Autonomous Research Agents

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31 papers in the last four weeks, up 82% on the four weeks before. 0.3% of all new papers.

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Latest papers 189

Jul 2, 2026cs.AI

SwarmResearch: Orchestrating Coding Agents for Open-Ended Discovery

Long-running coding agents such as autoresearch can persistently discover optimizations for open-ended problems. However, they tend to converge onto a single high-level approach, then proceed with low-level edits while missing other superior approaches to the problem. We hypothesize two harness-level design choices contribute to this behavior: accumulating context in a single long-running agent and only exposing a single program state to edit. We introduce SwarmResearch, an orchestrator-subagent harness in which a Shepherd Agent uses global context to steer a population of Search Agents, each operating with local context in their respective git branch. On open-ended optimization tasks, SwarmResearch discovers better or comparable solutions to state-of-the-art LLM-guided evolution and multi-agent techniques on 13/15 tasks, driven by higher-level exploration. Compared with fixed scaling of serial and parallel agents, SwarmResearch's orchestrator-guided scaling discovers better-performing solutions by adapting parallelism at different search depths.

Yuvraj Virk, Zack Edds, Chunqiu Steven Xia +1

University of Illinois Urbana-Champaign

Automated Algorithm Discovery Large Language Model-Guided Optimization LLM Agent Orchestration Multi-Agent Coding Autonomous Research Agents

Jul 2, 2026cs.AI

Grounded autonomous research: a fault-tolerant LLM pipeline from corpus to manuscript in frontier computational physics

Autonomous-research agents have demonstrated end-to-end LLM automation in machine-learning sandboxes where execution provides calibration. Frontier physical science differs categorically: physical reasoning underlies every methodology choice, toolchains are often underdocumented, and calibration must come from external literature anchors - which unscaffolded agents cite but do not confront, hallucinating plausible, unverifiable results from internal priors. We present a pipeline that runs end-to-end from a corpus of 11,083 recent condensed-matter physics arXiv papers to a publication-grade manuscript with three substantive physics findings (here on altermagnetic piezomagnetism): the agent autonomously conceives a research direction by mapping the corpus, calibrates methodology by reproducing published references, conducts novel first-principles computations, and writes the manuscript - grounded in literature throughout, across 47 fresh-context sessions in six phases sharing only on-disk state, with 2,162 literature-consultation events. Fault tolerance emerges from redundancy: fresh-context isolation, distributed grounding, and adversarial review catch what any single session misses; pre- and post-pilot stages are fully autonomous, and pilot requires bounded human intervention only at reproduction failures - operational knowledge curation, not scientific direction. Two paired failure modes - a pre-architecture baseline and a no-pilot ablation - isolate structurally enforced numerical confrontation at calibration checkpoints as the operative grounding mechanism. The primitives, characterized failure modes, and quantified intervention pattern lay a foundation for autonomous research in high-stakes scientific domains beyond computational physics.

Haonan Huang

Department of Physics, Princeton University, Princeton, NJ, USA.

Scientific Discovery Autonomous Research Agents LLM Agent Reliability

Jul 2, 2026cs.AI

Autonomous discovery of traffic laws with AI traffic scientists

Universal traffic laws describe recurrent patterns in congestion, mobility and driving behavior across cities, providing a scientific basis for transportation planning, management and control. Their discovery, however, remains expert-driven, requiring candidate regularities to be identified from heterogeneous observational evidence or validated through intervention experiments. Although autonomous artificial intelligence (AI) systems have advanced scientific discovery in controlled laboratory settings, extending them to complex transportation domains remains a challenge. Here we present TrafficSci, an agentic AI system that formulates traffic-law discovery as an iterative, auditable workflow integrating evidence scoping, critic-judge hypothesis induction, and observational-interventional validation. Across four case studies spanning population, network, control and trajectory scales, TrafficSci autonomously rediscovers three established traffic laws and identifies an unreported intrinsic temporal memory scale in urban driving behavior, statistically consistent across eight cities and two trajectory datasets. TrafficSci provides a route for extending AI-driven scientific discovery from controlled domains to complex urban systems.

Xingyuan Dai, Yue Liu, Xiaoyan Gong +9

State Key Laboratory of Multimodal Artificial Intelligence Systems, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China. · School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing 100049, China. · China Telecom Research Institute, Beijing, 102209, China. +2

Intelligent Transportation Systems Autonomous Scientific Discovery Autonomous Research Agents

Jul 1, 2026cs.AI

Auto-FL-Research: Agentic Search for Federated Learning Algorithms

Federated learning (FL) research often depends on many small but consequential algorithmic choices: optimizer variants, server aggregation rules, local training schedules, normalization, regularization, and model architecture. These choices are expensive to explore manually and difficult to compare fairly when candidate changes can also alter the FL training or evaluation path. In this work, we present Auto-FL-Research (AFR), a constrained coding-agent workflow for FL algorithmic recipe search. Agents may propose and implement candidate training algorithms, including server aggregation rules, client update schedules, local objectives, and registered model variants, while task profiles fix the mutation surface, compute budget, communication contract, and final model evaluation. Each campaign records candidate scores, runtime, edited files, artifacts, and failure status. We evaluate AFR on five healthcare cross-silo FLamby tasks and on grouped-client profiles for the five fixed LEAF datasets plus the LEAF synthetic task. Five-seed repeat evaluations support gains on four FLamby tasks and five of six LEAF profiles, while also exposing seed-sensitive and search-selected failure cases. Same-budget controls show that several gains correspond to FL-recipe changes, whereas other improvements are recovered by fixed-surface scalar controls or fail under repeat or held-out evaluation. These mixed outcomes are part of the contribution: they show how agent-generated candidates can be separated into repeated FL mechanisms, fixed-surface tuning effects, and selected single-run artifacts.

