Latest papers 533

38 papers in the last four weeks, up 41% on the four weeks before. 0.3% of all new papers.

Aug 14, 2026cs.AI

Removing Temporal Note Redundancy Improves Multimodal Reinforcement Learning for Medicine

Mechanical ventilation is a critical life-support intervention, requiring dynamic adjustments to ventilator settings as a patient's condition evolves. While reinforcement learning (RL) offers a promising framework for optimizing these sequential decisions, standard approaches rely primarily on structured electronic health record (EHR) data, missing crucial clinical context recorded in free-text notes. Integrating longitudinal clinical notes into RL state spaces is challenging because notes are heavily inflated by temporal redundancy, such as copy-forward text, templating, and repetitive documentation, which dilutes time-local updates and degrades state representation quality. To address this, we propose a redundancy-aware multimodal state representation framework that explicitly removes duplicated note text over time before policy learning. We evaluate two computationally efficient temporal decomposition strategies for removing duplicated note text: (1) an embedding-space decomposition using singular value decomposition on local history subspaces, and (2) an interpretable sentence-level diff operation that filters out previously documented sentences before text encoding. Using real-world ICU data, we demonstrate that state representations constructed by stripping temporal note redundancy significantly outperform both structured-only and raw-note baselines across multiple off-policy evaluation methods (Model-Based Rollouts, Fitted Q-Evaluation, Weighted Importance Sampling, and Weighted Doubly Robust Evaluation). Our findings show that explicitly isolating new clinical information from repeated note text yields higher-quality state representations and directly improves RL performance for clinical decision support.
Aug 13, 2026eess.SP

Foundation models for movement data: Are they ready for prime-time?

Foundation models (FMs) trained on large-scale accelerometer data have been proposed as general-purpose feature extractors for health monitoring, but systematic evidence of their advantages is lacking. We present the first comprehensive evaluation of four open-source accelerometer FMs against supervised baselines covering 19 tasks across the domains of activity recognition including activities of daily living, clinical monitoring, and physiological inference. We find task-dependent performance results: supervised models remain competitive with FMs on human action recognition (HAR), with no consistent advantage for either, while selected FMs lead on fall and stress detection and are the most robust to sensor-placement variation. As frozen feature extractors, FMs are strongest for demographic inference, whereas sleep staging performance remains near chance level for all models. The internal FM representations show strong similarity across layers, highlighting potential for future FM improvements. Linear and frozen probing reveals that UniMTS provides the strongest representations and is the only FM that surpasses the supervised baselines without finetuning. Concept discovery analysis shows all models capture high-intensity activities clearly but struggle with sedentary, complex or ambiguous activities. We provide scenario-based deployment recommendations. Furthermore, we identify FM-derived activity profile inference-moving beyond fixed category classification-as a promising research direction.
Aug 13, 2026cs.LG

A Cloud-Edge System for Multimodal Clinical Screening in Resource-Constrained Rural Settings

Medical AI has demonstrated specialist-level diagnostic accuracy, yet these capabilities remain largely inaccessible in resource-constrained rural settings where bandwidth is scarce, compute is limited, and clinical decision-making requires integrating heterogeneous modalities. We introduce a cloud--edge collaborative architecture that addresses these constraints: lightweight, domain-specific models on the edge transform raw medical data into compact structured outputs, while a cloud LLM synthesizes these outputs into clinical summaries. An LLM-based orchestrator dynamically selects diagnostic tools based on patient context, promoting comprehensive modality coverage without processing irrelevant inputs. We evaluate on 20 multimodal clinical cases spanning cardiac, obstetric, trauma, and screening scenarios under three simulated network profiles (500,kbps--5,Mbps). The hybrid system achieves 98--99% diagnostic tool recall with 92--96% precision, matches or exceeds cloud-only baselines on clinical accuracy, and maintains bandwidth-invariant latency (25--35,s) at 4--15x lower token cost. These results highlight the role of architectural design in enabling efficient multimodal integration and improving factual grounding compared to cloud-only approaches under deployment constraints.
Aug 12, 2026cs.AI

How Compliant is Sepsis Treatment? An Expert-Guided Neuro-symbolic Pipeline for Generating Clinical Compliance Insights

Verifying whether clinical care follows evidence-based protocols is a natural neuro-symbolic problem, yet the safety-critical setting defeats either paradigm alone. We present an expert-guided pipeline that constrains a large language model strictly to semantic normalization, mapping messy drug and microbiology strings onto a fixed clinical vocabulary, while a Sugeno fuzzy inference system reasons over the normalized events. The fuzzy layer encodes eight Surviving Sepsis Campaign bundle rules and replaces binary judgments with graded scores in [0,1]. Applied to 2,438 MIMIC-IV v3.1 sepsis episodes, it surfaces antibiotic timing as the most critical breakdown (mean 0.24, 13% within one hour), Hour-1 underperformance (mean 36.7%), a 51% elevated-lactate drop-off, and descriptive differences in ICU stay across compliance groups (3.8 versus 5.1 days).
Aug 12, 2026cs.CV

Autonomous Telerehabilitation via Skeletal Motion Prediction and Joint-Level Performance Assessment

