Diagnosis

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31 papers in the last four weeks, down 11% on the four weeks before. 0.4% of all new papers.

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Latest papers 284

Oct 1, 2026cs.SD

Multi-Party Backchannel Prediction: a Diagnosis, a Benchmark, and a Ceiling

Backchannel prediction has been studied almost entirely in dyadic conversation. We introduce a multi-party benchmark based on the AMI corpus, comprising 682 masked-listener views from 171 meetings, 190 speakers, and 18,697 backchannel events, with a person-disjoint held-out split. A state-of-the-art dyadic model applied zero-shot to meeting audio performs at chance (AUROC 0.499); nevertheless, its frozen acoustic features remain informative: a linear probe reaches 0.704, and retraining the predictor raises performance to 0.751. Retraining reveals a second limitation. Listener conditioning improves prediction for listeners seen during training but not for unseen listeners, and the gap remains under capacity reduction, listener-adversarial training, per-listener adaptation, and oracle lexical conditioning. Adversarial training removes only part of the speaker-identity information, while stronger removal hurts prediction, suggesting that identity is entangled with cues that are useful for backchanneling. A within-model control helps explain this pattern: with the same features and data splits, turn-onset prediction transfers to unseen listeners, while backchannel prediction does not. Backchannel rates also vary about twice as much across individuals as turn-onset rates. Since backchannels occupy only about 1% of frames, frame-level F1 is strongly affected by the base rate. We therefore report AUROC alongside event-F1 on listener-active regions. We release the benchmark and evaluation tools at https://github.com/HafsatiMohammed/bc_multiparty_release.

Mohammed Hafsati, Ahmed Loughzali

Enchanted Tools · Enchanted Tools IMT Nord Europe

Speaker Channel Adversarial Training Diagnosis

Oct 1, 2026cs.AI

SCOPE-AD: Sequential cost-aware ordinal-belief planning with energy-based models for diagnostic agents

Alzheimer's disease (AD) diagnosis requires sequential evidence acquisition under heterogeneous test costs and patient burden. Fixed-modality predictors do not jointly decide which test to acquire or when the available evidence is sufficient for diagnosis. We propose SCOPE-AD (Sequential Cost-Aware Ordinal-Belief Planning with Energy-Based Models for Diagnostic Agents) for cost-aware classification of cognitively normal (CN), mild cognitive impairment (MCI), and AD cases. A mask-aware ordinal model represents uncertainty along the ordered CN--MCI--AD continuum. Retrospective training records provide sampled Bellman targets for an energy-based teacher, whose action distributions are distilled into a Qwen policy. At deployment, the agent selects acquisition or diagnosis actions under availability and budget constraints without access to unacquired values. After each acquisition, the evidence and ordinal belief are updated before the next decision. On ADNI, SCOPE-AD achieves 77.70% Macro-F1 at an average acquisition cost of $50.46, exceeding the strongest evaluated baseline by 9.34 percentage points. Full-modality evaluation raises Macro-F1 by only 1.89 points while increasing acquisition cost by 116.7 times. These results support selective acquisition for cost-effective diagnosis.

Ziwen Yu, Ivan Koychev, Elizabeth Coulthard +7

University of Bristol, Bristol, UK · Imperial College London, London, UK · Hunan Normal University, Changsha, China +1

Mild Cognitive Impairment Diagnosis Selective Planning

Oct 1, 2026cs.CL

My FAULT: Self-Diagnosis as Credit Assignment in Self-Evolving Agentic Reinforcement Learning

Agentic reinforcement learning (RL) has emerged as a powerful approach for training large language model agents on multi-step tasks, yet reliance on terminal outcome rewards creates two credit-assignment problems, particularly in long-horizon tasks. First, same-outcome rollout groups provide no learning signal from terminal rewards. Second, terminal rewards provide only trajectory-wide feedback, making it difficult to identify which decisions caused a failure. Recent work supplements terminal rewards with finer-grained information from trajectory analysis, such as natural-language reflections on intermediate decisions and errors. However, natural-language diagnoses are difficult to use directly for credit assignment: their error claims may be unreliable, and they do not quantify how much each error should affect learning. We propose Self-Diagnosis-guided Terminal Credit Redistribution (FAULT), which turns diagnosed errors into explicit step-level credit anchored by terminal outcomes. FAULT checks diagnostic evidence and learns relative error costs from task outcomes. During training, the policy and self-diagnoser co-evolve, while error costs are updated online from recent outcomes. On ALFWorld, FAULT recovers learning signals from same-outcome groups, reaching 95% signal coverage versus 41% for GRPO and 72% for GiGPO, while better localizing credit to specific error steps. Across two model scales, FAULT delivers strong. improvements on the long-horizon ALFWorld and WebShop tasks while remaining competitive on short-horizon Search-based QA.

Yihua Zhu, Qianying Liu, Weixu Qiao +10

Alibaba Group · Kyoto University · NII LLMC +6

Credit Assignment Agentic Reinforcement Learning Step-Level Credit On-Policy Self-Evolution Diagnosis

Sep 30, 2026cs.AI

Agent Error Dataset: Scaling 50,000 Error--Diagnosis Pairs for Failure Analysis and Error-Aware Post-Training

An unsuccessful LLM agent rollout contains more information than its final reward: the observations available to the agent, the actions it chose, and the environment's responses. Reusing this experience for learning requires identifying a decision to revise and testing a concrete alternative. We introduce the Agent Error Dataset (AED), comprising 50,228 error-diagnosis pairs from 9,961 source tasks across 33 environments, 19 harness families, and 23 policy models in text-based agent systems. We retain source traces and execution metadata to support cross-setting failure analysis and re-diagnosis without repeating the original rollout. Our five-stage Agentic Error-to-Training (AET) pipeline collects natural failures, generates diagnoses and proposed corrections, and checks them against recorded evidence. Where replay is supported, we compare corrections with original-action retries from the same checkpoint under matched execution settings. We then construct separate training views for diagnosis and actor recovery. Across 3,062 matched replay pairs, first-proposal corrections raise verifier pass rates from 18.4% to 51.1%, a gain of 32.7 percentage points. Using a separately frozen diagnosis release, full-diagnosis fine-tuning on 1,656 source tasks raises Qwen3-8B's exact-step agreement with internal teacher labels from 47.2% to 63.6%, averaged over three seeds on a 943-case holdout. The strongest prompted reference in this comparison scores 54.7%, and mean agreement improves at each of four increasing training-set sizes. In a single-seed comparison of actor-training recipes, action-only repair training scores 6.67 percentage points higher on WebShop-lite than success-only training.

Kunlun Zhu, Xuyan Ye, Yibo Li +3

Apodex

Agentic Learning Large Language Model Agents Retrying Diagnosis

Sep 30, 2026cs.MA

Where Do Multi-Agent Systems Fail? Evidence-Grounded Diagnosis of Collective Mechanisms

When a multi-agent system answers correctly, it is tempting to conclude that its agents shared, checked, and used information as intended. Yet a system can break one of its collective mechanisms, the rules that govern how agents route, admit, store, and act on shared information, and still return the right answer, while a wrong answer rarely reveals which mechanism failed. We ask what evidence from an execution is sufficient to conclude that a particular mechanism was violated. Our answer is a diagnostic contract, which separates what counts as a violation from which execution records can establish one, and concludes that a violation is supported, ruled out, or unknown; removing records can make this conclusion unknown but never reverse it. We test contracts for four mechanisms by replaying executions from the step where a mechanism acts, once unchanged, once with the mechanism broken, and once with it restored. Broken mechanisms often left the answer correct. An LLM diagnoser detected many more violations from internal records than from public outputs, yet with identical records a generic prompt often claimed certainty the records did not support, which prompts stating the contracts largely avoided. The contracts also applied, in narrow form, to mechanisms in independently developed systems, but a diagnostic behavior that was nearly perfect on our benchmark degraded on an independently developed workflow. A correct outcome is therefore no substitute for records of how collective mechanisms operated, and agreement on one benchmark does not show that a diagnoser transfers to another system.

Zhengye Han

New York University New York, NY, USA

Diagnosis Collective Behaviors Violation Break

Sep 29, 2026cs.LG

Does Text Steer Neural PDE Surrogates? A Controlled Diagnostic with OperatorCLIP

Lower error from a text-conditioned neural surrogate does not, by itself, show that the model uses the meaning of the text. We examine this attribution problem with OperatorCLIP, comparing an unconditioned FNO, a constant-sentence FiLM control, and a fixed task description trained with contrastive alignment. Three-seed experiments cover Darcy2D, ShallowWater2D, and three-dimensional compressible Navier-Stokes (CNS3D). Constant conditioning has lower mean test error on both 2D tasks. Relative to this control, task text plus alignment has a similar mean on ShallowWater2D and CNS3D and a higher mean on Darcy2D; these descriptive comparisons have substantial seed uncertainty. The latter comparison changes both prompt content and loss, so it isolates neither effect. The text encoder is trained from scratch, and each conditioned model sees only one description during training. In this regime, pairwise InfoNCE cannot identify matched pairs and has minimum

\log B

. Prompt interventions show no reliable semantic ordering. This methodological caution demonstrates why pathway controls are needed; it neither establishes semantic competence of the encoder nor tests the effectiveness of text under varying physical context.

Aadi Dash, Lennon J. Shikhman, Michael Galarnyk

College of Computing, Georgia Institute of Technology · Department of Mathematics and Systems Engineering, Florida Institute of Technology · Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology

Neural Operators Text-Conditioned Diffusion Model Fourier Neural Operators Text Analysis and Detection Diagnosis

Sep 29, 2026cs.CL

KlinikeBench: Evaluating Language Models Beyond Diagnostic Accuracy

Most clinical benchmarks evaluate language models (LMs) on diagnosis using complete case descriptions. In clinical practice, however, patients present information in different ways, and clinicians must obtain relevant history and determine which examinations are needed before reaching a diagnosis. Diagnostic accuracy alone therefore cannot establish whether an agent gathered essential information or conducted an appropriate clinical assessment. Furthermore, existing benchmarks lack professional clinicians' verification. To address this gap, we introduce KlinikeBench, a benchmark of 333 clinician-authored tasks, each providing an isolated sandbox environment with a virtual patient, clinical tools, and task-specific success criteria. More than 35 clinicians contributed to case authoring and benchmark evaluation. In an empirical study, clinicians gave simulated dialogues higher mean quality ratings than reference conversations, which is adapted from real conversation. In each task, an LM has a fixed budget of turns to communicate with the patient, ask about relevant history, request examinations, follow action constraints, and record a final diagnosis. We score these steps separately as well as together. Across 31 models and seven model families, the best-performing models (e.g., GPT-6-astra and Claude Opus 5) succeed on less than 30% of tasks, even though their diagnosis accuracy reaches 90.7%. Some models benefit from talking with the patient; others diagnose well from a complete chart but perform much worse in conversation. Overall, KlinikeBench provides a testbed for evaluating the full clinical encounter and reveals a substantial gap between diagnostic accuracy and performance in interactive clinical assessment.

Xueting Fang, Zehui Li, Yang Yang +5

Zhejiang University · Imperial College London · Nanchang University +2

Clinician Trust Diagnostic Benchmark Diagnosis

Sep 29, 2026cs.AI

Diagnosing and Improving Probabilistic Reasoning in Large Language Models

Large language models (LLMs) are increasingly proposed as decision assistants who must reason probabilistically from available evidence under explicit decision costs. We propose a decision-theoretic framework that decomposes LLMs' decision loss into two components: forming accurate beliefs from provided evidence and translating those beliefs into actions that optimize a provided utility function. Using a synthetic benchmark with known ground truth, we apply the decomposition to characterize probabilistic reasoning in frontier and open-sourced models. We further evaluate whether RL interventions targeting beliefs, decisions, or both improve these components across three domains, whether improvements transfer across components and elicitation formats, and whether decision performance can improve without improvement in belief formation. We find that targeting one component of probabilistic reasoning redistributes decision loss, improving the target without necessarily transferring to others, and that jointly targeting belief formation and decision-making improves both but hinges on matched formats between training and evaluation.