Holger R. Roth, Ziyue Xu, Chester Chen +3

NVIDIA, Santa Clara, USA

Automated Algorithm Discovery Autonomous Research Agents Federated Learning

Jun 30, 2026cs.AI

FARS: A Fully Automated Research System Deployed at Scale

Recent automated research systems show that language-model agents can generate hypotheses, run experiments, and write complete manuscripts, but most evidence still comes from selected examples, human-framed topics, or a few pre-defined research tasks. We present FARS (Fully Automated Research System), a fully automated AI-for-AI research system designed to operate across research topics at scale. FARS autonomously generates and advances projects through ideation, planning, experimentation, and writing, using stage-specific agents coordinated through a shared workspace that records proposals, code, logs, results, and manuscripts. In its first public deployment, FARS produced 166 complete research papers spanning 67 fine-grained AI/ML topics while preserving intermediate artifacts as an auditable corpus rather than a curated set of successes. We evaluate this corpus with 282 structured reviews from volunteer reviewers covering 140 papers, including overall ratings, sub-scores, integrity checks, and LLM-use disclosure. The reviews indicate that FARS can produce review-worthy and occasionally strong AI/ML research artifacts in a large-scale public deployment, while also exposing recurring failure modes in narrow experimental scope, methodological limitations, and integrity issues.

Qiong Tang, Tianxiang Sun, Xiangkun Hu +54

AI Agent Evaluation Autonomous Scientific Discovery Large Language Model-Guided Scientific Discovery Autonomous Experimentation Autonomous Research Agents

Jun 30, 2026cs.AI

One Reflection Is Not Enough: Self-Correcting Autonomous Research via Multi-Hypothesis Failure Attribution

Autonomous research agents can now draft hypotheses, write code, run experiments, and produce papers, but they remain brittle when experiments fail. Under the prevailing paradigm, failure recovery is usually delegated to a single free-form reflection: a rich trajectory of metrics, logs, and design choices is compressed into one verbal critique, which often leads either to localized trial-and-error or to hard pivots that discard useful context. We propose SAGE, a Self-correcting, Autonomous, Grounded Experimenter, to tackle this failure-recovery bottleneck. Its core mechanism, Multi-Hypothesis Failure Attribution (MHFA), treats recovery as a structured causal diagnosis. By analyzing dynamic trajectory features, MHFA systematically generates multiple evidence-grounded explanations for a failure, independently evaluates their severity, and deterministically routes the verified root cause to the correct intervention level (hypothesis, experimental design, or implementation). To guarantee scientific honesty, SAGE further employs a grounded reporting mechanism that explicitly constrains drafted results to actual measured values, redacting hallucinated numbers. On a 12-topic, 5-domain benchmark, SAGE increases metrics-bearing outputs from 42% to 92% over a reflection baseline, improves artifact quality from 5.00 to 6.75/10, and blindly outscores AI-Scientist-v2 (52.0 vs. 48.2), with gains concentrated in code development and execution. While fully autonomous scientific writing and generating conference-ready papers remain notoriously difficult open problems for the entire field, SAGE successfully produces significantly more reliable and higher-quality scientific artifacts. Ultimately, by coupling structured recovery with explicit grounding constraints, SAGE significantly outperforms monolithic reflection paradigms, establishing a highly trustworthy foundation for future autonomous research.

Jie Ma, Binfei Chu, Jie Gao +6

Xiamen University · Hello Inc. · Xiaohongshu Inc.

Agent Failure Analysis LLM Self-Correction Autonomous Experimentation Autonomous Research Agents

Jun 29, 2026cs.AI

Clarus: Coordinating Autonomous Research Agents toward Web-Scale Scientific Collaboration

Existing autonomous research agents can support parts of the research process, but most systems still treat research as either an isolated assistant task or a closed workflow. Therefore, autonomous science needs a collaboration infrastructure that coordinates projects, agents, and digital and physical resources. We identify this as a shift from code-centered execution loops to research-oriented collaboration processes, where questions, evidence, participants, and resources must be coordinated under uncertainty. In this framing, an agent may be an AI system, a human researcher, a team, a laboratory, or an organization-backed participant. To this end, we present Clarus, a collaboration infrastructure for coordinating autonomous research agents toward web-scale scientific collaboration. Clarus reformulates research as an open, auditable, attributable, and resource-aware multi-phase collaboration process. It defines a minimal project-agent-resource object model and organizes scientific collaboration through four layers including Research Application, Digital Collaboration, Physical Substrate, and Physical World. Core modules are implemented as pluggable mechanisms, allowing Clarus to adapt to task risk, collaboration structure, and resource constraints. Through a controlled paper-generation case study, we show that Clarus can organize a research goal into a traceable, reviewable, attributable, and accumulative collaboration network across phases, tasks, and participants. Together, the object model, collaboration protocol, trust mechanisms, and prototype validation provide an initial foundation for open research networks. Clarus is now available at clarus.holosai.io.

Zihan Guo, Zeyi Chen, Zhiyu Chen +15

Sun Yat-sen University · Shanghai Innovation Institute · Shanghai Artificial Intelligence Laboratory +4

Multi-Agent Orchestration Multi-Agent Collaboration Human-AI Collaboration Autonomous Research Agents

Jun 29, 2026cond-mat.mtrl-sci

Optimizing Expert-Designed Crystal Graph Networks for Band-Gap Prediction with an Autonomous LLM Research Loop

Predicting a material's properties from its structure is a central, fast-advancing problem in computational materials science. A decade of work has produced standard public benchmarks and many published machine-learning models for the task (Dunn et al., 2020). The task's fixed metric and these baselines make it a natural setting for autonomous agent research (Karpathy, 2026). On the MatBench band-gap benchmark (

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100k crystals), a general-purpose coding agent autonomously built the most accurate model trained without external pretraining, ahead of all seventeen expert-designed models reported for the task. A closer analysis shows it reached this by implementing known methods: either already standard in crystal neural-network models, or borrowed from other areas of machine learning. The contributing implementations include element-pair features on each message-passing edge and a crystal space-group embedding. The work not only demonstrates that LLM-agent autonomous research can optimize an expert-designed machine learning model for material property prediction, but also investigates the limitations of such autonomous research.

