Synagent

Self-driving laboratories can explore synthesis conditions autonomously, but their decision-making layer is typically a black-box optimizer, and the output is a set of optimized samples, with the measurements reduced to predefined scalar objectives and the reasons behind success left unarticulated. Here we present SynAgent, a framework in which large language model agents operate an automated experimental system and maintain an explicit, revisable understanding of the synthesis process as the campaign's primary output. Starting with no predefined analysis pipeline, SynAgent adaptively generates analysis skills for newly acquired data and evolves this understanding through multimodal reasoning over experimental data such as X-ray diffraction patterns and electron micrographs. The evolution is guided by a verify-falsify scheme, in which the agent deliberately challenges its own hypotheses by testing conditions predicted to fail as well as those predicted to succeed. In a single campaign of 18 autonomous experiments using LiCoO2 (001) thin-film deposition as a testbed, SynAgent synthesized highly crystalline films and evolved an understanding of how the substrate temperature governs crystallization, discovering an abrupt threshold and a narrow optimal growth window at 650-690 °C. These results extend autonomous experimentation beyond optimized samples to testable, human-readable understanding.

In proton therapy, plans are typically optimized on a single planning CT, making robustness evaluation essential under anatomical changes. However, current scenarios often rely on simplified perturbations that poorly capture complex, patient-specific variability. We propose SynthRCT, a scalable conditional generative framework for 3D anatomical deformation synthesis. Based on a conditional variational autoencoder, SynthRCT learns a latent deformation space and decodes sampled latent codes into local stationary velocity fields conditioned on an input anatomy. Local fields are assembled into coherent full-volume transformations, enabling memory-scalable generation for large field-of-view CT data. We validate the approach on respiratory 4DCT data with multiple breathing-phase anatomies per subject. SynthRCT enables patient-specific sampling of plausible anatomical transformations beyond predefined robustness scenarios. Code available at: https://github.com/TomasGuija/SynthRCT.

Logic synthesis transforms RTL designs into gate-level netlists, where PPA results are highly sensitive to the choice of optimization commands, making synthesis tuning both high-dimensional and expensive. Previous approaches fall into two categories: automated methods, which perform black-box search over fixed action spaces with limited decision-level interpretability, and LLM-based methods, which typically generate static scripts upfront and cannot adapt to evolving circuit states. We present SynAct, an adaptive closed-loop LLM reasoning--acting agent that iteratively diagnoses live synthesis reports and reasons over the current circuit state, retrieved tool knowledge, and historical optimization experience to issue targeted commands. SynAct focuses on improving timing, particularly worst negative slack (WNS), while maintaining balanced area and power trade-offs. Experiments on a commercial synthesis tool across 14 designs show that SynAct reduces average WNS to 27% of that from bootstrap synthesis.

VAR has gained widespread popularity due to its next-scale prediction paradigm. However, it faces substantial performance bottlenecks when handling complex scenes with multiple objects and attributes. Existing diffusion-based enhancement methods fail to adequately address the unique challenge of cross-scale error propagation and accumulation in VAR. To this end, we propose SynVAR, the first training-free enhancement framework specifically tailored for the VAR paradigm, which introduces a spatial-semantic collaborative control strategy to effectively suppress propagation error and improve generation quality. SynVAR comprises three key components: (1) Global guidance to ensure reasonable spatial structure in the early stages, (2) Receptive field constraints to mitigate early-stage semantic confusion, (3) High-frequency compensation to recover fine-grained details. Extensive quantitative and qualitative experiments demonstrate the significant improvements in the ability of SynVAR to enhance the VAR's capability for complex scene modeling.