Huaman Sun, Dingcheng Wang, Jason Hartline +1

Department of Computer Science Northwestern University Evanston, IL 60201, USA

LLM Reasoning Strategies Probabilistic Model Elicitation Diagnosis

Sep 29, 2026cs.AI

Active Budget Can Kill Sensitivity: Diagnosing and Repairing TopK Sparse Autoencoder Reliability

Sparse autoencoders (SAEs) are increasingly scaled to wider dictionaries to recover fine-grained structure from large language model activations. However, a feature is useful for interpretation only if it remains a stable unit of analysis when the same meaning is expressed in different surface forms. We study this reliability question for TopK SAEs via feature sensitivity. Experiments demonstrate that scaling selectively reduces the sensitivity of rare features, while common features remain comparatively stable. A controlled width

\times k

factorial experiment identifies the active budget k as the root cause: the degradation arises from the selection boundary rather than dictionary width alone. We attribute this failure to the geometry of TopK selection. The active margin, the distance to the cutoff, predicts feature loss without thresholds. Guided by this margin diagnosis, we introduce pairwise rank stabilization. Our method targets ordering failures at the cutoff and improves rare-feature sensitivity by

8.83

percentage points, while keeping reconstruction and alive-feature coverage near the baseline. Overall, our results suggest that wide TopK SAEs should be evaluated not only by reconstruction, sparsity, and feature count, but also by feature reliability under semantic variation and boundary geometry for stable interpretability.

Zhenting Huang, Bo Jiang, Junnan Liu +2

Beihang University · Monash University · Zhongguancun Laboratory

Improving Sparse Autoencoders Top-K Sparse Supervision Interpretability Token Budget Allocation Diagnosis

Sep 29, 2026cs.AI

MLToolBench: Learning Tool-Augmented Agents for Machine Learning Development

Machine learning engineering (MLE) agents have made substantial progress, but learning through ML experimentation remains costly in time and computation. Synthetic environments reduce these costs while introducing variations in data and experimental settings that require task-specific diagnosis. Access to diagnostic tools alone does not ensure that agents learn when to use them or how to act on their findings. We introduce ToolMLBench, a suite of executable tools for data inspection, code verification, and experiment diagnosis, together with an SFT and RL pipeline for learning their use. Diagnostic calls acquire evidence whose value depends on subsequent decisions, so final outcomes provide limited guidance on which calls to reinforce. We address this challenge with SPICE, which measures how privileged context changes the likelihood of a sampled tool action and uses this difference as a turn-level reward alongside the final outcome. We train on 80 synthetic tasks and evaluate on 25 in-domain and 10 out-of-domain tasks. Providing tool interfaces and descriptions alone yields inconsistent gains across unadapted models. With the same diagnostic interface, our training pipeline raises in-domain success from 24.8% to 52.4% for Qwen3-8B and from 35.6% to 69.2% for Qwen3.5-35B-A3B. The latter also improves from 31% to 48% out-of-domain, supporting learned diagnostic tool use on held-out sources and targets.

Xin Yu, Lizhu Zhang, Jiamu Bai +7

Synthetic Task Diagnosis In-Domain Accuracy

Sep 28, 2026cs.CL

Can LLMs Value the Right Evidence? Evidence-Value Misalignment in Dynamic Medical Diagnosis

A correct diagnosis reached from insufficient or misleading evidence can pose a clinical hazard, yet outcome-based accuracy may reward such lucky guesses. We call this mismatch between diagnostic decisions and the value of available evidence Evidence-Value Misalignment (EVM). To disentangle evidential grounding independently from diagnostic accuracy, we introduce MedEVM, a dynamic benchmarking environment comprising 1,050 cases across 24 disease systems. Observations arrive turn by turn, requiring models to continuously calibrate its decision by deciding whether to wait for more evidence or submit a diagnosis. Across 9 LLMs, four interesting patterns are observed. (1) Miscalibrated evidence tracking. Making a diagnosis often fails to calibrate evidence sufficiency, even in more capable models, and even worsens in reasoning mode. (2) Misaligned diagnosis submission. Confidence in the correct diagnosis often fails to ensure timely submission despite sufficient evidence. (3) Evidence order matters. Reordering the same evidence changes diagnoses even when model confidence remains similar. (4) Misleading evidence remains influential. Added misleading evidence redirects diagnoses even after prior evidence becomes sufficient. We further verify that EVM predicts errors and that preventing premature submission improves accuracy. These findings motivate Evidence-Verified Diagnosis Harness (EVD-Harness). It decouples diagnosis generation from submission through an offline Contrastive Diagnostic Wiki and three online control stages, namely observation management, proposal and witness verification, and diagnosis submission control. Across five LLMs, EVD-Harness improves accuracy by 12.0--51.1 percentage points while mitigating EVM-related failures. Our results demonstrate that verifying evidential support before submission can make diagnostic decisions more reliable.

Kehua Feng, Yunsheng Lu, Yitong Qiao +5

Zhejiang University · Ant Healthcare, Ant Group

Diagnosis Evidence Conflict

Sep 28, 2026cs.AI

RareDx: Controlled Knowledge Integration and Graph-Grounded Policy Optimization for Rare-Disease Diagnosis

Rare-disease diagnosis is a long-tail reasoning problem: phenotypes are incomplete, individual disorders are sparsely documented, and relevant evidence is distributed across ontologies, gene annotations, and biomedical text. Language models consequently favor common conditions, miss rare candidates, or produce plausible but invalid names. We introduce RareDx, which couples controlled evidence use with knowledge-graph-grounded policy optimization. RareDx-Harness normalizes heterogeneous records into one ranked-diagnosis task and compares direct inference, static retrieval, adaptive tools, and structured phenotype-gene-disease reasoning over a shared knowledge layer. The training pipeline combines Top-10 post-training with RareDx-KGPO, our knowledge-graph-grounded policy optimization method. Its reward projects predictions into a canonical disease graph and integrates curated graded relevance, ontology proximity, biomedical similarity, and phenotype consistency. Vocabulary and output-budget constraints prevent dense partial credit from rewarding fabricated or overlong differentials. Across eight benchmarks, the complete RareDx system centered on Qwen3.5-9B reaches 38.34 macro Hit@10, 1.60 points above GPT-5.5 under the archived protocol; a disjoint validation-selection audit retains a 6.80-point routing gain over Direct on held-out cases. The 27B system reaches 23.53/36.56/40.76 at Hit@1/5/10. Controlled ablations show that retrieval is not uniformly helpful and that controlled routing is central to the gain. These results indicate that structured medical knowledge can turn a compact model into a competitive diagnostic ranker across heterogeneous long-tail settings in clinical practice.

Bo Zhang, Yuchen Wang, Dongbai Li +6

Xi’an Jiaotong University · UIUC · Tsinghua University +4

Rare Disease Biomedical Knowledge Graph Diagnosis Phenotypes

Sep 28, 2026cs.LG

Physics-Guided Conditional Diffusion Model for Rare Event Synthesis and Diagnosis for the Water-Gas Shift Reaction

As the world moves towards sustainable energy sources, hydrogen (H2) can be treated as an eco-friendly alternative to fossil fuels due to its high energy density and zero carbon emissions. The water-gas shift (WGS) reaction is a widely used industrial process for hydrogen production by converting carbon monoxide and steam into hydrogen and carbon dioxide. However, occurrences like severe fouling, catalyst deterioration, and thermal runaway can hamper the reaction kinetics/process safety and decrease the yield of H2. These incidents are rare, and gathering process data under such abnormal conditions is challenging. In this work, we propose a physics-guided conditional diffusion model to generate realistic rare-event trajectories for the WGS reaction. The proposed model integrates a conditional denoising diffusion probabilistic model (CDDPM) with governing laws of the reaction to generate physically consistent process trajectories. The conditioning features allow the model to produce high-quality synthetic profiles for rare-event domains that are typically beyond the training regimes. The generated rare-event trajectories then augment the raw dataset for a balanced distribution between normal and abnormal conditions. We further propose a hazard score to assess the risk severity of the operating condition based on the operating trajectory. Deep learning models are trained with the augmented dataset to diagnose the health status of the reaction. Simulation results show that the proposed physics-guided diffusion model outperforms data-driven models in terms of the quality of synthetic data and diagnosis performance for rare events.

Md Abrar Rafid Siddique, Bibek Aryal, Qiugang Lu

Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA

Hydrogen System Components Physics-Guided Diffusion Rare Events Diagnosis

Sep 28, 2026cs.CL

Evaluating Bounded Autonomy in Regulated Agentic AI: A Diagnostic Harness with Constitutional Rewards, Escalation Labels, and Runtime Governance

We propose RegLLM, a diagnostic harness for bounded autonomy in regulated agentic workflows. It instruments six trustworthiness signals: citation validity, source grounding, schema compliance, escalation correctness, constitutional alignment, and unsafe-action rate. Signals are distinguished by their source of supervision: programmatic verifiers, task-level escalation labels, or AI-judge scores. A deterministic runtime supervisor blocks ungrounded answers and forces escalation, logging interventions. The same domain constitution informs evaluation, training rewards, and serving guardrails. Task-level should-escalate labels make the act-versus-defer decision a measurable training signal. We demonstrate the harness at smoke scale. An offline reference run (n=12) lifts escalation recall from 0 to 0.67 and reduces unsafe-action rate from 0.33 to 0.08 when governance is enabled. Two single-GPU Qwen2.5-3B LoRA/DPO pilots (n=8, same seed and evaluation split) expose substantial variation: nominally identical RL-base configurations yield task success of 0.25 versus 0.12 and escalation recall of 1.0 versus 0.5. An answer-quality adapter changes recall from 1.0 to 0.5 in Run A, but from 0.5 to 1.0 in Run B. An escalation-aware variant produces no measurable change in Run B. These small pilots do not establish reliable adapter effects or production readiness. Their contribution is diagnostic: configuration variance can overwhelm apparent tuning effects on bounded-autonomy metrics, motivating larger evaluation sets and repeated runs.

Dipankar Sarkar

Skelf Research

Escalation AI Trustworthiness Diagnosis

Sep 27, 2026cs.AI

Jev in Medicine: A Benchmark Evaluation

Jev is a non-generative "System One" model that assigns probabilities to predefined answer options and cannot answer outside them. Its accuracy and calibration on medical question-answering and case-based diagnostic-reasoning tasks are unknown. We evaluated Jev 1.13 on four medical benchmarks: MetaMedQA, PubMedQA, DiagnosisArena-MCQ and the NEJM Case Challenges. GPT-6 Sol, with (medium) and without reasoning, was the reference. The primary outcome was top-1 accuracy; key secondary outcomes were calibration, selective prediction and recognition of unanswerable questions. All 8,469 requests returned a valid answer. Jev's accuracy was similar to that of GPT-6 Sol with medium reasoning on PubMedQA (78.4% vs 78.2%;), lower on MetaMedQA (74.8% vs 82.7%) and much lower on DiagnosisArena-MCQ (59.8% vs 82.4%;) and the NEJM cases (61.8% vs 82.4%). On MetaMedQA, Jev's probabilities were the best calibrated (expected calibration error 0.063 vs 0.146), and its answers with a probability of at least 0.9 (52.9% of questions) were 93.4% accurate, but GPT-6 Sol was as accurate when it accepted a similar proportion of questions. On DiagnosisArena-MCQ, Jev's probabilities discriminated poorly (AUROC 0.645 vs 0.768). Of the 162 questions whose correct answer was "I don't know or cannot answer", Jev chose that option for 10.5% (GPT-6 Sol, 8.6%). Median latency was 0.27-0.31 s; all 2,823 items cost USD 0.08. Jev was fast and inexpensive, and its accuracy was similar to that of a frontier LLM on research abstracts but lower on examination questions and much lower on complex diagnostic cases. Task-specific validation is required before clinical use.

