Spatial Patching

Label-free virtual staining offers a compelling, non-destructive alternative to standard histopathology; however, its clinical adoption is hindered by the computational bottlenecks inherent to processing gigapixel Whole Slide Images (WSIs). Current deep learning approaches require patch-based inference to avoid memory constraints, which disrupts global tissue continuity and introduces tiling artifacts--displaying visible seams and color shifts. To address this, we introduce the Consistency Memory Bank (COMB), a novel label-free virtual staining framework that enforces spatial and channel consistency across tiles without memory bottlenecks. COMB decouples context storage from computation, utilizing a dynamic retrieval mechanism to fetch feature representations from adjacent tiles. This enables a retrieval-based context integration strategy that adopts local padding to resolve spatial discontinuities and neighbor-aware channel attention to stabilize statistical drift. Further optimized with a sliding window schedule to ensure minimal memory overhead, our method demonstrates superior performance over state-of-the-art baselines, achieving significant improvements in both perceptual fidelity and tiling consistency, while suggesting its downstream utility in tumor segmentation. Code is available at https://github.com/dou0000/COMB.

Histopathological subtyping relies on the recognition of characteristic histological patterns. These patterns may be expressed by individual tissue structures or by the spatial distribution and co-occurrence of multiple structures, and they often span irregularly shaped tissue regions, termed semantic units in this work. However, conventional patch-based representations may fragment such units and fail to explicitly preserve their internal spatial organization, while efficiently modeling relationships among numerous spatially separated units remains challenging. To address these limitations, we propose the Semantic-Aware Subgraph State Space Model (SASG-SSM), a flexible and efficient framework for whole slide image (WSI) classification. Semantic-Aware Subgraphs (SASGs) first approximate irregularly shaped semantic units by adaptively grouping spatially connected patches guided by class-agnostic visual-semantic priors. By representing patches as graph nodes with adjacency edges, SASGs preserve their internal spatial organization rather than treating them as an unordered set. A Subgraph State Space Module (SG-SSM) subsequently combines a graph neural network encoder for intra-subgraph topology encoding with a Mamba-based state space encoder for efficient contextualization across large numbers of subgraphs. This module integrates local structural information within semantic units with global contextual information arising from their distribution and co-occurrence across the WSI, while efficiently modeling a large number of spatially distributed regions. Extensive experiments across four WSI subtyping datasets demonstrate consistent advantages over representative state-of-the-art methods. Further evaluations under small-cohort and few-shot settings demonstrate robustness and data efficiency under limited training data. Code will be released at https://github.com/HLSvois/SASG-SSM.

Vision Foundation Models (VFMs) provide transferable patch representations for few-shot industrial anomaly detection, but their attention computation is typically inherited from pretraining objectives centered on semantic aggregation. This creates a potential mismatch: token relations that support semantic recognition may not adequately expose the localized texture and structural deviations required for anomaly localization. We therefore investigate the hypothesis that the attention computation of a frozen VFM can be reconfigured as a task-relevant component of anomaly detection. We instantiate this idea with Power-Law Self-Correlation Enhanced Attention (PL-SCEA), which retains the semantic context of pretrained query-key attention while constructing token-adaptive self-correlations over contextualized value features. Positive-correlation filtering and power-law reweighting then emphasize relations that are salient relative to each token's relational background, without introducing additional trainable attention projections. The resulting features are modeled by a lightweight variational autoencoder that provides a fixed-size reconstruction-based representation of category-specific normality. The two stages serve complementary roles: attention reconfiguration shapes how local relational deviations are represented, while reconstruction-based modeling converts deviations from learned normality into anomaly scores. Across MVTec AD and VisA, the complete framework achieves competitive image-level detection and consistently strong pixel-level localization across the evaluated few-shot settings. Ablations further show that PL-SCEA improves localization with either the VAE or a memory bank under the tested setting. These results support the view that task-aligned attention reconfiguration can improve the anomaly-localization capability of frozen pretrained representations.

Proactive tamper localization embeds an imperceptible signal into an image prior to distribution, enabling pixel-level manipulation detection. Existing methods assume a spliced (SP) setting, where synthesized regions are composited onto the original background, leaving embedded signals intact. However, real-world diffusion-based inpainting operates in a fully regenerated (FR) setting, where the entire image undergoes denoising, disrupting background signals and rendering existing frameworks ineffective. We propose APT, a semi-fragile latent-space perturbation that embeds a dense, vector-wise localization signal. By aligning each spatial feature vector toward a fixed anchor direction, APT localizes tampering via the alignment disparity between synthesized foreground and anchor-aligned background features after inpainting. The proposed hard negative mining loss and noisy perturbation branch further enforce uniform alignment. Experiments on COCO demonstrate that APT achieves an FR IoU of 0.92, outperforming the strongest baseline (WAM, 0.84), while existing methods collapse to near-random performance (AUC 0.5), establishing APT as a practical forensic framework generalizable across tampering types unknown at test time.

