Multimodal Diffusion Models

While physically-based rendering (PBR) simulates light transport that guarantees physical realism, achieving true photorealistic rendering (PRR) demands prohibitive time and labor, and still struggles to capture the intractable richness of the real world. We propose GeRM, the first multimodal generative rendering model to bridge the gap from PBR to PRR (P2P). We formulate this P2P transition by learning a distribution transfer vector (DTV) field to direct the generative process. To achieve this, we introduce a multi-condition ControlNet that synthesizes PBR images and progressively transitions them into PRR images, guided by G-buffers, text prompts, and cues for enhanced regions. To improve the model's grasp of the image distribution shift driven by text prompts, we propose a residual perceptual transfer mechanism to associate text prompts with corresponding targeted modification regions, which more clearly defines the incremental component updates. To supervise this transfer process, we introduce a multi-agent visual language model framework to construct an expert-guided pairwise transfer dataset, named P2P-50K, where each paired sample corresponds to a specific transfer vector in the DTV field. Extensive experiments demonstrate that GeRM synthesizes high-quality controllable images and outperforms state-of-the-art baselines across diverse applications, including PBR and PRR image synthesis and editing.

Generating realistic visual defects is crucial for alleviating the scarcity of abnormal samples in anomaly detection, yet existing methods often rely on category-specific few-shot adaptation and struggle to generalize across objects, defect types, and domains. This limitation stems in part from the lack of paired defect editing data and the fine-grained nature of defect appearance, where subtle variations in scale, texture, and morphology must be preserved while maintaining consistency with the target scene. To address this challenge, we introduce UDG, a dataset of 300K normal-abnormal-mask-caption quadruplets curated from diverse defect-related scenarios, and present UniDG, a unified defect generation model. UniDG formulates defect synthesis as Defect-Context Editing: it extracts reference defect context with adaptive cropping, organizes reference and target inputs in a structured diptych format, and fuses multimodal conditions through MM-DiT attention. We further develop a two-stage training strategy: Diversity-SFT learns diverse transferable defect priors from paired editing data, while optional Consistency-RFT can further improve reference adherence, local realism, and defect-category consistency. Without per-category fine-tuning or using MVTec-AD/VisA for training, UniDG outperforms prior few-shot anomaly generation and image insertion/editing baselines in both synthesis quality and downstream single- and multi-class anomaly detection/localization.

Diffusion large language models (dLLMs) are emerging as promising alternatives to autoregressive (AR) LLMs. Recently, this paradigm has been extended to multimodal tasks, leading to the development of diffusion multimodal large language models (dMLLMs). These models are expected to retain the reasoning capabilities of LLMs while enabling faster inference through parallel generation. However, when combined with Chain-of-Thought (CoT) reasoning, dMLLMs exhibit two critical issues. First, we observe that dMLLMs often generate the final answer token at a very early timestep. This trend indicates that the model determines the answer before sufficient reasoning, leading to degraded reasoning performance. Second, during the initial timesteps, dMLLMs show minimal dependency on visual prompts, exhibiting a fundamentally different pattern of visual information utilization compared to AR vision-language models. In summary, these findings indicate that dMLLMs tend to generate premature final answers without sufficiently grounding on visual inputs. To address these limitations, we propose Position and Step Penalty (PSP) and Visual Reasoning Guidance (VRG). PSP penalizes tokens in later positions during early timesteps, delaying premature answer generation and encouraging progressive reasoning across timesteps. VRG, inspired by classifier-free guidance, amplifies visual grounding signals to enhance the model's alignment with visual evidence. Extensive experiments across various dMLLMs demonstrate that our method achieves up to 7.5% higher accuracy while delivering more than 3x speedup compared to reasoning with four times more diffusion steps.

Evolution is an extraordinary engine for enzymatic diversity, yet the chemistry it has explored remains a narrow slice of what DNA can encode. Deep generative models can design new proteins that bind ligands, but none have created enzymes without pre-specifying catalytic residues. We introduce DISCO (DIffusion for Sequence-structure CO-design), a multimodal model that co-designs protein sequence and 3D structure around arbitrary biomolecules, as well as inference-time scaling methods that optimize objectives across both modalities. Conditioned solely on reactive intermediates, DISCO designs diverse heme enzymes with novel active-site geometries. These enzymes catalyze new-to-nature carbene-transfer reactions, including alkene cyclopropanation, spirocyclopropanation, B-H, and C(sp$^3$)-H insertions, with high activities exceeding those of engineered enzymes. Random mutagenesis of a selected design further confirmed that enzyme activity can be improved through directed evolution. By providing a scalable route to evolvable enzymes, DISCO broadens the potential scope of genetically encodable transformations. Code is available at https://github.com/DISCO-design/DISCO.