Autonomous rehabilitation systems must not only recognize human motion but also provide structured feedback to support users without continuous therapist supervision. This paper presents a telerehabilitation pipeline that integrates skeleton-based exercise quality assessment and short-term motion prediction into a two-module system operating on marker-free RGB video. A self-attentive Bidirectional LSTM performs exercise quality classification using MMD-NCA metric learning, while a graph-based motion prediction module computes per-joint position errors between predicted and observed poses, generating spatially localized deviation signals. Each module is evaluated independently on established benchmarks: the classifier achieves 96.45% mean-class accuracy on squat sequences from the PROZIS dataset, and the adopted STARS predictor achieves a mean MPJPE of 75.8 mm at 560 ms on Human3.6M, outperforming graph and recurrent baselines across all prediction horizons. The framework is designed for eventual deployment in assistive robotics and home-based rehabilitation contexts; end-to-end integration and clinical validation are important directions for future work. By combining motion recognition and prediction in a single system, this work contributes a step toward autonomous, feedback-driven telerehabilitation, for more accessible and scalable rehabilitation solutions.
Aug 11, 2026stat.ME

Expert-Guided g-computation with Large Language Models for Estimating Causal Effects on Timings: Applications to Hospital Quality Improvement

Hospital quality improvement (QI) programs routinely face multiple candidate interventions to optimize hospital flow, but existing methods struggle to estimate and rank the causal effects of such interventions. This work focuses on one of the most standard hospital metrics, the average length of stay (LOS), and its causal estimand, the average time saved. To characterize this causal effect, qualitative approaches rely on expert judgment to map patient trajectories, making them susceptible to cognitive biases; quantitative approaches rely on data-driven models, which fail when interventions are hypothetical with no historical data or have complex causal mechanisms that require clinical reasoning rather than data alone. We propose expert-guided g-computation, or egg-computation, which combines the complementary strengths of both approaches by connecting the Gantt charts commonly used to map patient trajectories with the causal DAG literature. We introduce a causal model over Gantt charts and establish identification using a variant of g-computation that seeks expert input only for components unidentifiable from data. To make egg-computation practical, we develop an LLM-assisted pipeline that reliably scales up expert reasoning. In simulations, egg-computation outperforms conventional causal inference methods when patients have diverse causal structures and intervention mechanisms. In a study of eleven candidate QI interventions at an urban safety-net hospital, the LLM pipeline generated graphs and time-saving estimates highly concordant with those of human experts. Beyond healthcare, egg-computation is a broadly applicable framework for estimating the average time saved for candidate interventions whose causal mechanisms can be represented using Gantt charts.
Aug 10, 2026cs.CV

DoseBridge: Denoising Diffusion Bridge Model for Dose Prediction in Lung Intensity-Modulated Proton Therapy

Most radiotherapy dose-prediction models use only CT images and anatomical structures, although intensity-modulated proton therapy (IMPT) dose also depends strongly on beam geometry and available clinical datasets are often small. We present DoseBridge, a denoising diffusion bridge model that uses the patient CT as a structured bridge endpoint and encodes plan-specific beam geometry in a spatially aligned beam mask. Multiscale fusion combines CT, target, organ-at-risk, and beam-mask representations with 1.95% additional parameters. DoseBridge was retrospectively evaluated on single-institution CT images and treatment plans from 52 patients with advanced-stage lung cancer treated with 60 Gy in 30 fractions; 42 cases were used for training and 10 for testing. Performance was assessed using image-similarity, dose-volume, and Lyman-Kutcher-Burman normal-tissue complication probability (NTCP) metrics and compared with two deep-learning models. On the test cohort, DoseBridge achieved a mean absolute error of 4.170 Gy, peak signal-to-noise ratio of 23.06 dB, and structural similarity index of 0.798, outperforming both comparison models on these metrics. Clinical target volume D95 differed from the reference dose by 0.62 +/- 1.6 Gy; signed organ-at-risk mean-dose differences ranged from -0.32 to 0.24 Gy, and NTCP differences were -0.40 +/- 2.2 and 0.52 +/- 3.4 percentage points for acute esophagitis and radiation pneumonitis, respectively. Changing only the beam mask redirected predicted low-dose entrance regions while preserving the high-dose target region. To our knowledge, DoseBridge is the first denoising diffusion bridge model for radiotherapy dose prediction. These results support its feasibility as a beam-aware planning prior for lung IMPT, pending evaluation in larger external cohorts.
Aug 10, 2026cs.AI

Coupled Graph--Policy Distillation for Personalized Medication Safety in Older Adults with Multimorbidity

Large language model (LLM) agents can support medication review between clinical visits, but safe choices for older adults with multimorbidity depend on conditions, medications, and geriatric risks that users may omit. We introduce ATLAS, a coupled graph--policy distillation framework for patient-adaptive medication safety. ATLAS structures guideline evidence as a medication-safety graph. Targeted questions update the patient state and distill relevant relations into a patient-specific medication conflict graph (PMCG). A risk-first multi-agent policy uses the PMCG to screen contraindications, assess cautions and monitoring needs, identify safer alternatives, and verify the final medication plan. We also introduce GeriMedBench, an interactive benchmark that tests safety-critical information acquisition and evidence-based decision revision. Across a European non-interactive multimorbidity benchmark, an Asian interactive multimorbidity benchmark, and an Asian non-interactive cross-guideline benchmark, ATLAS achieves the strongest complete-decision performance among the compared systems. On the European non-interactive multimorbidity benchmark, it exceeds the strongest proprietary LLM baseline by 53.73 points in Strict Success Rate and 14.63 points in overall safety reasoning score (OSRS), with no unsafe recommendations under the automated evaluator. A blinded clinician evaluation gives ATLAS higher mean ratings across all five criteria and flags potentially unsafe recommendations in one ATLAS case and two Gemini cases.
Aug 8, 2026cs.AI

