LLM Agent Orchestration

As telecommunication networks evolve toward autonomous 5G-Advanced and 6G operations, agentic artificial intelligence (AI) workflows, where large language models (LLMs) execute multi-step reasoning, invoke diagnostic tools, retrieve domain knowledge, and coordinate across agent teams, are increasingly embedded across the edge-cloud continuum. While the biological brain accomplishes complex cognition on an exceptionally modest metabolic power budget of approximately 20W contemporary LLMs are profoundly energy- and memory-intensive, making sustainable lifecycle orchestration a critical operational priority. However, existing AI lifecycle metrics evaluate only isolated, single-model inferences or overlook multi-agent execution graphs entirely. Consequently, network operators lack foundational models to determine whether distributed agent communication incurs meaningful energy costs and where across edge-cloud tiers agent teams should physically reside. To address this gap, we introduce agentic-eCAL, generalizing the Energy Cost of AI Lifecycle (eCAL) metric to directed multi-agent workflows by coupling a closed-form two-rate single-call energy model (compute-bound prefill and memory-bound decode) with 7-layer OSI data transport. Grounded in hundreds of GPU benchmark configurations on NVIDIA A100 and H100, 16 open-weight models and 8 orchestration topologies, we validate components of the metric and study workflow placement implications. Our findings demonstrate that inter-agent text transport incurs 0.25% of workflow energy across 5G RAN, metro, and optical links. Therefore in edge-cloud agent placement the dominant energy cost of distribution is often not the transmission of inter-agent text itself, but the additional inference and context processing induced by that communication.

The emergence of large language models (LLMs) and large multimodal models (LMMs) has enabled a new class of agentic systems capable of integrating natural language understanding with tool-based execution. In geographic information systems (GIS), this shift is transforming traditional, expert-driven workflows into semiautonomous systems that can interpret user intent, construct spatial workflows, and execute geospatial analysis tasks. However, existing approaches remain limited by fragmented integration of reasoning, execution, and evaluation, particularly in complex, real-world environments. This study synthesizes recent advances in agentic GIS frameworks, benchmarks, and surveys to identify limitations in spatial reasoning, execution robustness, validation, governance, and evaluation. Building on these insights, it introduces ANASSA (Autonomous Neural Agents for Spatial Systems Architecture), an agentic AI orchestration framework that integrates structured spatial reasoning, multi-agent workflow orchestration, execution feedback, authoritative spatial validation, provenance, uncertainty handling, and human decision authority within a unified system design. The contribution is an architecture-level specification: eleven components across four layers, a six-step Geospatial AI Cognitive Loop, cross-component contracts, and governance mechanisms intended to make agentic geospatial workflows traceable, reproducible, and accountable. Empirical performance evaluation is reserved for implementation and deployment studies.

Routing and cascades reduce tool-agent cost by transferring control across models, but stateful handoffs must preserve accepted choices, realized effects, and unfinished obligations. We formulate this as commitment-constrained residual completion and introduce Commitment-Frontier Residual Completion (CFRC). CFRC enforces target-before-proposal, whole-proposal-before-authority, and live-evidence-before-success: it freezes a residual contract from accepted progress, closes the successor continuation into an evidence-linked graph, and admits execution only when the remainder is covered, with live receipts discharging obligations. We establish contract-relative partial correctness, which extends to the original residual request under complete contract construction. Across five environments and two same-provider model pairs, CFRC achieves comparable macro accuracy to strong full-task agents at only 22.0%-34.6% of their inference cost, with additional cross-provider results demonstrating broader transfer.

This paper presents SurgicalRoomAgent, a voice-interactive multi-agent system for smart operating rooms based on large language models (LLMs). The system achieves natural language understanding, device control, intraoperative recording, and surgical report generation through a layered architecture comprising a voice interaction pipeline (wake, ASR, turn detection, agent reasoning, TTS) and an agent core (skill registry, task planner, device manager). Three key technologies are investigated: (1) KV Cache prefix warming for low-latency inference, reducing recomputation overhead from approximately 500 ms to tens of milliseconds via byte-level Longest Common Prefix reuse; (2) streaming partial JSON parsing with early parallel task execution, reducing end-to-end latency by approximately 30%; and (3) progressive skill prompt disclosure, which dynamically filters system prompts based on user role, connected devices, and surgical phase to maximize information density within limited context windows. The system is implemented using the Qwen3-27B model with llama.cpp/sglang inference engines. Experimental analysis demonstrates effective operation within a 16,384-token context limit and multi-device parallel control response times meeting OR real-time requirements.

