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31 papers in the last four weeks, down 11% on the four weeks before. 0.4% of all new papers.

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Latest papers 284

May 7, 2026cs.LG

Distributional Spectral Diagnostics for Localizing Grokking Transitions

In grokking, a model first fits the training data while test accuracy remains low, and only later begins to generalize. We ask whether this transition can be localized from observed training trajectories before the test accuracy rises, and formulate grokking transition localization as a diagnostic problem with an explicit threshold/FPR/lead-time trade-off. Task-dependent observables are summarized as empirical distributions, mapped to Wasserstein/quantile coordinates, and analyzed by Hankel dynamic mode decomposition (DMD); the resulting reconstruction residual, together with spectrum and effective rank, forms the diagnostic output. On held-out modular-addition Transformer runs, the residual achieves AUROC

\approx

0.93 for grokking-vs-non-grokking discrimination at the run level; under a fixed sustained-threshold operating rule, true-positive alarms can precede onset, with lead time reported jointly with false-alarm rate and uncertainty intervals. Perturbation experiments show that, in the tested

wd=1

pool, high-residual windows exhibit about

3\times

larger short-horizon perturbation deviation than low-residual windows. In a same-data norm-window control, perturbation sensitivity aligns with the residual ordering rather than total-parameter-norm ordering, suggesting that the residual is not merely a total-norm proxy at the window level in the studied

wd=1

dynamics. Norm signals remain strong run-level regime indicators, and log-probability performs best among the observables tested under the current protocol. We position the residual as a window-level monitoring and localization signal in the studied modular-arithmetic Transformer settings, not a universal early-warning predictor or an intervention rule.

Ziyue Wang, Yufeng Ying, Takafumi Kanamori

Institute of Science Tokyo · University of Science and Technology of China

Grokking Transformer Residual Streams Dynamic Mode Decomposition Spectral Transformer Architectures Diagnosis+1

May 7, 2026cs.LG

When Does Value-Aware KV Eviction Help? A Fixed-Contract Diagnostic for Non-Monotone Cache Compression

Long-context LLM inference is bottlenecked by the memory and bandwidth cost of reading large KV caches during decoding. KV compression reduces this cost by keeping only part of the cache, but task accuracy alone does not identify why a selector succeeds or fails. A selector can fail at three steps: it may miss the evidence future decoding needs, give high scores to tokens that do not affect the output, or break related evidence when fitting scores into a small cache. We introduce a fixed-contract diagnostic that holds the selector's setup fixed and changes one decision slot at a time. For value ranking, the probe combines a block's attention mass with the estimated output change from removing it. On LongBench across three models and two budgets, the probe is positive on 72.6% of positive-margin cells and 32.4% of nonpositive-margin cells. NeedleBench M-RT at 32k and a RULER 8k check probe support closure under branched retrieval, and a 264-cell sign evaluation separates support recovery and output-value ranking from leverage effects near the boundary. The resulting order is to recover decode-side evidence, rank its output value, and preserve coupled evidence during projection.

Ruijie Zhang, Haozhe Liang, Da Chang +4

Key-Value Cache Compression Key-Value Cache Eviction Key-Value Cache Cache LLM Inference Optimization Data Compression Methods+1

May 6, 2026cs.CL

Ask Before You Diagnose: Safe-Psych, a Sequential Evaluation Benchmark for LLMs in Psychiatry

Large language models (LLMs) are increasingly used for decision support in healthcare, but clinical evidence is often incomplete or evolving. When the available information is insufficient to support a reliable answer, models should request clarification or abstain rather than provide unsupported responses. Existing medical benchmarks, however, typically assume that complete information is available upfront. We introduce Safe-Psych, a sequential benchmark for evaluating how LLMs handle evolving diagnostic uncertainty in clinical psychiatry. Safe-Psych contains over 1,000 real-world psychiatric clinical notes segmented to simulate incremental evidence disclosure, with psychiatrist-derived action labels at each stage: DIAGNOSE, CLARIFY, or ABSTAIN. We evaluate multiple state-of-the-art LLMs in full-information and sequential settings. Our findings show that capability does not ensure calibration: even strong models struggle under incomplete clinical information, with under-abstention exceeding 60% for most models and safety-aware prompting reducing premature commitment only by shifting errors toward excessive abstention. In sequential evaluation, models frequently diagnose before sufficient evidence is available and rarely seek clarification unless explicitly prompted; these premature diagnoses are less accurate than on-time diagnoses. Overall, Safe-Psych reveals a limitation across the evaluated models: recognizing when clinical evidence is incomplete and additional information is needed. We release Safe-Psych to support research on improving LLM safety in healthcare.

Oriana Presacan, Andreea Grama, Larisa Irimină +6

National University of Science and Technology Politehnica Bucharest · Psychiatric Hospital Doctor Gheorghe Preda · Oslo Metropolitan University +3

Mental Health Diagnosis Psychology

May 6, 2026cs.DC

CCL-D: A High-Precision Diagnostic System for Slow and Hang Anomalies in Large-Scale Model Training

As training scales grow, collective communication libraries (CCL) increasingly face anomalies arising from complex interactions among hardware, software, and environmental factors. These anomalies typically manifest as slow/hang communication, the most frequent and time-consuming category to diagnose. However, traditional diagnostic methods remain inaccurate and inefficient, frequently requiring hours or even days for root cause analysis. To address this, we propose CCL-D, a high-precision diagnostic system designed to detect and locate slow/hang anomalies in large-scale distributed training. CCL-D integrates a rank-level real-time probe with an intelligent decision analyzer. The probe measures cross-layer anomaly metrics using a lightweight distributed tracing framework to monitor communication traffic. The analyzer performs automated anomaly detection and root-cause location, precisely identifying the faulty GPU rank. Deployed on a 4,000-GPU cluster over one year, CCL-D achieved near-complete coverage of known slow/hang anomalies and pinpointed affected ranks within 6 minutes-substantially outperforming existing solutions.

Yida Gu, Fakang Wang, Jianhao Fu +17

University of Chinese Academy of Sciences · Ant Group · Jilin University

Fast-Slow Diagnosis

May 5, 2026cs.AI

SymptomAI: Toward a Conversational AI Agent for Everyday Symptom Assessment

Language models excel at diagnostic assessments on curated medical case-studies and vignettes, performing on par with, or better than, clinical professionals. However, existing studies focus on complex scenarios with rich context making it difficult to draw conclusions about how these systems perform for patients reporting symptoms in everyday life. We deployed SymptomAI, a set of conversational AI agents for end-to-end patient interviewing and differential diagnosis (DDx), via the Fitbit app in a study that randomized participants (N=13,917) to interact with five AI agents. This corpus captures diverse communication and a realistic distribution of illnesses from a real world population. A subset of 1,228 participants reported a clinician-provided diagnosis, and 517 of these were further evaluated by a panel of clinicians during over 250 hours of annotation. SymptomAI DDx were significantly more accurate (OR = 2.56, p < 0.001) than those from independent clinicians given the same dialogue in a blinded randomized comparison. Moreover, agentic strategies which conduct a dedicated symptom interview that elicit additional symptom information before providing a diagnosis, perform substantially better than baseline, user-guided conversations (p < 0.001). An auxiliary analysis on 1,509 conversations from a general US population panel validated that these results generalize beyond wearable device users. We used SymptomAI diagnoses as labels for all 13,917 participants to analyze over 500,000 days of wearable metrics across nearly 400 unique conditions. We identified strong associations between acute infections and physiological shifts (e.g., OR > 7 for influenza). While limited by self-reported ground truth, these results demonstrate the benefits of a dedicated and complete symptom interview compared to a user-guided symptom discussion, which is the default of most consumer LLMs.

Joseph Breda, Fadi Yousif, Beszel Hawkins +30

Google Research · Work done while at Google Research · Google DeepMind

May 5, 2026cs.AI

What Happens Inside Agent Memory? Circuit Analysis from Emergence to Diagnosis

Agent memory failures are silent: an LLM-based agent can produce a fluent response even when it fails to extract, retain, or retrieve the information needed across sessions. The write-manage-read loop describes the external pipeline of these systems but leaves open which internal computations implement each stage. We trace feature circuits across the Qwen-3 family (0.6B--14B), two memory frameworks (mem0, A-MEM), and a matched Gemma-3 replication, reporting two mechanistic findings plus one deliverable. First, under mem0, control is detectable before content. Routing circuitry is causally active at 0.6B, while content circuitry produces no detectable signal until 4B. Gemma-3 reproduces the same order at 1B and 4B. Small models therefore route memory decisions before they can reliably extract or ground the underlying facts. Second, the shared hub is recruited, not created. Write and Read converge on a late-layer hub that already exists in the base model as a context-grounding substrate, on which memory framing recruits a memory-specific functional direction. The hub and the early routing circuit carry over to A-MEM, indicating that these computations belong to the base model rather than to a particular interface. Building on this circuit structure, we develop an unsupervised stage-level diagnostic that localizes silent failures to the responsible operation at 76.2% accuracy. It outperforms a strong LLM trace judge by 3.1 points as well as a supervised hidden-state probe by 8.8 points. Together, these results establish circuit-level signatures as a practical handle for monitoring agent memory and guiding its structural design.

