. However, real-world polyglot scenarios pose two key challenges: speaker-discriminative representations should generalize across languages, and the model should remain reliable when face information is unavailable. To address these challenges, we propose MRAF, a Missing-Token Prompted Reliability-Aware Fusion framework for polyglot speaker identification across complete-modality, missing-face, and cross-lingual scenarios. MRAF represents unavailable face inputs with a learnable missing token instead of fixed zero-valued features, providing a trainable representation of the missing visual state. This design reduces the distribution gap caused by missing inputs and allows subsequent reliability estimation and cross-modal fusion to operate within a unified token space. To adaptively integrate modalities with different reliability, MRAF further introduces a reliability-aware cross-attention fusion module, which estimates face and audio reliability scores, normalizes them into modality weights, and applies these weights to token representations before bidirectional cross-attention. In this way, the model can emphasize reliable modality cues while suppressing unreliable ones. During training, MRAF jointly optimizes multi-branch classification losses, audio-only knowledge distillation, and center loss to improve speaker discrimination and missing-modality robustness. Experiments on the official POLY-SIM 2026 test set demonstrate the effectiveness of the proposed framework. In the final evaluation, MRAF achieves 100% accuracy on P3 and P5, and obtains competitive results on the more challenging missing-face settings P4 and P6. The source code will be released at https://github.com/MSA-LMC/MRAF.
YTClickbait21K: Human-Annotated Multimodal Dataset for YouTube Clickbait Detection Across Diverse Channels and Content Categories
Clickbait content on video-sharing platforms poses a significant challenge to information reliability, yet progress in automated detection has been constrained by the lack of large-scale, high-quality multimodal datasets. We present YTClickbait21K, a human-annotated YouTube clickbait dataset comprising 21,238 videos collected from 40 channels across 29 countries, covering diverse content categories such as news, entertainment, education, and gaming. Each sample includes structured metadata (title, description, engagement statistics) along with associated thumbnail images, enabling comprehensive multimodal analysis. To ensure annotation quality, every video was independently labeled by three annotators using a standardized decision framework that incorporates textual, visual, and cross-modal consistency cues, with final labels determined through majority voting. The dataset exhibits substantial inter-annotator agreement (k=0.65), confirming reliable labeling despite the inherent subjectivity of clickbait detection. By combining scale, annotation rigor, and multimodal richness, this dataset provides a robust benchmark for developing and evaluating machine learning models, facilitating research in cross-modal semantic understanding, and advancing automated content moderation systems.
Multimodal Brain Tumour Classification Using Feature Fusion
Clinicians diagnose brain tumors by synthesizing patient symptoms, medical history, and quantitative imaging data from modalities such as MRI and CT scans into a unified clinical judgement. However, most deep learning models rely on MRI/CT images alone, failing to replicate the clinicians multimodal reasoning. We explore a two-branch multimodal network combining raw MRI scans with 91 extracted radiomic features (intensity, texture, shape, and boundary descriptors) to classify brain tumors into glioma, meningioma, pituitary, and no-tumor. A pre-trained CNN backbone encodes the image stream, whereas a dedicated MLP encodes the radiomic stream. Both streams are fused via concatenation, gated, or bidirectional cross-modal attention strategies. Across nine experimental runs on a balanced 7,200 image dataset, all multimodal configurations outperform unimodal baselines with gated fusion achieving the best accuracy of 96.13%.
Context-Aware Deep Learning for Defect Classification in Atomic-Resolution STEM
Artificial intelligence is rapidly advancing materials characterization, yet most applications in electron microscopy rely solely on image contrast, overlooking the chemical and experimental context that shapes image formation. This limitation makes defect classification inherently ambiguous, as similar contrasts can arise from different materials or imaging conditions. Here we develop a context-aware learning framework that integrates image-derived contrast with metadata describing composition, beam energy, and detector geometry. Using a systematically constructed dataset of ~55 million simulated patches spanning 576 cases across 96 doped monolayer transition-metal dichalcogenides, we show that conditioning on contextual variables transforms defect classification from an ill-posed image-only task into a well-posed, physically grounded problem. The framework achieves over 98% accuracy on simulations and near-human agreement on experimental data, with a 94% reduction in posterior entropy. By emphasizing contextual grounding over architectural complexity, this approach links experimental image contrast to the underlying chemical and imaging conditions, supporting physically grounded defect assignments and a general pathway toward multimodal AI models for autonomous materials characterization.
Multi-View Speech Representation Learning for Parkinson's Disease Detection Using Context-guided Cross-modal Attention
Parkinson's disease (PD) is a progressive neurodegenerative disorder that frequently causes speech impairments associated with hypokinetic dysarthria. As speech production relies on the precise coordination of complex neuromuscular mechanisms, speech analysis has emerged as a promising non-invasive and cost-effective biomarker for early PD detection. Recent deep learning approaches have shown encouraging results; however, most existing methods rely on a single speech representation, potentially overlooking complementary pathological information encoded across different feature spaces. In this work, we propose a multi-branch deep learning framework for automatic PD detection from speech. Each recording is segmented into 5-second chunks and represented using three complementary modalities: Log-Mel spectrograms, MFCCs, and HuBERT embeddings extracted from raw waveforms. The spectrograms are processed using a pre-trained ResNet-18 encoder, MFCC sequences are modeled through a BiLSTM network, and raw speech is encoded using a pre-trained HuBERT model. To effectively integrate these heterogeneous representations, we introduce a context-guided cross-modal attention mechanism that dynamically weights temporal HuBERT embeddings according to the global acoustic context derived from the spectrogram and MFCC branches. Experiments conducted on the publicly available Spanish PC-GITA corpus under strict speaker-independent 5-fold cross-validation demonstrate the effectiveness of the proposed approach. The proposed architecture achieves an accuracy of 91.51%, an F1-score of 91.24%, and an AUC of 95.97%. Furthermore, ablation studies confirm the contribution of both the proposed context-guided cross-modal attention mechanism and the integration of complementary speech representations. These findings highlight the potential of heterogeneous speech modeling for robust and clinically reliable PD detection.