Chenmu Zhang, Boris I. Yakobson

Department of Materials Science and NanoEngineering Rice University Houston, TX 77005, USA

Graph Neural Networks Large Language Model-Guided Optimization Materials Property Prediction Autonomous Research Agents

Jun 25, 2026cs.MA

Glite ARF: Verifier-Driven Research with Parallel LLM Coding Agents

LLM coding agents make it tempting to automate empirical research by delegating experiments to them directly, but naive delegation does not scale to large projects: low-rate instruction lapses compound into broken, irreproducible artefacts. To address this problem, we present Glite ARF, an open-source Python framework for running many LLM coding agents in parallel on a research repository without sacrificing reproducibility or auditability. The framework defines a three-role stack: a human researcher chooses which hypotheses to test, coding agents (Claude Code, Codex CLI) implement individual tasks under a fixed structure, and deterministic Python verifier scripts enforce task isolation, immutability of completed work, a corrections overlay, and a materialised project overview. We call this verifier-driven research: the rules of the research process live in code that fails loudly when violated, not in prose that agents are merely asked to follow. Using Glite ARF, we developed our submission to the BEA 2026 vocabulary-difficulty shared task, placing first in the closed track and second in the open track on all three target languages (Spanish, German, Mandarin) and reducing the official baseline RMSE by 29.9% (closed) and 35.9% (open). The campaign comprised 273 tracked tasks (146 experiment runs) across 129 feature sets, run by up to twelve parallel agents orchestrated from a single laptop - with some model training on rented A100s - at approximately $450 in LLM API spend ($498 total third-party cost), and structured per-fold provenance let us catch and strip four target-leaking feature sets, correcting an implausible 0.609 RMSE to 0.802. Across three campaigns in three domains, the framework's structural machinery adds only about 1% of wall-clock time. Framework and a public demo project accompany this paper.

Vassili Philippov, Pavel Katunin, Dmitry Andreev +2

1Glite · School of Biosciences, The University of Sheffield, Sheffield, UK

Multi-Agent Coding Autonomous Research Agents LLM Agent Reliability

Jun 24, 2026cs.DL

Lacuna: A Research Map for Machine Learning

Lacuna is a research map for machine learning that uses LLMs to turn papers and scholarly metadata into markdown summaries, concept elements, research directions, and research proposals. Each item keeps links to the primary source records and papers that support it. We release the map with web, markdown, and MCP interfaces. Across LitSearch, Multi-XScience-CS/ML, and ScholarQA-CS-ML, Lacuna outperforms OpenScholar with the strongest gains on LitSearch retrieval (Recall@10 0.538 vs. 0.424 for OpenScholar v3). We also evaluate Lacuna Deep Research, a multi-stage report agent over the map, on 25 ReportBench-ML survey tasks: Lacuna Deep Research reaches 0.052 citation F1, 0.339 citation precision, 99 expert-reference hits, and 7.82/10 RACE report quality, while GPT-Researcher reaches 0.039 F1, 0.290 precision, 72 hits, and 5.24/10 RACE.

Martin Weiss, Miles Q. Li, Alejandro H. Artiles +4

Tiptree Advanced Systems Corporation · Mila · Polytechnique Montreal +2

Information Retrieval Large Language Model-Guided Scientific Discovery Autonomous Research Agents

Jun 23, 2026cs.AI

Heuresis: Search Strategies for Autonomous AI Research Agents Across Quality, Diversity and Novelty

Autonomous AI Research promises to accelerate the scientific progress of machine learning. To realise this goal, current Large Language Model (LLM)-based agents need to go beyond just writing code, to mastering the exploration of simultaneously performant, diverse and novel ideas. To this end, we introduce Heuresis, a framework that abstracts the research pipeline into a set of general and composable primitives, enabling open-ended scientific exploration in machine learning research. We implement six search strategies: a greedy baseline, two archive-based (MAP-Elites, Go-Explore), one evolutionary (Islands), and two divergent (Curiosity, Omni), and evaluate them across three axes (Quality, Diversity, and Novelty) on three domains (LLM Pretraining, On-Policy RL, and Model Unlearning), totalling 3,222 scored runs. We find that completely novel ideas are rare. No idea across our scored runs is rated as "Original", and only a few achieve only "Minor Similarity" to prior work. Moreover, novel ideas never approach the highest-performing known-recipe scores. Across all six strategies and three domains, only one such idea lands in the top-10 by quality. We also observed agents resorting to a variety of reward-hacking techniques during execution (40 confirmed fabrications across 1,628 scored runs), and detecting them was necessary to keep the search faithful to the task. Our results show that while current search and Quality-Diversity strategies enable us to steer where the generated ideas land on the quality, diversity, and novelty axes, they do not expand the quality-novelty frontier. Bridging this gap is the open challenge towards the ultimate goal of perpetual, autonomous scientific progress. Code is available at github.com/a-antoniades/Heuresis.

