Deep Learning

The accurate classification of benign and malignant pulmonary nodules in CT scans is critical for early lung cancer screening, yet remains challenging due to the multi-scale and heterogeneous nature of pulmonary nodules. While deep learning offers potential for auxiliary diagnosis, most existing models act as "black boxes", lacking the transparency and explainability required for trustworthy clinical integration. To address this issue, we propose M3Net, a novel 3D network for pulmonary nodule classification inspired by the hierarchical diagnostic workflow of radiologists, which integrates multi-scale contextual information from fine-grained structures to global anatomical relationships. Our framework constructs a progressive multi-scale input, from fine-grained nodule structures to local semantics and global spatial relationships. M3Net employs scale-specific encoders and ensures cross-scale semantic consistency through latent space projection and mutual information maximization. Extensive experiments on the public LIDC-IDRI dataset and a self-collected clinical dataset (USTC-FHLN) demonstrate that our method achieves state-of-the-art performance, with accuracies of 86.96% and 84.24% respectively, outperforming the best baseline by 3.26% and 2.17%. The results validate that M3Net provides a more robust and clinically relevant solution for pulmonary nodule classification. The code is available at https://github.com/jylEcho/M3-Net.

Multi-window CT imaging captures complementary pathological information across anatomical structures of differing densities, yet existing deep learning methods fuse representations only at later stages, missing cross-density interactions. We propose a cross-window knowledge distillation framework in which student encoders learn latent clinical priors from a teacher trained on the most informative window. Evaluated retrospectively on three cohorts - COPD-CT-DF (n=719), RSNA PE (n=1,433), and an in-house CTEPD dataset (n=161) - distillation improved per-window AUC by 10.1-16.5 percentage points on COPD-CT-DF (0.75-0.81 to 0.90-0.94; all P<0.001), with ensemble AUC reaching 0.9960. Similar gains were observed on RSNA PE (0.80-0.83 to 0.90-0.92) and CTEPD (AUC 0.7481 vs. 0.6264). Cross-window distillation internalises pathological signatures invisible to supervised approaches, offering a generalisable solution for multi-window pulmonary CT analysis.

Diabetic Retinopathy (DR) is an art and science of recording and classifying the retinal images of a diabetic patient. DR classification deals with classifying retinal fundus image into five stages on the basis of severity of diabetes. One of the major issue faced while dealing with DR classification problem is the large and varying size of images. In this paper we propose and explore the use of several downscaling algorithms before feeding the image data to a Deep Learning Network for classification. For improving training and testing; we amalgamate two datasets: Kaggle and Indian Diabetic Retinopathy Image Dataset. Our experiments have been performed on a novel Multi Channel Inception V3 architecture with a unique self crafted preprocessing phase. We report results of proposed approach using accuracy, specificity and sensitivity, which outperform the previous state of the art methods. Index Terms: Diabetic Retinopathy, Downscaling Algorithms, Multichannel CNN Architecture, Deep Learning

Accurately modeling and designing protein complex structures is a central problem in computational structural biology, with broad implications for understanding cellular function and developing therapeutics. This thesis investigates two fundamental aspects of this problem using deep learning: domain-specific architectures that capture the hierarchical nature of protein structures, and search algorithms that efficiently navigate the vast sequence spaces of protein complexes to identify interacting homologs for improving complex structure prediction and to design protein sequences.

Deep learning has become the dominant approach for creating high capacity, scalable models across diverse data modalities. However, because these models rely on a large number of learned parameters, tightly couple feature extraction with task objectives, and often lack explicit reasoning mechanisms, it is difficult for humans to understand how they arrive at their predictions. Understanding what representations emerge and why they arise from the training data remains an open challenge. We introduce Deep Arguing, a novel neurosymbolic approach that integrates deep learning with argumentation construction and reasoning for interpretable classification with different data modalities. In our approach deep neural networks construct an argumentation structure wherein data points support their assigned label and attack different ones. Using differentiable argumentation semantics for reasoning, the model is trained end-to-end to jointly learn feature representation and argumentative interactions. This results in argumentation structures providing faithful case-based explanations for predictions. Structure constraints over the argumentation graph guide learning, improving both interpretability and predictive performance. Experiments with tabular and imaging datasets show that Deep Arguing achieves performance competitive with standard baselines whilst offering interpretable argumentative reasoning.

Deep neural networks achieve high accuracy on image classification tasks. Yet, they often produce overconfident predictions as which fail to express epistemic uncertainty, and frequently violate logical or structural constraints present in the data. These limitations are particularly pronounced in hierarchical classification, where predictions across fine and coarse levels must remain coherent. We propose, for the first time, a unified neurosymbolic and epistemic modelling framework that augments Swin Transformers with focal set reasoning and differentiable fuzzy logic. Rather than treating labels as isolated categories, our method induces data-driven focal sets within the learnt embedding space, which helps capture epistemic uncertainty over multiple plausible fine-grained classes. These focal sets form the basis of a belief-theoretic layer that uses fuzzy membership functions and t-norm conjunctions to encourage consistency between fine- and coarse-grained predictions. A learnable loss further balances calibration, mass regularisation, and logical consistency, allowing the model to adaptively trade off symbolic structure with data-driven evidence. In experiments on hierarchical image classification, our framework maintains accuracy on par with transformer baselines while providing more calibrated and interpretable predictions, reducing overconfidence and enforcing high logical consistency across hierarchical outputs. Our experimental results show that combining focal set reasoning with fuzzy logic provides a practical step toward deep learning models that are both accurate and epistemically aware.

Out-of-distribution (OOD) detection is essential for building reliable AI systems, as models that produce outputs for invalid inputs cannot be trusted. Although deep learning (DL) is often assumed to outperform traditional machine learning (ML), medical imaging data are typically acquired under standardized protocols, leading to relatively constrained image variability in OOD detection tasks. This motivates a direct comparison between ML and DL approaches in this setting. The two approaches are evaluated on open datasets comprising over 60,000 fundus and non-fundus images across multiple resolutions. Both approaches achieved an AUROC of 1.000 and accuracies between 0.999 and 1.000 on internal and external validation sets, showing comparable detection performance. The ML approach, however, exhibited substantially lower end-to-end latency while maintaining equivalent accuracy, indicating greater computational efficiency. These results suggest that for OOD detection tasks of limited visual complexity, lightweight ML approaches can achieve DL-level performance with significantly reduced computational cost, supporting practical real-world deployment.

Differentially private stochastic gradient descent (DP-SGD) is a standard approach to privacy-preserving learning based on per-example clipping, subsampling, Gaussian perturbation, and privacy accounting. Classical DP-SGD releases a noisy version of the current clipped subsampled gradient sum. We propose Fractional-Order Differentially Private Stochastic Gradient Descent (\textbf{FO-DP-SGD}), a mechanism-level extension that replaces this current-only query, before Gaussian noise is added, with a fractional recursive query combining the current clipped sum with a finite-window, power-law-weighted aggregation of previously released private sum-level outputs. This injects fractional memory into the release mechanism while preserving the standard \emph{sum-then-noise-then-divide} structure. Under add/remove adjacency with Poisson subsampling, the current-step sensitivity analysis shows that the only newly data-dependent term is the scaled current clipped sum. Hence, conditioned on the private history, the effective $\ell_2$-sensitivity is at most $βC$, where $C$ is the clipping threshold and $β\in(0,1]$ controls the current-step contribution. Thus, FO-DP-SGD admits standard per-step Rényi differential privacy accounting via a Poisson-subsampled Gaussian mechanism with effective noise-to-sensitivity ratio $σ/β$, and composes to yield overall $(\varepsilon,δ)$-differential privacy guarantees. FO-DP-SGD provides a framework for studying long-memory effects in private optimization. The fractional order, memory window, and mixing coefficient govern the trade-off among current-step sensitivity, signal retention, and private-history influence. Experiments on SVHN, CIFAR-10, and CIFAR-100 show improved test accuracy and privacy--utility performance over DP-SGD and private baselines including DP-Adam, DP-IS, SA-DP-SGD, ADP-AdamW, DP-SAT, and DP-Adam-AC.