Chain-of-thought (CoT) prompting can fail severely on constraint-dense logical reasoning tasks, where unverified errors accumulate silently across steps. We introduce SymStep: an LLM makes one atomic claim at a time (DEDUCE: Alice, pet, Cat), then a lightweight constraint propagator checks the claim for consistency with prior accepted deductions, rejects contradictions, and cascades implied facts automatically. SymStep+G additionally provides MRV guidance after each accepted step, directing the LLM toward the most constrained unresolved variable. On a 35-puzzle retained subset of ZebraLogicBench, a benchmark of 1,000 Einstein-style logic puzzles, Direct and CoT both achieve 0%, while SymStep+G reaches 97%. On AR-LSAT analytical reasoning problems, SymStep achieves 100% vs. CoT's 87%. On LGP-14, SymStep+G achieves 100% vs. 0% for CoT and Logic-LM, the strongest prior symbolic+LLM baseline we compare against. Ablation studies reveal that MRV guidance is a key mechanism for reducing directionless cycling, while consistency checking provides a safety net against explicit contradictions. Across six benchmarks spanning five task domains, SymStep variants match or exceed every baseline on constraint-dense and arithmetic tasks. Experiments on AQUA-RAT algebra confirm the advantage is constraint-density-specific.

Federated learning (FL) offers a promising approach to privacy-preserving clinical risk prediction, but its deployment remains limited by restricted data sharing, client heterogeneity, class imbalance, and the lack of realistic tabular electronic health record (EHR) benchmarks. Synthetic data generation may alleviate data scarcity, yet its integration with federated optimisation has received limited systematic study. We propose SynPre-FL, a unified framework combining high-fidelity synthetic EHR generation with synthetic-pretrained FL for robust prediction under non-IID conditions. A latent autoencoder-diffusion model generates privacy-preserving synthetic cohorts, which are used to warm-start federated training. This pretraining is followed by heterogeneity-aware optimisation using class-balanced local objectives, proximal regularisation, and adaptive server aggregation. Post-hoc calibration and federated-safe explainability support reliable and interpretable risk estimates. Experiments show that the synthetic generator preserves univariate, bivariate, and multivariate structure while protecting against membership-inference and reconstruction attacks. The generated data achieve strong downstream utility under TSTR, TRTS, and model-based evaluations. Across federated settings with 5, 10, and 15 heterogeneous clients, SynPre-FL consistently improves robustness and scalability over baseline methods, especially under severe non-IID fragmentation. Calibration improves probability reliability, while SHAP analysis produces stable and clinically coherent feature attributions across federation sizes. SynPre-FL therefore provides a practical and reproducible framework for combining synthetic data with FL to enable privacy-aware, interpretable, and robust clinical prediction from distributed tabular EHR data.

Open-vocabulary dense perception (OVDP) aims to localize objects unseen during training by leveraging textual knowledge. Despite the remarkable progress of recent CLIP-based approaches, we identify a critical limitation: synonym-induced grounding inconsistency, where semantically equivalent expressions yield disparate spatial attention patterns. This inconsistency undermines the robustness and performance of existing methods in real-world OVDP applications. To address this issue, we propose SynCLIP, a Synonym-Coherent Language-Image Pretraining framework that enhances synonym-robust grounding for OVDP. SynCLIP introduces a Semantic-consistent Spatial Attention alignment (SSA) module to enhance spatial attention consistency by minimizing discrepancies between attention maps of original and synonymous expressions. Furthermore, a Spatial Attention Refinement (SAR) module selectively strengthens the most semantically relevant spatial regions within aligned maps for more precise and stable grounding. To support synonym-coherent pretraining, we also construct a Synonym-Enriched Visual Corpus (SEViC), which augments each category with multiple synonyms and textual definitions. Extensive experiments on multiple benchmarks demonstrate that SynCLIP substantially improves grounding consistency under diverse linguistic variants and achieves state-of-the-art performance among CLIP-based OVDP methods. Code is available at https://github.com/Justlovesmile/SynCLIP.

In this study, we present a large-scale descriptive analysis of the use of an AI-based learning assistant (Syntea) in higher education. Based on objective log data from 77,543 students enrolled in distance studies, we examine usage patterns across gender, age group, study cluster, degree, and study mode. To date, existing research on educational chatbots has largely relied on comparatively small samples and self-reported survey data, while large-scale evidence on actual usage behavior remains limited. Our findings show that Syntea is already embedded in the study routines of many learners, but that usage differs across demographic and structural contexts. By identifying these patterns, our study provides an empirical basis for the further development of AI-based learning support and contributes a large-scale analysis of educational chatbot usage in higher education.