Antonis Antoniades, Deepak Nathani, Ritam Saha +6

University of California, Santa Barbara · Hexo AI

Novelty Search AI Agent Evaluation Quality-Diversity Optimization Research Idea Generation Autonomous Research Agents

Jun 23, 2026cs.AI

SP-Mind: An Autonomous Reasoning Agent for Spatial Proteomics Analysis

Spatial proteomics enables single-cell-resolution characterization of protein expression within tissue architecture, playing a critical role in understanding tumor microenvironments and guiding precision medicine. However, current analysis workflows remain fragmented, requiring expert manual orchestration of heterogeneous tools and limiting research scalability and reproducibility. We present SP-Mind, the first autonomous AI agent designed to unify the spatial proteomics analysis pipeline, from raw multiplexed tissue imaging to downstream phenotype discovery. Equipped with expert-curated biological analysis skills and specialized computational tools, SP-Mind converts natural-language queries into end-to-end analytical workflows without task-specific fine-tuning. To rigorously evaluate its capabilities, we introduce SP-Bench, a comprehensive benchmark spanning diverse tissue types, comprising 102 tasks across 18 distinct categories. Through extensive evaluation on SP-Bench and established downstream tasks, SP-Mind achieves state-of-the-art performance compared to existing open-source biomedical agent baselines.

Yucheng Yuan, Yuanfeng Ji, Zhongxiao Li +1

Department of Computer Science, Stanford University, Stanford, USA · Department of Radiation Oncology, Stanford University, Stanford, USA

AI Agent Benchmarks Tool-Using Agents Scientific Workflow Automation Autonomous Research Agents

Jun 23, 2026cs.SE

Agon: An Autonomous Large-Scale Omnidisciplinary Research System Built on Prompt Economy

Large language models are making research production scalable, shifting the bottleneck from producing artifacts to judging claims. We present \textsc{Agon}, a research orchestrator that validates what can be checked inside the workflow and leaves the remaining judgments to human scientists. \textsc{Agon} is built on six design principles: Prompt Economy, Future-Facing, Minimal Prompts, OmniDisciplinary, Massive Parallelism, and Zero-Code. We ran \textsc{Agon} across domains for 444 iterations of Prompt Economy loops, using only small starting topics and no human-written experimental code. These deployments demonstrate scalability while exposing new classes of failure. We organize these failures into a taxonomy along severity, fixability, visibility, and capability locus. The taxonomy separates failures the loops can see and fix from those that require human judgment. Together, these results show that \textsc{Agon} is pushing research toward a new paradigm: machine scales, human steers.

Youran Sun, Xingyu Ren, Chugang Yi +4

University of Maryland, College Park, College Park, MD, USA · The Chinese University of Hong Kong, Hong Kong, China · Stanford University, Stanford, CA, USA

AI Agents for Scientific Discovery Human-in-the-Loop AI Autonomous Experimentation Autonomous Research Agents LLM Agent Reliability

Jun 22, 2026cs.AI

Closed-loop Auto Research for Molecular Property Prediction: Discovering and Certifying Generalizable Improvements

Closed-loop Auto Research extends automated machine learning from fixed-dataset fitting to changing the research workflow, with language-model agents editing representations and model code and acquiring external evidence. Molecular property prediction spans many small endpoints. We ask whether this action space yields improvements generalizing beyond the validation signal selecting them. We isolate three Auto Research axes, features, models, and external evidence, under a file-level ablation lock attributing each gain to one axis over a strong baseline. Across 36 endpoints in three benchmark suites we score each selected configuration once on a held-out test whose labels the search never read. A routed pipeline taking each endpoint's best validation axis reaches positive held-out gains of 0.013, 0.011, and 0.042, the transferable axis differing by suite, data on TDC, model on Polaris, feature and model on MoleculeNet. The largest model-search gain falls from 0.041 on validation to 0.003 on test, while curated data reaches 0.022 but negative 0.019 on test, two non-transfer signatures. Curated external data raises held-out CYP2C9-substrate performance by 0.17 and half-life by 0.08, admitted through a contamination filter rejecting same-source files overlapping 64 to 89 percent of test structures, necessary but not sufficient for transfer. A matched-trial automated machine learning control did not reproduce the agent's code-level model intervention, reaching 0.006 against 0.042, and the pipeline stays competitive with an 84M-parameter pretrained 3D model on the shared training split. The experiments stay within molecular property prediction, but separating discovery from held-out certification is a domain-agnostic lesson for any closed-loop system optimising a proxy for a held-out quantity.

Jingjie Ning, Xiaochuan Li, Ji Zeng +2

School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. · DP Technology, Beijing, China.

Molecular Property Prediction Automated Machine Learning Large Language Model-Guided Scientific Discovery Autonomous Research Agents

Jun 21, 2026cs.AI

PaperClaw: Harnessing Agents for Autonomous Research and Human-in-the-Loop Refinement

Large language models have become capable reasoners and tool users that write and run code and search the literature, which makes automating the research process itself a realistic goal. We present PAPERCLAW, a harnessed multi-agent system that carries a project autonomously, from a field of study to a finished paper. PAPERCLAW curates a domain from a field's live literature, datasets, and code; brainstorms it into an idea with a pre-registered main-result contract; and drives a stoppable hypothesis map through an iterative propose, test, reflect loop that grows only from measured verdicts and halts once the evidence supports the idea, at which point it writes a venue-compliant paper. A full-lifecycle memory keeps each stage in a single living record, so a long run can be paused, inspected, and resumed without losing context. At the centre is an in-cycle research assistant with research tools and skills: it can drive the whole pipeline on its own, while the same interface lets a person step in at any stage, turning a first autonomous draft into a stronger paper through human-in-the-loop refinement. Throughout, PAPERCLAW keeps its output grounded and checkable, citing only references validated against open scholarly indexes and reporting results that genuinely ran. An evaluation with an LLM judge finds that PAPERCLAW produces strong papers both fully autonomously and with human-in-the-loop refinement.