Synesthesia via Direct Latent Augmentation:Bypassing the Decode-Encode Loop for Cross-Modal Distillation
While multimodal integration significantly improves computer vision models, deploying them incurs prohibitive inference costs and requires scarce, perfectly paired datasets. Recent methods address this data bottleneck by synthesizing missing modalities via generative AI, yet they introduce a severe inefficiency: the Decode-Encode Loop. Specifically, information-rich generative latents are decoded into noisy raw signals, forcing the downstream classifier to waste capacity re-encoding them. To bypass this bottleneck, we propose Direct Latent Augmentation (DLA), utilizing undecoded generative latents directly as privileged information. Furthermore, to transfer this dense knowledge to a purely visual student, we introduce Multilayer Explicit Simulated Synesthesia (MESSy). Instead of enforcing rigid representation matching, which forces the student to distort its native visual features to accommodate complex multimodal topologies, MESSy uses a predictive objective to safely internalize these physical priors. Empirical results demonstrate that our framework significantly outperforms raw data augmentation and traditional distillation. Ultimately, our approach yields highly accurate unimodal students with "synesthetic" latent structures that are inherently aligned with modalities they have never directly observed.
PAMF: Prior-Aware Multimodal Fusion for Incomplete Time Series Data
In healthcare, multimodal time series tasks often operate on incomplete observations in practice, for example when ECG segments are lost because electrodes detach or an entire respiratory channel is unavailable during overnight monitoring. Such missingness typically appears in two structurally distinct patterns: within-modality missing, where values are absent within an otherwise observed modality, and modality-level missing, where an entire modality is unavailable. Existing methods typically represent unobserved data implicitly through masks or missing embeddings, without learning instance-specific missing information, and most are designed for only one missingness pattern. A natural approach is to explicitly estimate the missing data; however, existing imputation methods treat missingness uniformly despite their different structural priors, and the imputation process is often isolated from downstream tasks, preventing downstream tasks from guiding imputation toward more informative representations. To address these limitations, we present PAMF, a multimodal time-series framework that explicitly handles different missingness patterns while coupling imputation with downstream prediction through prior-aware flow matching and weight sharing. Specifically, the method initializes the flow-matching source state with type-specific priors to distinguish two missing types. It further connects imputation and classification through architecturally matched encoders with weight sharing, transferring task-relevant representations into the imputation process. Experiments on multiple multimodal healthcare time-series benchmarks show that the proposed method achieves the strongest overall downstream performance across diverse datasets and missing settings compared with existing baselines.
Multimodal Sexism Identification and Characterization using Large Language Models and Gradient Boosting
We present the AILS-NTUA submission to the EXIST 2026 Lab at CLEF, addressing multimodal sexism identification and characterization in memes (Task 2) and short-form videos (Task 3). Our system follows a feature-engineered late-fusion pipeline built around gradient-boosted regression models and hierarchical post-processing. For memes, we combine visual, textual, demographic, biometric, and LLM-derived semantic indicators designed to capture high-level cues such as stereotyping, objectification, irony, and misogyny. For videos, we investigate the effect of feature selection, frame-based visual representations, OCR-based textual features, acoustic descriptors, and sensor-derived metadata. Development results show that focused LLM-derived semantic cues improve meme sexism identification, while video performance is highly sensitive to feature dimensionality and cross-modal noise. For videos, development results favor compact feature selection, but official test results show that this conclusion does not fully transfer to unseen data, where the unfiltered representation generalizes better. Overall, our findings highlight the usefulness of targeted semantic feature engineering for static memes and the need for more robust temporal modeling in noisy short-form video settings.
Disentangled Fine-Grained Prototype Learning for Incomplete Image-Tabular Classification
The missing-modality problem poses a significant challenge in image-tabular multimodal learning across a wide range of multimedia applications, including product understanding, recommendation systems, and medical diagnosis. This challenge is particularly pronounced when the two modalities are highly heterogeneous, as images and tabular attributes differ substantially in their semantic granularity and data distributions. Existing methods learn modality-invariant representations through disentanglement and alignment over global token-averaged features, capturing only coarse cross-modal consistency and overlooking fine-grained semantic and distributional misalignment, which hampers the exploitation of complementary cues under missing modalities. To address this, we propose DFPL, a novel framework for fine-grained prototype learning. Specifically, Shared-Specific Prototype Modeling (SSPM) extracts compact and diverse shared and modality-specific prototypes, and further performs prototype-level disentanglement to suppress redundant intra-modality correlations. Additionally, we propose a Prototype-guided Fine-grained Alignment (PFA) module that jointly enforces prototype-level distribution matching and prototype-to-class semantic alignment within a unified prototype space, thereby preserving both fine-grained distributional and semantic consistency across modalities. We further introduce a Class-aware Multi-scale Aggregation (CMA) module to adaptively aggregate shared semantics and modality-specific characteristics from global and prototype levels for robust predictions. Extensive experiments on three diverse image-tabular benchmarks demonstrate the superiority of our method compared to the previous approaches under various missing-modality settings. Code will be made publicly available.
FigSIM: A Dataset for Fine-grained Suicide Severity and Figurative Language in Suicide Memes
Suicide memes are memes used to express suicide-related thoughts or comment on suicide-related issues. Suicide memes are increasingly common on social media, yet remain poorly understood and potentially harmful. There is an urgent need to better understand their characteristics and to develop appropriate content moderation strategies that limits users' exposure to potentially harmful content. Currently, the absence of annotated datasets of suicide memes remains a key barrier to developing and evaluating automated moderation approaches. In this paper, we introduce FigSIM, the first dataset designed for fine-grained analysis of suicide memes. The dataset consists of 1049 memes, each annotated for (1) fine-grained suicide severity levels, (2) figurative phenomena (e.g., metaphors), and (3) suicide-related content (e.g., suicide method depiction). We benchmark 16 unimodal and multimodal models across three tasks: figurative language, suicide severity, and suicide-related content detection. Overall, FigSIM demonstrates that suicide memes pose unique challenges for both modeling and content moderation. Analysis revealed biases, such as underprediction of higher suicide severity levels, especially for figurative memes. The dataset (including splits used for analyses) is publicly available. Content Warning: This paper contains suicide-related content that may be triggering.