Electrocardiogram (ECG) interpretation is essential for diagnosing a wide range of cardiac abnormalities. While deep learning has shown strong potential for automating ECG classification, many existing models rely on large, computationally intensive architectures that hinder practical deployment. In this paper, we present an empirical study of convolutional neural network (CNN) architectures, exploring tradeoffs between diagnostic accuracy and computational efficiency. We benchmark two established baselines: AttiaNet, a compact model composed of sequential temporal and spatial blocks, and DeepResidualCNN, the winning architecture of the 2021 PhysioNet/Computing in Cardiology Challenge. Building on these, we propose three lightweight models: (i) ParallelCNN, which employs dual temporal and spatial branches for parallel pattern extraction; (ii) ParallelCNNew, a variant with symmetric weight initialization for balanced feature learning; and (iii) SimpleNet, a streamlined architecture that jointly processes temporal and spatial dimensions. Our experiments span three publicly available 12-lead ECG datasets from Germany, China, and the United States, covering binary, multiclass, and multilabel classification tasks across diverse patient populations. We further evaluate the impact of integrating low-cost demographic metadata (age and sex) to improve performance with minimal overhead. To ensure fair comparison, we introduce a unified Efficiency Score that integrates model size, inference speed, memory usage, and AUC performance. By balancing diagnostic performance and efficiency, our models offer a scalable and viable foundation for next-generation AI systems in cardiovascular care.

While machine learning has revolutionized many fields such as natural language processing (NLP) and computer vision, its impact on time-series forecasting is still widely disputed, especially in the finance domain. This paper compares forecasting performance on U.S. Treasury yield curve data across econometrics/time-series analysis, classical machine learning, and deep learning methods, using daily data over 47 years. The Treasury yield curve is important because it is widely used by every participant in the bond markets, which are larger than equity markets. We examine a variety of methods that have not been tested on yield curve forecasting, especially deep learning algorithms. The algorithms include the Autoregressive Integrated Moving Average (ARIMA) model and its extensions, naive benchmarks, ensemble methods, Recurrent Neural Networks (RNNs), and multiple transformers built for forecasting. ARIMA and naive econometric models outperform other models overall, except in one time block. Of the machine learning methods, TimeGPT, LGBM and RNNs perform the best. Furthermore, the paper explores whether stationary or nonstationary data are more appropriate as input to deep learning models.

Multiple Sclerosis (MS) is a chronic autoimmune disease that can significantly reduce the quality of life of a patient. Existing treatment options can only help slow down the progression of the disease. Therefore, early detection and precise monitoring of disease progression are important. Deep learning offers state-of-the-art models for detecting and segmenting MS lesions in brain MRI scans. However, most of these models are evaluated using the Dice score, without accounting for lesion-wise detection and segmentation performance or other metrics that quantify model performance in cases that are complex or confusing for human annotators, or in cases that are essential for disease detection and progression monitoring. In this paper, we highlight the need to rethink the evaluation of MS lesion segmentation models. In this context, we first present problem fingerprinting in detail to highlight what neurologists look for in brain MRI scans for MS detection and progression monitoring, and which metrics are required to properly quantify model performance in these contexts. Additionally, we present an analysis of state-of-the-art models on two open-source datasets using these metrics to highlight their usability for real-world deployment in hospitals.

Rapid earthquake magnitude estimation is crucial for effective early warning systems that can save lives and reduce economic damage. In this paper, we present a comprehensive study of magnitude classification using only the vertical component of the initial 7-second P-wave window from a single station. We compare six machine learning approaches that range from traditional models to state-of-the-art deep learning architectures. We also curated a novel dataset of 7,318 earthquake events in South Asia. The dataset was categorized into five Richter-scale classes: slight (3.0-3.9), light (4.0-4.9), moderate (5.0-5.9), strong (6.0-6.9) and severe (>= 7.0). Our experiments show that deep learning models substantially outperform traditional approaches. Our Transformer based architecture achieved 76.23% standard accuracy and 81.56% adaptive accuracy with 4.8 ms inference latency. The adaptive-accuracy metric is introduced for the inherent uncertainty in magnitude estimation of near class boundaries. These results indicate that the attention mechanisms in Transformers combined with adaptive classification effectively capture the temporal dynamics of seismic signals. The architectural advantage facilitates promising generalization to rare high-magnitude events, despite the inherent data scarcity characteristic of seismic catalogs. The adaptive accuracy provides a more realistic assessment of model performance, and the result suggests viability for real-time deployment.

Prenatal germinal matrix-intraventricular hemorrhage (GMH-IVH) is a leading cause of infant mortality and neurodevelopmental impairment, yet its manual diagnosis and lesion segmentation on fetal brain MRI are labor-intensive and error-prone. Although supervised deep learning offers potential for automation, it typically requires large amounts of annotated GMH-IVH data, which are challenging to obtain for such a rare condition (0.5-0.9 per 1000 pregnancies). To address these problems, an annotation-free deep learning framework, FreeHemoSeg, was developed for automated detection and segmentation of GMH-IVH without any real patient annotations. Instead of learning from expert labels, FreeHemoSeg was trained on pseudo GMH-IVH images synthesized from normal fetal data guided by medical priors. The framework was evaluated in a retrospective multicentre study of 1,674 stacks of 2D T2-weighted MRI from 558 pregnant women, using data from one hospital for internal training and validation and two hospitals for external validation. FreeHemoSeg achieved the highest diagnostic and segmentation performance in both internal validation (AUROC: 0.959; AUPR: 0.928; sensitivity: 0.914; specificity: 0.966; DSC: 0.559) and external validation (AUROC: 0.930; AUPR: 0.884; sensitivity: 0.824; specificity: 0.943; DSC: 0.512), outperforming a supervised model trained on limited empirical data and unsupervised anomaly detection methods. Moreover, FreeHemoSeg assistance improved radiologists' sensitivity (from 0.882 to 0.941-1.000) and diagnostic confidence, while reducing interpretation time by 16.0-52.7%. We anticipate its immediate utility in supporting earlier diagnosis, prognostic counselling, and perinatal planning for fetal GMH-IVH. Code: https://github.com/Arktis2022/FreeHemoSeg.

Link prediction (inferring missing or future connections between nodes in a graph) is a fundamental problem in network science with widespread applications in, e.g., biological systems, recommender systems, finance and cybersecurity. The ability to accurately predict links has significant real-world applications, such as detecting fraudulent financial transactions or identifying drug-target interactions in biomedicine. Despite a rich literature, link prediction is still challenging, especially for graphs enriched with information on edges (direction) and nodes (attributes). In fact, research on link prediction, especially the one based on Graph Deep Learning (GDL), has mostly focused on undirected graphs, without fully leveraging node attributes. Here, we fill this gap by proposing Gravity-GraphSAGE (GG-SAGE), a modified version of GraphSAGE, a GDL model for node embeddings, composed of a gravity-inspired decoder. This implementation is the first example in the literature of a GraphSAGE backbone adopted for directed link prediction. Using the benchmark datasets Cora, Citeseer, PubMed and 16 real-world graphs from the online Netzschleuder repository, we show that our proposed model outperforms state-of-the-art GDL link prediction techniques. Using further experimental evidence, we relate the quality of the output of our model with various characteristics of the graph, suggesting that our framework scales well when applied to data of increasing complexity.

Although many complex models were proposed to analyze time series data, some studies have demonstrated remarkable performance with simpler structures. A recent study proposed a non-parametric framework for 3D point cloud classification, which has the potential to be adapted for time series forecasting and enable interpretability. Inspired by the previous works, we present TSNN, a non-parametric and interpretable framework for traffic time series forecasting. TSNN consists of multiple layers that decouple the time series by matching the entries in a memory bank, where the memory bank is constructed using a similar matching process within the training set. It leverages the periodicity in traffic data to enhance forecasting accuracy while maintaining a simple model architecture. The proposed model operates without trainable parameters, preserving its inherent interpretability. In the experiments, TSNN achieves competitive performance compared to the typical deep learning models in four real-world traffic flow datasets. We also visualize the decoupling process to show the effectiveness of the components. Finally, we demonstrate the interpretability of the model and illustrate the contribution of each time step within the memory bank.

Computer-Aided Design is ubiquitous in todays world, as almost every manufactured object begins as a digital model across industries. At the same time, advances in 3D sensing have made point clouds a dominant form of raw 3D data. Recovering the CAD model of a physical object from its point cloud scan has two major applications: reverse engineering, where physical or hand-crafted prototypes need to be reconstructed automatically as editable digital models, and quality control, where recovering the CAD description of a manufactured object helps quantify and understand deviations introduced during the production process. Thus, converting unordered point clouds into structured CAD models is increasingly important for modern applications. Deep learning has enabled major progress in computer vision for both 2D and 3D data, and new datasets facilitate data-driven CAD reconstruction. Building on this foundation, we develop an end-to-end model that reconstructs CAD models from point clouds and introduce a segmentation approach that decomposes them into individual extrusions. These partial shapes increase data diversity, improving the generalization and robustness of deep learning models. Our strategy thereby provides a simple, yet effective way to increase reconstruction performance of deep learning models.