How can language model agents effectively leverage libraries of reusable knowledge to solve long-horizon tasks? Recent work has increasingly focused on agent skills: reusable capabilities represented as skill packages, i.e., multi-file bundles containing instructions, scripts, and other resources that help agents perform specific tasks. Agent skills are typically executed by loading their skill instructions into an agent's context and relying on the agent to follow them. As task horizons grow, however, this approach becomes increasingly brittle, because reasoning quality degrades as more information accumulates in the context window. We investigate an alternative approach in which skill packages are instead invoked as subagents. Rather than loading skill instructions into the main context, subagent execution spawns fresh context windows dedicated to solving individual subtasks. We show that subagent execution outperforms agent-skill execution when skill packages expose clear input-output contracts and their instructions encode the procedural knowledge needed to fulfill those contracts. The tradeoff is additional communication overhead, as extra tokens are required to coordinate between the main agent and its subagents. Our results show that the benefit of reusable knowledge depends not only on its content, but also on how it is organized and invoked.

Scientific workflow management (WMSs) systems automate execution, yet orchestrate using fixed, hand-tuned rules. LLM agents promise more autonomous orchestration, but it remains unclear where to introduce agentic reasoning, how to bound its risk, and when it actually helps. We present Avatar, an actor-based architecture comprising an orchestrator, an executor, and a provenance monitor. Each actor's decision policy is pluggable (rule-based or LLM-backed) via a single adapter-validated action catalog, so conventional and agentic control run on the same core across different WMSs. We present an implementation using the Academy framework and evaluate Avatar across three workloads. We observe that Avatar's rule mode reproduces native execution, with a single unchanged core running all three. Moreover, LLM-backed Avatar reports a reduction of compute wastage by $55\%$ and cuts GPU-busy time by $40\%$. Overall, we envision Avatar as a step toward workflow systems that reason about their own orchestration rather than follow pre-fixed rules.

Compound LLM systems often solve a coordination problem by adding a higher-level LLM. The resulting meta-agent reads workers' outputs, writes the final answer, allocates later calls, and decides when to stop. It is expressive, but it also concentrates three control decisions in an opaque, order-sensitive model call. We ask whether the manager needs to be generative at all. UnitBoost replaces that model with a defined meta-level operator: a task-given unit map turns worker outputs into slot-value proposals, a constrained argmax assembles the output, and the slots left unfilled or unsupported become an explicit residual for the next round. The operator is order-free, records unit provenance, and gives a simple guarantee: without coupling constraints, unit-wise maximization under the same admission score dominates selection of any complete candidate. On three held-out benchmarks, it exceeds the best single candidate chosen with gold labels by 0.060-0.195 absolute task-score points and input-matched generative managers by 0.048-0.076. Replacing only the management step improves six compound-system configurations by 0.013-0.182. Residual-directed rounds raise FanOutQA cell F1 from 0.4778 to 0.5524; matched controls show that the true residual outperforms random targets and ordinary rereading, while a label-free supply signal flags exhaustion after one unproductive round. The same analysis measures three conditions in which no such gain is available (one indivisible unit, unavailable unit identity, and an endpoint that charges for every emitted unit) and quantifies cross-unit coupling as a repair cost. The manager gives up semantic freedom and gains order invariance, unit provenance, and testable failure conditions.

Ensuring the safety of autonomous driving is a critical challenge. Scenario-based testing is a systematic process used to validate Autonomous Driving Systems (ADSs), but it remains a fragmented modular pipeline in which scenario generation, retrieval, modification, ADS execution, and results analysis are performed by separate tools with little interaction. Large Language Model (LLM) agents have shown promise across ADS sub-systems such as perception, planning, and control. However, no prior work covers the whole scenario-based testing pipeline for ADSs with a unified LLM-agent framework. We present PlannerForge, an LLM-agent framework that extends all scenario-based testing stages (from Scenario Generation to ADS Assessment) and adds two further LLM-enhanced stages: ADS Enhancement and ADS Benchmarking. We evaluate PlannerForge with 10 off-the-shelf LLMs across all tasks (Generation, Selection, Modification, Module Routing, Planner Testing, and Enhancement) under 5 prompt conditions. Best-per-task scores range from 0.88 to 1.00, and open-source 20-35B backends match commercial APIs on most tasks. Open-source models such as Qwen3.6:35B match commercial APIs on three of the five tasks. Chaining the modules end-to-end retains 83% / 78% of seed queries (commercial / open). It outperforms Scenario Factory 2.0 (Finkeldei et al., 2025) on natural-language generation (193 vs. 144 executable of 200) and realises 92-96% of requested city, road and vehicle attributes. It outperforms BM25 (Robertson and Zaragoza, 2009) at rank 1 selection (92.0% vs. 67.5%) and From-Words-to-Collisions (Gao et al., 2025) on physically valid edits (>=94% vs. 31%). At N=400, cost-tuning lifts planner success from 50.4% to 70.2% and cuts collisions from 19.0% to 8.4%, without domain-specific fine-tuning.