Accurate diagnosis and treatment of complex diseases require integrating histological, molecular, and clinical data, yet in practice these modalities are often incomplete owing to tissue scarcity, assay cost, and workflow constraints. Existing computational approaches attempt to impute missing modalities from available data but rely on task-specific models trained on narrow, single source-target pairs, limiting their generalizability. Here we introduce MuPD (Multimodal Pathology Diffusion), a generative foundation model that embeds hematoxylin and eosin (H&E)-stained histology, molecular RNA profiles, and clinical text into a shared latent space through a diffusion transformer with decoupled cross-modal attention. Pretrained on 100 million histology image patches, 1.6 million text-histology pairs, and 10.8 million RNA-histology pairs spanning 34 human organs, MuPD supports diverse cross-modal synthesis tasks with minimal or no task-specific fine-tuning. For text-conditioned and image-to-image generation, MuPD synthesizes histologically faithful tissue architectures, reducing Fréchet inception distance (FID) scores by 50% relative to domain-specific models and improving few-shot classification accuracy by up to 47% through synthetic data augmentation. For RNA-conditioned histology generation, MuPD reduces FID by 23% compared with the next-best method while preserving cell-type distributions across five cancer types. As a virtual stainer, MuPD translates H&E images to immunohistochemistry and multiplex immunofluorescence, improving average marker correlation by 37% over existing approaches. These results demonstrate that a single, unified generative model pretrained across heterogeneous pathology modalities can substantially outperform specialized alternatives, providing a scalable computational framework for multimodal histopathology.

Despite advancements in generating visually stunning content, video diffusion models (VDMs) often yield physically inconsistent results due to pixel-only reconstruction. To address this, we propose MMPhysVideo, the first study to enhance physical plausibility in video generation through joint multimodal modeling. We recast perceptual cues, specifically semantics, geometry, and spatio-temporal trajectories, into a unified pseudo-RGB format, enabling VDMs to directly capture complex physical dynamics. To mitigate cross-modal interference, we propose a Bidirectionally Controlled Teacher architecture, which utilizes parallel branches to fully decouple RGB and perception processing and adopts two zero-initialized control links to gradually establish pixel-wise consistency. For inference efficiency, the teacher's physical prior is distilled into a single-stream student model via representation alignment. Furthermore, we present MMPhysPipe, an end-to-end data curation and annotation pipeline tailored for constructing physics-rich multimodal datasets. MMPhysPipe employs a vision-language model (VLM) guided by a chain-of-visual-evidence rule to pinpoint physical subjects, enabling expert models to extract multi-granular perceptual information. Without additional inference costs, MMPhysVideo consistently improves physical plausibility of advanced models on the Videophy and PhyGenbench benchmarks and achieves superior performance among existing methods.

Recent multimodal face generation models address the spatial control limitations of text-to-image diffusion models by augmenting text-based conditioning with spatial priors such as segmentation masks, sketches, or edge maps. This multimodal fusion enables controllable synthesis aligned with both high-level semantic intent and low-level structural layout. However, most existing approaches typically extend pre-trained text-to-image pipelines by appending auxiliary control modules or stitching together separate uni-modal networks. These ad hoc designs inherit architectural constraints, duplicate parameters, and often fail under conflicting modalities or mismatched latent spaces, limiting their ability to perform synergistic fusion across semantic and spatial domains. We introduce MMFace-DiT, a unified dual-stream diffusion transformer engineered for synergistic multimodal face synthesis. Its core novelty lies in a dual-stream transformer block that processes spatial (mask/sketch) and semantic (text) tokens in parallel, deeply fusing them through a shared Rotary Position-Embedded (RoPE) Attention mechanism. This design prevents modal dominance and ensures strong adherence to both text and structural priors to achieve unprecedented spatial-semantic consistency for controllable face generation. Furthermore, a novel Modality Embedder enables a single cohesive model to dynamically adapt to varying spatial conditions without retraining. MMFace-DiT achieves a 40% improvement in visual fidelity and prompt alignment over six state-of-the-art multimodal face generation models, establishing a flexible new paradigm for end-to-end controllable generative modeling. The code and dataset are available on our project page: https://vcbsl.github.io/MMFace-DiT/