Modern machine learning deployments increasingly compose specialized models into dynamic inference pipelines, where upstream components produce intermediate predictions that determine the workload and inputs of downstream components. The cost of processing an input is therefore not determined by any single model, but by two coupled factors: the per-inference cost of each invoked component and its workload volume. Because these pipelines run under hard real-time constraints, efficiency is a fundamental requirement for system availability. We show that this structure creates an efficiency-attack surface that existing methods targeting single models cannot exploit: on identical inputs and budgets, path-aware targeting inflates FLOPs by $2,407\times$ while the strongest single-model baseline achieves $117\times$ -- a $20\times$ gap attributable entirely to where the attack is directed. We formalize this as the adversarial path-selection problem and present AESOP, a framework combining vulnerability-guided path ranking with adaptive loss weighting. We evaluate AESOP on five pipelines plus a production-realistic deployment variant with batching, bounded buffering, and confidence-threshold defenses. AESOP achieves up to $2,407\times$ FLOPs and $419\times$ latency inflation in white-box setting and 58$\times$ FLOPs / 17$\times$ latency in gray-box settings. Under system-level defenses, the attack is not neutralized but redirected: pipelines are forced to choose between throughput collapse ($0.578 \to 0.006$ input/s) and $96.7\%$ data loss to sustain throughput.

Out-of-distribution (OOD) detection is essential for reliable deployment of deep learning systems, yet the majority of existing methods are evaluated on small, visually homogeneous benchmarks. In this work, we study six OOD detection methods spanning post-hoc scoring, auxiliary objectives, energy-based models, and constrained optimization on the Plant Pathology 2021 dataset, a fine-grained task with natural distribution shifts. Energy-based fine-tuning performs best across OOD settings, improving detection over the softmax baseline while preserving in-distribution accuracy. Analysis shows these gains stem from both a restructuring of the embedding space alongside calibration of the scoring function. We further document practical training instabilities that arise when scaling constrained optimization methods to moderate-sized datasets, findings that are largely absent from existing literature. Our results demonstrate that principled OOD detection is achievable on real-world domain-specific data and that benchmark evaluations alone may not capture the challenges that emerge in practice.

Modern deep learning treats neural networks primarily as endpoint functions from inputs to outputs. Inspired by the shift from force to geometry in physics, we ask whether a network should instead be understood through the geometry of its internal propagation. We define a neural propagation field as the collection of hidden-state trajectories and local Jacobian operators across depth. Endpoint losses constrain only the boundary behavior of this field, leaving its interior geometry underdetermined. We show that endpoint-equivalent models can differ by orders of magnitude in trajectory and Jacobian structure, and introduce observable field metrics such as path sensitivity, solver consistency, and trajectory/Jacobian retention. In controlled teacher-flow and PDE systems, endpoint fitting fails to recover the underlying propagation law. In real multi-path tasks, field-aware objectives improve unseen-path generalization, OOD robustness, and calibration when aligned with the observation structure, but can collapse when over-constrained. In continual learning, field-preservation regularization complements replay and distillation: on Split CIFAR-100, DER++ with field preservation improves average accuracy, backward transfer, and field-retention metrics. These results identify propagation-field quality as a measurable and trainable property of neural networks beyond endpoint performance.

The Hessian spectrum of trained deep networks exhibits a characteristic structure: a continuous bulk of near-zero eigenvalues and a small number of large outlier eigenvalues (spikes), confirming the relevance of Random Matrix Theory in deep learning. The spike count matches the number of classes minus one. While prior work has described this structure, no method has exploited it operationally to improve classification performance. We propose Hessian Surgery, a post-hoc optimization method that directly perturbs model weights along spike eigenvectors to rebalance per-class accuracy without retraining. We introduce (i) a spike-class sensitivity matrix that quantifies the directional derivative of each class's accuracy along each spike eigenvector, (ii) a constrained optimization of perturbation coefficients that targets weak classes while preserving strong ones, and (iii) an adaptive amplitude control that raises or lowers the perturbation budget based on iteration-level improvement signals. We obtain encouraging results on CIFAR-10 and ISIC-2019 on both balanced accuracy and standard deviation.

Modern deep models are often pretrained on large-scale data with missing labels using composite objectives, where the relative weights of multiple loss terms act as hyperparameters. Tuning these weights with random search or Bayesian optimization is computationally expensive, as it requires many independent training runs. To address this, we propose a gradient-based bilevel method that learns pretraining loss weights online by aligning the composite pretraining gradient with a downstream objective. By exploiting the structure of the loss, the method avoids the multiple backward passes typically required by truncated backpropagation through the full model, reducing the overhead of hyperparameter tuning to approximately 30% above a single training run. We evaluate the approach on event-sequence modeling and self-supervised computer vision, where it matches or improves upon carefully tuned baselines while substantially reducing the cost of hyperparameter tuning compared to random or Bayesian search.

Leveraging deep learning for causal discovery in time series remains challenging because existing neural methods predominantly rely on component-wise architectures that fail to capture shared system dynamics or employ decoupled post-hoc graph extraction that risks overfitting to spurious correlations. We propose $\textbf{Mask2Cause}$, an end-to-end framework that recovers the underlying causal graph directly during the forecasting forward pass. Our approach introduces an Inverted Variable Embedding and an Adjacency-Constrained Masked Attention mechanism, trained with homoscedastic or heteroscedastic objectives to capture causal influences in both mean and variance. Empirical results on diverse benchmarks, from synthetic chaotic dynamics to realistic biological simulations, demonstrate state-of-the-art causal discovery with significantly reduced parameter complexity compared to standard baselines. We further show that inferred causal structures can be used to reduce parameter count of forecasting models by more than 70% on average while maintaining predictive accuracy.

Many machine learning tasks are invariant under the action of a group $G$ of transformations: signal classification can be invariant under translations, image classification under 2D rotations, and spherical-image classification under 3D rotations. The $G$-bispectrum is a principled complete invariant of a signal (retaining all all signal's information up to the group action) with proven benefits in machine learning and as a pooling layer in deep networks. However, its deployment has been hampered by high computational cost and a patchwork of group-specific implementations. We present bispectrum, an open-source, fully unit-tested PyTorch library that implements selective $G$-bispectra for seven different group actions, as differentiable modules that can be directly incorporated into machine learning pipelines and deep learning architectures. For finite groups $G$, selectivity reduces the computational cost from $O(|G|^2)$ to $O(|G|)$. For planar rotations, we leverage the disk bispectrum. For spherical 3D rotations, we introduce an augmented selective bispectrum at band-limit $L$ which reduces the cost from $O(L^3)$ to $Θ(L^2)$ coefficients. We profile the entire library (for which we implemented various compute optimizations), showing that it delivers near-exact $G$-invariance with its selective $G$-bispectra computed in sub-millisecond time on GPU (up to commonly used bandlimits). We evaluate the benefits of incorporating $G$-bispectra as pooling layers into deep learning architectures on three classical benchmark datasets --comparing against norm pooling, gated pooling, Fourier-ELU pooling, max pooling, and (non-equivariant) data-augmented convolutional baselines. Results show that $G$-bispectra consistently outperform alternatives in the low-data, moderate-capacity regime.

Precise molecular subtyping of gliomas, including isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion, directly guides surgical and therapeutic decisions, yet currently relies on invasive tissue sampling. Deep learning on structural MRI has emerged as a non-invasive alternative, but anatomy-only approaches cannot capture the hemodynamic signatures that distinguish molecular subtypes. Radiogenomics based on dynamic susceptibility contrast (DSC) MRI holds immense potential for non-invasively characterizing glioma molecular subtypes, yet clinical deployment has been hindered by inter-site variability and the limitations of voxel-wise analysis. We introduce HiPerfGNN, a framework that first learns discrete hemodynamic representations from raw time-intensity curves using a vector-quantized variational autoencoder (VQ-VAE). These quantized perfusion codes define coarse-level graph nodes representing functional tumor habitats, each of which is hierarchically subdivided into fine-level subregions guided by structural MRI. A hierarchical graph neural network then propagates information across scales for molecular prediction. On an internal cohort (n=475), the model achieved AUCs of 0.96 (IDH), 0.89 (1p/19q), and 0.84 (WHO grade), and maintained robust IDH performance (AUC 0.89) on an independent external cohort (n=397) without recalibration. Gradient-based saliency analysis confirms biologically grounded attention patterns aligned with known glioma pathophysiology. Our results demonstrate the added value of integrating perfusion dynamics into radiogenomic pipelines for glioma molecular subtyping. Code is available at https://github.com/janghana/HiPerfGNN.