Self-driving laboratories (SDLs) combine automated experimentation with adaptive decision-making to accelerate scientific discovery. Their operation nevertheless often depends on human specialists who translate scientific objectives into executable closed-loop campaigns. Specialists adjust them as data and operating conditions change. Here, we present La Agente 'Optima, an agentic framework that constructs and supervises Bayesian optimization campaigns across computational and experimental systems while maintaining a persistent optimization state. By separating large language model (LLM) reasoning from executed campaigns, 'Optima runs repetitive optimization loops consistently, returns control to the agent only when progress requires interpretation or campaign revision, and keeps every decision auditable. We evaluate 'Optima across ablation studies, five digital discovery tasks, and two physical platforms. Throughout, 'Optima maintained executable campaigns as both the scientific problem and execution environment evolved. In a closed-loop contact angle optimization campaign, 'Optima identified and corrected a mid-run measurement failure, bringing the contact angle from 71.4 to 67.8 degrees, just above the 64-66 degree range. From this result, 'Optima correctly inferred that the target was likely unattainable with the available reagents and recommended changing the formulation. In a five-day multi-objective flow-chemistry campaign, 'Optima increased the yield from 30% to 59% over 23 experiments. Despite substantial inference costs, it cost less and used substantially less starting material than a human-directed campaign, while selecting a more mass-efficient operating point. These results show that LLM-based agents can make rigorous, long-running optimization campaigns accessible to domain scientists without specialist setup, expanding the scope of SDLs.

Conversational assistants can blend retrieval, action selection, escalation, and wording in a single model path, or separate those roles. We report a production migration of a customer-support assistant at a large accommodation marketplace (millions of conversations per month, 11 languages, 10-second P90). Dynamic Response (DR) replaces a single Qwen3-235B-A22B blended responder with a bounded ReAct orchestrator over typed tools plus a smaller generator that writes from a backend-validated context contract. Because the migration also changed prompts, alignment, and serving, we attribute each effect to its cause and claim as architecture effects only those measured on identical replayed turns: typed entity selection moves the reservation selector to a precision-first operating point (precision 8.3% to 89.1%, recall 75.2% to 67.3%), and typed action IDs with a membership check remove observed structured-action hallucination (2.14% to 0.0%). A low-ramp A/B test reproduces the replay escalation reductions: hard-escalation responses fall from 5.60% to 3.08% and soft-escalation responses from 9.56% to 2.49%, while production handoff volume holds roughly steady; self-solve is directional (+5.1 points, 95% CI [-2, +12]). Serving optimizations cut orchestrator P90 latency from 3.87s to 2.24s on a GPU footprint reduced by roughly one-third, and self-hosting reduces estimated annual model-serving cost by more than an order of magnitude.

Retail supply chain operations rely on coupled decision modules that must adapt as requirements evolve. LLMs offer a natural-language interface for this task, but existing methods primarily focus on individual optimization models. Extending them to heterogeneous decision pipelines is challenging because a requirement may admit multiple intervention paths with different downstream effects. We formulate requirement-driven adaptation as the joint selection of an intervention route and an admissible module-level change, and propose a graph-constrained agentic framework in which domain agents expose admissible reformulation interfaces and a central processor searches over bounded intervention paths. Candidates are validated and compared using downstream KPIs. In collaboration with a large retail partner, we evaluate 100 warehouse requirements elicited from practitioner interviews, with GPT, Qwen, and DeepSeek as base LLMs. Relative to direct LLM reformulation, our framework improves correctness and end-to-end success across all three models, raising end-to-end success from 72--76% to 79--83%.