Xutao Mao, Jinman Zhao, Gerald Penn +1

City University of Hong Kong · University of Toronto

Circuits Emergence Diagnosis

May 4, 2026cs.CV

Learning to Segment using Summary Statistics and Weak Supervision

Medical experts often manually segment images to obtain diagnostic statistics and discard the resulting annotations. We aim to train segmentation models to alleviate this burden, but constrained to the retained summary statistics (e.g., the area of the annotated region). Empirical results suggest that statistics alone are insufficient for this task, but adding weak information in the form of a few pixels within the area of interest significantly improves performance. We use a novel loss function that combines terms for image reconstruction quality, matching to summary statistics, and overlap between the predicted foreground and the weak supervisory signal. Experiments on standard image, ultrasound (breast cancer), and Computed Tomography (CT) scan (kidney tumors) data demonstrate the utility and potential of the approach.

Omkar Kulkarni, Edward Raff, Tim Oates

University of Maryland, Baltimore County, Baltimore MD, USA · Crowdstrike, Austin TX, USA

Semi-Supervised Medical Image Segmentation Loss Function Summary Statistics Diagnosis

May 4, 2026cs.CV

Improving Imbalanced Multi-Label Chest X-Ray Diagnosis via CBAM-Enhanced CNN Backbones

Chest radiography is a widely used imaging modality for thoracic disease diagnosis, yet its conventional interpretation remains time-consuming and heavily dependent on expert knowledge. While deep learning has improved diagnostic efficiency through automated feature extraction, challenges such as class imbalance and the localization of multiple co-existing pathologies remain unsolved. In this paper, inspired by the strength of Convolutional Block Attention Module (CBAM) in feature refinement and the capability of CNN blocks in feature extraction, we propose a strategy to integrate CBAM into traditional CNN blocks to enhance performance in multi-label classification tasks. Our method achieves a mean AUC of 0.8695 on ChestXray14 dataset, outperforming several state-of-the-art baselines.Our source code is available at: https://github.com/NNNguyenDuyyy/FETC_CBAM_Enhanced_CNN.git

Duy Nguyen Huu, Duy Hoang Khuong, Ngu Huynh Cong Viet

Department of Artificial Intelligence FPT University Ho Chi Minh City, Vietnam · Department of Computing Fundamental FPT University Ho Chi Minh City, Vietnam

Chest X-Ray Medical Image Classification Digitally Reconstructed Radiographs Multi-Label Classification Medical Imaging Convolutional Block Attention Module+2

May 1, 2026cs.LG

Scale-Aware Adversarial Analysis: A Diagnostic for Generative AI in Multiscale Complex Systems

Complex physical systems, from supersonic turbulence to the macroscopic structure of the universe, are governed by continuous multiscale dynamics. While modern machine learning architectures excel at mapping the high-dimensional observables of these systems, it remains unclear whether they internalize the governing physical laws or merely interpolate discrete statistical correlations. Standard Explainable AI (XAI) architectures, particularly perturbation-based and gradient-saliency methods, rely on pixel-wise perturbations, which generate unphysical artifacts and push inputs off the valid empirical distribution. To resolve this, we introduce a diagnostic framework driven by Constrained Diffusion Decomposition (CDD), a diffusion-based multiscale data decomposition algorithm that enables physically constrained data generation and model evaluation via scale-aware modifications. Applying this framework to a Denoising Diffusion Probabilistic Model (DDPM), we execute deterministic interventions directly within the continuous, CDD-based scale space. We demonstrate that under moderate physical perturbations, the unconstrained generative model exhibits localized structural freezing and non-linear instability rather than continuous PDE-like responses. The network fails to maintain cross-scale continuity, causing the generative trajectory to diverge when pushed into unseen physical states. By synthesizing a continuum of physically coherent states, this scale-informed methodology establishes a controlled test ground to evaluate algorithmic vulnerabilities, providing the rigorous physical constraints necessary for future architectures to respect the multiscale causality of the natural universe.

Mengke Zhao, Guang-Xing Li, Duo Xu +1

School of Astronomy and Space Science, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, Jiangsu, People’s Republic of China · Key Laboratory of Modern Astronomy and Astrophysics (Nanjing University), Ministry of Education, Nanjing 210023, Jiangsu, People’s Republic of China · South-Western Institute for Astronomy Research, Yunnan University, Kunming 650091, People’s Republic of China +1

Multiscale Dynamics Generative Artificial Intelligence Multiscale Diagnosis

May 1, 2026cs.AI

From ML Predictions to Informed Diagnostic Assistance Using the Toulmin Model of Argumentation

To provide a structured and interpretable assessment, we decompose the image-based diagnosis into components following the Toulmin model of argumentation. This model consists of a claim, grounds, warrant, qualifier, rebuttal, and backing. Consider a claim generated by a machine learning (ML) model for retinal diagnosis. Rather than accepting this claim at face value, one could either apply explainable AI (XAI) methods or adopt an argumentation-based approach. In our framework, a model specialized in biomarker extraction from images provides the grounds. The warrant-linking the grounds to the claim - is analyzed by an agent equipped with medical knowledge; in our architecture, this role is fulfilled by a MedGemma agent. The qualifier is determined based on the overall quantitative evaluation of both the warrant and grounds models. Finally, a rebuttal is constructed using image similarity measures computed with MedSigLip. All these components are presented to the human expert, enabling a more informed and critical assessment of the ML-generated diagnosis.

Anca Marginean, Adrian Groza

Diagnosis Biomarker Argumentation Frameworks

Apr 30, 2026cs.SE

Hierarchical Fault Detection and Diagnosis for Transformer Architectures

Transformers now underpin critical AI systems across industry and research. Yet their faults can silently alter model behavior without runtime errors, and existing techniques offer little support for tracing these failures to their component and root cause. Such faults evade detection because loss and numerical values stay normal, and the visible symptom rarely identifies the component responsible. We present DEFault++, a hierarchical learning-based technique that first detects a fault, then identifies the affected component, and finally the cause within it, helping developers effectively debug transformer models. DEFault++ organizes component-level runtime measurements with a Fault Propagation Graph (FPG), a structural prior over the architecture's dependency paths, and reports the evidence behind each diagnosis. To train and evaluate it, we construct DEFault-bench, a benchmark of 5,556 labeled runs from mutation testing across seven models, nine tasks, and both encoder and decoder architectures. DEFault++ improves fault detection over four prior techniques, reaching an F1 of 0.826--0.909, and in a developer study with 21 participants, it raises repair accuracy from 57.1% to 83.3%. These results show that transformer fault diagnosis benefits from component-level measurements and architecture-aware reasoning rather than model-level behavior alone, and DEFault-bench provides a foundation for further research on transformer fault diagnosis.

Sigma Jahan, Saurabh Singh Rajput, Tushar Sharma +1

Dalhousie University, Halifax, Canada

Fault Diagnosis Transformer Architectures Diagnosis Interpretable Anomaly Detection

Apr 29, 2026cs.CV

Are Data Augmentation and Segmentation Always Necessary? Insights from COVID-19 X-Rays and a Methodology Thereof

Purpose: Rapid and reliable diagnostic tools are crucial for managing respiratory diseases like COVID-19, where chest X-ray analysis coupled with artificial intelligence techniques has proven invaluable. However, most existing works on X-ray images have not considered lung segmentation, raising concerns about their reliability. Additionally, some have employed disproportionate and impractical augmentation techniques, making models less generalized and prone to overfitting. This study presents a critical analysis of both issues and proposes a methodology (SDL-COVID) for more reliable classification of chest X-rays for COVID-19 detection. Methods: We use class activation mapping to obtain a visual understanding of the predictions made by Convolutional Neural Networks (CNNs), validating the necessity of lung segmentation. To analyze the effect of data augmentation, deep learning models are implemented on two levels: one for an augmented dataset and another for a non-augmented dataset. Results: Careful analysis of X-ray images and their corresponding heat maps under expert medical supervision reveals that lung segmentation is necessary for accurate COVID-19 prediction. Regarding data augmentation, test accuracy significantly drops beyond a certain threshold with additional augmented images, indicating model overfitting. Conclusion: Our proposed methodology, SDL-COVID, achieves a precision of 95.21% and a lower false negative rate, ensuring its reliability for COVID-19 detection using chest X-rays.