Recent advances in diffusion-based controllable visual generation have led to remarkable improvements in image quality. However, these powerful models are typically deployed on cloud servers due to their large computational demands, raising serious concerns about user data privacy. To enable secure and efficient on-device generation, we explore in this paper controllable diffusion models built upon linear attention architectures, which offer superior scalability and efficiency, even on edge devices. Yet, our experiments reveal that existing controllable generation frameworks, such as ControlNet and OminiControl, either lack the flexibility to support multiple heterogeneous condition types or suffer from slow convergence on such linear-attention models. To address these limitations, we propose a novel controllable diffusion framework tailored for linear attention backbones like SANA. The core of our method lies in a unified gated conditioning module working in a dual-path pipeline, which effectively integrates multi-type conditional inputs, such as spatially aligned and non-aligned cues. Extensive experiments on multiple tasks and benchmarks demonstrate that our approach achieves state-of-the-art controllable generation performance based on linear-attention models, surpassing existing methods in terms of fidelity and controllability.

Autoregressive (AR) vision-language models (VLMs) have long dominated multimodal understanding, reasoning, and graphical user interface (GUI) grounding. Recently, discrete diffusion vision-language models (DVLMs) have shown strong performance in multimodal reasoning, offering bidirectional attention, parallel token generation, and iterative refinement. However, their potential for GUI grounding remains unexplored. In this work, we evaluate whether discrete DVLMs can serve as a viable alternative to AR models for GUI grounding. We adapt LLaDA-V for single-turn action and bounding-box prediction, framing the task as text generation from multimodal input. To better capture the hierarchical structure of bounding-box geometry, we propose a hybrid masking schedule that combines linear and deterministic masking, improving grounding accuracy by up to 6.1 points in Step Success Rate (SSR) over the GUI-adapted LLaDA-V trained with linear masking. Evaluations on four datasets spanning web, desktop, and mobile interfaces show that the adapted diffusion model with hybrid masking consistently outperforms the linear-masked variant and performs competitively with autoregressive counterparts despite limited pretraining. Systematic ablations reveal that increasing diffusion steps, generation length, and block length improves accuracy but also increases latency, with accuracy plateauing beyond a certain number of diffusion steps. Expanding the training data with diverse GUI domains further reduces latency by about 1.3 seconds and improves grounding accuracy by an average of 20 points across benchmarks. These results demonstrate that discrete DVLMs are a promising modeling framework for GUI grounding and represent an important step toward diffusion-based GUI agents.

Accurate survival prediction from multimodal medical data is essential for precision oncology, yet clinical deployment faces a persistent challenge: modalities are frequently incomplete due to cost constraints, technical limitations, or retrospective data availability. While recent methods attempt to address missing modalities through feature alignment or joint distribution learning, they fundamentally lack explicit modeling of the unique contributions of each modality as opposed to the information derivable from other modalities. We propose MUST (Modality-Specific representation-aware Transformer), a novel framework that explicitly decomposes each modality's representation into modality-specific and cross-modal contextualized components through algebraic constraints in a learned low-rank shared subspace. This decomposition enables precise identification of what information is lost when a modality is absent. For the truly modality-specific information that cannot be inferred from available modalities, we employ conditional latent diffusion models to generate high-quality representations conditioned on recovered shared information and learned structural priors. Extensive experiments on five TCGA cancer datasets demonstrate that MUST achieves state-of-the-art performance with complete data while maintaining robust predictions in both missing pathology and missing genomics conditions, with clinically acceptable inference latency.