Large language models (LLMs) augmented with external tools have demonstrated remarkable capability in solving complex real-world tasks. However, existing approaches suffer from two key challenges: brittle multi-step and multi-turn reasoning caused by incompatible tool output types and API schemas, and performance degradation under large tool catalogues. To address these, we introduce \textbf{Tool Primitives}, a design that replaces rigid API schema-based invocation with natural language as the interface for tool calling, where each tool is wrapped with an LLM interface that handles schema resolution and execution internally, enabling natural inter-tool communication for nested and multi-turn tool calling. Building on Tool Primitives, we host \textbf{ToolFace}, a centralized repository of 25,519 functions from which LLMs dynamically retrieve only the relevant tools at inference time, eliminating the need to enumerate raw API schemas in context. To orchestrate Tool Primitives and ToolFace reliably in complex settings, we further propose \textbf{HEART}, a \textbf{H}arness \textbf{E}ngineering framework via \textbf{A}gent-native, \textbf{R}eusable \textbf{T}ool Primitives, comprising a Planner, Router, and Verifier that jointly support dynamic tool invocation planning, multi-step execution, and feedback-driven recovery. Experiments on five benchmarks demonstrate that HEART outperforms SFT-based models by $10\%$ on average and surpasses GPT-5.4, Claude-4.6-Sonnet, and Gemini-3.1-Pro by $6\%$ on average while reducing API cost by up to $85\%$. On 50 real-world tasks, HEART achieves $84\%$ task completion, $3.8\times$ the average of three frontier commercial models ($22\%$).

Prompt optimization can improve multi-agent LLM systems, but the prompts being optimized often serve two entangled roles: generating task-relevant content and specifying execution-critical protocols, such as message routing, output formatting, and termination signals, on which the underlying code relies. As a result, a prompt edit intended to improve content generation can inadvertently corrupt the protocol and cause the entire agent pipeline to fail. Our key observation is that these two roles have different representations: execution protocols are typically structured, while task-relevant content is usually expressed in unstructured language. Based on this, we propose control-data flow separation, where execution-critical control is represented as typed, validated program objects, while task-relevant language remains the optimizable data flow for agent communication. This design allows optimizers to improve multi-agent behavior without exposing the routing or formatting interface to prompt drift. Across synthetic reasoning, collaborative review generation, and insurance rating workflows, our framework empirically achieves 100% eventual protocol validity while consistently improving task performance.

Command-line coding agents (e.g., Claude Code, Gemini CLI) can already read and write files and sustain long sessions, yet end-to-end research still fragments across chat tools, IDEs, terminals, and writing environments, and the decisions that make it auditable are rarely preserved. We present Dr. Claw, an open-source workspace that wraps existing coding-agent executors in a controllable and auditable human-in-the-loop workflow rather than introducing another autonomous agent. Persistent state objects, a reusable skill library, and multi-executor coordination link human decisions to AI execution, turning planning, execution, and writing into one traceable, recoverable loop. We demonstrate Dr. Claw through an interactive three-view scenario and a failure-recovery walkthrough, and evaluate it against a bare command-line agent sharing the same backend executor, so the comparison contrasts the whole orchestration layer (task graph, state objects, and skill library) with the agent it wraps. Holding the executor fixed, Dr. Claw scores higher on research completeness while persisting an auditable, recoverable process trail. Demo access: repository https://github.com/OpenLAIR/dr-claw, released under AGPL-3.0 with GPL-3.0 upstream components.

Large language model-based multi-agent systems are evolving from fixed interaction topologies toward dynamically orchestrated Agent Swarms. However, existing benchmarks are still largely based on single-agent or general-purpose agent tasks, making it difficult to systematically evaluate key orchestration capabilities. We propose SwarmBench, a benchmark that evaluates model performance from multiple perspectives, including accuracy, efficiency, cost, and process quality. Experimental results show that current models exhibit substantial differences in orchestration capability. These differences are reflected not only in final accuracy, efficiency, and cost, but also in the overall quality of the orchestration process itself. Based on these findings, we further propose SwarmExp, a simple yet effective method based on experience extraction and experience replay, which consistently improves the orchestration performance of large language models.