Weiwei Ye, Hangchen Liu, Dongyuan Li +1

The University of Tokyo

Multi-Agent LLM Systems AI Agents for Scientific Discovery Human-in-the-Loop AI Autonomous Research Agents

Jun 19, 2026cs.AI

Negative Knowledge as Failure-aware Shared Memory for AutoResearch

AI-assisted research systems generate many failed attempts, but those failures rarely become a durable, shared knowledge asset. We propose a negative knowledge memory layer: a curator agent converts each failed attempt into a bounded, typed record in a shared bank, and a downstream research agent explicitly adopts or rejects those records before proposing its next experiment. We evaluate this layer in two settings: same-task retry on ScienceAgentBench and cross-task scientific research on two nonlinear math-physics PDE problems. The negative knowledge layer outperforms vanilla AutoResearch baselines while using fewer tokens; agents with the negative knowledge bank solve new tasks that all baselines fail to solve in PDE systems research. We also show that the previous negative knowledge bank can transfer and enhance AutoResearch on different PDE problems. These results suggest that structured negative knowledge is a knowledge asset that should be explicitly maintained in broader AI-engaged scientific research beyond a memory-compression or debugging aid, alongside positive findings, as a collective infrastructure for scientific memory. Code is available at https://github.com/hch-wang/Negative_Knowledge.

Hanchun Wang

Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.

AI-Assisted Scientific Research Memory-Augmented Agents Autonomous Research Agents

Jun 18, 2026cs.RO

Agentic AutoResearch forSpace Autonomy: An Auditable, LLM-Driven Research Agent for Aerospace Control Problems

Spacecraft guidance, navigation, and control functions are increasingly realized as learned policies distilled from expert solvers. Developing such a policy is itself a research process: an investigator selects an architecture and hyperparameters, runs experiments, and must determine whether an apparent improvement is genuine or merely seed noise. This paper presents AutoResearch, a framework in which a large language model autonomously drives that loop for aerospace control problems, coupled with a credibility layer, built into the loop, that certifies each reported result against the problem's own measured seed noise. The language model serves only as the offline research agent that develops the control policy; the trained policy it produces is then deployed onboard the spacecraft, while the model itself never operates the vehicle. At each iteration the agent reads a plain-language problem description and the run history, proposes a single edit to the training script, executes it, and logs the outcome. No reported result is credited until it passes the same three checks: measured per-problem seed noise, reseeded verification of the best configuration, and leave-one-out pruning of the agent's edits. The same loop is applied, unchanged, to two aerospace control problems: a Clohessy-Wiltshire relative rendezvous and a safety-constrained collision-avoidance docking past a keep-out zone, each calibrated against a known optimal control benchmark. In both, the audited policy clears the measured seed noise by many standard deviations; an undirected search over the same parameters does not. On the docking problem the gap becomes categorical: undirected search yields no feasible policy, while the learned policy stays outside the keep-out zone on every seed.

Amit Jain, Richard Linares

Massachusetts Institute of Technology, Cambridge, MA, 02139

Autonomous Experimentation Autonomous Research Agents

Jun 17, 2026cs.AI

Making AI Scientists Auditable from Evidence to Claim

AI research systems can report improved results without establishing that the tested implementation matches the method described in their conclusions. We introduce Xcientist, a research harness that connects literature review, component-based idea generation, experiment validation and reporting. An evidence graph retains source passages, methods, baselines and evaluation conditions; component records track design revisions; and validation contracts specify the implementation, comparisons and artifacts required at each stage. We define claim drift as an unresolved mismatch between an accepted claim and its attributed sources, code or experiments. A retrospective audit across agent memory, traffic forecasting and physics-informed learning found audit claim drift rates of 3.6--16.7% for Xcientist, lower than those of each of three comparison systems in all nine task-by-relation comparisons. This measure includes both confirmed mismatches and unverifiable claims; most of the difference arose from fewer unverifiable records. The case studies also document performance gains, unsuccessful revisions and limits on component attribution. This technical report describes the system, its implementation and the records needed to check how a proposed idea became a tested method and a final claim.

Zijian Wang, Hanqi Li, Ziyue Yang +17

X-LANCE Lab, School of Computer Science, Shanghai Jiao Tong University, Shanghai, China · Suzhou Laboratory, Suzhou, China · Shanghai Innovation Institution, Shanghai, China +1

Data Provenance Scientific Reproducibility Scientific Workflow Automation Autonomous Research Agents Scientific Claim Verification

Jun 16, 2026cs.AI

PseudoBench: Measuring How Agentic Auto-Research Fuels Pseudoscience

As Large Language Model based agents enter autonomous scientific research, their ability to resist pseudoscience becomes increasingly important. Otherwise, such systems may rapidly generate plausible yet misleading studies that contaminate academic literature and erode trust in science. We present PseudoBench, an adversarial benchmark for evaluating whether agentic auto-research systems can identify and resist pseudoscientific narratives. PseudoBench contains 200 curated pseudoscientific claim-evidence pairs across five domains and evaluates agents through an end-to-end research pipeline from experiments to writing. Testing seven state-of-the-art agents, we find that current systems readily produce persuasive reports that align with pseudoscientific premises with near-zero refusal rates and the highest resistance of only 27.4%. Stronger agents risk packaging pseudoscience in more sophisticated scientific language, increasing its apparent credibility. These findings reveal an alarming capacity to fuel pseudoscience, calling for scientific alignment before widespread deployment.