Alfredo Madrid-García, Beatriz Merino-Barbancho

Independent researcher Madrid, Spain

Diagnosis Preliminary Study Meta

Sep 27, 2026physics.plasm-ph

A packet-level digital hardware twin for commissioning megahertz diagnostic edge AI and plasma control system integration in tokamaks

High-bandwidth plasma diagnostics increasingly provide inputs to machine learning and signal-processing algorithms intended for real-time tokamak control, but the complete path from diagnostic sampling to control-system handoff is difficult to commission because of their sampling rates. We develop a packet-level digital hardware twin for the megahertz diagnostic edge-AI architecture. The simulator represents a 64-channel, 1 MHz beam emission spectroscopy (BES) diagnostic embedded in a 96-channel dual-carrier acquisition system, two 48-channel streams with SPAD0 sample counters, 10 GbE Hardware UDP transport, packet loss and network jitter, FPGA parsing and dual-carrier alignment, causal preprocessing and edge inference, a compact Ethernet result packet, receiver-side shared state, and a 1 kHz PCS-like control cycle. Binary UDP payloads and PCAP files are generated rather than emulating transport only at the array level. With a baseline of 20 samples per packet, each carrier generates 50,000 packets s

^{-1}

and 100 MB s

^{-1}

of user payload. A 110 ms reference run produces 11,000 HUDP packets; an intentionally dropped 20-sample packet is detected by the sample-counter continuity logic and invalidates the two overlapping 128-sample inference windows without silent interpolation. For valid windows, the configured engineering latency model gives a median last-input-to-shared-memory latency of 91.6 us and a 99th percentile of 108.1 us. A separate operating-system loopback test sends binary FPGA-result datagrams through a UDP receiver into POSIX shared memory and preserves packet sequence and CRC for 20/20 packets. Interactive GUI interfaces expose timing, packetization, network faults, inference thresholds, and control-state inspection. The framework provides a reproducible environment for testing diagnostic-to-accelerator interfaces and fail-safe behavior for deployment on fusion devices.

Semin Joung, Abhilasha Dave, Luca Scomparin +6

Department of Nuclear Engineering and Engineering Physics, University of Wisconsin–Madison, Madison, WI, USA · SLAC National Accelerator Laboratory, Menlo Park, CA, USA

Cognitive Digital Twins Field-Programmable Gate Arrays Diagnosis

Sep 27, 2026cs.AI

Is your uncertainty map wrong, or is its target? Exact diagnostics for the Tweedie diagonal, and a gradient-free alternative

A diffusion model can predict a follow-up medical scan from a baseline, but a clinician needs a per-voxel map of where that prediction can be trusted. Many such maps approximate the diagonal of the Tweedie posterior covariance, and are evaluated against another approximation of it, so whether the estimator or the target limits them is unclear. We compute the exact diagonal on six checkpoints across fourteen model-corpus conditions. Hutchinson at M=200 tracks it at rank agreement of at least 0.92 everywhere, yet in four of the fourteen the exact diagonal is anti-correlated with the denoising error, reaching -0.13, so a faithful estimator reproduces that reversal. All four are real-image conditions; on the models' own samples the reversal does not appear, so evaluating on generated samples flatters this family. What limits these maps is the target, not the estimator. We then introduce Tweedie Probe-Tangent (T-PT), a gradient-free residual probe that corrupts one model-supported prediction repeatedly and measures the voxel-wise variance of the denoiser's response. T-PT reads a different functional of the same Jacobian, and its exact second-order form ranks with the diagonal wherever the diagonal reverses; at thirty probes it returns a map too unstable to reproduce that ranking, while Hutchinson at M=5 already reproduces it, so T-PT there is not evidence against the reversal. We offer it as an instrument, not a better approximation. On brain MRI at full resolution, where every Jacobian-based estimator we test runs out of memory, T-PT leads a twenty-chain Monte-Carlo ensemble on five of eight endpoints inside tissue and trails it on none, at 16x fewer network evaluations; over the whole volume the ensemble leads, and fifty chains close the tissue gap. On lung CT the ensemble is ahead throughout. Both lose most of their discrimination where the change is, which remains open.

Vicent Ribas, Anna Oliveras Tous

Eurecat · University of Barcelona

Diagnosis Diffusion Models Gradient-Based Optimization Reverse Voxel Uncertainty

Sep 24, 2026cs.LG

Residual Correlation as a Diagnostic for Joint-Uncertainty Gains from GP Coregionalisation

In multi-target regression, correlated targets are often coupled through multi-output Gaussian processes with an intrinsic model of coregionalisation (GP-ICM), assuming that sharing statistical strength improves overall performance. In practice, the benefits are inconsistent. Across the settings studied, we find that the main benefit of coregionalisation is joint uncertainty quantification rather than point prediction. Raw target correlation does not predict when coupling helps; in the separable GP-ICM settings studied here, residual correlation, the cross-target dependence left unexplained by independent per-target predictors, is the strongest predictor of joint-uncertainty gains. We introduce a lightweight diagnostic,

D_{\rm logdet}=-\frac{1}{2}\log\det R_{\rm res}

, which represents the idealised joint negative log-likelihood (NLL) gain from modelling a full rather than diagonal residual covariance and is computable from independent GPs alone. Across a controlled synthetic study, 16 multi-target benchmarks, and frozen transformer and convolutional neural network representations for keypoint regression, point prediction remains largely unchanged (

ΔR^2\approx 0

). In contrast,

D_{\rm logdet}

strongly predicts observed ICM NLL improvements (

ρ_s=-0.83

,

p<0.001

), outperforming heuristics such as the feature-to-sample ratio. We also propose Residual-ICM, which preserves independent marginal variances while adding residual-correlation structure to the joint covariance. Residual-ICM achieves the best average joint NLL among the compared methods, while the diagnostic indicates when covariance coupling is likely to be useful. The diagnostic is specific to global Gaussian residual dependence, the structure captured by separable coregionalisation.

Fangqin Zhou, Joaquin Vanschoren

Eindhoven University of Technology

Gaussian Process Spatio-Temporal Correlations Diagnosis

Sep 24, 2026cs.CV

Not All Confusion Is Equal: A Source-Aware Uncertainty Diagnosis for Fine-Grained Aircraft Detection

Fine-grained object detectors are commonly evaluated with confusion matrices, which show where the model is confused but not why, nor whether the confusion can be reduced. We argue that confusion can be attributed to distinct, separable sources, each quantitatively measurable, turning a passive measurement into actionable guidance. We present

A^2E^2

, a diagnostic tool that decomposes the sources of confusion along two axes,

\{

aleatoric, epistemic

\} \times \{

within-class, between-class

\}

, giving a

2\times2

taxonomy that enumerates the source types. Each quadrant is measured by its own quantity, computed in one of three places (input geometry, output-space disagreement, and the bias-parameter posterior), so the two epistemic sources are separated by construction rather than by an empirical correlation. On fine-grained aircraft detection, the four quadrants become four named sources with their own remedy verdict: affinity (geometric similarity, irreducible from size alone), heterogeneity (geometrically heterogeneous sub-variants, pointing to re-labeling rather than more data), contested (an insufficiently trained but learnable boundary, improvable), and collapsed (a class starved of data, reducible). After attributing the confusion to a specific reducible source, we apply a targeted intervention and verify experimentally that it reduces the diagnosed source specifically while leaving the irreducible sources unchanged.

A^2E^2

thus turns confusion measurement into a concrete, validatable and actionable "diagnosis" in which the same off-diagonal mass can carry opposite causes and opposite remedies. We also state this framework's limits, including which sources are only partially identifiable on this specific dataset and why.

Hai Huang, Helmut Mayer

Chair of Visual Computing, Institute for Applied Computer Science, Universität der Bundeswehr München, Germany

Detection Performance Drone Detection Diagnosis Epistemology

Sep 23, 2026eess.SY

EvEMTBench: An Open Benchmark for Machine Learning in Power System Protection

Studies of machine-learning-based power system protection are difficult to compare because task definitions, measurement access, data partitions, metrics, and generalization conditions often differ. EvEMTBench addresses this gap with an open, executable, and versioned benchmark that fixes these evaluation choices while leaving model design open. Across four grids spanning 20-345 kV, it defines 12 protection and event-analysis functions instantiated as 24 scored tasks and supports structured evaluation across observability conditions, predefined distribution shifts, and zero-shot and fine-tuned cross-grid transfer. Committed partitions, leakage controls, and reproducible reporting provide a common basis for comparing future methods. A reference evaluation spanning trivial, conventional, feature-based, and deep-learning baselines shows that wider observability is not uniformly beneficial, shifted conditions can reveal failures not apparent in-distribution, and cross-grid transfer is substantially stronger for fault detection than for fault localization. Protection-relevant diagnostics identify failure modes not apparent from primary metrics alone. EvEMTBench therefore makes generalization in machine-learning-based protection an explicit and reproducible evaluation problem.

Julian Oelhaf, Georg Kordowich, Christian Bergler +3

Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91058, Germany · Institute of Electrical Energy Systems, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen 91058, Germany · Department of Electrical Engineering, Media and Computer Science, Ostbayerische Technische Hochschule Amberg-Weiden, Amberg 92224, Germany

Power Systems Fault Diagnosis Reproducibility Diagnosis

Sep 23, 2026cs.AI

Discovery of fully efficient fault indicators along a data-based diagnosis process

The integration of model-based and data-driven paradigms provides a powerful framework for fault diagnosis by combining the interpretability of analytical redundancy relations, i.e., input-output relations that are used as diagnosis indicators in model-based diagnosis, with the adaptability of learning techniques. DT4X is a recent diagnosis algorithm that uses symbolic regression to generate multivariate relations leveraging some properties of analytical redundancy relations and uses them as split functions in a decision tree. However, its symbolic regression procedure optimizes only the separation between two selected classes at each node, often fragmenting the remaining classes and degrading both interpretability and diagnosis performance. This paper introduces DT4X+, an enhanced version of DT4X that modifies the construction of training sets and the symbolic-regression loss so that expressions separate the target classes while preserving the coherence of non-target classes. The resulting relations become fully consistent with ARR properties and lead to more informative splits, improved robustness, and better performance on dynamic-system datasets. Experiments conducted on several benchmark systems demonstrate the benefits of this enhanced formulation.

Igor Bezmaternykh, Louise Travé-Massuyès, Elodie Chanthery

INSA Toulouse · LAAS-CNRS, Université de Toulouse, INSA, Toulouse, France · LAAS-DISCO, Comue de Toulouse, ANITI +1

Fault Diagnosis Diagnosis Robot Failures Data-Driven Discovery Redundancy

Sep 22, 2026cs.CV

Lessons learned from deploying imaging AI with the open PACS-AI platform

We describe deploying imaging AI at six hospitals through PACS-AI, an open self-hosted platform. The binding constraint is not model accuracy but infrastructure to route studies, display results, capture feedback, and audit what runs. At one center, angiography models completed 515 of 607 jobs (84.8%); failures reflected absent diagnostic views, and 78.1% of 638 clinician ratings were positive. Publishing honest readiness levels for every model is itself a governance practice.