FemWear: A Parameter-Efficient Wearable Foundation Model for Women's Health

General-purpose wearable foundation models are pretrained on broad sensor streams and populations, but their representations are not organized around women's health. FemWear is a women's wearable foundation model, obtained by parameter-efficiently repurposing a pretrained general multimodal wearable backbone into a specialized representation for women's health. It keeps the pretrained patch projection and Transformer encoder frozen and trains 239,236 encoder parameters - 1.11% of a 21.54M-parameter encoder - through low-rank residual adapters and causal task-family heads, producing one shared longitudinal representation for menstrual, symptom, affective, sleep/recovery, autonomic, activity, and pregnancy outcomes. We evaluate six cohorts with 63 comparable primary metrics, 33 from women's-health cohorts, while retaining the 32-task OpenMHC ability-retention benchmark. On a fixed participant split over three seeds, FemWear improved cycle-phase macro-F1 by 8.15% and reduced mean absolute error for cramps, mood symptoms, and sleep problems by 9.32%, 5.80%, and 9.43%; 24-hour onset AUPRC decreased by 3.40%. A stricter 42-participant nested leave-one-participant-out audit retained positive changes for 24-hour onset (+2.87%), 72-hour onset (+6.35%), and cramps (+2.19%), while phase, mood, and sleep changes were neutral or negative and no endpoint had a strictly positive corrected confidence interval. Capacity-matched experiments beat a latest-day multilayer perceptron but not shared-GRU or multi-gate mixture-of-experts baselines. Train-only calibration reduced onset expected calibration error by 84.2-88.2% with zero temporal-nesting violations. FemWear is therefore a women's wearable foundation model: a reproducible, parameter-efficient specialization delivering targeted transfer across women's-health tasks and coherent probability outputs.
Aug 7, 2026cs.AI

From Single Chatbots to Governed Agent Ecosystems: An Agentic AI Pattern Catalogue and Orchestration Framework for Mission-Critical Hospital Information Management Systems

Hospitals are racing to embed AI, while coping with the surge in adaptation of the technology in other industries, into the triage management, documentation, scheduling, and revenue-cycle workflows, yet most deployments remain as fragmented pilots that stall at the edge of production, exposing patients and institutions to operational fragility, ungoverned risk, and mounting technical debt. At the same time, the global AI-in-healthcare market is projected to exceed nearly USD 1 trillion by 2034, according to the report of Fortune Business Insights, amplifying the financial consequences of architectural missteps and failed scaling strategies. This research proposes a compliance-first Agentic AI pattern catalogue and orchestration framework, purposely built for HIMS, moving beyond the single LLM chatbots and towards a governed ecosystem of autonomous and semi-autonomous agents. The framework extends by adding (i) a taxonomy of Agentic roles, (ii) a formal risk-stratification model that maps each pattern to risk tiers, human-in-the-loop checkpoints, and governance hooks, and (iii) a unified orchestration runtime capable of coordinating multi-agent workflows across EHR/HIMS landscapes such as Epic, Cerner, and MEDITECH. Technically the framework combines vLLM-based inference, optimized paging memory, confidential computing, and MCP based on-premise deployment, enforcing end-to-end encryption and policy-as-code controls aligned with HIPAA, GDPR, the EU AI Act, India's DPDP and DISHA Acts, ISO 27001, ISO 27002, ISO 14971 and IEC 62304. We exhibit how the proposed architecture is capable and efficient to reduce the documentation time, integration effort, and AI pilot attrition while constricting the governance and auditability, offering hospital leaders and governing authorities an urgently needed blueprint to convert AI investment into sustainable clinical, operational, and financial ROI
Aug 6, 2026cs.AI

From Siloed Algorithms to Compliance-First Agentic Platforms: A Multi-Layered Architecture for Hospital AI Systems

Hospitals are rapidly adopting artificial intelligence for triage, imaging, scheduling etc., yet most deployments remain isolated point solutions locked inside departmental silos, resulting in duplicated effort, hidden risks, and unrealized enterprise value. Despite explosive growth of AI in healthcare market and accelerating investment, an estimated 70-80% of healthcare AI pilots fail to scale, largely due to governance gaps, fragmented data, and missing integration blueprints. This research proposes a hospital-specific, compliance-first, Agentic AI architecture with multiple interoperable layers, extending existing hospital AI platform models with: (i) an Agent Orchestration Layer for multi-agent workflows across clinical, operational, and financial domains, (ii) a Compliance and Policy Layer that centralizes policy-as-code for HIPAA, GDPR, the EU AI Act, DISHA Act, India's DPDP Act, and ISO/IEC security and safety standards, and (iii) a Privacy-Preserving Data Fabric that plugs federated learning, differential privacy, and secure enclaves into real-world Hospital Information Management System (HIMS) flows. Using a synthetic but structurally realistic hospital dataset and an open, ready-to-deploy prototype implementation, this study demonstrates the end-to-end orchestration of triage risk prediction, workflow optimization, and compliance logging, achieving substantial simulated reductions in task turnaround times and manual documentation effort while maintaining policy-guarded data access. The resulting architecture offers hospital leaders a pragmatic blueprint to move from ad hoc tools to a governed, globally compliant, ROI-focused AI platform that can be tailored to on-premise, hybrid and cloud-native deployments.
Aug 6, 2026cs.CL