Visual classifiers are expected to generalize under data shifts, target shifts, and their combinations, yet most existing methods focus on domain invariance while failing to address intra-image predictive sufficiency. We investigate the structural hypothesis that each image contains a sample-adaptive oracle intra-image predictive subset sufficient for label prediction, while the remaining patches form non-essential complementary context that may correlate with the label. The theoretical analysis shows that restricting prediction to this oracle subset preserves the Bayes risk achievable by the full-patch representation while admitting a complexity bound that tightens with the oracle-subset size. Based on this view, we propose PatchGen, a text-free module that learns a sample-dependent soft predictive-subset mask as a task-driven proxy for the unobserved oracle subset mask. Specifically, histopathology visualizations suggest that PatchGen assigns higher scores to tumor-consistent regions than to some frequently co-occurring inflammatory context. Extensive experiments on natural and histopathological image benchmarks spanning all three shift settings show that PatchGen improves average performance over matched-backbone baselines in most evaluated configurations, enhances generalization to unknown classes, and remains competitive with vision-language methods without text supervision.

Self-supervised pretraining objectives are spatially uniform: the teacher temperature and the per-patch loss weight are identical everywhere in the image, so a lesion a few patches wide contributes no more to the training signal than the surrounding parenchyma. Prior work biases the views toward annotated regions, which changes what the model sees but adds no pressure on the objective. We instead condition the targets of self-distillation, a method we call SALT (Spatially Adaptive Label-guided Temperature). Weak, box-derived labels, available only during pretraining, define a compact region on the encoder's patch grid, inside which the teacher's softmax temperature is sharpened and the masked-patch loss is up-weighted. The objectives, the masking policy and the centering statistics are otherwise unchanged, and at every downstream use the encoder is a plain feature extractor with no labels and no conditioning. We evaluate by freezing the encoder and training only a lightweight multi-depth CenterNet-style head, detecting lesions in 3D on four CT cohorts, and we isolate the mechanism against a backbone identical in architecture, pretraining data, schedule and label-guided cropping but with no target conditioning. We report patch-level separability, 3D detection stratified by cohort and by lesion size, box quality, and a detector-free probe in which a single frozen patch embedding re-identifies a lesion in a follow-up scan without registration, masks or fine-tuning. Because the conditioning is expressed through a spatial indicator rather than through label semantics, the formulation admits any weak spatial annotation; we instantiate and validate it for lesions.

Overlapped friction ridge patterns are a recurring problem in latent fingerprints recovered from crime scenes and in live-scan scenarios where residual fingerprints on the sensor may corrupt subsequent acquisitions. Existing approaches for separating overlapped fingerprints either rely on rule-based orientation field completion that requires strong domain knowledge or train end-to-end deep neural networks that do not account for domain-specific considerations. This work introduces a diffusion-based pipeline for separating component fingerprints from an image containing overlapping friction ridge patterns. We formulate the separation problem as an inpainting task and progressively learn a diffusion model for this task in multiple stages. Starting from a pre-trained Stable Diffusion model, we progressively incorporate a fingerprint prior, add the ability to complete partial fingerprints, and finally propose \textbf{overlap-aware inpainting} that reconstructs each component print using a diffusion inpainting model based on multi-channel conditioning. Experiments on two public datasets demonstrate that component fingerprints reconstructed using the proposed diffusion-based inpainting method can match with their mated counterparts with very high probability.

Whole slide image (WSI) classification is an evidence-driven task, where diagnostic cues are often sparse, spatially organized, and class-dependent. Existing MIL and vision-language methods aggregate a large pool of patch features into a single global slide representation. Under few-shot supervision, limited slide-level labels make it difficult to learn a reliable aggregation mechanism that organizes sparse local cues into compact and coherent diagnostic evidence. Moreover, a shared slide representation compresses evidence supporting a candidate class and its alternatives into the same feature, limiting class-specific reasoning and interpretability. To address these issues, we propose EviBall, a class-conditioned evidence retrieval framework for few-shot WSI classification. EviBall organizes local patches into Evidence Balls through semantic-spatial assignment and center refinement, yielding compact and spatially coherent evidence units under weak supervision. It then uses task-specific class queries, including language-guided queries for morphology-oriented tasks and molecular-guided queries for molecular endpoint prediction, to retrieve supporting evidence balls and produce class-conditioned evidence representations for direct class-wise prediction. By introducing structured evidence units and task-relevant semantic guidance, EviBall reduces the reliance on learning an unconstrained global aggregation mechanism from scarce slide-level labels. It therefore reformulates few-shot WSI classification as structured evidence retrieval and competition among candidate classes. Extensive experiments across four morphology-oriented and molecular endpoint WSI tasks demonstrate that EviBall consistently outperforms conventional and vision-language MIL baselines under diverse few-shot settings, while providing spatially localized and class-specific evidence for each prediction.

Single-image self-supervised denoising replaces unavailable clean targets with surrogate targets constructed from noisy observations. Its effectiveness therefore depends on how closely the surrogate objective remains aligned with supervised denoising, especially when noise is correlated, spatially nonstationary, or unknown. We express the discrepancy between a broad class of MSE-based self-supervised objectives and supervised MSE as a parameter-independent constant and a trace interaction between the surrogate-target residual and the prediction error. The corresponding gradient discrepancy is determined by the gradient of this interaction. This formulation provides a common view of paired-noise, blind-spot, weak-noise, re-corruption, and sub-image methods, while revealing that a small global interaction may conceal substantial positive and negative regional interactions through spatial cancellation. Building on these observations, we propose LoTA-N2N, a two-stage zero-shot adaptation framework. Stage 1 trains a denoiser on complementary sub-image pairs and freezes it to construct detached clean-sub-image proxies. Stage 2 estimates the residual--prediction interaction using these proxies and suppresses its patch-wise absolute magnitude. We show that the local construction prevents spatial cancellation and upper-bounds the magnitude of the corresponding global interaction. Experiments across natural, confocal, and X-ray images, complemented by iteration-matched controls, controlled noise shifts, and gradient diagnostics, show consistent gains over MSE-only adaptation under IID, spatially varying, and mixed noise. Overall, LoTA-N2N demonstrates that estimated local interaction and spatial cancellation control provide effective design principles for single-image self-supervised denoising without paired clean targets, repeated acquisitions, or a predefined re-corruption model.