Multimodal Approaches for Visually-Rich Document Type Classification: A Comparative Analysis
Document type classification in visually rich documents remains challenging, as relevant information is distributed across textual, visual, and layout modalities. To capture this complexity, current approaches rely on diverse multimodal modeling strategies, resulting in heterogeneous architectures that complicate systematic comparison. This variability is also reflected in existing comparative studies, which often rely on heterogeneous evaluation setups, further complicating systematic comparison and making it difficult to assess progress. To address these limitations, this work provides a structured analysis of multimodal design strategies across transformer- and LLM-based architectures, combined with a controlled empirical comparison within a unified experimental framework. Specifically, four representative models (LayoutLMv3, Donut, Qwen3-VL-32B-Instruct, and Qwen3-32B) are evaluated on the RVL-CDIP benchmark to systematically analyze the contributions of text, image, and layout information for document type classification, with a particular focus on contrasting OCR-dependent and OCR-free approaches. The results show that specialized multimodal Transformers outperform LLM-based approaches on visually rich and layout-intensive documents. Image information contributes most strongly to reliable classification, while OCR-derived text provides useful but secondary support. These findings highlight that multimodal processing remains essential for documents with pronounced layout structure. Overall, the study provides a systematic basis for comparing multimodal architectures and offers practical guidance for selecting effective feature combinations and model designs for document type classification.
When Tabular Foundation Models Transfer Across Modalities: A Systematic Evaluation Across 95 Datasets, 7 Modalities, and Two Regimes
We present a single classification pipeline that combines an Equiangular Tight Frame (ETF) preprocessing stage with a tabular foundation model for in-context inference, applied identically across modalities once data is mapped to fixed vector representations. We evaluate it on 95 datasets spanning seven signal modalities -- vision, audio, speech, text, molecular, time-series, and tabular. The main methodological contribution is to fix the comparison object: throughout the paper, performance is judged against the strongest lightweight tuned baseline on the same frozen features, while oracle selection, deployed selection, and specialized fine-tuning are reported separately. The pipeline is broadly competitive with strong lightweight tuned baselines on the same frozen features. It does not match the very best specialized models or heavily tuned pipelines on every task, but it stays close, and it runs much faster -- typically 4 to 200 times faster than full backbone fine-tuning, often at comparable quality. We describe how to deploy the pipeline in practice: when to apply ETF preprocessing, how to stop its training without a validation split, how to set up the in-context classifier, and how to calibrate the resulting probabilities. The calibration step is non-cosmetic: TabICL produces well-calibrated probabilities by construction, ETF preprocessing initially disrupts that calibration, and the post-hoc rescaling restores it -- yielding a per-prediction confidence signal that practitioners can use as a trust threshold for confidence-gated deployment. We also report where the pipeline should not be expected to help, and how to identify those cases in advance.
SDM-Q: Cost-Aware Staged Decision-Making for Multi-Omics Classification with Deep Q-Learning
Multi-omics data provide complementary molecular characterizations of disease phenotypes and play an important role in disease diagnosis and subtype classification in precision medicine. However, acquiring complete multi-omics profiles is expensive and time-consuming, while most existing deep learning methods assume full modality availability during inference, resulting in substantial redundancy and limited practicality in clinical settings. To address this issue, we propose SDM-Q, a reinforcement learning framework for adaptive and cost-aware multi-omics classification. Specifically, multi-omics diagnosis is reformulated as a finite-horizon sequential decision problem, where the currently acquired omics modalities define the diagnostic state at each stage. An action--value function determines whether to acquire an additional modality or terminate the decision process and output the final prediction. To balance diagnostic utility and acquisition cost, the reward is defined only at the terminal stage and jointly determined by classification correctness and cumulative modality acquisition cost. A backward stage-wise optimization strategy is introduced to improve policy consistency and training stability. Experiments on four public multi-omics datasets, including ROSMAP, LGG, BRCA, and KIPAN, demonstrate that SDM-Q effectively reduces redundant modality acquisition while maintaining competitive classification performance compared with methods using complete multi-omics inputs. In the BRCA and KIPAN datasets, more than 99% and 95% of subjects, respectively, achieve accurate classification using only a single omics modality, while the average number of acquired modalities remains below two for ROSMAP and LGG. These results suggest that cost-aware sequential decision-making provides an effective paradigm for improving the efficiency of precision medicine workflows.
MinhwaNet: Faithful but Insufficient Object Grounding in Korean Folk Painting
Korean folk painting (minhwa) is built from a small vocabulary of auspicious symbols, a tiger for protection, a pair of birds for marital harmony, a peony for wealth, that recur across many of its painted genres. This suggests an obvious computational approach, identify which symbols appear in a painting and read the genre from the inventory. Working with a public corpus that pairs whole paintings, eight-field bilingual curatorial captions, and a separate set of expert object crops, we find that this approach does not work. A model given only a list of which symbols a painting contains predicts the genre far worse than a model that fuses the image with the curatorial text, and forcing the genre representation to be object-grounded actively hurts accuracy. The visual evidence on which the genre prediction rests is nonetheless localized and inspectable. A leakage-safe object evidence map projected from a part-level detector is spatially faithful to where curators isolated symbolic objects and to a patch-based surrogate's own gradient saliency. We name this configuration a faithful-but-insufficient dissociation. The part-level explanation is honest about what the part-level model sees, yet the genre target turns on how symbols are arranged rather than on which ones appear. The same lens separates a content label that survives transfer to held-out source institutions, genre, from a style label that does not, era, a prediction we confirm on two further labels in the corpus. We release the multimodal system, a worked-example reading of one painting's evidence map against its catalogue, and a set of evaluation cautions that recur in long-tailed heritage collections.
Multi-Modal Building Inspection via Perceiver IO Fusion of Satellite and Street-Level Imagery
We present a multi-modal classification framework that fuses satellite and street-level imagery through a Perceiver IO architecture operating on spatial patch tokens from a shared DINOv2 backbone. The design naturally handles a variable number of street-level views per building without padding or fixed-size pooling, and jointly predicts multi-label roof element and roof material classes. We construct a large-scale dataset of 32,135 buildings (61,672 segments) spanning ten countries, pairing satellite images with up to eight street-level views per segment and evaluating four masking strategies for isolating the target building. We propose an RGB-M masking strategy that appends the building footprint mask as a fourth input channel, providing a soft spatial prior that outperforms hard cropping across both modalities. The Perceiver IO fusion model improves over all other fusion strategies and yields substantial per-class gains for attributes visible from street level (e.g., +11.3 AP for slate, +1.3 AP for dormers), though the satellite-only baseline retains a slight advantage in macro-averaged mAP for classes that are predominantly visible from above. These results establish a scalable, flexible architecture for multi-modal building inspection that can accommodate heterogeneous inputs and multiple output tasks.