FormBharo: Designing and Evaluating a Voice Agent for Conversational Form Filling in Rural India

In India, almost every social benefit starts with a form, yet the people who need these benefits most are often unable to read or write. Reaching them requires a spoken conversation. Today that work falls to frontline health workers who enroll beneficiaries one at a time, a poor use of stretched capacity. We built FormBharo ("fill the form" in Hindi), a voice agent that fills a structured form over a phone call under tight latency and cost budgets by pairing Large Language Models (LLMs) with deterministic, rule-based validation and flow control. It is being piloted with ARMMAN, an NGO running large-scale maternal and child mobile-health programs in India, to enroll low-income, Hindi-speaking mothers in antenatal and postnatal care. To our knowledge, it is the first voice agent piloted to fill an enrollment form for this population. We openly release FormVoiceAgentBench, a benchmark pairing human-recorded Hindi audio with 3,760 multi-turn conversation tests across 960 simulated calls, to evaluate our agent's components (transcription, extraction, reply generation) and end-to-end form completion under real acoustic variations. Form completion drops by up to ~41 points when LLMs receive error-prone real-speech transcripts instead of reference ones. The rule-based controls recover many turn-level extraction errors, helping smaller, cheaper models match or surpass frontier models on form completion. Component performance does not predict end-to-end performance: GPT-5.5 leads turn-level extraction accuracy on reference transcripts (99.8%) but ranks lower on form completion. Since errors both propagate and cancel across the pipeline, the optimal model choice of models emerges only through end-to-end evaluation. Finally, no single model is best across accuracy, cost, and latency at once, so we use a Pareto-based weighted-sum scalarization to select a deployable configuration balancing the three.
Aug 5, 2026cs.AI

Adaptive Arena-based Contestable Argumentative Network-of-Experts for Open-Ended Care Plan Coordination

Care plan coordination demands synthesizing heterogeneous clinical, functional, and psychosocial information across multiple professional disciplines, where monolithic LLM pipelines cannot perform in a transparent or safe manner. We present CANOE (Contestable Argumentative Network-of-Experts), a multi-agent neuro-symbolic framework that addresses these limitations through five modules: complexity assessment, adaptive team recruitment, role-based argumentative computation via an Arena-based Quantitative Bipolar Argumentation Framework (A-QBAF), human-in-the-loop contestation, and care-plan synthesis. Role-specialized agents generate supporting and attacking arguments for candidate interventions; conflicts are resolved through arena-based clash resolution before acceptability scores propagate across the argumentation graph. Care planners may accept, reject, edit, or add arguments, and the framework will deterministically recompute the final plan. Evaluation on Discharge Me! and MedicalRAG using ROUGE-L, AlignScore, MEDCON F1, FKGL, and LLM-as-a-judge shows that medically fine-tuned models achieve the strongest clinical correctness and safety, while CANOE's argumentative structure provides faithful explanation and human contestability.
Aug 5, 2026cs.CL

RESPClinBench: Benchmarking Multimodal Clinical Decision-Making and Longitudinal Disease Management in Respiratory Specialty Care

Background: Respiratory specialty care requires multimodal interpretation, longitudinal risk assessment, guideline-concordant intervention, and whole-course management, which are poorly represented by examination-oriented medical benchmarks. Objective: To develop RESPClinBench, a real-world scenario-based benchmark for respiratory clinical decision-making, and evaluate seven contemporary large language models across AECOPD-PIM and PNBIM. Methods: RESPClinBench cases were adapted from de-identified respiratory clinical data. Three attending-level respiratory physicians revised cases, reference answers, and atomic clinical-action points, while one senior respiratory specialist performed cross-review and final adjudication. AECOPD-PIM comprised 427 open-ended COPD cases, and PNBIM comprised 196 multimodal pulmonary nodule cases combining chest CT with structured clinical information. Seven models generated 4,361 responses through standardized API inference with temperature 0 and a maximum output length of 8192 tokens. An automated framework calculated the final score as the arithmetic mean of atomic-action recall and rubric-based LLM-as-a-Judge assessment. Results: Across 623 cases, the mean final score was 68.58. Qwen3.6-27B ranked first overall at 71.22, Qwen3.5-397B-A17B led PNBIM at 72.48, and Qwen3.6-27B led AECOPD-PIM at 71.11. Imaging hallucination and serious medical risk occurred in 31.85% and 8.16% of PNBIM responses; medication-safety risk and serious medical risk occurred in 26.93% and 1.44% of AECOPD-PIM responses. Conclusions: RESPClinBench identifies task-specific limitations in multimodal pulmonary nodule assessment and longitudinal COPD management. Combining explicit clinical-action coverage, holistic evaluation, and independent safety flags provides a clinically grounded basis for model selection and prospective validation.
Aug 4, 2026cs.CV