Vision foundation models have enabled strong training-free anomaly detection (AD). However, most existing approaches rely primarily on independent local patch features, leaving the global contextual information encoded by Vision Transformers (ViTs) underexploited. In this work, we identify the dual characteristics of the ViT [CLS] token: its embedding provides anomaly-invariant global semantic representation, while its attention maps implicitly highlight spatially abnormal regions. Building on this observation, we propose a fully automated AD framework leveraging global context to remove manual tunings. Our framework introduces (1) an automatic augmentation selection strategy driven by [CLS]-level semantic consistency, and (2) an attention-guided feature reweighting mechanism that dynamically adjusts patch contributions according to [CLS] attention saliency. By integrating these components over multi-level features, our method achieves stable anomaly scoring and precise localization without training or parameter tuning. Under the one-shot setting, it achieves Image-AUC scores of 97.7%, 93.2%, and 84.5% on MVTec-AD, VisA, and Real-IAD. Using a single fixed configuration across categories, backbones, and datasets, the method establishes a new state-of-the-art for plug-and-play, training-free anomaly detection while maintaining strong robustness and practical scalability.

Interactive deep image segmentation enables efficient medical image annotation by iteratively refining predictions from user prompts, such as positive and negative clicks. Recent patch-based methods, including nnInteractive, achieve strong segmentation performance but remain limited in annotation workflows by high interaction latency, limited responsiveness to successive interactions, and the lack of support for reversible prompting. Furthermore, evaluation relies predominantly on simulated rather than controlled real-user interaction studies. We present SLIP, an end-to-end trainable framework for interactive 3D medical image segmentation that decouples image encoding from prompt-guided refinement. Image features are computed once and reused, while a lightweight patch memory bank maintains an interaction-aware segmentation state shared across patches. This representation enables prediction updates by propagating interaction context throughout the image, supports reversible prompting without recomputing image features, and substantially reduces interaction latency. By separating image representation from interactive reasoning, SLIP remains compatible with a wide range of image encoders. We train a single SLIP model for general interactive segmentation across diverse anatomical structures and imaging modalities. Beyond standard simulated evaluation, we conduct a controlled prospective user study comparing manual segmentation, nnInteractive, and SLIP across three clinical annotation tasks, six expert participants, and subjective usability measures, addressing the limited human validation of interactive segmentation methods. SLIP achieves SOTA interactive segmentation performance across 13 public datasets while providing lower interaction latency, greater responsiveness, support for reversible prompting, and higher user preference than existing approaches.

Replacing an object with one that differs in category or shape requires complete source removal, natural target formation unconstrained by the source silhouette, and preservation of unrelated content. Existing training-free editors either localize edits from terminal predictions under source and target prompts or preserve unrelated content through spatially unselective source-feature reuse without explicit region discovery. Before reaching the terminal predictions, prompt-induced semantic differences undergo additional network transformations that may obscure their spatial localization, reducing localization precision. Spatially unselective feature reuse forces a trade-off between edit completeness and background preservation. Therefore, we propose PC-Edit, a prompt-contrastive framework for training-free MM-DiT editing. PC-Edit contrasts the image-token attention outputs under the source and target prompts, capturing prompt-induced semantic differences directly where text-conditioned information is delivered to image tokens. The same contrast identifies a source-erasure region during inversion and a target-emergence region during denoising. Their union suppresses source remnants while allowing the target object to form naturally. PC-Edit further couples region discovery and background preservation within each sampling step by estimating the current edit region from preceding attention blocks and immediately injecting cached source K/V features outside it in subsequent blocks, thereby protecting unrelated content before the latent update. Experiments on PIE-Bench and our EditRegion-Bench, with human-verified edit-region annotations for single- and multi-object addition and replacement, show that PC-Edit achieves the best editing quality and background preservation among methods without user-specified edit regions.

Recent advances in pathology foundation models have substantially improved patch and slide level representation learning from whole-slide images (WSIs).However, cell-level representations learning remain underexplored, limiting cell resolved interpretability, biological discovery, and clinical translation. We propose CellDETR, a detection-guided framework built on Deformable DETR for scalable cell representation learning from WSIs. By introducing location feature decoupling and box-constrained attention mechanism, CellDETR enables automated extraction of cell-level embeddings, and outperform existing state-of-the-art methods in supervised cell classification on PanNuke data. In addition, by incorporating contrastive learning design, we build a CellDETR-based pretraining model for scalable cell representation learning from unlabeled WSIs, which improves downstream cell classification performance. Furthermore, we show that after pretraining with Xenium spatial transcriptomics-derived cell annotations, CellDETR achieves accurate cross-dataset cell classification, demonstrating the transferability and biological relevance of the learned cell embeddings. Together, CellDETR provides a scalable route toward general cell-level representation learning framework for interpretable computational patholog