Aman Swaraj, Arnav Agarwal, Hitendra Singh Bhadouria +2

Department of Computer Science and Engineering, Indian Institute of Technology Roorkee, India – 247667 · United Health Group, Optum division · Department of Computer Science and Engineering, National Institute of Technology, Delhi, India – 110036

Chest X-Ray Data Augmentation Deep Learning Diagnosis Methodology Insights

Apr 29, 2026cs.CY

Algorithmic Authority and the Clinical Standard of Care

The integration of artificial intelligence into clinical medicine creates a fundamental tension between algorithmic probabilistic reasoning and the experiential intuition of expert physicians; applying Lawrence Lessig's \enquote{Code is Law} framework, I argue that the architecture of clinical AI systems already functions as de facto medical regulation, reshaping liability and the standard of care. Reframing AI \enquote{hallucination} as structurally analogous to well-documented human cognitive failures such as confirmation bias and premature diagnostic closure, I show that both failure modes demand a unified governance response. I therefore propose a dialectical standard of care that treats the integrated AI-physician dyad as the singular responsible diagnostic entity, mandating the synthesis of algorithmic precision with human interpretive authority within robust data governance and patient privacy frameworks.

Aizierjiang Aiersilan

The George Washington University

Diagnosis Algorithmic Cores

Apr 28, 2026cs.LG

Gradient-Direction Sensitivity Reveals Linear-Centroid Coupling Hidden by Optimizer Trajectories

We show that replacing the rolling SVD of AdamW updates with a rolling SVD of loss gradients changes the diagnostic by 1-2 orders of magnitude. Performing SVD on the loss gradient instead of the AdamW update increases the measured perturbative coupling between SED directions and Linear Centroid Hypothesis (LCH) features from

\bar{R}_k \approx 3

--

9\times

to

100

--

330\times

across four single-task modular arithmetic operations, eliminating the apparent operation dependence in the original measurement. On a multitask transformer with a shared encoder, update-based SED gives

\bar{R}_k \leq 1

-- an apparent failure of the diagnostic -- while per-operation gradient-based SED recovers

\bar{R}_k = 20

--

45\times

across all four operations. Gradient aggregation across competing tasks is the main obstruction; performing SVD on per-task gradients resolves it. A causal intervention shows that constraining attention updates to any rank-3 subspace (whether SED-derived or random) accelerates grokking by approximately

2.3\times

across random seeds and operations, while removing the rank-3 component has negligible effect under proper gradient-projection methodology. The SED-LCH coupling is therefore a strong diagnostic of where feature formation concentrates in parameter space, but it is not a unique causal pathway: the natural full-rank AdamW attention update is highly rank-redundant under our hyperparameters.

Yongzhong Xu

Adam Singular Value Decomposition Diagnosis Robust Trajectory Sound Event Detection

Apr 27, 2026cs.CL

MultiDx: A Multi-Source Knowledge Integration Framework towards Diagnostic Reasoning

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to limited domain knowledge. Existing approaches often rely on internal model knowledge or static knowledge bases, resulting in knowledge insufficiency and limited adaptability, which hinder their capacity to perform diagnostic reasoning. Moreover, these methods focus solely on the accuracy of final predictions, overlooking alignment with standard clinical reasoning trajectories. To this end, we propose MultiDx, a two-stage diagnostic reasoning framework that performs differential diagnosis by analyzing evidence collected from multiple knowledge sources. Specifically, it first generates suspected diagnoses and reasoning paths by leveraging knowledge from web search, SOAP-formatted case, and clinical case database. Then it integrates multi-perspective evidence through matching, voting, and differential diagnosis to generate the final prediction.~Extensive experiments on two public benchmarks demonstrate the effectiveness of our approach.

Yimin Deng, Zhenxi Lin, Yejing Wang +9

Xi’an Jiaotong University · City University of Hong Kong · Tencent Jarvis Lab +1

Clinical Reasoning Training Diagnosis Reasoning Trajectory

Apr 26, 2026cs.CV

Risk-Aware Robust Learning: Reducing Clinical Risk under Label Noise in Medical Image Classification

Noisy labels are a pervasive challenge in medical image classification, where annotation errors arise from inter-observer variability and diagnostic ambiguity. Although several noise-robust learning methods have been proposed, their evaluation predominantly relies on accuracy-oriented metrics, overlooking the clinical implications of asymmetric error costs. In medical diagnosis, a false negative (missed disease) carries substantially higher consequences than a false positive (false alarm), as delayed treatment can directly impact patient outcomes. In this work, we investigate whether noise-robust training methods preserve clinical safety under label noise. We conduct a systematic risk-aware evaluation of the state-of-the-art noise-robust methods Coteaching, DivideMix, UNICON, and a GMM-based filtering approach on binarized DermaMNIST and PathMNIST datasets under clean and label noise rates of 20%, and 40%. Beyond balanced accuracy, we adopt a cost-sensitive Global Risk formulation that explicitly penalizes false negatives. Our analysis reveals that the robustness of state-of-the-art methods does not guarantee clinical safety. Furthermore, we demonstrate that integrating cost-sensitive optimization into noise-robust training significantly reduces clinical risk, while mantaining model utility. These findings demonstrate that noise-robust learning must be evaluated through a clinical risk lens, and that combining robust training with cost-sensitive optimization can meaningfully reduce risk in noisy-label medical imaging scenarios.

Maycon R. S. Pereira, Filipe R. Cordeiro

Visual Computing Lab, Departamento de Computac¸˜ao, Universidade Federal Rural de Pernambuco (UFRPE), Brasil

Noisy Labels Medical Image Classification Noise-Aware Diagnosis

Apr 23, 2026cs.CV

Divide-then-Diagnose: Weaving Clinician-Inspired Contexts for Ultra-Long Capsule Endoscopy Videos

Capsule endoscopy (CE) enables non-invasive gastrointestinal screening, but current CE research remains largely limited to frame-level classification and detection, leaving video-level analysis underexplored. To bridge this gap, we introduce and formally define a new task, diagnosis-driven CE video summarization, which requires extracting key evidence frames that covers clinically meaningful findings and making accurate diagnoses from those evidence frames. This setting is challenging because diagnostically relevant events are extremely sparse and can be overwhelmed by tens of thousands of redundant normal frames, while individual observations are often ambiguous due to motion blur, debris, specular highlights, and rapid viewpoint changes. To facilitate research in this direction, we introduce VideoCAP, the first CE dataset with diagnosis-driven annotations derived from real clinical reports. VideoCAP comprises 240 full-length videos and provides realistic supervision for both key evidence frame extraction and diagnosis. To address this task, we further propose DiCE, a clinician-inspired framework that mirrors the standard CE reading workflow. DiCE first performs efficient candidate screening over the raw video, then uses a Context Weaver to organize candidates into coherent diagnostic contexts that preserve distinct lesion events, and an Evidence Converger to aggregate multi-frame evidence within each context into robust clip-level judgments. Experiments show that DiCE consistently outperforms state-of-the-art methods, producing concise and clinically reliable diagnostic summaries. These results highlight diagnosis-driven contextual reasoning as a promising paradigm for ultra-long CE video summarization.

Bowen Liu, Li Yang, Shanshan Song +6

1The Hong Kong University of Science and Technology · 2Renji Hospital, Shanghai Jiao Tong University School of Medicine

Colonoscopy Diagnosis

Apr 23, 2026cs.AI

GeoMind: An Agentic Workflow for Lithology Classification with Reasoned Tool Invocation

Lithology classification in well logs is a fundamental geoscience data mining task that aims to infer rock types from multi dimensional geophysical sequences. Despite recent progress, existing approaches typically formulate the problem as a static, single-step discriminative mapping. This static paradigm limits evidence-based diagnostic reasoning against geological standards, often yielding predictions that are detached from geological reality due to a lack of domain priors. In this work, we propose GeoMind, a tool-augmented agentic framework that models lithology classification as a sequential reasoning process. GeoMind organizes its toolkit into perception, reasoning, and analysis modules, which respectively translate raw logs into semantic trends, infer lithology hypotheses from multi-source evidence, and verify predictions against stratigraphic constraints. A global planner adaptively coordinates these modules based on input characteristics, enabling geologically plausible and evidence-grounded decisions. To guarantee the logical consistency of GeoMind, we introduce a fine-grained process supervision strategy. Unlike standard methods that focus solely on final outcomes, our approach optimizes intermediate reasoning steps, ensuring the validity of decision trajectories and alignment to geological constraints. Experiments on four benchmark well-log datasets demonstrate that GeoMind consistently outperforms strong baselines in classification performance while providing transparent and traceable decision-making processes.