A robot's effective ``mind'' need not reside in a single policy. It can emerge when specialized components perceive, reason, predict, act, verify, and remember within a shared orchestration process. EMERGE-Policy turns this perspective into a graph-structured agentic framework that coordinates both capability invocation and information exchange. A Main Agent retains task-level state within an active context window, while role-specific Sub Agents process perception, execution monitoring, verification, and memory consolidation in isolated contexts and return structured, task-relevant evidence. Role-specific contexts control information load by exposing only decision-relevant evidence to the Main Agent, while the functional Skill interface composes heterogeneous backends as Operational, Imagination, and Evaluation Skills. Criterion-grounded verification, textual failure diagnosis, and Branch Stack recovery provide localized correction, with token-aware external memory preserving task-relevant state. Together, their closed-loop interaction realizes the system-level policy captured by the name EMERGE-Policy. Without additional fine-tuning, we achieved outstanding performance on several public benchmark that have had a wide-reaching impact, and conducted a series of real robot experiments. These system-level results suggest that through the division of different functional sub-tasks among multiple agents and their concurrent collaboration, as well as the technical paradigm where the model is regarded as a skill and called within the framework, EMERGE-Policy can extend the robust robot policies beyond isolated runs.

Modern video generators excel at synthesizing individual clips, but complete video production requires coordinating a long sequence of interdependent creative steps, including scripting, storyboarding, generation, and editing. It further demands persistent asset management and dynamic task orchestration as intermediate outputs, dependencies, and execution states evolve over time. Existing automated systems typically rely on rigid pipelines that are difficult to adapt to diverse inputs and changing workflows, while general-purpose large language models (LLMs) remain unreliable for long-horizon orchestration and multimodal asset routing. We introduce FRAMEWORKERS, a task-centric and workspace-grounded multi-agent framework for open-ended video production. A central Director formulates video creation as dynamic task management, continuously editing a Task Stack to determine which subtask to execute next and which sub-agent to invoke. An Assistant serves as the execution layer, grounding each selected task in a shared Workspace, retrieving the required assets and context, invoking the assigned sub-agent, and persisting the resulting artifacts. Execution capabilities are exposed through modular sub-agents with registered descriptors, allowing new sub-agents to be integrated without redesigning the orchestration workflow. To improve orchestration reliability, we fine-tune the Director via supervised fine-tuning (SFT) followed by Group Relative Policy Optimization (GRPO) for descriptor-conditioned task routing. Experiments show that FRAMEWORKERS outperforms strong LLM planners in routing accuracy, recovers reliably from runtime failures, generalizes to unseen sub-agents without retraining, and achieves higher end-to-end video quality and broader task coverage than fixed pipelines, single-agent systems, and prior multi-agent approaches.

Autonomous large language model (LLM) agents increasingly face reliability, context consumption, and execution stability bottlenecks when deployed on complex, long-horizon tasks. While monolithic prompt engineering and stateless tool-calling paradigms struggle to scale, the field is rapidly converging toward \emph{agentic skills}: modular procedural abstractions that externalize execution knowledge into reusable, executable, and portable artifacts. This paper establishes a unified systems foundation and reference architecture for the agentic skills ecosystem. We formalize skills as externalized procedural knowledge bridging high-level cognitive planning with deterministic execution environments, and systematically delineate the architecture across a nine-stage lifecycle: autonomous discovery, authoring and representation formats, memory storage, dynamic retrieval and routing, composition and orchestration, execution and repair, lifelong adaptation, empirical evaluation, and security governance. We further examine marketplace dynamics, public registries, and emerging adversarial threat vectors, alongside runtime verification and defense mechanisms. Finally, we categorize system implementations across software engineering, operating system navigation, embodied robotics, and scientific discovery, while highlighting critical open challenges in continual learning and benchmark realism. This work establishes agentic skills as a foundational paradigm for building scalable, robust, and verifiable autonomous language agents.

Reliable deployment of LLM agents in user-facing products depends not on raw task-solving ability but on consistency and limit-awareness: behaving the same way across repeated trials, and recognizing when a request cannot, or cannot yet, be safely fulfilled. CAR-bench exposes this reliability gap in the domain of in-car assistants: an LLM-simulated user issues incomplete or ambiguous requests, requiring the agent to resolve uncertainty through multi-turn dialogue and tool use while strictly adhering to domain policies. Even frontier models show a substantial gap between what they can solve at least once (Pass@3) and what they solve consistently across trials (Pass^k). We bridge this gap with TRACE (TRAjectory-Contrastive Evolution), which iteratively improves a skill-based agent's behavioral knowledge without modifying model weights. This knowledge is organized as a Skill Bank of modular, retrievable skills, each encoding a self-contained set of tool-use rules and behavioral guidelines. TRACE evolves this bank through an agentic self-evolution loop: after each evaluation round, it groups trajectories by the skills invoked and refines each skill by contrasting successful and failed behaviors. The updated bank then guides subsequent rounds, while during deployment the Actor performs state-conditioned skill orchestration at every turn. On GPT-5.5, TRACE improves consistency (Pass^3) by 34.6 points, from 59.9% to 94.5%, while shrinking the gap between potential and reliable performance to just 4.0 points. On the official hidden set, TRACE achieved first place using GPT-5.6-Sol, attaining a Pass^3 score of 70%-a 40% relative improvement over the baseline. These results show that TRACE converts high model potential into stable, consistent performance gain. Project homepage: https://darwin-agent.github.io/Car-bench-TRACE.