Pedestrian-level wind prediction is essential for urban design and wind-comfort assessment, but high-fidelity simulations such as LES remain computationally expensive for rapid evaluation. This study develops a two-stage U-Net framework for efficient prediction of time-averaged pedestrian-level wind speed over realistic urban morphologies. The model is trained and evaluated using the UrbanTALES dataset, which contains realistic city configurations under different approaching wind directions. In the first stage, a baseline U-Net model (M1) predicts wind fields patch-by-patch from normalised building height and fetch information. This formulation allows application to urban domains of arbitrary size, but independent patch inference can introduce discontinuities at patch boundaries. To address this, a second U-Net model (M2) is introduced as an inpainting-based refinement model. M2 uses a larger contextual window containing the initial M1 prediction and local morphology to reduce discontinuities using neighbouring flow information. During full-field inference, M2 is applied iteratively using a Gauss-Seidel scheme until convergence. Results show that M1 captures the main spatial distribution of pedestrian-level wind speed and performs well in low- and moderate-velocity regions, although high-velocity peaks are less accurate. M2 substantially reduces patch-boundary artefacts and improves spatial coherence. Across unseen urban cases, the framework reproduces mean velocity and spatial variability reasonably well, while maximum velocities remain underestimated. Overall, the proposed framework provides an efficient and flexible surrogate model for high-resolution pedestrian-level wind prediction across realistic urban morphologies.

Random initialization of convolutional filters does not use the training images. Previous work has shown that image patches can be copied into the first layer, and that k-means or principal components of patches can serve as filters. This paper compares four initializations of the first layer of a small convolutional network, with every other factor held fixed: He initialization, random mean-centered patches, principal components of those patches, and k-means centroids. Pre-Warm, our proposed methodology, is the rule-based use of both dictionaries: the patch count follows the filter count and a foreground density, both dictionaries are built from a single minibatch, and whichever of principal components or k-means better reconstructs those patches is written into the first half of the filter bank, rather than chosen by a validation search. The remaining filters stay random. On five datasets, principal components improve CIFAR-10 and CIFAR-100 relative to He initialization, and k-means improves SVHN and MNIST, and is the stronger of the two on Fashion-MNIST; copying raw patches does not reproduce those color-set gains. Use principal components on photographic patches and k-means on stroke-like patches; the first-batch reconstruction check recovers that split.

The rapid growth of digital pathology has created an urgent need for efficient indexing and retrieval of whole slide images (WSIs). This need is intensified by emerging generative AI workflows, particularly retrieval-augmented generation (RAG), which require dependable similarity search to support high-stakes clinical decision-making. Yet the substantial cost of high-performance storage limits the scalability and accessibility of WSI indexing for many healthcare institutions. Consequently, methods that can reduce storage demands while preserving retrieval accuracy have become a critical research priority. We propose ARReST (Antithetical Redundancy Reduction Strategy), a principled oppositional framework that leverages redundancy across dissimilar tissue classes to markedly decrease the number of patches that must be indexed from each WSI. Instead of eliminating only within-class duplicates, ARReST identifies antithetical patches-those whose representations contribute minimally to cross-class discrimination-and prunes them from the searchable archive. This targeted reduction substantially compresses the index without sacrificing morphological diversity or retrieval fidelity. By minimizing superfluous patch representations, ARReST reduces storage footprint, lowers computational overhead, and accelerates similarity search across large pathology repositories. Extensive experiments on TCGA repository (The Cancer Genome Atlas with 21 organs) demonstrate that ARReST achieves significant index compression while maintaining competitive retrieval performance. The observed storage savings of 3% to 60% (14%$\pm$13%) can be reliably achieved without compromising retrieval performance for many organs. The proposed strategy enables scalable, cost-efficient WSI indexing and is well-suited for next-generation retrieval-driven clinical AI systems.

Nowadays, more and more disasters of different natures are appearing. Several disaster assessment approaches have been developed in order to identify damaged areas from aerial images. These damaged areas contain rich material that could be recycled towards several ecological purposes. In this paper, we present a lightweight approach that permits the efficient detection of recyclable material. Experimental results show the potential of the proposed approach towards localizing recyclable materials. Accordingly, we provide a rare dataset of material images that we labeled towards supporting the development of recyclable material detectors. The dataset of labeled material images is publicly available at: anonymous.

While some individuals possess a natural talent for drawing, mastering this skill requires dedicated training and practice. Determining one's skill in the art of drawing requires proper comprehensive assessment. In this paper, we propose a method to measure drawing skill by by matching the hand-drawn image with the original template. Existing techniques often involve complex processes. However, advancements in computer vision allow us to train computers to perform these comparisons at a human-like level, thereby resolving the tedious and overwhelming traditional process. Using computer vision applications, determining image similarity involves identifying the level of similarities in an image with a reference image. We have implemented and analyzed the SIFT feature and Siamese network to measure image similarity. Our results indicate that it is feasible to assess art skill levels. Through feature analysis, we found that SIFT-based key point matching provides a more effective means of detecting drawing skills.

