Area Under The Receiver Operating Characteristic Curve

We introduce a proxy-analyzer framework for detecting hallucinations in large language models. Instead of looking inside the generating model, our system reads already-generated text through a small locally hosted open-weight model and spots hallucinations using the reader's own internal activations. This works just as well when the generator is a closed API like GPT-4 as when it is any open-weight model. We built eighteen features grounded in how transformers process text, covering residual stream norms, per-head source-document attention, entropy, MLP activations, logit-lens trajectories, and three new token-level grounding statistics. We trained a stacking ensemble on 72,135 samples from five hallucination datasets. We tested across seven analyzer architectures from 0.5 billion to 9 billion parameters: Qwen2.5 at 0.5B and 7B, Gemma-2 at 2B and 9B, Pythia at 1.4B, and LLaMA-3 at both 3B and 8B. Across all seven, we consistently beat ReDeEP's token-level AUC of 0.73 on RAGTruth by 7.4 to 10.3 percentage points. Qwen2.5-7B reached an F1 of 0.717, just above ReDeEP's 0.713, while Qwen2.5-0.5B hit 0.706. The most striking finding is how tightly all seven models cluster: AUC spans only 2.3 percentage points across an eighteen-fold difference in model size. Even more surprising, our 3B LLaMA outperforms our 8B LLaMA on RAGTruth, showing that bigger is not always better even within the same model family. Both RAGTruth and LLM-AggreFact include outputs from multiple LLM families, so our results are not skewed toward any particular generator.

We externally validated three deep learning models (DenseNet121, ViT-B/32, and ResNet50) for predicting mammographic breast density from breast ultrasound exams on an independent cohort. The external validation set comprised 2,000 ultrasound exams, including 500 cancer cases defined by an initial negative exam (BI-RADS 1 or 2) followed by a cancer diagnosis within 6 months to 10 years, and 1,500 negative controls matched by manufacturer and study year. Performance was measured using patient-level AUROC across four density categories: A (fatty), B (scattered), C (heterogeneous), and D (extremely dense). As a downstream assessment, we also evaluated 10-year risk prediction by incorporating age and AI-derived density into the Tyrer-Cuzick model and comparing performance against a reference model using age and mammography-reported density. All three models performed best in extremely dense breasts (AUROC 0.868-0.899), with strong performance in fatty (0.814-0.838) and scattered density (0.764-0.799), and lower performance in heterogeneously dense breasts (0.699-0.729). DenseNet121 achieved the highest overall performance (micro-averaged AUROC 0.885), and performance across categories was comparable between internal and external testing. For risk modeling, age combined with AI-derived density yielded a lower AUROC than age combined with mammography-reported density (0.541 vs. 0.570; p = 0.23), with no statistically significant difference. These findings indicate that deep learning models generalize well to external data with different racial composition for breast density assessment. While performance is strongest in extremely dense breasts, heterogeneously dense remains more challenging, highlighting the need for targeted optimization.

The rapid advancement in generative AI models has enabled the creation of photorealistic images. At the same time, there are growing concerns about the potential misuse and dangers of generated content, as well as a pressing need for effective AI-generated image detectors. However, current training-based detection techniques are typically computationally costly and can hardly be generalized to unseen data domains, while training-free methods fall short in detection performance. To bridge this gap, we propose a search-based method employing data embedding sensitivity in intermediate layers to detect AI-generated images. Given a set of real and AI-generated images, our method examines the similarity between original image embeddings and perturbed image embeddings, and detects AI-generated images based on the similarity. We examine the proposed method on two comprehensive benchmarks: GenImage and Forensics Small. Our method exhibits improved performance across different datasets compared to both training-free and training-based state-of-the-art methods. On average, our method achieves the largest performance gain on the Forensics Small benchmark by 39.61% compared to the best training-free method and 5.14% compared to the best training-based method in AUROC score.

With the increase of the Electronic Health Records (EHR) data, more and more researchers are developing machine learning models to learn from the medical notes. These unstructured text data pose significant challenges on the learning process as the quality of data is low. These data are often messy, repetitive and redundant. We have shown these notes data to be informative by conducting the after-discharge mortality rate prediction task. The AUC-ROC for models using the medical note information is generally 0.1 higher than those without the medical notes. Furthermore, we propose the Deep Neural Network(DNN) model with 'pooling' mechanism to enhance the mortality prediction. Based on the experimental results, we demonstrate that the proposed model outperforms the traditional machine learning models like the tree-based models. The proposed method learns from the most informative medical notes and improves the prediction accuracy significantly. The AUC-ROC for the proposed model is 2% to 14% higher than the traditional ones in 15-days, 30-days, 60-days, 365-days after-discharge mortality prediction tasks. Moreover, we can discover some interesting knowledge through the traditional and proposed models. These knowledge are inspiring but also consistent with the previous findings. The models are able to reveal the relationships between the informative keywords and documents from the medical notes and the severity of the patients.

Repeated sampling is a standard way to spend test-time compute, but its benefit is controlled by the latent distribution of correctness across examples, not by one-call accuracy alone. We study the binary correctness layer of repeated LLM inference under conditional-i.i.d. calls. One labeled call identifies the mean latent success probability; two labeled calls identify its second moment and hence the same-example correctness correlation that separates stable errors from recoverable call-level randomness. From these two moments, every fixed majority-vote budget has a sharp distribution-free two-call interval. The key technical reduction is that the infinite-dimensional moment problem has three-atom extremizers and quadratic dual certificates for every finite budget, so the bounds are exact rather than discretized or parametric. The first useful budget, three votes, has a closed form, width at most $1/8$, and a certified-improvement criterion. The infinite-vote endpoint is the limit of majority voting as the number of calls tends to infinity; it is also sharply bounded, but remains threshold-sensitive because it depends on latent mass around $q=1/2$. We add maximum-entropy and Latent-difficulty Gaussian-probit point completions, and experiments on LLM calls over QNLI and QQP show that empirical three- and five-vote accuracies are contained in the projected two-call regions while temperature changes and randomized model mixtures can create voting gains not ordered by one-call accuracy.

Donor-level disease classification from single-cell RNA sequencing (scRNA-seq) requires strict donor-aware cross-validation: naive pipelines that split cells randomly conflate training and test donors, inflating reported performance through pseudoreplication. We present a donor-aware benchmark evaluating three feature representations across two independent IBD cohorts: centered log-ratio (CLR) transformed cell-type composition, GatedStructuralCFN dependency embeddings, and scVI variational autoencoder latent embeddings. The cohorts are the SCP259 ulcerative colitis atlas (UC vs. Healthy, n=30 donors, 51 cell types) and the Kong 2023 Crohn's disease atlas (CD vs. Healthy, n=71 donors, 55-68 cell types across three intestinal regions). Compartment-stratified CLR composition achieves AUROC 0.956 +/- 0.061 on SCP259; GatedStructuralCFN on the same features achieves 0.978 +/- 0.050. In the Kong cohort, CFN achieves its best performance in the colon region (0.960 +/- 0.055 after feature filtering), exceeding linear CLR (0.900 +/- 0.100), while terminal ileum classification is dominated by linear models (CatBoost CLR 0.967 +/- 0.075 vs. CFN 0.811 +/- 0.164). Cross-dataset transfer (CD->UC, four shared cell types) achieves AUC 0.833 with XGBoost CLR; the reverse direction performs at chance. CFN edge stability analysis shows that compartment-wise composition eliminates spurious unit-sum-induced instability present in global composition (Jaccard 0.026 vs. top-20 recurrence 1.0). CFN shows a consistent numerical advantage over linear models in the colon region of CD (AUROC 0.960 vs. 0.900), though no inter-method comparison reached statistical significance at n<=34 donors per region. Compartment-aware feature construction is critical for both classification performance and structural interpretability. Code: https://github.com/Jonathan-321/sfn-scrna-study