Samuel Kadoury, Julie G. Hussin, Pascal Thériault-Lauzier +11

Department of Radiology, Centre Hospitalier de l'Université de Montréal (CHUM) and Centre de recherche du CHUM (CRCHUM), Montréal, QC, Canada · Department of Computer and Software Engineering, Polytechnique Montréal, Montréal, QC, Canada · Department of Medicine, Montreal Heart Institute, Université de Montréal, Montréal, QC, Canada +14

Real-World Clinical Workflows Diagnosis Healthcare Readiness Coronary Angiography

Sep 22, 2026cs.AI

When Are Aggregate Agent Traces Diagnosable? Traffic-Governed Interpretation and Calibrated Abstention

Runtime traces can appear transparent, but a closed-loop policy determines which states are visited and which failures become visible. We study a simulated hotel-pricing agent mapping time, inventory, and market state to discrete price actions under varying demand regimes. A fault may leave no aggregate trace when the policy rarely visits affected cells. We treat entry into aggregate-only fault interpretation as a diagnosability decision preceding scoring or localization. A reference-map gate requires repeated clean-policy support; a matched runtime gate then requires joint support in clean and current streams. Signal analysis occurs only after both pass. We calibrate false admission on a disjoint clean stream at the physical-component level and model detection by affected clean traffic rather than nominal cell coverage. In a frozen one-shot heldout, 55/72 (76.4%) regime-component units were reference-admitted, representing 20 physical components; 54/55 passed matched runtime admission, while the rejected unit abstained. Stable false admission was 0/20, with a one-sided exact 95% upper bound of 0.1391, meeting the frozen 0.20 criterion. Across 540 repeated unit-arm rows nested in those 20 clusters, affected clean traffic reduced negative log likelihood by 29.3% relative to cell coverage, a gain of 0.1264 nats per row (cluster-bootstrap 95% interval [0.0593, 0.1918]). Adding mask family and its interaction improved log loss by 0.0015 nats per row (one-sided upper bound 0.0066), below the frozen 0.01 practical-sufficiency margin. A development audit found that exact minimum hitting set and greedy selection chose identical supports in 12/12 scenarios because singleton evidence had resolved the conflicts. The result is a bounded rule for interpreting aggregate agent behavior: first establish exposure, then score change, and abstain when the trace cannot support the claim.

Peiying Zhu, Sidi Chang

Blossom AI San Francisco, CA, USA

Traces Fault Diagnosis Admissibility Diagnosis Airbnb Interpretation

Sep 22, 2026cs.AI

LingLan: An Advancing Traditional Chinese Medicine Diagnosis LLM with Multimodal Data

Though artificial intelligence (AI) increasingly transforms modern medicine, its integration into Traditional Chinese Medicine (TCM) has been relatively slow, primarily due to TCM's reliance on holistic, subjective diagnostic methods---namely Inspection, Auscultation and Olfaction, Inquiry, and Palpation(I-AOI-P)---which are difficult to align with quantitative, standardized medical systems. In this work, we introduce a Unification Framework for Multimodal Data (UFMD), which automatically processes tongue and pulse images into structured, clinically standard descriptions, integrating multi-source diagnostic information into a unified digital record of I-AOI-P process. Building on this structured data, we create LingLan-14B, a TCM-specific large language model fine-tuned via supervised learning to emulate the diagnostic logic and workflow of I-AOI-P process. Experimental results show that our method significantly enhances diagnostic accuracy, achieving a relative improvement of 103.5% over the baseline (62.72% vs. 30.82%) and reaching an F1-score of up to 82%.

Zheng Chen, Zhicheng Du, Haoxuan Li +2

Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China · Guangdong Provincial Laboratory of Traditional Chinese Medicine Hengqin, Guangdong, China

Multimodal Clinical Data Diagnosis Language Pairs Inspection

Sep 21, 2026cs.CV

Mobile Imaging Solutions for Medical Diagnosis: Trends and Applications

Advances in processing power, camera technologies, and mobile image analysis have made smartphones and other mobile devices, such as laptops, increasingly suitable for medical diagnosis and healthcare applications. Researchers have developed low-cost solutions for the early detection and monitoring of various health conditions, including eye and ENT diseases, malnutrition, heart rate variability, skin and oral conditions, and injuries, using images captured by non-medical devices such as smartphones and webcams. This survey examines existing research on mobile image-based medical diagnosis, with an emphasis on its potential to enable low-cost and accessible healthcare. We comparatively analyze state-of-the-art solutions across different healthcare application categories, examining their advantages and limitations. Based on this analysis, we identify desirable characteristics of mobile image-based diagnostic tools and highlight areas where existing approaches have made progress as well as areas requiring further research. We also discuss application-specific and common challenges and outline directions for future research. Overall, this study provides a comprehensive overview of mobile image-based healthcare solutions and their potential to support low-cost disease diagnosis and monitoring, particularly for underserved populations in remote and resource-constrained settings.

Syed Muhammad Ibne Zulfiker, Fariha Tabassum Islam, Md Sultanul Arifin +7

University of Toronto, Toronto, ON, Canada · University of Wisconsin-Madison, Madison, WI, USA · Virginia Tech, Blacksburg, VA, USA +6

Smartphone Photographs Diagnosis Heart Rate Camera

Sep 19, 2026stat.AP

Auditing Bayesian Graph Alignment: Diagnostic Comparisons and Reference Failure

Bayesian graph alignment estimates correspondence probabilities, but convergence of an alignment-score trace need not imply accurate correspondence marginals. We audit this gap on 240 new exact graph pairs from four source families, 240 larger pairs with 20-100 vertices, and a separate 60-case exact implementation check. Under an explicit edge-flip likelihood, we compare three samplers and score, marginal, indicator, categorical, and classifier-based diagnostics. Marginal disagreement improves error discrimination over score R-hat for the exact informed sampler, but its improvement for vanilla local sampling is uncertain. Assignment-based R* and short indicator panels are competitive; no diagnostic dominates across samplers and endpoints. At larger sizes, diagnostics predict subsequent marginal changes, not posterior error, and classification performance depends on the drift threshold. Disjoint-window and held-out-chain checks attenuate but preserve positive associations. Only 22 of 240 original reference sets pass an agreement screen. On forty failure-selected cases, eightfold SMC particle escalation does not resolve disagreement, whereas additional rejuvenation helps. Longer informed runs remain unstable. An elementary feasible-alignment bound demonstrates severely unrepresentative SMC and informed-chain scores in concentrated 100-vertex cases, independently of approximate reference consensus. We also exhibit common-start chains with near-zero disagreement despite exact marginal error near .967. These results support assignment-sensitive auditing while identifying limits of finite budgets, diagnostic rankings, and reference agreement as evidence of accuracy.

Melika Gorgi, Kourosh Mirsohi

Center for Complex Biological Systems University of California, Irvine Irvine, CA 92697, USA · Department of Computer Science University of California, Irvine Irvine, CA 92697, USA

Conditional Independence Diagnosis Probability

Sep 18, 2026cs.CV

Configurable Multi-Stage Vision Pipeline for Crop Disease and Pest Diagnosis

FarmerChat is Digital Green's farm advisory service for smallholder farmers. When something looks wrong with a crop, the farmer takes a photograph and sends it, and that photograph is the whole question: no symptom described, no crop named, often no text at all. The service has to determine whether the picture can be used, what crop it shows, and what is wrong with it, from images taken on cheap phones in a field, in poor light and with a moving camera. The system doing this today cannot be adjusted. It has no adjustable thresholds for photograph rejection, crops and problems cannot be added, and there is no confidence cut-off to set. We study about 1.16 million photographs sent to FarmerChat from Ethiopia, India, Kenya and Nigeria. The production quality gate rejected 46.8% of the images it judged, over a quarter of those reaching diagnosis returned no crop name, and 35.8% of the labelled problems filed under "disease" are pests, identifiable without the crop. We therefore split the work into three stages: a quality gate (M0), a crop detector (M1), and a disease or pest detector (M2). Route A fills all three with one fine-tuned vision-language model (Qwen3-VL-4B) answering in a single call. Route B fills each with a small specialist model (DaViT, YOLO26). We replace our production GPT-4o quality gate with a small MobileNetV3 gate at 86.9% F1 in 12 ms. On one test set scored the same way for every system, a hierarchical DaViT-Base achieves 95.41% crop accuracy against 91.46% for the production baseline. It also leads on diagnosis and never declines to answer, while every language model in the comparison leaves a large share of rows with no diagnosis. The fine-tuned model retains two capabilities the specialists do not have: one call for all three stages, and a request for a better photograph when the image cannot support an answer.

Naga Ganesh, Chandrashekar M S, Lakshmi Pedapudi +2

Digital Green

Leaf Disease Classification Precision Agriculture Tomato Diseases Computer Vision Diagnosis Openai+1

Sep 17, 2026cs.RO

A Simulation Platform for AUV Fault Recovery: Exploring LLM-Based Diagnostic Strategies

Autonomous underwater vehicles (AUVs) operating beyond reliable communications must recover from failures without human intervention. We investigate an architecture in which conventional deterministic layered control autonomy manages normal operations, while an invokable large language model (LLM) serves as a diagnostic and recovery planner when onboard anomaly detection identifies performance outside expected limits. Because language models are stochastic, rigorous evaluation requires ensemble testing rather than individual demonstrations. We present a closed-loop simulation architecture that couples real-time C vehicle software with a higher-level orchestration layer for physics-based fault injection, structured prompting, language-model interaction, mission file generation, validation, execution, and LLM-judge scoring. The framework, which we call SPAR (Simulation Platform for AUV Recovery), supports evaluation across fault realizations, prompt structures, reasoning models, and mission conditions. We vary these for a mass-shift fault over 480 SPAR trials, evaluating a frontier model and three off-the-shelf locally deployable LLMs. Model choice dominates diagnosis: the frontier model places the CG-shift mechanism in its top three hypotheses in 85-90% of trials, versus 60-78% for the best local model. Reasoning analysis indicates that local-model success is associated with following the complete diagnostic procedure, whereas weaker models often commit prematurely to elevator failure even though the actuator tracks its command. Diagnosis and operational decision performance do not appear to be coupled in this dataset. The contributions are an architecture extending unanticipated-fault recovery from detection to mitigation and an ensemble methodology for evaluating LLM-assisted mission management on low-power AUVs.

Khalid Halba, Kylie Cooper, James G. Bellingham

Exploration Robotics Laboratory, Johns Hopkins Institute for Assured Autonomy, Baltimore, MD, USA

Autonomous Underwater Vehicles Human-Centric Mission Planning Diagnosis

Sep 17, 2026stat.ML

Online Supervised Dimension Reduction with Random Features: Diagnostics and Computational Trade-offs

Accurate optimization of a supervised spectral objective need not produce an accurate population subspace or a better predictive representation. We investigate these distinctions for Online Kernel Supervised Principal Component Analysis (OKSPCA), which combines a centered cross-moment in finite random-feature coordinates with an Adam-style orthonormal basis update for an established objective. Fixed-map consistency, concentration and perturbation results describe the estimator and its exact subspace; same-target comparisons then assess the practical iterate separately. Across six predictive benchmarks, performance depends on the declared pipeline: replacing the tracker with the exact empirical target leaves the two regression deficits largely unchanged. Direct classification-rank models capture nearly all terminal objective energy on average, but a saved intermediate state exhibits substantial geometric deviation; a controlled sample-size study further separates empirical accuracy from population recovery. In distinct numerical-service workloads, exact on-request computation is faster in the tested classification settings, whereas Adam saves time relative to the tested full thin-SVD service for some dense wider-regression requests, alongside persistent geometric error. These diagnostics limit explanations based solely on terminal optimization accuracy and distinguish numerical cost from quality, rank coverage and freshness; they establish neither practical-tracker convergence nor predictive or deployment benefits from basis availability.

Zhenlin Yao, Wei Xiong

School of Statistics University of International Business and Economics Beijing, China

Principal Component Analysis Subspace Dimensionality Reduction Adam Random Diagnosis

Sep 17, 2026cs.CV

A Multi-Modal Generative Model for Tomato Disease Leaves Understanding

Artificial intelligence for plant disease analysis has advanced from task-specific classifiers to multi-modal models capable of jointly interpreting visual and textual information. However, practical deployment in precision agriculture remains limited because most existing approaches treat disease understanding as isolated prediction tasks, failing to capture the complementary relationships among symptom recognition, severity assessment, and question-driven diagnostic reasoning. In tomato pathology, accurate interpretation of diseased leaves requires more than label prediction; it demands integrating visual symptoms with semantic context to support a comprehensive and explainable understanding. Here, we present SOLAR, a multimodal generative model that understands tomato disease spanning six question-answering tasks. SOLAR learns to align visual features with task-aware language representations by Fusion Expert module based on mixture-of-expert, enabling it to generate contextually relevant answers across diverse diagnostic tasks. By formulating tomato disease analysis as a generative Visual Question Answering (VQA) task, SOLAR provides a flexible framework that supports multi-task inference within a single model while improving performance and cross-task knowledge sharing. We evaluate SOLAR on

41,677

images, including

216,209

Question-Answering (QA) pairs to understand tomato leaf disease under both closed and open-ended QA settings. Experimental results show that SOLAR consistently outperforms state-of-the-art vision-only, vision-language, and task-specific models across all tasks, demonstrating superior accuracy, robustness, and multimodal reasoning. These findings highlight the potential of generative multimodal modeling as an effective direction for understanding of plant disease. The code for this study is available at https://github.com/EnalisUs/SOLAR.