Learning Biomechanically Plausible Human Motion from Sparse Radar Point Clouds

Radar-based human pose estimation has focused on improving learning algorithms while representing the body as unconstrained keypoint coordinates. We address the underexplored dimension of anatomical fidelity by integrating a full-body skeletal model into a differentiable, end-to-end trainable radar-based pose estimation framework, in which the pose network is supervised through forward kinematics while subject-specific geometry is fitted beforehand. Subject-specific body segment proportions are predicted from radar point cloud features to scale a biomechanical skeleton. A motion prediction network maps temporal radar sequences to generalized coordinates, and differentiable forward kinematics converts predicted joint angles into 3D positions. A contact classification loss encourages physically plausible foot-ground interaction. Under leave-one-subject-out cross-validation on 11 healthy participants performing rehabilitation exercises, the framework achieves 6.456 +/- 1.759 cm mean per-joint position error (MPJPE), 8.083 +/- 0.884 degrees mean per-joint angle error (MPJAE), 0.935 +/- 0.009 contact classification F1, and 3.4 +/- 1.3 % scaling error. This proof-of-concept study demonstrates the feasibility of recovering interpretable biomechanical descriptors from a single low-cost radar sensor in a controlled laboratory setting, a prerequisite for future clinical motion analysis.
Aug 4, 2026cs.AI

TumorBoard: Evidence-Grounded Multi-Agent Decision Support for Longitudinal Neuro-Oncology

Neuro-oncology decisions require coordinated interpretation of serial MRI, pathology, molecular markers, treatment history, performance status, and evolving guidelines. We present TumorBoard, a multi-agent decision-support system built around a shared longitudinal case state and an auditable claim-evidence ledger. Specialist agents for radiology, neuropathology, molecular diagnosis, guidelines, and therapy planning produce atomic claims with provenance. An adversarial critic exposes contradictions, and a safety governor releases, qualifies, or defers recommendations according to evidence sufficiency and temporal validity. On a 360-case hidden benchmark at a matched token budget, TumorBoard achieved an action F1 of 0.772 and evidence entailment of 0.914. It exceeded the strongest typed-council baseline by 3.1 percentage points (95% CI: 1.6 to 4.7, adjusted p = 0.0012), while recommendation-to-evidence coverage reached 0.927. Under evidence deletion, the system deferred 84.2% of unsafe cases and limited harmful recommendations to 5.8%. The safety governor reduced harmful release by 7.8 percentage points at a false-deferral cost of 4.3 percentage points. Ablation studies of the ledger, critic, and governor produced the predicted failure patterns, establishing structured coordination as the source of the measured multi-agent advantage.
Aug 4, 2026cs.AI

Evaluating Counterfactual Sensitivity to Patient Information in Medication-Safety Reasoning

Applying a valid medication-safety rule when its patient-specific conditions are not met can produce an incorrect decision. Existing medical evaluations largely use isolated and fixed scenarios. A model may therefore answer correctly by recalling a drug-risk association without showing that it used patient information to decide whether the rule applies. To address this gap, we introduce MedPIC-Bench, a benchmark of source-verifiable recommendations and expert-validated questions for patient-specific medication-safety reasoning. It combines guideline-following questions with paired counterfactual questions in which a controlled change in patient information changes whether a rule applies. The benchmark contains 467 questions annotated along six clinical and reasoning dimensions. Across 28 medical-specific, general, and proprietary LLMs, every model performs worse on counterfactual questions, with mean accuracy falling from 63.6% to 45.1%. Models perform well when an explicit patient attribute directly signals a familiar contraindication, but struggle when patient information must narrow or withdraw a safety warning. Model rationales often acknowledge the changed patient information, yet the final answers retain the previous safety judgment. This vulnerability persists among medical-specific LLMs, whose average CF performance trails that of general LLMs. MedPIC-Bench therefore makes conditional rule application measurable and highlights the limitations of static medication-safety accuracy for assessing patient-specific reliability.
Aug 4, 2026cs.LG

Paired Recipient-based Evaluation of Survival Prediction for Deceased Donor Kidney Transplants

There has been significant interest in using machine learning algorithms to predict kidney transplant outcomes, such as the number of years until a graft inevitably fails. These prediction algorithms could possibly be used for pre-transplant donor-recipient matching to identify more compatible donors and recipients and thus improve post-transplant outcomes. In this study, we explore the use of survival prediction models trained on deceased donor kidney transplant data from the Scientific Registry of Transplant Recipients (SRTR). We propose a novel paired recipient-based evaluation framework that compares graft outcomes between two recipients who received kidneys from the same deceased donor, allowing us to evaluate the counterfactual benefit of changing the recipient for a certain donor. We find that five different survival prediction models, ranging in complexity from linear to deep learning-based models, all result in ~60% paired recipient-based accuracy. We further translate this accuracy into an interpretable quantity of post-transplant years gained. We also highlight major limitations of the commonly used concordance index (C-index) metric for evaluating survival prediction accuracy in this setting and demonstrate that our proposed paired recipient-based accuracy metric is more clinically relevant and better reflects real-world allocation settings.
Aug 3, 2026cs.CL

Characterizing Treatment-Context Medication Evidence Across Clinic Notes and Structured EHR Medication History

Clinic notes and structured electronic health record (EHR) medication history often contain different medication information. Same-visit disagreement between these sources may result from note-side normalization errors, differences in terminology or timing, or actual differences in documentation. We developed a note-grounded approach that uses large language model (LLM) assisted reference construction, targeted and random human review, deterministic medication normalization, and semantic and temporal comparisons with structured medication history. We evaluated all normalization results on a patient-level held-out test set to limit adaptation to the study cohort. On 5,403 held-out mention rows, exact canonical agreement improved from 0.7226 with surface-exact matching to 0.8429 after lexical cleanup and curated alias mapping. In a random audit of previously unaudited rows, canonical-label agreement was 0.9210 among evaluable valid medication mentions, whereas treatment-action attribution was lower at 0.5326. In the full-cohort characterization analysis, only 16.44% of note-derived rows had same-visit exact overlap with structured medication history, but 55.17% had same-visit semantic overlap, 90.34% had same-visit or +/-30-day overlap, and only 3.97% remained in the strict no-structured-overlap bucket under broad project-level mapping. An ontology-backed sensitivity analysis further showed that held-out strict Observational Medical Outcomes Partnership (OMOP)-backed no-overlap fell from 43.99% to 36.68% after a development-derived alias supplement. These results show that note-to-structured-medication mismatch can arise from normalization errors, differences in terminology, and differences in documentation timing.
Aug 2, 2026cs.AI