Multimodal Diffusion Large Language Models (MDLLMs) achieve high-concurrency generation through parallel masked decoding, yet the architectures remain prone to multimodal hallucinations. This structural vulnerability stems from an algorithmic flaw: the decoder ranks candidate tokens based on textual likelihood without verifying localized visual support. We establish that this language-only ranking induces an objective mismatch, where language probability mass acts as a misspecified proxy for the intended multimodal task. Consequently, we reinterpret hallucination as a localized optimization error, a phenomenon where the decoder exploits language shortcuts to maximize a proxy score at the expense of visual grounding. To address this objective mismatch, we introduce VISAGE, a training-free decoding framework that calibrates the objective at inference time. VISAGE estimates the proxy discrepancy by quantifying the spatial entropy of cross-attention distributions. By enforcing a localization consensus across attention heads, the method penalizes spatially uniform distributions and re-ranks token commitments to favor visually grounded outcomes. We provide an analytical stability guarantee establishing that VISAGE maintains a bounded objective loss under estimation error. Evaluations across hallucination-sensitive and general-purpose benchmarks demonstrate the robustness of the framework, yielding relative gains of 8.59% on MMMU-val and 7.75% on HallusionBench.

Recent advances in Virtual Try-On (VTON) and Virtual Try-Off (VTOFF) have greatly improved photo-realistic fashion synthesis and garment reconstruction. However, existing datasets remain static, lacking instruction-driven editing for controllable and interactive fashion generation. In this work, we introduce the Dress Editing Dataset (Dress-ED), the first large-scale benchmark that unifies VTON, VTOFF, and text-guided garment editing within a single framework. Each sample in Dress-ED includes an in-shop garment image, the corresponding person image wearing the garment, their edited counterparts, and a natural-language instruction of the desired modification. Built through a fully automated multimodal pipeline that integrates MLLM-based garment understanding, diffusion-based editing, and LLM-guided verification, Dress-ED comprises over 146k verified quadruplets spanning three garment categories and seven edit types, including both appearance (e.g., color, pattern, material) and structural (e.g., sleeve length, neckline) modifications. Based on this benchmark, we further propose a unified multimodal diffusion framework that jointly reasons over linguistic instructions and visual garment cues, serving as a strong baseline for instruction-driven VTON and VTOFF. Dataset and code available at this link: https://github.com/aimagelab/Dress-ED

Diffusion probabilistic models have demonstrated significant potential in generating high-quality, realistic medical images, providing a promising solution to the persistent challenge of data scarcity in the medical field. Nevertheless, producing 3D medical volumes with anatomically consistent structures under multimodal conditions remains a complex and unresolved problem. We introduce Sketch2CT, a multimodal diffusion framework for structure-aware 3D medical volume generation, jointly guided by a user-provided 2D sketch and a textual description that captures 3D geometric semantics. The framework initially generates 3D segmentation masks of the target organ from random noise, conditioned on both modalities. To effectively align and fuse these inputs, we propose two key modules that refine sketch features with localized textual cues and integrate global sketch-text representations. Built upon a capsule-attention backbone, these modules leverage the complementary strengths of sketches and text to produce anatomically accurate organ shapes. The synthesized segmentation masks subsequently guide a latent diffusion model for 3D CT volume synthesis, enabling realistic reconstruction of organ appearances that are consistent with user-defined sketches and descriptions. Extensive experiments on public CT datasets demonstrate that Sketch2CT achieves superior performance in generating multimodal medical volumes. Its controllable, low-cost generation pipeline enables principled, efficient augmentation of medical datasets. Code is available at https://github.com/adlsn/Sketch2CT.

The dual-stream transformer architecture-based joint audio-video generation method has become the dominant paradigm in current research. By incorporating pre-trained video diffusion models and audio diffusion models, along with a cross-modal interaction attention module, high-quality, temporally synchronized audio-video content can be generated with minimal training data. In this paper, we first revisit the dual-stream transformer paradigm and further analyze its limitations, including model manifold variations caused by the gating mechanism controlling cross-modal interactions, biases in multi-modal background regions introduced by cross-modal attention, and the inconsistencies in multi-modal classifier-free guidance (CFG) during training and inference, as well as conflicts between multiple conditions. To alleviate these issues, we propose Cross-Modal Context Learning (CCL), equipped with several carefully designed modules. Temporally Aligned RoPE and Partitioning (TARP) effectively enhances the temporal alignment between audio latent and video latent representations. The Learnable Context Tokens (LCT) and Dynamic Context Routing (DCR) in the Cross-Modal Context Attention (CCA) module provide stable unconditional anchors for cross-modal information, while dynamically routing based on different training tasks, further enhancing the model's convergence speed and generation quality. During inference, Unconditional Context Guidance (UCG) leverages the unconditional support provided by LCT to facilitate different forms of CFG, improving train-inference consistency and further alleviating conflicts. Through comprehensive evaluations, CCL achieves state-of-the-art performance compared with recent academic methods while requiring substantially fewer resources.