Large Language Models (LLMs) have demonstrated remarkable capabilities across diverse natural language processing tasks, yet they remain susceptible to hallucinations -- generating content that is factually incorrect, unfaithful to provided context, or misaligned with user instructions. We present HalluScan, a comprehensive benchmark framework that systematically evaluates hallucination detection and mitigation across 72 configurations spanning 6 detection methods, 4 open-weight model families, and 3 diverse domains. We introduce three key contributions: (1) HalluScore, a novel composite metric that achieves a Pearson correlation of r = 0.41 with human expert judgments; (2) Adaptive Detection Routing (ADR), an intelligent routing algorithm achieving 2.0x cost reduction with only 0.1% AUROC degradation; and (3) systematic error cascade decomposition revealing substantial variation in hallucination error types across domains. Our experiments reveal that NLI Verification achieves the highest overall AUROC of 0.88, while RAV achieves the second-highest AUROC of 0.66.

Confidence calibration has been dominated by the Expected Calibration Error (ECE), a linear metric that counts calibration offset equally regardless of the confidence level at which it occurs. We show that ECE can remain small even under arbitrarily large overconfidence risk, so we propose Calibrated Size Ratio (CSR) instead, an interpretable metric that equals 1 under perfect calibration, from which we derive the risk probability $P_{\mathrm{risk}}$ that quantifies the statistical evidence for overconfidence. We further argue that overconfidence risk assessment must be complemented by a measure of discriminative value: whether the assigned confidences actively distinguish correct from incorrect predictions. We show that confidence-weighted accuracy $\mathrm{cwA}$ is the natural such complement, and that confidence-weighting extends to all standard classification metrics. In particular, we prove that the confidence-weighted AUC (cwAUC) captures the information about calibration while the classical AUC cannot. We validate the proposed indicators on several synthetic confidence distributions under multiple controlled calibration profiles and find that CSR separates risky from non-risky assignments. We also test the metrics on fifteen real datasets, with and without post-hoc calibration, and find that standard methods can yield risky confidence profiles.

Large language models (LLMs) are increasingly used for automated news credibility assessment, yet it remains unclear whether they apply even-handed standards across journalistic genres. We examine whether zero-shot LLMs are more likely to misclassify legitimate entertainment news as fake than legitimate hard news, using a within-dataset design on GossipCop from FakeNewsNet. Across four frontier models, we find a clear but model-specific genre asymmetry: DeepSeek-V3.2 and GPT-5.2 show false-positive-rate gaps of 10.1 and 8.8 percentage points, respectively (both $p < .001$), whereas Claude Opus 4.6 and Gemini 3 Flash show no comparable difference. A style-swap experiment yields only limited and inconsistent changes, suggesting that the asymmetry is not reducible to stylistic register alone. Prompt-based mitigation is likewise possible but not generic: framing the model as an entertainment-news fact-checker reduces false positives for DeepSeek-V3.2 by about 50% without detectable recall loss, but offers little improvement for GPT-5.2. Exploratory qualitative coding further suggests two recurring error patterns in sampled false positives: treating private-life claims as inherently unverifiable and discounting entertainment journalism as an epistemically weaker genre. Taken together, these findings show that aggregate performance metrics can obscure structured false positives within legitimate journalism. We argue that LLM-based credibility assessment may not only evaluate truth claims but also differentially recognize the legitimacy of journalistic genres, and that evaluation should therefore include genre-stratified false-positive analysis alongside overall accuracy.

Millimetre-wave (mmWave) radar offers a more privacy-preserving alternative to RGB-based human pose estimation. However, existing methods typically rely on pre-extracted intermediate representations such as sparse point clouds or spectrogram images, where the rich spatiotemporal information naturally present in radar video streams is discarded for model learning, while such signal processing adds system complexity. In addition, existing solutions are mainly conducted in an end-to-end supervised manner without leveraging unlabelled raw video streams to learn generalized representations. In this study, we present MAEPose, a masked autoencoding-based human pose estimation approach that operates directly on mmWave spectrogram videos. MAEPose learns spatiotemporal motion-aware generalized representations from unlabelled radar video, and leverages its heatmap decoder for multi-frame pose estimation predictions. We evaluate it across three datasets based on leave-one-person-out cross-validation with rigorous statistical testing. MAEPose consistently outperforms state-of-the-art baselines by up to 22.1% in MPJPE p<0.05, and maintains robust accuracy under zero-shot bystander interference with only a 6.5% error increase. Ablation studies confirm that both the pre-training and the heatmap decoder contribute substantially, while modality analysis indicates that leveraging Range-Doppler video as input achieves better pose estimation performance than Range-Azimuth or their fusion, with lower computational cost.

We show that pretrained acoustic embeddings classify elephant vocalisations at a level approaching that of end-to-end supervised neural networks, without any fine-tuning of the embedding model. This result is of practical importance because annotated bioacoustic data are scarce and costly to obtain, leaving conventional supervised approaches prone to overfitting and to poor generalisation under domain shift. A broad range of embedding models drawn from general audio, speech, and bioacoustic domains is evaluated, all of which are either out-of-domain (containing no bioacoustic data) or out-of-species (containing no elephant call data). The embedding networks themselves remain fixed; only the lightweight downstream classifiers, which include a linear model and several small neural networks, are trained. Among the models considered, Perch 2.0 achieves the best cross-validated classification performance, attaining AUCs of 0.849 on African bush elephant (Loxodonta africana) calls and 0.936 on Asian elephant (Elephas maximus) calls, with Perch 1.0 close behind. The best-performing system is within 2.2 % of an end-to-end supervised elephant call classification system. A layerwise analysis of pretrained transformer encoders, considered as embedding models, shows that intermediate representations outperform final-layer outputs. The second layer of both wav2vec2.0 and HuBERT encodes sufficient information for effective elephant call classification; truncation at this layer therefore preserves classification performance whilst retaining only approximately 10 % of the parameters of the full network. Such compact embedding networks are well suited to on-device processing where computational resources are limited.

The Receiver Operating Characteristic (ROC) curve of a binary classifier has often been utilized to measure the performance of the classifier. The area beneath this curve is used in particular because of its quoted probabilistic interpretation as being equal to the probability that the classifier will rank a random positive observation above a random negative observation. This paper formalizes this claim, produces a bound on how far away from the truth it is if a hypothesis is not met, and gives a small literature review of the ROC curve.

Pretrial risk assessment tools are used on over one million U.S. defendants each year, yet their use for predicting rare violent re-offense faces a basic statistical barrier. We derive a universal precision bound -- the Likelihood Ratio Wall -- showing that when violent re-arrest rates are low (2-5%), achieving even a 50% hit rate among people labeled "high risk" (positive predictive value, or PPV) would require tools far more discriminative than current instruments appear to be. For rare outcomes, a tool can have respectable-looking performance metrics and still be wrong most of the time it flags someone as "high risk for violence." We show that post-hoc score recalibration cannot solve this problem because it does not improve the tool's underlying ability to separate true positives from false positives. We further prove a Surveillance Ceiling: when over-policing inflates recorded "risk factors" among those who would not re-offend, the maximum achievable precision is structurally lower for over-policed groups, even at equal offense rates. We translate these results into the Number Needed to Detain (how many people must be detained to prevent one violent offense), and propose that risk reports should communicate this uncertainty explicitly. Our findings suggest that for rare violent outcomes, debates about fairness metrics alone are incomplete: under current data regimes, the available features may not support high-confidence individualized detention decisions.