Khang Nguyen Quoc, Minh-Phuoc Tran, Gia-Han Truong +1

Tomato Diseases Multimodal Clinical Data Multimodal Generation Diagnosis Visual Generation

Sep 16, 2026cs.AI

Hyperbolic Graph Representation Learning for Differential Diagnosis on Biomedical Knowledge Graphs

Biomedical knowledge graphs combine ontology-derived hierarchies with transversal associations among heterogeneous entities such as phenotypes, diseases, genes, proteins, and patients. This hybrid structure raises the question of whether hyperbolic embeddings, which naturally capture tree-like organization, remain useful beyond purely hierarchical graphs. We present a preliminary study of hyperbolic graph representation learning for Mendelian-disease differential diagnosis on a patient-integrated biomedical graph. Experiments on isolated ontology subgraphs show that hyperbolic models achieve strong performance in substantially lower dimensions than Euclidean baselines. We then evaluate the models on a link-prediction task that ranks candidate diseases for each patient. Results suggest that hyperbolic embeddings can exploit biomedical hierarchical structure while supporting diagnostic reasoning over heterogeneous patient-level graphs.

Pietro Miotto, Lucia Mellini, Tommaso Marzi +5

Department of Computer Science, Università degli Studi di Milano, Milan, Italy · Università della Svizzera italiana (USI), Lugano, Switzerland · Politecnico di Milano, Milan, Italy +2

Biomedical Knowledge Graph Hypergraphs Hierarchical Diagnosis

Sep 16, 2026cs.AI

HPOQuest: A Rare-Disease Diagnostic Agent Using Active Phenotype Acquisition

More than 300 million people worldwide are affected by one of over 7,000 known rare diseases, yet diagnosis remains difficult because patients initially present with incomplete and heterogeneous phenotypes. We present HPOQuest, a training-free framework for sequential phenotype acquisition in rare-disease diagnosis. Starting from a small set of observed patient phenotypes, HPOQuest maintains a probabilistic disease ranking and iteratively selects informative follow-up questions to support clinicians during patient assessment. Confirmed phenotypes update the disease ranking, while all responses update the candidate question set. Across four benchmark cohorts, HPOQuest substantially improves diagnosis from sparse initial phenotypes, with gains of up to 30% points at Recall@1 and 45% points at Recall@5. These results demonstrate that sequential phenotype acquisition can substantially improve rare-disease diagnosis from limited initial clinical evidence.

Kamilia Zaripova, Nassir Navab, Azade Farshad +1

Technical University of Munich, Munich, Germany · Computational Health Center, Helmholtz Center Munich, Oberschleißheim, Germany · Munich Center for Machine Learning (MCML), Munich, Germany +2

Rare Disease Diagnosis

Sep 16, 2026cs.CL

Modeling the Developmental Shift in Telicity Acquisition

Acquiring telicity, which is the distinction between bounded (e.g., ate an apple) and unbounded (e.g., ate apples) events, requires first language (L1) learners to map surface-level and semantic cues to abstract event structures, but the computational trajectory of this mapping is not well understood. We introduce a Difference in Surprisal method that uses GPT2 token surprisal over paired temporal adverbial diagnostics (in an hour versus for an hour) to automatically label telicity across English CHILDES corpora, validated against expert linguist judgments. Using these labels, we train diagnostic logistic regression classifiers on 12 syntactic and lexical semantic features to compare how child speech and child-directed speech encode telicity. The two models diverge: the child model reaches near perfect accuracy through a single deterministic cue, the presence of a post-verbal determiner, while the adult model relies more heavily on verb class and other lexical semantic features, with the determiner cue neutralized. This trajectory supports Syntactic Bootstrapping: learners first exploit high-frequency structural cues as a scaffold to bootstrap, before developing fully compositional, verb-based event structures.

Ellie Xia, Parisa Kordjamshidi, Alan Hezao Ke

Michigan State University · University of South Carolina

Language Acquisition Developmental Trajectories Transport Diagnosis

Sep 15, 2026cs.LG

Memorisation bias in medical AI

Medical AI models hold immense potential to improve patient outcomes, but they are also known to unintentionally memorise individual records from their training datasets. While such memorisation has been linked to targeted privacy attacks, its consequences for clinical deployment, where patients may be assessed by a model that saw their historical data during training, remain poorly understood. Here we show that predictions on a patient's unseen future data can change significantly if a model observed that same patient's anonymised historical data during training, a phenomenon we term "memorisation bias". We demonstrate that this bias exists across diverse data modalities and model architectures, and over prolonged time spans: in some cases, memorisation bias persists on future records acquired decades after the historical records used for training. Moreover, in simulated prospective deployment, memorisation bias has asymmetric effects on the diagnostic accuracy of returning data contributors. When a patient returned with a de novo condition absent from their historical records in the training dataset, diagnostic sensitivity decreased significantly compared to an otherwise identical model not trained on their historical data. Conversely, when their health state was unchanged, both sensitivity and specificity were significantly inflated. Our findings reveal a previously uncharacterised risk in medical AI that arises when a model is deployed on patients who contributed to its training data. This exposes a shortcoming of current model development practice: the de-identification measures designed to protect patients' privacy make it difficult to identify returning contributors and exclude them from the AI-assisted interpretation of their own future data. Mitigating memorisation risks may thus require changes to current model training and deployment protocols.

Moritz A. Knolle, Martin J. Menten, Laurin Lux +5

Chair for AI in Healthcare and Medicine, Technical University of Munich (TUM) and TUM University Hospital, Germany. · Munich Center for Machine Learning, Germany. · Department of Computing, Imperial College London, United Kingdom. +1

Mimic-Iv Datasets Memorization Artificial Intelligence Models Diagnosis Anonymization Risk

Sep 14, 2026cs.RO

Geometry vs Structure: Graph-Based Diagnostics for LiDAR Point-Cloud Simulation Fidelity

Digital twins provide a scalable and cost-effective complement to real-world testing for validating autonomous-driving and advanced driver-assistance system (ADAS) sensor pipelines. However, quantifying their fidelity remains challenging, particularly for 3D LiDAR point clouds, where conventional geometric metrics may overlook important structural discrepancies. We present a graph-based framework for evaluating the structural fidelity of simulated LiDAR point clouds against real-world scans. While scan-level metrics such as Chamfer distance capture point-wise geometric similarity, they do not explicitly represent connectivity, topology, or object-level organization. Our framework constructs graphs from real and simulated point clouds, applies Louvain community detection to identify spatially coherent subgraphs, and matches corresponding communities using centroid proximity. For each matched pair, we compute

r_λ

, a bounded graph-spectral metric motivated by Weyl's inequality, and compare it with density-aware Chamfer distance (CDC) as a geometric baseline. Controlled perturbation experiments demonstrate that

r_λ

is invariant to rigid transformations and robust to sensor noise while remaining sensitive to structural deformation. We evaluate the framework on 50 paired real and simulated LiDAR scans acquired using a Velodyne VLP-32C sensor and CARLA, respectively. The dataset contains more than 1,000 matched communities across four representative classes: vehicles, vegetation, trees, and building walls. The results show that geometric and structural measures capture complementary aspects of simulation fidelity, supporting graph-spectral analysis as an additional diagnostic layer for validating digital twins in ADAS and autonomous-driving applications.

Ghazal Farhani, Taufiq Rahman

Automotive and Surface Transportation Research Centre, National Research Council Canada, London, Ontario, Canada.

Light Detection And Ranging Point Clouds Fidelity Autonomous Driving Performance Metric Diagnosis

Sep 14, 2026cs.AI

Potential of Artificial Intelligence Algorithms for Identification of Relevant Diagnostic and Prognostic Biomarkers of Early-Stage Liver Cancer

This study explores the use of deep learning and explainable artificial intelligence to diagnose hepatocellular carcinoma (HCC) and define effective biomarkers across five different stages of disease development using a transcriptomic biomarker HCC dataset constructed via semi-supervised learning from three source datasets. Several deep learning experiments were conducted with different feature extraction techniques and gene sets to identify the most effective features for training high-accuracy models with minimal loss. The best-performing model, using 15 selected genes with the SelectKBest algorithm, achieved 90.74% accuracy, while the model with the lowest recorded loss of 0.3187 was obtained using 20 selected genes. To address the issue of class imbalance in the dataset, a weighted training approach was conducted, and for model transparency and interpretability a SHAP-based XAI analysis provided insights into the model's decision-making, consistently finding DNAJB14 as the most influential gene. Functional validation in this study has provided compelling evidence that DNAJB14 plays an important role in the adverse properties of HCC and that its inhibition effectively reverses tumour cell migration, invasion, colony and sphere formation. The main limitation of this study is the dataset's class imbalance, and while weighted training helped mitigate this, further research and additional data are needed to guarantee model generalizability. Future studies should also explore the influence of genetic variations, environmental factors, and clinical differences on model performance across diverse populations.

Ali Bou Nassif, Darko Castven, Manar Abu Talib +4

Department of Computer Engineering, College of Computing and Informatics University of Sharjah, Sharjah, United Arab Emirates · Department of Medicine I, University Medical Center Schleswig-Holstein, University of Lubeck, Lübeck, Germany · Department of Computer Science, College of Computing and Informatics University of Sharjah, Sharjah, United Arab Emirates +1

Cholangiocarcinoma Cancer Detection Biomarker Prognostics Deep Learning Diagnosis

Sep 14, 2026cs.CV

Deep Learning-based Intelligent Diagnosis of Congenital Uterine Anomalies in 3D Ultrasound

Objective: To develop an intelligent framework, termed CUA-Net, for the automated classification of congenital uterine anomalies (CUA) without requiring coronal plane reconstruction, and to evaluate its clinical applicability. Methods: CUA-Net was built on 3D ResNet-18, equipped with a dynamic data resampling strategy to mitigate the data imbalance issue and a hard sample mining technique to fully learn from the difficult cases by loss adjustment. We further proposed the self-supervised reconstruction to comprehensively explore the volumes and the online data augmentation to refine the wrong predictions and enhance the model's generalization. We compared the CUA-Net with different deep-learning methods and junior/senior sonographers in the testing set. The evaluation metrics included accuracy, precision, recall, F1-score, micro-AUC, and macro-AUC. Results: The proposed CUA-Net exhibited satisfactory performance in both internal and external test sets. In the internal cohort, the model achieved accuracy of 93.88%, precision of 87.01%, recall of 95.92%, F1-score of 88.09%, and micro-AUC of 0.9982 and macro-AUC of 0.9997. In the external set, it maintained good performance with accuracy of 91.52%, precision of 83.27%, recall of 88.63%, F1-score of 81.49%, micro-AUC of 0.9945 and macro-AUC of 0.9990. Our CUA-Net outperformed the junior sonographers across all performance indicators and achieved performance comparable to that of the senior sonographers across most metrics. Conclusion: The CUA-Net demonstrates favorable accuracy and generalizability in classifying common CUA categories, while showing preliminary potential for recognizing less prevalent anomalies. These capabilities may help optimize clinical workflows and support more standardized diagnosis.