The protein folding problem has been fundamentally transformed by artificial intelligence, evolving from static structure prediction toward the modeling of dynamic conformational ensembles and complex biomolecular interactions. This review systematically examines the paradigm shift in AI driven protein science across five interconnected dimensions: unified multimodal representations that integrate sequences, geometries, and textual knowledge; refinement of static prediction through MSA free architectures and all atom complex modeling; generative frameworks, including diffusion models and flow matching, that capture conformational distributions consistent with thermodynamic ensembles; prediction of heterogeneous interactions spanning protein ligand, protein nucleic acid, and protein protein complexes; and functional inference of fitness landscapes, mutational effects, and text guided property prediction. We critically analyze current bottlenecks, including data distribution biases, limited mechanistic interpretability, and the disconnect between geometric metrics and biophysical reality, while identifying future directions toward physically consistent generative models, multimodal foundation architectures, and experimental closed loop systems. This methodological transformation marks artificial intelligence's transition from a structural analysis tool into a universal simulator capable of understanding and ultimately rewriting the dynamic language of life.

We present a method for generating physically-based materials for 3D shapes based on a video diffusion transformer architecture. Our method is conditioned on input geometry and a text description, and jointly models multiple material properties (base color, roughness, metallicity, height map) to form physically plausible materials. We further introduce a custom variational auto-encoder which encodes multiple material modalities into a compact latent space, which enables joint generation of multiple modalities without increasing the number of tokens. Our pipeline generates high-quality materials for 3D shapes given a text prompt, compatible with common content creation tools.

Multimodal generative models have shown remarkable progress in single-modality video and audio synthesis, yet truly joint audio-video generation remains an open challenge. In this paper, I explore four key contributions to advance this field. First, I release two high-quality, paired audio-video datasets. The datasets consisting on 13 hours of video-game clips and 64 hours of concert performances, each segmented into consistent 34-second samples to facilitate reproducible research. Second, I train the MM-Diffusion architecture from scratch on our datasets, demonstrating its ability to produce semantically coherent audio-video pairs and quantitatively evaluating alignment on rapid actions and musical cues. Third, I investigate joint latent diffusion by leveraging pretrained video and audio encoder-decoders, uncovering challenges and inconsistencies in the multimodal decoding stage. Finally, I propose a sequential two-step text-to-audio-video generation pipeline: first generating video, then conditioning on both the video output and the original prompt to synthesize temporally synchronized audio. My experiments show that this modular approach yields high-fidelity generations of audio video generation.

Lung cancer remains the leading cause of cancer-related mortality worldwide, with survival outcomes critically dependent on early and accurate detection. When low-dose computed tomography (LDCT) findings are indeterminate, clinicians typically defer diagnosis pending follow-up CT imaging obtained up to 12 months later, inevitably delaying treatment for patients with malignant nodules. To address this clinical gap, we propose Nodule-Aligned Multimodal (Latent) Diffusion (NAMD), a novel generative framework that synthesizes one-year follow-up nodule CT images conditioned on the baseline CT scan, quantitative nodule biomarkers, and patient-level Electronic Health Records (EHR), enabling timely prediction of nodule malignant progression without requiring actual follow-up scans. NAMD introduces two key contributions: (i) a nodule-aligned latent space regularized so that embedding distances reflect clinically meaningful biomarker changes, and (ii) an LLM-driven multimodal conditioning mechanism encoding heterogeneous EHR data into the diffusion backbone. Evaluated on the National Lung Screening Trial (NLST), our method's synthetic follow-up images achieve an AUROC of 0.805 and an AUPRC of 0.346 for lung nodule malignancy prediction, outperforming both the baseline LDCT performance without virtual follow-up generation, and existing state-of-the-art conditional generation methods, while maintaining competitive image quality. These findings suggest that NAMD enables earlier and more accurate lung cancer diagnosis by capturing clinically meaningful features of nodule progression.