Groundwater in the Densu Basin is increasingly threatened by heavy metal contamination, but conventional methods fail to capture the statistical complexity and spatial heterogeneity of pollution indicators. A key challenge is modelling the Heavy Metal Pollution Index (HPI), which is typically skewed and affected by correlated contaminants, leading to biased predictions without transformation. This study develops a predictive framework integrating response transformations with nested cross-validated ensemble machine learning. Three transformations (raw, log, and Gaussian copula) were applied to HPI and evaluated across six learners: support vector regression (SVM), $k$-nearest neighbours (k-NN), CART, Elastic Net, kernel ridge regression, and a stacked Lasso ensemble. Raw-scale models produced deceptively high fits (Elastic Net and stacked ensemble $R^2 \approx 1.0$), suggesting over-optimism. The log transformation stabilised variance (SVM: $R^2 = 0.93$, RMSE $= 0.18$; k-NN: $R^2 = 0.92$, RMSE $= 0.20$). The Gaussian copula gave the most reliable results: stacked ensemble $R^2 = 0.96$ (RMSE $= 0.19$), with other learners maintaining high accuracy. Copula-based models improved residuals and produced spatially plausible maps. DBSCAN clustering revealed Fe and Mn as primary HPI contributors, consistent with regional hydrogeochemistry. Limitations include reliance on random (not spatial) cross-validation and basin-specific scope. Future work should explore spatial validation and other geological settings. Overall, distribution-aware ensembles with clustering diagnostics offer robust, interpretable assessments of groundwater contamination.

Automated depression detection often relies on static aggregation of conversational signals, potentially obscuring clinically meaningful behavioral dynamics. We investigated whether entropy-driven temporal biomarkers improve depression detection beyond standard pooled features using the DAIC-WOZ corpus. Using 142 labeled participants, we reconstructed utterance-level acoustic trajectories and compared pooled temporal baselines, trajectory dynamics, Shannon entropy biomarkers, recurrence quantification, sample entropy, fractal complexity, and coupling biomarkers under leakage-aware validation. Static pooling achieved an AUC of 0.593, trajectory dynamics improved performance to 0.637, and entropy biomarkers produced the strongest statistically significant improvement over pooled baselines (AUC 0.646; nested cross-validated AUC 0.615; permutation p = 0.017). Entropy biomarkers outperformed recurrence, coupling, sample entropy, and fractalbased features, with several biomarkers stable across folds. These findings suggest depression-related signal may lie less in average acoustic levels than in entropy of conversational dynamics, supporting temporally informed digital phenotypes for mental-health assessment.

Photoplethysmography (PPG) is increasingly used in wearable affective computing due to its low cost and ease of integration into consumer devices. Recent advances in deep learning have introduced long-range sequence models, such as Transformers, and state-space models, like Mamba, which have demonstrated strong performance on natural language and general time-series tasks. However, it remains unclear whether these architectures offer tangible benefits over widely used Convolutional Neural Networks (CNNs) and Long Short-Term Memory (LSTMs) for PPG-based affect recognition, given that datasets are typically small and noisy. This work presents a measurement-driven comparison of four deep learning architectures, CNN, CNN-LSTM hybrid, Transformers, and Mamba, for classifying arousal, valence, and relaxation states from wrist-based PPG signals. All models are evaluated under a subject-independent 5-fold cross-validation protocol using identical preprocessing, segmentation, and training pipelines. Our results show that the Transformer and Mamba models achieve performance comparable to that of a CNN baseline, but do not consistently outperform it across all tasks. CNNs remain the most effective overall, providing the highest accuracy with the smallest model size, whereas Transformers have a better balance of F1 scores for Arousal and Relaxation. The study provides the first evaluation of Transformer and Mamba models for PPG-based affect recognition, offering practical guidance on model selection for wearable affective monitoring systems.

Accurate predictions of smallholder maize yields across national boundaries are critical for food security planning in sub-Saharan Africa, yet most published benchmarks report within-country performance that overstates true generalisability. This paper evaluates whether geospatial foundation model embeddings, specifically Prithvi-EO-1.0-100M and ViT-Base, outperform traditional Sentinel-2 spectral features under a Leave-One-Country-Out cross-validation scheme on 6,404 maize field observations from five African countries. The results show a clear generalisability gap: within-country random cross-validation yields moderate R^2 values, but all feature sets perform poorly under cross-country testing, with universally negative R^2. Frozen Prithvi-EO embeddings provide no meaningful advantage over engineered spectral features for cross-country prediction in this setting. The paper argues that the main limitation is a shift in yield distribution between countries rather than representation quality and releases a reproducible negative benchmark for future work.

Grading knee osteoarthritis (KOA) on plain radiographs is poorly reproducible across readers. A single-grade disagreement on the Kellgren-Lawrence (KL) scale can alter surgical management or redirect a patient from conservative therapy to intra-articular injection. Meanwhile, deep learning models that outperform human readers often offer no explanation for their decisions. We present Knee-xRAI, a pipeline that decomposes the grading process by mimicking clinical radiological workflows. It independently measures joint space narrowing (JSN), osteophytes, and subchondral sclerosis, then combines these findings into an explainable KL grade. Specifically, a U-Net++ architecture quantifies JSN via contour segmentation, an SE-ResNet-50 multi-task network grades osteophytes per anatomical site on the OARSI scale, and a hybrid texture-CNN detects binary sclerosis. This pipeline yields a 50-dimensional feature vector evaluated via an XGBoost-SHAP classifier (Path A, audit) and a ConvNeXt hybrid predictor (Path B, deployed). On 8,260 OAI-derived radiographs, the JSN module achieved a Dice score of 0.8909 and an mJSW ICC of 0.8674. Path A reached a QWK of 0.6294 and an AUC of 0.8046, confirming the structured feature vector carries substantial diagnostic signal. Path B achieved a QWK of 0.8436 and an AUC of 0.9017. SHAP analysis identifies JSN as the dominant feature, with osteophytes adding a consistent increment and sclerosis contributing marginally. Removing JSN evidence collapses KL3-KL4 recall while early grades remain intact, aligning with the KL diagnostic criteria. Knee-xRAI grounds every prediction in an auditable chain of measured radiographic findings, providing clinical transparency at the point of care.

Soil salinity is a major environmental challenge in coastal Bangladesh, threatening agricultural productivity and local livelihoods. This study develops a machine-learning-based framework to predict and map soil salinity in Satkhira district by integrating field observations with Landsat-derived spectral indices. A total of 205 soil samples collected during 2024-2025 were used to train an Extreme Gradient Boosting (XGBoost) model, and predictions were further improved using a Generalized Additive Model (GAM). Spatial cross-validation was applied to reduce autocorrelation bias, and bootstrap resampling was used to quantify prediction uncertainty. The results show strong spatial variability of soil salinity, with higher concentrations in the southern and central coastal regions and lower levels in the northern inland areas. Vegetation indices, particularly NDVI, along with salinity-related spectral indicators, were identified as key predictors. 10-year-window peak-exposure maps generated for 2014-2023 reveal recurrent high-salinity zones and a persistent, expanding footprint of moderate-to-high salinity exposure across the central parts of the district. Uncertainty analysis indicates higher variability in coastal zones and improved prediction stability when multi-year datasets are combined. The proposed framework provides a robust and scalable approach for long-term monitoring of soil salinity. It supports climate-resilient agriculture, land-use planning, and evidence-based decision-making in coastal Bangladesh.