This paper presents CARMEN, a runtime-adaptive, CORDIC-accelerated multi-precision vector engine for resource-efficient deep learning inference. The key insight is that CORDIC iteration depth directly governs computational accuracy, enabling dynamic switching between approximate and accurate execution modes without hardware modification. The architecture integrates a low-resource iterative CORDIC-based MAC unit with a time-multiplexed multi-activation function block, supporting flexible 8/16-bit precision and high hardware utilization. ASIC implementation in 28 nm CMOS achieves up to 33% reduction in computation cycles and 21% power savings per MAC stage; a 256-PE configuration delivers 4.83 TOPS/mm2 compute density and 11.67 TOPS/W energy efficiency. FPGA deployment on PynqZ2 validates 154.6 ms latency at 0.43 W for real-time object detection.

Despite an ever-increasing interest in topological deep learning models that target higher-order datasets, there is no consensus on how to evaluate such models. This is exacerbated by the fact that topological objects permit operations, such as structural refinements, that are not appropriate for graph data. In this work, we extend MANTRA, a benchmark dataset containing manifold triangulations, to a larger class of manifolds with more diverse homeomorphism types. We show that, unlike prior claims, both graph neural networks (GNNs) and higher-order message passing (HOMP) methods can saturate the benchmark. However, we find that this is contingent on the right representation and feature assignment, emphasizing their importance in baseline models. We thus provide a novel evaluation protocol based on representational diversity and triangulation refinement. Surprisingly, we find no indication that existing models are capable of generalizing beyond the combinatorial structure of the data. This points towards a research gap in developing models that understand topological structure independent of scale. Our work thus provides the necessary scaffolding to evaluate future models and enable the development of topology-aware inductive biases.

Modern deep learning architectures increasingly contend with sophisticated signals that are natively infinite-dimensional, such as time series, probability distributions, or operators, and are defined over irregular domains. Yet, a unified learning theory for these settings has been lacking. To start addressing this gap, we introduce a novel convolutional learning framework for possibly infinite-dimensional signals supported on a manifold. Namely, we use the connection Laplacian associated with a Hilbert bundle as a convolutional operator, and we derive filters and neural networks, dubbed as \textit{HilbNets}. We make HilbNets and, more generally, the convolution operation, implementable via a two-stage sampling procedure. First, we show that sampling the manifold induces a Hilbert Cellular Sheaf, a generalized graph structure with Hilbert feature spaces and edge-wise coupling rules, and we prove that its sheaf Laplacian converges in probability to the underlying connection Laplacian as the sampling density increases. Notably, this result is a generalization to the infinite-dimensional bundle setting of the Belkin & Niyogi \cite{BELKIN20081289} convergence result for the graph Laplacian to the manifold Laplacian, a theoretical cornerstone of geometric learning methods. Second, we discretize the signals and prove that the discretized (implementable) HilbNets converge to the underlying continuous architectures and are transferable across different samplings of the same bundle, providing consistency for learning. Finally, we validate our framework on synthetic and real-world tasks. Overall, our results broaden the scope of geometric learning as a whole by lifting classical Laplacian-based frameworks to settings where the signal at each point lives in its own Hilbert space.

Vacuity, or Uncertainty Mass (UM), is commonly used as a metric to evaluate Out-of-Distribution (OOD) detection in Evidential Deep Learning (EDL). It generally involves dividing the number of classes ($K$) by the total strength of belief ($S$) of the model's predictions, where $S$ is derived from summing the Dirichlet parameters. As such, UM is sensitive to the cardinality of $K$. In particular, it is unlikely in practice that there is a linear relationship between $K$ and $S$ as $K$ and $S$ increase due to the nature of EDL (suppressing incorrectly assigned evidence). As a result, when comparing In Distribution (ID) and OOD results, it is important that $K_{\mathrm{ID}}$ and $K_{\mathrm{OOD}}$ are equal; something that is not always ensured in practice. We provide an empirical demonstration of how results for AUROC and AUPR can substantially differ when class cardinality between ID and OOD differs by 1, with AUROC differing by as much as 0.318 and AUPR by 0.613 for standard EDL, and AUROC by 0.360 and AUPR by 0.683 for IB-EDL. More concretely, our findings isolate an evaluation artefact: when K differs between ID and OOD, AUROC/AUPR can be artificially inflated without any change in model predictions. We further discuss the evaluation of EDL over causal language models using Multiple-Choice Question-Answer (MCQA) datasets and argue for clearer definitions of ID and OOD in this context. Our primary contribution is an empirical and theoretical demonstration that vacuity-based OOD detection in EDL-fine-tuned LLMs is highly sensitive to uncontrolled differences in evaluated class cardinality.

Cocoa (Theobroma cacao) is a critical cash crop for millions of smallholder farmers in West Africa, where Cocoa Swollen Shoot Virus Disease (CSSVD) and anthracnose cause devastating yield losses. Automated disease detection from leaf images is essential for early intervention, yet deploying such systems in resource-constrained settings demands models that are small, fast, and require no internet connectivity. Existing edge-deployable plant disease systems rely on end-to-end deep learning without uncertainty quantification, while Bayesian methods for edge devices focus on hardware-level inference architectures rather than agricultural applications. We bridge this gap with TinyBayes, the first framework to combine a closed-form Bayesian classifier with a mobile-grade computer vision pipeline for crop disease detection. Our pipeline uses YOLOv8-Nano (5.9 MB) for lesion localisation, MobileNetV3-Small (3.5 MB) for feature extraction, and the Jacobi prior; a Bayesian method that provides a closed form non-iterative estimators via projection, for the classification. The Jacobi-DMR (Distributed Multinomial Regression) classifier adds only 13.5 KB to the pipeline, bringing the total model size within 9.5 MB, while achieving 78.7% accuracy on the Amini Cocoa Contamination Challenge dataset and enabling end-to-end CPU inference under 150 ms per image. We benchmark against seven classifiers including Random Forest, SVM, Ridge, Lasso, Elastic Net, XGBoost, and Jacobi-GP, and demonstrate that the Jacobi-DMR offers the best trade-off between accuracy, model size, and inference speed for edge deployment. We have proved the asymptotic equivalence and consistency, asymptotic normality and the bias correction of Jacobi-DMR. All data and codes are available here: https://github.com/shouvik-sardar/TinyBayes

Accurate sleep stage classification across datasets remains challenging due to variability in EEG channel montages, sampling rates, recording environments, and subject populations. Although deep learning has shown considerable promise for automated sleep staging, most existing cross-dataset methods rely on one-dimensional EEG signal representations, whereas the use of two-dimensional spectrogram-based inputs within an unsupervised domain adaptation framework has remained largely unexplored. Here, we propose STDA-Net (Spectrogram-based Temporal Domain Adaptation Network), a framework that combines a convolutional neural network (CNN) for spectrogram-based feature extraction, a bidirectional long short-term memory (BiLSTM) module for temporal modeling of sleep dynamics, and a domain-adversarial neural network (DANN) for source-to-target feature alignment without requiring any labeled target-domain data during training. Experiments are conducted on three publicly available datasets Sleep-EDF, SHHS-1, and SHHS-2 under six cross-dataset transfer settings. Results show that the proposed framework achieves an average accuracy of 89.03% and an average macro F1-score of 87.64%, consistently outperforming existing 1D baseline methods in terms of balanced classification performance, with substantially lower variance across five independent runs, indicating improved stability and reproducibility. Overall, these findings demonstrate that 2D spectrogram-based representations, combined with temporal modeling and adversarial domain adaptation, provide a robust and competitive alternative to conventional 1D EEG inputs for cross-dataset sleep staging.