We present Multi-Agent Reasoning and Coordination (MARC), an open-source framework that replaces monolithic LLM prompting with deterministic multi-agent orchestration for clinical reasoning. MARC coordinates role-specialized agents for extraction, reasoning, answer generation, and evaluation, with explicit context passing and traceable intermediate outputs, enabling stage-wise failure attribution. We additionally introduce a Decomposer module that generates task-specific agent prompts from a plain-language description, eliminating manual prompt engineering. The framework supports both API-based and local CPU-compatible deployments and is entirely configurable via YAML, without code modifications. MARC is designed to be model-agnostic, interpretable, and accessible to clinical domain experts without programming expertise. The full framework is available at https://github.com/Penn-RAIL/MARC-v1.

LLM-agent services repeatedly execute small deterministic transitions between model and tool calls: route an outcome, update state, and emit the next effect. We ask when this control path exposes enough concurrent work for GPU execution, and what changes when a GPU-computed route decision remains on device. We formalize the ready-cohort boundary using fixed-partition share F, exact offline share P*, local upper bound U, and online achieved share A. Under zero service time, unlimited capacity, and equal relative launch deadlines, a specialized dynamic program computes P* exactly. In a stationary Poisson replay of one pinned 851-session public trace panel, the primary condition at 100,000 target active sessions, K=256, and a 50 ms launch deadline gives F=30.19%, P*=43.00%, and U=45.85%. Exact packing recovers 81.83% of the opportunity lost at fixed window boundaries. The outcome-derived route key is a conditioning proxy, not proof of executable identity. A separate mechanism study keeps a GPU-computed binary decision on device instead of returning four bytes to the host and redispatching. Across four named GPU placements, the device-resident path is faster in all 36 configurations; within-placement row-median ratios range from 1.19x to 2.39x. Across both admissible mechanisms, all 14,557,440 tested batched invocations match a separately implemented host oracle. A fixed nested device graph that removes no host decision is slower in all 60 configurations across five placements. Together, the studies establish two measurable gates for GPU agent control: deadline-feasible cohort supply and observation placement. A joined finite online runtime is required to measure A, CPU displacement, and service-level benefit.

Hit-to-lead optimization requires iterative design of hit analogs across competing potency, selectivity, physicochemical, pharmacokinetic, safety, and synthetic constraints. We present SABLE (Synthetically-accessible Agentic Bayesian Ligand Exploration), an open-source framework that employs natural-language orchestration to guide chemical structure optimization. SABLE uses an LLM to interpret user-defined goals and route tasks, while specialized tools perform reaction-templated analog enumeration, physicochemical and ADMET property prediction, structure-based affinity scoring, and Bayesian optimization. The resulting workflow is a computational twin of the analytical and prioritization stages of the design-make-test-analyze cycle, providing provenance of each numerical output. Across single, and multi-objective optimization studies, SABLE enriches candidate sets for user-defined computational objectives while evaluating only a subset of the enumerated search space. Its modular architecture allows tools and characterization backends to be replaced by editing a simple config file, without modifying operational logic. SABLE provides an extensible decision-support framework for prioritizing synthetically constrained analogs in early-stage drug discovery.