The quality of diabetic retinopathy (DR) screening relies on the ability to correctly grade severity; however, many deep-learning (DL) classifiers cannot be easily interpreted in the clinical context. This study presents a methodology that combines strong discriminative models with multimodal explanations, converting retinal pixels into clinically interpretable outputs. Using the APTOS 2019 benchmark, we evaluated six representative CNN- and transformer-based backbones under a controlled protocol with stratified five-fold cross-validation. We then compared ensembling strategies (hard voting, weighted soft voting, stacking) and investigated a hybrid class-level fusion variant to exploit grade-specific advantages. For interpretability, we produced Grad-CAM++ visual attribution maps and short textual rationales using vision-language models (VLMs) conditioned on the fundus image and classifier outputs under conservative prompting constraints. Modern CNN backbones (ResNet-50 and ConvNeXt-Tiny) provided the strongest single-model baselines, with cross-validated QWK up to 0.919 and 0.914, respectively. Ensembling improved ordinal agreement, and weighted soft voting was the most consistent across folds (QWK 0.934 +/- 0.017). Hybrid class-level fusion was competitive but did not yield a statistically reliable improvement over standard fusion in paired fold comparisons (Holm-adjusted p >= 1.000). For explanation quality, Grad-CAM++ offered plausible but coarse localization, and VLM rationales were generally grade-consistent. Quantitatively, VLM variants showed a trade-off between clinical completeness and template-level semantic similarity (coverage 0.700 vs. BERTScore 0.072), while image-text alignment was comparable (CLIPScore approximately 0.34).

Anemia affects over one billion people globally and remains severely under-diagnosed in low-resource regions where laboratory blood tests are inaccessible. This paper presents AnemiaVision, an end-to-end web-based system for non-invasive anemia screening from smartphone photographs of the palpebral conjunctiva and fingernail beds. The proposed pipeline fine-tunes a pre-trained EfficientNet-B3 backbone with a redesigned three-layer classifier head incorporating BatchNorm, GELU activations, and high-rate Dropout (0.45/0.35). Training employs four orthogonal accuracy-boosting techniques: TrivialAugmentWide for policy-free image augmentation, RandomErasing for spatial regularisation, Mixup (alpha=0.2) for inter-class smoothing, and cosine-annealing scheduling with linear warmup. Early stopping is governed by peak validation accuracy rather than validation loss to prevent premature termination on high-variance epochs. The deployed Flask application integrates persistent patient-history management backed by PostgreSQL on Render, with an automated database-migration entrypoint ensuring zero data loss across redeploys. Ablation experiments demonstrate that accuracy-first early stopping contributes +1.6% and Mixup contributes +2.8% to final validation accuracy. Overall, the proposed system achieves a validation accuracy of 96.2% and AUC-ROC of 0.98, compared with 44.9% validation accuracy and AUC-ROC of 0.58 from the three-epoch CPU-only baseline. Sensitivity for the anemic class reaches 0.96, making the system suitable as a first-line screening tool for community health workers in rural settings. The system is publicly accessible and source code is openly available.

Objective: To propose and retrospectively validate an integrated framework addressing three barriers to clinical translation of readmission prediction: lack of explainability, absence of deployment reliability infrastructure, and inadequate demographic fairness evaluation. Materials and Methods: We constructed a cohort of 415231 adult admissions from the MIMIC-IV database (30-day readmission prevalence 18.0%), split 70/15/15. Logistic regression, XGBoost, and LightGBM models were trained on 26 features. SHAP provided per-patient explanations. Fairness was evaluated across 16 subgroups using AUC-ROC, false negative rate (FNR), and positive predictive value (PPV). Calibration was assessed using Brier scores and calibration curves. Results: XGBoost achieved AUC-ROC 0.696 (95% CI 0.691-0.701), outperforming or matching the LACE baseline (AUC 0.60-0.68). LightGBM achieved best calibration (Brier 0.146). Prior admissions were the dominant predictor. All subgroups met equity thresholds (delta AUC <= 0.05, delta FNR <= 0.10). Conclusion: This framework delivers competitive performance, clinically actionable explanations, and strong demographic equity. Code is publicly available at https://github.com/Tomisin92/readmission-prediction.

Nowadays, visual data forgery detection plays an increasingly important role in social and economic security with the rapid development of generative models. Existing face forgery detectors still can't achieve satisfactory performance because of poor generalization ability across datasets. The key factor that led to this phenomenon is the lack of suitable metrics: the commonly used cross-dataset AUC metric fails to reveal an important issue where detection scores may shift significantly across data domains. To explicitly evaluate cross-domain score comparability, we propose \textbf{Cross-AUC}, an evaluation metric that can compute AUC across dataset pairs by contrasting real samples from one dataset with fake samples from another (and vice versa). It is interesting to find that evaluating representative detectors under the Cross-AUC metric reveals substantial performance drops, exposing an overlooked robustness problem. Besides, we also propose the novel framework \textbf{S}emantic \textbf{F}ine-grained \textbf{A}lignment and \textbf{M}ixture-of-Experts (\textbf{SFAM}), consisting of a patch-level image-text alignment module that enhances CLIP's sensitivity to manipulation artifacts, and the facial region mixture-of-experts module, which routes features from different facial regions to specialized experts for region-aware forgery analysis. Extensive qualitative and quantitative experiments on the public datasets prove that the proposed method achieves superior performance compared with the state-of-the-art methods with various suitable metrics.

A hierarchical ensemble pipeline is introduced to address anomaly detection in multivariate telemetry data provided by European Space Agency (ESA). The method integrates shapelet-based and statistical feature extraction, per-channel modeling, intra-channel stacking, and a final cross-channel aggregation. The pipeline is trained and validated using time-series cross-validation and two-level masking strategies to prevent information leakage. Results on the European Space Agency Anomaly Detection Benchmark (ESA-ADB) challenge demonstrate strong generalization, highlighting the effectiveness of hierarchical modeling in detecting subtle anomalies in realistic satellite telemetry.

We evaluated whether a glaucoma risk assessment (GRA) model trained on All of Us national data can identify patients at high probability of glaucoma using only systemic electronic health records (EHR) at an independent institution. In this cross-sectional study, 20,636 Stanford patients seen from November 2013 to January 2024 were included (15% with glaucoma). A pretrained GRA model was fine-tuned on the Stanford cohort and tested on a held-out set using demographics, systemic diagnoses, medications, laboratory results, and physical examination measurements as inputs. The best model achieved AUROC 0.883 and PPV 0.657. Calibration was consistent with clinical risk: the highest prediction decile showed the greatest glaucoma diagnosis rate (65.7%) and treatment rate (57.0%). Performance improved with more trainable layers up to 15 and with additional data. An EHR-only GRA model may enable scalable and accessible pre-screening without specialized imaging.

Multi-class defect detection constitutes a critical yet challenging task in industrial quality inspection, where existing approaches typically suffer from two fundamental limitations: (i) the necessity of training separate models for each defect category, resulting in substantial computational and memory overhead, and (ii) degraded robustness caused by inter-class feature perturbation when heterogeneous defect categories are jointly modeled. In this paper, we present FPFNet, a Feature Perturbation Pool-based Fusion Network that synergistically integrates a stochastic feature perturbation pool with a multi-layer feature fusion strategy to address these challenges within a unified detection framework. The feature perturbation pool enriches the training distribution by randomly injecting diverse noise patterns -- including Gaussian noise, F-Noise, and F-Drop -- into the extracted feature representations, thereby strengthening the model's robustness against domain shifts and unseen defect morphologies. Concurrently, the multi-layer feature fusion module aggregates hierarchical feature representations from both the encoder and decoder through residual connections and normalization, enabling the network to capture complex cross-scale relationships while preserving fine-grained spatial details essential for precise defect localization. Built upon the UniAD architecture~\cite{you2022unified}, our method achieves state-of-the-art performance on two widely adopted benchmarks: 97.17% image-level AUROC and 96.93% pixel-level AUROC on MVTec-AD, and 91.08% image-level AUROC and 99.08% pixel-level AUROC on VisA, surpassing existing methods by notable margins while introducing no additional learnable parameters or computational complexity.