We present SynLaD, a latent diffusion framework for small-molecule generation that unifies ligand-based drug design objectives (what to make) with synthetic accessibility (how to make it). Current models typically optimize one objective at the expense of the other, creating a bottleneck for discovering high-scoring and synthesizable molecules. SynLaD combines reaction-constrained generation with pharmacophore-conditioned 3D design by learning a latent space that decodes to both 3D structures and synthesis pathways. An encoder maps molecules to a latent representation used by two decoder heads: (i) a geometric head that reconstructs atom types and coordinates and (ii) an autoregressive synthesis head that outputs synthetic routes in a serialized, reaction-based notation. A diffusion transformer generates novel latents in the learned space, conditioned on pharmacophore profiles. Across analogue generation tasks for bioactive ligands, SynLaD outperforms existing baselines in synthesizable and diverse hit generation, demonstrating that a single model can produce shape-aligned molecules with feasible synthesis plans.

Human hand-object interactions encode functional intent, but direct transfer to robotic hands often fails under morphology, contact, and reachability constraints. We present SynManDex, a synthetic pipeline that uses generated human pre-grasps as affordance-aware proposals and resolves the final contacts with robot-native optimization. SynManDex samples object-conditioned digital human pre-grasps, retargets them to dexterous robotic hand poses, optimizes force-closure contacts on the target embodiment, and admits trajectories that pass checks from each step. The resulting keyframes support both grasp-and-lift demonstrations and various prehensile manipulation tasks such as tea pouring, photo taking, and flute playing, designed via VLM agents. As a result, SynManDex combines high grasp quality (86.4% grasp stability) with 4.67/5 human-likeness (93.4%). It achieves 80.7% successes in simulation and 25/30 (83.3%) real-robot successes when applied to a 36-DOF bimanual dexterous robotic platform.

Large language models (LLMs) have been widely adopted for synthetic data generation, significantly reducing annotation costs. However, most existing studies treat synthesis as a set of isolated tasks and overlook a more fundamental question: whether a model can learn to synthesize by accumulating experience from past tasks and transferring it to future ones. In this work, we introduce StreamSynth, a new setting in which synthesis tasks arrive sequentially and experience from historical tasks provides informative signals for future synthesis. To address this setting, we propose SynLearner, a general framework that enables synthesis models to acquire reusable synthesis experience over a task stream. Instead of generating data independently for each task, SynLearner encourages the model to explore diverse synthesis patterns, learn from feedback, and balance sample quality with set-level diversity as tasks evolve. Extensive experiments across multiple benchmarks show that SynLearner effectively leverages experience from earlier tasks to improve synthesis performance on later ones, exhibiting consistent cross-task transferability. These findings provide evidence for the feasibility of StreamSynth and highlight synthetic data generation as an experience-driven process that can benefit from task streams.

Machine learning (ML) is increasingly used for data-driven modeling of buildings to enable downstream tasks such as fault detection and diagnosis, and energy-efficient control. While recent work improves generalization across building characteristics, weather, and occupancy, generalization also depends on sufficient exploration of the control-driven system state space. Existing real-world datasets and simulation environments predominantly reflect stationary operation under fixed control policies, resulting in limited excitation and reduced robustness to unseen operating conditions. This paper introduces BuilDyn, a package based on BuilDa that enables customizable excitation strategies for control-oriented data generation. BuilDyn further supports sampling from representative building distributions and provides a Python interface for easy integration into machine learning pipelines. We demonstrate the benefits of BuilDyn by comparing the performance of data-driven ML models trained on non-excited and excited data for one building. With BuilDyn, we hope to advance scalable control-oriented modeling and support future directions such as transfer learning and building-specific foundation models.