Xinyang Liao, Lingyu Li, Huacan Liu +5

Shanghai Artificial Intelligence Laboratory · Shanghai Jiao Tong University

AI-Assisted Scientific Research AI Agent Safety Benchmarks Autonomous Research Agents

Jun 12, 2026cs.AI

Democratizing and accelerating AI-driven pathology research through agentic intelligence

Computational pathology has advanced rapidly with the emergence of foundation models, yet widespread adoption remains limited by substantial technical complexity and programming requirements. Here we present PathLab, an autonomous agentic framework that translates natural-language research objectives into executable and validated computational pathology workflows through the structured composition of domain-specific skills and tools. By organizing workflow generation around reusable methodological modules, including data preprocessing, model development, evaluation and interpretation, PathLab enables studies to be specified at the level of scientific intent rather than implementation details. We evaluated PathLab across 12 public datasets spanning four representative task families: region-of-interest classification, whole-slide image classification, segmentation and survival prediction. Across all task categories, PathLab achieved non-inferior performance relative to expert implementations, while consistently enforcing semantic validity of user prompts and proactively rejecting incompatible workflow specifications prior to execution. In controlled user studies, PathLab substantially reduced the time required to generate executable analytical pipelines and enabled domain experts without programming experience to independently design, execute and evaluate computational pathology studies. Together, these results establish PathLab as a reliable interface between biomedical intent and computational execution, enabling computational pathology studies to be designed at the level of scientific questions rather than programming expertise. By lowering technical barriers to advanced AI methodologies, PathLab provides a foundation for the broader democratization of computational pathology.

Jiabo Ma, Cheng Jin, Yihui Wang +19

Department of Computer Science and Engineering, Hong Kong University of Science and Technology, Hong Kong SAR, China · Department of Pathology, Nanfang Hospital, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China · Guangdong Province Key Laboratory of Molecular Tumor Pathology, Guangzhou, China +9

Computational Pathology Agentic Workflows Scientific Workflow Automation Autonomous Research Agents

Jun 11, 2026cs.AI

EurekAgent: Agent Environment Engineering is All You Need For Autonomous Scientific Discovery

LLM-based agents have shown increasing potential in automating scientific discovery. Given an optimizable metric and an execution environment, they can propose, validate, and iterate scientific solutions, and have produced results that outperform human-designed approaches. As model capabilities continue to improve, we argue that the bottleneck for autonomous scientific discovery is shifting from prescribing agent workflows to designing agent environments: the resources, constraints, and interfaces that shape agent behavior. We frame this as environment engineering: building environments that amplify productive behaviors, such as open-ended exploration, systematic artifact management, and inter-agent collaboration, while suppressing harmful behaviors, such as reward hacking and high-friction human oversight. We present EurekAgent, an environment-engineered agent system for metric-driven autonomous scientific discovery. EurekAgent engineers the environment along four dimensions: permissions engineering for bounded agent execution and isolated evaluation; artifact engineering for filesystem and Git-based collaboration; budget engineering for budget-aware exploration; and human-in-the-loop engineering for easy human supervision and intervention. EurekAgent sets new state-of-the-art results on multiple mathematics, kernel engineering, and machine learning tasks, including new state-of-the-art 26-circle packing results discovered with less than $11 in total API cost. We open-source our code and results, and call for environment engineering as a core research direction for developing reliable autonomous research agents.

Amy Xin, Jiening Siow, Junjie Wang +5

Department of Computer Science and Technology, Tsinghua University · School of Information, Renmin University of China

Autonomous Scientific Discovery Autonomous Research Agents LLM Agent Reliability

Jun 10, 2026cs.AI

Arbor: Tree Search as a Cognition Layer for Autonomous Agents

Arbor is a multi-agent framework that introduces structured tree search as a cognition layer for autonomous agents operating in large, stateful action spaces. Prior autonomous optimization systems operate on isolated targets with stateless evaluation. Arbor instead maintains an explicit search tree of scored hypotheses that serves as the shared working memory across agents, evolving with every measurement, treating failures as diagnostic signal that reshapes subsequent exploration, and expanding as prior successes shift the bottleneck distribution. We validate Arbor on full-stack LLM inference optimization, a domain where achieving peak performance has historically required coordinated effort from engineering teams across the application, framework, compiler, kernel, and hardware stack. Arbor pairs an Orchestrator agent, which drives optimization by delegating to Domain Specialists across the inference stack, with a Critic agent that safeguards stability through root-cause analysis, introspection, and measurement validation -- a checks-and-balances architecture where neither agent can unilaterally drive the system. Agent capabilities are decomposed into hard skills (domain expertise) and soft skills (coordination protocols that determine how contributions compose), enabling fully autonomous multi-day campaigns. Arbor achieves up to 193% inference throughput-latency Pareto improvement over vendor-optimized baselines, while a single agent without the harness plateaus at +33% throughput improvement and crashes irrecoverably within hours. Arbor generalizes to multiple generations of hardware platform, and run-to-run variance is within 2 percentage points demonstrating that the method is hardware-agnostic and reproducible.

Neha Prakriya, Chaojun Hou, Zheng Gong +5

Training and Inference Optimization Team AMD

LLM Inference Efficiency Multi-Agent System Optimization Multi-Agent Orchestration Autonomous Experimentation Autonomous Research Agents

Jun 10, 2026physics.ao-ph

CMIP-Forge: An Agentic System that Retrieves, Computes, and Self-Reviews Climate Science

The Coupled Model Intercomparison Project Phase 6 (CMIP6) has generated thousands of peer-reviewed publications documenting model configurations, evaluation procedures, emergent constraints, and projection uncertainties. As the community transitions toward CMIP7, efficiently extracting and operationalizing this unstructured knowledge alongside live data analysis represents a critical bottleneck. Here we present CMIP-Forge, a hybrid retrieval-augmented generation (RAG) and autonomous analysis system that bridges the gap between scientific literature and Earth System Grid Federation (ESGF) data archives. The system pairs a curated corpus of 6,581 CMIP6-related open-access publications (101,828 indexed chunks) with an agentic pipeline in which a tool-augmented worker plans and executes Python workflows over live climate data, while a panel of independent reviewer models audits its methodology end to end. CMIP-Forge introduces a multi-layered Defense-in-Depth architecture that enforces physical and methodological invariants through executable mechanisms: Abstract Syntax Tree (AST) static analysis, audited scientific primitives, and an autonomous adversarial peer-review protocol. We demonstrate the system's capabilities through end-to-end autonomous research pipelines spanning atmospheric teleconnections, ocean dynamics, regional extremes, and global warming projections. An agentic analysis system grounded in peer-reviewed literature, constrained by automated code guardrails, and audited by an independent adversarial review loop can complete complex climate-research workflows autonomously. The same experiments expose concrete failure modes of the review loop (sycophantic regression, REVISE verdicts that are never resolved, and the submission of stub code for review), each diagnosable from the immutable telemetry and provenance record released with the article.