ConceptMoE: Concept-Guided Multimodal Mixture of Experts for Interpretable Computational Pathology
Healthcare models are transitioning from unimodal prediction toward multimodal reasoning over heterogeneous diagnostic inputs. In computational pathology, for complex tumor subtypes where morphology alone can be challenging to distinguish, pathology reports and molecular measurements may provide additional diagnostic evidence alongside whole-slide images, yet existing models often fail to clarify how diverse signals assemble into recognizable diagnostic concepts. We propose ConceptMoE (Concept Multimodal MoE), which embeds concept formation directly within interaction-aware mixture-of-experts (MoE) pathways. The architecture decomposes evidence into modality-specific, redundant, and synergistic experts, which are then projected into structured concept bottlenecks mapping latent features to a hierarchy of morphology and biomarker concepts. To prevent the information loss typical of interpretable bottlenecks, we utilize residual pathways within each expert to allow task-relevant signals to flow both through the concepts and directly to the final task prediction, so that high performance is maintained alongside interpretability. Across an institutional pediatric brain tumor cohort and a public glioma cohort, the framework delivers competitive performance to unconstrained models while producing reasoning traces validated by an independent neuropathologist. In data-limited regimes, ConceptMoE improves limited-data performance, increasing macro-F1 from 56.41% to 66.70% at small training sizes compared to non-concept-informed baselines, while also showing faster training convergence consistent with the regularizing effect of concept learning. This work offers a scalable path toward high-performance medical AI that is inherently verifiable and better aligned with the complex decision-making of clinical practice.
Modular Multimodal Classification Without Fine-Tuning: A Simple Compositional Approach
We introduce CoMET, \textit{\textbf{C}omposing \textbf{M}odality \textbf{E}ncoders with \textbf{T}abular foundation models}, a simple yet highly competitive method for multimodal classification: pass each modality through a frozen pre-trained backbone, compress the resulting embeddings with PCA, and concatenate as input into a Tabular Foundation Model (TFM) for prediction. We show that PCA alone suffices to act as an adaptor yielding strong, robust performance across modalities. When the \texttt{CLS} tokens of the foundation model align poorly with downstream tasks, we propose \textbf{PALPooling}, a lightweight adaptive token pooler that consistently improves representation quality. By composing strong frozen representation learning backbones with TFMs, our approach achieves state-of-the-art results across diverse multimodal benchmarks without any training. On hierarchical tasks with large fine-grained class spaces, our approach enables fast and scalable classification, handling datasets with over 500,000 samples and 2,000 classes without any fine-tuning. Overall, our results show that the composition of foundation models is a simple, yet powerful, out-of-the-box solution for multimodal learning, challenging the necessity of complex, end-to-end training pipelines for new problems.
QwenSafe: Multimodal Content Rating Description Identification via Preference-Aligned VLMs
Mobile app marketplaces require developers to disclose standardized content rating descriptors (CRDs) to inform users about potentially sensitive or restricted content. Ensuring the accuracy and consistency of these disclosures remains challenging due to the multimodal nature of app content, which spans textual descriptions and visual interfaces. In this paper, we present QwenSafe, a Vision-Language Model (VLM) designed to automatically identify the presence of Apple-defined CRDs by jointly reasoning over app metadata and screenshots. To enable scalable training for this task, we introduce metadata2CRD, a data-construction pipeline that synthesizes descriptor-aligned question-answer pairs by combining app descriptions, screenshots, and formal descriptor definitions. We adapt Qwen3-VL-8B using supervised fine-tuning followed by Direct Preference Optimization (DPO) to align model predictions with descriptor-specific evidence and explanations across visual and textual modalities. We evaluate QwenSafe on 12 Apple-defined content rating descriptors and compare it against state-of-the-art vision-language models, including Qwen3-VL, LLaVA-1.6, and Gemini-2.5-Flash. QwenSafe consistently outperforms all baselines in binary CRD classification, achieving improvements in positive-class recall of 111.8%, 36.1%, and 2.1%, respectively. Our results demonstrate that descriptor-aware multimodal alignment substantially improves automated content classification and highlights the potential of vision-language models to support scalable and consistent content rating in mobile app marketplaces.
CodeBind: Decoupled Representation Learning for Multimodal Alignment with Unified Compositional Codebook
Multimodal representation alignment is pivotal for large language models and robotics. Traditional methods are often hindered by cross-modal information discrepancies and data scarcity, leading to suboptimal alignment spaces that overlook modality-unique features. We propose CodeBind, a framework that optimizes multimodal representation spaces through a modality-shared-specific codebook design. By incrementally aligning target and bridging modalities, CodeBind bypasses the need for fully paired data. Unlike traditional hard alignment, CodeBind decomposes features into shared components for semantic consistency and specific components for modality-unique details. This design utilizes a compositional vector quantization scheme, where a shared codebook bridges modality gaps and modality-specific codebooks mitigate representation bias by preventing dominant modalities from overshadowing others. Validated across nine modalities (text, image, video, audio, depth, thermal, tactile, 3D point cloud, EEG), CodeBind achieves state-of-the-art performance in multimodal classification and retrieval tasks.
A Conflict-aware Evidential Framework for Reliable Sleep Stage Classification
Multi-view learning has been widely applied for sleep stage classification using multi-modal data. However, existing methods typically assume that different modalities are well-aligned, which is often unattainable in real-world scenarios, thereby compromising the reliability of the staging results. In this paper, we propose ConfSleepNet, a conflict-aware evidential framework that dynamically resolves inter-view conflicts. The framework consists of multi-view evidence extraction and conflict-aware aggregation. In the first phase, it learns category-related evidence from different modalities, which represents the degree of support for individual sleep stages. Considering the inherent characteristics of varying modalities, we propose hybrid category structures for different modalities to promote more reasonable evidence learning. In the second phase, view-specific opinions, including prediction results and uncertainty, are constructed from the learned evidence. Notably, we propose a novel conflict-aware aggregation method that integrates these view-specific opinions into a reliable joint decision. This mechanism can effectively resolve conflicts among opinions and synthesize them into a reliable joint decision. Both theoretical analysis and experimental results demonstrate the effectiveness of ConfSleepNet in sleep staging tasks. The code is available at https://github.com/By4te/ConfSleepNet_ICML2026/.