Scene Text Image Super-Resolution (STISR) aims to restore high-resolution details in low-resolution text images, which is crucial for both human readability and machine recognition. Existing methods, however, often depend on external Optical Character Recognition (OCR) models for textual priors or rely on complex multi-component architectures that are difficult to train and reproduce. In this paper, we introduce DualTSR, a unified end-to-end framework that addresses both issues. DualTSR employs a single multimodal transformer backbone trained with a dual diffusion objective. It simultaneously models the continuous distribution of high-resolution images via Conditional Flow Matching and the discrete distribution of textual content via discrete diffusion. This shared design enables visual and textual information to interact at every layer, allowing the model to infer text priors internally instead of relying on an external OCR module. Compared with prior multi-branch diffusion systems, DualTSR offers a simpler end-to-end formulation with fewer hand-crafted components. Experiments on synthetic Chinese benchmarks and a curated real-world evaluation protocol show that DualTSR achieves strong perceptual quality and text fidelity.

Text-guided 3D motion editing has seen success in single-person scenarios, but its extension to multi-person settings is less explored due to limited paired data and the complexity of inter-person interactions. We introduce the task of multi-person 3D motion editing, where a target motion is generated from a source and a text instruction. To support this, we propose InterEdit3D, a new dataset with manual two-person motion change annotations, and a Text-guided Multi-human Motion Editing (TMME) benchmark. We present InterEdit, a synchronized classifier-free conditional diffusion model for TMME. It introduces Semantic-Aware Plan Token Alignment with learnable tokens to capture high-level interaction cues and an Interaction-Aware Frequency Token Alignment strategy using DCT and energy pooling to model periodic motion dynamics. Experiments show that InterEdit improves text-to-motion consistency and edit fidelity, achieving state-of-the-art TMME performance. The dataset and code will be released at https://github.com/YNG916/InterEdit.

Deep generative models offer a powerful alternative to conventional channel estimation by learning complex channel distributions. By integrating the rich environmental information available in modern sensing-aided networks, this paper proposes MultiCE-Flow, a multimodal channel estimation framework based on flow matching and diffusion transformer (DiT). We design a specialized multimodal perception module that fuses LiDAR, camera, and location data into a semantic condition, while treating sparse pilots as a structural condition. These conditions guide a DiT backbone to reconstruct high-fidelity channels. Unlike standard diffusion models, we employ flow matching to learn a linear trajectory from noise to data, enabling efficient one-step sampling. By leveraging environmental semantics, our method mitigates the ill-posed nature of estimation with sparse pilots. Extensive experiments demonstrate that MultiCE-Flow consistently outperforms traditional baselines and existing generative models. Notably, it exhibits superior robustness to out-of-distribution scenarios and varying pilot densities, making it suitable for environment-aware communication systems.

Page-level calligraphy synthesis requires balancing glyph precision with layout composition. Existing character models lack spatial context, while page-level methods often compromise brushwork detail. In this paper, we present CalliMaster, a unified framework for controllable generation and editing that resolves this conflict by decoupling spatial planning from content synthesis. Inspired by the human cognitive process of ``planning before writing'', we introduce a coarse-to-fine pipeline \textbf{(Text $\rightarrow$ Layout $\rightarrow$ Image)} to tackle the combinatorial complexity of page-scale synthesis. Operating within a single Multimodal Diffusion Transformer, a spatial planning stage first predicts character bounding boxes to establish the global spatial arrangement. This intermediate layout then serves as a geometric prompt for the content synthesis stage, where the same network utilizes flow-matching to render high-fidelity brushwork. Beyond achieving state-of-the-art generation quality, this disentanglement supports versatile downstream capabilities. By treating the layout as a modifiable constraint, CalliMaster enables controllable semantic re-planning: users can resize or reposition characters while the model automatically harmonizes the surrounding void space and brush momentum. Furthermore, we demonstrate the framework's extensibility to artifact restoration and forensic analysis, providing a comprehensive tool for digital cultural heritage.