Industrial surface defect detection often suffers from limited defect samples, severe long-tailed distributions, and difficulties in accurately localizing subtle defects under complex backgrounds. To address these challenges, this paper proposes an unsupervised defect detection method that integrates a Denoising Diffusion Probabilistic Model (DDPM) with an asymmetric teacher-student architecture. First, at the data level, the DDPM is trained solely on normal samples. By introducing constant-variance Gaussian perturbations and Perlin noise-based masks, high-fidelity and physically consistent defect samples along with pixel-level annotations are generated, effectively alleviating the data scarcity problem. Second, at the model level, an asymmetric dual-stream network is constructed. The teacher network provides stable representations of normal features, while the student network reconstructs normal patterns and amplifies discrepancies between normal and anomalous regions. Finally, a joint optimization strategy combining cosine similarity loss and pixel-wise segmentation supervision is adopted to achieve precise localization of subtle defects. Experimental results on the MVTecAD dataset show that the proposed method achieves 98.4% image-level AUROC and 98.3% pixel-level AUROC, significantly outperforming existing unsupervised and mainstream deep learning methods. The proposed approach does not require large amounts of real defect samples and enables accurate and robust industrial defect detection and localization. \keywords{Industrial defect detection \and diffusion models \and data generation \and teacher-student architecture \and pixel-level localization}

Large language models frequently commit unrecoverable reasoning errors mid-generation: once a wrong step is taken, subsequent tokens compound the mistake rather than correct it. We introduce $\textbf{Latent Phase-Shift Rollback}$ (LPSR): at each generation step, we monitor the residual stream at a critical layer lcrit, detect abrupt directional reversals (phase shifts) via a cosine-similarity $+$ entropy dual gate, and respond by rolling back the KV-cache and injecting a pre-computed steering vector. No fine-tuning, gradient computation, or additional forward passes are required. LPSR achieves $\mathbf{44.0\%}$ on MATH-500 with an 8B model versus $28.8\%$ for standard AR ($+15.2$ pp; McNemar $χ^2 = 66.96$, $p < 10^{-15}$). Critically, prompted self-correction, the most natural inference-time baseline, scores only $19.8\%$, below standard AR; LPSR exceeds it by $+24.2$ pp ($χ^2 = 89.4$, $p \approx 0$). LPSR also outperforms Best-of-16 ($+7.8$ pp) at $5.4\times$ lower token cost, and surpasses a standard 70B model ($35.2\%$) with $8.75\times$ fewer parameters at ${\sim}3\times$ the token budget. A 32-layer sweep reveals a novel \textbf{detection-correction dissociation}: error-detection AUC peaks at layer14 ($0.718$) but task accuracy peaks at layer16 ($44.0\%$ vs.\ $29.2\%$), demonstrating that optimal monitoring depth differs for detection and correction.

The validity screen (Cacioli, 2026d, 2026e) classifies LLM confidence signals as Valid, Indeterminate, or Invalid. We test whether these classifications predict selective prediction performance. Twenty frontier LLMs from seven families were evaluated on 524 items across six cognitive tracks. Valid models show mean Type 2 AUROC = .624 (SD = .048). Invalid models show mean AUROC = .357 (SD = .231). Cohen's d = 2.81, p = .002. The tiers order monotonically: Invalid (.357) < Indeterminate (.554) < Valid (.624). Split-half cross-validation yields median d = 1.77, P(d > 0) = 1.0 across 1,000 splits. The three-tier classification accounts for 47% of the variance in AUROC. DeepSeek-R1 drops from 85.3% accuracy at full coverage to 11.3% at 10% coverage. The screen predicts the criterion. For selective prediction, the screen matters.

Predictions from machine learning algorithms can vary across random seeds, inducing instability in downstream debiased machine learning estimators. We formalize random seed stability via a concentration condition and prove that subbagging guarantees stability for any bounded-outcome regression algorithm. We introduce a new cross-fitting procedure, adaptive cross-bagging, which simultaneously eliminates seed dependence from both nuisance estimation and sample splitting in debiased machine learning. Numerical experiments confirm that the method achieves the targeted level of stability whereas alternatives do not. Our method incurs a small computational penalty relative to standard practice whereas alternative methods incur large penalties.

We present Veritas-RPM, a provenance-guided multi-agent architecture comprising five processing layers: VeritasAgent (ground-truth assembly), SentinelLayer (anomaly detection), DirectorAgent (specialist routing), six domain Specialist Agents, and MetaSentinelAgent (conflict resolution and final decision). We construct a 98-case synthetic taxonomy of false-positive scenarios derived from documented RPM patterns. Synthetic patient epochs (n = 530) were generated directly from taxonomy parameters and processed through the pipeline. Ground-truth labels are known for all cases. Performance is reported as True Suppression Rate (TSR), False Escalation Rate (FER), and Indeterminate Rate (INDR).

For head and neck cancer (HNC) patients, prognostic outcome prediction can support personalized treatment strategy selection. Improving prediction performance of HNC outcomes has been extensively explored by using advanced artificial intelligence (AI) techniques on PET/CT data. However, the interpretability of AI remains a critical obstacle for its clinical adoption. Unlike previous HNC studies that empirically selected explainable AI (XAI) techniques, we are the first to comprehensively evaluate and rank 13 XAI methods across 24 metrics, covering faithfulness, robustness, complexity and plausibility. Experimental results on the multi-center HECKTOR challenge dataset show large variations across evaluation aspects among different XAI methods, with Integrated Gradients (IG) and DeepLIFT (DL) consistently obtained high rankings for faithfulness, complexity and plausibility. This work highlights the importance of comprehensive XAI method evaluation and can be extended to other medical imaging tasks.

Borehole breakouts are stress-induced spalling on the borehole wall, which are identifiable in acoustic image logs as paired zones with near-symmetry azimuths, low acoustic amplitudes, and increased borehole radius. Accurate breakout characterization is crucial for in-situ stress analysis. In recent years, deep learning has been introduced to automate the time-consuming and labor-intensive breakout picking process. However, existing approaches often suffer from misclassification of non-breakout features, leading to high false positive rates. To address this limitation, this study develops a deep learning framework, termed Breakout-picker, with a specific focus on reducing false positives in automatic breakout characterization. Breakout-picker reduces false positives through two strategies. First, the training of Breakout-picker incorporates negative samples of non-breakout features, including natural fractures, keyseats, and logging artifacts. They share similar characteristics with breakouts, such as low acoustic amplitude or locally enlarged borehole radius. These negative training samples enables Breakout-picker to better discriminate true breakouts and similar non-breakout features. Second, candidate breakouts identified by Breakout-picker are further validated by azimuthal symmetry criteria, whereby detections that do not exhibit the near-symmetry characteristics of breakout azimuth are excluded. The performance of Breakout-picker is evaluated using three acoustic image log datasets from different regions. The results demonstrate that Breakout-picker outperforms other automatic methods with higher accuracy and substantially lower false positive rates. By reducing false positives, Breakout-picker enhances the reliability of automatic breakout characterization from acoustic image logs, which in turn benefits in-situ stress analysis based on borehole breakouts.