DeepArrhythmia: Segment-Contextualized ECG Arrhythmia Classification via Selective Evidence Acquisition
Beat-level Electrocardiography (ECG) arrhythmia detection aims to assign an arrhythmia class to each beat in a recording, yet many existing systems treat beats as isolated local instances. This is limiting because beat labels often depend on multi-beat rhythm context, including timing, compensatory pauses, and beat-to-beat morphological consistency. We present DeepArrhythmia, a tool-grounded multimodal framework for segment-contextualized beat-level ECG arrhythmia classification. Given a multi-beat ECG segment, DeepArrhythmia combines the raw ECG signal and a rendered waveform image, localizes R peaks to identify beat instances, and produces structured beat-level predictions. The framework decouples physiological measurement from evidence integration using specialized tools for beat localization, numerical rhythm--morphology extraction, and morphology-focused textual analysis. DeepArrhythmia uses segment-level confidence to route between minimal and rich evidence states, since richer physiological evidence is not uniformly useful. This agentic design integrates rhythm context, explicit physiological grounding, and selective evidence acquisition for decision making.
Machine Learning-Driven Multimodal Spectroscopic Liquid Biopsy for Early Multicancer Detection
Cancer is one of the leading causes of death worldwide, making the development of rapid, minimally invasive, label-free and scalable diagnostic strategies a major challenge in modern oncology. In this context, spectroscopic liquid biopsy has emerged as a promising alternative, as it enables the holistic characterization of biochemical alterations in biological fluids. In this work, we propose a multimodal spectroscopic liquid biopsy framework for multicancer detection based on the combination of Fourier Transform Infrared (FTIR) spectroscopy, Raman spectroscopy, and Excitation-Emission Matrix (EEM) fluorescence spectroscopy together with Machine Learning (ML) methodologies. Serum samples from breast cancer patients, colorectal cancer patients, and healthy controls were analyzed through the three spectroscopic modalities. After modality-specific preprocessing, low-level data fusion (LLDF) was employed to integrate the complementary biochemical information encoded within the different spectroscopic measurements, and classification was performed using XGBoost models. Seven experimental configurations were evaluated, including the three unimodal approaches, all pairwise bimodal configurations, and the full multimodal approach of FTIR, Raman, and EEM fluorescence. The results show that although several individual modalities achieved high discrimination performance, the multimodal fusion provided the most balanced overall results, reaching a ROC-AUC of 0.997 for breast cancer and 0.994 for colorectal cancer, together with highly balanced sensitivity and specificity values.
Resilient Vision-Tabular Multimodal Learning under Modality Missingness
Multimodal deep learning has shown strong potential in medical applications by integrating heterogeneous data sources such as medical images and structured clinical variables. However, most existing approaches implicitly assume complete modality availability, an assumption that rarely holds in real-world clinical settings where entire modalities and individual features are frequently missing. In this work, we propose a multimodal transformer framework for joint vision-tabular learning explicitly designed to operate under pervasive modality missingness, without relying on imputation or heuristic model switching. The architecture integrates three components: a vision, a tabular, and a multimodal fusion encoder. Unimodal representations are weighted through learnable modality tokens and fused via intermediate fusion with masked self-attention, which excludes missing tokens and modalities from information aggregation and gradient propagation. To further enhance resilience, we introduce a modality-dropout regularization strategy that stochastically removes available modalities during training, encouraging the model to exploit complementary information under partial data availability. We evaluate our approach on the MIMIC-CXR dataset paired with structured clinical data from MIMIC-IV for multilabel classification of 14 diagnostic findings with incomplete annotations. Two parallel systematic stress-test protocols progressively increase training and inference missingness in each modality separately, spanning fully multimodal to fully unimodal scenarios. Across all missingness regimes, the proposed method consistently outperforms representative baselines, showing smoother performance degradation and improved robustness. Ablation studies further demonstrate that attention-level masking and intermediate fusion with joint fine-tuning are key to resilient multimodal inference.
Multi-domain Multi-modal Document Classification Benchmark with a Multi-level Taxonomy
Document classification forms the backbone of modern enterprise content management, yet existing benchmarks remain trapped in oversimplified paradigms -- single domain settings with flat label structures -- that bear little resemblance to the hierarchical, multi-modal, and cross-domain nature of real-world business documents. This gap not only misrepresents practical complexity but also stifles progress toward industrially viable document intelligence. To bridge this gap, we construct the first Multi-level, Multi-domain, Multi-modal document classification Benchmark (MMM-Bench). MMM-Bench includes (1) a deeply hierarchical taxonomy spanning five levels that capture the authentic organizational logic of business documentation; and (2) 5,990 real-world multi-modal documents meticulously curated from 12 commercial domains in Alibaba. Each document is manually annotated with a complete hierarchical path by domain experts. We establish comprehensive baselines on MMM-Bench, which consists of open-weight models and API-based models. Through systematic experiments, we identify four fundamental challenges within MMM-Bench and propose corresponding insights. To provide a solid foundation for advancing research in multi-level, multi-domain document classification, we release all of the data and the evaluation toolkit of MMM-Bench at https://github.com/MMMDC-Bench/MMMDC-Bench.
Simultaneous Long-tailed Recognition and Multi-modal Fusion for Highly Imbalanced Multi-modal Data
Long-tailed distributions in class-imbalanced data present a fundamental challenge for deep learning models, which tend to be biased toward majority classes. While recent methods for long-tailed recognition have mitigated this issue, they are largely restricted to single-modal inputs and cannot fully exploit complementary information from diverse data sources. In this work, we introduce a new framework for long-tailed recognition that explicitly handles multi-modal inputs. Our approach extends multi-expert architectures to the multi-modal setting by fusing heterogeneous data into a unified representation while leveraging modality-specific networks to estimate the informativeness of each modality. These confidence-guided weights dynamically modulate the fusion process, ensuring that more informative modalities contribute more strongly to the final decision. To further enhance performance, we design specialized training and test procedures that accommodate diverse modality combinations, including images and tabular data. Extensive experiments on benchmark and real-world datasets demonstrate that the proposed approach not only effectively integrates multi-modal information but also outperforms existing methods in handling long-tailed, class-imbalanced scenarios, highlighting its robustness and generalization capability.