Small-area fingerprint sensing on mobile devices creates a fundamental mismatch between acquisition and recognition: each touch captures only a tiny, pose-varying local patch, while reliable biometric matching ultimately requires a stable and sufficiently complete fingerprint representation. Existing pipelines largely cope with this mismatch by treating repeated touches as independent partial templates, which leads to repeated registration, repeated matching, and no guarantee of adequate global coverage. In this paper, we advocate a different formulation, namely \emph{accumulative fingerprint mapping and reconstruction} for small-area mobile sensing. Rather than matching every partial patch separately, the proposed perspective converts a sequence of local observations into a unified fingerprint state that is progressively refined as new touches arrive and can be matched only once after consolidation. As a concrete baseline, we present a classical pipeline that performs patch-wise structural feature extraction, feature-level registration and fusion, fingerprint map construction, and phase-based ridge reconstruction. More importantly, we position this baseline within a broader mobile fingerprint framework that integrates structured token learning, two-stage pose reasoning, and diffusion-based generative reconstruction. This viewpoint reframes mobile fingerprint recognition from multi-capture multi-match processing to accumulative map building, state refinement, and one-shot matching, offering a principled route toward efficient, pose-robust, and deployment-friendly biometrics for small-area mobile platforms. The baseline implementation has been publicly released at https://github.com/XiongjunGuan/FpReconstruction.

Current virtual staining approaches offer the potential for time- and cost-efficient biomarker quantification in cancer diagnostics and prognostics. However, patch-wise inference for gigapixel whole slide images (WSIs) fails to maintain spatial continuity, yielding artifacts that cause catastrophic mismatches with ground-truth images. Although pathology Vision Foundation Models (VFMs) offer rich representations, their self-attention causes varying global contexts to produce inconsistent embeddings for the same physical region. We formalize and validate this ``context contamination'' as a sheaf-theoretic problem where these embeddings form a presheaf that violates the gluing axiom. To address this, we propose SheafStain, a new approach that reinterprets VFM features as sheaf-like sections for spatially and biologically coherent virtual staining. Specifically, SheafStain integrates class and patch tokens into a Schrödinger Bridge framework as sheaf-like sections. While the class token anchors biological consistency, patch tokens form a per-position spatial map. A backbone co-pretrained on Hematoxylin & Eosin (H&E) and Immunohistochemistry (IHC) yields non-degenerate cross-stain stalks, so a single VFM feature space supervises both input conditioning and output stain alignment. Departing from prior work that evaluates on isolated $256 \times 256$ patches and either random-crops or resizes the $1024 \times 1024$ ground truth, we translate at $256 \times 256$ and evaluate on the stitched $1024 \times 1024$ outputs across HER2, ER, PR, and Ki-67. SheafStain demonstrates promising results against six prior methods while mitigating patch-boundary stitching artifacts. Code will soon be released.

Foundation Models (FMs) have recently redefined the state-of-the-art in histopathology by providing robust representations for whole-slide image (WSI) analysis. However, selecting the optimal foundation model (FM) for a specific clinical cohort currently requires multiple preprocessing steps, followed by computationally expensive feature extraction and the training of a Multiple Instance Learning (MIL) aggregator for every model. In this work, we investigate whether efficient tile-level linear probing can serve as a reliable proxy for slide-level performance, reducing the need to run full slide-level pipelines for every candidate encoder. We benchmark 19 state-of-the-art FMs on 42 slide-level and 16 tile-level tasks, comparing tile probing metrics against slide-level outcomes using ABMIL and Mean Pooling aggregations. We observe a high correlation between tile and slide performance across varying task difficulties, indicating that encoder representation quality is the primary determinant of WSI success. Sensitivity analyses show that transferability is stable across models and is more influenced by cohort sizes and numbers of tiles per slide than by average task difficulty. We also measure the agreement in best performing models between tile and slide-level tasks, showing tile benchmarks reliably shortlist strong candidates. Overall, our study indicates that tile-level benchmarking provides an efficient and practical first step for narrowing down candidate models, while slide-level evaluation remains essential for final validation on clinical tasks.

Adaptive patching is a recent and compelling proposal for time-series Transformers: allocate finer patches where the sequence looks locally informative. This paper asks under what conditions a content-adaptive patching operator should outperform a tuned uniform one. Local heterogeneity alone is not enough: under pointwise forecasting losses, a complex-looking region is not automatically one where finer patching reduces the loss. We model patching as a budgeted bitrate allocation and derive an explicit threshold that a dynamic patching rule must satisfy to beat a well-tuned uniform baseline, then bound the achievable improvement both locally (a quadratic surrogate) and globally (a strong-convexity bound under the model's assumptions). Two structural results follow: without a coupling constraint, scalar local complexity cannot produce a non-uniform optimum under a common loss landscape; and once the backbone is trained to its representation-aware optimum, the alignment gain collapses around a well-tuned uniform patch size. To test these predictions, we run a controlled isolation study on three representative architectures, replacing each adaptive mechanism with a uniform patch-size sweep while keeping the backbone, data, and training protocol fixed. On standard long-horizon forecasting benchmarks, the validation-selected uniform baseline is competitive with the dynamic counterpart, with per-setting effects concentrated near zero and no consistent directional advantage once results are aggregated by dataset. The larger gains we do observe are method- and dataset-specific. Adaptive patching should therefore be evaluated against a tuned uniform baseline; its value depends on whether a cheap and reliable routing signal can identify where finer patches actually reduce forecasting loss.