Yitong Zhou, Mingyue Cheng, Jiahao Wang +2

State Key Laboratory of Cognitive Intelligence, University of Science and Technology of China, Hefei, China

Lithology Classification Agentic Workflows Tool Invocation Diagnosis

Apr 22, 2026cs.AI

Value-Conflict Diagnostics Reveal Widespread Alignment Faking in Language Models

Alignment faking, where a model behaves aligned with developer policy when monitored but reverts to its own preferences when unobserved, is a concerning yet poorly understood phenomenon, in part because current diagnostic tools remain limited. Prior diagnostics rely on highly toxic and clearly harmful scenarios, causing most models to refuse immediately. As a result, models never deliberate over developer policy, monitoring conditions, or the consequences of non-compliance, making these diagnostics fundamentally unable to detect alignment faking propensity. To support study of this phenomenon, we first introduce VLAF, a diagnostic framework grounded in the hypothesis that alignment faking is most likely when developer policy conflicts with a model's strongly held values. VLAF uses morally unambiguous scenarios to probe this conflict across diverse moral values, bypassing refusal behavior while preserving meaningful deliberative stakes. Using VLAF, we find that alignment faking is substantially more prevalent than previously reported, occurring in models as small as 7B parameters - with olmo2-7b-instruct faking alignment in 37% of cases. Finally, we show that oversight conditions induce activation shifts that lie along a single direction in representation space. This means the behavioral divergence driving alignment faking can be captured by a single contrastive steering vector, which we exploit for lightweight inference-time mitigation. Finally, we exploit this for mitigation that requires no labeled data and minimal computational overhead, achieving relative reductions in alignment faking of 85.8%, 94.0%, and 57.7% on olmo2-7b-instruct, olmo2-13b-instruct, and qwen3-8b respectively.

Inderjeet Nair, Jie Ruan, Lu Wang

Computer Science and Engineering University of Michigan Ann Arbor, MI 48109, USA

Fake News Inference-Time Defense Diagnostic Framework Behavioral Divergence Diagnosis

Apr 20, 2026cs.CL

Experiments or Outcomes? Probing Scientific Feasibility in Large Language Models

Scientific feasibility assessment asks whether a claim is consistent with established knowledge and whether experimental evidence could support or refute it. We frame feasibility assessment as a diagnostic reasoning task in which, given a hypothesis, a model predicts feasible or infeasible and justifies its decision. We evaluate large language models (LLMs) under controlled knowledge conditions (hypothesis-only, with experiments, with outcomes, or both) and probe robustness by progressively removing portions of the experimental and/or outcome context. Across multiple LLMs and two datasets, providing outcome evidence is generally more reliable than providing experiment descriptions. Outcomes tend to improve accuracy beyond what internal knowledge alone provides, whereas experimental text can be brittle and may degrade performance when the context is incomplete. These findings clarify when experimental evidence benefits LLM-based feasibility assessment and when it introduces fragility.

Seyedali Mohammadi, Manas Gaur, Francis Ferraro

University of Maryland, Baltimore County, MD, USA

Feasibility Hypothesis Diagnosis

Apr 20, 2026cs.LG

Multi-Level Temporal Graph Networks with Local-Global Fusion for Industrial Fault Diagnosis

Fault detection and diagnosis are critical for the optimal and safe operation of industrial processes. The correlations among sensors often display non-Euclidean structures where graph neural networks (GNNs) are widely used therein. However, for large-scale systems, local, global, and dynamic relations extensively exist among sensors, and traditional GNNs often overlook such complex and multi-level structures for various problems including the fault diagnosis. To address this issue, we propose a structure-aware multi-level temporal graph network with local-global feature fusion for industrial fault diagnosis. First, a correlation graph is dynamically constructed using Pearson correlation coefficients to capture relationships among process variables. Then, temporal features are extracted through long short-term memory (LSTM)-based encoder, whereas the spatial dependencies among sensors are learned by graph convolution layers. A multi-level pooling mechanism is used to gradually coarsen and learn meaningful graph structures, to capture higher-level patterns while keeping important fault related details. Finally, a fusion step is applied to combine both detailed local features and overall global patterns before the final prediction. Experimental evaluations on the Tennessee Eastman process (TEP) demonstrate that the proposed model achieves superior fault diagnosis performance, particularly for complex fault scenarios, outperforming various baseline methods.

Bibek Aryal, Gift Modekwe, Qiugang Lu

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA

Temporal Graph Neural Networks Fault Diagnosis Global-Local Fusion Framework Dual-Encoder Architectures Diagnosis Spurious Correlations

Apr 20, 2026cs.CY

First, Do No Harm (With LLMs): Mitigating Racial Bias via Agentic Workflows

Large language models (LLMs) are increasingly used in clinical settings, raising concerns about racial bias in both generated medical text and clinical reasoning. Existing studies have identified bias in medical LLMs, but many focus on single models and give less attention to mitigation. This study uses the EU AI Act as a governance lens to evaluate five widely used LLMs across two tasks, namely synthetic patient-case generation and differential diagnosis ranking. Using race-stratified epidemiological distributions in the United States and expert differential diagnosis lists as benchmarks, we apply structured prompt templates and a two-part evaluation design to examine implicit and explicit racial bias. All models deviated from observed racial distributions in the synthetic case generation task, with GPT-4.1 showing the smallest overall deviation. In the differential diagnosis task, DeepSeek V3 produced the strongest overall results across the reported metrics. When embedded in an agentic workflow, DeepSeek V3 showed an improvement of 0.0348 in mean p-value, 0.1166 in median p-value, and 0.0949 in mean difference relative to the standalone model, although improvement was not uniform across every metric. These findings support multi-metric bias evaluation for AI systems used in medical settings and suggest that retrieval-based agentic workflows may reduce some forms of explicit bias in benchmarked diagnostic tasks. Detailed prompt templates, experimental datasets, and code pipelines are available on our GitHub.

Sihao Xing, Zaur Gouliev

School of Enterprise Computing and Digital Transformation Technological University Dublin · School of Information and Communication Studies University College Dublin

Large Language Model Bias Diagnosis Agentic Workflows Harms

Apr 18, 2026cs.CV

Multimodal Fusion of Histopathology Images and Electronic Health Records for Early Breast Cancer Diagnosis

Breast cancer is a leading cause of cancer-related mortality worldwide, and timely accurate diagnosis is critical to improving survival outcomes. While convolutional neural networks (CNNs) have demonstrated strong performance on histopathology image classification, and machine learning models on structured electronic health records (EHR) have shown utility for clinical risk stratification, most existing work treats these modalities in isolation. This paper presents a systematic multimodal framework that integrates patch-level histopathology features from the BreCaHAD dataset with structured clinical data from MIMIC-IV. We train and evaluate unimodal image models (a simple CNN baseline and ResNet-18 with transfer learning), unimodal tabular models (XGBoost and a multilayer perceptron), and an intermediate-fusion model that concatenates latent representations from both modalities. ResNet-18 achieves near-perfect accuracy (1.000) and AUC (1.000) on three-class patch-level classification, while XGBoost achieves 98% accuracy on the EHR prediction task. The intermediate fusion model yields a macro-average AUC of 0.997, outperforming all unimodal baselines and delivering the largest improvements on the diagnostically critical but class-imbalanced mitosis category (AUC 0.994). Grad-CAM and SHAP interpretability analyses validate that model decisions align with established pathological and clinical criteria. Our results demonstrate that multimodal integration delivers meaningful improvements in both predictive performance and clinical transparency.