Learning predictive models for combinations of heterogeneous proteomic data sources
Multiple technologies that measure expression levels of protein mixtures in the human body offer a potential for detection and understanding the disease. The recent increase of these technologies prompts researchers to evaluate the individual and combined utility of data generated by the technologies. In this work, we study two data sources to measure the expression of protein mixtures in the human body: whole-sample MS profiling and multiplexed protein arrays. We investigate the individual and combined utility of these technologies by learning and testing a variety of classification models on the data from a pancreatic cancer study. We show that for the combination of these two (heterogeneous) datasets, classification models that work well on one of them individually fail on the combination of the two datasets. We study and propose a class of model fusion methods that acknowledge the differences and try to reap most of the benefits from their combination.
Multimodal Stepwise Clinically-Guided Attention Learning for Pathological Complete Response Prediction in Breast Cancer
Pathological complete response (pCR) is a key prognostic factor in breast cancer patients undergoing neoadjuvant therapy, strongly associated with long-term survival and treatment personalization. However, accurate pre-treatment pCR prediction remains challenging due to severe class imbalance and limited generalizability across diverse clinical settings. In this work, we propose a multimodal stepwise clinically-guided attention learning framework for pCR prediction from breast magnetic resonance imaging (MRI), designed to address these limitations through medically grounded spatial guidance and multimodal integration. The approach follows a stepwise training strategy inspired by physician reasoning: the model first learns global discriminative imaging patterns, then attention mechanisms are introduced to constrain the network toward tumor regions, and finally clinical variables are integrated to refine decision-making. This guidance strategy encourages prioritization of task-relevant features, improving identification of responders despite their limited representation in the dataset. Moreover, grounding attention in anatomically consistent tumor regions reduces reliance on dataset-specific patterns, thereby enhancing cross-institutional generalization. The framework is evaluated through external validation across heterogeneous MRI cohorts. Compared to non-guided single-stage baselines, the proposed approach improves sensitivity while maintaining competitive specificity, and produces anatomically coherent attention maps that support interpretation of the model's predictions. These findings highlight the potential of clinically-guided multimodal attention learning for robust and generalizable pCR prediction in breast cancer.
Multimodal Deep Generative Model for Semi-Supervised Learning under Class Imbalance
When modeling class-imbalanced data, it is crucial to address the imbalance, as models trained on such data tend to be biased towards the majority classes. This problem is amplified under partial supervision, where pseudo-labels for unlabeled data are predicted based on imbalanced labeled data, propagating the bias. While recent semi-supervised models address class imbalance, they typically assume single-modal input data. However, with the growing availability of multimodal data, it is essential to leverage complementary modalities. In this article, we propose a multimodal deep generative model for semi-supervised learning under class imbalance. Our approach uses separate encoders for each modality, sharing latent variables across modalities, and simplifies joint posterior computation with a product-of-experts method. To further address class imbalance, we replace typical Gaussian distributions with Student's t-distributions for the prior, encoder, and decoder, better capturing the heavy-tailed latent distributions in imbalanced data. We derive a new objective function for training the proposed model on both labeled and unlabeled data using -power divergence. Empirical results on benchmark and real-world datasets demonstrate that our model outperforms baseline methods in generalization, achieving superior classification performance for partially labeled multimodal data with imbalanced class distributions.
Virtual Scanning for NSCLC Histology: Investigating the Discriminatory Power of Synthetic PET
Accurate histological differentiation between adenocarcinoma (ADC) and squamous cell carcinoma (SCC) is critical for personalized treatment in non-small cell lung cancer (NSCLC). While [F]FDG PET/CT is a standard tool for the clinical evaluation of lung cancer, its utility is often limited by high costs and radiation exposure. In this paper, we investigate the feasibility of "virtual scanning" as a feature-enhancement strategy by evaluating whether synthetic PET data can provide complementary feature representations to supplement anatomical CT scans in histological subtype classification. We propose a framework that leverages a 3D Pix2Pix Generative Adversarial Network (GAN), pretrained on the FDG-PET/CT Lesions dataset, to synthesize pseudo-PET volumes from anatomical CT scans. These synthetic volumes are integrated with structural CT data within the MINT framework, a multi-stage intermediate fusion architecture. Our experiments, conducted on a multi-center dataset of 714 subjects, demonstrate that the inclusion of synthetic metabolic features significantly improves classification performance over a CT-only baseline. The multimodal approach achieved a statistically significant increase in the Area Under the Curve (AUC) from 0.489 to 0.591 and improved the Geometric Mean (GMean) from 0.305 to 0.524. These results suggest that synthetic PET scans provide discriminatory metabolic cues that enable deep learning models to exploit complementary cross-modal information, offering a potential feature-enhancement strategy for clinical scenarios where physical PET scans are unavailable.
From Static Analysis to Audience Dissemination: A Training-Free Multimodal Controversy Detection Multi-Agent Framework
Multimodal controversy detection (MCD) identifies controversial content in videos and their associated user comments, to support risk management for social video platforms.Prior research frames MCD as a static representation learning task, where features are directly extracted from videos and their accompanying comments. However, these methods fail to capture the diverse perspectives and evaluations from different audience groups. Inspired by the real-world process of content dissemination among audiences, we propose AuDisAgent, a training-free multi-agent framework that reformulates MCD as a dynamic propagation process.Our framework explicitly models audience dissemination through a structured multi-agent system. First, three specialized Screening Agents (Video Agent, Comment Agent, and Interaction Agent) conduct initial assessments from visual, textual, and cross-modal perspectives, respectively. For samples where the three agents cannot reach a consensus, a Viewing Panel Agent is activated to simulate post-screening discussions among audiences with diverse backgrounds and stances. This mechanism models how different audience groups interpret and react to the same content, uncovering latent controversial content that may emerge during the dissemination process. Finally, an Arbitration Agent renders the final judgment based on the complete reasoning chain from the preceding steps.In addition, to address the "cold-start" scenario where newly released videos have few or no comments, we design a Comment Bootstrapping Strategy that leverages historical public comments from semantically similar videos as the initial comment context. Extensive experiments on a public dataset demonstrate that our framework significantly outperforms existing state-of-the-art (SOTA) methods in both rich-comment and limited-comment scenarios.