Yueyue Xu, Yuhao Huang, Jiaxiao Deng +11

The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China · Medical Ultrasound Image Computing (MUSIC) Lab, Shenzhen University, Shenzhen, Guangdong, China · Centre for Artificial Intelligence and Robotics, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong, China +2

Ultrasound U-Net Diagnosis

Sep 14, 2026cs.CV

Parallel Training Using a CNN-DNN Architecture for Accelerated Development of Diagnostic Models

Artificial intelligence has shown promise in assisting radiologists in imaging-based diagnosis across a wide range of diseases. Efficient training of large deep learning models is essential to cope with extremely large data sets or dynamically growing disease data, like in a pandemic like situation. In this retrospective study, we collected 300 CT scans from COVID-19 and non-COVID-19 pneumonia patients from three different centers in Germany. We investigated a hybrid CNN-DNN network model based on image decomposition and localization that naturally supports parallel and efficient training of deep learning models. In total, 156 models with three different architectures were trained to capture features at different levels resulting in 12 patient-level COVID-19 diagnosis models. Diagnostic performance as well as time saving were measured. The highest accuracy was obtained from DenseNet121 and 3D CNN models with a parallel CNN-DNN approach, resulting in

88.78\%

training,

76.67\%

validation and

76.03\%

test accuracy for the DenseNet121 with

4\times4\times1

subdomains and

87.72\%

training,

76.82\%

validation and

74.86\%

test accuracy, respectively, for the 3D CNN with

4\times4\times1

subdomains. The strongest reduction in parallel training time by a factor of

31

was observed for the 3D CNN model and

4\times4\times2

subdomains. Our parallel training approach improves efficiency as well as performance enabling rapid model development, among others crucial for pandemic preparedness.

Janine Weber-Hamacher, Astha Jaiswal, Philipp Fervers +8

Department of Mathematics and Computer Science, University of Cologne, Cologne, Germany · Center for Data and Simulation Science, University of Cologne, Germany · Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany +5

Diagnosis Radiology Report Generation

Sep 12, 2026cs.AI

Agentic Share-of-Search: A Multi-Agent AI System for Competitive Decision-Making in LLM-Mediated E-Commerce

AI shopping assistants increasingly redirect consumer discovery, creating an urgent need for tools that support seller-side competitive decision-making. We present a multi-agent AI system that automates competitive visibility measurement and root cause diagnosis in LLM-mediated ecommerce. The system introduces Agentic Share-of-Search (ASoS) as the decision target, deploys query agents across leading AI platforms, and uses a ReAct-based diagnostic agent to recommend prioritized merchandising interventions. A 100-trial ablation study, presented as a feasibility evaluation of this prototype, shows the agent recovers the ablated signal in 39% of trials (95% CI: 30.0% - 48.8%, 5.5x over chance), rising to 63.9% among high-correlation ablations.

Spandan Ghose Chowdhury

College of Computing, Georgia Institute of Technology Atlanta, Georgia, USA

Agentic Commerce Agentic Search Discovery Decisions Diagnosis

Sep 9, 2026cs.AI

TRACE: Training Reasoning Agents for Causal Exploration with Synthesized Rewards

Reinforcement learning with verifiable rewards (RLVR) has advanced language-model reasoning in domains such as mathematics and code, where objective answers are inexpensive to check. Diagnostic reasoning over complex data lacks this advantage: establishing the true cause of an anomaly often requires costly expert investigation and may remain ambiguous after the fact. We ask whether this asymmetry of verification can instead be engineered. We sample an intervention, inject it into a controlled simulator, and generate the observations it would produce. The hidden intervention provides an oracle label and objective reward, while the agent must still investigate noisy, confounded, and distributed evidence. We instantiate this approach in TRACE, a digital-advertising diagnostic environment with 12 root causes and fine-grained segment attribution. Agents investigate each episode using Python and SQL and must identify both the root cause and, when applicable, the affected segment assignment. On a held-out 235-episode test set, the strongest prompted baseline, Claude Opus 5, reaches 0.686 FullAttr@1. Supervised fine-tuning raises Qwen3.5-35B-A3B from 0.159 to 0.637, and subsequent RL with synthesized rewards reaches 0.757, outperforming all evaluated prompted baselines, including frontier closed-source models and a prompted Qwen3.5-122B-A10B model. The resulting policy also uses substantially fewer tool calls than the prompted 35B base. These results provide evidence that access to a scalable, objective training signal can be a more important constraint than model scale alone. More broadly, simulation-based verification can make otherwise ambiguous diagnostic reasoning tasks amenable to scalable reinforcement learning.

Rui Sun, Zhan Shi, Bing He

Independent Researchers

Reinforcement Learning With Verifiable Reward Reasoning Traces Traces Diagnosis Frontier Models

Sep 9, 2026cs.AI

Safe to Stop? Risk-Constrained Stopping for Sequential Clinical Diagnosis Agents

Clinical diagnosis agents must decide not only what test to request next, but also when to diagnose or defer. Existing agent benchmarks largely evaluate accuracy after fixed or unconstrained interaction, leaving autonomous stopping reliability implicit. We present Cros, a risk-constrained stopping layer combining state-wise error ranking, policy design on disjoint development splits, and LTT-style exact tests of selective diagnostic error and minimum autonomous coverage for complete sequential policies. Its finite-sample guarantee requires the candidate family, testing rule, and any randomization to be frozen before calibration labels are accessed. On a 1,834-episode MIMIC-derived abdominal-pain benchmark, the full ranker achieves exploratory state-error AUROC 0.853, compared with 0.715 for maximum class probability and 0.552 for the backbone's native stop score. On the previously viewed 367-episode evaluation split, analytically averaging over the frozen Cros weights yields 16.9% selective error at 78.8% coverage, cost 5.57, and 0.68 tests, versus 30.8% error at 100% coverage, cost 8.14, and 1.53 tests under native stopping. Forced continuation is non-monotone: error is 28.3% with HPI alone and 34.3% after full workup. However, the uniform-weight mixture ablation is cheaper on this viewed split despite missing the locked development margins, and Cros nominally satisfies the joint criterion in only 6 of 20 development resplits. Because evaluation labels were inspected during earlier development, these findings provide exploratory feasibility and audit evidence, not a confirmatory safety certificate.

Yuexin Wu, Vasile Rus

Department of Computer Science University of Memphis

Clinical Decision Support Diagnosis Receiver Operating Characteristic Area Under The Curve

Sep 3, 2026cs.CL

ESPO: Error-Structured Prompt Optimization via Diagnose, Diversify, and Stabilize

Evolutionary prompt optimizers such as GEPA suffer from prompt bloat: each iteration appends rules and caveats, producing prompts up to 3

\times

longer yet no more accurate. We trace this to three deficiencies - incomplete error observation, limited search diversity, and unreliable selection - and propose ESPO (Error-Structured Prompt Optimization), which decomposes prompt optimization into three phases: Diagnose clusters all training errors into structural patterns in one round; Propose generates candidates via four complementary strategies with independent biases; Select applies bootstrap stability selection. On seven public NLP benchmarks - Tweet, MMLU, GSM8K, HotpotQA, ScoNe, HoVer, and PUPA - ESPO improves average accuracy by

+

3.76 pp over the state-of-the-art (74.67% vs 70.91% for GEPA), matching or exceeding GEPA on every dataset while producing prompts 47% shorter (1,004 vs 1,878 chars) and faster at inference. Cross-model experiments across four additional student models (Gemma 3 12B, Mistral 14B, Qwen3 32B, Claude Haiku 4.5) show ESPO yields the best average accuracy on every model tested, with the largest gap on Qwen3 GSM8K (15.00%

\to

91.40%). A generalization bound (Appendix) grounds each phase in a corresponding term of the test-time gap, and the ablation confirms a key prediction: adding diversity without bootstrap selection actually hurts performance (

-

1.20%).

Lihao Liu, Peng Tang, Kunwar Yashraj Singh +1

AWS Agentic AI

Automatic Prompt Optimization Instruction-Tuned Models Prompt Optimization Natural Language Processing Model Selection Diagnosis

Sep 3, 2026cs.AI

Instruction Duplication as an Inference-Time Control Primitive

Procedural instruction following is a basic requirement for controllable language-model systems, especially when generated trajectories are inspected or repaired downstream. We introduce instruction duplication, a minimal black-box inference-time control that repeats only the procedural instruction, without retraining or decoding changes. Across seven instruction-tuned models, 300 medical multiple-choice questions, eight placement conditions, and 16,800 scheduled generations, moving from one to two copies raises the deterministic All-8 diagnostic--responses passing all eight observable tests--from 90.22% to 93.17% (+2.95 percentage points), eliminating 30.2% of the failures remaining after one copy. Pre-provisional TF-IDF recall rises from 73.44% to 74.81% (+1.38 points; Holm-adjusted p < .001), while final-answer accuracy remains exactly 60.21%. Premature commitment increases from 1.52% to 2.30% (p_Holm = .00536). A blinded challenge audit yields 10/30 directional confirmations, 20/30 perceptual ties, and no reversals; its prespecified 28/30 confirmation criterion is not met. Yet this distinction can matter operationally when a downstream system acts on the generated trajectory. In Answer Engineering (AE), where explicit trajectory state determines local repair, the published reason-first no-editing SSNHL endpoint was 25.1%; system-only AE was later reproduced at 84.2%, and the same trailing duplicate raised it to 97.1%. For conductive diagnostic branch preservation, the corresponding values are 58.9% published without editing, 78.6% with reproduced AE, and 73.8% with AE plus duplication--a within-AE decrease, but still 14.9 points above the no-editing baseline. Instruction duplication is therefore a low-complexity, placement-sensitive control whose practical value can emerge through the downstream system that consumes the exposed trajectory.

Victor Lavrenko

PeaceTech VC, Israel

Instruction Repetition Instruction-Tuned Models Inference-Time Steering Diagnosis

Sep 1, 2026cs.CL

Candidate Generation and Definition-Guided Verification for Sentence-Level Depression Symptom Recognition

Sentence-level recognition of depression symptoms is challenging because similar expressions can differ in symptom relevance, and language-model inference is insufficiently grounded in diagnostic definitions. This study proposes a two-stage framework separating symptom-candidate generation from definition-grounded verification. A contrastively fine-tuned sentence encoder generates a symptom candidate per sentence, and a fine-tuned language model verifies whether the candidate is present or absent using the sentence, its context, and a candidate-specific diagnostic definition, checking its judgment against that definition before answering. Evaluated against encoder, inference-based, medical, and general LLM baselines and a matched single-stage supervised classifier, the proposed pipeline attains the best accuracy and F1 scores of all methods, with rationales matching expert-authored annotations. A preliminary clinical audit indicates moderate alignment with diagnostic definitions, with explanation quality strongly dependent on prediction correctness. The results support decomposing symptom recognition into candidate generation and definition-grounded verification, though performance remains limited for rare categories.

Weiming Li, Catarina Barata, Miguel Constante +1

Institute for Systems and Robotics (ISR), LARSyS, Departamento de Bioengenharia, Instituto Superior Técnico (IST), 1049-001 Lisboa. Portugal · Institute for Systems and Robotics (ISR), LARSyS, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal · Department of Psychiatry, Hospital Beatriz Ângelo, 2674-514 Loures, Portugal

Depression Diagnosis LLM Inference Optimization Data Generation

Sep 1, 2026cond-mat.mtrl-sci

Autonomous discovery of new structure-plausibility laws for explainable and rapid crystal diagnosis and screening

Crystal generators and tool-using agents propose structures faster than density functional theory (DFT) energy and phonon calculations or experiments can assess them. Deciding which candidates merit expensive assessment is therefore the bottleneck, yet most screens test little beyond atomic overlap and give no chemical reason for failure. Here, our agents generate, test and actively refute two million candidate laws, leaving eight Plausibility Rules for Inorganic Structures (PRIS). These laws encode five mechanisms: short-range repulsion, ionic contact and packing, electrostatic balance, bond-valence conservation and crystallographic site complexity. Experimental structures satisfy our law sets at 82--99%, but satisfy Pauling's rules 2--5 together at only 6.5%. The strictest set detects 87.9% of damaged crystal structures, whereas distance cutoffs detect only 1.6--3.2%. PRIS plausibility is linearly correlated with synthesizability, so the PRIS-derived synthesis score (PSS) explainably screens 83.7% of hard-to-synthesize structures while retaining 80.7% of experimental structures. In a property-conditioned inverse-design run, PRIS and PSS can reduce the DFT validation queue by up to 67.3% and keep 99.2% of the candidates whose DFT-validated bulk moduli reach the design target. Beyond screening, PRIS explains why GNoME remains enriched in rare low-symmetry structures and reveals how wrong-element assignments in falsified crystal reports hide behind plausible coordinates. PRIS moves screening from a pass-or-fail verdict to a chemical reason for failure, showing that autonomous agents can discover, by active refutation, physicochemical laws that guide calculations and experiments.