Loud or Silent? A Reusable Framework for Per-Modality Failure Analysis in Multimodal Clinical AI

Multimodal clinical models are usually judged on accuracy with every modality present, but deployment removes modalities; an echocardiogram is often unavailable where an ECG is routine. Two questions then matter beyond the size of the accuracy loss: which modality was responsible, and whether the model fails loudly or silently once that modality is dropped. The distinction is per-example and modality-level, and is separate from post-hoc feature attribution (e.g. SHAP). Models are replaced often; the evaluation that answers these questions is reused. We present a model-agnostic modality-failure framework: given N modality embeddings, any mask-aware probe, and labels, it returns a per-example failure taxonomy, a per-modality complementarity matrix that attributes error to modalities, and a loud-vs-silent dropout profile separating monitorable failures from those that pass unflagged far from the decision boundary, using only deployment-observable signals. We release it as a small, unit-tested harness and validate it against planted ground truth. Across seeds it recovers that planted modality dominance and complementary subset, reports per-modality loud-vs-silent rates, and scales to a three-modality complementarity matrix; because the planted structure is known by construction, this validates recovery of per-example attribution rather than clinical performance. We then instantiate the framework on frozen EchoJEPA and HuBERT-ECG embeddings for LVEF and the EF <= 40% HFrEF gate over a paired MIMIC-IV cohort, where on the held-out test split (n = 245) dropping echo nearly doubles error. The narrow echo-to-ECG overlap that bounds cohort size is itself a deployment finding for cardiac foundation models. All of our work can be found at https://github.com/criticaldata/PRIMED-AI.
Jul 31, 2026cs.CY

From Prediction to Explainable Provider Behavior Profiles for Fraud, Waste, and Abuse Review

Claims data can show that provider behavior changed but cannot by itself explain why. Fraud, waste, and abuse (FWA) review requires identifying material behavior, locating the codes and dollars driving it, and testing plausible explanations. Forecast residuals conflate growth, service-line shifts, code maintenance, and incomplete observation with potentially concerning behavior. We instead formulate provider review as a descriptive representation problem: observed amount yijt=sitpijty_{ijt}=s_{it}p_{ijt}, where sits_{it} is provider scale and pijtp_{ijt} is procedure composition. The profile records scale history, effective-dated code lineage, clinical-family shares, first-use events, billing context, and Medicare-versus-client differences. An optional rank-32 nonnegative factorization of procedure co-occurrence adds a fixed semantic geometry for similarity and retrieval. The profile surfaces evidence for review without inferring intent or adjudicating FWA, and is one engine within Falcon's broader review system. In a ten-quarter proprietary Medicare Carrier and DME build (1.27 million providers; 9.2 million provider-quarter profiles through 2026~Q2), the semantic dictionary covers 3,641 procedures and raises recall at 10 from 36.0% to 44.4%; for high-cost rare events, recall at 50 is 56.1% versus zero for popularity. Under the governed eligibility contract, 414,093 providers enter the national review population, with 81.8% and 90.8% remaining eligible across adjacent quarters. Replication across eight client panels preserves 86.9--95.2% amount-weighted semantic coverage. Transparent descriptions thus form the core, with learned representations adding optional semantic context.
Jul 31, 2026cs.CL

Can Zero-Shot LLMs Predict Child Malnutrition? A Fairness and Temporal Robustness Study

Child malnutrition remains a major public health challenge in low- and middle-income countries, particularly in South Asia, where early identification of vulnerable children is critical for timely intervention and resource allocation. This study aims to evaluate the feasibility, fairness, and temporal robustness of using a pretrained large language model (LLM) in a zero-shot setting for child stunting prediction using population health survey data. Using Bangladesh Demographic and Health Survey (BDHS) data collected between 2007 and 2022, we transformed maternal, child, healthcare, and household characteristics into semantically interpretable prompt-based representations and evaluated GPT-4o-mini for zero-shot stunting prediction, comparing its performance against a random forest baseline and assessing fairness across demographic and socioeconomic groups as well as temporal robustness across survey waves. The results demonstrate that zero-shot inference using GPT-4o-mini achieved comparable balanced accuracy to the supervised baseline while exhibiting substantially higher sensitivity for identifying stunting cases, relatively consistent performance across child sex groups, and stable predictive behaviour across BDHS waves; however, important fairness disparities were observed across residence and household wealth categories, highlighting the need for further investigation before deployment of foundation models in public health prediction settings.
Jul 28, 2026cs.CL

CardioBench: A Real-World Data Benchmark for Evaluating Large Language Models in Clinically Authentic Cardiovascular Care Scenarios