Controllable pathology image synthesis requires reliable regulation of spatial layout, tissue morphology, and semantic detail. However, existing text-guided diffusion models offer only coarse global control and lack the ability to enforce fine-grained structural constraints. Progress is further limited by the absence of large datasets that pair patch-level spatial layouts with detailed diagnostic descriptions, since generating such annotations for gigapixel whole-slide images is prohibitively time-consuming for human experts. To overcome these challenges, we first develop a scalable multi-agent LVLM annotation framework that integrates image description, diagnostic step extraction, and automatic quality judgment into a coordinated pipeline, and we evaluate the reliability of the system through a human verification process. This framework enables efficient construction of fine-grained and clinically aligned supervision at scale. Building on the curated data, we propose In-Context Diffusion Transformer (IC-DiT), a layout-aware generative model that incorporates spatial layouts, textual descriptions, and visual embeddings into a unified diffusion transformer. Through hierarchical multimodal attention, IC-DiT maintains global semantic coherence while accurately preserving structural and morphological details. Extensive experiments on five histopathology datasets show that IC-DiT achieves higher fidelity, stronger spatial controllability, and better diagnostic consistency than existing methods. In addition, the generated images serve as effective data augmentation resources for downstream tasks such as cancer classification and survival analysis.

Multimodal neuroimaging provides complementary insights for Alzheimer's disease diagnosis, yet clinical datasets frequently suffer from missing modalities. We propose ACADiff, a framework that synthesizes missing brain imaging modalities through adaptive clinical-aware diffusion. ACADiff learns mappings between incomplete multimodal observations and target modalities by progressively denoising latent representations while attending to available imaging data and clinical metadata. The framework employs adaptive fusion that dynamically reconfigures based on input availability, coupled with semantic clinical guidance via GPT-4o-encoded prompts. Three specialized generators enable bidirectional synthesis among sMRI, FDG-PET, and AV45-PET. Evaluated on ADNI subjects, ACADiff achieves superior generation quality and maintains robust diagnostic performance even under extreme 80% missing scenarios, outperforming all existing baselines. To promote reproducibility, code is available at https://github.com/rongzhou7/ACADiff

Recent advances in text-to-image generation have been remarkable, but generating multilingual design logos that harmoniously integrate visual and textual elements remains a challenging task. Existing methods often distort character geometry when applying creative styles and struggle to support multilingual text generation without additional training. To address these challenges, we propose LogoDiffuser, a training-free method that synthesizes multilingual logo designs using the multimodal diffusion transformer. Instead of using textual prompts, we input the target characters as images, enabling robust character structure control regardless of language. We first analyze the joint attention mechanism to identify core tokens, which are tokens that strongly respond to textual structures. With this observation, our method integrates character structure and visual design by injecting the most informative attention maps. Furthermore, we perform layer-wise aggregation of attention maps to mitigate attention shifts across layers and obtain consistent core tokens. Extensive experiments and user studies demonstrate that our method achieves state-of-the-art performance in multilingual logo generation.

Multimodal medical image fusion facilitates comprehensive diagnosis by aggregating complementary structural and functional information, but its effectiveness is limited by resolution degradation and modality discrepancies. Existing approaches typically perform image fusion and super-resolution (SR) in separate stages, leading to artifacts and degraded perceptual quality. These limitations are further amplified in tri-modal settings that combine anatomical modalities (e.g., MRI, CT) with functional scans (e.g., PET, SPECT) due to pronounced frequency domain imbalances. We propose TriFusionSR, a wavelet-guided conditional diffusion framework for joint tri-modal fusion and SR. The framework explicitly decomposes multimodal features into frequency bands using the 2D Discrete Wavelet Transform, enabling frequency-aware crossmodal interaction. We further introduce a Rectified Wavelet Features (RWF) strategy for latent coefficient calibration, followed by an Adaptive Spatial-Frequency Fusion (ASFF) module with gated channel-spatial attention to enable structure-driven multimodal refinement. Extensive experiments demonstrate state-of-the-art performance, achieving 4.8-12.4% PSNR improvement and substantial reductions in RMSE and LPIPS across multiple upsampling scales.