Purpose: Laparoscopic ultrasound (LUS) enhances the safety of liver surgery by visualizing intrahepatic vessels in real-time. Still, vessel identification remains difficult due to probe constraints, complex vascular structure, and tissue deformation. This work aims to enable real-time, patient-specific vessel identification that remains robust under deformation through deformable ultrasound augmentation. Methods: Preoperative CT vessel annotations are used to generate synthetic ultrasound data via optimized physics-based rendering, coupled with domain adaptation to intraoperative ultrasound. The rendering is trained end-to-end for vessel identification and patient-specificity, eliminating the need for preoperative ultrasound. A deformation-aware augmentation simulates realistic intraoperative motion and tissue deformation within the rendering pipeline. Results: In abdominal phantom and limited clinical feasibility experiments (single-case clinical evaluation), the framework achieved real-time intrahepatic vessel-branch identification, maintaining performance under new patient poses. Conclusion: The framework enables real-time vessel identification without preoperative ultrasound and supports technical feasibility, but multi-patient validation is still needed for generalizability and clinical feasibility.

The growing complexity of quantum programming frameworks has exposed a critical limitation in existing large language model (LLM)-based code assistants: general-purpose models hallucinate PennyLane-specific gate names, misplace device configurations, and produce structurally invalid circuits when faced with specialized quantum coding challenges. We present PennySynth, a retrieval-augmented generation framework that addresses this gap by conditioning LLM inference on a curated knowledge base of 13,389 PennyLane instruction-code pairs, built via a three-stage extraction, verification, and deduplication pipeline over official PennyLane repositories, community GitHub sources, and QHack competition archives. PennySynth introduces a code-aware embedding strategy using st-codesearch-distilroberta-base, trained for natural-language-to-code retrieval, increasing average retrieval cosine similarity from 0.45 to 0.726 compared to a general-purpose baseline. Evaluated across 74 challenges spanning three years of the QHack competition (2022, 2023, 2024), PennySynth achieves 64%, 68%, and 52% pass@5 on QHack 2022, 2023, and 2024, respectively, improving over Claude Sonnet 4.6 without retrieval by +28, +25, and +28 percentage points. We further introduce a quantum-adapted CodeBLEU metric that upweights qml.* token patterns and show that structural code similarity and functional correctness capture distinct aspects of quantum code quality. Controlled ablations reveal that code-aware embeddings are the primary driver of retrieval performance, while dataset expansion and source composition provide additional gains when retrieval quality is sufficiently precise.

Generative Recommendation (GR) has emerged as a promising paradigm by formulating item recommendation as a sequence-to-sequence generation task over item identifiers. Recent studies have incorporated multimodal signals to provide richer token-level evidence for generation. However, existing approaches largely rely on alignment-centric fusion and underexplore synergistic information across modalities. In practice, synergistic information plays a critical role in capturing emergent item properties that cannot be inferred from any single modality alone. Such properties encode intrinsic item semantics and guide user preferences, enabling models to move beyond surface-level feature matching. To address this limitation, we propose \textbf{SynGR}, a synergistic generative recommendation framework that explicitly encourages the exploitation of cross-modal dependencies during generation. By constraining overreliance on dominant modalities, SynGR enables the model to capture emergent item semantics beyond shared or modality-specific signals. Extensive experiments across three benchmark datasets demonstrate that SynGR achieves superior performance.

LLM pretraining is shifting from a compute-bound to a data-bound regime, where available human (organic) text falls far short of scaling demands. However, reaching the data-bound regime does not mean the model has fully utilized its organic corpus. In this paper, we introduce SynPro, a synthetic data generation framework that helps LLMs more thoroughly learn from limited organic data. SynPro applies two operations, rephrasing and reformat, that present the same organic source in diverse forms to facilitate deeper learning without introducing external information. Both generators are optimized via reinforcement learning with quality, faithfulness, and data influence rewards, and are continuously updated as pretraining plateaus to target content the model has yet to absorb. We pretrain 400M and 1.1B models with 10% of their Chinchilla-optimal tokens (0.8B and 2.2B) from DCLM-Baseline, reflecting a realistic data-bound regime in frontier pretraining. Our results reveal that organic data is significantly underutilized by standard repetition: SynPro unlocks 3.7-5.2x the effective tokens of repetition, even surpassing the non-data-bound oracle that trains on equivalent unique data at the 1.1B scale. Analyses confirm that faithful, model-aware synthesis sustains data-bound scaling without causing distribution collapse. We open-source our code at https://github.com/cxcscmu/SynPro.