MM-StanceDet: Retrieval-Augmented Multi-modal Multi-agent Stance Detection
Multimodal Stance Detection (MSD) is crucial for understanding public discourse, yet effectively fusing text and image, especially with conflicting signals, remains challenging. Existing methods often face difficulties with contextual grounding, cross-modal interpretation ambiguity, and single-pass reasoning fragility. To address these, we propose Retrieval-Augmented Multi-modal Multi-agent Stance Detection (MM-StanceDet), a novel multi-agent framework integrating Retrieval Augmentation for contextual grounding, specialized Multimodal Analysis agents for nuanced interpretation, a Reasoning-Enhanced Debate stage for exploring perspectives, and Self-Reflection for robust adjudication. Extensive experiments on five datasets demonstrate MM-StanceDet significantly outperforms state-of-the-art baselines, validating the efficacy of its multi-agent architecture and structured reasoning stages in addressing complex multimodal stance challenges.
JI-ADF: Joint-Individual Learning with Adaptive Decision Fusion for Multimodal Skin Lesion Classification
Skin lesion classification is essential for early dermatological diagnosis, yet many existing computer-aided systems rely primarily on dermoscopic images and underutilize the multimodal evidence routinely available in clinical practice. To address this gap, we propose \textbf{JI-ADF}, a trimodal deep learning framework that integrates dermoscopic images, clinical photographs, and structured patient metadata for clinically grounded skin lesion classification. The proposed architecture combines joint multimodal representation learning with modality-specific auxiliary supervision and an adaptive decision fusion mechanism that dynamically calibrates modality contributions on a per-sample basis. To enhance cross-modal reasoning while preserving modality-specific evidence, we further introduce a multimodal fusion attention (MMFA) module. We evaluate JI-ADF on the large-scale MILK10k benchmark, which reflects real-world clinical acquisition conditions and severe class imbalance. The proposed method demonstrates strong and well-balanced performance across lesion categories, improving sensitivity and Dice score while maintaining high specificity and good calibration. Extensive analyses, including modality ablation, calibration evaluation, and Grad-CAM visualization, further confirm the robustness and clinically meaningful behavior of the model. These results indicate that JI-ADF provides a reliable and practical foundation for multimodal skin lesion classification in real-world clinical settings.
VTBench: A Multimodal Framework for Time-Series Classification with Chart-Based Representations
Time-series classification (TSC) has advanced significantly with deep learning, yet most models rely solely on raw numerical inputs, overlooking alternative representations. While texture-based encodings such as Gramian Angular Fields (GAF) and Recurrence Plots (RP) convert time series into 2D images, they often require heavy preprocessing and yield less intuitive representations. In contrast, chart-based visualizations offer more interpretable alternatives and show promise in specific domains; however, their effectiveness remains underexplored, with limited systematic evaluation across chart types, visual encoding choices, and datasets. In this work, we introduce VTBench, a systematic and extensible framework that re-examines TSC through multimodal fusion of raw sequences and chart-based visualizations. VTBench generates lightweight, human-interpretable plots -- line, area, bar, and scatter, providing complementary views of the same signal. We develop a modular architecture supporting multiple fusion strategies, including single-chart visual-numerical fusion, multi-chart visual fusion, and full multimodal fusion with raw inputs. Through experiments across 31 UCR datasets, we show that: (1) chart-only models are competitive in selected settings, particularly on smaller datasets; (2) combining multiple chart types can improve accuracy by capturing complementary visual cues; and (3) multimodal models improve or maintain performance when visual features provide non-redundant information, but may degrade accuracy when they introduce redundancy. We further distill practical guidelines for selecting chart types, fusion strategies, and configurations. VTBench establishes a unified foundation for interpretable and effective multimodal time-series classification.
A Multimodal Pre-trained Network for Integrated EEG-Video Seizure Detection
Reliable seizure detection in mouse models is essential for preclinical epilepsy research, yet manual review of synchronized video-EEG recordings is labor-intensive and single-modality systems fail for complementary reasons: video-based methods are easily confounded by benign behaviors, whereas EEG-based methods are vulnerable to ictal motion artifacts. We present EEGVFusion, a multimodal framework that combines self-supervised EEG representation learning, spatio-temporal video encoding, optimal-transport alignment, and bidirectional cross-attention to integrate neural and behavioral evidence. We also curate an expert-annotated dataset of synchronized EEG and video recordings comprising 93 sessions from 15 mice for training and evaluation. In the random-session split, EEGVFusion achieved a Balanced Accuracy of 0.9957 with perfect event sensitivity and an Event FAR of 0.6250 FP/h, indicating strong seizure detection performance with a low false-alarm burden. In a single held-out-subject evaluation with Subject 110 reserved for testing, EEGVFusion achieved a Balanced Accuracy of 0.9718 and reduced Event FAR from 2.7250 FP/h for the EEG-only counterpart to 0.4833 FP/h while preserving perfect event sensitivity. Targeted ablations further showed that EEG pre-training and OT alignment help reduce false alarms while preserving event sensitivity.
ASR-Agnostic Multimodal Spectrotemporal Modeling for Early Dementia Detection
Speech recruits the same executive, attentional, and working memory processes underlying instrumental activities of daily living, or IADLs, providing a non-invasive proxy for cognitive assessment. Yet most speech-based dementia detection systems depend on transcription, discard within-recording temporal structure, and are validated on a single English corpus with known recording artifacts. We propose an ASR-agnostic framework operating directly on Mel spectrograms. Our key contribution is extracting spectrotemporal displacement fields from consecutive spectrogram frames, capturing shifting spectral energy patterns as digital biomarkers of cognitive decline. These features are fused with CNN-ConvGRU acoustic embeddings via a learned cross-attention mechanism and aggregated using a Transformer encoder with learnable query pooling. A composite temporal loss enforces smoothness and contrastive coherence across segments. We train independent models on English DementiaBank, Slovak EWA-DB, and Spanish Ivanova corpora, using clinical elicitation protocols taxing IADL-relevant cognitive domains. The Slovak model achieves 83.9% accuracy, and Spanish achieves, while the English baseline yields 53.2%, confirming known artifacts. Cross-lingual ablation studies reveal distinct fusion regimes: removing cross-attention collapses Spanish performance to 53.7%, below unimodal models, while the Slovak audio encoder alone outperforms the full model, 93.7% vs. 83.9%, and all English configurations remain near chance. Thus, multimodal fusion's value is corpus-dependent: essential when signal is distributed across modalities, counterproductive when one dominates, and irrelevant when no signal exists. Auxiliary temporal losses converge to language-invariant values, indicating cross-lingual architectural stability.