Dmitrii Pantiukhin, Boris Shapkin, Ivan Kuznetsov +2

Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Bremerhaven, Germany

Climate Science Climate Modeling Agentic RAG Automated Peer Review Scientific Workflow Automation Autonomous Research Agents

Jun 10, 2026cs.CL

Toward Generalist Autonomous Research via Hypothesis-Tree Refinement

Scientific progress depends on a repeated loop of exploration, experimentation, and abstraction. Researchers test candidate directions, interpret the evidence, and carry the resulting lessons into later attempts. We study how an AI agent can run this loop autonomously over long horizons. We introduce Arbor, a general framework for autonomous research that combines a long-lived coordinator, short-lived executors, and Hypothesis Tree Refinement (HTR), a persistent tree that links hypotheses, artifacts, evidence, and distilled insights across time. The coordinator manages global research strategy over the tree, while executors implement and test individual hypotheses in isolated worktrees. As results return, Arbor updates the tree, propagates reusable lessons, refines the search frontier, and admits verified improvements. This design turns autonomous research from a sequence of local attempts into a cumulative process in which strategy, execution, and evidence are carried across time. We evaluate Arbor under Autonomous Optimization (AO), an operational setting where an agent improves an initial research artifact through iterative experimentation without step-level human supervision. Across six real research tasks in model training, harness engineering, and data synthesis, Arbor achieves the best held-out result on all six tasks, attaining more than 2.5x the average relative held-out gain of Codex and Claude Code under the same task interface and resource budget. On MLE-Bench Lite, Arbor reaches 86.36% Any Medal with GPT-5.5, the strongest result in our comparison.

Jiajie Jin, Yuyang Hu, Kai Qiu +15

Gaoling School of Artificial Intelligence, Renmin University of China · Microsoft Research

Long-Horizon LLM Agents Autonomous Experimentation Autonomous Research Agents

Jun 9, 2026cs.AI

Search Discipline for Long-Horizon Research Agents

Autoresearch agents now propose, evaluate, and select scientific candidates against a metric, and that metric is usually an aggregate reduced over a heterogeneous space of regions, slices, or cohorts. We show that when scientific validity lives in that disaggregated structure, the aggregate can rank the wrong candidate first. The headline number improves while the structure underneath inverts, so a decision made on the number accepts a candidate that quietly breaks the model. The failure is not domain-specific. It appears wherever a candidate's validity is multi-dimensional but its verifier is a single reduction. We demonstrate the inversion on a fire-model task in the Ecosystem Demography model. The highest-scoring candidate and a slightly lower one are within noise of each other on global score, yet the top-scoring one collapses the protected boreal regions while the other preserves them. What separates them is the per-region behavior, not the headline number. This decision should not be left to the agent that produced the candidates. The agent optimizing the score is the last party likely to catch the score being wrong, and a prompt has no remaining turn once the agent has stopped. We move the decision to an external control loop that audits each candidate on its disaggregated behavior and acts after the agent has decided. It can demote a candidate the agent would have accepted, and it can reopen a run the agent had declared finished. Our contribution is the inversion finding itself, and a search-discipline protocol that decides on reviewable candidate-effect evidence instead of the score.

Adithya Srinivasan, Devesh Paragiri

Department of Computer Science · North Carolina State University · University of Maryland

AI-Assisted Scientific Research Long-Horizon Agent Evaluation Autonomous Research Agents

Jun 9, 2026cs.AI

What Fits (Into Few Tokens) Doesn't Overfit: Compression and Generalization in ML Research Agents

Reusing a held-out benchmark adaptively should, in principle, invite overfitting. Yet benchmark-driven machine learning (ML) has produced surprisingly little overfitting in practice. An attractive hypothesis is that successful ML strategies are highly compressible. We study this in the setting of LLM-driven research agents, where the hypothesis becomes directly testable via two complementary information bottlenecks. In \emph{output compression}, an exploration agent adaptively searches for high-performance models using a validation set, and we test whether a fresh ``reproducer agent'' can reproduce its performance given only an extremely short prompt and the training data. In \emph{input compression}, the explorer receives only one-bit feedback indicating whether each submitted model improves on the running best. Across 8 datasets spanning tabular classification, vision, language modeling, diffusion modeling, and reward modeling, we find that these bottlenecks have little effect on performance: short prompts and compressible feedback are sufficient to reproduce and find high-performance models. The hypothesis is falsifiable: when we deliberately induce validation-set overfitting, the results fail to reproduce with short prompts. Taken together, our results support a description-length explanation for the lack of overfitting in benchmark-driven ML: successful strategies occupy a low-complexity region of strategy space.