Synthetic data has transformed language model training, yet its role in time series forecasting remains poorly understood. We present a large-scale empirical study: nine experiment groups, 4,218 runs systematically evaluating synthetic time series augmentation across five architectures, four synthetic signals and seven datasets. The effect is sharply architecture-conditional: channel-mixing models (TimesNet, iTransformer) benefit in the majority of trials, while channel-independent models (DLinear, PatchTST) are consistently degraded. In selected low-resource settings the gains are striking: TimesNet trained on only 10% of Weather data with synthetic augmentation surpasses the full-data baseline (4 of 16 sparsity-dataset combinations). Averaged across all architectures, augmentation hurts in 67% of trials. We further find that only the Seasonal-Trend generator reliably helps across the tested benchmarks, and that hard curriculum switching is actively harmful (+24% MSE degradation). These results provide concrete, actionable guidelines on how to use synthetic data: use synthetic augmentation with channel-mixing architectures, use gradual annealing schedules, and treat low-resource augmentation as architecture- and dataset-dependent. Code is available at \href{https://github.com/hugoiscracked/synthetic-ts/tree/main}

In the mid-twentieth century, mathematician and polymath John von Neumann created a computational system on an array of cells as a simple model of the human brain, where each cell had one of a finite set of roles or states that he predicted would be modelled by a diffusion process. In this work, we show that such a system, when developed in a modern deep learning setting, enables the construction of an artificial neuron having specialized roles that can be learnt. We refer to this neuron as the Von Neumann neuron, and the resulting neural network from such neurons result in a self-engineered design whose architecture is only dependent on the structure and locations of its inputs and outputs on this cellular array. The mathematical framework for these Von Neumann Networks (VNNs) is also constructed and shows that they are based on the extension of neural operators and the learning of Green's functions with convolutions on a cellular topology having a diffusion signature. We also prove that these VNNs are part of a more general computational system called Cellular Machines that are computationally universal. Initial experiments show that VNN based multi-layered perceptrons outperform their equivalent deep learning variant on basic tasks, while being more parameter efficient and are capable of learning new types of tasks. This includes the ability to solve for and construct an extension of the Von Neumann (hardware) architecture common to all modern computers to cells and suggests new opportunities that could be explored.

Knee osteoarthritis (KOA) is among the musculoskeletal disorders that considerably restrict joint mobility, cause severe chronic pain and impact negatively on quality life. It is one of the persistent health issues worldwide. Generally, subjectivity and inter-observer variability undermine conventional practices and evaluation process that are adopted to address such health issues. Hence precise and timely diagnosis would be one of the effective ways for the assessment of its severity. This paper proposes an automated diagnostic approach for severity grading of KOA by blending a deep learning convolutional neural network (CNN) with a device-based inference platform powered by TensorFlow Lite. It proposes a model based on the ResNet-18 convolutional neural network. The designed model is trained on publicly available database. Through a transfer learning approach obtained knee images are first classified into five Kellgren-Lawrence (KL) grades. Further the developed model is optimised. During the training of the model test accuracy of 94.48% with stable convergence has been achieved. Subsequently the optimised model transformed into a lightweight TensorFlow Lite format, facilitating seamless deployment on resource-constrained devices. The designed model is capable enough to operate in the environment having no continuous internet connectivity. Also, an auxiliary Large Language Model (Gemini-2.0-flash) is applied to generate structured interpretive findings like potential symptoms, risk factors, and preventive majors etc. The LLM component functions as interface without influencing the classification process. The proposed model articulates the feasibility of an on-device, interpretable decision-support tools for early diagnosis and improve accessibility to Artificial Intelligence (AI)-assisted knee screening tool.

Edge deep learning, a paradigm change reconciling edge computing and deep learning, facilitates real-time decision making attuned to environmental factors through the close integration of computational resources and data sources. Here we provide a comprehensive review of the current state of the art in edge deep learning, focusing on computer vision applications, in particular medical diagnostics. An overview of the foundational principles and technical advantages of edge deep learning is presented, emphasising the capacity of this technology to revolutionise a wide range of domains. Furthermore, we present a novel categorisation of edge hardware platforms based on performance and usage scenarios, facilitating platform selection and operational effectiveness. Following this, we dive into approaches to effectively implement deep neural networks on edge devices, encompassing methods such as lightweight design and model compression. Reviewing practical applications in the fields of computer vision in general and medical diagnostics in particular, we demonstrate the profound impact edge-deployed deep learning models can have in real-life situations. Finally, we provide an analysis of potential future directions and obstacles to the adoption of edge deep learning, with the intention to stimulate further investigations and advancements of intelligent edge deep learning solutions. This survey provides researchers and practitioners with a comprehensive reference shedding light on the critical role deep learning plays in the advancement of edge computing applications.

Deep learning systems are known to exhibit implicit regularization (alt. implicit bias), favoring simple solutions instead of merely minimizing the loss function. In some cases, we can analytically derive the implicit regularization -- connecting it to an equivalent penalty that augments the learning objective. However, modern deep learning systems are complex, carrying modifications to the training procedure and architecture (e.g. early stopping, minibatching, dropout) whose effects are not always directly interpretable. Although estimating the resulting implicit regularization could aid theorists in algorithm design and practitioners in interpreting their hyperparameter choices, this problem has received little direct attention. It is also tractable: regularization makes weight updates deviate from loss gradients, promising a signal for identifying implicit bias. Here we provide gradient matching methods that can be used to empirically estimate the implicit regularization. Our method works on networks with known regularization, recovering popular explicit penalties like $\ell_1$ and $\ell_2$. It also replicates known implicit effects, like the quadratic weight penalty induced by early stopping in gradient descent, demonstrating that it can be used to test theories of implicit regularization. Crucially, because our method is empirical, it can handle implicit regularization in arbitrary networks. We demonstrate this use by characterizing the effects of dropout in deep networks, showing implicit $\ell_2$ effects in this popular method. Our work shows that practitioners can use gradient matching to understand regularization in networks with implicit biases that are too complicated to derive analytically.

Drug discovery seeks molecules (ligands) that bind strongly and selectively to a target protein. However, fewer than 5% of candidate ligands pass the bar for even the early stages of drug discovery. Furthermore, we want methods that work for novel proteins for which we have no prior data. Starting from scratch, we have to iteratively select and test candidate ligands such that we find enough ligands of the desired quality in as few tests as possible. Our proposed algorithm, named SPADE, introduces a novel approach to ligand selection that requires only 40 tests on average to find 10 high-quality ligands. In one-vs-one comparisons, SPADE outperforms deep learning and Bayesian optimization methods on more proteins, achieving median improvements of 7%-32% in sample efficiency. SPADE is also 10x faster than its closest competitor at scoring candidate drugs. Dataset and code is available at https://anonymous.4open.science/r/SPADE_Fast_Drug_Discovery_by_Learning_from_Sparse_Data-F028/README.md

We externally validated three deep learning models (DenseNet121, ViT-B/32, and ResNet50) for predicting mammographic breast density from breast ultrasound exams on an independent cohort. The external validation set comprised 2,000 ultrasound exams, including 500 cancer cases defined by an initial negative exam (BI-RADS 1 or 2) followed by a cancer diagnosis within 6 months to 10 years, and 1,500 negative controls matched by manufacturer and study year. Performance was measured using patient-level AUROC across four density categories: A (fatty), B (scattered), C (heterogeneous), and D (extremely dense). As a downstream assessment, we also evaluated 10-year risk prediction by incorporating age and AI-derived density into the Tyrer-Cuzick model and comparing performance against a reference model using age and mammography-reported density. All three models performed best in extremely dense breasts (AUROC 0.868-0.899), with strong performance in fatty (0.814-0.838) and scattered density (0.764-0.799), and lower performance in heterogeneously dense breasts (0.699-0.729). DenseNet121 achieved the highest overall performance (micro-averaged AUROC 0.885), and performance across categories was comparable between internal and external testing. For risk modeling, age combined with AI-derived density yielded a lower AUROC than age combined with mammography-reported density (0.541 vs. 0.570; p = 0.23), with no statistically significant difference. These findings indicate that deep learning models generalize well to external data with different racial composition for breast density assessment. While performance is strongest in extremely dense breasts, heterogeneously dense remains more challenging, highlighting the need for targeted optimization.

Localization in 5G and 6G networks is essential for important use cases such as intelligent transportation, smart factories, and smart cities. Although deep learning has enabled improving localization accuracy, depending on the deployment scenario and the effort required for dataset collection campaigns on a given infrastructure, the training process for localization models can vary significantly. Furthermore, with respect to feature selection, recent works have demonstrated the robustness of angle-of-arrival (AoA) based localization. In view of these two points, we propose an adaptive framework for AoA-based localization that consists of two alternative learning strategies, each suited either for large or small training datasets. The proposed framework is evaluated on a real, massive multiple input multiple output (mMIMO) orthogonal frequency division multiplexing (OFDM) outdoor channel state information (CSI) dataset. First, we investigate offline learning when large training datasets are available; we propose a hierarchical framework that first distinguishes between line of sight (LoS) and non line of sight (NLoS) regions and then moves to more fine grained localization in the respective region. This approach provides high-performance localization through accumulated batch retraining and an integrated hyperparameter optimization mechanism. Second, when only a small training dataset is available, an online learning framework is proposed, using incremental tree-based and ensemble-based models for handling streaming data and continuously updating mode, as well as an online few-shot learning model for rapidly initializing new classes from a limited labeled support set. These results showcase that highly accurate robust localization can be achieved incrementally during network operation by exploiting online learning, alleviating the need for large dataset collection campaigns.