DARC-CLIP: Dynamic Adaptive Refinement with Cross-Attention for Meme Understanding
Memes convey meaning through the interaction of visual and textual signals, often combining humor, irony, and offense in subtle ways. Detecting harmful or sensitive content in memes requires accurate modeling of these multimodal cues. Existing CLIP-based approaches rely on static fusion, which struggles to capture fine grained dependencies between modalities. We propose DARC-CLIP, a CLIP-based framework for adaptive multimodal fusion with a hierarchical refinement stack. DARC-CLIP introduces Adaptive Cross-Attention Refiners to for bidirectional information alignment and Dynamic Feature Adapters for task-sensitive signal adaptation. We evaluate DARC-CLIP on the PrideMM benchmark, which includes hate, target, stance, and humor classification, and further test generalization on the CrisisHateMM dataset. DARC-CLIP achieves highly competitive classification accuracy across tasks, with significant gains of +4.18 AUROC and +6.84 F1 in hate detection over the strongest baseline. Ablation studies confirm that ACAR and DFA are the main contributors to these gains. These results show that adaptive cross-signal refinement is an effective strategy for multimodal content analysis in socially sensitive classification.
STEP-PD: Stage-Aware and Explainable Parkinson's Disease Severity Classification Using Multimodal Clinical Assessments
Parkinson's disease (PD) is a progressive disorder in which symptom burden and functional impairment evolve over time, making severity staging essential for clinical monitoring and treatment planning. However, many computational studies emphasize binary PD detection and do not fully use repeated follow-up clinical assessments for stage-aware prediction. This study proposes STEP-PD, a severity-aware machine learning framework to classify PD severity using clinically interpretable boundaries. It leverages all available visits from the Parkinson's Progression Markers Initiative (PPMI) and integrates routinely collected subjective questionnaires and objective clinician-assessed measures. Disease severity is defined using Hoehn and Yahr staging and grouped into three clinically meaningful categories: Healthy, Mild PD (stages 1-2), and Moderate-to-Severe PD (stages 3-5). Three binary classification problems and a three-class severity task were evaluated using stratified cross-validation with imbalance-aware training. To enhance interpretability, SHAP was used to provide global explanations and local patient-level waterfall explanations. Across all tasks, XGBoost achieved the strongest and most stable performance, with accuracies of 95.48% (Healthy vs. Mild), 99.44% (Healthy vs. Moderate-to-Severe), and 96.78% (Mild vs. Moderate-to-Severe), and 94.14% accuracy with 0.8775 Macro-F1 for three-class severity classification. Explainability results highlight a shift from early motor features to progression-related axial and balance impairments. These findings show that multimodal clinical assessments within the PPMI cohort can support accurate and interpretable visit-level PD severity stratification.
Multimodal Fusion of Histopathology Images and Electronic Health Records for Early Breast Cancer Diagnosis
Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on histopathology image classification, and machine learning models on structured electronic health records (EHR) have shown utility for clinical risk stratification, most existing work treats these modalities in isolation. This paper presents a systematic multimodal framework that integrates patch-level histopathology features from the BreCaHAD dataset with structured clinical data from MIMIC-IV. We train and evaluate unimodal image models (a simple CNN baseline and ResNet-18 with transfer learning), unimodal tabular models (XGBoost and a multilayer perceptron), and an intermediate-fusion model that concatenates latent representations from both modalities. ResNet-18 achieves near-perfect accuracy (1.000) and AUC (1.000) on three-class patch-level classification, while XGBoost achieves 98% accuracy on the EHR prediction task. The intermediate fusion model yields a macro-average AUC of 0.997, outperforming all unimodal baselines and delivering the largest improvements on the diagnostically critical but class-imbalanced mitosis category (AUC 0.994). Grad-CAM and SHAP interpretability analyses validate that model decisions align with established pathological and clinical criteria. Our results demonstrate that multimodal integration delivers meaningful improvements in both predictive performance and clinical transparency.
IMA-MoE: An Interpretable Modality-Aware Mixture-of-Experts Framework for Characterizing the Neurobiological Signatures of Binge Eating Disorder
Binge eating disorder (BED) is the most prevalent eating disorder. However, current diagnostic frameworks remain largely grounded in symptom-based criteria rather than underlying biological mechanisms, thereby limiting early detection and the development of biologically-informed interventions. Emerging studies have begun to investigate the neurobiological signatures of BED, yet their findings are often difficult to generalize due to the reliance on hypothesis-driven parametric models, single-modality analyses, and limited data diversity. Therefore, there is a critical need for advanced data-driven frameworks capable of modeling multimodal data to uncover generalizable and biologically meaningful signatures of BED. In this study, we propose the Interpretable Modality-Aware Mixture-of-Experts (IMA-MoE), a novel architecture designed to integrate heterogeneous neuroimaging, behavioral, hormonal, and demographic measures within a unified predictive framework. By encoding each measure as a distinct token, IMA-MoE enables flexible modeling of cross-modal dependencies while preserving modality-specific characteristics. We further introduce a token-importance mechanism to enhance interpretability by quantifying the contribution of each measure to model predictions. Evaluated on the large-scale Adolescent Brain Cognitive Development (ABCD) dataset, IMA-MoE demonstrates superior performance in differentiating BED from healthy controls compared with baseline methods, while revealing sex-specific predictive patterns, with hormonal measures contributing more prominently to prediction in females. Collectively, these findings highlight the promise of interpretable, data-driven multimodal modeling in advancing biologically-informed characterization of BED and facilitating more precise and personalized interventions in neuropsychiatric disorders.