While recent multimodal large language models (MLLMs) have made impressive strides, they predominantly employ a conventional autoregressive architecture as their backbone, leaving significant room to explore effective and efficient alternatives in architectural design. Concurrently, recent studies have successfully applied discrete diffusion models to various domains, such as visual understanding and image generation, revealing their considerable potential as a promising backbone for multimodal systems. Drawing inspiration from these pioneering studies, we introduce Omni-Diffusion, the first any-to-any multimodal language model built entirely on mask-based discrete diffusion models, which unifies understanding and generation across text, speech, and images. Omni-Diffusion employs a unified mask-based discrete diffusion model to directly capture the joint distribution over discrete multimodal tokens. This approach supports not only bimodal tasks but also more complex scenarios involving multiple modalities. On a diverse set of benchmarks, our method outperforms or performs on par with existing multimodal systems that process two or more modalities, highlighting the significant promise of diffusion models in powering the next generation of multimodal foundation models. Project webpage: https://omni-diffusion.github.io.

While diffusion models have revolutionized visual content generation, their rapid adoption has underscored the critical need to investigate vulnerabilities, e.g., to backdoor attacks. In multimodal diffusion models, it is natural to expect that attacking multiple modalities simultaneously (e.g., text and image) would yield complementary effects and strengthen the overall backdoor. In this paper, we challenge this assumption by investigating the phenomenon of Backdoor Modality Collapse, a scenario where the backdoor mechanism degenerates to rely predominantly on a subset of modalities, rendering others redundant. To rigorously quantify this behavior, we introduce two novel metrics: Trigger Modality Attribution (TMA) and Cross-Trigger Interaction (CTI). Through extensive experiments across diverse training configurations in multimodal conditional diffusion, we consistently observe a ``winner-takes-all'' dynamic in backdoor behavior. Our results reveal that (1) attacks often collapse into subset-modality dominance, and (2) cross-modal interaction is negligible or even negative, contradicting the intuition of synergistic vulnerability. These findings highlight a critical blind spot in current assessments, suggesting that high attack success rates often mask a fundamental reliance on a subset of modalities. This establishes a principled foundation for mechanistic analysis and future defense development.

Generating high-fidelity 3D avatars from text or image prompts is highly sought after in virtual reality and human-computer interaction. However, existing text-driven methods often rely on iterative Score Distillation Sampling (SDS) or CLIP optimization, which struggle with fine-grained semantic control and suffer from excessively slow inference. Meanwhile, image-driven approaches are severely bottlenecked by the scarcity and high acquisition cost of high-quality 3D facial scans, limiting model generalization. To address these challenges, we first construct a novel, large-scale dataset comprising over 100,000 pairs across four modalities: fine-grained textual descriptions, in-the-wild face images, high-quality light-normalized texture UV maps, and 3D geometric shapes. Leveraging this comprehensive dataset, we propose PromptAvatar, a framework featuring dual diffusion models. Specifically, it integrates a Texture Diffusion Model (TDM) that supports flexible multi-condition guidance from text and/or image prompts, alongside a Geometry Diffusion Model (GDM) guided by text prompts. By learning the direct mapping from multi-modal prompts to 3D representations, PromptAvatar eliminates the need for time-consuming iterative optimization, successfully generating high-fidelity, shading-free 3D avatars in under 10 seconds. Extensive quantitative and qualitative experiments demonstrate that our method significantly outperforms existing state-of-the-art approaches in generation quality, fine-grained detail alignment, and computational efficiency.

Multi-modal remote sensing imagery provides complementary observations of the same geographic scene, yet such observations are frequently incomplete in practice. Existing cross-modal translation methods treat each modality pair as an independent task, resulting in quadratic complexity and limited generalization to unseen modality combinations. We formulate Any-to-Any translation as inference over a shared latent representation of the scene, where different modalities correspond to partial observations of the same underlying semantics. Based on this formulation, we propose Any2Any, a unified latent diffusion framework that projects heterogeneous inputs into a geometrically aligned latent space. Such structure performs anchored latent regression with a shared backbone, decoupling modality-specific representation learning from semantic mapping. Moreover, lightweight target-specific residual adapters are used to correct systematic latent mismatches without increasing inference complexity. To support learning under sparse but connected supervision, we introduce RST-1M, the first million-scale remote sensing dataset with paired observations across five sensing modalities, providing supervision anchors for any-to-any translation. Experiments across 14 translation tasks show that Any2Any consistently outperforms pairwise translation methods and exhibits strong zero-shot generalization to unseen modality pairs. Code and models are available at https://github.com/MiliLab/Any2Any.