The Organic 6G vision of a network of networks spanning an edge-cloud continuum complemented by non-terrestrial resources requires, to realize its promise, service provisioning that is simple to operate, scalable across independently administered domains, and agile under domain churn (i.e., domains dynamically joining and leaving). Despite advances in cross-domain orchestration, many proposals rely on heavy integration fabrics, multi-layer coordinators, and deep telemetry pipelines that hinder deployability and amplify coordination overhead. We propose a lightweight, decentralized conversational orchestration framework based on Large Language Model (LLM)-driven domain agents. Each domain remains autonomous: an agent observes local state via tools, reasons in a closed loop, and exchanges summaries with neighboring agents over an Agent-to-Agent (A2A) overlay aligned with data-plane coupling. Fast feasible placement is enabled by periodic, routing-like dissemination of reachability advertisements (latency, bottleneck bandwidth, and compute capacity), while safe re-optimization, scaling, and migration are handled through event-driven requests and negotiation. To meet real-time constraints, we deploy a compact reasoning model trained with verifier-based self-verification and periodically refined online via shadow updates. Simulations show manageable, near-linear control-plane overhead as domains scale and during domain joins, and robust decision quality, including recovery after objective changes. We close by outlining future research directions for principled, secure, and uncertainty-aware agentic orchestration in Organic 6G.

Although existing instruction data selection methods have introduced various metrics, the inherent complexity of real-world datasets makes it impractical for any single metric to generalize across all scenarios. Developers are thus often forced to manually inspect data and craft heuristic rules for each new application---a tedious and error-prone process. In this paper, we propose a paradigm shift from manual configuration to automated orchestration via the Instruction Data Selection Agent (DataMaster), which interprets user intent and autonomously composes optimal selection strategies. By allowing users to specify data needs through natural language descriptions, DataMaster simplifies data curation and removes the burden of manual strategy design. Extensive experiments across the math, medical, and code domains show that DataMaster outperforms static baselines in most settings and surpasses full-pool training in a substantial number of cases. The implementation of DataMaster and the scripts needed to reproduce the reported pipeline are publicly available at https://github.com/nju-websoft/DataMaster.

Incident response planning is critical for restoring compromised software systems after cyberattacks. Common practice relies on expert-driven playbooks that encode fixed response procedures, but these static workflows struggle to adapt to evolving incident states, changing recovery objectives, and execution feedback. Recent LLM-based planners and tool-using agents improve automation, yet they remain unstable in long-horizon response because they lack a unified basis for maintaining incident state, aligning actions with the current recovery stage, and reusing historical experience. We present STAIR, an end-to-end agentic planning framework for incident response. The framework maintains the current incident as Graph-as-State, uses a Stage Router to dispatch planning to stage-specialized agents, and retrieves historical experiences to guide action selection. An Execution Harness executes actions, returns feedback to update the incident state, and validates action effects for future experience reuse. Across 100 Docker-based cyber ranges, our framework achieves a normalized defense score of 0.94 and improves over the strongest baseline by 9.5%.

Enterprise data warehouses (DWs) support business-critical analytics, but warehouse task delivery remains a complicated production process involving context retrieval, workflow configuration, code generation, platform submission, and failure diagnosis. Although large language models (LLMs) and coding agents have improved software development, they are insufficient for production DW delivery, which requires dependency-aware orchestration, lifecycle-aware artifact control, and continuous adaptation to evolving platform practices. We present SiriusDeliver, an end-to-end delivery automation agent for production warehouse task submission. SiriusDeliver integrates three components: a hierarchical delivery agent that orchestrates warehouse skills, an artifact lifecycle control module that verifies and revises artifacts before and after platform execution, and a trace-driven skill evolution mechanism that maintains reusable skills from delivery trajectories. We evaluate SiriusDeliver through offline datasets and large-scale production deployment on Tencent Cloud WeData. Offline experiments on real-world warehouse delivery cases show that SiriusDeliver improves delivery success and automation efficiency over representative baselines. During a two-month deployment across 6 business teams and 4 warehouse task types, SiriusDeliver served 3,600 monthly active users and supported 18,240 delivery sessions, achieving an 87.2% end-to-end success rate and a 73.5% autonomous submission rate. A one-month A/B test shows that SiriusDeliver reduces median delivery time from 228 to 23 minutes and engineer effort from 95 to 11 minutes, while maintaining comparable final delivery success.