Recent deep learning approaches seek to automate CAD creation by representing a model as a sequence of discrete commands and parameters, and then generating them using autoregressive models or continuous diffusion operating in Euclidean embedding space. However, continuous diffusion perturbs representations in a continuous Euclidean domain that does not reflect the inherently discrete and heterogeneous nature of CAD tokens, often producing perturbed representations that map to semantically invalid symbols. To overcome this limitation, we propose a cascaded discrete diffusion framework for CAD generation, which consists of a command diffusion for generating CAD commands and a parameter diffusion conditioned on CAD commands. Unlike isotropic Gaussian perturbation, the forward process of our approach operates directly over categorical token distributions using delicate transition matrices. For commands, we adopt an absorbing-state transition matrix that progressively corrupts tokens to a designated symbol; for parameters, we introduce specific transition matrices tailored to heterogeneous attributes: a Gaussian kernel for coordinate continuity, a scale-invariant kernel for dimensional values, and a prior-preserving kernel for boolean attributes. The reverse process is achieved by two denoising networks: a Transformer-based encoder for command recovery, and a parameter network with extra local self-attention for command-level interaction and cross-attention for conditional injection. Experiments on the DeepCAD dataset show that the proposed approach surpasses existing autoregressive and continuous diffusion models on unconditional generation metrics, while qualitative results validate effective controllability in conditional generation tasks. Source codes will be released.

Plant breeding underpins global food security through incremental, accumulating improvements in crop yield, quality and sustainability, achieved via repeated cycles of crop ranking, selection and crossing. Climate change disrupts this process by altering local growing conditions, thereby shifting the relative performance of crop genotypes. Predicting these relative changes in yield is critical for food security. Yet, this problem remains an open challenge in plant breeding, and relatively unexplored within the AI community. We propose MixINN, an approach that first isolates high-quality genotype-environment interaction labels using mixed models, and then predicts these interactions for new crop varieties in future environmental conditions with a deep neural network. We evaluate our method on a corn multi-environment trial across the continental United States and show improved prediction of genotype ranking over current plant breeding methods. MixINN demonstrated superior performance in identifying the 20% most productive corn genotypes, leading to a 5.8% higher average yield, which further improved to 7.2% when targeting specific growing environments. These are competitive results for real-world breeding programs, demonstrating the potential of AI research in accelerating the development of climate-adapted crops, and improving future food security under climate change.

Modeling the dynamics of non-stationary stochastic systems requires balancing the representational power of deep learning with the mathematical transparency of classical models. While classical Markov transition operators provide explicit, theoretically grounded rules for system evolution, their empirical estimation collapses due to severe data sparsity when applied to high-resolution, high-noise environments. We explore this statistical barrier using financial time series as a canonical, real-world testbed. To overcome the degeneracy of empirical counting, we introduce a framework that utilizes neural networks strictly as parameterization engines to generate explicit, time-varying Markov transition matrices. By constraining the neural network to output its predictions as a formal stochastic operator, we maintain complete structural interpretability. We demonstrate that these learned operators successfully capture complex regime shifts: the state-conditioned model achieves mean row heterogeneity $\barρ = 0.0073$ while the state-free ablation collapses to exactly zero, and operator row entropy correlates with realized variance at $r = -0.62$ ($p \approx 10^{-251}$), revealing that high-volatility regimes homogenize transition dynamics rather than diversify them. Furthermore, rather than enforcing the Chapman-Kolmogorov equations as a rigid structural requirement, we repurpose them as a localized diagnostic tool to pinpoint specific temporal windows where first-order memory assumptions break down. Ultimately, this framework demonstrates how neural networks can be constrained to make rigorous, classical operator analysis viable for complex real-world time series.

Mechanical equipment forms the critical backbone of modern industrial production, yet domain shift severely limits the generalization of deep learning based fault diagnosis models across different equipment and operating conditions.Inspired by the success of foundation models in achieving zero-shotgeneralization, we propose YOTOnet (You Only Train Once), a novel architecture specifically designed for cross-domain fault diagnosis in mechanical equipment.YOTOnet comprises three core components: (1) a physics-aware Invariant Feature Distiller that extracts domain-agnostic representations using multi-scale dilated convolutions and FFT-based time-frequency fusion,(2) Domain-Conditioned Sparse Experts (DC-MoE) that adaptively route inputs to specialized processors via learned gating without external meta-data, and (3) a dual-head classification system with auxiliary supervision.Extensive validation on five public bearing datasets (CWRU, MFPT, XJTU,OTTAWA, HUST) through 30 cross-dataset protocols demonstrates the superiority of YOTOnet compared with other state-of-the-art methods. Critically, we observe a clear scaling effect-average test F1 improves from 0.5339(1 training dataset) to 0.705 (4 datasets), with a clear gain when moving from 3 to 4 datasets. These findings provide empirical evidence that foundation model principles can enable robust, train-once deployment for industrial fault diagnosis.

We introduce a unified theoretical framework for the rigorous analysis and systematic construction of deep neural networks (DNNs). This framework addresses a gap in existing theory by explicitly modeling the structure of tensor operations -- lower level information that is often abstracted. Our framework enables two novel objectives: (1) analysis of the evolution of architectural complexity over deep learning history, and (2) automatic construction of novel architectures based on new types of tensor operations. Our study of DNNs introduced over the past 40 years reveals a connection between groundbreaking architectures and increases in different types of architectural complexity. Moreover, we identify several large classes of higher complexity architectures that have not yet been explored. We then collect a dataset of 3,000+ higher complexity architectures, which we publicly release at: https://github.com/combinatoriallabs/ArchitecturalComplexity.

Cardiovascular disease remains the leading cause of death globally, underscoring the need for effective, accessible monitoring solutions, particularly through wearable devices that enable continuous, real-time tracking of heart rhythms in home settings. However, deploying deep learning models trained on clinical electrocardiogram (ECG) datasets to wearable devices remains challenging, as differences in recording equipment, signal quality, and patient populations introduce domain shifts that degrade model performance. We propose a hybrid transformer model that processes continuous ECG signals alongside seven heart rate variability (HRV) features, where the raw signal path captures beat-level morphological patterns and the HRV path encodes rhythm regularity statistics, allowing the model to jointly leverage complementary information from both representations. To enhance the model's ability to generalize across domains, we employ representation learning techniques, including Maximum Mean Discrepancy (MMD), a non-parametric kernel-based metric that quantifies the distance between feature distributions of different domains, to align feature distributions between source and target domains, addressing the challenge of domain shifts between public datasets and wearable device data. By leveraging five public ECG datasets for training, the model learns robust, generalized representations that mitigate domain-specific biases. When tested on wearable device data with an unseen domain, the model achieved an F1-macro 95% and balanced accuracy of 96.15%. These results demonstrate minimal performance degradation, with only a 2% drop in F1-macro compared to seen-domain evaluation, highlighting the model's generalization capabilities and its potential for reliable, real-time heart monitoring applications in home and ambulatory settings.

Mirroring its ubiquity in popular media and all human activities, the use of deep learning (DL) is rapidly growing in scientific imaging modalities. However, unlike everyday RGB pictures, pixels encode precise physicochemical properties in scientific imaging across potentially thousands of channels. While DL is well validated on human-centric RGB perceptual tasks, its effectiveness for scientific imaging remains uncertain. Here, we show that the naive application of DL frameworks to scientific images can lead to critical failures. We evaluate the use of DL for pathology, comparing RGB images of stained tissue with the quantitative and information-rich biochemical signatures of infrared (IR) imaging. Despite this informational advantage, DL models trained on IR data paradoxically underperform. We investigate this discrepancy to find that IR data priors interact poorly with the simplicity bias of DL, causing models to collapse to one-dimensional predictions. This constitutes a catastrophic DL failure because the model's representational capacity remains largely unused, while furthermore raising AI safety concerns and undermining the advantages of such scientific modalities. Notably, this problem persists even with state-of-the-art DL robustification strategies, which are primarily designed and validated for RGB imagery and thus inherit the same prior-bias mismatch. This work establishes a framework for understanding the limitations of generic DL in science and advocates for the study of modality-specific failure modes to guide the development of specialized, safe AI algorithms.