Zhilong Song, Lixue Cheng

Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China. · IAS Center for AI for Scientific Discoveries, Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China. · Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China.

Crystal Structure Prediction Screening Physical Plausibility Diagnosis

Aug 27, 2026cs.CV

Evaluator-Dependent Patient-Adaptive ECG Lead-Channel Allocation

The diagnostic value of an ECG channel depends on the model that interprets it. We test whether adaptive acquisition retains its advantage over fixed protocols when that model changes. Two policies developed with a logistic evaluator are frozen and assessed with a masked waveform ResNet1D, using exhaustive, metric-matched fixed comparators. On PTB-XL, replacing the evaluator reverses the mean adaptive advantage in negative log-likelihood and Brier score across the tested budgets, while calibration responds less uniformly. The shift persists with common fixed references and broader training-mask exposure. Training a policy against the stronger evaluator partly recovers the lost advantage. These retrospective exploratory results show that acquisition quality cannot be assessed independently of the downstream evaluator and motivate validating adaptive policies with the model intended for diagnosis.

Xiaoyang Li, Zeyan Tao

College of Medicine and Biological Information Engineering Northeastern University, Shenyang, China

Aug 19, 2026cs.AI

Verifiable abstention makes AI leak diagnosis accountable in urban water distribution networks

Leak localization is usually evaluated as forced-choice prediction, although sparse hydraulic observations may not justify excavation. Here, we quantify a pressure-information limit and use it to recast localization as selective, evidence-gated decision-making. A physics-grounded executor falsifies competing leak, demand, sensor and valve hypotheses in a hydraulic twin. Deterministic code computes every number and every acceptance predicate; an independent large language model auditor may add a rejection but never overturn a failed check. Forced retrieval placed only 95 of 300 leaks in the correct zone. Across 550 mixed events, the gate acted on 223 (214 correct); on a third-party 33-leak benchmark, all four accepted events were correct. In a replay of 194 audited City D repairs, the pressure tier authorized five excavation recommendations, three matching the repaired district, while the district-inflow tier returned the correct district for 85 events. Observability limits with machine-checkable abstention enable auditable utility intervention.

Tianwei Mu, Yue Wang, Mingzhe Yuan +8

School of Municipal Engineering and Environment, Shenyang Jianzhu University, Shenyang 110168, China. · Guangzhou Institute of Industrial Intelligence, Guangzhou 510000, China. · Key Laboratory of Ecological Restoration of Regional Contaminated Environment, Ministry of Education, College of Environment, Shenyang University, Shenyang 110044, China. +3

Leakage Model Auditing Abstention Artificial Intelligence Detection Diagnosis Localization

Aug 13, 2026cs.SE

Memorization Diagnostics for Code LLMs Should be Scale-Aware

The extent to which large language models for code rely on memorization over genuine understanding remains highly debated. While current literature frequently reports widespread memorization, evaluating the underlying probing techniques across dense architectures reveals a severe breakdown in their utility at scale. Traditional encoder-style probes using perturbations such as synonym fuzzing or dead-code insertion struggle to expose memorization in scaled models, even on known-contaminated benchmarks, and decoder-style probes that rely on log probabilities show similar performance degradation. The specific mode of failure for these probes, particularly why such techniques disrupt smaller models but fail to impact larger ones, motivates us to untangle representation load from memorization rather than treating them as a single phenomenon. By applying invertible mathematical transforms to numeric problems, we isolate these two factors and reveal that scaled encoders successfully absorb substantial representation load while still converging on the correct family of solutions. In practical software engineering, this ability to adapt to varying surface forms is what truly matters for usability and generalizability in LLM and agentic applications. Whether a specific solution was seen during training becomes a much less pressing question because although memorization inflates scores on contaminated benchmarks, factoring out representation load makes it debatable how much we should truly care if a functional answer was originally memorized. Future evaluations must therefore be built around separating these phenomena rather than relying on methodologies that quietly entangle them.

Prateek Kumar Rajput, Abdoul Aziz Bonkoungou, Alberick Euraste Djiré +6

University of Luxembourg, Esch-sur-Alzette, Luxembourg.

Memorization Representational Capacity Diagnosis

Aug 13, 2026cs.LG

A Cloud-Edge System for Multimodal Clinical Screening in Resource-Constrained Rural Settings

Medical AI has demonstrated specialist-level diagnostic accuracy, yet these capabilities remain largely inaccessible in resource-constrained rural settings where bandwidth is scarce, compute is limited, and clinical decision-making requires integrating heterogeneous modalities. We introduce a cloud--edge collaborative architecture that addresses these constraints: lightweight, domain-specific models on the edge transform raw medical data into compact structured outputs, while a cloud LLM synthesizes these outputs into clinical summaries. An LLM-based orchestrator dynamically selects diagnostic tools based on patient context, promoting comprehensive modality coverage without processing irrelevant inputs. We evaluate on 20 multimodal clinical cases spanning cardiac, obstetric, trauma, and screening scenarios under three simulated network profiles (500,kbps--5,Mbps). The hybrid system achieves 98--99% diagnostic tool recall with 92--96% precision, matches or exceeds cloud-only baselines on clinical accuracy, and maintains bandwidth-invariant latency (25--35,s) at 4--15x lower token cost. These results highlight the role of architectural design in enabling efficient multimodal integration and improving factual grounding compared to cloud-only approaches under deployment constraints.

Hei Ting, Chan, Chenwei Wu +8

Una · University of Michigan, Ann Arbor, MI, USA · Massachusetts Institute of Technology, Cambridge, MA, USA +1

Multimodal Clinical Data Edge Platforms Resource-Constrained Edge Devices Healthcare Complementary Modalities Diagnosis

Aug 12, 2026cs.AI

Auditable agentic AI for evidence-grounded thyroid ultrasound diagnosis and reporting

Thyroid ultrasound diagnosis requires coordinated lesion localization, measurement, risk stratification and reporting, yet most AI systems address these tasks in isolation and provide limited support for clinical review. We present ThyroidXAgent, a clinician-interactive agentic AI system that coordinates specialized diagnostic tools and stores their outputs as an auditable case-level evidence record. The system was developed using OpenThyroidDB, a multicentre, multitask resource integrating approximately 0.3 million ultrasound images and 24,000 paired reports, and was evaluated on 28,458 non-overlapping test cases, including 8,721 cases from 35 centres in the private NHC-MISD-TUS cohort. Across heterogeneous datasets, ThyroidXAgent achieved a mean Dice score of 87.21 percent for nodule segmentation and a mean AUROC of 0.9466 for benign-malignant classification. The same workflow supported lymph-node metastasis prediction and follicular versus papillary thyroid carcinoma classification, with AUROCs of 0.864 and 0.805, respectively. For report generation, evidence-grounded assembly outperformed multimodal language-model baselines across three cohorts. ThyClinScore, a lesion-level clinical semantic metric introduced here, showed the strongest correlation with a location-aware language-model judge. ThyroidXAgent improved physician classification accuracy, increased report diagnostic consistency from 70.3 percent to 86.2 percent, and reduced segmentation and reporting time by 35.9 percent and 27.4 percent, respectively. These findings support auditable, clinician-correctable agentic AI for thyroid ultrasound diagnosis and reporting.

Haifan Gong, Shiyu Chen, Bodong Wang +11

School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China · School of Software Engineering, Sun Yat-sen University, Zhuhai, China · Independent Researcher, Jersey City, NJ, USA +6

Radiology Report Generation Diagnosis Report

Aug 12, 2026cs.AI

Constructing Dynamic Master Logic Models as Knowledge Graphs for Complex System Diagnostics Using Retrieval-Augmented Large Language Models

Dynamic Master Logic (DML) provides a hierarchical framework for representing system behavior by linking functional objectives to underlying structural elements. However, DML construction typically relies on expert interpretation of technical documentation, limiting scalability for complex systems. This study presents a framework for automated construction of DML models from system descriptions and their representation as Knowledge Graphs (KG-DML), using Retrieval-Augmented Generation and Large Language Models as enabling tools. Building on prior work with small-scale systems, the framework extends automated KG-DML construction and evaluation to substantially larger and more complex systems. Model construction proceeds across the DML hierarchy using targeted retrieval while preserving functional dependencies and explicit logical relationships. The resulting KG-DML supports diagnostic reasoning, safety assessment, upward failure propagation, and downward dependency tracing. A multi-level validation methodology evaluates layer-specific precision and recall, logical gate consistency, and overall structural integrity. Application to the Low-Pressure Coolant Injection system of a decommissioned Boiling Water Reactor demonstrates consistent reconstruction across repeated runs. The results show that automated KG-DML construction can transform technical documentation into executable functional models for diagnostic and reliability analysis.

Saman Marandi, Yu-Shu Hu, Mohammad Modarres

Center for Risk and Reliability, University of Maryland, 0151F Glenn L. Martin Hall, Building 088, College Park, MD 20742, United States · DML Inc., Hsinchu, Taiwan

Knowledge Graphs Diagnosis

Aug 12, 2026cs.AI

CTBench: Evaluating Troubleshooting Capabilities of AI Agents in Realistic Telecom Network Operations

Agents are increasingly considered for automating network operations and maintenance, where engineers must diagnose network faults, optimize configurations to enhance services, and reduce operational costs while acting under strict constraints. However, existing evaluations fail to accurately model real network characteristics or assess agents under partially observable telecom environments with diverse vendors, devices, protocols, and interfaces. In this paper, we introduce CTBench, a public benchmark for assessing whether an agent behaves like a competent telecom troubleshooting engineer. CTBench focuses on root cause analysis and path restoration. Each task is constructed by experts and annotated with rich task metadata, including golden evidence steps. CTBench uses expert-grounded metrics that evaluate both final answers and the diagnostic evidence. Experiments with representative harness-model combinations show that state-of-the-art agents perform very well at identifying endpoints in path-restoration tasks but, more generally, underperform in root cause analysis. In particular, agents struggle with interface state, link-layer, service-management, and other operational faults. Most importantly, even when agents produce plausible or correct final answers, they often fail to provide the evidence-grounded diagnoses required in operational practice. Our results further show that path restoration is generally more resource expensive, yet larger resource usage does not necessarily translate into better diagnosis.

Xingyu Yan, Tingting Dai, Antonio De Domenico +16

*Huawei Technologies, China · †Paris Research Center, Huawei Technologies, Boulogne-Billancourt, France · +Queen Mary University of London

Mobile Networks Optical Networks Artificial Intelligence Agents Production Agentic Systems Diagnosis

Aug 12, 2026cs.CL

Diagnosis Before Recovery: Turning Agent Failures into Selective Self-Correction

Self-correction is particularly useful when a failure constrains the next repair. Coding agents benefit from this property because compilers, tests, and execution traces turn many failures into typed recovery signals, but broad language-agent tasks often expose only a coarse task failure. This creates a tension for generic recovery playbooks: they broaden the agent's context precisely when the system needs a narrower repair interface, mixing incompatible signals for invalid actions, missing procedures, and strict-format errors. Our insight is that development-set failures can recover part of the missing diagnostic substrate by deciding which recovery interventions are admissible before test-time correction. We propose DARC, a diagnosis-guided recovery harness that profiles task-family failure modes, prunes mismatched interventions from a shared recovery library, and freezes a verifier-selected success-cost policy for deployment. This causal order makes correction selective: the harness first determines what kind of failure can be repaired, then decides how much recovery evidence to spend. In ALFWorld, AppWorld, and XBRL Finance, the same protocol yields an action-validity harness, a procedural-recovery fallback, and a format-precision retrieval policy; in each evaluated setting it improves average task performance over base agents and broad playbooks while reducing environment steps or retrieval budget. Our experiments show that failures need not trigger uniformly more context: DARC turns self-correction from prompt expansion into recovery-interface design. DARC provides a practical route toward more reliable agents in domains where compiler-like feedback is absent: making failures actionable before making contexts larger.