Long-running molecular simulation campaigns require repeated continuation from saved states, provenance-aware progression, adaptive assessment, and occasional interpretation of workflow conditions that cannot be resolved safely by fixed rules. Here, we present Agent-MD, a framework that places large language model (LLM) reasoning selectively at campaign construction and event-triggered review, while routine simulation, analysis, continuation, archiving, and state progression are handled by a persistent rule-based campaign agent using approved policies and explicit state records. Agent-MD was demonstrated in a grand canonical Monte Carlo-molecular dynamics (GCMC-MD) water-vapor desorption campaign comprising five montmorillonite systems and three sequential relative-humidity states (RH = 0.9-0.3-0.1). Across 15 system-RH states, the workflow completed 120 segmented simulation cycles with state-specific sampling lengths and provenance-aware restart inheritance. Routine production required no live reasoning-agent invocation, while one state reached a review boundary; two preserved incidents were subsequently evaluated through blinded reasoning-agent replay, which identified the underlying workflow problems and recommended appropriate follow-up actions. The simulations also revealed distinct composition-dependent low-RH responses, with Ca-bearing montmorillonite retaining more interlayer water and maintaining a larger basal spacing than the Na- and K-bearing systems, while the highest-charge Na system retained more residual water under dry conditions. These results demonstrate that long-running scientific workflows need not place every operation inside an LLM reasoning loop: selective reasoning can instead be combined with deterministic execution, structured evidence, and validated control handoffs to provide reproducible and auditable agent-assisted molecular simulation.

Hospitals are racing to embed AI, while coping with the surge in adaptation of the technology in other industries, into the triage management, documentation, scheduling, and revenue-cycle workflows, yet most deployments remain as fragmented pilots that stall at the edge of production, exposing patients and institutions to operational fragility, ungoverned risk, and mounting technical debt. At the same time, the global AI-in-healthcare market is projected to exceed nearly USD 1 trillion by 2034, according to the report of Fortune Business Insights, amplifying the financial consequences of architectural missteps and failed scaling strategies. This research proposes a compliance-first Agentic AI pattern catalogue and orchestration framework, purposely built for HIMS, moving beyond the single LLM chatbots and towards a governed ecosystem of autonomous and semi-autonomous agents. The framework extends by adding (i) a taxonomy of Agentic roles, (ii) a formal risk-stratification model that maps each pattern to risk tiers, human-in-the-loop checkpoints, and governance hooks, and (iii) a unified orchestration runtime capable of coordinating multi-agent workflows across EHR/HIMS landscapes such as Epic, Cerner, and MEDITECH. Technically the framework combines vLLM-based inference, optimized paging memory, confidential computing, and MCP based on-premise deployment, enforcing end-to-end encryption and policy-as-code controls aligned with HIPAA, GDPR, the EU AI Act, India's DPDP and DISHA Acts, ISO 27001, ISO 27002, ISO 14971 and IEC 62304. We exhibit how the proposed architecture is capable and efficient to reduce the documentation time, integration effort, and AI pilot attrition while constricting the governance and auditability, offering hospital leaders and governing authorities an urgently needed blueprint to convert AI investment into sustainable clinical, operational, and financial ROI

General-purpose large language model agents have achieved strong performance on tool-augmented tasks, yet they rely on assumptions break down in blockchain environments. On-chain execution is stateful, adversarial, and economically irreversible, exposing three fundamental gaps: Reactivity, Irreversibility, and Observability. We propose ChainClaw, a blockchain-native agent framework built on OpenClaw, that addresses all three gaps through a layered architecture comprising an event-driven orchestration layer, a simulation-based safety intelligence layer, and an on-chain monitoring runtime layer, unified by a cross-layer memory subsystem. ChainClaw closes the Reactivity gap via event ingestion and simulation feedback, the Irreversibility gap via a pre-execution safety pipeline with transaction simulation and action guard, and the Observability gap via an on-chain read adapter and transaction monitor. We evaluate ChainClaw on a purpose-built benchmark covering seven tasks across four categories and five dimensions. ChainClaw consistently outperforms representative baselines on both safety and task completion.

Clinical machine learning (ML) has the potential to support high-stakes medical decision-making, but reliable deployment is often constrained by scarce, heterogeneous, and temporal complexity. Developing effective ML pipelines for such data remains time-consuming and error-prone, while existing automated machine learning (AutoML) systems only partially address this challenge because they largely rely on brute-force search over predefined spaces and lack explicit reasoning and memory. We therefore reformulate AutoML for small clinical data from exhaustive search to reasoning-driven refinement. We propose DoctorAgents, an agentic AI framework that autonomously constructs and optimizes end-to-end ML pipelines through specialized large language model (LLM) agents for generation, validation, and refinement. DoctorAgents backpropagates natural-language feedback through textual gradient descent to perform targeted updates without exhaustive search. Experiments across diverse clinical tasks show that DoctorAgents consistently outperforms established AutoML baselines while producing more interpretable task-specific representations.