Automated classification of electrocardiogram (ECG) signals is a useful tool for diagnosing and monitoring cardiovascular diseases. This study compares three traditional machine learning algorithms (Decision Tree Classifier, Random Forest Classifier, and Logistic Regression) and three deep learning models (Simple Convolutional Neural Network (CNN), Long Short-Term Memory (LSTM), and Complex CNN (ECGLens)) for the classification of ECG signals from the PTB-XL dataset, which contains 12-lead recordings from normal patients and patients with various cardiac conditions. The DL models were trained on raw ECG signals, allowing them to automatically extract discriminative features. Data augmentation using the Stationary Wavelet Transform (SWT) was applied to enhance model performance, increase the diversity of training samples, and preserve the essential characteristics of the ECG signals. The models were evaluated using multiple metrics, including accuracy, precision, recall, F1-score, and ROC-AUC. The ECG-Lens model achieved the highest performance, with 80% classification accuracy and a 90% ROC-AUC. These findings demonstrate that deep learning architectures, particularly complex CNNs substantially outperform traditional ML methods on raw 12-lead ECG data, and provide a practical benchmark for selecting automated ECG classification models and identifying directions for condition-specific model development.

External validation is widely regarded as the gold standard for prognostic model evaluation. In this study, we challenge the assumption that successful external calibration guarantees model generalizability and propose two complementary strategies to improve transportability of prognostic models across cohorts. Using six real-world surgical cohorts from tertiary academic centers, we tested whether successful external calibration depends largely on similarity in covariates and outcomes between training and validation cohorts, quantified using Kullback-Leibler (KL) divergence, with calibration assessed by the Integrated Calibration Index (ICI). From the model-developer's perspective, we trained the "best-on-average" prognostic model by tuning toward a meta-analysis-derived covariate and outcome distribution as an approximation of the broader target population. From the end-user perspective, we proposed a simple measure for cohort outcome similarity to identify, among published models, the one most suitable for a given target cohort in terms of both calibration and clinical utility. External calibration worsened as distributional mismatch increased. Higher KL divergence was associated with higher ICI in both surgery-alone (Spearman $ρ=0.614$, $p=0.004$) and surgery + adjuvant chemotherapy cohorts (Spearman $ρ=0.738$, $p<0.001$). Meta-analysis-informed weighting improved calibration in most settings without materially affecting discrimination, with the clearest benefit when evaluated on the aggregated external population ($p=0.037$). Models developed in more similar cohorts achieved lower ICI in surgery-alone (Spearman $ρ=0.803$, $p<0.001$) and surgery + adjuvant chemotherapy cohorts (Spearman $ρ=0.737$, $p<0.001$), and provided greater clinical utility on DCA.

Large Language Models (LLMs) are increasingly exposed to adaptive jailbreaking, particularly in high-stakes Chemical, Biological, Radiological, and Nuclear (CBRN) domains. Although streaming probes enable real-time monitoring, they still make systematic errors. We identify a core issue: existing methods often rely on a few high-scoring tokens, leading to false alarms when sensitive CBRN terms appear in benign contexts. To address this, we introduce a streaming probing objective that requires multiple evidence tokens to consistently support a prediction, rather than relying on isolated spikes. This encourages more robust detection based on aggregated signals instead of single-token cues. At a fixed 1% false-positive rate, our method improves the true-positive rate by 35.55% relative to strong streaming baselines. We further observe substantial gains in AUROC, even when starting from near-saturated baseline performance (AUROC = 97.40%). We also show that probing Attention or MLP activations consistently outperforms residual-stream features. Finally, even when adversarial fine-tuning enables novel character-level ciphers, harmful intent remains detectable: probes developed for the base LLMs can be applied ``plug-and-play'' to these obfuscated attacks, achieving an AUROC of over 98.85%.

Robust segmentation of clinically significant prostate cancer (csPCa) on multi-parametric MRI must tolerate frequent degradation of its most informative diffusion sequences. Multi-modal fusion commonly employs learned modality gating under the assumption that gates implement per-sample modality quality routing -- rarely tested directly. We ask how gating behaves across backbone architectures. We systematically analyze modality-isolated gated fusion (MIGF) for csPCa segmentation on two backbones (nnU-Net and Mamba) using PI-CAI (n=1500), with cross-cohort validation on Prostate158 (n=158): a factorial ablation over gating, modality dropout, and deep supervision under 5-fold cross-validation (180 trained models), plus a gate-weight and counterfactual analysis of 30 trained gating models. Modality gating is backbone-conditional. On nnU-Net, adding gating reduces the ranking score (marginal effect -0.037; gating configurations p<0.05), whereas on Mamba the gating-plus-dropout configuration improves it (+0.024, p=0.037). Gate-weight analysis explains this: nnU-Net gates collapse into a near-static modality prior (across-case SD 0.0033), while Mamba gates retain sample-dependent variation (0.0365, ~11x larger, non-overlapping); replacing per-sample gates with their training-set mean leaves nnU-Net unchanged but degrades Mamba. Modality dropout is the only component beneficial on both backbones. Under cross-cohort shift, convolutional backbones collapse to case-level specificity near zero, whereas Mamba retains it (MIGF-Mamba highest, 0.31). Learned modality gates do not universally perform per-sample quality routing; their effective behavior is conditional on the backbone's inherent modality awareness. Among tested configurations, MIGF-Mamba is the most cross-cohort robust, and training-time modality dropout is the only component beneficial across both backbones.

Selecting LLM-generated code candidates using LLM-generated tests is challenging because the tests themselves may be incorrect. Existing methods either treat all tests equally or rely on ad-hoc heuristics to filter unreliable tests. Yet determining test correctness requires knowing which codes are correct, creating a \emph{circular dependency}. Our key insight is that we need not determine test correctness at all: \emph{test votes should rank, not merely count}. What matters is not how many codes pass a test, but whether the test can \emph{distinguish} correct from incorrect code. We break the circular dependency via leave-one-out evaluation: hold out one test, rank codes by their aggregate scores on all remaining tests, and measure whether the held-out test's pass/fail pattern agrees with this ranking. We formalize this agreement as the leave-one-out AUC~(LOO-AUC) and prove that the expected LOO-AUC is proportional to each test's ability to separate correct code from incorrect code. Building on this, we propose \textbf{ACES}~(\textbf{A}UC \textbf{C}onsist\textbf{E}ncy \textbf{S}coring) with two complementary variants: ACES-C provides closed-form weights that provably approximate the oracle in expectation under a mild assumption on average test quality; ACES-O drops this assumption and iteratively optimizes a differentiable LOO-AUC objective. Both operate solely on the binary pass matrix with negligible overhead, and achieve state-of-the-art Pass@$k$ on multiple code generation benchmarks.

Applying computational methods to law at scale requires separating genuine legal reasoning from surface similarity. We study this through a concrete task: detecting implicit citations of the French Civil Code, where a court applies a statutory rule without naming it: a post-hoc question about the reasoning a court actually used. We release a benchmark of 1,015 passage-article pairs annotated by three legal experts. Our central finding is that their disagreement is itself informative: the third of cases the experts dispute are where models fail. Our best ensemble reaches an F1 score of 0.70 overall. Yet, two-thirds of its false positives fall on those disputed cases, a concentration that holds across all ten models we evaluate. Disagreement is a signal of intrinsic difficulty, not annotation noise. This should not block useful tools, however: reframed as top-$k$ ranking with multi-model consensus, the same signals reach 76% precision for the top-200 candidates without supervision.