Martin Andres Bertran, Aaron Roth, Zhiwei Steven Wu

Amazon Responsible AI · University of Pennsylvania · Carnegie Mellon University

Minimum Description Length Benchmark Contamination Information Bottleneck Autonomous Research Agents

Jun 9, 2026cs.AI

Moonshine: An Autonomous Mathematical Research Agent Centered on Conjecture Generation

Moonshine is an autonomous agent whose central objective is to generate mathematical conjectures. Its core capability is to extract structure from classical problems, distill new concepts, and formulate conjectures of mathematical significance. Rather than treating the solution of a single proposition as its endpoint, Moonshine builds an extensible theoretical framework through conjecture generation, bridge building, and obstacle identification. This article uses Moonshine's exploration of the Jacobian conjecture as an example. It shows how the central logic of whether local nondegeneracy can force global injectivity is transferred to one-hidden-layer affine-ridge sigmoid networks. This leads to the formulation of the \emph{Neural Jacobian Conjecture} (NJC): if such a network has strictly positive Jacobian determinant on the whole space, then it must be globally injective. By invoking GPT-5.5-pro and DeepSeek-V4-pro separately, Moonshine obtained independent complete proofs for the case

N=n+1

. In addition, with the assistance of ChatGPT through interactive use of its web interface with GPT-5.5-pro, a geometric-topological proof was developed. These results provide preliminary evidence for the plausibility of the conjecture. The general higher-width case

N\ge n+2

, however, remains unresolved and is left for further investigation. This work illustrates Moonshine's ability to autonomously generate meaningful mathematical problems and make rigorous progress on them.

Xiaoyang Chen, Xiang Jiang

School of Mathematical Science, Tongji University · Moonshine Technology

Autonomous Research Agents

Jun 8, 2026cs.AI

SearchSwarm: Towards Delegation Intelligence in Agentic LLMs for Long-Horizon Deep Research

Large language models are increasingly expected to handle complex, long-horizon real-world tasks whose context demands can grow without bound, yet model context windows remain inherently finite. Recent work explores a paradigm where a main agent decomposes tasks and dispatches subtasks to subagents, which execute and return only summarized results, conserving the main agent's context budget. However, performing this well requires delegation intelligence: the ability to decompose complex tasks, determine when and what to delegate, and integrate returned results into the ongoing workflow. Training data for this capability is scarce in naturally occurring text, and to our knowledge, how to synthesize such data and train models to acquire this capability remains largely unexplored in the open-source community. To bridge this gap, we present a preliminary exploration targeting deep research, a representative long-horizon agent task. Specifically, we design a harness that guides the model toward high-quality task decomposition and delegation, while constraining subagents to return results properly to support the main agent's workflow. The harness-guided trajectories naturally encode correct delegation decisions, which we use as supervised fine-tuning data to internalize delegation intelligence into model weights. Our resulting model, SearchSwarm-30B-A3B, achieves 68.1 on BrowseComp and 73.3 on BrowseComp-ZH, the best results among all models of comparable scale. We will release our harness, model weights, and training data to facilitate future research.

Pu Ning, Quan Chen, Kun Tao +7

Tsinghua University · Peking University · Ant Group +1

Multi-Agent LLM Systems LLM Agent Orchestration LLM Agent Training Task Decomposition Long-Horizon LLM Agents Autonomous Research Agents

Jun 8, 2026cs.AI

MASS: Deep Research for Social Sciences with Memory-Augmented Social Simulation

Deep Research agents powered by Large Language Models (LLMs) have exhibited extraordinary potential in automated paper writing tasks. However, existing systems rely heavily on literature retrieval and synthesis through internet and local knowledge bases, often resulting research in lacking insight and creativity in social science. To address this issue, we propose "Memory-Augmented Social Simulation (MASS)", an innovative paradigm that leverages highly realistic and research-oriented social simulations to enhance the creativity and empirical founding of LLMs-generated research. Specifically, MASS integrates three core components: dynamic goal-path planning with multi-level social norm restraint to guide the simulation, a multi-disciplinary behavior dataset for agent memory cold-start, and a structured forgetting mechanism inspired by the Ebbinghaus curve. Together, these ensure simulation authenticity and provide a robust empirical foundation for generating innovative scholarly papers. Experimental results demonstrate the effectiveness of our method, showing a 6.81% improvement in generation overall quality over foundation LLMs and 17.19% gain in Insight over strong baselines.

Yongrui Liu, Deyi Xiong

The International Joint Institute of Tianjin University, Fuzhou, Tianjin University, China · TJUNLP Lab, School of Computer Science and Technology, Tianjin University, China

Human Behavior Simulation Large Language Model-Based Social Simulation Large Language Model-Guided Scientific Discovery Memory-Augmented Agents Autonomous Research Agents

Jun 7, 2026cs.LG

SkillHone: A Harness for Continual Agent Skill Evolution Through Persistent Decision History

Agent skills extend language-model agents with task-specific procedures, scripts, and references, but the tasks and environments they target continually change. Existing methods improve skills in bounded runs and retain only the final artifact, discarding the decision history that later agents need to interpret prior revisions, evaluations, and rejected alternatives. We introduce SkillHone, a harness for continual agent skill evolution grounded in persistent decision history. SkillHone pairs skill revisions with evaluation-side evidence that supplies practice feedback, recording structured histories of diagnoses, revisions, evidence, and outcomes. Role-separated subagents run candidate skills on practice probes with redacted reporting and propose revisions informed by prior decisions, enabling cross-session refinement without rediscovering past rationale. On deep-research benchmarks, SkillHone runs without a pre-integrated search stack and outperforms the commercially backed deep-research agent by 15.8 points on GAIA and 3.2 points on WebWalkerQA-EN, while also exceeding prior skill-evolution methods. We further deploy SkillHone on internal tool-mediated analysis scenarios, where it improves accuracy by an average of 18.8 points across seven settings.

Zhiwei Li, Yong Hu

WeChat AI, Tencent Inc., China · WeChat, Tencent Inc., China

Continual Learning for LLM Agents LLM Agent Skill Learning Memory-Augmented Agents Autonomous Research Agents