Geometry-aware optimizers such as Newton and natural gradient can improve conditioning in deep learning, but scalable variants such as K-FAC, Shampoo, and related preconditioners usually impose structural approximations early, often discarding cross-layer interactions induced by the network computation. We introduce Layerwise LQR (LLQR), a framework for learning structured inverse preconditioners under a global layerwise optimal-control objective. The starting point is an exact equivalence: the steepest-descent step under a broad class of divergence-induced quadratic models--including Newton, Gauss-Newton, Fisher/natural-gradient, and intermediate-layer metrics--can be written as a finite-horizon Linear Quadratic Regulator (LQR) problem. This formulation serves as a reference that exposes the layerwise dynamics and cost matrices encoding the original dense geometry. We then derive a scalable relaxation that learns diagonal, (E-)Kronecker-factored, or other structured inverse preconditioners by minimizing the LQR objective and reusing them across iterations. The resulting optimizer wraps standard methods while retaining a principled connection to second-order geometry, without forming or inverting the global curvature matrix. Experiments on ResNets and Transformers show that LLQR improves optimization dynamics and often translates these gains into improved final test performance, while adding only modest wall-clock overhead. It establishes LLQR as a practical framework for geometry-aware second-order methods and a reference for evaluating scalable approximations.

Recent natural disasters have highlighted the urgent need for efficient data-driven approaches to disaster management. Machine learning (ML) and deep learning (DL) techniques have shown considerable promise in enhancing the key phases of disaster management including mitigation, preparedness, detection, response, and recovery. A critical enabler of successful ML or DL based applications in remote sensing, however, is the accessibility and quality of annotated datasets. With the growing availability of high-resolution imagery from unmanned aerial vehicles (UAVs) and satellites, computer vision and remote sensing algorithms have become essential tools for rapid detection, situational assessment, and decision-making in disaster scenarios. This survey provides a comprehensive overview of publicly available image-based datasets relevant to ML/DL-based disaster management pipelines. Emphasis is placed on datasets that support computer vision and remote sensing tasks across all phases of disaster events including pre-disaster, during, and post-disaster. The goal of this work is to serve as a centralized reference for researchers and practitioners seeking high-quality datasets for rapid development and deployment of remote sensing-driven disaster response solutions.

Tools from random matrix theory have become central to deep learning theory, using spectral information to provide mechanisms for modeling generalization, robustness, scaling, and failure modes. While often capable of modeling empirical behavior, practical computations are limited by matrix size, often imposing a restriction to models that are too small to be realistic. This motivates the inference of properties of larger models from the behavior of smaller ones. Free decompression (FD) is a recently proposed method for extrapolating spectral information across matrix sizes, but its utility is currently limited by strong assumptions that preclude its implementation on more realistic machine learning (ML) models. We use algebraic spectral curve theory to provide a general FD methodology for spectral densities whose Stieltjes transform satisfies an algebraic relation, a modeling assumption that is more likely to hold in practice. This recasts FD as an evolution along spectral curves which can be readily integrated. Our framework enables the expansion of spectral densities that have multiple or multi-modal bulks, that exist at multiple scales, and that contain atoms, all characteristic of real-world data and popular ML models. We demonstrate the efficacy of our framework on models of interest in modern ML, including Hessian and activation matrices associated with neural networks and large-scale diffusion models.

The rapid growth of electronic communication has necessitated more robust systems for email classification and sentiment detection. This study presents a comparative performance analysis between traditional machine learning algorithms and deep learning architectures, specifically focusing on Support Vector Machines (SVMs), Logistic Regression, Naive Bayes, and Long Short-Term Memory (LSTM). Utilizing Word2Vec embeddings for feature representation, our experimental results indicate that the SVM model with a linear kernel achieves the highest efficiency and accuracy, reaching a peak performance of 98.74%. While the LSTM model demonstrates exceptional recall capabilities in detecting spam-related sentiments, it requires significantly more computational time compared to discriminative statistical models. Detailed evaluations via confusion matrices further reveal that traditional classifiers remain highly robust for dense vector spaces. This research concludes that for email detection tasks, SVM offers the most optimal balance between predictive precision and processing speed. These findings provide critical insights for developing high-performance automated email filtering systems in professional and academic environments.

Medical image super-resolution (MedSR) is essential for improving diagnostic precision across diverse imaging modalities such as MRI, CT, X-ray, Ultrasound, and Fundus imaging. Despite rapid advances in deep learning, challenges remain in preserving anatomical accuracy, maintaining perceptual quality, and generalizing across medical domains. This paper presents MedSR-Vision, a novel unified deep learning framework for evaluating and comparing super-resolution models across five modalities: Brain MRI, Chest X-ray, Renal Ultrasound, Nephrolithiasis CT, and Spine MRI, at magnification scales of $\times2$, $\times3$, and $\times4$. Three representative models namely SRCNN, SwinIR, and Real-ESRGAN are benchmarked using multiple quantitative metrics encompassing fidelity, perceptual realism, and sharpness. Experimental analysis demonstrates that Real-ESRGAN achieves superior perceptual quality and edge recovery at higher scales, SwinIR excels in preserving structural and diagnostic features, and SRCNN provides efficient and stable performance at lower magnifications. The results establish domain-specific insights and practical guidelines for model selection in clinical imaging workflows, offering a standardized evaluation framework for future medical image super-resolution research and deployment.

Evaluating canine electrocardiograms (ECGs) is challenging due to noise that can obscure clinically relevant cardiac electrical activity. Common sources of interference include respiration, muscle activity, poor lead contact, and external electrical artifacts. Classical signal denoising techniques, such as filtering and wavelet-based methods, struggle to suppress diverse noise patterns while preserving morphological features critical for accurate ECG delineation. We propose an autoencoder-based neural network model and training strategy for ECG denoising as a preprocessing step for canine ECG analysis. The model is trained to reconstruct clean cardiac signals from noisy inputs, enabling effective noise reduction without degrading diagnostically important waveforms. Our approach demonstrates strong performance across both noisy and clean ECG recordings, indicating robustness to varying signal conditions and suitability for downstream delineation tasks.

Automated culprit identification in surveillance systems is a critical task that requires high accuracy along with computational efficiency for real-time deployment. In this paper, an optimized deep learning framework is proposed using a lightweight MobileNet architecture integrated with channel and spatial attention mechanisms. The proposed model enhances feature representation by selectively focusing on the most discriminative regions while suppressing irrelevant background information, thereby improving identification performance. The framework incorporates efficient preprocessing, attention based feature refinement, and a robust classification strategy optimized using the Adam Optimizer. Experiments were conducted on benchmark face recognition datasets, including Labelled Faces in the Wild (LFW), CASIA-WebFace, and a subset of VGGFace2, under realistic conditions with variations in illumination, pose, and occlusion. The results demonstrate that the proposed model achieves a high classification accuracy of 97.8%, outperforming conventional models such as baseline CNN, ResNet, and standard MobileNet. The confusion matrix analysis indicates strong class-wise discrimination with minimal misclassification, while ROC-AUC evaluation confirms robust performance across all classes. Additionally, the proposed approach maintains low computational complexity and reduced inference time, making it suitable for real-time surveillance and edge-based applications.

Shortcut learning causes deep learning models to rely on non-essential features within the data. However, its formation in deep neural network training still lacks theoretical understanding. In this paper, we provide a formal definition of core and shortcut features and employ evolutionary game theory to analyze the origins of shortcut bias by modeling data samples as players and their corresponding neural tangent features as strategies, assuming the existence of core and shortcut subnetworks. We find that gradient descent (GD) and stochastic gradient descent (SGD) lead to two distinct stochastically stable states, each corresponding to a different strategy. The former primarily optimizes the shortcut subnetwork, while the latter primarily optimizes the core subnetwork. We investigate the influence of these strategies on shortcut bias through a continuous stochastic differential equation, and reveal the impact of data noise and optimization noise on the formation of shortcut bias. In brief, our work employs evolutionary game theory to characterize the dynamics of shortcut bias formation and provides a theoretical view on its mitigation.