Aditya Shribhagwan Khandelwal, Mohammad Samar Ansari, Asra Aslam

University of Sheffield, UK · University of Chester, UK

Digital Pathology Multimodal Clinical Data Multimodal Fusion Electronic Health Records Diagnosis Convolutional Neural Networks

Apr 17, 2026eess.IV

Dual-Modal Lung Cancer AI: Interpretable Radiology and Microscopy with Clinical Risk Integration

Lung cancer remains one of the leading causes of cancer-related mortality worldwide. Conventional computed tomography (CT) imaging, while essential for detection and staging, has limitations in distinguishing benign from malignant lesions and providing interpretable diagnostic insights. To address this challenge, this study proposes a dual-modal artificial intelligence framework that integrates CT radiology with hematoxylin and eosin (H&E) histopathology for lung cancer diagnosis and subtype classification. The system employs convolutional neural networks to extract radiologic and histopathologic features and incorporates clinical metadata to improve robustness. Predictions from both modalities are fused using a weighted decision-level integration mechanism to classify adenocarcinoma, squamous cell carcinoma, large cell carcinoma, small cell lung cancer, and normal tissue. Explainable AI techniques including Grad-CAM, Grad-CAM++, Integrated Gradients, Occlusion, Saliency Maps, and SmoothGrad are applied to provide visual interpretability. Experimental results show strong performance with accuracy up to 0.87, AUROC above 0.97, and macro F1-score of 0.88. Grad-CAM++ achieved the highest faithfulness and localization accuracy, demonstrating strong correspondence with expert-annotated tumor regions. These results indicate that multimodal fusion of radiology and histopathology can improve diagnostic performance while maintaining model transparency, suggesting potential for future clinical decision support systems in precision oncology.

Baramee Sukumal, Aueaphum Aueawatthanaphisut

Hatyaiwittayalai School, Hat Yai, Songkhla, Thailand, 90110 · School of Information, Computer, and Communication Technology,2026 Sirindhorn International Institute of Technology, Thammasat University, Pathum Thani, Thailand

Cancer Detection Radiology Report Generation Cone-Beam Computed Tomography Diagnosis Microscopy

Apr 16, 2026cs.LG

Can LLMs Accurately Score Medical Diagnoses and Clinical Reasoning?

Evaluating medical AI systems using expert clinician panels is costly and slow, motivating the use of large language models (LLMs) as alternative adjudicators. Here, we evaluate an LLM Jury, composed of three frontier AI models, for scoring 3334 diagnoses on 300 real-world low- and middle-income country (LMIC) hospital cases. Both LLM- and clinician-generated diagnoses are scored against expert panel diagnoses across four dimensions: diagnosis, differential diagnosis, clinical reasoning, and negative treatment risk. The LLM Jury scores are compared with expert and independent re-scoring panel scores to assess error metrics, inter-rater agreement, severe-risk errors, and the effect of post hoc calibration using isotonic regression. In our data, we find that: (i) the uncalibrated LLM Jury scores preserve ordinal agreement with the expert clinician panel scores, but are systematically lower; (ii) the probability of severe-risk errors is lower for the LLM Jury than the human expert re-score panels; (iii) the LLM Jury combined with LLM diagnoses can be used to identify diagnoses at high risk of error, enabling targeted expert review and improved panel efficiency; (iv) the calibrated LLM Jury scores and rankings of diagnosing agents show excellent agreement with those of the primary expert panels; (v) LLM Jury models show no self-preference bias, they did not score diagnoses generated by their own underlying model or models from the same vendor more (or less) favourably than those generated by other models. Together, these results provide evidence that a calibrated LLM Jury is a trustworthy and reliable proxy for expert clinician evaluation in medical AI benchmarking. Confirming these findings in other clinical settings is an important direction for future work.

Amy Rouillard, Sitwala Mundia, Linda Camara +8

aWits MIND Institute, University of the Witwatersrand, Johannesburg, South Africa · fSchool of Computer Science and Applied Mathematics, University of the Witwatersrand, Johannesburg, South Africa · bGrai Labs, Cape Town, South Africa +3

Clinician Trust Large Language Model Judges Diagnosis

Mar 31, 2026cs.CL

Learning Diagnostic Reasoning for Decision Support in Toxicology

Acute poly-substance intoxication requires rapid, life-saving decisions under substantial uncertainty, as clinicians must rely on incomplete ingestion details and nonspecific symptoms. Effective diagnostic reasoning in this chaotic environment requires fusing unstructured, non-medical narratives (e.g. paramedic scene descriptions and unreliable patient self-reports or known histories), with structured medical data like vital signs. While Large Language Models (LLMs) show potential for processing such heterogeneous inputs, they struggle in this setting, often underperforming simple baselines that rely solely on patient histories. To address this, we present DeToxR (Decision-support for Toxicology with Reasoning), the first adaptation of Reinforcement Learning (RL) to emergency toxicology. We design a robust data-fusion engine for multi-label prediction across 14 substance classes based on an LLM finetuned with Group Relative Policy Optimization (GRPO). We optimize the model's reasoning directly using a clinical performance reward. By formulating a multi-label agreement metric as the reward signal, the model is explicitly penalized for missing co-ingested substances and hallucinating absent poisons. Our model significantly outperforms its unadapted base LLM counterpart and supervised baselines. Furthermore, in a preliminary clinical validation study, the model indicates a clinical advantage by achieving higher micro-F1 (0.644 vs 0.473) and recall in identifying the correct poisons. These results demonstrate the potential of RL-aligned LLMs to synthesize unstructured pre-clinical narratives and structured medical data for decision support in high-stakes environments.

Nico Oberländer, David Bani-Harouni, Tobias Zellner +3

Computer Aided Medical Procedures, Technical University of Munich, Germany · Munich Center for Machine Learning (MCML), Germany · Department of Clinical Toxicology and Poison Control Center Munich, TUM Klinikum rechts der Isar, Germany

LLM Reasoning Strategies Toxicity Diagnosis Clinical Notes Clinical

Mar 20, 2026eess.IV

ReconMIL: Synergizing Latent Space Reconstruction with Bi-Stream Mamba for Whole Slide Image Analysis

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with two critical issues. First, directly applying frozen, task-agnostic features often leads to suboptimal separability due to the domain gap with specific histological tasks. Second, relying solely on global aggregators can cause over-smoothing, where sparse but critical diagnostic signals are overshadowed by the dominant background context. In this paper, we present ReconMIL, a novel framework designed to bridge this domain gap and balance global-local feature aggregation. Our approach introduces a Latent Space Reconstruction module that adaptively projects generic features into a compact, task-specific manifold, improving boundary delineation. To prevent information dilution, we develop a bi-stream architecture combining a Mamba-based global stream for contextual priors and a CNN-based local stream to preserve subtle morphological anomalies. A scale-adaptive selection mechanism dynamically fuses these two streams, determining when to rely on overall architecture versus local saliency. Evaluations across multiple diagnostic and survival prediction benchmarks show that ReconMIL consistently outperforms current state-of-the-art methods, effectively localizing fine-grained diagnostic regions while suppressing background noise. Visualization results confirm the models superior ability to localize diagnostic regions by effectively balancing global structure and local granularity.

Lubin Gan, Jing Zhang, Heng Zhang +4

USTC, Anhui, China · Anhui Province Key Laboratory of Biomedical Imaging and Intelligent Processing, Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Anhui, China · SCNU, Guangdong, China +2

Whole-Slide Images Multiple Instance Learning Feature Pyramid Mamba-Based Models Diagnosis Latent Space

Mar 4, 2026cs.CL

MIND: Unified Inquiry and Diagnosis RL with Criteria Grounded Clinical Supports for Psychiatric Consultation

Psychiatric consultation requires agents to elicit discriminative evidence, map uncertain narratives to diagnostic criteria, and decide when evidence suffices. Existing dialogue and retrieval-augmented systems condition policies on raw histories or appended passages, leaving observed evidence, missing checks, differentials, and support reliability entangled. We introduce MIND, a criteria-grounded evidence-state decision interface. At each turn, MIND constructs a typed state containing observed evidence, unresolved criterion checks, active differentials, criterion-linked supports, and reliability metadata. A training-split Psychiatric Reasoning Bank supplies gated supports, turning retrieval into state construction rather than prompt injection. The same state conditions action selection, process rewards, information-gain scoring, and trajectory rectification. Under EMR-grounded simulator protocols, MIND improves accuracy by 8.8 and 7.3 points over strong inference-only, RAG, and RL baselines, with gains transferring to public MDD-5k dialogues. Matched interventions attribute these gains to the shared state rather than prompt length, retrieval text, or formatting. MIND targets screening-level decision support, not autonomous diagnosis. Code is available at https://github.com/Lingxi-mental-health/MIND.Å

Guoyi Li, Shihao Xu, Jiatong Ma +4

EverMind AI Inc., California, USA · Venus Team, Ant Group · Tianqiao and Chrissy Chen Institute, Shanghai, China +3