Portable CT scanners may support earlier stroke assessment, but reduced photon counts introduce noise that affects image quality and may alter automated classification. We compared direct classification of simulated low-dose slices with residual U-Net denoising followed by the same fixed classifier. Poisson noise was generated at photon-count scaling factors of 1, 5, 10, 20, and 40 using three deterministic seeds. The held-out set contained 809 slices, including 242 positive and 567 negative slices. Direct classification reached its highest mean ROC-AUC at a scaling factor of 20 (0.937 +/- 0.002). Denoising followed by classification reached 0.842 +/- 0.005 at a scaling factor of 1 and declined to 0.655 +/- 0.002 at a scaling factor of 40. Meanwhile, reconstruction quality rose steadily from 21.92 to 40.91 dB PSNR and from 0.761 to 0.987 SSIM. Both pathways had poor sensitivity at a fixed 0.5 cutoff because their classification scores were concentrated near zero. Patient-level analysis was limited by the test-set composition: all 10 patients were positive under the mask-derived patient label, preventing estimation of patient-level AUC and specificity. Overall, higher reconstruction fidelity did not translate into better discrimination by the fixed classifier except at the lowest photon-count setting.

Differential privacy (DP)'s effect in medical imaging is typically evaluated only through end-to-end performance, leaving the mechanism of privacy-induced utility loss unclear. We introduce Differential Privacy Representation Geometry for Medical Imaging (DP-RGMI), a framework that interprets DP as a structured transformation of representation space and decomposes performance degradation into encoder geometry and task-head utilization. Geometry is quantified by representation displacement from initialization and spectral effective dimension, while utilization is measured as the gap between linear-probe and end-to-end utility. Across over 594,000 images from four chest X-ray datasets and multiple pretrained initializations, we show that DP is consistently associated with a utilization gap even when linear separability is largely preserved. At the same time, displacement and spectral dimension exhibit non-monotonic, initialization- and dataset-dependent reshaping, indicating that DP alters representation anisotropy rather than uniformly collapsing features. Correlation analysis reveals that the association between end-to-end performance and utilization is robust across datasets but can vary by initialization, while geometric quantities capture additional prior- and dataset-conditioned variation. These findings position DP-RGMI as a reproducible framework for diagnosing privacy-induced failure modes and informing privacy model selection.

Drug-induced toxicity is a leading cause of preclinical and early-clinical failure, making early detection critical. Histopathology is the gold standard for toxicity assessment but relies on expert pathologists, creating a bottleneck for large-scale screening. We introduce an AI-based anomaly detection framework for whole-slide images (WSIs) of rodent liver that identifies healthy tissue and known pathologies (anomalies) and flags samples without training data as out-of-distribution (OOD). We evaluate OOD detection on two held-out categories: apoptosis (single-cell, near-OOD) and staining/processing artifacts (heterogeneous, far-OOD). We build a novel pixelwise-annotated dataset and fine-tune a pre-trained Vision Transformer (DINOv2) via Low-Rank Adaptation (LoRA) for segmentation, then use the Mahalanobis distance for OOD detection with class-specific thresholds. Optimizing the false positive rate subject to a predefined constraint on the false negative rate yields only 0.16% of pathological tissue classified as healthy and 0.35% of healthy tissue classified as pathological. Our false negative rate does not penalise cross-type errors, reflecting the safety-first objective of never overlooking a lesion; under the stricter correct-class criterion our method assigns 93.93% of ID and 89.38% of OOD findings to their own class. The study demonstrates technical feasibility of pixel-level anomaly detection for mouse liver histopathology, indicating possible applications in improving preclinical workflows and drug development efficiency.

The problem of corrupted data, missing features, or missing modalities continues to plague the modern machine learning landscape. To address this issue, a class of regularization methods that enforce consistency between imputed and fully observed data has emerged as a promising approach for improving model generalization, particularly in partially observed settings. We refer to this class of methods as Measure Consistency Regularization (MCR). Despite its empirical success in various applications, such as image inpainting, data imputation and semi-supervised learning, a fundamental understanding of the theoretical underpinnings of MCR remains limited. This paper bridges this gap by offering theoretical insights into when MCR yields a more favorable finite-sample estimation-error upper bound, viewed through the lens of neural network distance. Under ideal interpolation and compatibility conditions, we show that the MCR estimation-error upper bound is no larger than vanilla supervised training and becomes strictly smaller when the mixed-sample alternative is favorable. We then extend the analysis to the non-ideal regime, where optimization and compatibility residuals can potentially offset this finite-sample advantage. Guided by these insights, we propose a novel practical diagnostic that leverages the duality gap and a calibrated drift estimator to infer the potential benefit of MCR training. We present detailed empirical evidence to support our theoretical claims and to show the effectiveness and accuracy of our practical diagnostic. We further provide simulations on real-world datasets to show the versatility of MCR under different model architectures designed for different data sources.

Existing unstructured data analytics systems rely on experts to write code and manage complex analysis workflows, making them both expensive and time-consuming. To address these challenges, we introduce AgenticData, an innovative agentic data analytics system that allows users to simply pose natural language (NL) questions while autonomously analyzing data sources across multiple domains, including both unstructured and structured data. First, AgenticData employs a feedback-driven planning technique that automatically converts an NL query into a semantic plan composed of relational and semantic operators. We propose a multi-agent collaboration strategy by utilizing a data profiling agent for discovering relevant data, a semantic cross-validation agent for iterative optimization based on feedback, and a smart memory agent for maintaining short-term context and long-term knowledge. Second, we propose a semantic optimization model to refine and execute semantic plans effectively. Our system, AgenticData, has been tested using three benchmarks. Experimental results showed that AgenticData achieved superior accuracy on both easy and difficult tasks, significantly outperforming state-of-the-art methods.

Fairness audits are a key component of responsible machine-learning deployment. Yet, audit-recommendation reliability under incomplete protected-label access is still poorly understood. In this work, we focused on protected-label missingness in fairness mitigation audits. We introduced a seed-calibrated stress test to separate missingness effects from seed-to-seed movement already present under complete labels. Across ACS/Folktables tasks, missingness settings that retain some protected labels usually do not move selected mitigation methods beyond a complete-label seed-to-seed baseline. At $0$ protected-label access, candidates collapse to an empirical-risk-minimization baseline and deterministic tie-breaking rather than revealing a broad missingness effect. We also found that threshold optimization can turn fairness gains on a single protected axis into intersectional harm above a seed baseline, and this threshold-optimizer finding persists under random-forest validation. Overall, our results highlight that protected-label missingness should be reported with seed-null calibration, candidate-set context, and intersectional consequences before it is treated as evidence of audit fragility.

Many high-stakes screening tasks require predicting rare outcomes from unstructured text, where errors are costly and decisions must be auditable. We introduce Random Rule Forest (RRF), an interpretable ensemble that uses a large language model (LLM) not as an end-to-end predictor but as a generator of simple YES/NO questions. Each question acts as a weak learner, and their responses are combined by a plain unit-weight vote into an auditable ``green-flags'' scorecard: enough independent positive signals indicate a higher chance of success. We argue this deliberate simplicity is a robust default when positives are scarce and learned weights are hard to estimate. We evaluate RRF in two low-base-rate domains. On early-stage startup screening from founder profiles, RRF produces a transparent scorecard whose precision is several times the base rate (with light expert input raising it further) and, unlike direct prompting, its operating point can be controlled directly. On an established Phase~I clinical-trial benchmark, RRF outperforms published baselines on the threshold-independent metrics PR-AUC and ROC-AUC. Together these show that LLMs can serve as auditable feature generators for high-stakes text-based decisions, combining transparency with competitive predictive performance.