Pathology foundation models are pretrained on large streams of WSI-derived patches, while supervision during data construction is often slide-level, sparse, or heterogeneous. This mismatch makes it difficult to understand and control which biological patterns enter the pretraining data. We propose SlideCheck, a lightweight pretraining data guidance tool built on frozen pathology foundation model patch features. Rather than serving as a standalone patch diagnostic model, SlideCheck provides explicit abnormality and malignancy scores for organizing, filtering, and auditing pathology pretraining data. SlideCheck uses a dual-head MLP to separately model broad abnormal morphology and malignant evidence. A regularized feature-space scorer provides a supervised anchor for patch-level evidence estimation, while score-attention agreement combines patch scores with WSI-level MIL attention to mine high-confidence pseudo labels. The same scores are then used to construct broad-positive ViT pretraining subsets, where a patch is selected if either abnormality or malignancy evidence exceeds a threshold. Experiments show that SlideCheck-defined data distributions influence the downstream behavior of self-supervised ViT pretraining, indicating that biological composition is an important controllable factor in pathology foundation model development. Curated subsets can approach full-data performance, suggesting that explicitly scored patch pools may support more efficient and auditable pretraining data construction. These findings position SlideCheck as a data guidance and auditing layer for transforming large, undifferentiated patch pools into controllable and reusable pretraining datasets.

Industrial visual anomaly detection is usually one-class: normal images are abundant, while defects are rare, heterogeneous, and often unavailable during system design. PatchCore-style retrieval suits this setting because it scores test images from a memory bank of normal patch features, but the standard Euclidean geometry ignores feature correlations and its offline construction materialises the full patch pool before subsampling. We introduce Mahalanobis PatchCore, a covariance-aware, streaming-compatible extension of PatchCore. Its artificial intelligence contribution is a retrieval detector that estimates a regularised covariance model in reduced feature space and whitens embeddings, so Euclidean nearest-neighbour search after transformation implements Mahalanobis retrieval. A bounded-memory, re-iterable training pipeline builds the memory bank without storing all normal patches at once, using incremental dimensionality reduction, online covariance estimation, and streaming aggregation. The engineering application is automated industrial inspection, where visual anomaly detection must remain accurate under practical memory limits. We evaluate the method on a public 15-category industrial anomaly-detection benchmark and three industrial datasets covering blow-fill-seal strip-ampoule meniscus inspection, amber-glass-ampoule bottom inspection, and lyophilised-cake vial inspection. Mahalanobis PatchCore preserves most offline PatchCore image-level performance on the public benchmark while reducing peak memory from 5.41 to 2.78 GB, and improves the selected industrial mean image area under the receiver operating characteristic curve from 0.981 to 0.986.

Vision-Language Models such as CLIP exhibit strong zero-shot recognition capability by aligning images with textual concepts, yet they often underperform on multi-label recognition where multiple objects co-exist. A key bottleneck is that the [CLS] token, as a single global visual representation, is insufficient to faithfully encode diverse targets with varying scales, contexts, and co-occurrence patterns. To address this limitation, we present a new multi-label image recognition framework, termed PIAA, which formulates prediction as Patch-level Inference followed by Adaptive Aggregation. Specifically, we first enhance patch-wise predictions from two complementary perspectives: (i) mitigating semantic entanglement in the visual encoder to obtain more discriminative patch representations, and (ii) learning an unsupervised visual classifier to narrow the vision-language modality gap. We then introduce an adaptive aggregation module that consolidates patch-level scores into the final multi-label prediction. Notably, the entire pipeline is fully training-free, requiring no gradient updates or parameter fine-tuning. Experiments show that our method achieves strong improvements with minimal extra computation, exceeding a 6% mAP gain on the challenging NUS-WIDE benchmark over representative baselines. Code is available at https://github.com/akang-wang/PIAA.

Pathology foundation models (PFMs) have emerged as a core approach for learning transferable representations from whole slide images (WSIs), and they are typically benchmarked through downstream clinical endpoints. While such task level evaluations are indispensable, they offer limited insight into what the representations themselves encode, particularly whether PFM embeddings can distinguish meaningful tissue regions and capture their spatial relationships. We present SpaPath-Bench, a representation level benchmark designed to diagnose spatial representation capability in PFMs. SpaPath-Bench formulates spatial domain identification (SDI) on paired whole slide image and spatial transcriptomics (ST) data as a diagnostic task. It curates 42 public paired WSI and ST slides, enables large scale evaluation across 19 encoders and seven SDI methods, and measures partition quality using three complementary criteria: unsupervised spatial coherence, transcriptomics referenced agreement, and expert referenced agreement. Across 83K runs, SpaPath-Bench reveals that different pretraining paradigms capture distinct aspects of tissue spatial architecture, and it provides practical guidance for building the next generation of spatially aware computational pathology models. Code and data pipelines are publicly available at https://bokai-zhao.github.io/SpaPath-benchboard/.

The neural-network denoising functions which form the backbone of image diffusion models are remarkably consistent in their generalization behaviour across a wide variety of network architectures and training procedure hyperparameters. A recent line of research has sought to model the outputs of these networks by aggregating posterior weighted averages of training dataset patches. In this work, we consolidate these approaches into a unified model class which we call Filtered Posterior Mean Collections (FPMCs). We define this model class using query precision vectors, response weights, and source distributions, and illustrate that existing methods are recoverable with specific choices of these design axes. Investigating each axis in turn, we find that FPMC performance can be improved with soft relaxations of prior patch-based methods, and through augmentations of source distributions. Applying these findings to an existing FPMC, we demonstrate consistent sample improvement across three natural image datasets.