Pan Wang, Yihao Hu, Hang Wang +6

Ant International

Coding Agents Diagnosis Verification Framework

Aug 11, 2026cs.AI

Social Chain of Thought: A Multi-Agent Architecture Grounded in Medical Differential Diagnosis Methodology

Medical diagnostic reasoning is a high-impact use case for LLMs that carries significant implications for the health and wellbeing of users. When OpenAI (2026) reports that more than 5% of ChatGPT messages globally are healthcare-related, the transparency of these systems becomes a serious design concern. This is especially true for complex cases, where differential diagnosis often requires integrating multiple forms of specialist reasoning. Existing work has proposed multi-agent approaches to medical diagnosis, but it remains unclear when such systems are needed, why they help, and where they outperform monolithic inference. We introduce Social Chain of Thought (SCoT),a multi-round pipeline for medical differential diagnosis that structures multi-agent interaction as a deliberative framework for collabora. tive LLM reasoning. Evaluating SCoT against single-agent baselines, one-agent pipeline ablations, and best-of-n scaling, we show that its recall advantage is not reproduced by monolithic inference alone. SCoT is most successful in the hardest diagnostic cases, where multiple rounds of specialist conversation help recover ground-truth diagnoses and converge on a higher-recall differential.

Del Coburn, Scott Sanner, Dan Silver

Department of Sociology University of Toronto · Department of Mechanical & Industrial Engineering University of Toronto

Diagnosis Deliberation Single-Agent Baselines Thoughts Social Media Methodology

Aug 11, 2026cs.CV

MIRA: Medical Image Reflection for Agentic Diagnosis

Medical visual agents can use tools to inspect images and retrieve external knowledge, but indiscriminate tool use may introduce noisy or misleading evidence. Reliable diagnosis therefore requires not only acquiring additional observations, but also verifying whether tool actions are necessary and whether the resulting evidence supports the current hypothesis. We introduce MIRA (Medical Image Reflection for Agentic Diagnosis), a medical visual diagnostic framework for autonomous evidence search and reflective verification. MIRA dynamically invokes image-processing operations, including zooming, grounding, pointing, rotation, and measurement, as well as web search, while evaluating the relevance and consistency of the acquired evidence. We develop MIRA through a two-stage training strategy. First, a tool-augmented Monte Carlo Tree Search data engine explores diverse diagnostic hypotheses and jointly verifies visual grounding accuracy and semantic consistency to construct supervised fine-tuning trajectories. Second, reinforcement learning further improves decision-making through online reflective principle evolution: failure cases are distilled into candidate principles, and only principles that improve held-out rollout rewards are retained. Across nine medical visual reasoning benchmarks, MIRA achieves an average score of 64.73, improving its Qwen3-VL-8B backbone by 7.44 points. It also increases useful tool-use judgments from 56.2% to 73.8% and reduces harmful judgments from 8.9% to 1.6%. Qualitative analyses show that MIRA can re-examine evidence, correct premature conclusions, and adapt its tool-use strategy. Project page: https://MIRA-VL.github.io/

Shengzhi Wang, Jun Yang, Kai Wu +11

Tongji University · École Normale Supérieure – PSL · Nanjing University +2

Medical Visual Question Answering Diagnosis

Aug 11, 2026cs.LG

MoE Proxy Models for Low-Cost Failure Reproduction and Diagnosis in LLM RL Post-Training

Reinforcement learning (RL) post-training of large language models (LLMs) is computationally intensive and involves complex system pipelines with substantial debugging overhead. In practice, factors such as framework adaptation, numerical precision, and operator implementation can cause failures, including gradient overflow and loss divergence. Reproducing such failures directly on large models requires considerable time and computational resources. This paper systematically analyzes failures encountered during large-scale RL training on the Huawei Ascend platform, summarizes representative failure types, and identifies three model-side factors relevant to fault reproduction. Based on these factors, we propose a proxy-model construction method for low-cost fault investigation and auxiliary diagnosis. It employs structure-preserving, clustering-based expert pruning to select representative experts while retaining the model's backbone architecture, routing mechanism, and basic task capabilities. Our experimental results show that the proxy models reduce accelerator requirements by 50%-87.5% and achieve up to a 33.3x reduction in per-step NPU-hour cost, while preserving major training dynamics and reproducing fault responses consistent with the original models. Overall, the proxy models can serve as low-cost surrogates for fault reproduction, targeted validation, and auxiliary diagnosis in RL post-training.

Yikai Wang, Chuansai Zhou, Yuhang Zhou +10

State Key Laboratory for Novel Software Technology, Nanjing University, China · Huawei, China

Large Language Model Training Reinforcement Learning Post-Training Diagnosis Device

Aug 11, 2026cs.AI

RadFusion: Towards Threshold-Controllable Radiology Report Generation

Automated radiology report generation is advancing rapidly in response to the shortage of radiologists, yet unlike a perception model, existing generation models offer no control over the sensitivity-specificity trade-off of their diagnostic content. Such control is essential because clinical scenarios diverge: emergency triage prioritizes sensitivity to reduce missed findings, whereas confirmatory interpretation emphasizes specificity to limit unnecessary interventions. A single fixed report can neither adapt to these scenarios nor support the ROC-based validation widely expected for regulatory clearance. We introduce RadFusion, a framework that equips report generation with threshold controllability. Our method fuses a multi-label classifier, which provides per-disease confidence scores, with a VQA-based report generator, which describes medical findings in detail; an LLM then rewrites the report so that its stated diagnoses follow the classifier's decisions at the selected threshold while staying grounded in the generator's descriptions. On MIMIC-CXR, the performance of RadFusion conforms to the classifier's ROC curve: sweeping the threshold and mapping the reports back to class labels reproduces the classifier's validated ROC performance. This conformance makes generated reports quantitatively evaluable through ROC analysis, strengthening the case for regulatory clearance, and enables operating-point selection that matches report behavior to clinical context. Moreover, combining the two model types improves diagnostic accuracy over uncontrolled generation: sensitivity increases by 6.9% at matched specificity, and specificity by 20.7% at matched sensitivity. These results show that RadFusion makes report generation clinically adaptable, quantitatively verifiable, and diagnostically more reliable.

Ying Jin, Noel C. F. Codella, John Corring +3

Microsoft

Radiology Report Generation Report Diagnosis Area Under The Receiver Operating Characteristic Curve

Aug 10, 2026cs.CV

UniMod: Enhancing Multi-Modal Medical Diagnosis through Cross-Modality and Within-Modality Alignment

Multi-modal learning combining medical images and clinical text is promising for disease diagnosis. However, standard multi-modal training leads to shortcut learning: models exploit the easier modality (e.g., diagnostic cues in text) while neglecting harder-to-learn features (e.g., subtle visual patterns). We propose UniMod, a framework that mitigates shortcut learning by requiring each modality to predict the diagnosis on its own. It supervises image-only, text-only, and multi-modal classification simultaneously, so each modality must extract diagnostic features. We add cross-modality alignment for knowledge transfer and within-modality supervised contrastive alignment over same-diagnosis patients. On Harvard-Glaucoma, UniMod reaches 0.850 AUC, outperforming OGM-GE and Gradient Blending by 1.6-1.8%; on CheXpert Plus, it reaches 0.966 AUC, surpassing them by over 5%. UniMod also extends to 5-class multi-label diagnosis without architectural change, improving mean AUC by 0.097 over CGGM.

Zijian Gu, Weikai Lin, Shuang Zhou +2

University of Central Florida · Orlando, FL, United States · University of Rochester +5

Multimodal Clinical Data Cross-Modality Modality Alignment Medical Images Diagnosis

Aug 10, 2026cs.CV

From Diagnosis to Correction: Benchmarking and Improving Real-World Table Parsing

Recent document parsers achieve table TEDS scores above 93 on OmniDocBench v1.6, yet community feedback and our audit reveal persistent failures on complex real-world tables. To quantify this gap, we introduce TableParseMap, a diagnostic benchmark of 916 real-world tables organized into five challenging scenarios and nine failure types. The strongest evaluated parser achieves only 85.03 TEDS, showing that aggregate benchmark scores conceal substantial weaknesses. Our analysis attributes these failures to three complementary limitations: large tables exceed the reliable processing scale of a single pass, weak or ambiguous visual cues hinder structure perception, and the reconstructed table may remain visually inconsistent with the image. We therefore propose DEC (Decompose--Enhance--Correct), a visual-consistency-guided agentic framework that improves frozen table parsers without retraining. DEC uses a general VLM as the controller: Decompose partitions large tables along structure-aware boundaries, Enhance exposes weak visual evidence and reparses transformed views, and Correct diagnoses and repairs residual errors. A Visual Consistency Gate (VC-Gate) selectively triggers intervention, while a Visual Consistency Ranker (VC-Ranker) verifies candidate updates and supports rollback without ground-truth HTML at inference time. We further derive a 1,977-table Consensus-Hard Set from 4,556 candidates through offline metrics and cross-model consensus. Across three frozen parsers, DEC improves TEDS by 1.57 points on average; on TableParseMap, gains reach 1.89 points overall, 2.62 on structural errors, and 5.66 on large tables.

Jutao Xiao, Yuan Qu, Dongsheng Ma +7

Zhejiang University · Shanghai Artificial Intelligence Laboratory · 1Zhejiang University, 2Shanghai Artificial Intelligence Laboratory +3

Document Parsing Tabular Data Diagnostic Benchmark Diagnosis Correction Real-World

Aug 10, 2026cs.AI

KVDiagnosis: A Diagnostic Benchmark for KV-Cache Compression in Long-Context Language Models

KV-cache compression reduces long-context memory, but aggregate task scores reveal neither which correct executions fail nor why. We present KVDiagnosis, a diagnostic dataset and benchmark with three contributions. First, a 25-method taxonomy groups methods into five mechanism families and links them to eight verified implementations and their valid diagnostic measurements. Second, for every supported method setting, we evaluate all sources in each fixed split against a per-source FullCache control before selecting FullCache-correct/compressed-wrong (C-to-W) rows separately for each method-setting, so no compressor defines another's test set. Third, a common record format links paired outputs and run metadata to cache, likelihood, attention, and decoding measurements with explicit applicability states. On Qwen3-8B, four evidence-aware workloads yield 59 800 supported compressed runs over 2600 sources and 12 520 C-to-W rows. Under fixed diagnostic rules, 63.2% have low or partial measured/projected coverage. Only 19 rows (0.2%) combine high measured/projected coverage with strong likelihood drift; another 2,126 (17.0%) preserve structural position addressability, for which representation fidelity remains unknown, while showing the same drift. Against C-to-C success controls, all ten diagnostics separate failed from successful compression (stratified AUROC 0.684-0.871). Among 96 reproducible low-EAR failures, a controlled 4x evidence-attention boost repairs 29.2%, versus 6.3% under a count-matched sham intervention and 3.3% degradation on matched C-to-C controls. Code and data are available at https://github.com/ChosenQC/KVDiagnosis.

Chen Qiu, Ziwu Liu, Chao Fei +2

KAUST Thuwal, Saudi Arabia

Key-Value Cache Compression Diagnostic Benchmark Diagnosis Workload