Managing municipal solid waste in rapidly urbanizing Sub-Saharan Africa remains challenging due to dispersed informal dumping and limited high-resolution datasets for spatial monitoring. We present an open-access deep learning model for automated detection of openly dumped dispersed solid waste via crowdsourced UAV imagery, trained and evaluated across 29 regions in 10 countries, encompassing diverse environmental contexts. A deep learning model trained on manually annotated image tiles achieved excellent performance in detecting openly dumped dispersed solid waste across all study regions. Predicted distributions reveal heterogeneous accumulation patterns, ranging from localized hotspots - often along waterways, where waste can exacerbate flood and public health risks - to more dispersed litter across urban areas. Waste accumulation is most strongly associated with population density and indicators of lack of local infrastructure access, whereas its relationship with broader measures of regional development is weaker, highlighting the importance of fine-scale data for understanding localized waste dynamics. By releasing the model, this study provides a ready-to-use tool for UAV imagery collected by municipalities and local mapping communities, enabling openly dumped dispersed solid waste monitoring without extensive technical expertise. This approach empowers local practitioners to convert UAV imagery into actionable insights, supporting targeted interventions and improved municipal solid waste management across Sub-Saharan Africa.

Deep neural networks dominate modern machine learning, while alternative function approximators remain comparatively underexplored at scale. In this work, we revisit kernel methods as drop-in components for standard deep learning pipelines. We introduce \emph{Sparse Kernels} (SKs), a differentiable, localized, and lazy variant of kernel ridge regression (KRR) that defers training to inference time and reduces to the solution of small local systems. We integrate SKs into PyTorch as modular layers that preserve end-to-end trainability, and we show that they expose three distinct sets of parameters -- feature representations, target values, and evaluation points -- each of which can be fixed or learned. This decomposition broadens the design space available to practitioners, enabling, in particular, training-free transfer, nonlinear probing, and hybrid kernel-neural models. Across convolutional networks, vision transformers, and reinforcement learning, SK-based modules serve two complementary roles: in some settings, they match the performance of trained neural readouts with substantially less training; in others, they augment existing models and improve their performance when used as additional components. Our results suggest that kernel methods, once made scalable and differentiable, can be readily integrated with deep learning rather than treated as a separate paradigm.

In recent years, several advances have been observed in Deep Learning with surprising results. Models in this area have been increasingly used in numerous applications, including those sensitive to human life, which require clear explanations and justifications. Various explainability methods have been proposed, but not many metrics to evaluate these methods. The most commonly used metric is the Intersection over Union (IoU). However, due to the characteristics of the results of the explainability methods, called saliency maps, which do not have a known shape, we hypothesise that there must be a better metric that allows one to find an explainability method that produces results that best resemble the human perception. We propose using different metrics to assess the similarity between human perception and the explanation saliency maps to find a better metric. An investigation was conducted employing a subset of the Chihuahuas images from ImageNet dataset. Several CAM-based explainability methods were used to generate saliency maps for each chihuahua image. Alignment was measured by applying distance metrics between the bounding box of human annotations and the saliency maps produced by each explainability method. Rankings of the best saliency maps were created using the results of the distance metrics and compared to the ranking obtained using people's choice, collected through crowdsourcing, of the best explanation saliency maps for each selected image. Comparison between rankings was performed using the Rank-Biased Overlap (RBO) metric. The results indicate the feasibility of our method to find the explainability method that best resembles human perception. In our experiments, the two metrics that best resemble human perception corresponded to Manhattan and Correlation. Besides, the best explainability methods regarding human perception were LayerCAM, Score-CAM, and IS-CAM.

Classifying brain tumors using magnetic resonance imaging (MRI) is crucial for early diagnosis and treatment; however, tumor heterogeneity and a dearth of annotated datasets restrict the use of supervised deep learning approaches. In this work, we use self-supervised learning (SSL) to study multi-class brain tumor classification. Using a ResNet-50 backbone, we evaluate four SSL frameworks including SimCLR, BYOL, DINO, and Moco v3 on a publicly available dataset of 4,448 MRIs with 17 distinct tumor types. On the dataset, SimCLR achieved 99.64% accuracy, 99.64% precision, 99.64% recall, and 99.64% F1-score. The workflow includes preprocessing, fine-tuning, linear evaluation, and SSL pretraining with data augmentations. Results show that, when labels are limited, SSL-pretrained models outperform supervised baselines in terms of F1-score, recall, accuracy, and precision. Additionally, by providing visual insights into model decisions, Explainable AI techniques (Grad-CAM, Grad-CAM++, EigenCAM) enhance interpretability. These results demonstrate SSL's scalability and dependability in diagnosing brain tumors from unlabeled medical data.

Fall detection is a critical task in healthcare, particularly for elderly people. Timely fall detection and treatment can prevent severe injuries. Sensor-based activity data can be used to detect fall. However, this data are highly sensitive and raises significant privacy concerns. Existing privacy approaches apply uniform noise across all training samples, which affects the prediction performance. To address this limitation, we propose a Class-Aware Adaptive Differential Privacy (CA-ADP) framework integrated with a hybrid 3D Convolutional Neural Network and Bidirectional Long Short-Term Memory (3D CNN-BiLSTM) architecture. The CA-ADP mechanism dynamically adjusts the magnitude of noise added to gradients based on the class composition of each mini-batch. This process ensures privacy while mitigates performance degradation. We formally analyze the $(ε,δ)$-Differential Privacy guarantee and provide a privacy-utility trade-off analysis. The proposed method is evaluated on three public benchmark datasets, namely SisFall, UP-Fall, and MobiAct. The experimental results show that the proposed privacy model achieves improvements of 3.3%, 8.5%, and 7.5% over the conventional privacy-based model in terms of F-score for the SisFall, UP-Fall, and MobiAct datasets, respectively. Comparisons with prior studies show that the CA-AD based framework achieves competitive performance and provides formal privacy guarantees, which are largely overlooked in existing studies. Wilcoxon signed-rank tests confirm that the proposed mechanism consistently outperforms conventional differential privacy. Those results establish the proposed CA-ADP framework as an effective approach to privacy-preserving fall detection in real-world healthcare settings.

Deep learning has been widely adopted for WiFi CSI-based human activity recognition (HAR) due to its ability to learn spatio-temporal features in a privacy-preserving and cost-effective manner. However, DL-based models generalize poorly across environments, a challenge amplified in multi-user settings where overlapping activities cause CSI entanglement and domain shifts. Practical deployments often limit access to labeled source data due to privacy constraints, motivating source-free adaptation using only unlabeled target-domain CSI and a pre-trained source model. In this paper, we propose MU-SHOT-Fi, a source-free unsupervised domain adaptation framework for single- and multi-user Wi-Fi sensing. MU-SHOT-Fi employs permutation-invariant set prediction with Hungarian matching during source training, followed by frozen-classifier backbone adaptation in the target domain. To enable stable adaptation without labels, we introduce occupancy-weighted information maximization that prevents model collapse by focusing diversity regularization on likely-occupied slots while excluding the dominant class from marginal entropy. Additionally, we employ binary rotation prediction as spatial self-supervision that exploits CSI frequency-time structure to learn domain-invariant features. For single-user scenarios, we introduce SU-SHOT-Fi by replacing occupancy weighting with standard information maximization and incorporating contrastive predictive coding to exploit temporal consistency. Extensive experiments on the WiMANS and Widar 3.0 datasets across cross-environment, cross-frequency, cross-orientation, and combined domain shifts demonstrate that MU-SHOT-Fi effectively recovers multi-user exact-activity classification performance under large domain shifts while maintaining accurate occupancy estimation and preventing collapse toward dominant classes.

We present a non-asymptotic theory of generalization in deep learning where the empirical neural tangent kernel partitions the output space. In directions corresponding to signal, error dissipates rapidly; in the vast orthogonal dimensions corresponding to noise, the kernel's near-zero eigenvalues trap residual error in a test-invisible reservoir. Within the signal channel, minibatch SGD ensures that coherent population signal accumulates via fast linear drift, while idiosyncratic memorization is suppressed into a slow, diffusive random walk. We prove generalization survives even when the kernel evolves $\mathcal{O}(1)$ in operator norm, the full feature-learning regime. This theory naturally explains disparate phenomena in deep learning theory, such as benign overfitting, double descent, implicit bias, and grokking. Lastly, we derive an exact population-risk objective from a single training run with no validation data, for any architecture, loss, or optimizer, and prove that it measures precisely the noise in the signal channel. This objective reduces in practice to an SNR preconditioner on top of Adam, adding one state vector at no extra cost; it accelerates grokking by $5 \times$, suppresses memorization in PINNs and implicit neural representations, and improves DPO fine-tuning under noisy preferences while staying $3 \times$ closer to the reference policy.