Given a high-dimensional covariate matrix and a response vector, ridge-regularized sparse linear regression selects a subset of features that explains the relationship between covariates and the response in an interpretable manner. To choose hyperparameters that control the sparsity level and amount of regularization, practitioners commonly use k-fold cross-validation. However, cross-validation substantially increases the computational cost of sparse regression as it requires solving many mixed-integer optimization problems (MIOs) for each hyperparameter combination. To address this computational burden, we derive computationally tractable relaxations of the k-fold cross-validation loss, facilitating hyperparameter selection while solving $50$--$80\%$ fewer MIOs in practice. Our computational results demonstrate, across eleven real-world UCI datasets, that exact MIO-based cross-validation can be competitive with mature software packages such as glmnet and L0Learn.

Cross-validation is one of the most widely used tools for risk estimation and model selection in statistics and machine learning, yet its theoretical properties when embedded in a learning procedure remain insufficiently understood. This paper develops a general, distribution-free framework for learning via model selection with cross-validation risk estimation within classical statistical learning theory. We establish VC dimension-based deviation bounds for the entire learning pipeline, providing detailed proofs for both bounded and unbounded loss functions, the latter requiring a novel extension of existing results. A central focus of the analysis is how the structure of the collection of candidate models influences generalization. To this end, we introduce Learning Spaces as collections of candidate models equipped with a partial order whose inclusion structure reflects increasing model complexity. We show how Learning Spaces can be constructed from domain knowledge and analyze how such structural information increases generalization. The framework is illustrated through case studies and a simulation study in high-dimensional linear regression, comparing learning via model selection in two distinct Learning Spaces against ordinary least squares, LASSO, and ridge regression across scenarios of varying alignment between prior knowledge and the true target. The results demonstrate that, when the Learning Space is well-adapted to the target and an efficient search algorithm is employed, learning via model selection can outperform standard methods by orders of magnitude. Through theoretical insights and concrete examples, we provide guidance on selecting the family of candidate models based on domain knowledge to enhance the performance of model selection with cross-validation.

Machine-learnt models are increasingly used to predict ISO 3382-1 room acoustic parameters at unmeasured seats from sparse measurements, with reported coefficients of determination frequently above 0.85. This paper shows that such figures are often determined by the evaluation protocol rather than by the model. Using a multi-condition measurement campaign in a 264-seat conference hall and a 180-seat concert hall, three model families were evaluated under a factorial protocol ablation: validation splits either row-based or grouped by receiver position, and inputs either including measured-at-test quantities (the target position's impulse response, co-located parameter measurements, position identifiers) or restricted to source-receiver geometry and environmental state. Row-based splits with measured-at-test inputs reproduce the high reported accuracies (mean R^2 of 0.81 for the core parameters); grouped splits with deployment-consistent inputs reduce these to 0.09-0.60 and reorder the apparent difficulty of parameter classes. Access to the target's own impulse response at test time reproduces the high accuracy of the row-based folds but provides no benefit under grouped folds. The row-based figure reflects condition interpolation at the measured positions rather than transferable acoustic information. Under the deployment-consistent protocol the spread between Random Forest, the hybrid network, and inverse-distance weighting is several times smaller than the spread between protocols for a fixed model; the learnt models retain a measurable advantage for sound strength and reverberation time, and the high accuracy of the original pipelines re-emerges as condition interpolation at measured positions, a distinct and operationally useful task. A reporting checklist operationalises the findings.

Frame-level area under the ROC curve (AUC) is the dominant evaluation metric for weakly supervised video anomaly detection (WSVAD). Its standard form measures whether an anomalous frame outranks a normal frame drawn from anywhere in the test set. We refer to this comparison as pooled AUC, since it aggregates frame pairs across test videos regardless of source. Pooled AUC therefore credits both event localization and differences between video sources. We audit this protocol on UCF-Crime across recent state-of-the-art models spanning different backbone families. Holding each model's frame scores fixed, we read them under three pairing granularities: global, per anomaly category, and within each video, then repeat the same three-granularity readout on zero-shot scores computed from the models' internal representations. We assess ranking reliability with a paired video bootstrap. Three findings follow. First, pooled AUC does not reliably predict within-video anomaly localization: models with similar pooled scores exhibit large localization differences and rank reversals under stricter granularities. Second, at the benchmark's test-split size, pooled AUC lacks the resolution to support state-of-the-art margins reported in the field. Within each backbone family, it resolves no comparison at those margins, while within-video AUC resolves several over identical predictions. Learned representations further reveal that within-video anomaly structure and detector localization are decoupled. Third, on normal footage alone, every model we examine separates videos by recording properties, such as resolution and color encoding, indicating that scene sensitivity is shared across the setting rather than specific to any architecture. We publicly release a granularity-aware protocol computable from existing predictions and scene-factor annotations for UCF-Crime.

Conversational speech reveals early signs of cognitive decline, including dementia and mild cognitive impairment (MCI). AI models show promise for speech-based screening, yet most research focuses on monolingual groups. In the UK, dementia is projected to rise fastest among Black and Asian communities, where multilingualism is common, making equity assessment critical. We recruited 1,395 participants (monolingual English speakers and multilingual speakers from Sheffield/Bradford) and collected over 263 hours of speech via the CognoMemory agent. Multilingual participants spoke English alongside Somali, Chinese, or South Asian languages (Hindi, Urdu, Punjabi, Mirpuri, Arabic). We evaluated ASR (Whisper, Wav2Vec 2.0, NeMo) and downstream AI models for cognitive classification and MMSE regression. ASR accuracy showed no significant differences across groups. However, downstream models exhibited systematic disparities: multilingual speakers were more often misclassified as impaired, especially in memory, fluency, and reading tasks. False-positive rates were substantially higher for multilingual (28 to 37%) than monolingual (12 to 16%) speakers, meaning multilingual individuals were approximately 2.5 times more likely to receive incorrect impairment labels. These biases worsened when models were trained on DementiaBank. This is the first large-scale analysis of false-positive bias in speech-based AI cognitive screening for UK multilingual ethnic minorities. Despite strong overall performance, current models show measurable disparities affecting multilingual speakers. Addressing these biases is essential for safe, equitable deployment in diverse healthcare settings.

Safety benchmarks for large language models often assess the risk of a user query, although the outcome of question answering depends on whether the response violates a policy. This distinction is critical in Chinese harmful-content evaluation, where linguistic variation and adversarial transformations can obscure risky intent. We introduce C-SafeQA, a policy-grounded benchmark for response-level Chinese safety evaluation. It comprises 538 base queries and 8,877 adversarial queries answered by four full-model LLM deployments, yielding 37,660 query-response records labeled safe, unsafe, or disputed. Reference labels are generated through agreement-aware multi-model adjudication and blind audits of stratified subsets by three safety experts. C-SafeQA supports both evaluation of target-model safety and auditing of seven automated safety judges against shared reference labels. Unsafe-response rates range from 0.93% to 3.35% on base queries and from 11.68% to 30.05% on adversarial queries. On the adversarial subset, judges show substantial trade-offs between unsafe-response recall and risk-query-conditioned safe-response false positive rate, and no judge dominates all metrics. Both acrostic transformations reduce unsafe recall for all seven judges, revealing mechanism-specific evaluator weaknesses. Dataset records, metadata, verification code, and judge scripts are publicly released to support recomputation, while benchmark construction, target-response generation, and private adjudication remain outside the release boundary.