The expansion of Artificial Intelligence-generated content service requires diffusion model serving to simultaneously achieve high throughput and low task end-to-end (E2E) latency. However, existing continuous batching methods suffer from severe resource contention during UNet-VAE concurrency, leading to latency spikes. Furthermore, concurrent multi-task scheduling entails a trade-off between UNet throughput and VAE latency across varying scheduling strategies. To address these, we propose SynerDiff, an efficient continuous batching system built on intra-inter level synergy. At the intra-concurrency level, SynerDiff alleviates resource contention by pruning component-specific resource bottlenecks via VAE Chunking and Adaptive Skip-CFG. At the inter-concurrency level, leveraging components' differential sensitivity to scheduling granularities, a threshold-aware scheduler plans concurrent sequences and tunes intra-concurrency decisions to minimize VAE latency while maintaining UNet within high-throughput threshold. Additionally, a feedback controller dynamically adjusts this threshold based on queue loads to boost system capacity ceiling. Experimental results show that, SynerDiff improves throughput by 1.6$\times$ and decreases both average E2E and P99 tail latencies by up to 78.7%, compared to benchmarks while guaranteeing high image fidelity.

Unifying multimodal understanding and generation is a compelling frontier that is beginning to emerge in the medical field. However, the limited existing unified medical models typically treat understanding and generation as disjoint objectives, lacking a meaningful functional synergy. In this work, we identify and address a critical question in unified medical modeling: what form of understanding truly benefits generation. We present SynerMedGen, a unified framework built on the proposed principle of generation-aligned understanding, which synergizes understanding objectives with generation tasks via task alignment. SynerMedGen introduces three generation-aligned understanding tasks and a two-stage training strategy that transfers generation-beneficial representations learned during understanding training to medical image synthesis. Remarkably, even with understanding training alone, our SynerMedGen achieves strong zero-shot performance across 22 medical image synthesis tasks and demonstrates robust generalization to unseen datasets. When combined with generation training, SynerMedGen consistently outperforms state-of-the-art specialized medical image synthesis models as well as recent unified medical models. We also release a large-scale dataset named SynerMed consisting of 1M paired synthesis samples and 2M generation-derived understanding instances to support further research on understanding-generation synergy. Our project can be accessed at https://github.com/piooip/SynerMedGen.

The bottleneck in learning-based industrial defect detection is often limited not by model capacity, but by the scarcity of labeled defect data: defects are rare, annotations are expensive, and collecting balanced training sets is slow. We present an end-to-end pipeline for synthetic defect generation and annotation, combining Vision-Language-Model-based prompts, LoRA-adapted diffusion, mask-guided inpainting, and sample filtering with automatic label derivation, and demonstrates the potential of real data with realistic synthetic samples to overcome data scarcity. The evaluation is conducted on, a challenging dataset of pitting defects on ball screw drives, and then on a subset of the Mobile phone screen surface defect segmentation dataset (MSD) dataset to test cross-domain transfer. Beyond downstream detector performance, we analyze key stages of the pipeline, including prompt construction, LoRA selection, and sample filtering with DreamSim and CLIPScore, to understand which synthetic samples are both realistic and useful. Experiments with YOLOv26, YOLOX, and LW-DETR show that synthetic-only training does not replace real data. When combined with real data, synthetic defects can preserve performance and yield modest gains in selected BSData training regimes. The MSD transfer study shows that the overall pipeline structure carries over to a second industrial inspection domain, while also highlighting the importance of domain-specific adaptation and annotation-quality control. Overall, the paper provides an end-to-end assessment of diffusion-based industrial defect synthesis and shows that its strongest value lies in strengthening scarce real datasets rather than substituting for them.