Mental Health Diagnosis Tool-Grounded Reasoning Discriminative Distance

Mar 1, 2026cs.AI

HVR-Met: A Hypothesis-Verification-Replanning Agentic System for Extreme Weather Diagnosis

While deep learning-based weather forecasting paradigms have made significant strides, addressing extreme weather diagnostics remains a formidable challenge. This gap exists primarily because the diagnostic process demands sophisticated multi-step logical reasoning, dynamic tool invocation, and expert-level prior judgment. Although agents possess inherent advantages in task decomposition and autonomous execution, current architectures are still hampered by critical bottlenecks: inadequate expert knowledge integration, a lack of professional-grade iterative reasoning loops, and the absence of fine-grained validation and evaluation systems for complex workflows under extreme conditions. To this end, we propose HVR-Met, a multi-agent meteorological diagnostic system characterized by the deep integration of expert knowledge. Its central innovation is the ``Hypothesis-Verification-Replanning'' closed-loop mechanism, which facilitates sophisticated iterative reasoning for anomalous meteorological signals during extreme weather events. To bridge gaps within existing evaluation frameworks, we further introduce a novel benchmark focused on atomic-level subtasks. Experimental evidence demonstrates that the system excels in complex diagnostic scenarios.

Shuo Tang, Jiadong Zhang, Gengxian Zhou +11

MAIS, Institute of Automation, Chinese Academy of Sciences · School of Artificial Intelligence, University of Chinese Academy of Sciences · Zhongguancun Academy, Beijing +3

Artificial Intelligence Weather Models Diagnosis

Feb 2, 2026cs.AI

Think Like a Doctor: Conversational Diagnosis through the Exploration of Diagnostic Knowledge Graphs

Conversational diagnosis requires multi-turn history-taking, where an agent asks clarifying questions to refine differential diagnoses under incomplete information. Existing approaches often rely on the parametric knowledge of a model or assume that patients provide rich and concrete information, which is unrealistic. To address these limitations, we propose a conversational diagnosis system that explores a diagnostic knowledge graph to reason in two steps: (i) generating diagnostic hypotheses from the dialogue context, and (ii) verifying hypotheses through clarifying questions, which are repeated until a final diagnosis is reached. Since evaluating the system requires a realistic patient simulator that responds to the system's questions, we adopt PatientSim, a persona-driven patient simulator, together with patient profiles from MIMIC-IV. We further adapt it with low-specificity symptom reporting to reflect how real-world patients describe symptoms vaguely during early clinical encounters. Experiments show improved diagnostic accuracy and efficiency over strong baselines, and physician evaluations support the realism of our simulator and the clinical utility of the generated clarifying questions. Our code will be released upon publication.

Jeongmoon Won, Seungwon Kook, Yohan Jo

Graduate School of Data Science, Seoul National University

Simulated Patients Diagnosis Patients Biomedical Knowledge Graph

Jan 19, 2026eess.IV

Pixelwise Uncertainty Quantification of Accelerated MRI Reconstruction

Parallel imaging techniques reduce magnetic resonance imaging (MRI) scan time but image quality degrades as the acceleration factor increases. In clinical practice, conservative acceleration factors are chosen because no mechanism exists to automatically assess the diagnostic quality of undersampled reconstructions. This work introduces a general framework for pixel-wise uncertainty quantification in parallel MRI reconstructions, enabling automatic identification of unreliable regions without access to any ground-truth reference image. Our method integrates conformal quantile regression with image reconstruction methods to estimate statistically rigorous pixel-wise uncertainty intervals. We trained and evaluated our model on Cartesian undersampled brain and knee data obtained from the fastMRI dataset using acceleration factors ranging from 2 to 10. An end-to-end Variational Network was used for image reconstruction. Quantitative experiments demonstrate strong agreement between predicted uncertainty maps and true reconstruction error. Using our method, the corresponding Pearson correlation coefficient was higher than 90% at acceleration levels at and above four-fold; whereas it dropped to less than 70% when the uncertainty was computed using a simpler a heuristic notion (magnitude of the residual). Qualitative examples further show the uncertainty maps based on quantile regression capture the magnitude and spatial distribution of reconstruction errors across acceleration factors, with regions of elevated uncertainty aligning with pathologies and artifacts. The proposed framework enables evaluation of reconstruction quality without access to fully-sampled ground-truth reference images. It represents a step toward adaptive MRI acquisition protocols that may be able to dynamically balance scan time and diagnostic reliability.

Ilias I. Giannakopoulos, Lokesh B Gautham Muthukumar, Yvonne W. Lui +1

Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, NYU Grossman School of Medicine, 10016, New York, NY, United States of America · Courant Institute of Mathematical Sciences, NYU, 10012, New York, NY, United States of America · Center for Advanced Imaging Innovation and Research (CAI2R), Department of Radiology, NYU Grossman School of Medicine, 10016, New York, NY, United States of America

Magnetic Resonance Imaging Reconstruction Magnetic Resonance Imaging Pixel-Level Prediction Uncertainty Acceleration Diagnosis

Nov 25, 2025cs.LG

Attention Trajectories as a Diagnostic Axis for Deep Reinforcement Learning

The emergence and evolution of feature reliance in deep reinforcement learning agents remain poorly understood. Here, we introduce a methodological framework for analyzing the learning process through quantitative analysis of saliency maps. This approach aggregates saliency information at the object and modality level into hierarchical attention profiles, quantifying how agents allocate attention over time, thereby forming attention trajectories throughout training. These profiles are then compared across controlled conditions, connected to behavioral measurements and reproduced with different saliency methods to assess the robustness of the findings. Applied to Atari 2600 benchmarks, custom Pong environments, and biomechanical user simulations in visuomotor tasks, this framework uncovers algorithm-specific attention biases, diagnosed unintended reward-driven strategies, and overfitting to redundant sensory channels. These patterns correspond to measurable behavioral differences, demonstrating empirical links between attention profiles, learning dynamics, and agent behavior. The results establish attention trajectories as a promising diagnostic axis for tracing how feature reliance develops during training and for identifying biases and vulnerabilities invisible to performance metrics alone.

Charlotte Beylier, Hannah Selder, Arthur Fleig +2

Max Planck Institute for Human Cognitive and Brain Sciences · Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI) Dresden/Leipzig · Leipzig, Germany +2

Offline Reinforcement Learning Saliency Sensory Feedback Diagnosis

Nov 4, 2025cs.RO

A Collaborative Reasoning Framework for Anomaly Diagnostics in Underwater Robotics

The safe deployment of autonomous systems in safety-critical settings requires a paradigm that combines human expertise with AI-driven analysis, especially when anomalies are unforeseen. We introduce AURA (Autonomous Resilience Agent), a collaborative framework for anomaly and fault diagnostics in robotics. AURA integrates large language models (LLMs), a high-fidelity digital twin (DT), and human-in-the-loop interaction to detect and respond to anomalous behavior in real time. The architecture uses two agents with clear roles: (i) a low-level State Anomaly Characterization Agent that monitors telemetry and converts signals into a structured natural-language problem description, and (ii) a high-level Diagnostic Reasoning Agent that conducts a knowledge-grounded dialogue with an operator to identify root causes, drawing on external sources. Human-validated diagnoses are then converted into new training examples that refine the low-level perceptual model. This feedback loop progressively distills expert knowledge into the AI, transforming it from a static tool into an adaptive partner. We describe the framework's operating principles and provide a concrete implementation, establishing a pattern for trustworthy, continually improving human-robot teams.

Markus Buchholz, Niamh Ellis, Rahaf Abu Hara +2

School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, UK

Underwater Robots Human-Robot Collaboration Diagnosis

Oct 24, 2025cs.AI

CXRAgent: Director-Orchestrated Multi-Stage Reasoning for Chest X-Ray Interpretation

Chest X-ray (CXR) plays a pivotal role in clinical diagnosis, and a variety of task-specific and foundation models have been developed for automatic CXR interpretation. However, these models often struggle to adapt to new diagnostic tasks and complex reasoning scenarios. Recently, LLM-based agent models have emerged as a promising paradigm for CXR analysis, enhancing model's capability through tool coordination, multi-step reasoning, and team collaboration, etc. However, existing agents often rely on a single diagnostic pipeline and lack mechanisms for assessing tools' reliability, limiting their adaptability and credibility. To this end, we propose CXRAgent, a director-orchestrated, multi-stage agent for CXR interpretation, where a central director coordinates the following stages: (1) Tool Invocation: The agent strategically orchestrates a set of CXR-analysis tools, with outputs normalized and verified by the Evidence-driven Validator (EDV), which grounds diagnostic outputs with visual evidence to support reliable downstream diagnosis; (2) Diagnostic Planning: Guided by task requirements and intermediate findings, the agent formulates a targeted diagnostic plan. It then assembles an expert team accordingly, defining member roles and coordinating their interactions to enable adaptive and collaborative reasoning; (3) Collaborative Decision-making: The agent integrates insights from the expert team with accumulated contextual memories, synthesizing them into an evidence-backed diagnostic conclusion. Experiments on various CXR interpretation tasks show that CXRAgent delivers strong performance, providing visual evidence and generalizes well to clinical tasks of different complexity. Code and data are valuable at this \href{https://github.com/laojiahuo2003/CXRAgent/}{link}.