Background: Most medical large language model (LLM) benchmarks focus on examination knowledge or isolated tasks and may not reflect the longitudinal, multimodal, and safety-critical workflow of cardiovascular care. Objective: To develop CardioBench, a real-world benchmark spanning the cardiovascular care continuum, and assess LLM performance across clinical dimensions and specialist tasks. Methods: CardioBench includes 2,263 items from 13 task-specific datasets derived from de-identified cardiovascular records and examination data. Sixteen cardiology physicians conducted annotation and reference construction, followed by cross-review from two senior cardiologists. Seven LLMs generated 15,841 outputs under standardized zero-shot settings. Open-ended tasks were evaluated using key-point coverage and holistic clinical quality, while CardioEthics was scored by accuracy. Results: GPT-5.4 achieved the highest macro-average (62.55) and item-weighted mean (62.19), followed by Gemini 3.1 Pro (59.95) and Qwen 3.6 27B (59.72). GPT-5.4 ranked first in all three dimensions. CardioAuxReport performed best (86.38), whereas CardioECGRead (17.25) and CardioEthics (17.34) were lowest. The largest gaps between holistic clinical quality and key-point coverage occurred in CardioComm (52.71), CardioEmergRescue (52.05), and CardioTreatPlan (48.80). Conclusions: To our knowledge, CardioBench is the largest real-world, multi-task benchmark for LLM evaluation across the cardiovascular care continuum and offers the broadest coverage of clinically authentic cardiology scenarios reported to date. It provides a rigorous framework for identifying model strengths, clinically important omissions, and priorities for future development.
Jul 27, 2026cs.CL

Closed-Loop Validation-Repair for Healthcare Interoperability: A Multi-Model Study of Schema Compliance in Clinical LLMs

Healthcare interoperability requires AI systems to produce structured outputs conforming to standardized schemas including ICD-10 for diagnostic coding, CPT for procedure billing, and HL7 FHIR for data exchange. While large language models demonstrate clinical reasoning capabilities, their integration into electronic health record systems faces a critical barrier: schema noncompliance. We evaluate three open-source models, Qwen2.5 7B, Llama 3.1 8B, and Gemma2 9B, via local deployment across 320 clinical scenarios spanning ten medical specialties, yielding 960 model-scenario pairs assessed under paired baseline and validation-repair conditions. First, schema noncompliance is consistent across the three model families, with baseline compliance rates ranging from 85.9 to 91.6 percent despite varying architectures and training data, suggesting shared gaps in medical training corpora rather than model-specific limitations. Second, 96 percent of validator-detected failures are representation-level format violations such as alternative medical abbreviations and code prefixes, indicating models follow clinical writing conventions but lack awareness of healthcare IT standards. Third, the validation-repair framework achieves 99.0 percent overall compliance, ranging from 98.4 to 99.4 percent across models, with most errors resolving within one or two iterations. Exact McNemar p-values below 0.001 and absolute improvements of 7.8 to 12.5 percentage points across model sizes confirm statistical significance. These results support closed-loop validation-repair as an effective system-level safeguard for healthcare interoperability, improving schema-level readiness for downstream clinical system integration.
Jul 27, 2026cs.AI

Myopia Prevention and Control 3.0: Artificial Intelligence--Driven Risk Stratification, Proactive Monitoring, and Personalized Intervention

The convergence of artificial intelligence (AI), digital sensing, and ubiquitous computing has created an unprecedented opportunity to transform myopia prevention from a reactive, population-based model into a proactive, precision-driven one. Despite evidence that half the world's population will be myopic by 2050, conventional approaches---school-based vision screening (Phase 1.0) and evidence-based risk factor management (Phase 2.0)---have proven insufficient. We review the emergence of Myopia Prevention and Control 3.0, defined by AI integration across three interconnected domains forming a closed-loop pipeline: (1) AI-driven risk stratification predicting individual-level risk through machine learning on multimodal data; (2) AI-enabled proactive monitoring via wearables, smartphones, and school screening networks; and (3) AI-powered personalized intervention with closed-loop feedback. We critically evaluate evidence across each stage, discuss challenges in data quality, model validation, ethics, and equity, and outline future directions including multimodal foundation models, digital twins, and causal machine learning.
Jul 25, 2026cs.AI

RareLens: Towards End-to-End Rare Disease Care via Aligning Divergent Large Language Model Reasoning

Rare diseases represent one of the most challenging settings for clinical decision-making, where heterogeneous presentations, sparse evidence and limited expertise create persistent uncertainty throughout the care pathway. Although artificial intelligence could help, existing systems largely address isolated tasks, particularly diagnosis, and usually rely on downstream investigations rather than information available at initial presentation. Here we show that clinical AI performance under uncertainty can be improved not by scaling a single model, but by exploiting the diversity of multiple imperfect reasoning systems. Across heterogeneous large language models, we identify divergent reasoning trajectories with complementary error patterns and develop RareLens, which learns to reconcile these perspectives into actionable decisions across four stages of rare disease care: risk screening, diagnosis, treatment planning and prognosis prediction. Built on RarelensBench, a real-world dataset of 157,525 cases spanning all 33 Orphanet categories and more than 7,000 conditions, RareLens outperformed every frontier model tested, including GPT-5, DeepSeek-R1, Claude-3.7-Sonnet and Gemini-2.5-Pro, across all stages. It achieved an area under the curve of 0.917 for screening and top-1 accuracies of 65.5% and 89.8% for diagnosis and treatment. In an external evaluation involving 1,287 cases and 23 physicians, autonomous RareLens and physicians assisted by RareLens both outperformed unaided physicians, while demonstrating that effective human-AI collaboration requires more than simply providing model outputs. These findings establish divergent model reasoning as an exploitable source of information and suggest a general strategy for building AI systems that operate reliably under high clinical uncertainty.
Jul 23, 2026cs.AI