Whole-slide MIL models are often called context-aware once graphs, Transform ers, or state-space modules are placed above patch embeddings. We show that this label can be deceptive. On pathology tasks where tissue architecture is part of the diagnostic signal, several strong MIL baselines retain nearly unchanged slide level AUC after patch coordinates are permuted. Their predictions are accurate, but largely compositional. We refer to this failure mode as spatial blindness. Our explanation is optimization-based: dense appearance statistics are learned early under slide-level supervision, leaving weak gradients for sparse spatial relations. ResTopoMIL addresses the issue by first fitting a permutation-invariant prototype histogram and then freezing it while a lightweight graph branch learns the residual under a coordinate-shuffling constraint. The architecture is simple by design; the intervention is in how the spatial branch is trained. Across 9 public WSI bench marks, ResTopoMIL improves classification and survival prediction with 1.15M parameters, restores sensitivity to coordinate perturbation, and gives stronger lo calization evidence on CAMELYON-16.

Class-Incremental Learning (CIL) enables models to continuously integrate new knowledge while mitigating catastrophic forgetting. Driven by the remarkable generalization of CLIP, leveraging pre-trained vision-language models has become a dominant paradigm in CIL. However, current work primarily focuses on aligning global image embeddings (i.e., [CLS] token) with their corresponding text prompts (i.e., [EOS] token). Despite their good performance, we find that they discard the rich patch-level semantic information inherent in CLIP's encoders. For instance, when recognizing a rabbit, local patches may encode its distinctive cues, such as long ears and a fluffy tail, which can provide complementary evidence for recognition. Based on the above observation, we propose SPA (Semantic-guided Patch-level Alignment) for CLIP-based CIL, which aims to awaken long-neglected local representations within CLIP. Specifically, for each class, we first construct representative and diverse visual samples and feed them to GPT-5 as visual guidance to generate class-wise semantic descriptions. These descriptions are used to guide the selection of discriminative patch-level visual features. Building upon these selected patches, we further employ optimal transport to align selected patch tokens with semantic tokens from class-wise descriptions, yielding a structured cross-modal alignment that improves recognition. Furthermore, we introduce task-specific projectors for effective adaptation to downstream incremental tasks, and sample pseudo-features from stored class-wise Gaussian statistics to calibrate old-class representations, thereby mitigating catastrophic forgetting. Extensive experiments demonstrate that SPA achieves state-of-the-art performance.

Text-guided inpainting has made image forgery increasingly realistic, challenging both SID and IFL. However, existing methods often struggle to point out suspicious signals across domains. To address this problem, we propose EDGER, a patch-based, dual-branch framework that localizes manipulated regions in arbitrary resolution images without sacrificing native resolution. The first branch, Edge-Guided Segmentation, introduces a Frequency-based Edge Detector to emphasize high-frequency inconsistencies at manipulation boundaries, and fine-tunes a SegFormer to fuse RGB and edge features for pixel-level masks. Since edge evidence is most informative only when patches contain both authentic and manipulated pixels, we complement Edge-Guided Segmentation with a Synthetic Heatmapping branch, a classification-based localizer that fine-tunes a CLIP-ViT image encoder with LoRA to flag fully synthetic patches. Together, Synthetic Heatmapping provides coarse, patch-level synthetic priors, while Edge-Guided Segmentation sharpens boundaries within partially manipulated patches, yielding comprehensive localization. Evaluated in the MediaEval 2025, SynthIM challenge, Manipulated Region Localization Task's setting, our approach scales to multi-megapixel imagery and exhibits strong cross-domain generalization. Extensive ablations highlight the complementary roles of frequency-based edge cues and patch-level synthetic priors in driving accurate, resolution-agnostic localization.

Accurate and effective discrete image tokenization is crucial for long image sequence processing. However, current methods rigidly compress all content at a fixed rate, ignoring the variable information density of images and leading to either redundancy or information loss. Inspired by information entropy, we propose TaTok, a Theoretically grounded adaptive image Tokenization framework. We rigorously identify two key drawbacks in existing methods: information insufficiency when reconstructing images with patch tokens alone, and information redundancy among patch tokens. To address these, we introduce global tokens that model mutual information across patch tokens, and a Dynamic Token Filtering (DTF) algorithm based on cumulative conditional entropy to eliminate redundancy. Experiments confirm TaTok's state-of-the-art performance, delivering a 1.3x gFID improvement and 8.7x inference speedup. By allocating tokens according to information richness, TaTok enables more compressed yet accurate image tokenization, offering valuable insights for future research.

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require aggregating thousands of patches for slide-level predictions. Multiple Instance Learning (MIL) tackles this challenge with a two-stage paradigm, decoupling tile-level embedding and slide-level prediction. However, most existing methods implicitly embed patch representations in homogeneous Euclidean spaces, overlooking the hierarchical organization and regional heterogeneity of pathological tissues. This limits current models' ability to capture global tissue architecture and fine-grained cellular morphology. To address this limitation, we introduce a hybrid hyperbolic-Euclidean representation that embeds WSI features in dual geometric spaces, enabling complementary modeling of hierarchical tissue structures and local morphological details. Building on this formulation, we develop BatMIL, a WSI classification framework that leverages both geometric spaces. To model long-range dependencies among thousands of patches, we employ a structured state space sequence model (S4) backbone that encodes patch sequences with linear computational complexity. Furthermore, to account for regional heterogeneity, we introduce a chunk-level mixture-of-experts (MoE) module that groups patches into regions and dynamically routes them to specialized subnetworks, improving representational capacity while reducing redundant computation. Extensive experiments on seven WSI datasets spanning six cancer types demonstrate that BatMIL consistently outperforms state-of-the-art MIL approaches in slide-level classification tasks. These results indicate that geometry-aware representation learning offers a promising direction for next-generation computational pathology.