Jinhui Lou, Yan Yang, Zhou Yu +4

School of Computer Science, Hangzhou Dianzi University, Hangzhou, 310018, China · Department of Automation, Tsinghua University, Beijing 100084, China · Department of Colorectal Medical Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, China +2

Chest X-Ray Clinical Reasoning Training Diagnosis Xai Expert Demonstrations

Aug 10, 2025cs.AI

EndoCogniAgent: Closed-Loop Agentic Reasoning with Self-Consistency Validation for Endoscopic Diagnosis

Endoscopic diagnosis is an iterative process in which clinicians acquire, compare, and verify local visual evidence before reaching a conclusion. Current AI systems do not adequately support this process because fine-grained evidence acquisition and multi-step reasoning remain weakly coupled, complicating reconciliation of image-derived findings with their textual interpretations. This gives rise to two failure modes, hallucinated evidence and uncorrected error accumulation, that undermine diagnostic reliability. We propose EndoCogniAgent, a closed-loop agentic framework that formulates endoscopic diagnosis as a controlled state update process for integrating complementary visual and textual evidence. At each reasoning round, a central planner selects an evidence acquisition action, specialized expert tools extract spatial and semantic observations as structured textual evidence, and a self-consistency validation mechanism examines this evidence along two dimensions, knowledge consistency against the input image and temporal consistency with prior validated findings, before updating the diagnostic state. Validated observations are admitted into the evolving state to condition subsequent planning, while insufficiently supported or conflicting findings are retained with corrective feedback that redirects the planner toward additional verification. We further introduce EndoAgentBench, a workflow-oriented benchmark comprising 6,132 question-answer pairs from 11 endoscopic datasets, to evaluate diagnostic agents across a comprehensive diagnostic chain, from fine-grained visual perception to high-level diagnostic reasoning. EndoCogniAgent achieves 85.23% overall accuracy on perception tasks and 71.13% clinical acceptance rate on reasoning tasks. Blinded clinician evaluation further shows consistent improvements in diagnostic response quality over the evaluated baselines.

Yi Tang, Kai-Ni Wang, Liang-Peng Pu +3

School of Biological Science and Medical Engineering, Southeast University, Nanjing 211189, China · Jiangsu Key Laboratory of Biomaterials and Devices, Southeast University, Nanjing 211189, China · State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing 211189, China +2

Colonoscopy Diagnosis Clinician Trust Agent Loop

Oct 19, 2024cs.CL

MultiViewDx: Evidence-Linked Multi-View Clinical Diagnosis

Medical multimodal large language models (MLLMs) can perform well on existing medical visual question answering (MedVQA) benchmarks, but their training data often does not match clinical diagnosis. Most supervision is organized around isolated images or short QA pairs, leaving two structures weakly specified: how evidence leads to a decision, and how views, series, modalities, and patient context from the same case are linked. We introduce MultiViewDx, a partly physician-validated multimodal instruction dataset for evidence-linked multi-view medical imaging diagnosis. MultiViewDx uses the clinical case as the supervision unit. It links imaging studies with patient context, normalizes heterogeneous reports into an evidence-linked workflow (evidence -> findings -> differential discussion -> diagnosis), and uses a unified image-text retriever to constrain instruction synthesis to source-supported evidence. It covers X-ray, CT, MRI, ultrasound, histopathology, and other clinical visual sources. We fine-tune MultiViewDx-8B-AN and evaluate it on both existing MedVQA benchmarks and real-world case-based diagnostic reasoning. Across four MedVQA benchmarks, it achieves the best average accuracy among compared systems (79.0%), outperforming HuatuoGPT-Vision-34B (66.7%) and Claude3-Opus (55.7%). Beyond MedVQA, on JAMA Clinical Challenge cases, it receives the strongest overall rating under a physician-designed rubric for key clinical points, diagnostic inference, and evidence grounding. Controlled ablations and clinician evaluation show that both case-level multi-view organization and evidence-linked reasoning targets contribute to the gain.

Junda Wang, Zonghai Yao, Yujan Ting +5

United Imaging Intelligence, MA, USA · Manning College of Information and Computer Sciences, University of Massachusetts Amherst, MA, USA · Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA +1

Multimodal Clinical Data Medical Visual Question Answering Diagnosis Multimodal Dataset Multi-View

Dec 23, 2023q-bio.QM

GestaltMML: Enhancing Rare Genetic Disease Diagnosis through Multimodal Machine Learning Combining Facial Images and Clinical Text

Individuals with suspected rare genetic disorders often undergo multiple clinical evaluations, imaging studies, laboratory tests, and genetic tests over a prolonged period of time, a process commonly described as the diagnostic odyssey. Addressing this odyssey has substantial clinical, psychosocial, and economic benefits. Many rare genetic diseases have distinctive facial features that artificial intelligence algorithms can use to facilitate clinical diagnosis, to prioritize candidate diseases for further laboratory or genetic testing, and to support the phenotype-driven reinterpretation of genome or exome sequencing data. Existing methods that use frontal facial photographs were built on conventional convolutional neural networks, rely exclusively on facial images, and cannot capture non-facial phenotypic traits or demographic information that are essential for accurate diagnosis. Here we introduce GestaltMML, a multimodal machine learning approach based solely on the Transformer architecture. It integrates facial images, demographic information (age, sex, ethnicity), and clinical notes (optionally a list of Human Phenotype Ontology terms) to improve prediction accuracy. We evaluate GestaltMML on 528 diseases from the GestaltMatcher Database and on several in-house and published cohorts, including Beckwith-Wiedemann syndrome, Sotos syndrome, NAA10-related neurodevelopmental syndrome, Cornelia de Lange syndrome, and KBG syndrome. GestaltMML improves on the state-of-the-art image-only ensembled model, narrows the diagnostic accuracy gap for patients from under-represented ancestries, and clarifies when multimodal fusion is beneficial and when image-only inference is preferable. The results suggest that GestaltMML can greatly narrow the candidate diagnoses of rare diseases and may facilitate the reinterpretation of sequencing data.

Da Wu, Zhanliang Wang, Hongzhuo Chen +12

Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA · Department of Mathematics, University of Pennsylvania, Philadelphia, PA 19104, USA · Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, NY 10032, USA +8

Rare Disease Multimodal Clinical Data Diagnosis Facial Images

Nov 14, 2023eess.IV

Performance of Machine Learning Classification in Sonomammogram Images using BI-RADS

This research aims to investigate the classification accuracy of various state-of-the-art image classification models across different categories of breast ultrasound images, as defined by the Breast Imaging Reporting and Data System (BI-RADS). To achieve this, we used 2,945 sonomammogram images for training and 936 images for validation, with the source cohort reported as comprising 1,540 patients. In order to conduct a thorough analysis, we employed six advanced classification architecture families, including VGG19 \cite{simonyan2014very}, ResNet50 \cite{he2016deep}, GoogleNet \cite{szegedy2015going}, ConvNeXt \cite{liu2022convnet}, EfficientNet \cite{tan2019efficientnet}, and Vision Transformers (ViT) \cite{dosovitskiy2020image}, instead of traditional machine learning models. We evaluate models in three different settings: full fine-tuning, linear evaluation and training from scratch. Our findings demonstrate the effectiveness and capability of our Computer-Aided Diagnosis (CAD) system, with a remarkable accuracy of 76.39% and an F1 score of 67.94% in the full fine-tuning setting. Our findings indicate the potential for enhanced diagnostic accuracy in the field of breast imaging, providing a solid foundation for future endeavors aiming to improve the precision and reliability of CAD systems in medical imaging.