Unsupervised Consensus-Based Anomaly Detection for Spatiotemporal Malaria Incidence in Ghana

A consensus anomaly detection framework was applied to monthly malaria surveillance data from Ghana (2014-2023) to identify atypical transmission patterns. Anomalies were highly structured in space and time. Ashanti and Northern Regions accounted for most recurrent anomalies, with persistent hotspots at Tamale, Kumasi, and Accra. A key finding was the spatial distinction between anomaly burden (cumulative cases during anomalous periods) and anomaly frequency (persistence of unusual behaviour). Tamale had the highest burden during anomalies, whereas the highest anomaly rates clustered in Ashanti districts, showing that high-burden areas are not necessarily those with the most frequent anomalous transmission. Anomalous months formed a statistically distinct group, with much higher case counts (Cohen's d=3.252d = 3.252) and large seasonal deviations (d>1.2d > 1.2) compared with normal months. Malaria burden alone provides an incomplete picture of transmission dynamics. By distinguishing where malaria is most prevalent from where transmission behaves most unusually, this framework can strengthen surveillance, prioritise investigations, and support targeted control strategies.
Jul 21, 2026math.OC

From Operations to Elderly Care Outcomes: A Thematic Review of Industrial Engineering and Decision-Support Approaches

The rapid growth of the global aging population presents severe challenges to healthcare systems, necessitating efficient, equitable, and patient-centered care models. While Industrial Engineering and Operations Research (OR) provide robust optimization and decision-support tools to address these multidimensional complexities, current applications often remain fragmented. This paper presents a thematic review of 30 seminal studies at the intersection of OR and elderly care, categorizing the literature into home healthcare operations, polypharmacy management, and clinical chronotherapy. Our analysis highlights a significant methodological evolution from static, deterministic models toward dynamic and stochastic frameworks integrated with artificial intelligence (AI). Despite these advancements, a critical translational gap persists: the current OR literature is heavily dominated by process-level optimizations, such as staff routing, and struggles to translate these operational efficiencies into measurable clinical outcomes. Furthermore, holistic models bridging the transition between hospital and community care remain critically underexplored. To develop resilient and smart healthcare systems, this study proposes a conceptual framework that shifts the research focus from isolated operational tasks to integrated, multi-level decision-making. We emphasize the critical need for robust systems analysis, human-inclusive design, and the smartification of care through emerging digital technologies - including digital twins and large language models - to successfully bridge the gap between theoretical operational metrics and tangible patient-level health outcomes.
Jul 18, 2026cs.LG

Enhancing Personalized Bladder Cancer Treatment Through Reinforcement Learning: A Recurrent Patient State Transition Decision Support Framework

Bladder cancer treatment requires personalized and adaptive decision-making, particularly for recurrent disease, where treatment effectiveness changes across successive clinical episodes. Conventional clinical decision support systems typically rely on static treatment guidelines or single-step predictive models, limiting their ability to capture disease progression over time. This paper presents a recurrent patient state-transition simulation framework for bladder cancer treatment planning that integrates predictive state-transition modeling with a Markov Decision Process (MDP) and a Deep Q-Network (DQN) reinforcement learning environment. The predictive module estimates changes in tumor characteristics following treatment, while the reinforcement learning agent sequentially optimizes treatment decisions by interacting with simulated patient trajectories. This framework enables dynamic, patient-specific treatment planning by continuously adapting recommendations to evolving clinical states. It also generates interpretable treatment trajectories and detailed simulation logs to improve transparency and support clinical decision-making. The proposed framework was evaluated against existing reinforcement learning-based treatment planning approaches. It achieved a cumulative reward of 63,918.87, an average training loss per episode of 0.0056, and a policy improvement score of 6.62%, demonstrating effective sequential learning and robust treatment optimization in a simulated recurrent treatment environment. These findings highlight the potential of recurrent patient state-transition simulation with reinforcement learning as a flexible decision-support framework for personalized bladder cancer treatment planning and AI-assisted precision oncology.
Jul 16, 2026cs.CV

3D Geometric Tooth Alignment Planning via Deep Reinforcement Learning

3D geometric tooth alignment planning, which determines sequential trajectories from initial malocclusion to the final target alignment, is a cornerstone of modern digital orthodontics. This paper presents a novel deep reinforcement learning (DRL) framework to automate the generation of these alignment paths. We formulate the planning process as a Markov Decision Process (MDP) to capture its sequential decision-making nature, focusing on optimizing geometric trajectories while integrating essential spatial constraints, such as inter-dental collision avoidance and path efficiency. The proposed method leverages the Deep Deterministic Policy Gradient (DDPG) algorithm, enhanced by three key innovations: (1) a Transformer-based agent to model complex spatial interactions between teeth and manage high-dimensional state-action spaces; (2) a dynamic masking scheme that restricts movement to a sparse subset of teeth per step, better reflecting the clinical logic of sequential alignment; and (3) a two-stage curriculum learning strategy that gradually increases task difficulty to ensure training stability and efficient path discovery. We evaluate our approach on a dataset of 10K expert-designed treatment plans based on clinical data. Experimental results demonstrate that our method outperforms existing baselines in terms of path safety and geometric efficiency, providing a robust and automated solution for 3D geometric orthodontic alignment planning.