Controllable cooperative humanoid manipulation is a fundamental yet challenging problem for embodied intelligence, due to severe data scarcity, complexities in multi-agent coordination, and limited generalization across objects. In this paper, we present SynAgent, a unified framework that enables scalable and physically plausible cooperative manipulation by leveraging Solo-to-Cooperative Agent Synergy to transfer skills from single-agent human-object interaction to multi-agent human-object-human scenarios. To maintain semantic integrity during motion transfer, we introduce an interaction-preserving retargeting method based on an Interact Mesh constructed via Delaunay tetrahedralization, which faithfully maintains spatial relationships among humans and objects. Building upon this refined data, we propose a single-agent pretraining and adaptation paradigm that bootstraps synergistic collaborative behaviors from abundant single-human data through decentralized training and multi-agent PPO. Finally, we develop a trajectory-conditioned generative policy using a conditional VAE, trained via multi-teacher distillation from motion imitation priors to achieve stable and controllable object-level trajectory execution. Extensive experiments demonstrate that SynAgent significantly outperforms existing baselines in both cooperative imitation and trajectory-conditioned control, while generalizing across diverse object geometries. Codes and data will be available after publication. Project Page: http://yw0208.github.io/synagent

Human activity traces (HATs) are critical for many applications, including human mobility modeling and point-of-interest (POI) recommendation. However, growing privacy concerns have severely limited access to authentic large-scale HAT datasets. Recent advances in generative AI provide new opportunities to synthesize realistic and privacy-preserving HATs for such applications. Yet two major challenges remain: (i) HATs are highly irregular and dynamic, with long and varying time intervals, making it difficult to capture their complex spatio-temporal dependencies and underlying distributions; and (ii) generative models are often computationally expensive, making long-term, fine-grained HAT synthesis inefficient. To address these challenges, we propose SynHAT, a computationally efficient coarse-to-fine HAT synthesis framework built on a novel spatio-temporal denoising diffusion model. In Stage 1, we develop Coarse-HADiff, which models the overall spatio-temporal dependencies of coarse-grained latent spatio-temporal traces. It incorporates a novel Latent Spatio-Temporal U-Net with dual Drift-Jitter branches to jointly model smooth spatial transitions and temporal variations during denoising. In Stage 2, we introduce a three-step pipeline consisting of Behavior Pattern Extraction, Fine-HADiff, which shares the same architecture as Coarse-HADiff, and Semantic Alignment to generate fine-grained latent spatio-temporal traces from the Stage 1 outputs. We extensively evaluate SynHAT in terms of data fidelity, utility, privacy, robustness, and scalability. Experiments on real-world HAT datasets from four cities across three countries show that SynHAT substantially outperforms state-of-the-art baselines, achieving 52% and 33% improvements on spatial and temporal metrics, respectively.

Training multimodal large language models (MLLMs) for video understanding requires large-scale annotated data spanning diverse tasks such as object counting, question answering, and segmentation. However, collecting and annotating multimodal video data in real-world is costly, slow, and inherently limited in diversity and coverage. To address this challenge, we propose~\textbf{SynMulti} dataset, along with a unified synthetic data generation pipeline capable of automatically producing unlimited multimodal video data with rich and diverse supervision. Our framework supports multiple task formats within a single pipeline, enabling scalable and consistent data creation across tasks. To further enhance reasoning ability, we introduce a VQA-based fine-tuning strategy that trains models to answer structured questions about visual content rather than relying solely on captions or simple instructions. This formulation encourages deeper visual grounding and reasoning. We evaluate our approach in three challenging tasks: video object counting, video-based visual question answering, and video object segmentation. Experimental results demonstrate that models trained predominantly on synthetic data generalize effectively to real-world datasets, often outperforming traditionally trained counterparts. Our findings highlight the potential of unified synthetic data pipelines as a scalable alternative to expensive real-world annotation for multimodal video understanding.