The vulnerabilities of deep neural networks against singularities have raised serious concerns regarding their deployment in the physical world. One of the most prominent and impactful physical-world adversarial perturbations is the attachment of patches to clean images, known as an adversarial patch attack. Similarly, natural noises such as Gaussian and Salt&Pepper are highly prevalent in the real world. The current research need arises from the above vulnerabilities and the lack of efforts to tackle these two singularities independently and, especially, in combination. In this research, we have, for the first time, combined these two prominent singularities and proposed a novel dataset. Using this dataset, we have conducted a benchmark study of singularity data-point detection using features from several convolutional neural networks. For classification, rather than the popular neural network-based parameter tuning, we have used traditional yet effective machine learning classifiers. The extensive experiments across various in- and out-of-distribution (OOD) singularities reveal several interesting findings about the effectiveness of classifiers and show that it is hard to defend against adversaries when they are treated independently, and inefficient classifiers are selected.

Edge points on 3D point clouds can clearly convey 3D geometry and surface characteristics, therefore, edge detection is widely used in many vision applications with high industrial and commercial demands. However, the fine-grained edge features are difficult to detect effectively as they are generally densely distributed or exhibit small-scale surface gradients. To address this issue, we present a learning-based edge detection network, named EdgeFormer, which mainly consists of two stages. Based on the observation that spatially neighboring points tend to exhibit high correlation, forming the local underlying surface, we convert the edge detection of the entire point cloud into a point classification based on local patches. Therefore, in the first stage, we construct local patch feature descriptors that describe the local neighborhood around each point. In the second stage, we classify each point by analyzing the local patch feature descriptors generated in the first stage. Due to the conversion of the point cloud into local patches, the proposed method can effectively extract the finer details. The experimental results show that our model demonstrates competitive performance compared to six baselines.

Instruction-based image editing (IIE) aims to modify images according to textual instructions while preserving irrelevant content. Despite recent advances in diffusion transformers, existing methods often suffer from over-editing, introducing unintended changes to regions unrelated to the desired edit. We identify that this limitation arises from the lack of an explicit mechanism for edit localization. In particular, different editing operations (e.g., addition, removal and replacement) induce distinct spatial patterns, yet current IIE models typically treat localization in a task-agnostic manner. To address this limitation, we propose a training-free, task-aware edit localization framework that exploits the intrinsic source and target image streams within IIE models. For each image stream, We first obtain attention-based edit cues, and then construct feature centroids based on these attentive cues to partition tokens into edit and non-edit regions. Based on the observation that optimal localization is inherently task-dependent, we further introduce a unified mask construction strategy that selectively leverages source and target image streams for different editing tasks. We provide a systematic analysis for our proposed insights and approaches. Extensive experiments on EdiVal-Bench demonstrate our framework consistently improves non-edit region consistency while maintaining strong instruction-following performance on top of powerful recent image editing backbones, including Step1X-Edit and Qwen-Image-Edit.

Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies. With rising sequencing throughput and advancing platforms, the expanding data volumes motivate large-scale ST pretraining. However, the fundamental unit for pretraining, i.e., what constitutes a single training sample, remains ill-posed. Existing choices fall into two camps: (1) treating each spot as an independent sample, which discards spatial dependencies and collapses ST into single-cell transcriptomics; and (2) treating an entire slide as a single sample, which produces prohibitively large inputs and drastically fewer training examples, undermining effective pretraining. To address this gap, we propose treating spatial transcriptomics as croppable images. Specifically, we define a multi-channel image representation with fixed spatial size by cropping patches from raw slides, thereby preserving spatial context while substantially increasing the number of training samples. Along the channel dimension, we define gene subset selection rules to control input dimensionality and improve pretraining stability. Extensive experiments show that the proposed image-like dataset construction for ST pretraining consistently improves downstream performance, outperforming conventional pretraining schemes. Ablation studies verify that both spatial patching and channel design are necessary, establishing a unified, practical paradigm for organizing ST data and enabling large-scale pretraining.

DINO models provide rich patch-level representations that have recently enabled strong performance in unsupervised anomaly detection (UAD). Most existing methods extract patch embeddings from normal images and model them independently, ignoring spatial and neighborhood relationships between patches. This implicitly assumes that self-attention and positional encodings sufficiently encode contextual information within each patch embedding. In addition, the normative distribution is often modeled as memory banks or prototype-based representations, which require storing large numbers of features and performing costly comparisons at inference time, leading to substantial memory and computational overhead. In this work, we explicitly model spatial and contextual dependencies between patch embeddings using a 2D autoregressive (AR) model, allowing us to use a simple and efficient model for normative modeling. Instead of storing embeddings or clustering prototypes, our approach learns a compact parametric model of the normative distribution via an AR convolutional neural network (CNN). At test time, anomaly detection reduces to a single forward pass through the network and enables fast and memory-efficient inference. We evaluate our method on the BMAD benchmark, comprising three medical imaging datasets, and the VisA dataset, comprising 12 industrial object categories, and compare it against existing methods, including recent DINO-based approaches. Experimental results demonstrate that explicitly modeling spatial dependencies achieves competitive anomaly detection performance while substantially reducing inference time and memory requirements. Code is available at the project page: https://eerdil.github.io/spatial-ar-dinov3-uad/