Malitha Gunawardhana, Norbert Zolek

Auckland Bioengineering Institute University of Auckland New Zealand · Institute of Fundamental Technological Research Polish Academy of Sciences Poland

Mammography Medical Image Classification Image Classification Classifier Diagnosis

Date pendingcs.CL

Do Vision-Language Models Understand Visual Persuasiveness? A Diagnosis via Visual Persuasive Factors

Visual persuasion uses images to shape cognition, emotion, and behavior, with its effects depending on both visual attributes and semantic context. Despite recent progress, it remains unclear whether Vision-Language Models (VLMs) understand visual persuasiveness. This motivates us to ask: can VLMs assess whether an image persuasively supports an intended message, which visual factors shape this judgment, and do they align with human judgments? Through empirical analyses on image-message pairs where human raters consistently agree on the persuasiveness judgment, we show that VLMs exhibit a recall-oriented bias: they over-predict images as persuasive while achieving high recall. We introduce Visual Persuasive Factors (VPFs), a taxonomy informed by cognitive psychology for quantifying visual cues that shape persuasive judgments. Our factor-level analysis reveals that VPFs distinguish human persuasiveness judgments, whereas VLMs only partially reproduce these patterns, often generating false positives by treating persuasion-relevant cues as sufficient evidence. Building on this insight, we evaluate VPF-guided interventions and find that properly framed VPF knowledge can improve performance, but merely specifying visual cues or adding step-by-step reasoning is insufficient. By analyzing model rationales at the level of functional reasoning steps, we further identify a central bottleneck in connecting object identification to semantic message alignment.

Gyuwon Park, Hyounghun Kim

Graduate School of Artificial Intelligence, POSTECH · Department of Computer Science and Engineering, POSTECH

Persuasion Cognitive Science Diagnosis

Date pendingcs.RO

Diagnosing and Dynamically Filtering Occupancy World Models for Active Mapping

Active mapping requires a robot to select camera viewpoints that efficiently reconstruct an unknown 3D scene. To reason about unobserved regions, recent systems use pretrained occupancy networks as world models that complete missing geometry. The predicted structure contributes to expected coverage gain and constrains feasible robot motion. Consequently, occupancy errors can change both what the robot chooses to explore and where it is able to move. We diagnose these effects by holding the planner fixed and varying only the occupancy representation provided to it. We consider planning without completion, with learned occupancy, with false positives removed by a ground truth oracle, with false negatives restored by an oracle, and with ground truth occupancy. Our experiments show that correcting false positives or false negatives alone does not consistently improve final coverage. This finding reveals a gap between occupancy accuracy and downstream planning performance. Ground truth occupancy provides a much larger improvement in coverage efficiency than in endpoint coverage, suggesting that planning and reachability remain important bottlenecks even when the geometric world model is accurate. Based on these findings, we introduce a dynamic filtering strategy that preserves predictions in unexplored space while suppressing repeatedly unsupported occupancy using online observations. Preliminary examples show that this strategy can redirect viewpoint selection toward reachable surfaces that would otherwise remain unobserved.

Jiahui Zhang, Gongbo Liang, Yu Zhang

Boise State University · Texas A&M University–San Antonio

Occupancy Viewpoint-Dependent Active Perception 3D Mapping World Models Diagnosis

Date pendingcs.AI

Timely Clinical Diagnosis through Active Test Selection

There is growing interest in using machine learning (ML) to support clinical diagnosis, but most approaches rely on static, fully observed datasets and fail to reflect the sequential, resource-aware reasoning clinicians use in practice. Diagnosis remains complex and error prone, especially in high-pressure or resource-limited settings, underscoring the need for frameworks that help clinicians make timely and cost-effective decisions. We propose ACTMED (Adaptive Clinical Test selection via Model-based Experimental Design), a diagnostic framework that integrates Bayesian Experimental Design (BED) with large language models (LLMs) to better emulate real-world diagnostic reasoning. At each step, ACTMED selects the test expected to yield the greatest reduction in diagnostic uncertainty for a given patient. LLMs act as flexible simulators, generating plausible patient state distributions and supporting belief updates without requiring structured, task-specific training data. Clinicians can remain in the loop; reviewing test suggestions, interpreting intermediate outputs, and applying clinical judgment throughout. We evaluate ACTMED on real-world datasets and show it can optimize test selection to improve diagnostic accuracy, interpretability, and resource use. This represents a step toward transparent, adaptive, and clinician-aligned diagnostic systems that generalize across settings with reduced reliance on domain-specific data.

Silas Ruhrberg Estévez, Nicolás Astorga, Mihaela van der Schaar

University of Cambridge Cambridge, UK

Diagnosis Model Selection

Date pendingcs.MA

MedCollab: IBIS-Guided Multi-Agent Collaboration with Hierarchical Disease Relation Chains for Clinical Diagnosis

Clinical diagnosis is a gradual process of evidence integration, in which physicians move from symptoms and medical history to examinations, competing hypotheses, disease relations, and treatment decisions. Large language models have advanced medical text understanding and generation. Yet their clinical use remains limited by weak evidence grounding, opaque reasoning, and inconsistent links among differential diagnosis, final diagnosis, diagnostic basis, and treatment planning. We introduce MedCollab, a multi-agent framework for full-cycle clinical diagnosis and report generation. MedCollab coordinates specialist and examination agents according to patient records. It structures agent deliberation with an Issue-Based Information System (IBIS) protocol, so that each diagnostic position is supported by patient-specific evidence and medical knowledge. It also builds Hierarchical Disease Relation Chains (HDRC) to connect accepted hypotheses through progression, complication, and comorbidity relations. During multi-round deliberation, a verifier-guided consensus module evaluates evidence support, medical plausibility, and logical conflicts. It then adjusts agent contributions and filters unsupported reasoning. Experiments on ClinicalBench and MIMIC-IV show that MedCollab outperforms leading LLMs and medical multi-agent baselines in diagnostic accuracy, evidence consistency, and clinical reasoning quality. These results indicate that structured and auditable collaboration can produce more faithful and clinically coherent diagnostic reports.

Yuqi Zhan, Xinyue Wu, Tianyu Lin +6

Hangzhou Dianzi University · Zhejiang University · Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents’ Health and Diseases

Clinical Reasoning Training Diagnosis Collaboration Disease

Date pendingcs.CL

NSIDDx: A Design Framework for Neuro-Symbolic, Practitioner-First Differential Diagnosis in Low-Resource Settings

LLM-based diagnostic systems achieve high semantic accuracy on benchmarks, but open-ended evaluation on clinically uncommon presentations reveals a systematic gap between headline accuracy and verifiable clinical reliability. We evaluate an LLM+rare-disease-RAG pipeline across two cohorts and show that the paradigm produces confident outputs that are frequently unverifiable and systematically resistant to clinician interrogation. We present NSIDDx (Neuro-Symbolic Integrated Differential Diagnosis System), a design framework arguing that DDx systems in low-resource settings must treat the clinician as an active reasoning agent. We instantiate this through a neuro-symbolic pipeline with ternary symptom encoding, contradiction detection, audit strings, and practitioner override - running offline on consumer hardware. We distill five design principles for clinician-in-the-loop clinical NLP and invite the prospective studies needed to validate the claim at scale.

Aarav Singh

IIIT Naya Raipur

Diagnosis Neuro-Symbolic Framework Natural Language Processing

Date pendingcs.RO

EBench: Elemental Diagnosis of Generalist Mobile Manipulation Policies

We present EBench, a simulation benchmark that diagnoses generalist mobile manipulation policies beyond a single success-rate scalar. EBench comprises 26 diverse and challenging manipulation tasks annotated along 5 capability dimensions and 4 generalization dimensions. We evaluate state-of-the-art generalist manipulation models including

\pi_0

,

\pi_{0.5}

, XVLA, and InternVLA-A1, and reveal that the models exhibit strikingly different capability profiles:

\pi_{0.5}

achieves the highest test success rate, the best train--test retention, and the strongest mobile manipulation performance;

\pi_0

leads on dexterous fixed-base and high-precision tasks; XVLA and InternVLA-A1 exhibit complementary strengths across atomic skills and operating regimes. Beyond capability profiling, EBench analyzes the generalization ability from 4 representative perspectives, identifying the impact of different distribution shift factors. The results reveal strengths and weaknesses of models behind an overall score. We hope this benchmark offers a broad set of diagnostic signals to guide iteration on generalist manipulation models.

Ning Gao, Jinliang Zheng, Xing Gao +22

Shanghai AI Laboratory · Xi’an Jiaotong University · Institute for AI Industry Research (AIR), Tsinghua University +5